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Theodor Kocher (1841-1917), an exceptional Swiss surgeon who described a technique for the safe removal of enlarged thyroid unraveled the true function of this endocrine gland but also made significant contributions to many other fields of surgery. Kocher was the first surgeon awarded the Nobel prize in Physiology and Medicine in 1909 for his work on the physiology, pathology, and surgery of the thyroid gland. He was professor and clinical director at Insel Hospital during 45 years. Kocher created the prominent Surgeon's School in Bern. He was the first president of the International Society of Surgery in 1903 and the founding president of the Swiss Society of Surgery in 1913.

With the majority of eponyms being removed from disease classification systems, it is even more difficult to remember the neurologists who influenced the development of techniques and understanding of the brain over the last centuries. Determining whether Polish researchers were given similar attention to Western equivalents based on eponymic presence in medical databases is an interesting way to provide an overview of unremembered Polish neurologists. This work aims to recognize the developments of forgotten Polish neurologists, whose work, although important, was not properly appreciated over the centuries.

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Understanding Kazakhstan's plague history is crucial for early warning and effective health disaster management. We used descriptive-analytical methods to analyze spatial data for human cases in natural plague foci in Kazakhstan during 1926-2003. The findings revealed 565 human cases across 82 outbreaks in Almaty (32.22%), Aktobe (1.59%), Atyrau (4.42%), Mangystau (21.24%), and Kyzylorda (40.53%) oblasts. Before antibiotic drugs were introduced in 1947-1948, major plague outbreaks occurred in 1926, 1929, 1945, 1947, and 1948, constituting 80.7% of human transmission. Plague spread through flea bites, camel handling, wild animal contact, aerosol transmissions, and rodent bites. Patients were up to 86 years of age; 49.9% were male and 50.1% female. Pulmonary cases were reported most frequently (72.4%), and person-to-person infection occurred at an incidence rate of 0.29 cases/10,000 population. Risk increased with human expansion into natural plague foci areas. Swift diagnosis and treatment are essential for curbing plague outbreaks in Kazakhstan.

The heart is a remarkable organ from both a scientific and functional standpoint, as well as a symbolic representation of many noble elements of human concern found in poetry, art, and religion. Cinema, a form of art in and of itself, has also taken an interest in the heart. Recently, a TV series dedicated to this organ has combined historical research on the groundbreaking development of the possibility of curing it with the romantic element of the love affair that, in a figurative sense, passes through the same organ. About 75 years ago, cardiology began to evolve and culminate in cardiac surgery, which has since spread quickly throughout the globe, including Italy. Fiction is an enjoyable and easily accessible instrument that tells the tale of the creation and quick evolution of cardiology. It is undoubtedly a superb educational medium that helps both the younger and older generations learn about, understand, and value our heritage.

We review and salute the third edition of E.B. Wilson's "The Cell in Development and Heredity" published a century ago, noting its unique features and placing them in context. Brief commentaries from colleagues convey how they have encountered and have been influenced by The Cell . Although soon to be 100 years old, Wilson's 1925 edition is a hallmark of our profession, reminding us of a time when certain scholars were able to advance knowledge with a singularity of both mind and pen. Our purpose is to acknowledge the accomplishment by the man who brought together so many different facets of understanding cells and who many regard as the founder of cell biology in the United States. We reflect on the volume's admirable success and bring together perspectives on why it still matters., Competing Interests: Conflicts of interests: The authors declare no financial conflict of interest.

This history page in the series "Leaders in MSK Radiology" is dedicated to the achievements of Swiss radiologist Hans Rudolf Schinz. He is considered the father of Swiss academic radiology but was also influential internationally. Schinz expanded radiologic science into the fields of epidemiology and the natural sciences. He also advanced radiology and medicine in general through his political activities., Competing Interests: None declared., (Thieme. All rights reserved.)

A 14-year boy is given a microscope by his parents. It is not a toy - but a real microscope. He deploys it to rediscover the biology he had known before, but now in a magnified world. With extraordinary intellectual gifts he then, and manifestly later becomes absorbed by the idea that all this, however mysterious at first glance, might be subject to rational understanding, with painstaking study. Thus, was the genesis of one of the greatest cell biologists of the 20 th century, Joseph Grafton Gall, who died 12 September 2024, at 96. He had been professionally active up until only a few years ago. There was no one like him in the modern era of cell biology and there will not be another figure like him anytime soon.

