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128 results on '"Hiss M"'

6. ANCA-positivity and efficacy of Rituximab in IgG4-related disease

Author

Ronicke, S, Bräsen, JH, Hiß, M, Haller, H, and Wagner, AD

Subjects
ddc: 610, integumentary system, fungi, parasitic diseases, 610 Medical sciences, Medicine, skin and connective tissue diseases
Abstract

Introduction: IgG4-related disease (IgG4-RD) is an inflammatory multiorgan condition with diverse phenotype [ref:1]. IgG4-RD is characterized by elevated serum IgG4 levels and tissue infiltration by IgG4-positive plasma cells [ref:2]. ANCA-positivity in IgG4-RD patients has been [for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)

Published
2020
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9. Multimodal Elimination for Intoxication with a Lethal Dose of Organic Mercury

Author

Napp, L. C., Moelgen, C., Wegner, F., Heitland, P., Koester, H. D., Klintschar, M., Hiss, M., Schaper, A., Schieffer, B., Bauersachs, J., Schäfer, A., and Tongers, J.

Subjects
Article Subject
Abstract

We here report on a case of massive organic mercury intoxication in a 40-year-old man that resulted in progressive multiorgan failure. We treated the patient intravenously and enterally with the chelating agent (RS)-2,3-bis(sulfanyl) propane-1-sulfonic acid (DMPS) in addition to hemodialysis. The patient was treated for 6 weeks and could successfully be weaned from mechanical ventilation and hemodialysis. He awoke and was sent to rehabilitation, but unfortunately died 7 months later from refractory status epilepticus. Autopsy revealed severe brain atrophy consistent with organ damage from massive mercury intoxication. The present case illustrates that bimodal DMPS application is sufficient for detoxification from lethal mercury levels, with an associated chance for weaning of organ support and survival to discharge. The case further reminds us of intoxication as a cause of multiorgan dysfunction. We propose to immediately initiate combined parenteral and enteral detoxification in cases of methyl mercury intoxication, especially in cases of high doses.

Published
2019
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10. The Physcomitrella patens chromosome‐scale assembly reveals moss genome structure and evolution

Author

Lang, D, Ullrich, KK, Murat, F, Fuchs, J, Jenkins, J, Haas, FB, Piednoel, M, Gundlach, H, Van Bel, M, Meyberg, R, Vives, C, Morata, J, Symeonidi, A, Hiss, M, Muchero, W, Kamisugi, Y, Saleh, O, Blanc, G, Decker, EL, Van Gessel, N, Grimwood, J, Hayes, RD, Graham, SW, Gunter, LE, McDaniel, SF, Hoernstein, SNW, Larsson, A, Li, F-W, Perroud, P-F, Phillips, J, Ranjan, P, Rokshar, DS, Rothfels, CJ, Schneider, L, Shu, S, Stevenson, DW, Thümmler, F, Tillich, M, Villarreal Aguilar, JC, Widiez, T, Wong, GK-S, Wymore, A, Zhang, YA, Zimmer, AD, Quatrano, RS, Mayer, KFX, Goodstein, D, Casacuberta, JM, Vandepoele, K, Reski, R, Cuming, AC, Tuskan, GA, Maumus, F, Salse, J, Schmutz, J, and Rensing, SA

Subjects
food and beverages
Abstract

The draft genome of the moss model, Physcomitrella patens, comprised approximately 2000 unordered scaffolds. In order to enable analyses of genome structure and evolution we generated a chromosome‐scale genome assembly using genetic linkage as well as (end) sequencing of long DNA fragments. We find that 57% of the genome comprises transposable elements (TEs), some of which may be actively transposing during the life cycle. Unlike in flowering plant genomes, gene‐ and TE‐rich regions show an overall even distribution along the chromosomes. However, the chromosomes are mono‐centric with peaks of a class of Copia elements potentially coinciding with centromeres. Gene body methylation is evident in 5.7% of the protein‐coding genes, typically coinciding with low GC and low expression. Some giant virus insertions are transcriptionally active and might protect gametes from viral infection via siRNA mediated silencing. Structure‐based detection methods show that the genome evolved via two rounds of whole genome duplications (WGDs), apparently common in mosses but not in liverworts and hornworts. Several hundred genes are present in colinear regions conserved since the last common ancestor of plants. These syntenic regions are enriched for functions related to plant‐specific cell growth and tissue organization. The P. patens genome lacks the TE‐rich pericentromeric and gene‐rich distal regions typical for most flowering plant genomes. More non‐seed plant genomes are needed to unravel how plant genomes evolve, and to understand whether the P. patens genome structure is typical for mosses or bryophytes.

Published
2018

13. Stratigraphy and Ammonite fauna from Campan in North West Munster

Author

Kaplan, U, Kennedy, WJ, and Hiß, M

Abstract

The Campanian ammonite faunas of the north-western Münster Basin are systematically and stratigraphically revised. They comprise 39 species, referred to 29 genera. In addition to the type-material of SCHLÜTER (1867; 1871-1876), the specimens mentioned and figured by WIPPICH (1995) and LOMMERZHEIM (1995) are re-examined and partially refigured. The ammonite occurrences are documented in the context of the detailed lithostratigraphy and a foram zonation of the Campanian of the north western Münster Basin and the Campanian standard zones of north Germany. An ammonite stratigraphy for the Münster Basin Campanian is proposed. The basal Lower Campanian remains unzoned. The Placenticeras bidorsatum-Zone comprises the central division of the Dülmen Formation. In the upper part the first occurrence of Scaphites hippocrepis III marks the base of the eponymous zone. Scaphites gibbus enters at the base of the Asbeck-Member, Holtwick Formation, and defines the succeeding ammonite zone. The base of the Upper Campanian corresponds to the base of the Coesfeld Formation and the lies immediately below the base of the Beckum Member and the entry of several species of Hoplitoplacenticeras. The lower part of the Coesfeld Formation corresponds to the Hoplitoplacenticeras vari Zone, the middle part to the Trachyscaphites spiniger-Zone, and the upper part already belongs to the lower Bostrychoceras polyplocum Zone, which also includes the Baumberge Formation excluding the highest part, which lacks ammonites, and remains undated in ammonite terms.

