27 results on '"Hitoshi Naruse"'
Search Results
2. On force control in human physical skill.
- Author
-
Yuichi Tsumaki, Hitoshi Naruse, Dragomir N. Nenchev, and Masaru Uchiyama
- Published
- 1997
- Full Text
- View/download PDF
3. Virtual reality based teleoperation which tolerates geometrical modeling errors.
- Author
-
Yuichi Tsumaki, Yuichiro Hoshi, Hitoshi Naruse, and Masaru Uchiyama
- Published
- 1996
- Full Text
- View/download PDF
4. Introduction of team-based learning improves understanding of glucose metabolism in biochemistry among undergraduate students
- Author
-
Hironobu Eguchi, Daisaku Yoshihara, Haruhiko Sakiyama, Noriko Fujiwara, Keiichiro Suzuki, and Hitoshi Naruse
- Subjects
Male ,Students, Medical ,education ,Biochemistry ,Peer Group ,Learning effect ,03 medical and health sciences ,Surveys and Questionnaires ,Humans ,Molecular Biology ,Schools, Medical ,030304 developmental biology ,Peer evaluation ,0303 health sciences ,05 social sciences ,050301 education ,Problem-Based Learning ,Knowledge retention ,Test (assessment) ,Group Processes ,Team-based learning ,Glucose ,Active learning ,Test performance ,Female ,Curriculum ,Educational Measurement ,Psychology ,0503 education ,Education, Medical, Undergraduate - Abstract
Team-based learning (TBL) is an active learning method used in many educational institutions. However, there are few examples of its use in basic medicine, such as biochemistry in medical schools. This study used TBL to teach glucose metabolism to first-year medical students. The process was in four phases: preclass preparation, readiness assurance tests, advanced questions, and a TBL test, with peer evaluation and a questionnaire. There were positive correlations between the TBL test, peer evaluation, and individual readiness test performance. Tests were taken immediately after learning and 2 weeks later, and scores decreased significantly less with TBL than traditional lectures (-2.3% vs. -17.5%). This suggests that TBL was more effective than traditional lectures in supporting knowledge retention. We used a Moodle system to facilitate communication between students and teachers, and this was evaluated positively by both groups. It was particularly useful for managing TBL. These findings suggest that TBL could be used to improve student performance in biochemistry.
- Published
- 2020
5. Basic skills examination in a biochemical practical training program for undergraduate students
- Author
-
Keiichiro Suzuki, Hitoshi Naruse, Haruhiko Sakiyama, Noriko Fujiwara, Daisaku Yoshihara, Hironobu Eguchi, and Tomomi Ookawara
- Subjects
Male ,0303 health sciences ,Medical education ,Students, Medical ,media_common.quotation_subject ,education ,05 social sciences ,050301 education ,Biochemistry ,Test (assessment) ,Basic skills ,03 medical and health sciences ,Humans ,Learning ,Female ,Function (engineering) ,Training program ,Psychology ,0503 education ,Molecular Biology ,Curriculum ,Simulation Training ,030304 developmental biology ,media_common ,Education, Medical, Undergraduate - Abstract
University lectures are mainly passive in nature, and there are few subjects in which students need to learn and function independently. Tutorial education and related activities at universities that specialize in medical and pharmaceutical training have been actively carried out, and lectures in conjunction with practical skills are gradually being developed, although progress has been slow in this area. In past years, our biochemistry practice classes have been evaluated in reports dealing with experiments and written examinations, as is done in other universities. However, using this methodology, we are not able to evaluate the extent to which students master biochemical experimental skills. To address this, we introduced a basic skill test to our biochemical curriculum for the first time. Our exams contributed to a deeper understanding of student skills and could be good tools for evaluating the degree of understanding of the students. The students understood the contents of the training well and felt interested in research in the field of basic medicine. Thus, we conclude that introducing practical testing to biochemical practice was effective for medical students in the field of biochemistry. © 2019 International Union of Biochemistry and Molecular Biology, 47(3):279-287, 2019.
- Published
- 2018
6. Depiction of residual emboli following pulmonary embolism with thrombotic scintigraphy
- Author
-
Kenji Hiromoto, Keiko Takahashi, Mamoru Ohnishi, Hitoshi Naruse, Mitsumasa Ohyanagi, and Atsunori Ueda
- Subjects
Adult ,Blood Platelets ,Male ,medicine.medical_specialty ,Venography ,Scintigraphy ,Sensitivity and Specificity ,Recurrence ,Internal medicine ,Organometallic Compounds ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Treatment Failure ,cardiovascular diseases ,Stage (cooking) ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Warfarin ,Reproducibility of Results ,General Medicine ,Heparin ,Middle Aged ,Pelvic cavity ,Oxyquinoline ,Prognosis ,medicine.disease ,Pulmonary embolism ,Treatment Outcome ,medicine.anatomical_structure ,Positron-Emission Tomography ,Circulatory system ,Cardiology ,Female ,Radiology ,Radiopharmaceuticals ,Pulmonary Embolism ,business ,medicine.drug - Abstract
In the treatment of pulmonary embolism (PE), the presence of residual emboli is known to seriously affect the recurrence and prognosis. We attempted to depict the residual emboli in the subacute stage of PE using indium-111-oxine labeled platelet scintigraphy (In-plt). In-plt was performed on 22 patients with PE who showed an improvement according to lung perfusion scintigraphy. Their accumulation was assessed along with the blood coagulation ability measured on the same day. In addition, radioisotope venography (RI-veno) was performed simultaneously with In-plt to measure the circulatory findings in the lower limb for comparison. All patients received systemic heparin during the acute stage and received warfarin at the time of testing. Accumulation of In-plt was observed in 7 patients (32%), and positive signals were found in the lower limbs or pelvic cavity in all cases. Two patients were suspected of having poor lower limb circulation from their Rl-veno findings, and these findings were largely consistent with the areas of In-plt accumulation. Some emboli persist after extensive anti-coagulation therapy. The use of In-plt is effective in determining the therapeutic measures and assessing the prognosis as this method allows us to clearly depict the existence of such emboli.