Sickle cell disease (SCD) is marked by red blood cells that deform into a sickle shape, causing severe health complications. Historic neglect and slow therapeutic progress have left many, especially African descendants, vulnerable. Recent treatment strides include novel drugs and gene therapy, promising improved management. Nonetheless, challenges persist with treatment adoption because of cost, adverse effects, and accessibility. Advancements hold hope for enhanced life quality and longevity for SCD patients., Competing Interests: Disclosure Dr R. Walia and Dr D.E. Sabath do not have any financial disclosures. Dr K.Y. Fertrin has received research support (Agios Pharmaceuticals, United States), consultancy fees (Sanofi Genzyme, Agios Pharmaceuticals), and speaker fees (Agios Pharmaceuticals)., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Transvenous lead extraction (TLE) has evolved significantly since the introduction of cardiac pacing systems in the 1950s. The need for TLE has grown due to the increasing complexity of cardiac devices and patients, alongside rising infection rates and regulatory recalls. Despite its challenges, improved institutional support and advanced training programs have made TLE more accessible. Modern TLE indications are well-defined, evolving through scientific statements to include comprehensive lead management best practices and safety protocols. However, underutilization persists, particularly in infection management, highlighting the need for continued education and adherence to guidelines., Competing Interests: Disclosure Dr R.D. Schaller and Dr A. Kroman receive speaking honoraria from Philips., (Copyright © 2024 Elsevier Inc. All rights reserved.)

John Schulenberg has had significant impact on developmental science. His conceptual writing and empirical research, grounded in developmental contextualism, emphasized the critical role that developmental transitions play in shaping health risks, especially substance use, across the life course. Schulenberg's integration of developmental concepts with large-scale epidemiological studies, particularly through his leadership in the Monitoring the Future study, provides key insights into how significant life changes-such as school transitions, employment, and relationships-interact to influence well-being across adolescence and early adulthood. He was a fierce advocate for adolescence and young adulthood being critical phases of life, deserving of focused attention and support. John was also a devoted mentor to the next generation of developmental scientists. This commentary reflects on John Schulenberg's legacy, highlighting five of his foundational concepts (developmental tasks, transitions, trajectories, turning points, and timing) and celebrating his role as a generative and joyful mentor. He fostered open intellectual dialog, promoted and celebrated career development, and took pleasure in life inside and outside work, helping early career scientists to develop innovative and impactful research programs. Schulenberg's commitment to positive relationships and celebrating success is an enduring model for future generations of developmental scientists and mentors., (© 2024 The Author(s). Journal of Research on Adolescence published by Wiley Periodicals LLC on behalf of Society for Research on Adolescence.)

Background: The National Library of Medicine's Integrated Academic/Advanced Information Management Systems (IAIMS) initiative played a central role in the evolution of health informatics over the project's lifetime (1983-2009) and continues to do so., Aim: Our objective is to demonstrate how IAIMS and two key IAIMS concepts, integration and outreach, have functioned at very different times during this evolutionary process., Approach: Using a framework drawn from Lorenzi and Stead's 2021 history of IAIMS, we examine the role of integration and outreach in work at the University of Maryland Baltimore (UMB) in the early 1980s and at the University of Texas Arlington (UTA) in 2020., Results: Guided by these concepts, UMB implemented a campus-wide information utility, while UTA established a center to accelerate research and innovation., Conclusions: Outreach and integration have been formative in the evolution of health informatics and will continue to hold their power., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Introduction and Aim of the Study: This contribution explores the many pathologies that plague the existence of the renowned Mexican artist Frida Kahlo (1907-1954) and the impact they had on her character., Methodology and Results: Moving from a mere pathobiographical reassessment, this note, through historico-medical research, highlights the patient-physician relationship that the painter developed with Dr. Leo Eloesser (1881-1976) and underlines the role this form of friendship may play in patients' wellbeing., Conclusion: The special friendship between the artist/patient, Frida Kahlo, and her physician, Dr. Eloesser, shows that medicine is not just the sum of diagnoses and therapies but a much more dynamic and complex process involving trust and humane qualities., Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Introduction: The structure of medical residency in the United States has experienced significant changes, paralleling advances in medical science and education. While these changes have enhanced medical training, they have introduced challenges, particularly in resident wellness. The well-being of residents is critical for patient care and the healthcare system. This review aims to provide an overview of the historical trends in medical residency, focusing on the evolution of resident wellness and its associated challenges., Methods: A narrative review was conducted, examining the evolution and challenges of medical residency with an emphasis on resident wellness. An exhaustive literature search on January 25, 2024 was conducted across PubMed, Web of Science, and Google Scholar. The search utilized keywords related to medical residency, wellness, and educational reforms. Articles were selected based on relevance and robust evidence, and information was organized into thematic categories for narrative synthesis., Results: The search yielded 57 publications that met the inclusion criteria. Historical trends revealed a shift from an apprenticeship model to formalized training programs, with each phase bringing unique challenges to resident wellness. The Flexner Report's influence on standardizing medical education, the rise of modern residency programs, and the recognition of burnout as a significant issue were key developments. Policy changes, technological impacts, and the COVID-19 pandemic have further shaped residency training and wellness. Studies highlight the need for interventions addressing burnout and promoting wellness, with varied approaches across specialties and institutions., Conclusion: Residency burnout has been a growing concern since the 1970s, exacerbated by advancements in medicine, technology, and recent global events like the COVID-19 pandemic. Although awareness has increased, the need remains to address burnout and promote wellness during residency. Further research is warranted to develop effective interventions and adapt training to meet the evolving needs of residents., (Copyright © 2024 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.)