Published
2016

15. 1D.07

Author

Limbourg, F., primary, Scherer, N., additional, Hiss, M., additional, Haller, H., additional, and Radermacher, J., additional

Published
2015
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16. Cenozoic

Author

Knox, R.W.O.B., Bosch, J.H.A., Rasmussen, Erik Skovbjerg, Heilmann-Clausen, Claus, Hiss, M., De Lugt, I.R., Kasinski, J., King, C., Köthe, A., Slodkowska, B., Standke, G., Vandenberghe, N., Dornenbaal, Hans, and Stevenson, Alan

Published
2010

18. 1D.07

Author

Hiss M, Hermann Haller, Limbourg F, Jörg Radermacher, and Scherer N

Subjects
medicine.medical_specialty, Physiology, business.industry, medicine.medical_treatment, Renal artery stenosis, medicine.disease, Outcome (game theory), Resistive index, Term (time), Internal medicine, Angioplasty, Internal Medicine, Cardiology, medicine, In patient, Cardiology and Cardiovascular Medicine, business
Published
2015

21. Peritoneal dialysis II

Author

Yayar, O., primary, Buyukbakkal, M., additional, Eser, B., additional, Yildirim, T., additional, Ercan, Z., additional, Erdogan, B., additional, Kali, A., additional, Merhametsiz, O., additional, Haspulat, A., additional, Akdag, I., additional, Ayli, M. D., additional, Quach, T., additional, Tregaskis, P., additional, Menahem, S., additional, Koukounaras, J., additional, Mott, N., additional, Walker, R., additional, Zeiler, M., additional, Santarelli, S., additional, Degano, G., additional, Monteburini, T., additional, Agostinelli, R. M., additional, Marinelli, R., additional, Ceraudo, E., additional, Grzelak, T., additional, Kramkowska, M., additional, Walczak, M., additional, Czyzewska, K., additional, Guney, I., additional, Turkmen, K., additional, Yazici, R., additional, Arslan, S., additional, Altintepe, L., additional, Yeksan, M., additional, Vaduva, C., additional, Popa, S., additional, Mota, M., additional, Mota, E., additional, Wan Md Adnan, W. A. H., additional, Zaharan, N. L., additional, Moreiras-Plaza, M., additional, Blanco-Garcia, R., additional, Beato-Coo, L., additional, Cossio-Aranibar, C., additional, Martin-Baez, I., additional, Santos, M. T., additional, Fonseca, I., additional, Santos, O., additional, Aguiar, P., additional, Rocha, M. J., additional, Carvalho, M. J., additional, Cabrita, A., additional, Rodrigues, A., additional, Guo, Z., additional, Lai, X., additional, Theodoridis, M., additional, Panagoutsos, S., additional, Thodis, E., additional, Karanikas, M., additional, Mitrakas, A., additional, Kriki, P., additional, Kantartzi, K., additional, Passadakis, P., additional, Vargemezis, V., additional, Vakilzadeh, N., additional, Pruijm, M., additional, Burnier, M., additional, Halabi, G., additional, Azevedo, P., additional, Carvalho, M., additional, Laplante, S., additional, Rutherford, P., additional, Shutov, E., additional, Isachkina, A., additional, Gorelova, E., additional, Troya, M.-I., additional, Teixido, J., additional, Pedreira, G., additional, Del Rio, M., additional, Romero, R., additional, Bonet, J., additional, Zhang, X., additional, Ma, J., additional, Kim, Y., additional, Kim, J.-K., additional, Song, Y. R., additional, Kim, S. G., additional, Kim, H. J., additional, Eloot, S., additional, Vanholder, R., additional, Van Biesen, W., additional, Heaf, J., additional, Pedersen, C., additional, Elgborn, A., additional, Arabaci, T., additional, Emrem, G., additional, Keles, M., additional, Kizildag, A., additional, Martino, F., additional, Amici, G., additional, Rodighiero, M. P., additional, Crepaldi, C., additional, Ronco, C., additional, Tanaka, H., additional, Tsuneyoshi, S., additional, Yamasaki, K., additional, Daijo, Y., additional, Tatsumoto, N., additional, Al-Hilali, N., additional, Hussain, N., additional, Fathy, V., additional, Negm, H., additional, Alhilali, M., additional, Grzegorzewska, A., additional, Cieszynski, K., additional, Kaczmarek, A., additional, Sowinska, A., additional, Soleymanian, T., additional, Najafi, I., additional, Ganji, M. R., additional, Ahmadi, F., additional, Saddadi, F., additional, Hakemi, M., additional, Amini, M., additional, Tong, L. N. M. N., additional, Yongcheng, H. N. M. N., additional, Qijun, W. N. M. N., additional, Shaodong, L. N. M. N., additional, Velioglu, A., additional, Albaz, M., additional, Arikan, H., additional, Tuglular, S., additional, Ozener, C., additional, Bakirdogen, S., additional, Eren, N., additional, Mehtap, O., additional, Bek, S. G., additional, Cekmen, M. B., additional, Yilmaz, A., additional, Cabana Carcasi, M. L. L., additional, Fernandez Ferreiro, A., additional, Fidalgo Diaz, M., additional, Becerra Mosquera, V., additional, Alonso Valente, R., additional, Buttigieg, J., additional, Borg Cauchi, A., additional, Rogers, M., additional, Buhagiar, L., additional, Farrugia Agius, J., additional, Vella, M. P., additional, Farrugia, E., additional, Han, J. H., additional, Kim, H. R., additional, Ko, K. I., additional, Kim, C. H., additional, Koo, H. M., additional, Doh, F. M., additional, Lee, M. J., additional, Oh, H. J., additional, Han, S. H., additional, Yoo, T.-H., additional, Kang, S.-W., additional, Choi, K. H., additional, Sikorska, D., additional, Frankiewicz, D., additional, Klysz, P., additional, Schwermer, K., additional, Hoppe, K., additional, Nealis, J., additional, Kaczmarek, J., additional, Baum, E., additional, Wanic-Kossowska, M., additional, Pawlaczyk, K., additional, Oko, A., additional, Hiss, M., additional, Gerstein, F., additional, Haller, H., additional, Gueler, F., additional, Fukasawa, M., additional, Manabe, T., additional, Wan, Q., additional, He, Y., additional, Zhu, D., additional, Li, J., additional, Xu, H., additional, Yayar, O., additional, Oztemel, A., additional, Pilcevic, D., additional, Kovacevic, Z., additional, Maksic, D., additional, Paunic, Z., additional, Tadic-Pilcevic, J., additional, Mijuskovic, M., additional, Petrovic, M., additional, Obrencevic, K., additional, Rabrenovic, V., additional, Ignjatovic, L., additional, Terzic, B., additional, Jovanovic, D., additional, Chang, C.-H., additional, Chang, Y.-S., additional, Busuioc, M., additional, Guerraoui, A., additional, Caillette-Beaudoin, A., additional, Bahte, S. K., additional, Kielstein, J. T., additional, Polinder-Bos, H., additional, Emmelot-Vonk, M., additional, and Gaillard, C., additional

Published
2013
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24. AKI - Clinical

