1. [Calciphylaxis of the skin as a sequela of terminal kidney failure. Report and discussion of 3 cases].
- Author
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Hiss U, Tronnier M, Rob PM, Gutsche HU, and Wolff HH
- Subjects
- Aged, Calciphylaxis pathology, Calciphylaxis therapy, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 1 pathology, Diabetes Mellitus, Type 1 therapy, Diabetic Nephropathies pathology, Diabetic Nephropathies therapy, Female, Humans, Kidney Failure, Chronic pathology, Kidney Failure, Chronic therapy, Leg Ulcer pathology, Leg Ulcer therapy, Male, Middle Aged, Muscle, Smooth, Vascular pathology, Necrosis, Skin blood supply, Skin pathology, Skin Diseases pathology, Skin Diseases therapy, Calciphylaxis etiology, Diabetic Nephropathies complications, Kidney Failure, Chronic complications, Leg Ulcer etiology, Skin Diseases etiology
- Abstract
Calciphylaxis is a rare syndrome mostly affecting patients with secondary hyperparathyroidism and in some cases with functional protein C or protein S deficiency. Skin lesions begin as superficial painful patches that progress to deep necrotic lesions. The findings are often misdiagnosed as livedo vasculitis and the prognosis is poor. Histopathologically, calcification in the media of small arteries and arterioles with intimal hyperplasia is seen. It is unclear if this morphologic hallmark is pathogenetic. Therapeutically, the calcium-phosphate product should be lowered pharmacologically by an intensified and modified dialysis treatment and parathyroidectomy.
- Published
- 1999
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