Dr. John Schulenberg (1957-2023) was a brilliant and internationally recognized developmental scientist. In equal measure, he was an outstanding, dedicated, and generous mentor. Through his scholarship and mentorship, his impact on the fields of adolescent and substance use research will be deep and enduring. The overriding theme of his research was illuminating the importance of adolescence in the life course, which he referred to as "Taking the Long View" on adolescence. John's longstanding motivation for this was to answer the question: "Does adolescence matter?" This special issue, which (in addition to this introduction) includes 14 papers and 2 invited commentaries, is designed to honor his scholarship and impact. For this introduction to the special issue, we divide what it means to "Take the Long View" on adolescence into four major themes: (1) Turning points; (2) Developmental disturbances; (3) Continuity and long-term developmental connections; and (4) Heterogeneity in the age curve. We describe these four themes, consider how they connect with the overarching question "Does adolescence matter?," and discuss how the research papers included in this special issue are excellent examples of research inspired by these themes., (© 2024 Society for Research on Adolescence.)

The rat, Rattus norvegicus , has provided an important model for investigation of a range of characteristics of biomedical importance. Here we survey the origins of this species, its introduction into laboratory research, and the emergence of genetic and genomic methods that utilize this model organism. Genomic studies have yielded important progress and provided new insight into several biologically important traits. However, some studies have been impeded by the lack of a complete and accurate reference genome for this species. New sequencing and genome assembly methods applied to the rat have resulted in a new reference genome assembly, GRCr8, which is a near telomere-to-telomere assembly of high base-level accuracy that incorporates several elements not captured in prior assemblies. As genome assembly methods continue to advance and production costs become a less significant obstacle, genome assemblies for multiple inbred rat strains are emerging. These assemblies will allow a rat pangenome assembly to be constructed that captures all the genetic variations in strains selected for their utility in research and will overcome reference bias, a limitation associated with reliance on a single reference assembly. By this means, the full utility of this model organism to genomic studies will begin to be revealed.

On 19 July, 2024, at the age of almost 105 years, Joseph W. Goldzieher, the last survivor of the group of pioneers who created oral contraception, peacefully passed away. Here we briefly reconstruct the salient points in his long, productive life, and highlight his achievements in the development of hormonal contraception. His work is indissolubly enshrined in the complex history of hormonal contraception, from the first, fundamental observations, to the first clinical trials, both in the form of combined oestrogen-progestin oral pills and long-acting injectable contraceptives. After Pincus and his Group created an oral contraceptive containing an oestrogen and a progestin, Goldzieher was the second international scientist to conduct clinical trials of the new modality. He teamed-up with investigators in Mexico creating a fruitful, long-lasting collaboration. They produced evidence that ovulation inhibition could be achieved with all the progestins used at the time. Of importance, he was among the first to explore the possibility of using oestrogens to block ovulation, and developed the concept of sequential contraception. For all this lifetime of work, we believe he deserves to be named a 'giant in reproductive endocrinology'.