Author

Gok Oguz, E., primary, Olmaz, R., additional, Turgutalp, K., additional, Muslu, N., additional, Sungur, M. A., additional, Kiykim, A., additional, Van Biesen, W., additional, Vanmassenhove, J., additional, Glorieux, G., additional, Vanholder, R., additional, Chew, S., additional, Forster, K., additional, Kaufeld, T., additional, Kielstein, J., additional, Schilling, T., additional, Haverich, A., additional, Haller, H., additional, Schmidt, B., additional, Hu, P., additional, Liang, X., additional, Chen, Y., additional, LI, R., additional, Jiang, F., additional, LI, Z., additional, Shi, W., additional, Lim, C. C. W., additional, Chia, C. M. L., additional, Tan, A. K., additional, Tan, C. S., additional, Ng, R., additional, Subramani, S., additional, Perez de Jose, A., additional, Bernis Carro, C., additional, Madero Jarabo, R., additional, Bustamante, J., additional, Sanchez Tomero, J. A., additional, Chung, W., additional, Ro, H., additional, Chang, J. H., additional, Lee, H. H., additional, Jung, J. Y., additional, Fazzari, L., additional, Giuliani, A., additional, Scrivano, J., additional, Pettorini, L., additional, Benedetto, U., additional, Luciani, R., additional, Roscitano, A., additional, Napoletano, A., additional, Coclite, D., additional, Cordova, E., additional, Punzo, G., additional, Sinatra, R., additional, Mene, P., additional, Pirozzi, N., additional, Shavit, L., additional, Manilov, R., additional, Algur, N., additional, Wiener-Well, Y., additional, Slotki, I., additional, Pipili, C., additional, Vrettou, C. S., additional, Avrami, K., additional, Economidou, F., additional, Glynos, K., additional, Ioannidou, S., additional, Markaki, V., additional, Douka, E., additional, Nanas, S., additional, De Pascalis, A., additional, Cofano, P., additional, Proia, S., additional, Valletta, A., additional, Vitale, O., additional, Russo, F., additional, Buongiorno, E., additional, Filiopoulos, V., additional, Biblaki, D., additional, Lazarou, D., additional, Chrysis, D., additional, Fatourou, M., additional, Lafoyianni, S., additional, Vlassopoulos, D., additional, Zakiyanov, O., additional, Kriha, V., additional, Vachek, J., additional, Svarcova, J., additional, Zima, T., additional, Tesar, V., additional, Kalousova, M., additional, Kaushik, M., additional, Ronco, C., additional, Cruz, D., additional, Zhang, L., additional, Zhang, W., additional, Chen, N., additional, Ejaz, A. A., additional, Kambhampati, G., additional, Ejaz, N., additional, Dass, B., additional, Lapsia, V., additional, Arif, A. A., additional, Asmar, A., additional, Shimada, M., additional, Alsabbagh, M., additional, Aiyer, R., additional, Johnson, R., additional, Chen, T.-H., additional, Chang, C.-H., additional, Chang, M.-Y., additional, Tian, Y.-C., additional, Hung, C.-C., additional, Fang, J.-T., additional, Yang, C.-W., additional, Chen, Y.-C., additional, Cantaluppi, V., additional, Quercia, A. D., additional, Figliolini, F., additional, Giacalone, S., additional, Pacitti, A., additional, Gai, M., additional, Guarena, C., additional, Leonardi, G., additional, Biancone, L., additional, Camussi, G., additional, Segoloni, G. P., additional, De Cal, M., additional, Lentini, P., additional, Clementi, A., additional, Virzi, G. M., additional, Scalzotto, E., additional, Lacquaniti, A., additional, Donato, V., additional, Fazio, M. R., additional, Lucisano, S., additional, Cernaro, V., additional, Lupica, R., additional, Buemi, M., additional, Helvaci, I., additional, Anik, E., additional, Wani, M., additional, Wani, D. I., additional, Bhat, D. M. A., additional, Banday, D. K., additional, Najar, D. M. S., additional, Reshi, D. A. R., additional, Palla, D. N. A., additional, Iglesias, P., additional, Olea, T., additional, Vega-Cabrera, C., additional, Heras, M., additional, Bajo, M. A., additional, Del Peso, G., additional, Arias, M. J., additional, Selgas, R., additional, Diez, J. J., additional, Daher, E., additional, Costa, P. L., additional, Pereira, E. N. S., additional, Santos, R. D. P., additional, Abreu, K. L., additional, Silva Junior, G., additional, Pereira, E. D. B., additional, Raimundo, M., additional, Crichton, S., additional, Syed, Y., additional, Martin, J., additional, Whiteley, C., additional, Bennett, D., additional, Ostermann, M., additional, Gjyzari, A., additional, Thereska, N., additional, Koroshi, A., additional, Barbullushi, M., additional, Kodra, S., additional, Idrizi, A., additional, Strakosha, A., additional, Petrela, E., additional, Lemmich Smith, J., additional, Klimenko, A., additional, Tuykhmenev, E., additional, Villevalde, S., additional, Kobalava, Z., additional, Avdoshina, S., additional, Tyukhmenev, E., additional, Efremovtseva, M., additional, Hayashi, H., additional, Suzuki, S., additional, Kataoka, K., additional, Kondoh, Y., additional, Taniguchi, H., additional, Sugiyama, D., additional, Nishimura, K., additional, Sato, W., additional, Maruyama, S., additional, Matsuo, S., additional, Yuzawa, Y., additional, Geraldine, D., additional, Muriel, F., additional, Alexandre, H., additional, Eric, R., additional, Fu, P., additional, Pozzato, M., additional, Ferrari, F., additional, Cecere, P., additional, Mesiano, P., additional, Vallero, A., additional, Livigni, S., additional, Quarello, F., additional, Hudier, L., additional, Decaux, O., additional, Haddj-Elmrabet, A., additional, Mandart, L., additional, Lino-Daniel, M., additional, Bridoux, F., additional, Renaudineau, E., additional, Sawadogo, T., additional, Le Pogamp, P., additional, Vigneau, C., additional, Famee, D., additional, Koo, H. M., additional, Oh, H. J., additional, Han, S. H., additional, Choi, K. H., additional, Kang, S.-W., additional, Mehdi, M., additional, Nicolas, M., additional, Mariat, C., additional, Shah, P., additional, Kute, V. B., additional, Vanikar, A., additional, Gumber, M., additional, Patel, H., additional, Trivedi, H., additional, Manetos, C., additional, Poulaki, S., additional, Tripodaki, E.