- Published
- 2005
- Full Text
- View/download PDF
7. Development of a Compact 6-DOF Haptic Interface
- Author
-
Yuichi Tsumaki, Masaru Uchiyama, Koyu Abe, Masahiro Kinami, Hiroshi Inou, and Hitoshi Naruse
- Subjects
Computer Science::Robotics ,Mechanism (engineering) ,Compact space ,Computer science ,Control theory ,Teleoperation ,Serial port ,Torque sensor ,Workspace ,Sensitivity (control systems) ,ComputingMethodologies_COMPUTERGRAPHICS ,Haptic technology - Abstract
In this paper we propose a new compact 6-DOF haptic interface. It contains a five-bar spatial parallel mechanism for orientation, placed on a modified Delta parallel-link mechanism. This serial connection of the two parallel mechanisms yields a wide workspace. In addition, the structure also ensures fast motion, high-power motion and compactness. Furthermore, the mechanisms are free of singularities, which also contributes to the wide workspace. The haptic interface includes a small 6-axis force/torque sensor and high-reduction geared motors to realize good sensitivity and compactness. In addition, the stiffness of the modified Delta mechanism is also discussed.
- Published
- 2005
- Full Text
- View/download PDF
8. Cilnidipine as an agent to lower blood pressure without sympathetic nervous activation as demonstrated by iodine-123 metaiodobenzylguanidine imaging in rat hearts
- Author
-
Tadaaki Iwasaki, Mitsumasa Ohyanagi, Miho Masai, Takatoshi Sakaki, Keiko Takahashi, Hitoshi Naruse, and Minoru Fukuchi
- Subjects
Male ,Dihydropyridines ,Sympathetic Nervous System ,Nifedipine ,Femoral vein ,Blood Pressure ,Heart Conduction System ,Heart Rate ,Heart rate ,medicine ,Animals ,Plethysmograph ,Radiology, Nuclear Medicine and imaging ,Rats, Wistar ,Radionuclide Imaging ,Antihypertensive Agents ,Voltage-dependent calcium channel ,business.industry ,Heart ,General Medicine ,Cilnidipine ,Calcium Channel Blockers ,Rats ,3-Iodobenzylguanidine ,Blood pressure ,medicine.anatomical_structure ,Anesthesia ,Radiopharmaceuticals ,business ,medicine.drug ,Artery - Abstract
Administration of short-acting antihypertensive agents to patients with ischemic heart disease results in increased sympathetic nervous activity and is associated with worsened outcomes. Cilnidipine is an agent which blocks not only L-type calcium channels at the smooth muscle in the artery, but also N-type calcium channels at the presynaptic terminal. The goal of the present study was to determine the effect of cilnidipine on sympathetic nervous activity as on agent which blocks both L-type and N-type calcium channels at the presynaptic terminal, on sympathetic nervous activity in an experimental rat model using iodine-123 metaiodobenzylguanidine (MIBG) myocardial imaging.Fourteen-week-old Wistar-Kyoto rats were divided into 3 separate groups: CTR group (control: distilled water administered), Nif group (nifedipine administered), or Cil group (cilnidipine administered). Agents were administered via a stomach tube, followed by injection of MIBG via the femoral vein. Systolic blood pressure (SBP) and heart rate (HR) were measured by tail-cuff plethysmography just prior to administration of antihypertensive drugs and 150 minutes later. Initial imaging (Ce) and delayed imaging (Cd) were defined as the sum of density counts in the region of interest created by adjusting to myocardial edge, and were corrected for both physical decay and weight. The myocardial washout rate (WR) was defined as the percent change in the count density from the initial to delayed images.Significant decreases in SBP were seen in the Nif group (from 132 +/- 3 mmHg to 85 +/- 5 mmHg, p0.0001) and the Cil group (from 128 +/- 4 mmHg to 92 +/- 7 mmHg, p = 0.0008), whereas no significant change in SBP was noted in the CTR group (from 123 +/- 5 mmHg to 127 +/- 3 mmHg). HR significantly increased in the Nif group (from 290 +/- 12/min to 378 +/- 14/min, p0.0001) but not in the CTR (from 278 +/- 3/min to 300 +/- 6/min) or Cil (from 291 +/- 6/min to 303 +/- 5/min) groups. WR was significantly greater in the Nif group (64.7 +/- 0.5%) when compared to the CTR (56.4 +/- 1.2%, p = 0.0031) or the Cil (55.4 +/- 2.2%, p = 0.0016) groups.In contrast to nifedipine, administration of cilnidipine did not result in increased myocardial sympathetic nervous activation.
- Published
- 2003
- Full Text
- View/download PDF
9. Discordant iodine-123 metaiodobenzylguanidine uptake area reflects recovery time dispersion in acute myocardial infarction
- Author
-
Tohru Arii, Keiko Takahashi, Miho Masai, Hitoshi Naruse, Mitsumasa Ohyanagi, Masato Morita, Tadaaki Iwasaki, and Minoru Fukuchi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Myocardial Infarction ,Mibg uptake ,Positive correlation ,Iodine Radioisotopes ,Internal medicine ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Statistical dispersion ,cardiovascular diseases ,Myocardial infarction ,Aged ,Tomography, Emission-Computed, Single-Photon ,business.industry ,Arrhythmias, Cardiac ,General Medicine ,Iodine 123 metaiodobenzylguanidine ,Middle Aged ,medicine.disease ,3-Iodobenzylguanidine ,Thallium Radioisotopes ,Neural function ,Electrocardiography, Ambulatory ,Myocardial cell ,Cardiology ,Female ,Radiopharmaceuticals ,business ,Nuclear medicine ,Holter monitoring - Abstract
lodine-123 metaiodobenzylguanidine (MIBG) uptake was reported to be reduced compared to Tl-201 (Tl) in acute myocardial infarction (AMI). Within such an area, degrees of both sympathetic neural function and ischemic myocardial cell damage are considered to be greatly dispersed. These kinds of damage were reported to effect reporalization time in myocardial cells, and we evaluated our hypothesis that extension of the discordant MIBG uptake area correlates with recovery time (RT) dispersion and relate ventricular arrhythmias in AMI. MIBG and Tl images were obtained in AMI patients. Regional Tl or MIBG uptake was estimated in 9 segments of SPECT by using four-point scoring. The total score was the sum of scores in 9 SPECT segments. ATI-MIBG was calculated by subtracting the total MIBG score from the total Tl score. Corrected RT (RTc) was measured as a signal-averaged ECG. RTc dispersion was defined as the difference between maximal and minimal RTc. The patients were assigned to two groups (group A;or = Lown 4a, group B;or = Lown 4b) according to the results of 24-hour Holter monitoring. A positive correlation between RTc dispersion and ATI-MIBG was found. ATI-MIBG and RTc dispersion in group B were greater than those in group A. These results suggested that ATI-MIBG could be used to predict the development of malignant ventricular arrhythmias.