Diffusion MRI was introduced in 1985, showing how the diffusive motion of molecules, especially water, could be spatially encoded with MRI to produce images revealing the underlying structure of biologic tissues at a microscopic scale. Diffusion is one of several Intravoxel Incoherent Motions (IVIM) accessible to MRI together with blood microcirculation. Diffusion imaging first revolutionized the management of acute cerebral ischemia by allowing diagnosis at an acute stage when therapies can still work, saving the outcomes of many patients. Since then, the field of diffusion imaging has expanded to the whole body, with broad applications in both clinical and research settings, providing insights into tissue integrity, structural and functional abnormalities from the hindered diffusive movement of water molecules in tissues. Diffusion imaging is particularly used to manage many neurologic disorders and in oncology for detecting and classifying cancer lesions, as well as monitoring treatment response at an early stage. The second major impact of diffusion imaging concerns the wiring of the brain (Diffusion Tensor Imaging, DTI), allowing to obtain from the anisotropic movement of water molecules in the brain white-matter images in 3 dimensions of the brain connections making up the Connectome. DTI has opened up new avenues of clinical diagnosis and research to investigate brain diseases, neurogenesis and aging, with a rapidly extending field of application in psychiatry, revealing how mental illnesses could be seen as Connectome spacetime disorders. Adding that water diffusion is closely associated to neuronal activity, as shown from diffusion fMRI, one may consider that diffusion MRI is ideally suited to investigate both brain structure and function. This article retraces the early days and milestones of diffusion MRI which spawned over 40 years, showing how diffusion MRI emerged and expanded in the research and clinical fields, up to become a pillar of modern clinical imaging., Competing Interests: Declarations. Conflict of interest: The author does not have any conflict of interest to report about this article., (© 2024. The Author(s).)

Purpose: Most ophthalmologists in the United States recognize the name "Bascom Palmer" but few are familiar with the individual for whom the Eye Institute is named. This article reviews the biography of Bascom Headen Palmer, Jr, MD (1889-1954)., Design: Historical review., Methods: Historical documents were reviewed, including the archives of the University of Miami, the Miami Lighthouse for the Blind and Visually Impaired, and other sources., Results: Palmer, born in Lake City, Florida in 1889, was the younger son of a Florida politician. He graduated from what was then called the College of Medicine of the Tulane University of Louisiana (now the Tulane University School of Medicine) in 1914, followed by a 2-year internship at Touro Infirmary, service in the army during World War I, and finally a postgraduate course in ophthalmology at the University of Pennsylvania in 1923. He then moved to Miami, where he became influential in 2 new organizations: the University of Miami, founded in 1925, and the Florida Association of Workers for the Blind (now the Miami Lighthouse for the Blind and Visually Impaired), founded in 1930. He forged collaborations between these 2 organizations which eventually led to the foundation of the eponymous Eye Institute., Conclusions: The decades-long collaboration between the Miami Lighthouse and the University of Miami, facilitated by Palmer, ultimately led to the founding of the Eye Institute., (Copyright © 2024 Elsevier Inc. All rights reserved.)

One of the fundamental innovations of pediatric surgery is hepatic portoenterostomy for biliary atresia, widely known as the Kasai procedure for its originator, Morio Kasai (1922-2008), of Sendai, Japan. It was the first effective operation for the "uncorrectable" form of biliary atresia, where death within months from biliary cirrhosis was certain. His radical premise was that microscopic ductules present in the fibrous tissue of the porta hepatis, when transected, drained enough bile to relieve cholestatic jaundice. His first operations from 1955 to 1961 had a jaundice-free survival rate of only 8 percent, but the cures were durable. By 1982-1986 survival reached 55 percent. Adoption of his procedure in the West came slowly. The original operation in 1955 was reported in the Japanese literature in 1959, but the first English language communication came in 1968. Surgeons disbelieved his results. Scientific chauvinism held that advances in pediatric surgery came from America and Europe; Japan had little to add. Surgeons visited Sendai to learn from Kasai, notably John Lilly and R. Peter Altman, then of Washington, DC, Jacques Valayer in Paris, and Edward Howard in London. At first, mortality rates in their hands was high. As expertise developed in the West with the technically demanding operation, mortality fell and approached those reported by Kasai. Successes in America, France, and England proved Kasai's operation as effective and one of signal achievements in pediatric surgery., Competing Interests: Conflicts of interest The author declares no conflicts of interest in the preparation and submission of this article., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Psychiatric clinical diagnostic formulation has evolved over time. The changes alter our understanding and our ability to provide a public health perspective on the epidemiology of mental disorders in large populations. Epidemiology is an important perspective and set of tools to assess prevalence, treated prevalence, untreated prevalence, individual risks for mental disorders, and possible links to the etiology of disorders by following the trails of environmental exposures, biological measures, interpersonal dynamics, and genetic risk factors. As communities develop health-care services to treat individuals with mental disorders, knowledge about their prevalence and treatment requirements is also important. Since severe mental disorders may require institutional care, the diagnostic criteria used may either protect an individual's liability for dangerous behavior (i.e. the insanity defense) or be used to control political and social dissidents. The criteria may also be used to determine evidence-based treatment options and eligibility for disability benefits. In this paper, using my vantage points as a physician scientist and public health officer, with leadership positions in national federal and professional mental health organizations, I address the developments in these areas over the past 50 years that have influenced institutional positions in the U.S. National Institute of Mental Health, the World Health Organization, the American Psychiatric Association, and the Center for the Study of Traumatic Stress. These perspectives may aid the next generation of investigators to advance the epidemiological and mental disorder classification scientific fields.

