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2. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian

Published
2022
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3. Inflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study

Author

Fontvieille, Emma, His, Mathilde, Biessy, Carine, Navionis, Anne-Sophie, Torres-Mejía, Gabriela, Ángeles-Llerenas, Angélica, Alvarado-Cabrero, Isabel, Sánchez, Gloria Inés, Navarro, Edgar, Cortes, Yorlany Rodas, Porras, Carolina, Rodriguez, Ana Cecilia, Garmendia, Maria Luisa, Soto, José Luis, Moyano, Leonor, Porter, Peggy L., Lin, Ming Gang, Guenthoer, Jamie, Romieu, Isabelle, and Rinaldi, Sabina

Published
2022
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4. Multi-trait body shape phenotypes and breast cancer risk in postmenopausal women: a causal mediation analysis in the UK Biobank cohort

Author

Amadou, Amina, primary, Freisling, Heinz, additional, Sedlmeier, Anja M., additional, Bohmann, Patricia, additional, Fontvieille, Emma, additional, Weber, Andrea, additional, Konzok, Julian, additional, Stein, Michael J, additional, Peruchet-Noray, Laia, additional, Jansana, Anna, additional, Noh, Hwayoung, additional, His, Mathilde, additional, Gan, Quan, additional, Baurecht, Hansjörg, additional, and Fervers, Béatrice, additional

Published
2024
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6. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Author

Duarte-Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno-de-Mesquita, HB As, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Quirós, J Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay-Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, and Jenab, Mazda

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Hepatitis, Infectious Diseases, Hepatitis - B, Liver Cancer, Prevention, Liver Disease, Cancer, Chronic Liver Disease and Cirrhosis, Rare Diseases, Nutrition, Digestive Diseases, Clinical Research, Emerging Infectious Diseases, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Good Health and Well Being, Adult, Aged, Carcinoma, Hepatocellular, Case-Control Studies, Diet, Dietary Fats, Europe, Feeding Behavior, Female, Humans, Incidence, Life Style, Liver Neoplasms, Male, Middle Aged, Nutritional Status, Prospective Studies, Risk, Risk Factors, Surveys and Questionnaires, Young Adult, European populations, cohort study, dietary fats, hepatocellular carcinoma, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.

Published
2015

7. Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort

Author

His, Mathilde, Viallon, Vivian, Dossus, Laure, Schmidt, Julie A., Travis, Ruth C., Gunter, Marc J., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Lécuyer, Lucie, Rothwell, Joseph A., Severi, Gianluca, Johnson, Theron, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Macciotta, Alessandra, Boer, Jolanda M. A., Monninkhof, Evelyn M., Olsen, Karina Standahl, Nøst, Therese H., Sandanger, Torkjel M., Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Ardanaz, Eva, Vidman, Linda, Winkvist, Anna, Heath, Alicia K., Weiderpass, Elisabete, Huybrechts, Inge, and Rinaldi, Sabina

Published
2021
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12. Nutrient-wide association study of 92 foods and nutrients and breast cancer risk

Author

Heath, Alicia K., Muller, David C., van den Brandt, Piet A., Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B., Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F., van Gils, Carla H., Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K., and Tzoulaki, Ioanna

Published
2020
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14. Key takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): a report from the TREC Training Workshop 2022

Author

Kung, Che-Pei, primary, Skiba, Meghan B, additional, Crosby, Erika J, additional, Gorzelitz, Jessica, additional, Kennedy, Mary A, additional, Kerr, Bethany A, additional, Li, Yun Rose, additional, Nash, Sarah, additional, Potiaumpai, Melanie, additional, Kleckner, Amber S, additional, James, Dara L, additional, Coleman, Michael F, additional, Fairman, Ciaran M, additional, Galván, Gloria C, additional, Garcia, David O, additional, Gordon, Max J, additional, His, Mathilde, additional, Hornbuckle, Lyndsey M, additional, Kim, So-Youn, additional, Kim, Tae-Hyung, additional, Kumar, Amanika, additional, Mahé, Mélanie, additional, McDonnell, Karen K, additional, Moore, Jade, additional, Oh, Sangphil, additional, Sun, Xinghui, additional, and Irwin, Melinda L, additional

Published
2023
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15. Data from Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort

Author

Sarink, Danja, primary, Schock, Helena, primary, Johnson, Theron, primary, Overvad, Kim, primary, Holm, Marianne, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, His, Mathilde, primary, Kvaskoff, Marina, primary, Boeing, Heiner, primary, Lagiou, Pagona, primary, Papatesta, Eleni-Maria, primary, Trichopoulou, Antonia, primary, Palli, Domenico, primary, Pala, Valeria, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Bueno-de-Mesquita, H.B(as)., primary, van Gils, Carla H., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Agudo, Antonio, primary, Sánchez, Maria-José, primary, Chirlaque, Maria-Dolores, primary, Ardanaz, Eva, primary, Amiano, Pilar, primary, Khaw, Kay Tee, primary, Travis, Ruth, primary, Dossus, Laure, primary, Gunter, Mark, primary, Rinaldi, Sabina, primary, Merritt, Melissa, primary, Riboli, Elio, primary, Kaaks, Rudolf, primary, and Fortner, Renée T., primary

Published
2023
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16. Supplementary Tables 1-6 from Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort

Author

Sarink, Danja, primary, Schock, Helena, primary, Johnson, Theron, primary, Overvad, Kim, primary, Holm, Marianne, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, His, Mathilde, primary, Kvaskoff, Marina, primary, Boeing, Heiner, primary, Lagiou, Pagona, primary, Papatesta, Eleni-Maria, primary, Trichopoulou, Antonia, primary, Palli, Domenico, primary, Pala, Valeria, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Bueno-de-Mesquita, H.B(as)., primary, van Gils, Carla H., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Agudo, Antonio, primary, Sánchez, Maria-José, primary, Chirlaque, Maria-Dolores, primary, Ardanaz, Eva, primary, Amiano, Pilar, primary, Khaw, Kay Tee, primary, Travis, Ruth, primary, Dossus, Laure, primary, Gunter, Mark, primary, Rinaldi, Sabina, primary, Merritt, Melissa, primary, Riboli, Elio, primary, Kaaks, Rudolf, primary, and Fortner, Renée T., primary