-S., additional, Papastylianou, A., additional, Routsi, C., additional, Uchida, K., additional, Kensuke, U., additional, Yamagata, K., additional, Saitou, C., additional, Okada, M., additional, Chita, G., additional, Davies, M., additional, Veriawa, Y., additional, Naicker, S., additional, Mukhopadhyay, P., additional, Mukherjee, D., additional, Mishra, R., additional, Kar, M., additional, Zickler, D., additional, Wesselmann, H., additional, Schindler, R., additional, Gutierrez*, E., additional, Egido, J., additional, Rubio-Navarro, A., additional, Buendia, I., additional, Blanco-Colio, L. M., additional, Toldos, O., additional, Manzarbeitia, F., additional, De Lorenzo, A., additional, Sanchez, R., additional, Praga^, M., additional, Moreno^, J. A., additional, Kim, M. Y., additional, Kang, N. R., additional, Jang, H. R., additional, Lee, J. E., additional, Huh, W., additional, Kim, Y.-G., additional, Kim, D. J., additional, Hong, S.-C., additional, Kim, J.-S., additional, Oh, H. Y., additional, Okamoto, T., additional, Kamata, K., additional, Naito, S., additional, Tazaki, H., additional, Kan, S., additional, Anne-Kathrin, L.-G., additional, Matthias, K., additional, Speer, T., additional, Andreas, L., additional, Heinrich, G., additional, Thomas, V., additional, Poppleton, A., additional, Danilo, F., additional, Lai, C.-F., additional, Wu, V.-C., additional, Shiao, C.-C., additional, Huang, T.-M., additional, Wu, K.-D., additional, Bedford, M., additional, Farmer, C., additional, Irving, J., additional, Stevens, P., additional, Patera, F., additional, Mattozzi, F., additional, Battistoni, S., additional, Fagugli, R. M., additional, Park, M. Y., additional, Choi, S. J., additional, Kim, J. G., additional, Hwang, S. D., additional, Xie, H., additional, Chen, H., additional, Xu, S., additional, He, Q., additional, Liu, J., additional, Hu, W., additional, Liu, Z., additional, Dalboni, M., additional, Blaya, R., additional, Quinto, B. M., additional, Narciso, R., additional, Oliveira, M., additional, Monte, J., additional, Durao, M., additional, Cendoroglo, M., additional, Batista, M., additional, Hanemann, A. L., additional, Liborio, A., additional, Martins, A., additional, Pinheiro, M. C. C., additional, Meneses, G., additional, De Paula Pessoa, R., additional, Sousa, M., additional, Bezerra, F. S. M., additional, Albuquerque, P. L. M. M., additional, Lima, J. B., additional, Lima, C. B., additional, Veras, M. D. S. B., additional, Nemoto Matsui, T., additional, Totoli, C., additional, Cruz Andreoli, M. C., additional, Vilela Coelho, M. P., additional, Guimaraes de Souza, N. K., additional, Ammirati, A. L., additional, De Carvalho Barreto, F., additional, Ferraz Neto, B.-H., additional, Fortunato Cardoso Dos Santos, B., additional, Abraham, A., additional, Abraham, G., additional, Mathew, M., additional, Duarte, P. M. A., additional, Duarte, F. B., additional, Barros, E. M., additional, Castro, F. Q. S., additional, Palomba, H., additional, Castro, I., additional, Sousa, S. R., additional, Jesus, A. N., additional, Romano, T., additional, Burdmann, E., additional, Yu, L., additional, Kwon, S. H., additional, You, J. Y., additional, Hyun, Y. K., additional, Woo, S. A., additional, Jeon, J. S., additional, Noh, H. J., additional, Han, D. C., additional, Tozija, L., additional, Petronievic, Z., additional, Selim, G., additional, Nikolov, I., additional, Stojceva-Taneva, O., additional, Cakalaroski, K., additional, Lukasz, A., additional, Beneke, J., additional, Menne, J., additional, Schiffer, M., additional, Polanco, N., additional, Hernandez, E., additional, Gutierrez, E., additional, Gutierrez Millet, V., additional, Gonzalez Monte, E., additional, Morales, E., additional, Praga, M., additional, Francisco Javier, L., additional, Nuria, G.-F., additional, Jose Maria, M.-G., additional, Bes Rastrollo, M., additional, Angioi, A., additional, Conti, M., additional, Cao, R., additional, Atzeni, A., additional, Pili, G., additional, Matta, V., additional, Murgia, E., additional, Melis, P., additional, Binda, V., additional, Pani, A., additional, Thome*, F., additional, Leusin, F., additional, Barros, E., additional, Morsch, C., additional, Balbinotto, A., additional, Pilla, C., additional, Premru, V., additional, Buturovic-Ponikvar, J., additional, Ponikvar, R., additional, Marn-Pernat, A., additional, Knap, B., additional, Kovac, J., additional, Gubensek, J., additional, Kersnic, B., additional, Krnjak, L., additional, Prezelj, M., additional, Granatova, J., additional, Havrda, M., additional, Hruskova, Z., additional, Kratka, K., additional, Remes, O., additional, Mokrejsova, M., additional, Bolkova, M., additional, Lanska, V., additional, Rychlik, I., additional, Uniacke, M. D., additional, Lewis, R. J., additional, Harris, S., additional, Roderick, P., additional, Martin, N., additional, Ulrich, K., additional, Jan, B., additional, Jorn, B., additional, Reinhard, B., additional, Jan, K., additional, Hermann, H., additional, Meyer Tobias, F., additional, Leyla, R., additional, Schmidt Bernhard, M. W., additional, Harald, S., additional, Jurgen, S., additional, Tanja, K., additional, Mario, S., additional, Sang Hi, E., additional, Claus, M., additional, Frank, V., additional, Aleksej, S., additional, Sengul, S., additional, Robert, S., additional, Karin, W., additional, Feikah, G., additional, Menne Tobias, F., additional, Meyer Tobias, N., additional, Beutel, G., additional, Fleig, S., additional, Steinhoff, J., additional, Meyer, T., additional, Hafer, C., additional, Bramstedt, J., additional, Busch, V., additional, Vischedyk, M., additional, Kuhlmann, U., additional, Ries, W., additional, Mitzner, S., additional, Mees, S., additional, Stracke, S., additional, Nurnberger, J., additional, Gerke, P., additional, Wiesner, M., additional, Sucke, B., additional, Abu-Tair, M., additional, Kribben, A., additional, Klause, N., additional, Merkel, F., additional, Schnatter, S., additional, Dorresteijn, E., additional, Samuelsson, O., additional, Brunkhorst, R., additional, Stec-Hus Registry, G., additional, Reising, A., additional, Bange, F.-C., additional, Hiss, M., additional, Vetter, F., additional, Bode-Boger, S. M., additional, Martens-Lobenhoffer, J., additional, Schmidt, B. M. W., additional, Kielstein, J. T., additional, Shin, H. S., additional, Jung, Y. S., additional, and Rim, H., additional