The cloning of leptin 30 years ago in 1994 was an important milestone in obesity research. Prior to the discovery of leptin, obesity was stigmatized as a condition caused by lack of character and self-control. Mutations in either leptin or its receptor were the first single gene mutations found to cause severe obesity, and it is now recognized that obesity is caused mostly by a dysregulation of central neuronal circuits. Since the discovery of the leptin-deficient obese mouse (ob/ob) the cloning of leptin (ob aka lep) and leptin receptor (db aka lepr) genes, we have learned much about leptin and its action in the central nervous system. The first hope that leptin would cure obesity was quickly dampened because humans with obesity have increased leptin levels and develop leptin resistance. Nevertheless, leptin target sites in the brain represent an excellent blueprint to understand how neuronal circuits control energy homeostasis. Our expanding understanding of leptin function, interconnection of leptin signaling with other systems and impact on distinct physiological functions continues to guide and improve the development of safe and effective interventions to treat metabolic illnesses. This review highlights past concepts and current emerging concepts of the hormone leptin, leptin receptor signaling pathways and central targets to mediate distinct physiological functions., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Heike Muenzberg reports financial support was provided by National Institutes of Health. Christopher D Morrison reports financial support was provided by National Institutes of Health. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Inc.)

Background: Glenohumeral instability is a common pathology, particularly in young, active patients., Methods: A narrative review was performed to describe the history of surgical treatments for anterior shoulder instability., Results: Open surgical techniques were first described by Bankart in 1923. Techniques include both anatomic soft tissue repairs and nonanatomic procedures to provide constraint to motion and dislocation. Osseous techniques to address glenoid bone loss include both autograft techniques, such as the Latarjet procedure, and the use of various allografts. Technologic advances, particularly arthroscopy, have continued to drive the evolution of treatments. The concept of the glenoid track has furthered our understanding of this pathology to guide appropriate treatment to reduce recurrence., Conclusions: Surgical treatment for anterior shoulder instability continues to evolve in an effort to restore function and prevent additional injury., (Copyright © 2024 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.)

In 1924, at the University Hospital of Jena, Hans Berger first recorded an electrical brain signal in humans. This discovery revolutionized clinical neuroscience and neurotechnology, as it contributed to both electrophysiology and the development of the electroencephalogram (EEG). This article provides a historical overview of Hans Berger's seminal contributions, highlighting the importance of his early recordings, the motivations that drove him, and the scientific problems he had to initiate and solve, in a historical context of profoundly changing circumstances. He also faced low acceptance of his works initially, and only belatedly did they become accepted by the scientific community. Berger was known to be a humble but tenacious person who believed in his convictions to the core, and this strength of will is an example of passion for students and scholars of neuroscience. NEW & NOTEWORTHY In 1924, at the University Hospital in Jena, Hans Berger first recorded human brain electrical signals, revolutionizing clinical neurophysiology and neurotechnology. He developed the electroencephalogram (EEG) and identified alpha waves in the human scalp. Although initially met with skepticism, his work was later recognized as fundamental. Berger's perseverance and conviction in his research serve as an inspiring example of dedication for students and scientists in neuroscience.

Dr. Harish Chandra Pant was Chief of the Section on Neuronal Cytoskeletal Protein Regulation within the National Institute of Neurological Disorders and Stroke at the NIH. A main focus of his group was understanding the mechanisms regulating neuronal cytoskeletal phosphorylation. Phosphorylation of neurofilaments can increase filament stability and confer resistance to proteolysis, but aberrant hyperphosphorylation of neurofilaments can be found in the neurofibrillary tangles that are seen with neurodegenerative diseases like Alzheimer disease (AD). Through his work, Harish would inevitably come across cyclin dependent kinase 5 (Cdk5), a key kinase that can phosphorylate neurofilaments at KSPXK motifs. Cdk5 differs from other Cdks in that its activity is mainly in post-mitotic neurons rather than being involved in the cell cycle in dividing cells. With continued interest in Cdk5, Harish and his group were instrumental in identifying important roles for this neuronal kinase in not only neuronal cytoskeleton phosphorylation but also in neuronal development, synaptogenesis, and neuronal survival. Here, we review the accomplishments of Harish in characterizing the functions of Cdk5 and its involvement in neuronal health and disease., (© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)