- Published
- 2001
- Full Text
- View/download PDF
10. Relation between myocardial response to dobutamine stress and sympathetic nerve activation in patients with idiopathic dilated cardiomyopathy: A comparison of123I-MIBG scintigraphic and echocardiographic data
- Author
-
Tohru Arii, Tadaaki Iwasaki, Minoru Fukuchi, Mitsumasa Ohyanagi, Miho Masai, Makoto Ohnishi, Keiko Takahashi, Hitoshi Naruse, Tomohiro Kondo, and Takatoshi Sakaki
- Subjects
Adult ,Cardiomyopathy, Dilated ,Male ,medicine.medical_specialty ,Cardiomyopathy ,Diastole ,Scintigraphy ,Norepinephrine (medication) ,Heart Conduction System ,Dobutamine ,Internal medicine ,Idiopathic dilated cardiomyopathy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Radionuclide Imaging ,Aged ,medicine.diagnostic_test ,business.industry ,General Medicine ,Dobutamine stress ,Adrenergic beta-Agonists ,Middle Aged ,medicine.disease ,3-Iodobenzylguanidine ,Echocardiography ,Heart failure ,Cardiology ,Regression Analysis ,Female ,Radiopharmaceuticals ,business ,medicine.drug - Abstract
It is likely that a close association exists between findings obtained by two methods: dobutamine stress echocardiography and 123I-MIBG scintigraphy. Both of these methods are associated with beta-adrenergic receptor mechanisms. This study was conducted to demonstrate the relation between myocardial response to dobutamine stress and sympathetic nerve release of norepinephrine in the failing heart. In 12 patients with heart failure due to idiopathic dilated cardiomyopathy, the myocardial effects of dobutamine stress were evaluated by low-dose dobutamine stress echocardiography: and sympathetic nerve function was evaluated by scintigraphic imaging with iodine-123 [123I] meta-iodobenzylguanidine (MIBG), an analogue of norepinephrine. Echocardiography provided quantitative assessment of wall motion and left ventricular dilation; radiotracer studies with 123I-MIBG provided quantitative assessment of the heart-to-mediastinum (H/M) uptake ratio and washout rate. Results showed that H/M correlated with baseline wall motion (r = 0.682, p = 0.0146), wall motion after dobutamine stress (r = 0.758, p = 0.0043), the change in wall motion (r = 0.667, p = 0.0178), and with left ventricular diastolic diameter (r = 0.837, p = 0.0007). In addition, the 123I-MIBG washout rate correlated with baseline wall motion (r = 0.608, p = 0.0360), wall motion after dobutamine stress (r = 0.703, p = 0.0107), and with the change in wall motion (r = 0.664, p = 0.0185). Wall motion, especially in the myocardial response to dobutamine stress, is related to sympathetic nerve activity in heart failure.
- Published
- 2000
- Full Text
- View/download PDF
11. Bis(enediyne) Macrocycles: Synthesis, Reactivity, and Structural Analysis
- Author
-
Stephen C. Brand, Hitoshi Naruse, Michael M. Haley, Heather S. Blanchette, and Timothy J. R. Weakley
- Subjects
chemistry.chemical_compound ,Diacetylene ,Polymerization ,Chemistry ,Stereochemistry ,Organic Chemistry ,Drug Discovery ,Enediyne ,Molecule ,Reactivity (chemistry) ,Annulene ,Biochemistry ,Combinatorial chemistry - Abstract
We describe below the syntheses of five macrocycles possessing two enediyne warheads, along with the structural and thermal analyses of these bis(enediyne) compounds. The solid-state packing of compound 6 suggests the possibility for the molecule to undergo a topochemical diacetylene polymerization.
- Published
- 2000
- Full Text
- View/download PDF
12. Model-Based Space Teleoperation System with Robustness against Geometrical Modeling Errors
- Author
-
Yuichiro Hoshi, Yuichi Tsumaki, Hitoshi Naruse, and Masaru Uchiyama
- Subjects
Computer science ,Control theory ,Robustness (computer science) ,Teleoperation ,Control engineering ,Virtual reality - Published
- 1997
- Full Text
- View/download PDF
13. Preoperative evaluation of myocardial viability by thallium-201 imaging in patients with old myocardial infarction who underwent coronary revascularization
- Author
-
Minoru Fukuchi, Takashi Miyamoto, Tadaaki Iwasaki, Mitsumasa Ohyanagi, and Hitoshi Naruse
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Infarction ,chemistry.chemical_element ,Revascularization ,Scintigraphy ,Preoperative Care ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,cardiovascular diseases ,Myocardial infarction ,Wall motion ,Angioplasty, Balloon, Coronary ,Coronary Artery Bypass ,Radionuclide Imaging ,Aged ,medicine.diagnostic_test ,business.industry ,Myocardium ,Heart ,General Medicine ,Middle Aged ,medicine.disease ,Coronary revascularization ,body regions ,Thallium Radioisotopes ,chemistry ,Echocardiography ,Clinical diagnosis ,cardiovascular system ,Thallium ,Female ,Radiology ,business - Abstract
The myocardial uptake and redistribution in thallium scintigraphy and the regional wall motion by echocardiography were evaluated by a semi-quantitative method in 42 patients who previously had myocardial infarction (50 target vessels) and underwent coronary revascularization. The aim of this study was to elucidate the significance of the initial image, delayed image and redistribution on thallium-201 scintigraphy for clinical diagnosis of the myocardial viability. As a semi-quantitative analysis, we used a bull's-eye display for thallium image and centerline method for echocardiographic wall motion, and compared the results before and after revascularization. As a result, the thallium grade improved postoperatively in all 17 areas which preoperative had showed redistribution, and also in 11 of the 32 areas without preoperative redistribution. The sensitivity, specificity and accuracy of preoperative thallium redistribution for predicting myocardial viability were 61%, 100% and 78%, respectively, when the postoperative improvement in the thallium grade was used as the standard. The postoperative probability of improvement in the thallium grade increased in proportion to the preoperative thallium grade (delayed image) (p less than 0.01). There was no correlation between the preoperative thallium delayed image and postoperative improvement in wall motion. Postoperative improvement in thallium image and wall motion could not be predicted from the preoperative wall motion. Thus, postoperative improvement in thallium images can be anticipated if redistribution is present on the preoperative thallium image, and the preoperative thallium delayed image is useful for predicting myocardial viability. Improvement in wall motion could not be predicted preoperatively by these methods.