Published
2012
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25. Combination of everolimus with calcineurin inhibitor medication resulted in post-transplant haemolytic uraemic syndrome in lung transplant recipients--a case series

Author

Lovric, S., primary, Kielstein, J. T., additional, Kayser, D., additional, Brocker, V., additional, Becker, J. U., additional, Hiss, M., additional, Schiffer, M., additional, Sommerwerck, U., additional, Haller, H., additional, Struber, M., additional, Welte, T., additional, and Gottlieb, J., additional

Published
2011
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28. Renal side effects of VEGF-blocking therapy

Author

Muller-Deile, J., primary, Brocker, V., additional, Grunwald, V., additional, Hiss, M., additional, Bertram, A., additional, Kubicka, S., additional, Ganser, A., additional, Haller, H., additional, and Schiffer, M., additional

Published
2009
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31. A hopeless case?

Author

Woywodt, A., primary, Schneider, G., additional, Haller, H., additional, and Hiss, M., additional

Published
2007
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34. HUMAN SAFETY AND PHARMACOLOGY OF FTY 720

Author

Brunkhorst, R, primary, Neumayer, H-H, additional, Hiss, M, additional, Budde, K, additional, Lucker, P, additional, Mayer, T, additional, Brookman, L, additional, and Schmouder, R, additional

Published
1999
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35. HUMAN PHARMACOKINETICS OF FTY 720

Author

Neumayer, H-H, primary, Brunkhorst, R, additional, Budde, K, additional, Hiss, M, additional, Lucker, P, additional, Mayer, T, additional, Choudhury, S, additional, Kraus, G, additional, and Schmouder, R, additional

Published
1999
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37. Large scale gene expression profiling data of the model moss Physcomitrella patens help to understand developmental progression, culture and stress conditions

Author

Hiss M, Laule O, Meskauskiene Rm, Arif Ma, Decker El, Erxleben A, Frank W, Hanke St, Lang D, Martin A, Neu C, Reski R, Richardt S, Schallenberg-Rüdinger M, Szövényi P, Tiko T, Wiedemann G, Wolf L, Zimmermann P, and Rensing Sa

Subjects
food and beverages
Abstract

The moss Physcomitrella patens is an important model organism to study plant evolution development physiology and biotechnology. Here we have generated microarray gene expression data covering the principal developmental stages culture forms and some environmental/stress conditions. Example analyses of developmental stages and growth conditions as well as abiotic stress treatments demonstrate that i) growth stage is dominant over culture conditions ii) liquid culture is not stressful for the plant iii) low pH might aid protoplastation by reduced expression of cell wall structure genes iv) largely the same gene pool mediates response to de and rehydration and v) AP2/EREBP and NAC transcription factors play important roles in stress response reactions. With regard to the AP2 gene family phylogenetic analysis and comparison with Arabidopsis thaliana shows commonalities as well as uniquely expressed family members under drought light perturbations and protoplastation. Gene expression profiles for P. patens are available for the scientific community via the easy to use tool at "http://https://www.genevestigator.com" "https://www.genevestigator.com". By providing large scale expression profiles the usability of this model organism is further enhanced e.g. by enabling selection of control genes for quantitative Real Time PCR. Now gene expression levels across a broad range of conditions can be accessed online for P. patens. This article is protected by copyright. All rights reserved.

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38. Multimodal Elimination for Intoxication with a Lethal Dose of Organic Mercury

Author

C. Napp, L., Moelgen, C., Wegner, F., Heitland, P., D. Koester, H., Klintschar, M., Hiss, M., Schaper, A., Schieffer, B., Bauersachs, J., Schäfer, A., and Tongers, J.

Abstract

We here report on a case of massive organic mercury intoxication in a 40-year-old man that resulted in progressive multiorgan failure. We treated the patient intravenously and enterally with the chelating agent (RS)-2,3-bis(sulfanyl) propane-1-sulfonic acid (DMPS) in addition to hemodialysis. The patient was treated for 6 weeks and could successfully be weaned from mechanical ventilation and hemodialysis. He awoke and was sent to rehabilitation, but unfortunately died 7 months later from refractory status epilepticus. Autopsy revealed severe brain atrophy consistent with organ damage from massive mercury intoxication. The present case illustrates that bimodal DMPS application is sufficient for detoxification from lethal mercury levels, with an associated chance for weaning of organ support and survival to discharge. The case further reminds us of intoxication as a cause of multiorgan dysfunction. We propose to immediately initiate combined parenteral and enteral detoxification in cases of methyl mercury intoxication, especially in cases of high doses.

Published
2019
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39. Safety and Specimen Adequacy of Ambulant Renal Transplant Biopsies.

Author

Schwarz, A., Gwinner, W., Hiss, M., Radermacher, J., Eisenberger, U., Mengel, M., and Haller, H.

Subjects
KIDNEY transplantation, CLINICAL pathology, BIOPSY, BLOOD transfusion reaction, HEMORRHAGE, BLOOD transfusion, URINALYSIS
Abstract

Objective: In order to establish a protocol biopsy program after renal transplantation, we started to perform renal transplant biopsies on a day-care basis in October of 2000. Since then, we performed 1,470 ambulant biopsies on 796 patients. Methods: Biopsies were done using an 18-gauge automated biopsy needle (since October 2003 16 gauge) followed by 4 hours bed rest in hospital with blood pressure and urine control as well as an ultrasound before and after biopsy, keeping the patient in hospital in cases of complication or rejection. Results: 1,039 protocol biopsies were performed in 444 renal transplant patients (1st biopsy after 6 weeks, n = 356, 2nd biopsy after 12 weeks, n = 358, 3rd biopsy after 6 months, n = 325); as well as 431 biopsies on indication in 384 patients (creatinine increase or proteinuria). The following complications were observed: Gross hematuria n = 55 (3.7%); hospitalization 20, urinary catheter 12, blood transfusion 1; Perirenal hematoma (ultrasound) n = 31 (2%); hospitalization 7, blood transfusion 4; Vasovagal reaction n = 7 (0.5%); hospitalization 3; av-fistula (doppler sonography) n = 113 (7.7%); persistent 14, spontaneous resolution 46, without control 53. There was no statistically significant difference between complications in protocol biopsies and biopsies on indication (hematuria, 3.8 vs 3.5%; perirenal hematoma, 2.4 vs 1.4%; vasovagal reaction, 0.7 vs 0%; av-fistula, 7.8 vs 7.4%); and no significant difference using a 18 gauge (1,222 biopsies) or a 16 gauge needle (248 biopsies) (hematuria, 4 vs 4%; perirenal hematoma, 2 vs 3%; av-fistula, 8 vs 4%). According to the Banff criteria of specimen adequacy, all biopsies had sufficient cortical area for evaluation of interstitial fibrosis and tubular atrophy; however, evaluating one tissue core, 49.6% of biopsies showed <7 glomeruli and/or no arterial cross section (18 gauge needle). Specimen adequacy increased using a 16 gauge needle (only 19% <7 glomeruli and/or no arterial cross section). Conclusions: We conclude that outpatient renal transplant biopsies can be performed safely and allow for the establishment of a protocol biopsy program. To ameliorate specimen adequacy, we changed from 18 to 16 gauge biopsy needle. Relevant biopsy complications like gross hematuria or perirenal hematoma are usually noticed during the 4 hours of bed rest following the biopsy. Biopsyinduced av-fistula are frequent and are either resolved spontaneously or remain without clinical importance. [ABSTRACT FROM AUTHOR]

Published
2004

41. Post-operative evaluation of computed tomography imaging following cochlear implantation.

Author

Kaul VF, Brannan Z, Keith J, Hittle B, Riggs W, Hiss M, Varadarajan V, Zhan K, Powell K, Wiet GJ, and Adunka OF

Subjects
Adult, Humans, Retrospective Studies, Cochlea diagnostic imaging, Cochlea surgery, Tomography, X-Ray Computed, Cochlear Implantation methods, Cochlear Implants, Speech Perception
Abstract