Dr William J. Mills Jr., an Alaskan orthopedic surgeon, helped establish the current protocols for frostbite treatment and changed a dogma used for more than 140 years that was established by Napoleon's surgeon general of the army, Baron Dominique-Jean Larrey. During Napoleon's 1812 siege of Moscow, Larrey noticed the destructive effects of using open fire heat for warming frozen body parts, so he suggested rubbing snow or immersion in cold water. Dr Mills treated many cold injuries during his medical career. After setting up his medical practice in Anchorage, Alaska, he realized the inefficiency of the established protocols and started researching new treatments for frostbite. Dr Mills followed Meryman's method of rapidly thawing frozen red blood cells in warm water. Mills and his colleagues established a treatment protocol for freezing cold injury that included rapid warming in warm water. These studies resulted in the publication of three key papers in 1960 and 1961. These papers were the first clinical studies that described rapid warming as a treatment. Subsequently, rapid warming, with some variation in water temperatures, has been accepted as the standard of treatment. Due to his outstanding contribution to the treatment of frostbite, he has been referred to as "the nation's leading authority on cold injury." Mills and his colleagues created a new classification system that divided frostbite into two levels, superficial and deep, which was more applicable in clinics than the traditional 4-tier classification. The 2-tier classification is still useful outside of the hospital setting., Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Abstract: In this essay, the author, Dr. Louis Sullivan, describes his life experiences, having been born in the American South during the period of legal racial segregation. Despite many obstacles, Dr. Sullivan became a physician who founded the predominantly Black Morehouse School of Medicine and served as Secretary of the United States Department of Health and Human Services.In his efforts to improve the health of people from historically marginalized groups, including Black and Brown people as well as those experiencing poverty, Dr. Sullivan organized the Association of Minority Health Professions Schools. He chaired the Sullivan Commission to evaluate the strategies developed to increase the number of Black physicians in the nation. He supported development of the Office for Women's Health and led efforts to create the National Institute for Minority Health and Health Disparities, both at the National Institutes of Health. When reflecting on his achievements, Dr. Sullivan cites his many mentors and allies who supported him in his career.Despite significant, ongoing resistance to current efforts to advance diversity, equity, and inclusion in our society, Dr. Sullivan is optimistic that progress toward this goal will continue to be made. He imparts lessons about persistence and positivity and reflects on several initiatives to advance diversity, equity, and inclusion in the health professions and in our society more broadly., (Copyright © 2024 the Association of American Medical Colleges.)

In this article we analyze the classic Hodgkin and Keynes 1955 paper describing investigations of the independence principle, with the expectation that there is much students and educators can learn from such exercises, most notably how the authors applied their diverse skill set to tackling the numerous obstacles that the study presented. The paper encompasses three of the physiology core concepts, cell membranes, flow down gradients, and scientific reasoning, which were recently assigned to the classes The Biological World, The Physical World, and Ways of Looking at the World, respectively. Thus, analysis of such a paper illuminates the relationships that exist between distinct concepts and encourages a holistic approach to understanding physiology. In-depth analysis of the paper allows us to follow the authors' thought processes from their realization that previous methods lacked the resolution to answer a fundamental question relating to ion movement across membranes to the application of a more sensitive technique and ultimately the development of a novel model describing ion flux. This paper was the culmination of work started in the mid-1930s, strongly supported the ionic theory of nervous conduction proposed by Hodgkin and Huxley, and predicted the presence of ion channels as narrow pores through which ions move sequentially four decades before these features were convincingly demonstrated. NEW & NOTEWORTHY We describe in detail Hodgkin and Keynes' investigation of the independence principle. It is our expectation that students and educators can benefit from following the thought processes applied by the authors as they navigated the complexities of experimental design and data analysis, culminating in development of a model whose elegant simplicity was convincing evidence of narrow membrane-bound pores, ion channels, that were the conduit for transmembrane ion movement.