Published
2023
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17. Key takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): A report from the TREC Training Workshop 2022

Author

Kung, Che Pei, Skiba, Meghan B., Crosby, Erika J., Gorzelitz, Jessica, Kennedy, Mary A., Kerr, Bethany A., Li, Yun Rose, Nash, Sarah, Potiaumpai, Melanie, Kleckner, Amber S., James, Dara L., Coleman, Michael F., Fairman, Ciaran M., Galván, Gloria C., Garcia, David O., Gordon, Max J., His, Mathilde, Hornbuckle, Lyndsey M., Kim, So Youn, Kim, Tae Hyung, Kumar, Amanika, Mahé, Mélanie, McDonnell, Karen K., Moore, Jade, Oh, Sangphil, Sun, Xinghui, Irwin, Melinda L., Kung, Che Pei, Skiba, Meghan B., Crosby, Erika J., Gorzelitz, Jessica, Kennedy, Mary A., Kerr, Bethany A., Li, Yun Rose, Nash, Sarah, Potiaumpai, Melanie, Kleckner, Amber S., James, Dara L., Coleman, Michael F., Fairman, Ciaran M., Galván, Gloria C., Garcia, David O., Gordon, Max J., His, Mathilde, Hornbuckle, Lyndsey M., Kim, So Youn, Kim, Tae Hyung, Kumar, Amanika, Mahé, Mélanie, McDonnell, Karen K., Moore, Jade, Oh, Sangphil, Sun, Xinghui, and Irwin, Melinda L.

Abstract

The overall goal of the annual Transdisciplinary Research in Energetics and Cancer (TREC) Training Workshop is to provide transdisciplinary training for scientists in energetics and cancer and clinical care. The 2022 Workshop included 27 early-to-mid career investigators (trainees) pursuing diverse TREC research areas in basic, clinical, and population sciences. The 2022 trainees participated in a gallery walk, an interactive qualitative program evaluation method, to summarize key takeaways related to program objectives. Writing groups were formed and collaborated on this summary of the 5 key takeaways from the TREC Workshop. The 2022 TREC Workshop provided a targeted and unique networking opportunity that facilitated meaningful collaborative work addressing research and clinical needs in energetics and cancer. This report summarizes the 2022 TREC Workshop's key takeaways and future directions for innovative transdisciplinary energetics and cancer research.

Published
2023

18. Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

Author

Merritt, Melissa A, Tzoulaki, Ioanna, van den Brandt, Piet A, Schouten, Leo J, Tsilidis, Konstantinos K, Weiderpass, Elisabete, Patel, Chirag J, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, His, Mathilde, Dartois, Laureen, Boutron-Ruault, Marie-Christine, Fortner, Renée T, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Mattiello, Amalia, Bueno-de-Mesquita, H Bas, Onland-Moret, N Charlotte, Peeters, Petra H, Skeie, Guri, Jareid, Mie, Quirós, J Ramón, Obón-Santacana, Mireia, Sánchez, María-José, Chamosa, Saioa, Huerta, José M, Barricarte, Aurelio, Dias, Joana A, Sonestedt, Emily, Idahl, Annika, Lundin, Eva, Wareham, Nicholas J, Khaw, Kay-Tee, Travis, Ruth C, Ferrari, Pietro, Riboli, Elio, and Gunter, Marc J

Published
2016
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19. Prospective analysis of circulating metabolites and breast cancer in EPIC

Author

His, Mathilde, Viallon, Vivian, Dossus, Laure, Gicquiau, Audrey, Achaintre, David, Scalbert, Augustin, Ferrari, Pietro, Romieu, Isabelle, Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Rothwell, Joseph A., Severi, Gianluca, Kühn, Tilman, Fortner, Renée T., Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, van Gils, Carla H., Nøst, Therese H., Sandanger, Torkjel M., Skeie, Guri, Quirós, J. Ramón, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José María, Ardanaz, Eva, Schmidt, Julie A., Travis, Ruth C., Riboli, Elio, Tsilidis, Konstantinos K., Christakoudi, Sofia, Gunter, Marc J., and Rinaldi, Sabina

Published
2019
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21. Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort

Author

Sarink, Danja, Schock, Helena, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Boeing, Heiner, Karakatsani, Anna, Trichopoulou, Antonia, La Vecchia, Carlo, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, van Gils, Carla H., Peeters, Petra H. M., Weiderpass, Elisabete, Agudo, Antonio, Rodríguez-Barranco, Miguel, Huerta, José María, Ardanaz, Eva, Gil, Leire, Kaw, Kay Tee, Schmidt, Julie A., Dossus, Laure, His, Mathilde, Aune, Dagfinn, Riboli, Elio, Kaaks, Rudolf, and Fortner, Renée T.