Purpose: This study utilized an automated segmentation algorithm to assess the cochlear implant electrode array within the cochlea and investigate its impact on audiologic outcomes as measured by post-operative speech perception scores. Furthermore, manual evaluations of electrode placement were compared to automatic segmentation methods to determine their accuracy in predicting post-operative audiologic outcomes., Materials and Methods: This retrospective chart review was conducted at a tertiary care referral center involving adult post-lingually deafened cochlear implant recipients implanted from 2015 to 2019. Patients with appropriate postoperative imaging and speech testing were included. Patients were excluded if non-English speaking, had a cognitive deficit, or a labyrinthine malformation. Automated and manual methods were used to analyze computed tomography (CT) scans and correlate the findings with post-operative speech perception scores and detection of electrode translocation., Results: Among the 47 patients who met inclusion criteria, 15 had electrode translocations confirmed by automatic segmentation methods. Controlling for CI usage and pre-operative AzBio scores, patients with translocation exhibited significantly lower consonant-nucleus consonant (CNC) and AzBio scores at 6-months post-implantation compared to patients with ST insertions. Moreover, the number of translocated electrode contacts was significantly associated with post-operative CNC scores. Manual evaluations of electrode location were predictive but less sensitive to electrode translocations when compared with automated 3D segmentation., Conclusions: Placement of CI electrode contacts within ST without translocation into SV, leads to improved audiologic outcomes. Manual assessment of electrode placement via temporal bone CT, without 3D reconstruction, provides a less sensitive method to determine electrode placement than automated methods., Level of Evidence: Level 4., Lay Summary: This study investigated the impact of electrode placement on speech outcomes for cochlear implant recipients. Using advanced imaging techniques, the researchers compared automated and manual methods for evaluating electrode position and examined the relationship between electrode translocation and audiologic outcomes. The findings revealed that proper placement within the cochlea without translocation into inappropriate compartments inside the cochlea improves speech understanding. Manual evaluations were somewhat accurate but less sensitive in detecting translocations compared to automated methods, which offer more precise predictions of patient outcomes. These results contribute to our understanding of factors influencing cochlear implant success and highlight the importance of optimizing electrode placement for improved speech outcomes., Competing Interests: Declaration of competing interest Oliver Adunka No other authors have any conflicts of interest., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Published
2024
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42. Mycophenolate mofetil in giant cell arteritis.

Author

Pankow A, Sinno S, Derlin T, Hiss M, and Wagner AD

Abstract

Introduction: Giant cell arteritis (GCA) is a systemic granulomatous vasculitis affecting the large arteries. Abnormal lymphocyte function has been noted as a pathogenic factor in GCA. Mycophenolate mofetil (MMF) inhibits inosine monophosphate dehydrogenase and is therefore a highly lymphocyte-specific immunosuppressive therapy. We aimed to assess the efficacy of MMF for inducing remission in GCA., Methods: Seven patients (5 female, 2 male) with GCA under therapy with MMF and who were treated at the outpatient clinic for rare inflammatory systemic diseases at Hannover Medical School between 2010 and 2023 were retrospectively included in the study. All patients underwent duplex sonography, 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET), magnetic resonance imaging (MRI), and/or biopsy to confirm the diagnosis. The primary endpoints were the number of recurrences, CRP levels at 3-6 and 6-12 months, and the period of remission., Results: All patients in this case series showed inflammatory activity of the arterial vessels in at least one of the imaging modalities: duplex sonography ( n  = 5), 18 F-FDG PET ( n  = 5), MRI ( n  = 6), and/or biopsy ( n  = 5). CRP levels of all patients decreased at the measurement time points 3-6 months, and 6-9 months after initiation of therapy with MMF compared with CRP levels before MMF therapy. All patients with GCA in this case series achieved disease remission., Discussion: The results of the present case series indicate that MMF is an effective therapy in controlling disease activity in GCA, which should be investigated in future randomized controlled trials., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Pankow, Sinno, Derlin, Hiss and Wagner.)

Published
2023
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43. JGI Plant Gene Atlas: an updateable transcriptome resource to improve functional gene descriptions across the plant kingdom.

Author

Sreedasyam A, Plott C, Hossain MS, Lovell JT, Grimwood J, Jenkins JW, Daum C, Barry K, Carlson J, Shu S, Phillips J, Amirebrahimi M, Zane M, Wang M, Goodstein D, Haas FB, Hiss M, Perroud PF, Jawdy SS, Yang Y, Hu R, Johnson J, Kropat J, Gallaher SD, Lipzen A, Shakirov EV, Weng X, Torres-Jerez I, Weers B, Conde D, Pappas MR, Liu L, Muchlinski A, Jiang H, Shyu C, Huang P, Sebastian J, Laiben C, Medlin A, Carey S, Carrell AA, Chen JG, Perales M, Swaminathan K, Allona I, Grattapaglia D, Cooper EA, Tholl D, Vogel JP, Weston DJ, Yang X, Brutnell TP, Kellogg EA, Baxter I, Udvardi M, Tang Y, Mockler TC, Juenger TE, Mullet J, Rensing SA, Tuskan GA, Merchant SS, Stacey G, and Schmutz J

Subjects
Gene Expression Regulation, Plant, Genome, Plant, Phylogeny, Software, Atlases as Topic, Genes, Plant, Transcriptome genetics
Abstract

Gene functional descriptions offer a crucial line of evidence for candidate genes underlying trait variation. Conversely, plant responses to environmental cues represent important resources to decipher gene function and subsequently provide molecular targets for plant improvement through gene editing. However, biological roles of large proportions of genes across the plant phylogeny are poorly annotated. Here we describe the Joint Genome Institute (JGI) Plant Gene Atlas, an updateable data resource consisting of transcript abundance assays spanning 18 diverse species. To integrate across these diverse genotypes, we analyzed expression profiles, built gene clusters that exhibited tissue/condition specific expression, and tested for transcriptional response to environmental queues. We discovered extensive phylogenetically constrained and condition-specific expression profiles for genes without any previously documented functional annotation. Such conserved expression patterns and tightly co-expressed gene clusters let us assign expression derived additional biological information to 64 495 genes with otherwise unknown functions. The ever-expanding Gene Atlas resource is available at JGI Plant Gene Atlas (https://plantgeneatlas.jgi.doe.gov) and Phytozome (https://phytozome.jgi.doe.gov/), providing bulk access to data and user-specified queries of gene sets. Combined, these web interfaces let users access differentially expressed genes, track orthologs across the Gene Atlas plants, graphically represent co-expressed genes, and visualize gene ontology and pathway enrichments., (© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.)

Published
2023
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44. First-in-Man Use of the Percutaneous 10F Reitan Catheter Pump for Cardiorenal Syndrome.