Oswald Schmiedeberg was born in one of the former Baltic provinces of Russia. He studied medicine in Dorpat (Tartu) and joined the Institute of Pharmacology of Rudolf Buchheim in Dorpat. After promotion (1866) and habilitation (1868), he succeeded Buchheim as director of the institute. During this time, he further developed the experimental methods leading to the improvement of pharmacological knowledge introduced by Buchheim. In 1872, he became director of the Institute of Pharmakologie of the newly founded Kaiser-Wilhelm University in Strasbourg. He held this position for over 42 years until the end of the World War 1 when all Germans had to leave the former Reichsland Elsass-Lothringen. He settled next to his friend and colleague Naunyn in Baden-Baden, where he died in 1921. Holmstedt and Liljestrand's (1963) History of Pharmacology and Toxicology noted, "Schmiedeberg was undoubtedly the most prominent pharmacologist of his time." He had about 120 pupils, about 40 of them occupied pharmacology chairs throughout the world. In the USA, John Jacob Abel, after his return to the USA, became the "father of American pharmacology". In 1873, Schmiedeberg, together with the pathologist Klebs (Prague) and the clinician Naunyn (Königsberg), founded the Archiv für experimentelle Pathologie und Pharmakologie. When Naunyn died in 1925, the periodical was named Naunyn-Schmiedeberg's Archiv, from volume 110 onwards. In 1969, the designation "experimental pathology" was dropped, since nearly all papers submitted for some time past dealt with pharmacology. In 1883, Schmiedeberg published the Grundriss der Arzneimittellehre, the later edits with the title Grundriss der Pharmakologie in Bezug auf Arzneimittellehre und Toxikologie., Competing Interests: Declarations. Ethical approval: Not applicable. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)

Parkinson's disease (PD) is characterized by the loss of the dopaminergic nigrostriatal pathway which has led to the successful development of drug therapies that replace or stimulate this network pharmacologically. Although these drugs work well in the early stages of the disease, over time they produce side effects along with less consistent clinical benefits to the person with Parkinson's (PwP). As such there has been much interest in repairing this pathway using transplants of dopamine neurons. This work which began 50 years ago this September is still ongoing and has now moved to first in human trials using human pluripotent stem cell-derived dopaminergic neurons. The results of these trials are eagerly awaited although proof of principle data has already come from trials using human fetal midbrain dopamine cell transplants. This data has shown that developing dopamine cells when transplanted in the brain of a PwP can survive long term with clinical benefits lasting decades and with restoration of normal dopaminergic innervation in the grafted striatum. In this article, we discuss the history of this field and how this has now led us to the recent stem cell trials for PwP., (© 2024 The Author(s). BioEssays published by Wiley Periodicals LLC.)

Stem cell research is the product of cumulative, integrated effort between and within laboratories and disciplines. The many collaborative steps that lead to that special "Eureka moment", when something that has been a puzzle perhaps for years suddenly become clear, is among the greatest pleasures of a scientific career. In this essay, the serendipitous pathway from first acquaintance with pluripotent stem cells to advanced cardiovascular models that emerged from studying development and disease will be described. Perhaps inspiration for later generations of stem cell researchers simply to follow whatever they find interesting., (© 2024 The Authors. BioEssays published by Wiley Periodicals LLC.)

Waste management has been developing in response to needs. The need to get rid of unwanted materials has always been a motivation but using the resource value of waste has also been a driver from the stone age and forwards. In affluent times not so much. Sanitation became a motivation with the discovery of pathogenic microorganisms in the mid-19th century, and after World War 2 (WW2) a strong focus on environmental protection developed, and in recent times, the resource aspect has received an interest despite material affluence. Legislation has been one of the drivers for recent developments, in the case of Sweden, the environmental protection legislation came in the late 1960s, and a few years later, the municipalities got the exclusive right to collect and manage household waste. Many local and regional waste management companies were established, owned by the municipalities. These organizations became agents of development, due to the increased scope and capacity. Adding to the environmental protection agenda, a renewed interest in waste as a resource was initiated by the oil crises of the 1970s, resulting in new waste incineration plants, with energy recovery, connected to already existing district heating networks. Mistakes, failures and alarms in the 1970s and the 1980s resulted in treatment method improvements and the establishment of source separation as an integral part of waste management. The waste management community stands strong today and is taking a more proactive role than before, which includes a stronger focus on communication with other stakeholders., Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Millions of individuals around the world are afflicted with Parkinson's disease (PD), a prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, a distinguished professor and neurologist, has made substantial advancements in the domain of PD research, encompassing both fundamental scientific investigations and practical applications. His research has illuminated the etiology and treatment of PD, as well as the function of energy metabolism and premotor symptoms. As a precursor to a number of neurotransmitters and neuromodulators that are implicated in the pathophysiology of PD, he has also investigated the application of tryptophan (Trp) derivatives in the disease. His principal findings and insights are summarized and synthesized in this narrative review article, which also emphasizes the challenges and implications for future PD research. This narrative review aims to identify and analyze the key contributions of Reichmann to the field of PD research, with the ultimate goal of informing future research directions in the domain. By examining Reichmann's work, the study seeks to provide a comprehensive understanding of his major contributions and how they can be applied to advance the diagnosis and treatment of PD. This paper also explores the potential intersection of Reichmann's findings with emerging avenues, such as the investigation of Trp and its metabolites, particularly kynurenines, which could lead to new insights and potential therapeutic strategies for managing neurodegenerative disorders like PD., (© 2024. The Author(s).)