Published
2018
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22. Reproductive factors and molecular subtypes of breast cancer among premenopausal women in Latin America: the PRECAMA study

Author

Romieu, Isabelle, Biessy, Carine, Carayol, Marion, His, Mathilde, Torres-Mejía, Gabriela, Ángeles-Llerenas, Angélica, Sánchez, Gloria Inés, Jaramillo, Roberto, Navarro, Edgar, Porras, Carolina, Ocampo, Rebecca, Rodriguez, Ana Cecilia, Garmendia, Maria Luisa, Bustamante, Eva, Olivier, Magali, Porter, Peggy, Rinaldi, Sabina, and On behalf of the PRECAMA team

Published
2018
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23. Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer

Author

Grenville, Zoe S., primary, Noor, Urwah, additional, His, Mathilde, additional, Viallon, Vivian, additional, Rinaldi, Sabina, additional, Aglago, Elom K., additional, Amiano, Pilar, additional, Brunkwall, Louise, additional, Chirlaque, María Dolores, additional, Drake, Isabel, additional, Eichelmann, Fabian, additional, Freisling, Heinz, additional, Grioni, Sara, additional, Heath, Alicia K., additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Mayén-Chacon, Ana-Lucia, additional, Milani, Lorenzo, additional, Moreno-Iribas, Conchi, additional, Pala, Valeria, additional, Olsen, Anja, additional, Sánchez, Maria-Jose, additional, Schulze, Matthias B., additional, Tjønneland, Anne, additional, Tsilidis, Konstantinos K., additional, Weiderpass, Elisabete, additional, Winkvist, Anna, additional, Zamora-Ros, Raul, additional, Key, Timothy J., additional, Smith-Byrne, Karl, additional, Travis, Ruth C., additional, and Schmidt, Julie A., additional

Published
2022
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24. Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer

Author

Grenville, Zoe S., Noor, Urwah, His, Mathilde, Viallon, Vivian, Rinaldi, Sabina, Aglago, Elom K., Amiano, Pilar, Brunkwall, Louise, Chirlaque, María Dolores, Drake, Isabel, Eichelmann, Fabian, Freisling, Heinz, Grioni, Sara, Heath, Alicia K., Kaaks, Rudolf, Katzke, Verena, Mayén-Chacon, Ana-Lucia, Milani, Lorenzo, Moreno-Iribas, Conchi, Pala, Valeria, Olsen, Anja, Sánchez, Maria-Jose, Schulze, Matthias B., Tjønneland, Anne, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Winkvist, Anna, Zamora-Ros, Raul, Key, Timothy J., Smith-Byrne, Karl, Travis, Ruth C., Schmidt, Julie A., Grenville, Zoe S., Noor, Urwah, His, Mathilde, Viallon, Vivian, Rinaldi, Sabina, Aglago, Elom K., Amiano, Pilar, Brunkwall, Louise, Chirlaque, María Dolores, Drake, Isabel, Eichelmann, Fabian, Freisling, Heinz, Grioni, Sara, Heath, Alicia K., Kaaks, Rudolf, Katzke, Verena, Mayén-Chacon, Ana-Lucia, Milani, Lorenzo, Moreno-Iribas, Conchi, Pala, Valeria, Olsen, Anja, Sánchez, Maria-Jose, Schulze, Matthias B., Tjønneland, Anne, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Winkvist, Anna, Zamora-Ros, Raul, Key, Timothy J., Smith-Byrne, Karl, Travis, Ruth C., and Schmidt, Julie A.

Abstract

Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern 1), acylcarnitines C18:1 and C18:2, glutamate, ornithine, and taurine (Pattern 2), and 8 lysophosphatidylcholines (Pattern 3). In a two-stage cross-sectional discovery (n = 2524) and validation (n = 518) design containing 3042 men free of cancer in EPIC, we estimated the associations of 24 dietary and lifestyle variables with each pattern and the contributing individual metabolites. Associations statistically significant after both correction for multiple testing (False Discovery Rate = 0.05) in the discovery set and at p < 0.05 in the validation set were considered robust. Intakes of alcohol, total fish products, and its subsets total fish and lean fish were positively associated with Pattern 1. Body mass index (BMI) was positively associated with Pattern 2, which appeared to be driven by a strong positive BMI-glutamate association. Finally, both BMI and fatty fish were inversely associated with Pattern 3. In conclusion, these results indicate associations of fish and its subtypes, alcohol, and BMI with metabolite patterns that are inversely associated with risk of aggressive prostate cancer.

Published
2022
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25. Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Kyrø, Cecilie, Zamora-Ros, Raul, Scalbert, Augustin, Tjønneland, Anne, Dossus, Laure, Johansen, Christoffer, Bidstrup, Pernille Envold, Weiderpass, Elisabete, Christensen, Jane, Ward, Heather, Aune, Dagfinn, Riboli, Elio, His, Mathilde, Clavel-Chapelon, Françoise, Baglietto, Laura, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Floegel, Anna, Overvad, Kim, Lasheras, Cristina, Travier, Noémie, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nick, Perez-Cornago, Aurora, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Grioni, Sara, Berrino, Franco, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Bueno-de-Mesquita, H. B(as)., Peeters, Petra H., van Gils, Carla, Borgquist, Signe, Butt, Salma, Zeleniuch-Jacquotte, Anne, Sund, Malin, Hjartåker, Anette, Skeie, Guri, Olsen, Anja, and Romieu, Isabelle

Published
2015
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26. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, primary, Ferrari, Pietro, additional, Dossus, Laure, additional, Jenab, Mazda, additional, Johansson, Mattias, additional, Rinaldi, Sabina, additional, Travis, Ruth C., additional, His, Mathilde, additional, Key, Tim J., additional, Schmidt, Julie A., additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Rothwell, Joseph A., additional, Laouali, Nasser, additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Eichelmann, Fabian, additional, Palli, Domenico, additional, Grioni, Sara, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno-de-Mesquita, Bas, additional, Olsen, Karina Standahl, additional, Sandanger, Torkjel Manning, additional, Nøst, Therese Haugdahl, additional, Quirós, J. Ramón, additional, Bonet, Catalina, additional, Barranco, Miguel Rodríguez, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Sandsveden, Malte, additional, Manjer, Jonas, additional, Vidman, Linda, additional, Rentoft, Matilda, additional, Muller, David, additional, Tsilidis, Kostas, additional, Heath, Alicia K., additional, Keun, Hector, additional, Adamski, Jerzy, additional, Keski-Rahkonen, Pekka, additional, Scalbert, Augustin, additional, Gunter, Marc J., additional, and Viallon, Vivian, additional

Published
2022
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27. Additional file 1 of Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian

Abstract

Additional file 1. Supplementary material regarding (i) the definition of cancer cases for HCC, GBC, Adv.PrC and Loc.PrC; (ii) the definition and implementation of the data-shared lasso; (iii) the models used to derive point estimates and confidence intervals from the model selected by the data-shared lasso; and (iv) the univariate analysis conducted for comparison.