- Published
- 1992
- Full Text
- View/download PDF
14. Indications for Coronary Revascularization and the Postoperative Evaluations Using Thallium-201 Exercise Myocardial Scintigraphy and a Bull’s-Eye Display
- Author
-
Tadaaki Iwasaki, Hitoshi Naruse, Minoru Fukuchi, and Mitsumasa Ohyanagi
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,chemistry.chemical_element ,General Medicine ,Scintigraphy ,Revascularization ,Coronary revascularization ,Coronary artery bypass surgery ,chemistry ,Myocardial scintigraphy ,Positron emission tomography ,Internal medicine ,medicine ,Cardiology ,Thallium ,Radiology ,Bull's Eye ,business - Abstract
Thallium-201 exercise myocardial scintigraphy and quantitative analysis using a bull's-eye display were performed in 40 cardiac patients ― 22 bypass and 18 percutaneous transluminal coronary angioplasty (PTCA) cases ― to determine the indications for coronary artery bypass surgery and PTCA and to evaluate the degree of postoperative improvement. The results were as follows: 1) The preoperative mean WR of the improved areas (33 vessels) was 20±15%, while that of the unimproved areas (17 vessels) was 33±8%. We judged that an area was suitable for revascularization when the preoperative WR was less than 25% which was the lower limit of the normal range. In this way 21 vessels were judged to be suitable for surgery, and a postoperative improvement was obtained in 18 areas. We concluded that a myocardial region was suitable for revascularization when the preoperative WR and percent uptake were below the normal range. Since the scintigraphic evaluation accorded with the improvement in exercise tolerance and with patency on coronary angiography, the method seems useful for the postoperative follow-up
- Published
- 1990
- Full Text
- View/download PDF
15. Mechanisms responsible for delayed and immediate hemolytic transfusion reactions in a patient with anti-E + Jk(b)+ Di(b) and anti-HLA alloantibodies
- Author
-
Nobuo Araki, Makiko Hashimoto, Hitoshi Naruse, Hirokazu Samejima, Hiroaki Nakamura, Yoshihiro Bouike, Ako Mori, Takahiro Okamoto, Akira Takeda, and Mari Wakabayashi
- Subjects
Hypersensitivity, Immediate ,Male ,Blood transfusion ,Time Factors ,medicine.medical_treatment ,Immunology ,Human leukocyte antigen ,Toxicology ,Proinflammatory cytokine ,Antigen ,HLA Antigens ,Isoantibodies ,Immunology and Allergy ,Medicine ,Humans ,In patient ,Hypersensitivity, Delayed ,Kidd Blood-Group System ,Progressive anemia ,Aged ,Autoantibodies ,Pharmacology ,Aged, 80 and over ,Rh-Hr Blood-Group System ,biology ,business.industry ,General Medicine ,Cytokine ,Blood Grouping and Crossmatching ,biology.protein ,Blood Group Antigens ,Cytokines ,Antibody ,business ,Erythrocyte Transfusion - Abstract
Immediate hemolytic transfusion reactions (IHTR) occurred in the course of delayed hemolytic transfusion reactions (DHTR). An 84-year-old man had received a blood transfusion 20 years ago. Progressive anemia developed, because of continuous bleeding from a bladder tumor. He was transfused with concentrated red blood cells (CRC) which were Rh-E antigen negative, because he had anti-E antibodies (day 0). He received CRC on day 3, and underwent resection of bladder tumor on day 6. Although crossmatch-compatible CRCs were prepared for the operation, those were not required and were kept in a refrigerator in the ward. On day 9, when a CRC kept in the ward was transfused, he suddenly had a IHTR. In order to analyze a mechanism of IHTR, the anti-Jk(b) and anti-Di(b) antibodies, anti-HLA antibodies and the concentrations of inflammatory cytokines were measured in serum samples. The anti-Jk(b) and anti-Di(b) antibodies increased prior to IHTR experienced on day 9. The concentrations of IL-6 and IL-1beta increased from day 2, while the concentration of IL-8 increased from day 7. The anti-HLA class I antibody could be detected 2 days before IHTR. Thus, the anti-Jk(b) and anti-Di(b) antibodies induced the production of inflammatory cytokines and symptoms of DHTR and IHTR. The anti-HLA class I antibody could be produced in spite of using the filer for removing leukocytes, and may take part in the induction of IHTR. Further, blood products should be transfused soon after completing a crossmatch test in patients with anti-RBC alloantibodies.