Author

Napp LC, Mariani S, Ruhparwar A, Schmack B, Keeble TR, Reitan O, Hanke JS, Dogan G, Hiss M, Bauersachs J, Haverich A, and Schmitto JD

Subjects
Catheters, Hemodynamics, Humans, Kidney, Cardio-Renal Syndrome complications, Cardio-Renal Syndrome therapy, Heart Failure complications, Heart Failure surgery
Abstract

Cardiorenal syndrome worsens outcome in patients with decompensated chronic heart failure, and complicates recompensation by medical therapy. Mechanical circulatory support has the potential to improve renal function, and likely mitigates diuretic resistance in patients with severe cardiorenal syndrome. The Reitan catheter pump (RCP) is a novel temporary percutaneous circulatory support system for reducing cardiac afterload and increasing renal preload. Here, we report on the first-in-man use of the 10F-version of the RCP device, which was associated with favorable effects on hemodynamics and diuresis. Further investigation to evaluate safety and efficacy of this promising approach is warranted., (Copyright © ASAIO 2021.)

Published
2022
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45. [Treatment-refractory anaemia in a 35-year-old heart transplant recipient on chronic hemodialysis].

Author

Schröder C, Roeles J, Schwarzer A, Heuser M, Retzlaff J, and Hiß M

Subjects
Adult, Humans, Immunoglobulins, Intravenous, Renal Dialysis adverse effects, Anemia, Refractory, Heart Transplantation adverse effects, Parvoviridae Infections diagnosis, Parvoviridae Infections therapy, Parvovirus B19, Human
Abstract

This article presents a case of pure red cell aplasia in a 35-year-old heart transplant recipient on chronic hemodialysis. Elevated parvovirus B19 immunoglobulin M blood levels were detected along with a high viral load of 80 billion IU/ml quantified by polymerase chain reaction. Bone marrow examination revealed giant proerythroblasts confirming parvovirus B19 infection. High-dose intravenous immunoglobulin was used for treatment. Anaemia had significantly improved 4 weeks later. Parvovirus B19 infection should be excluded in organ transplant recipients with anaemia due to ineffective erythropoiesis.

Published
2021
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46. Peritoneal dialysate-range hypertonic glucose promotes T-cell IL-17 production that induces mesothelial inflammation.

Author

Helmke A, Hüsing AM, Gaedcke S, Brauns N, Balzer MS, Reinhardt M, Hiss M, Shushakova N, de Luca D, Prinz I, Haller H, and von Vietinghoff S

Subjects
Animals, Cells, Cultured, Chemokine CCL2 immunology, Chemokine CXCL1 immunology, Female, Humans, Interleukin-6 immunology, Male, Mannose immunology, Mice, Mice, Inbred C57BL, Middle Aged, Mitochondria immunology, Peritoneal Dialysis methods, Reactive Oxygen Species immunology, Up-Regulation immunology, Epithelium immunology, Glucose immunology, Inflammation immunology, Interleukin-17 immunology, Peritoneum immunology, Th17 Cells immunology
Abstract

Peritoneal dialysis (PD) employs hypertonic glucose to remove excess water and uremic waste. Peritoneal membrane failure limits its long-term use. T-cell cytokines promote this decline. T-cell differentiation is critically determined by the microenvironment. We here study how PD-range hypertonic glucose regulates T-cell polarization and IL-17 production. In the human peritoneal cavity, CD3 + cell numbers increased in PD. Single cell RNA sequencing detected expression of T helper (Th) 17 signature genes RORC and IL23R. In vitro, PD-range glucose stimulated spontaneous and amplified cytokine-induced Th17 polarization. Osmotic controls l-glucose and d-mannose demonstrate that induction of IL-17A is a substance-independent, tonicity dose-dependent process. PD-range glucose upregulated glycolysis and increased the proportion of dysfunctional mitochondria. Blockade of reactive-oxygen species (ROS) prevented IL-17A induction in response to PD-range glucose. Peritoneal mesothelium cultured with IL-17A or IL17F produced pro-inflammatory cytokines IL-6, CCL2, and CX3CL1. In PD patients, peritoneal IL-17A positively correlated with CX3CL1 concentrations. PD-range glucose-stimulated, but neither identically treated Il17a -/- Il17f -/- nor T cells cultured with the ROS scavenger N-acetylcysteine enhanced mesothelial CX3CL1 expression. Our data delineate PD-range hypertonic glucose as a novel inducer of Th17 polarization in a mitochondrial-ROS-dependent manner. Modulation of tonicity-mediated effects of PD solutions may improve membrane survival., (© 2020 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.)

Published
2021
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47. Soluble neprilysin, NT-proBNP, and growth differentiation factor-15 as biomarkers for heart failure in dialysis patients (SONGBIRD).

Author

Claus R, Berliner D, Bavendiek U, Vodovar N, Lichtinghagen R, David S, Patecki M, Launay JM, Bauersachs J, Haller H, Hiss M, and Balzer MS

Subjects
Biomarkers blood, Female, Follow-Up Studies, Heart Failure etiology, Heart Failure physiopathology, Heart Failure therapy, Humans, Kidney Failure, Chronic complications, Kidney Failure, Chronic therapy, Male, Middle Aged, Predictive Value of Tests, Prognosis, Protein Precursors, ROC Curve, Retrospective Studies, Stroke Volume physiology, Growth Differentiation Factor 15 blood, Heart Failure blood, Natriuretic Peptide, Brain blood, Neprilysin blood, Peptide Fragments blood, Renal Dialysis adverse effects
Abstract

Background: Dialysis patients are at increased risk of HF. However, diagnostic utility of NT-proBNP as a biomarker is decreased in patients on dialysis. GDF-15 and cNEP are biomarkers of distinct mechanisms that may contribute to HF pathophysiology in such cohorts. The aim of this study was to determine whether growth differentiation factor-15 (GDF-15) and circulating neprilysin (cNEP) improve the diagnosis of congestive heart failure (HF) in patients on dialysis., Methods and Results: We compared circulating concentrations of NT-proBNP, GDF-15, and cNEP along with cNEP activity in patients on chronic dialysis without (n = 80) and with HF (n = 73), as diagnosed by clinical parameters and post-dialysis echocardiography. We used correlation, linear and logistic regression as well as receiver operating characteristic (ROC) analyses. Compared to controls, patients with HF had higher median values of NT-proBNP (16,216 [interquartile range, IQR = 27739] vs. 2883 [5866] pg/mL, p < 0.001), GDF-15 (7512 [7084] vs. 6005 [4892] pg/mL, p = 0.014), but not cNEP (315 [107] vs. 318 [124] pg/mL, p = 0.818). Median cNEP activity was significantly lower in HF vs. controls (0.189 [0.223] vs. 0.257 [0.166] nmol/mL/min, p < 0.001). In ROC analyses, a multi-marker model combining clinical covariates, NT-proBNP, GDF-15, and cNEP activity demonstrated best discrimination of HF from controls (AUC = 0.902, 95% CI 0.857-0.947, p < 0.001 vs. base model AUC = 0.785)., Conclusion: We present novel comparative data on physiologically distinct circulating biomarkers for HF in patients on dialysis. cNEP activity but not concentration and GDF-15 provided incremental diagnostic information over clinical covariates and NT-proBNP and may aid in diagnosing HF in dialysis patients.