Published
2022
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28. Additional file 2 of Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian

Abstract

Additional file 2: Supplementary tables and figures. Figure S1. Pearson correlation between the 117 original metabolites. Figure S2. Sensitivity analyses of mutually adjusted ORs for the overall associations and cancer type-specific deviations. Figure S3. Sensitivity analysis of mutually adjusted ORs for the overall associations and cancer type-specific deviations with or without excluding hormone users. Figure S4. p-values of tests for departure from linearity and effect modification by BMI. Figure S5. ORs for the overall associations identified by the data-shared lasso with (i) the original model (ii) the extended type-specific model. Figure S6. Results from the univariate analyses. Figure S7. Comparison of the associations identified by the data-shared lasso when working with the 50 features (as in our main analysis) or with the original 117 metabolites. Figure S8. Pearson correlation between the 50 clusters. Figure S9. Pearson correlation between the 19 features related to at least one cancer site in our main analysis. Table S1. list of the 117 metabolites studied in the main analysis, and of the 16 additional metabolites studied when excluding the second colorectal study. Table S2. Robustness of the associations identified in the main analysis when including all the pairs from the prostate cancer study. Table S3. Other associations identified in a large proportion of bootstrap samples when including all the pairs from the prostate cancer study.

Published
2022
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29. Additional file 1 of Inflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study

Author

Fontvieille, Emma, His, Mathilde, Biessy, Carine, Navionis, Anne-Sophie, Torres-Mejía, Gabriela, Ángeles-Llerenas, Angélica, Alvarado-Cabrero, Isabel, Sánchez, Gloria Inés, Navarro, Edgar, Cortes, Yorlany Rodas, Porras, Carolina, Rodriguez, Ana Cecilia, Garmendia, Maria Luisa, Soto, José Luis, Moyano, Leonor, Porter, Peggy L., Lin, Ming Gang, Guenthoer, Jamie, Romieu, Isabelle, and Rinaldi, Sabina

Abstract

Additional file 1. Main characteristics of cases by hormone receptor status, and for triple-negative tumors (Supplementary Table 1). Associations between IL-6 and TNF-alpha and breast cancer risk allowing for non-linear effects (natural cubic splines) (Supplementary Figure 1); Abbreviations: BMI body mass index; ER Estrogen receptor; HER2 human epidermal growth factor receptor 2; IFN-γ interferon γ; IL-6 interleukin 6; IL-8 interleukin 8; IL-10 interleukin 10; OR odds ratio; PR progesterone receptor; SD standard deviation; TNF-α tumor necrosis factor α. (DOC 109 KB).

Published
2022
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30. Consumption of industrial processed foods and risk of premenopausal breast cancer among Latin American women: the PRECAMA study

Author

Romieu, Isabelle, primary, Khandpur, Neha, additional, Katsikari, Aikaterini, additional, Biessy, Carine, additional, Torres-Mejía, Gabriela, additional, Ángeles-Llerenas, Angélica, additional, Alvarado-Cabrero, Isabel, additional, Sánchez, Gloria Inés, additional, Maldonado, Maria Elena, additional, Porras, Carolina, additional, Rodriguez, Ana Cecilia, additional, Garmendia, Maria Luisa, additional, Chajés, Vèronique, additional, Aglago, Elom K, additional, Porter, Peggy L, additional, Lin, MingGang, additional, His, Mathilde, additional, Gunter, Marc J, additional, Huybrechts, Inge, additional, and Rinaldi, Sabina, additional

Published
2022
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31. A New Pipeline for the Normalization and Pooling of Metabolomics Data

Author

Viallon, Vivian, primary, His, Mathilde, additional, Rinaldi, Sabina, additional, Breeur, Marie, additional, Gicquiau, Audrey, additional, Hemon, Bertrand, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Rostgaard-Hansen, Agnetha Linn, additional, Rothwell, Joseph A., additional, Lecuyer, Lucie, additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Johnson, Theron, additional, Schulze, Matthias B., additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Verschuren, W. M. Monique, additional, Engelfriet, Peter, additional, Onland-Moret, Charlotte, additional, Vermeulen, Roel, additional, Nøst, Therese Haugdahl, additional, Urbarova, Ilona, additional, Zamora-Ros, Raul, additional, Rodriguez-Barranco, Miguel, additional, Amiano, Pilar, additional, Huerta, José Maria, additional, Ardanaz, Eva, additional, Melander, Olle, additional, Ottoson, Filip, additional, Vidman, Linda, additional, Rentoft, Matilda, additional, Schmidt, Julie A., additional, Travis, Ruth C., additional, Weiderpass, Elisabete, additional, Johansson, Mattias, additional, Dossus, Laure, additional, Jenab, Mazda, additional, Gunter, Marc J., additional, Lorenzo Bermejo, Justo, additional, Scherer, Dominique, additional, Salek, Reza M., additional, Keski-Rahkonen, Pekka, additional, and Ferrari, Pietro, additional

Published
2021
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32. Additional file 1 of Biomarkers of mammographic density in premenopausal women

Author

His, Mathilde, Lajous, Martin, Gómez-Flores-Ramos, Liliana, Monge, Adriana, Dossus, Laure, Viallon, Vivian, Gicquiau, Audrey, Biessy, Carine, Gunter, Marc J., and Rinaldi, Sabina

Abstract

Additional file 1: Supplementary tables describing the completeness of the metabolites measures and coefficients of variations (Supplementary Table 1) and geometric mean of metabolites concentrations (Supplementary Table 2); Supplementary figures showing correlations between metabolites adjusted for age, batch, and state (Supplementary Figure 1) and associations between metabolites and non-dense area (Supplementary Figure 2).