- Published
- 2005
16. The relationship between clinical stage, prognosis and myocardial damage in patients with Duchenne-type muscular dystrophy: five-year follow-up study
- Author
-
Junko Miyagi, Tadaaki Iwasaki, Mitsumasa Ohyanagi, Tohru Arii, Hitoshi Naruse, and Kenji Jinnai
- Subjects
Adult ,Male ,medicine.medical_specialty ,Statistics as Topic ,Sensitivity and Specificity ,Severity of Illness Index ,Ventricular Dysfunction, Left ,Internal medicine ,Severity of illness ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Stage (cooking) ,Muscular dystrophy ,Thallium ,Muscle, Skeletal ,Cardiac imaging ,Heart Failure ,Myocardial Stunning ,Tomography, Emission-Computed, Single-Photon ,Myocardial stunning ,business.industry ,Iodobenzenes ,Incidence (epidemiology) ,Fatty Acids ,Reproducibility of Results ,General Medicine ,medicine.disease ,Prognosis ,Muscular Dystrophy, Duchenne ,medicine.anatomical_structure ,Ventricle ,Heart failure ,Cardiology ,Radiopharmaceuticals ,business ,Follow-Up Studies - Abstract
The evaluation of myocardial damage by [123I] 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) imaging, which represents free fatty acid metabolism, has not been reported in patients with Duchenne-type muscular dystrophy (DMD). To date, the relationship between clinical stage, prognosis and myocardial damage has not been evaluated by radionuclear cardiac imaging. The main goal of this study was to elucidate the relationship of quantitative indices of myocardial damage obtained by radionuclear cardiac imaging ([201T1] and [123I] BMIPP) to clinical stage and incidence of severe cardiac events in patients with Duchenne-type muscular dystrophy (DMD).Methods: The study population consisted of 28 male patients with DMD. The average age at the beginning of observation was 19.1 ± 7.4 yrs. Nuclear tomographic imaging was performed using [201T1] and [123I] BMIPP. The mid-ventricular short axial slices were classified into four anatomical regions, and the normalized count data in these areas (TL, BM) were obtained. The endpoint was the occurrence of heart failure during the follow up period.Results: Thirteen cases of heart failure occurred during the 5-year follow-up period, including three cases with cardiac death due to congestive heart failure. Clinical staging correlated directly with TL (p = 0.0118) and BM (p = 0.0401) in the whole left ventricle. In regional TL analysis, an association was observed only in the septum (p = 0.0151), and in the anterior (p = 0.0361) region. The only discrepancy between the tracer parameters (TL — BM) in the septum was observed with the radionuclear cardiac values, which exhibited a relationship with cardiac events (p = 0.0124). This discordance, TL < BM, was contrary to that usually observed in patients with ischemic heart disease.Conclusion: The septum is the critical area of significance for cardiac events and outcome in patients with DMD. The uptake of [201T1] in this area was representative of the clinical stage, and TL-BM correlated well with the prognosis.
- Published
- 2004
17. Usefulness of indium-111-oxine-labeled leukocyte scintigraphy in diagnosis of inflammation associated with chronic aortic dissection
- Author
-
Takashi Miyamoto, Keiko Takahashi, Hitoshi Naruse, Miho Masai, Mitsumasa Ohyanagi, Tadaaki Iwasaki, and Minoru Fukuchi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Inflammation ,Aorta, Thoracic ,Necrotic Change ,Leukocyte scintigraphy ,Leukocyte Count ,medicine.artery ,medicine ,Leukocytes ,Organometallic Compounds ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Radionuclide Imaging ,Vasculitis, Central Nervous System ,Aged ,Aortic dissection ,Aorta ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Oxyquinoline ,Aortic wall ,Aortic Dissection ,medicine.anatomical_structure ,Chronic Disease ,cardiovascular system ,Disease Progression ,Female ,Radiology ,medicine.symptom ,business ,Tomography, X-Ray Computed ,Blood vessel ,Aortic Aneurysm, Abdominal ,Follow-Up Studies - Abstract
Background: Patients with chronic aortic dissection require monitoring for indications of disease progression. In present study, inflammation adjacent to associated aortic wall was evaluated by indium-111-oxine-labeled leukocyte scintigraphy, scince inflammation of the blood vessel wall often associates with progression of chronic aortic dissection.Methods and Results: Fifteen patients with aortic dissection underwent indium-111-oxine-labeled leukocyte scintigraphy. Seven showed positive images at sites corresponding to the actual sites of the dissociated aorta. Four patients with positive images underwent surgery. Histologic examination revealed inflammatory and necrotic changes of the aortic wall. During a mean follow-up period of 2.3 years, progression of aortic dissection was observed in two of the seven patients with positive intimal imaging.Conclusion: Indium-111-oxine-labeled leukocyte scintigraphy may be a useful noninvasive technique to assess the persistent inflammation in patients with chronic aortic dissection.
- Published
- 2002
18. Detection of inflammation in aortic aneurysms with indium 111-oxine--labeled leukocyte imaging
- Author
-
Kiyomitsu Ikeoka, Takashi Miyamoto, Miho Masai, Minoru Fukuchi, Mitsumasa Ohyanagi, Tadaaki Iwasaki, Keiko Takahashi, and Hitoshi Naruse
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Inflammation ,Scintigraphy ,Lesion ,Text mining ,Aneurysm ,medicine ,Leukocytes ,Organometallic Compounds ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Radionuclide Imaging ,Aorta ,Aged ,medicine.diagnostic_test ,business.industry ,Indium Radioisotopes ,Middle Aged ,medicine.disease ,Oxyquinoline ,Aortic Aneurysm ,cardiovascular system ,Female ,Radiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Tomography, X-Ray Computed - Abstract
The exact cause of aortic aneurysms is not completely understood. Histologically, the atherosclerotic lesions present in an aneurysm contain numerous inflammatory cells. This finding represents active atherosclerosis, which can cause lesion expansion. In this study we investigated the role of scintigraphy in the evaluation of inflammation in aortic aneurysms.We performed imaging using indium 111-oxine--labeled leukocytes in 14 patients with aortic aneurysms (10 thoracic and 4 abdominal) diagnosed by computed tomography. Peripheral blood evidence of inflammation was assessed on the same day. In 8 patients who subsequently underwent graft replacement of the aneurysm, the excised specimen was examined for evidence of inflammatory infiltration and correlated with the scintigraphic findings. Scintigraphic accumulation of labeled leukocytes was present in 10 of the 14 patients. Although all patients had a small increase in the erythrocyte sedimentation rate, there was no significant difference in the erythrocyte sedimentation rate between patients with positive and negative scintigram results. In 5 of the 8 surgical patients with positive scintigram results, the resected specimens demonstrated numerous inflammatory cells in the adventitia of the aortic wall and atherosclerotic changes in the media. There was no correlation between the presence of periaortic inflammatory adhesions at the time of surgery and the scintigraphic results.The accumulation of In-111-oxine--labeled leukocytes is a potentially useful scintigraphic marker of inflammatory infiltration in aortic aneurysms.