Published
2020
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48. PEATmoss (Physcomitrella Expression Atlas Tool): a unified gene expression atlas for the model plant Physcomitrella patens.

Author

Fernandez-Pozo N, Haas FB, Meyberg R, Ullrich KK, Hiss M, Perroud PF, Hanke S, Kratz V, Powell AF, Vesty EF, Daum CG, Zane M, Lipzen A, Sreedasyam A, Grimwood J, Coates JC, Barry K, Schmutz J, Mueller LA, and Rensing SA

Subjects
Atlases as Topic, Bryopsida metabolism, Datasets as Topic, Gene Expression genetics, Genes, Plant genetics, Internet, Mycorrhizae metabolism, Bryopsida genetics, Transcriptome genetics
Abstract

Physcomitrella patens is a bryophyte model plant that is often used to study plant evolution and development. Its resources are of great importance for comparative genomics and evo-devo approaches. However, expression data from Physcomitrella patens were so far generated using different gene annotation versions and three different platforms: CombiMatrix and NimbleGen expression microarrays and RNA sequencing. The currently available P. patens expression data are distributed across three tools with different visualization methods to access the data. Here, we introduce an interactive expression atlas, Physcomitrella Expression Atlas Tool (PEATmoss), that unifies publicly available expression data for P. patens and provides multiple visualization methods to query the data in a single web-based tool. Moreover, PEATmoss includes 35 expression experiments not previously available in any other expression atlas. To facilitate gene expression queries across different gene annotation versions, and to access P. patens annotations and related resources, a lookup database and web tool linked to PEATmoss was implemented. PEATmoss can be accessed at https://peatmoss.online.uni-marburg.de., (© 2019 The Authors. The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.)

Published
2020
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49. Patient Perspectives on Renal Replacement Therapy Modality Choice: A Multicenter Questionnaire Study on Bioethical Dimensions.

Author

Balzer MS, Clajus C, Eden G, Euteneuer F, Haller HG, Martin H, Patecki M, Schmitt R, Hiss M, and Fuerholzer K

Subjects
Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Kidney Failure, Chronic economics, Male, Middle Aged, Renal Replacement Therapy economics, Socioeconomic Factors, Young Adult, Bioethical Issues, Cost of Illness, Kidney Failure, Chronic therapy, Personal Autonomy, Renal Replacement Therapy methods, Surveys and Questionnaires
Abstract

Background: Peritoneal dialysis (PD) incidence and prevalence in Germany are low compared with hemodialysis (HD), an underachievement with multifactorial causes. Patient perspectives on renal replacement therapy (RRT) choice play a growing role in research. To date, and to the best of our knowledge, the importance of bioethical dimensions in the context of RRT choice has not been analyzed. The aim of this multicenter questionnaire study was to delineate differences in patient perspectives of PD vs HD in terms of bioethical dimensions, thus helping nephrologists target potential PD candidates more efficiently. Methods: A total of 121 stable outpatients from 2 tertiary care hospitals and 4 dialysis clinics were surveyed for bioethical dimensions ("autonomy," "beneficence," "non-maleficence," "justice," and "trust") with ranking and Likert scale items. Inclusion criteria were RRT > 3 months, age ≥ 18 years, and sufficient cognitive and language skills. Results: A surprisingly high percentage of patients felt excluded from the RRT choice process. Peritoneal dialysis patients were more critical of RRT. They used more versatile information sources on RRT, whereas HD patients were mainly informed by their nephrologist. Peritoneal dialysis patients felt more often dissatisfied with RRT than HD patients and had less trust in their co-patients. However, PD patients felt less autonomy impairment regarding body integrity, fluid balance, and dialysis in general. Conclusions: Our study demonstrates that PD patients showed more scrutiny of their situation as patients, especially their co-patients. Their treatment empowered them toward feeling more autonomous than HD patients. These new insights into patient perspectives on RRT choice might facilitate modality choice for nephrologists., (Copyright © 2019 International Society for Peritoneal Dialysis.)

Published
2019
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50. Protein kinase C beta deficiency increases glucose-mediated peritoneal damage via M1 macrophage polarization and up-regulation of mesothelial protein kinase C alpha.

Author

Balzer MS, Helmke A, Ackermann M, Casper J, Dong L, Hiss M, Kiyan Y, Rong S, Timrott K, von Vietinghoff S, Wang L, Haller H, and Shushakova N

Subjects
Animals, Chemokine CCL2 metabolism, Dialysis Solutions metabolism, Disease Models, Animal, Epithelial Cells, Epithelium, Female, Glucose metabolism, Humans, Inflammation, Lipopolysaccharides pharmacology, Mice, Mice, Transgenic, Neovascularization, Pathologic, Omentum metabolism, Peritoneal Fibrosis metabolism, Peritoneum metabolism, Protein Isoforms, Protein Kinase C-alpha metabolism, Tumor Necrosis Factor-alpha metabolism, Up-Regulation, Macrophages metabolism, Peritoneal Dialysis adverse effects, Protein Kinase C beta deficiency
Abstract

Background: Peritoneal membrane (PM) damage during peritoneal dialysis (PD) is mediated largely by high glucose (HG)-induced pro-inflammatory and neo-angiogenic processes, resulting in PM fibrosis and ultrafiltration failure. We recently demonstrated a crucial role for protein kinase C (PKC) isoform α in mesothelial cells., Methods: In this study we investigate the role of PKCβ in PM damage in vitro using primary mouse peritoneal macrophages (MPMΦ), human macrophages (HMΦ) and immortalized mouse peritoneal mesothelial cells (MPMCs), as well as in vivo using a chronic PD mouse model., Results: We demonstrate that PKCβ is the predominant classical PKC isoform expressed in primary MPMΦ and its expression is up-regulated in vitro under HG conditions. After in vitro lipopolysaccharides stimulation PKCβ-/- MPMΦ demonstrates increased levels of interleukin 6 (IL-6), tumour necrosis factor α, and monocyte chemoattractant protein-1 and drastically decrease IL-10 release compared with wild-type (WT) cells. In vivo, catheter-delivered treatment with HG PD fluid for 5 weeks induces PKCβ up-regulation in omentum of WT mice and results in inflammatory response and PM damage characterized by fibrosis and neo-angiogenesis. In comparison to WT mice, all pathological changes are strongly aggravated in PKCβ-/- animals. Underlying molecular mechanisms involve a pro-inflammatory M1 polarization shift of MPMΦ and up-regulation of PKCα in MPMCs of PKCβ-/- mice. Finally, we demonstrate PKCβ involvement in HG-induced polarization processes in HMΦ., Conclusions: PKCβ as the dominant PKC isoform in MPMΦ is up-regulated by HG PD fluid and exerts anti-inflammatory effects during PD through regulation of MPMΦ M1/M2 polarization and control of the dominant mesothelial PKC isoform α., (© The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.)

Published
2019
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