Published
2021
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33. A new pipeline for the normalization and pooling of metabolomics data

Author

Viallon, Vivian, His, Mathilde, Rinaldi, Sabina, Breeur, Marie, Gicquiau, Audrey, Hemon, Bertrand, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Rothwell, Joseph A., Lecuyer, Lucie, Severi, Gianluca, Kaaks, Rudolf, Johnson, Theron, Schulze, Matthias B., Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Monique Verschuren, W.M., Engelfriet, Peter, Onland-Moret, Charlotte, Vermeulen, Roel, Nøst, Therese Haugdahl, Urbarova, Ilona, Zamora-Ros, Raul, Rodriguez-Barranco, Miguel, Amiano, Pilar, Huerta, José Maria, Ardanaz, Eva, Melander, Olle, Ottoson, Filip, Vidman, Linda, Rentoft, Matilda, Schmidt, Julie A., Travis, Ruth C., Weiderpass, Elisabete, Johansson, Mattias, Dossus, Laure, Jenab, Mazda, Gunter, Marc J., Bermejo, Justo Lorenzo, Scherer, Dominique, Salek, Reza M., Keski-Rahkonen, Pekka, Ferrari, Pietro, Viallon, Vivian, His, Mathilde, Rinaldi, Sabina, Breeur, Marie, Gicquiau, Audrey, Hemon, Bertrand, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Rothwell, Joseph A., Lecuyer, Lucie, Severi, Gianluca, Kaaks, Rudolf, Johnson, Theron, Schulze, Matthias B., Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Monique Verschuren, W.M., Engelfriet, Peter, Onland-Moret, Charlotte, Vermeulen, Roel, Nøst, Therese Haugdahl, Urbarova, Ilona, Zamora-Ros, Raul, Rodriguez-Barranco, Miguel, Amiano, Pilar, Huerta, José Maria, Ardanaz, Eva, Melander, Olle, Ottoson, Filip, Vidman, Linda, Rentoft, Matilda, Schmidt, Julie A., Travis, Ruth C., Weiderpass, Elisabete, Johansson, Mattias, Dossus, Laure, Jenab, Mazda, Gunter, Marc J., Bermejo, Justo Lorenzo, Scherer, Dominique, Salek, Reza M., Keski-Rahkonen, Pekka, and Ferrari, Pietro

Abstract

Pooling metabolomics data across studies is often desirable to increase the statistical power of the analysis. However, this can raise methodological challenges as several preanalytical and analytical factors could introduce differences in measured concentrations and variability between datasets. Specifically, different studies may use variable sample types (e.g., serum versus plasma) collected, treated, and stored according to different protocols, and assayed in different laboratories using different instruments. To address these issues, a new pipeline was developed to normalize and pool metabolomics data through a set of sequential steps: (i) exclusions of the least informative observations and metabolites and removal of outliers; imputation of missing data; (ii) identification of the main sources of variability through principal component partial R-square (PC-PR2) analysis; (iii) application of linear mixed models to remove unwanted variability, including samples’ originating study and batch, and preserve biological variations while accounting for potential differences in the residual variances across studies. This pipeline was applied to targeted metabolomics data acquired using Biocrates AbsoluteIDQ kits in eight case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Comprehensive examination of metabolomics measurements indicated that the pipeline improved the comparability of data across the studies. Our pipeline can be adapted to normalize other molecular data, including biomarkers as well as proteomics data, and could be used for pooling molecular datasets, for example in international consortia, to limit biases introduced by inter-study variability. This versatility of the pipeline makes our work of potential interest to molecular epidemiologists., (This article belongs to the Special Issue Metabolomics Meets Epidemiology).

Published
2021
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34. A New Pipeline for the Normalization and Pooling of Metabolomics Data

Author

Public Health Practice, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Cardiovasculaire Epi Team 3, Planetary Health & Exposoom, Cancer, Viallon, Vivian, His, Mathilde, Rinaldi, Sabina, Breeur, Marie, Gicquiau, Audrey, Hemon, Bertrand, Overvad, Kim, Tjonneland, Anne, Rostgaard-Hansen, Agnetha Linn, Rothwell, Joseph A., Lecuyer, Lucie, Severi, Gianluca, Kaaks, Rudolf, Johnson, Theron, Schulze, Matthias B., Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Verschuren, W. M. Monique, Engelfriet, Peter, Onland-Moret, Charlotte, Vermeulen, Roel, Nost, Therese Haugdahl, Urbarova, Ilona, Zamora-Ros, Raul, Rodriguez-Barranco, Miguel, Amiano, Pilar, Huerta, Jose Maria, Ardanaz, Eva, Melander, Olle, Ottoson, Filip, Vidman, Linda, Rentoft, Matilda, Schmidt, Julie A., Travis, Ruth C., Weiderpass, Elisabete, Johansson, Mattias, Dossus, Laure, Jenab, Mazda, Gunter, Marc J., Bermejo, Justo Lorenzo, Scherer, Dominique, Salek, Reza M., Keski-Rahkonen, Pekka, Ferrari, Pietro, Public Health Practice, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Cardiovasculaire Epi Team 3, Planetary Health & Exposoom, Cancer, Viallon, Vivian, His, Mathilde, Rinaldi, Sabina, Breeur, Marie, Gicquiau, Audrey, Hemon, Bertrand, Overvad, Kim, Tjonneland, Anne, Rostgaard-Hansen, Agnetha Linn, Rothwell, Joseph A., Lecuyer, Lucie, Severi, Gianluca, Kaaks, Rudolf, Johnson, Theron, Schulze, Matthias B., Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Verschuren, W. M. Monique, Engelfriet, Peter, Onland-Moret, Charlotte, Vermeulen, Roel, Nost, Therese Haugdahl, Urbarova, Ilona, Zamora-Ros, Raul, Rodriguez-Barranco, Miguel, Amiano, Pilar, Huerta, Jose Maria, Ardanaz, Eva, Melander, Olle, Ottoson, Filip, Vidman, Linda, Rentoft, Matilda, Schmidt, Julie A., Travis, Ruth C., Weiderpass, Elisabete, Johansson, Mattias, Dossus, Laure, Jenab, Mazda, Gunter, Marc J., Bermejo, Justo Lorenzo, Scherer, Dominique, Salek, Reza M., Keski-Rahkonen, Pekka, and Ferrari, Pietro