- Published
- 2001
19. ChemInform Abstract: Bis(enediyne) Macrocycles: Synthesis, Reactivity, and Structural Analysis
- Author
-
Stephen C. Brand, Heather S. Blanchette, Timothy J. R. Weakley, Hitoshi Naruse, and Michael M. Haley
- Subjects
chemistry.chemical_compound ,Polymerization ,Diacetylene ,Chemistry ,Polymer chemistry ,Enediyne ,Molecule ,Reactivity (chemistry) ,General Medicine - Abstract
We describe below the syntheses of five macrocycles possessing two enediyne warheads, along with the structural and thermal analyses of these bis(enediyne) compounds. The solid-state packing of compound 6 suggests the possibility for the molecule to undergo a topochemical diacetylene polymerization.
- Published
- 2001
- Full Text
- View/download PDF
20. Prediction of functional recovery and prognosis in patients with acute myocardial infarction by 123I-BMIPP and 201Tl myocardial single photon emission computed tomography: a multicenter trial
- Author
-
Kouichi Kitahara, Kamon Imai, Takanori Osada, Shigeyuki Nishimura, Toshiya Muramatsu, Hiroshi Yoshida, Nobukazu Takahashi, Tatsuo Ito, Tsunehiko Nishimura, Teishi Kajiya, Kouji Terada, Hiroki Sugihara, Hitoshi Naruse, and Masashi Iwabuchi
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Myocardial Infarction ,Myocardial Ischemia ,Coronary Disease ,Single-photon emission computed tomography ,Disease-Free Survival ,Ventricular Function, Left ,Iodine Radioisotopes ,Predictive Value of Tests ,Recurrence ,Risk Factors ,Multicenter trial ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Myocardial infarction ,Aged ,Tomography, Emission-Computed, Single-Photon ,Ejection fraction ,Ventricular function ,medicine.diagnostic_test ,business.industry ,Iodobenzenes ,Fatty Acids ,Reproducibility of Results ,Heart ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Survival Rate ,Thallium Radioisotopes ,medicine.anatomical_structure ,Death, Sudden, Cardiac ,Heart failure ,Cardiology ,Regression Analysis ,Female ,Radiopharmaceuticals ,business ,Artery ,Follow-Up Studies - Abstract
123I-BMIPP [15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid] was developed for metabolic imaging with SPECT. A multicenter collaborative study was conducted on a large patient series to determine whether 123I-BMIPP and 201Tl myocardial SPECT are of use in predicting the prognosis and ventricular function after acute myocardial infarction (AMI). Patients with uncomplicated first AMI underwent resting 123I-BMIPP and 201Tl myocardial SPECT in the subacute phase after the onset of AMI. Of these, 167 patients who had been followed up for an average of 22 months were retrospectively reviewed to predict serious cardiac events and recurrent ischemia. In addition, the association between changes in radionuclide parameters and recurrent ischemia was investigated in Subgroup A (58 patients) who had repeated SPECT in the chronic phase. Furthermore, prediction of the ejection fraction (EF) was investigated in Subgroup B (94 patients) and Subgroup C (76 patients) in whom left ventriculography was performed at the time of discharge and 90 days or more after the onset, respectively. The prognosis was generally favorable, with 4 cases of cardiac death (2%), 3 of heart failure (2%), 4 of nonfatal reMI (2%), and 25 of recurrent ischemia (15%). The results of Cox multivariate regression analysis revealed a high probability of serious cardiac events in patients who were elderly (p = 0.04), who had 90% or more residual stenosis of the infarct-related artery (p = 0.09), and who had a high BMIPP defect score (p = 0.17). There was a high probability of recurrent ischemia in elderly patients (p = 0.10) who had multi-vessel disease (p = 0.03), but no association was found with radionuclide parameters in the subacute phase. In Subgroup A, however, the probability of recurrent ischemia tended to be high in patients with a large mismatch scorebetween 123I-BMIPP and 201Tl in the subacute to chronic phase. An important observation was that the extent of BMIPP defect was more strongly correlated with EF at the time of discharge and 90 days or more after the onset than the extent of Tl defect (r = -0.60 vs. r = -0.47, and r = -0.53 vs. r = -0.43, respectively). In addition, multiple regression analysis showed that parameters related to the BMIPP defect were also better predictive factors of EF both at the time of discharge and 90 days or more after the onset. In conclusion, resting 123I-BMIPP and 201Tl myocardial SPECT performed in the subacute phase of AMI were shown to be useful in predicting prognosis and ventricular function for patient management.