The shortcomings of expense, power requirements, infection, durability, size, and blood trauma of current durable LVADs have been recognized for many years. The LVADs of tomorrow aspire to be fully implantable, durable, mitigate infectious risk, mimic the pulsatile nature of the native cardiac cycle, as well as minimize bleeding and thrombosis. Power draw, battery cycle lifespan and trans-cutaneous energy transmission remain barriers to completely implantable systems. Potential solutions include decreases in pump electrical draw, improving battery lifecycle technology and better trans-cutaneous energy transmission, potentially from Free-range Resonant Electrical Energy Delivery. In this review, we briefly discuss the history of LVADs and summarize the LVAD devices in the development pipeline seeking to address these issues., Competing Interests: Declarations. Conflicts of interest: None to disclose., (© 2024. The Japanese Society for Artificial Organs.)

Swedish neuroscientist Bror Anders Rexed lived between 1914 and 2002. He was a renowned neuroscientist and a politician who packed a lot into his 88-year life. Bror Rexed is best known for his works on the description of the cytoarchitectonic organization of the cat spinal cord. Rexed laminae as an eponym is a historical landmark for the spinal cord cytoarchitecture. Rexed's name (particularly his surname) has also been linked to the du-reform in Swedish. In this article, we focus on his works on the central and peripheral nervous systems and translational approaches for neurosurgery, as well as his influence on health policies in Sweden., Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

STS theories of biocapital conceptualize how biomedical knowledge and capital form together. Though these formations of biocapital often are located in large urban centers, few scholars have attended to how they are transforming urban spaces and places. In this paper we argue that the twinned technological development of cells and cities concentrates economic and symbolic capital and sets in motion contentious practices we name urban biopolitics . We draw on archival research and a nearly decade-long ethnography of the expansion of biomedical campuses in a major American city to show how the speculative logics of land development and biomedical innovation become bound together in a process we describe as speculative revitalization . We examine how the logics of speculative revitalization imagine a future in which cities and biomedicine produce wealth and health harmoniously together. However, in practice-as buildings of new biomedical urban campuses get built-the dreams of billionaire philanthrocapitalists to create global cities clash with the plans of biomedical researchers to create global health. We document the reproduction of stratified and racialized biomedical exclusions that result while also highlighting the unlikely opportunities for creating alliances committed to creating equitable biomedical research and healthcare in urban communities.

In Chile, a long and oppressive military regime (1973-1990) dismantled emergent initiatives for the deinstitutionalisation of psychiatric care, imposing a neoliberal constitution that opened public services to market forces and limited the state's role in health and social care. After being associated with communism and socialism, community-based mental health work was banned, and socialist psychiatrists were silenced through torture or exile. However, some therapeutic initiatives persisted, such as the "Protected Commune" (PC) initiative within the El Peral psychiatric asylum. The PC attempted to mimic a real town inside the asylum's gated perimeter. It featured an ecumenical chapel, a school, and various "council" departments like recreation, education, waste, economy, and health. Paths received names, wards became districts, and patients and workers were assigned new, democratic roles, all while the authoritarian regime entirely controlled the "outside" world. The initiative ceased with the return of democracy in 1990. Deemed an eccentric and negligible episode, the PC is often seen as an interruption to the radical community-based experiences of the pre-dictatorial era. Drawing on archival research and oral history interviews with participants, this paper examines how the PC harnessed the notion of community to navigate the complex socio-political landscape of the dictatorship. Differing from established accounts of the political uses of psychiatry under authoritarianism, the study positions the PC as a prism for understanding the contradictory ways in which the idea of 'community' has been able to transcend radically opposed social and political regimes, becoming a core feature in the vocabulary of mental health reform, despite its ambiguities., Competing Interests: Declarations Conflict of interest No conflict of interest., (© 2024. The Author(s).)

In this essay, the author examines a highly influential poem, The Age of Anxiety by W.H. Auden, for its engagement with anxiety and religious faith in the modern world. Published in 1947, the book-length poem reveals Auden's deep understanding of western psychology, Judaism, and Christianity. The author argues for the relevance of The Age of Anxiety in this modern moment, but demonstrates that this relevance does not derive from any direct diagnostic or therapeutic implications of the poem. Rather, Auden's work provides readers with an image of a state of grace in the middle of an age of anxiety., Competing Interests: Declarations Conflict of interest The author has no relevant financial or non-financial conflicts of interest to disclose. Ethical approval This work involved no human or animal subjects, no funding, and no potential conflicts of interest., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)