Published
2021

36. Nutrient-wide association study of 92 foods and nutrients and breast cancer risk

Author

Heath, Alicia K, Muller, David C., van den Brandt, Piet A., Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B., Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F., van Gils, Carla H., Standahl Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K., Tzoulaki, Ioanna, Heath, Alicia K, Muller, David C., van den Brandt, Piet A., Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B., Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F., van Gils, Carla H., Standahl Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K., and Tzoulaki, Ioanna

Abstract

BACKGROUND: Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. METHODS: Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). RESULTS: Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03-1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03-1.06 and 1.04, 95% CI 1.02-1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94-0.98; 0.96, 95% CI 0.94-0.99; and 0.96, 95% CI 0.95-0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. CONCLUSIONS: Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.

Published
2020
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37. Nutrient-wide association study of 92 foods and nutrients and breast cancer risk

Author

MS MDL 1, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Heath, Alicia K, Muller, David C, van den Brandt, Piet A, Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B, Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F, van Gils, Carla H, Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K, Tzoulaki, Ioanna, MS MDL 1, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Heath, Alicia K, Muller, David C, van den Brandt, Piet A, Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B, Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F, van Gils, Carla H, Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K, and Tzoulaki, Ioanna

Published
2020

40. Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: Results from the EPIC cohort

Author

Epi Methoden Team 4, Cancer, JC onderzoeksprogramma Kanker, Sarink, Danja, Schock, Helena, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Boeing, Heiner, Karakatsani, Anna, Trichopoulou, Antonia, La Vecchia, Carlo, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Van Gils, Carla H., Peeters, Petra H.M., Weiderpass, Elisabete, Agudo, Antonio, Rodríguez-Barranco, Miguel, Huerta, José María, Ardanaz, Eva, Gil, Leire, Kaw, Kay Tee, Schmidt, Julie A., Dossus, Laure, His, Mathilde, Aune, Dagfinn, Riboli, Elio, Kaaks, Rudolf, Fortner, Renée T., Epi Methoden Team 4, Cancer, JC onderzoeksprogramma Kanker, Sarink, Danja, Schock, Helena, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Boeing, Heiner, Karakatsani, Anna, Trichopoulou, Antonia, La Vecchia, Carlo, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Van Gils, Carla H., Peeters, Petra H.M., Weiderpass, Elisabete, Agudo, Antonio, Rodríguez-Barranco, Miguel, Huerta, José María, Ardanaz, Eva, Gil, Leire, Kaw, Kay Tee, Schmidt, Julie A., Dossus, Laure, His, Mathilde, Aune, Dagfinn, Riboli, Elio, Kaaks, Rudolf, and Fortner, Renée T.

Published
2018

41. Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Molina-Montes, Esther Sanchez, Maria-Jose Buckland, Genevieve and Bueno-de-Mesquita, H. B(as) Weiderpass, Elisabete Amiano, Pilar Wark, Petra A. Kuehn, Tilman Katzke, Verena Maria Huerta, Jose Ardanaz, Eva Ramon Quiros, Jose Affret, Aurelie and His, Mathilde Boutron-Ruault, Marie-Christine Peeters, Petra H. Ye, Weimin Sund, Malin Boeing, Heiner Iqbal, Khalid and Ohlsson, Bodil Sonestedt, Emily Tjonneland, Anne and Petersen, Kristina E. N. Travis, Ruth C. Skeie, Guri Agnoli, Claudia Panico, Salvatore Palli, Domenico Tumino, Rosario and Sacerdote, Carlotta Freisling, Heinz Huybrechts, Inge and Overvad, Kim Trichopoulou, Antonia Bamia, Christina and Vasilopoulou, Effie Wareham, Nick Khaw, Kay-Tee Cross, Amanda J. Ward, Heather A. Riboli, Elio Duell, Eric J.

Abstract

Background: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs). Results: Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence = 0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED = 1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern. Conclusions: A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.

Published
2017

42. Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort

Author

Fortner, Renee T. Sarink, Danja Schock, Helena Johnson, Theron Tjonneland, Anne Olsen, Anja Overvad, Kim Affret, Aurelie His, Mathilde Boutron-Ruault, Marie-Christine and Boeing, Heiner Trichopoulou, Antonia Naska, Androniki and Orfanos, Philippos Palli, Domenico Sieri, Sabina Mattiello, Amalia Tumino, Rosario Ricceri, Fulvio Bueno-de-Mesquita, H. Bas Peeters, Petra H. M. Van Gils, Carla H. Weiderpass, Elisabete Lund, Eiliv Quiros, J. Ramon Agudo, Antonio and Sanchez, Maria-Jose Chirlaque, Maria-Dolores Ardanaz, Eva and Dorronsoro, Miren Key, Tim Khaw, Kay-Tee Rinaldi, Sabina and Dossus, Laure Gunter, Marc Merritt, Melissa A. Riboli, Elio and Kaaks, Rudolf

Subjects
musculoskeletal diseases
Abstract

Background: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. Methods: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER-, n = 386), matched 1: 1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: The associations between OPG and ER+ and ER-breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER-breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24-3.02]; p(trend) = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER-disease did not differ by menopausal status at blood collection (p(het) = 0.97), and we observed no heterogeneity by HT use at blood collection (p(het) >= 0.43) or age at breast cancer diagnosis (p(het) >= 0.30). Conclusions: This study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER-breast cancer.