- Published
- 1998
21. Clinical usefulness of iodine 123-labeled fatty acid imaging in patients with acute myocardial infarction
- Author
-
Tadaaki Iwasaki, Tohru Arii, Hitoshi Naruse, Tomohiro Kondo, Minoru Fukuchi, Mitsumasa Ohyanagi, and Masato Morita
- Subjects
Male ,medicine.medical_specialty ,Subacute phase ,Myocardial Infarction ,Single-photon emission computed tomography ,Iodine Radioisotopes ,Internal medicine ,Iodine-123 ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Myocardial infarction ,Angioplasty, Balloon, Coronary ,chemistry.chemical_classification ,Myocardial Stunning ,Tomography, Emission-Computed, Single-Photon ,Myocardial stunning ,medicine.diagnostic_test ,business.industry ,Iodobenzenes ,Fatty Acids ,Fatty acid ,Heart ,Middle Aged ,medicine.disease ,Coronary revascularization ,Thallium Radioisotopes ,chemistry ,Subtraction Technique ,Cardiology ,Female ,Stents ,Cardiology and Cardiovascular Medicine ,business - Abstract
Iodine 123-labeled 15-(p-iodophenyl)-3R,S-methylpentadecanoic acid (BMIPP) has recently been developed, since normal myocardium metabolizes free fatty acids. This study investigated the clinical usefulness of BMIPP imaging in patients with acute myocardial infarction (MI), particularly in the detection of stunned myocardium in patients who underwent acute coronary revascularization. The subjects were 41 patients with acute MI who had undergone emergency coronary revascularization. Both BMIPP and thallium-201 images at rest were obtained during the subacute phase. The myocardial distribution of radiotracers was quantified by generating circumferential count-distribution profile analysis. Initial 201 Tl imaging, delayed 201Tl imaging, and BMIPP imaging were performed, and the mean count densities in the infarct region (initial 201Tl images [TL1], delayed 201Tl images [TL2], and BMIPP images in the infarct region [BM], respectively) were obtained. The differences between mean count densities (TL1-BM: BM subtracted from TL1; TL2-BM: BM subtracted from TL2) were also calculated. BM showed a higher correlation with wall motion data by echocardiography (WM) in the acute phase than other nuclear imaging tests, whereas TL2 showed the highest correlation with WM in the chronic phase. Acute to chronic WM improvement showed a good correlation with TL2-BM. Single photon emission computed tomography imaging with BMIPP is a candidate for providing the “memory image” of ischemic damage, whereas TL2 reflects all viable tissue. The mismatch between the tracers can serve as an indicator of myocardial stunning.
- Published
- 1998
22. Comparative accuracy of various Tl-201 reinjection imaging protocols to detect myocardial viability
- Author
-
Tomohiro Kondo, Minoru Fukuchi, Tohru Arii, Hitoshi Naruse, Mitsumasa Ohyanagi, Masato Morita, and Tadaaki Iwasaki
- Subjects
Male ,medicine.medical_specialty ,Percutaneous transluminal coronary angioplasty ,Myocardial Infarction ,Clinical Protocols ,Internal medicine ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Wall motion ,Myocardial infarction ,Coronary Artery Bypass ,Aged ,Tomography, Emission-Computed, Single-Photon ,business.industry ,Heart ,General Medicine ,Middle Aged ,medicine.disease ,Predictive value ,Coronary revascularization ,Thallium Radioisotopes ,Bypass surgery ,Echocardiography ,Cardiology ,Exercise Test ,Female ,business - Abstract
The conventional exercise-3 hours-redistribution thallium-201 [201Tl] imaging protocol has been recognized to be suboptimal for reliable detection of myocardial viability. Although201Tl restreinjection after exercise has improved detection of viable myocardium, it is still underestimated in some patients. The present study was designed to compare detection of viable myocardium in five separate imaging steps: step 1: initial-exercise imaging, step 2: delayed-exercise imaging, step 3: Tl-201 reinjection imaging after delayed-exercise imaging, step 4: separate day rest-reinjection imaging, and step 5: separate day delayed-rest imaging. The study group consisted of 22 patients scheduled for coronary revascularization (either percutaneous transluminal coronary angioplasty or coronary bypass surgery). Pre- and postintervention echocardiographic wall motion and thickness served as independent markers of myocardial viability. Results: Accuracy in identifying myocardial viability gradually improved incrementally from201Tl imaging step 1 to step 5. The positive predictive value, negative predictive value and overall accuracy were best for the separate day delayed-rest study (step 5) at 90%, 33% and 78%, respectively. Myocardial segments had fixed defects on separate day delayed-rest201Tl imaging (step 5), but nevertheless echocardiographic evidence of myocardial viability indicated less severe defects than segments judged non viable by echocardiography (p = 0.021). The overall accuracy of separate day delayed-rest imaging (step 5) in predicting viability improved to 88% when segments with moderate or mild defects were considered viable. In conclusion, the most reliable predictor of myocardial viability with201Tl imaging is defect severity on separate day delayed-rest images.
- Published
- 1996
23. The first report of a case with acute myocardial infarction showing familial deficiency of creatine kinase
- Author
-
Tadaaki Iwasaki, Keiko Takahashi, Seinosuke Kawashima, Toshiaki Matsumoto, Hitoshi Naruse, Jun Tateishi, Kazuhiko Sugisawa, Nagao Yasutomi, Jun Shibuya, and Tatsuo Tozawa
- Subjects
Male ,medicine.medical_specialty ,Myocardial Infarction ,Isozyme ,Electrocardiography ,Internal medicine ,Internal Medicine ,Medicine ,ST segment ,Humans ,Myocardial infarction ,Lactic Acid ,Treadmill ,Creatine Kinase ,Depression (differential diagnoses) ,biology ,business.industry ,Muscles ,Myocardium ,Skeletal muscle ,General Medicine ,Middle Aged ,medicine.disease ,Pedigree ,Isoenzymes ,Endocrinology ,medicine.anatomical_structure ,biology.protein ,Exercise Test ,Lactates ,Creatine kinase ,Abnormality ,business - Abstract
A 46-year-old male patient was diagnosed as suffering from acute myocardial infarction, but his serum creatine kinase (CK) level was extremely low and no CK isozymes were detected in the serum. The total CK activities in the skeletal muscle amounted to only 2% of that of the control, Electrophoresis of the CK isozymes in the skeletal muscle showed that CK-MM was absent but the CK-BB and abnormal isozyme bands were present. There was no evidence of myocardial ischemia, although the exercise treadmill test revealed ST segment depression in the chest leads. One of the patient's sisters had an extremely low serum CK level suggesting inheritance of this abnormality. This is the first report of a case showing familial deficiency of CK.(Internal Medicine 31 : 611-616, 1992)
- Published
- 1992
24. Myocardial uptake of antimyosin antibody compared with serum myosin light chain I levels in patients with myocardial infarction
- Author
-
Mitsuko Suehiro, Hitoshi Naruse, Tadaaki Iwasaki, and Minoru Fukuchi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Myosin Light Chains ,Myocardial Infarction ,Myosins ,Scintigraphy ,Internal medicine ,Myosin ,Organometallic Compounds ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Myocardial infarction ,Myosin light chain I ,Aged ,Hibernating myocardium ,Immunoradiometric assay ,medicine.diagnostic_test ,business.industry ,Antimyosin antibody ,Antibodies, Monoclonal ,General Medicine ,Middle Aged ,medicine.disease ,Endocrinology ,Immunology ,Female ,medicine.symptom ,business - Abstract
Myocardial accumulation of In-111-antimyosin (InAM) was evaluated in comparison with circulating serum myosin light chain I (LCI) level at the time of InAM injection. Seventeen consecutive patients were studied at various stages ranging from 6 days to 34 days after myocardial infarction (MI). The infarct area was positive for InAM uptake in all patients (100%), and significant myocardial uptake was observed in 14 patients (82.4%). The intensity of InAM uptake correlated with the infarct location shown by ECG and CAG. In contrast, 12 patients (70.6%) had normal or undetectable serum myosin LCI levels, with 5 being normal (0.42–2.5 ng/ml) and 7 undetectable (0.42 ng/ml or less). Only 5 patients (29.4%) had elevated serum myosin LCI levels at the time of InAM injection, and this elevation was slight, ranging from 3.4 to 4.5 ng/ml (mean: 3.75 ng/ml). Among patients with undetectable, normal, and elevated serum myosin LCI levels, there was no significant correlation between InAM uptake and the serum myosin LCI level. Thus, even after the serum myosin LCI level has decreased to normal, InAM can still bind to cardiac myosin in patients with MI, presumably until there is complete recovery from the hibernating myocardium due to ischemic damage.
- Published
- 1992
25. Positive indium-111 leukocyte imaging in post myocardial infarction syndrome
- Author
-
Kiyomitsu Ikeoka, Hiroyuki Maeda, Minoru Fukuchi, Aya Miyoshi, Hitoshi Naruse, Kazuhiro Fujitani, Mitsumasa Ohyanagi, Tadaaki Iwasaki, and Seinosuke Kawashima
- Subjects
Male ,Tomography, Emission-Computed, Single-Photon ,medicine.medical_specialty ,Specific test ,business.industry ,Mechanism (biology) ,Indium Radioisotopes ,Myocardial Infarction ,General Medicine ,Syndrome ,Oxyquinoline ,Post myocardial infarction ,Text mining ,Internal medicine ,Cardiology ,Leukocytes ,Organometallic Compounds ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,business ,Aged - Abstract
The diagnosis of post myocardial infarction syndrome (PMIS) is sometimes difficult because of the absence of a specific test. We report a 68-year-old man with PMIS who had a persistent accumulation of indium-111 oxine labeled leukocytes in the infarcted myocardium for 1 month. The uptake of leukocytes preceded the appearance of the main symptoms and disappeared with the clinical improvement after the therapy with steroids. Leukocyte imaging has a potential as a useful tool for early diagnosis, evaluation of therapy and assessing the mechanism of PMIS.
- Published
- 1990
26. Prediction of functional recovery and prognosis in patients with acute myocardial infarction using 123I-BMIPP and thallium-201 spect: A multi center trial by 14 instituions
- Author
-
T Matsumura, K Terada, T. Osada, Nobukazu Takahashi, Hiroki Sugihara, Shigeyuki Nishimura, K Kitahara, T Ito, Hitoshi Naruse, K Imai, T Kajiya, N Iwabuchi, Tsunehiko Nishimura, and Hiroshi Yoshida
- Subjects
medicine.medical_specialty ,business.industry ,chemistry.chemical_element ,medicine.disease ,Functional recovery ,123i bmipp ,chemistry ,Internal medicine ,medicine ,Cardiology ,Thallium ,Radiology, Nuclear Medicine and imaging ,In patient ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business - Published
- 1997
- Full Text
- View/download PDF
27. 913-116 Quantitative Comparison of Planar and SPECT Normal Databases of Thallium-201, Sestamibi, Tetrofosmin and Furifosmin
- Author
-
Frans J. Th. Wackers, Diwakar Jain, Albert J. Sinusas, Edouard Daher, Donna Natale, and Hitoshi Naruse
- Subjects
Short axis ,Database ,medicine.diagnostic_test ,business.industry ,Significant difference ,Anterior wall ,chemistry.chemical_element ,Marked effect ,computer.software_genre ,Myocardial perfusion imaging ,chemistry ,Medicine ,Thallium ,Cardiology and Cardiovascular Medicine ,business ,computer ,Back projection - Abstract
For quantification of planar and SPECT myocardial perfusion imaging lower limits of normal (LLN) are generated for each specific radiotracer from normal subjects. It is unclear how LLN for TI-201 (TI), Tc-99m-Sestamibi (MB), Tc-99m-Tetrofosmin (TF) and Tc-99m-Furifosmin (FF) compare quantitatively Accordingly we performed quantitative comparison of exercise planar (P) and SPECT (SP) in normal subjects (l 3% likelihood CAD) with TI (P:26, SP:26); MB (P:20, SP:28); TF (P:27, SP:42) and FF (P:12, SP:13). LLN (mean – 2sd) were generated using 36-points circumferential count profiles of P views and SP short axis slices, Comparisons were made by unpaired t-tests of each matched data point of 2 radiotracers, Summed t-values g 2 (p l 0,051 represent a measure for point-to-point significant difference between LLN curves, The higher the value the greater the difference. The figure shows t-values for comparison of various tracers for P and SP: Download : Download high-res image (63KB) Download : Download full-size image LLN of various tracers are significantly different from each other and greater for P than for SP. On P imaging differences between TI and Tc-99m agents were primarily at base and anterior wall, whereas on SP no pattern existed. Differences in P imaging may be due to marked effect of interpolative background subtraction, whereas back projection and filtering produces smaller random SP differences. Thus, LLN of various agents are markedly different for P but less for SP. Radiotracer-specific normal databases should be used for quantification of P and SP myocardial perfusion imaging.
- Published
- 1995
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.