Published
2017

43. The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Sawada, Norie Wark, Petra A. Merritt, Melissa A. Tsugane, Shoichiro Ward, Heather A. Rinaldi, Sabina Weiderpass, Elisabete Dartois, Laureen His, Mathilde Boutron-Ruault, Marie-Christine Turzanski-Fortner, Renee Kaaks, Rudolf and Overvad, Kim Redondo, Maria-Luisa Travier, Noemie and Molina-Portillo, Elena Dorronsoro, Miren Cirera, Lluis and Ardanaz, Eva Perez-Cornago, Aurora Trichopoulou, Antonia and Lagiou, Pagona Valanou, Elissavet Masala, Giovanna Pala, Valeria Peeters, Petra H. M. van der Schouw, Yvonne T. and Melander, Olle Manjer, Jonas da Silva, Marisa Skeie, Guri and Tjonneland, Anne Olsen, Anja Gunter, Marc J. Riboli, Elio Cross, Amanda J.

Abstract

Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in similar to 253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: HRQ5 vs. Q1 = 1.11, 95% CI = 1.00-1.24; women: HRQ5 vs. Q1 = 1.17, 95% CI = 1.07-1.28). In contrast, height was inversely associated with circulatory disease mortality (men: HRQ5 vs. Q1 = 0.63, 95% CI = 0.56 - 0.71; women: HRQ5 vs. Q1 = 0.81, 95% CI = 0.70 - 0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: HRQ5 vs. Q1 = 0.64, 95% CI = 0.55 - 0.75; women: HRQ5 vs. Q1 = 0.60, 95% CI = 0.49 - 0.74) and respiratory disease mortality (men: HRQ5 vs. Q1 = 0.45, 95% CI = 0.28 - 0.71; women: HRQ5 vs. Q1 = 0.60, 95% CI = 0.40 - 0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.

Published
2017

44. Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Author

Zamora-Ros, Raul Barupal, Dinesh K. Rothwell, Joseph A. and Jenab, Mazda Fedirko, Veronika Romieu, Isabelle and Aleksandrova, Krasimira Overvad, Kim Kyro, Cecilie and Tjonneland, Anne Affret, Aurelie His, Mathilde and Boutron-Ruault, Marie-Christine Katzke, Verena Kuehn, Tilman and Boeing, Heiner Trichopoulou, Antonia Naska, Androniki and Kritikou, Maria Saieva, Calogero Agnoli, Claudia de Magistris, Maria Santucci Tumino, Rosario Fasanelli, Francesca and Weiderpass, Elisabete Skeie, Guri Merino, Susana and Jakszyn, Paula Sanchez, Maria-Jose Dorronsoro, Miren and Navarro, Carmen Ardanaz, Eva Sonestedt, Emily Ericson, Ulrika Nilsson, Lena Maria Boden, Stina Bueno-de-Mesquita, H. B. (as) Peeters, Petra H. Perez-Cornago, Aurora Wareham, Nicholas J. Khaw, Kay-Thee Freisling, Heinz Cross, Amanda J. and Riboli, Elio Scalbert, Augustin

Subjects
fungi, food and beverages, heterocyclic compounds
Abstract

Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.

Published
2017

45. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Author

Duarte Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron Ruault, Marie Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. B. As, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria Dolores, Dorronsoro, Miren, Quirós, J. Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, Jenab, Mazda, PANICO, SALVATORE, Duarte Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron Ruault, Marie Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. B. A, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria Dolore, Dorronsoro, Miren, Quirós, J. Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Kla, Wennberg, Maria, Khaw, Kay Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, and Jenab, Mazda

Subjects
Male, Cancer Research, European populations, Risk Factors, Surveys and Questionnaires, Surveys and Questionnaire, Prospective Studies, INDEX, Incidence, Liver Neoplasms, hepatocellular carcinoma, Middle Aged, CANCER, NUTRITIONAL EPIDEMIOLOGY, MEDITERRANEAN DIET, Europe, Nutritional Statu, Oncology, Liver Neoplasm, dietary fat, Female, Case-Control Studie, Life Sciences & Biomedicine, Human, Adult, Risk, Carcinoma, Hepatocellular, cohort study, dietary fats, Aged, Case-Control Studies, Diet, Dietary Fats, Feeding Behavior, Humans, Life Style, Nutritional Status, Young Adult, FISH, INFLAMMATION, LIVER-DISEASE, Oncology & Carcinogenesis, METAANALYSIS, Science & Technology, Risk Factor, Carcinoma, Hepatocellular, ACIDS, digestive system diseases, Prospective Studie, Food Habit, RISK-FACTORS, European population, Food Habits, 1112 Oncology And Carcinogenesis
Abstract

The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk. What's new? The rise of hepatocellular carcinoma (HCC) incidence in high- and middle-income countries, where relatively high-fat diets are common, suggests a possible etiological role for dietary fat. In the present study, potential associations between HCC and total fat intake, intake of fat subtypes and intake of fat from different sources were explored with data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Total fat intake, where monounsaturated fats predominated, was inversely associated with HCC risk. By contrast, no risk associations were detected for polyunsaturated or saturated fat intake or fat source.

Published
2015
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46. Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study.

Author

His, Mathilde, Biessy, Carine, Torres-Mejía, Gabriela, Ángeles-Llerenas, Angélica, Alvarado-Cabrero, Isabel, Sánchez, Gloria Inés, Borrero, Mauricio, Porras, Carolina, Rodriguez, Ana Cecilia, Garmendia, Maria Luisa, Olivier, Magali, Porter, Peggy L., Lin, MingGang, Gunter, Marc J., Romieu, Isabelle, Rinaldi, Sabina, PRECAMA team, Tejeda, Jenny, Navarro, Edgar, and Jaramillo, Roberto

Subjects
*ANTHROPOMETRY, *BREAST cancer patients, *OBESITY, *BODY mass index, *BODY weight
Abstract

Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20–45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1 kg/m2 = 0.93; 95% confidence interval = 0.89–0.96; waist circumference (WC): OR per 10 cm = 0.81 (0.69–0.96); hip circumference (HC): OR per 10 cm = 0.80 (0.67–0.95)). Height and leg length were not associated with risk. In normal weight women (18.5 ≤ BMI < 25), women with central obesity (WC > 88 cm) had an increased risk compared to women with normal WC (OR = 3.60(1.47–8.79)). Residuals of WC over BMI showed positive associations when adjusted for BMI (OR per 10 cm = 1.38 (0.98–1.94)). Body shape at younger ages and body shape evolution were not associated with risk. No heterogeneity was observed by receptor status. In this population of Latin American premenopausal women, different fat distributions in adulthood were differentially associated with risk of breast cancer. [ABSTRACT FROM AUTHOR]

Published
2020
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47. Influence of a cancer diagnosis on changes in fruit and vegetable consumption according to cancer site, stage at diagnosis and socioeconomic factors: Results from the large E3N‐EPIC study

Author

Affret, Aurélie, primary, His, Mathilde, additional, Severi, Gianluca, additional, Mancini, Francesca Romana, additional, Arveux, Patrick, additional, Clavel‐Chapelon, Françoise, additional, Boutron‐Ruault, Marie‐Christine, additional, and Fagherazzi, Guy, additional

Published
2018
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49. Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Molina-Montes, Esther, Sanchez, Maria-Jose, Buckland, Genevieve, Bueno-de-Mesquita, H. B(as), Weiderpass, Elisabete, Amiano, Pilar, Wark, Petra A., Kuehn, Tilman, Katzke, Verena, Maria Huerta, Jose, Ardanaz, Eva, Ramon Quiros, Jose, Affret, Aurelie, His, Mathilde, Boutron-Ruault, Marie-Christine, Peeters, Petra H., Ye, Weimin, Sund, Malin, Boeing, Heiner, Iqbal, Khalid, Ohlsson, Bodil, Sonestedt, Emily, Tjonneland, Anne, Petersen, Kristina E. N., Travis, Ruth C., Skeie, Guri, Agnoli, Claudia, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Sacerdote, Carlotta, Freisling, Heinz, Huybrechts, Inge, Overvad, Kim, Trichopoulou, Antonia, Bamia, Christina, Vasilopoulou, Effie, Wareham, Nick, Khaw, Kay-Tee, Cross, Amanda J., Ward, Heather A., Riboli, Elio, Duell, Eric J., Molina-Montes, Esther, Sanchez, Maria-Jose, Buckland, Genevieve, Bueno-de-Mesquita, H. B(as), Weiderpass, Elisabete, Amiano, Pilar, Wark, Petra A., Kuehn, Tilman, Katzke, Verena, Maria Huerta, Jose, Ardanaz, Eva, Ramon Quiros, Jose, Affret, Aurelie, His, Mathilde, Boutron-Ruault, Marie-Christine, Peeters, Petra H., Ye, Weimin, Sund, Malin, Boeing, Heiner, Iqbal, Khalid, Ohlsson, Bodil, Sonestedt, Emily, Tjonneland, Anne, Petersen, Kristina E. N., Travis, Ruth C., Skeie, Guri, Agnoli, Claudia, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Sacerdote, Carlotta, Freisling, Heinz, Huybrechts, Inge, Overvad, Kim, Trichopoulou, Antonia, Bamia, Christina, Vasilopoulou, Effie, Wareham, Nick, Khaw, Kay-Tee, Cross, Amanda J., Ward, Heather A., Riboli, Elio, and Duell, Eric J.

Abstract

Background: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs). Results: Adherence to the arMED score was not associated with risk of pancreatic cancer (HR highvs low adherence=0.99; 95% CI: 0.77–1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94–1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern. Conclusions: A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.

Published
2017
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50. Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Author

Zamora-Ros, Raul, Barupal, Dinesh K., Rothwell, Joseph A., Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Aleksandrova, Krasimira, Overvad, Kim, Kyro, Cecilie, Tjonneland, Anne, Affret, Aurelie, His, Mathilde, Boutron-Ruault, Marie-Christine, Katzke, Verena, Kuehn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Naska, Androniki, Kritikou, Maria, Saieva, Calogero, Agnoli, Claudia, de Magistris, Maria Santucci, Tumino, Rosario, Fasanelli, Francesca, Weiderpass, Elisabete, Skeie, Guri, Merino, Susana, Jakszyn, Paula, Sanchez, Maria-Jose, Dorronsoro, Miren, Navarro, Carmen, Ardanaz, Eva, Sonestedt, Emily, Ericson, Ulrika, Nilsson, Lena Maria, Bodén, Stina, Bueno-de-Mesquita, H. B. (as), Peeters, Petra H., Perez-Cornago, Aurora, Wareham, Nicholas J., Khaw, Kay-Thee, Freisling, Heinz, Cross, Amanda J., Riboli, Elio, Scalbert, Augustin, Zamora-Ros, Raul, Barupal, Dinesh K., Rothwell, Joseph A., Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Aleksandrova, Krasimira, Overvad, Kim, Kyro, Cecilie, Tjonneland, Anne, Affret, Aurelie, His, Mathilde, Boutron-Ruault, Marie-Christine, Katzke, Verena, Kuehn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Naska, Androniki, Kritikou, Maria, Saieva, Calogero, Agnoli, Claudia, de Magistris, Maria Santucci, Tumino, Rosario, Fasanelli, Francesca, Weiderpass, Elisabete, Skeie, Guri, Merino, Susana, Jakszyn, Paula, Sanchez, Maria-Jose, Dorronsoro, Miren, Navarro, Carmen, Ardanaz, Eva, Sonestedt, Emily, Ericson, Ulrika, Nilsson, Lena Maria, Bodén, Stina, Bueno-de-Mesquita, H. B. (as), Peeters, Petra H., Perez-Cornago, Aurora, Wareham, Nicholas J., Khaw, Kay-Thee, Freisling, Heinz, Cross, Amanda J., Riboli, Elio, and Scalbert, Augustin

Abstract

Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.

Published
2017
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