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345 results on '"Hiruta, Nobuyuki"'

3. Multidisciplinary Treatment for Lymphorrhea and Chylorrhea Following Lymph Node Dissection for Genitourinary Cancer.

Author

Kamiya, Naoto, Noro, Takahide, Okazaki, Taro, Ishitsuka, Naoki, Suzuki, Yuta, Iijima, Shota, Sugizaki, Yuka, Somoto, Takatoshi, Oka, Ryo, Utsumi, Takanobu, Endo, Takumi, Kasuya, Shusuke, Hiruta, Nobuyuki, and Suzuki, Hiroyoshi

Abstract

Simple Summary: Lymph node dissection (LND) damages the lymphatic pathway, leading to postoperative lymphorrhea and chylorrhea. Treatments for lymphorrhea include conservative treatment (e.g., fasting, total parenteral nutrition), drug therapy, interventional radiology (IR), and surgery. We reviewed the records of 28 patients at Toho University Sakura Medical Center with postoperative lymphorrhea or chylorrhea after LND that did not improve with conservative treatment. Based on our analysis, we partially revised the treatment algorithm for lymphorrhea developed by Rose et al. Octreotide was administered in twenty-seven patients, lymphangiography was performed in three patients, and lymphatic embolization was performed in one patient. Treatment success rates for octreotide and IR were 78.6% and 100%, respectively. The mean duration of drain placement after surgery for primary cancer was 18.3 ± 14.3 days. Patients with lymphorrhea and chylorrhea should be initially treated conservatively, with IR performed if conservative treatment is unsuccessful. Surgical treatment should be a last resort. Background: Lymph node dissection (LND) is often performed in genitourinary cancer to improve accurate staging. However, the resultant lymphatic damage often leads to postoperative lymphorrhea and chylorrhea. Further, since lymphatic fluid lacks platelets, it has very few clotting factors, and it is often difficult to treat postoperative lymphatic leakage. Treatments for lymphorrhea include conservative treatment (e.g., fasting, total parenteral nutrition, and drug therapy), interventional radiology (IR) and surgical treatment. However, there is no guideline of refractory lymphorrhea, and no clear criteria for switching to the next treatment. Methods: We reviewed the records of 28 patients at Toho University Sakura Medical Center with postoperative lymphorrhea or chylorrhea after LND that did not improve with conservative treatment. Based on this analysis, we partially revised the treatment algorithm for lymphorrhea developed by Rose et al. Results: The cases consisted of 26 men and two women, aged 65.0 ± 9.9 years. The mean number of lymph nodes removed was 25.3 ± 15.0. Octreotide was administered in 27 patients, lymphangiography was performed in three patients, and lymphatic embolization was performed in two patients. The mean duration of octreotide administration was 9.7 ± 6.1 days, and the mean dose was 211.1 µg/day. The treatment success rates with octreotide and IR were 78.6% and 100%, respectively. The mean duration of drain placement after surgery for primary cancer was 18.3 ± 14.3 days. Conclusions: Patients with lymphorrhea and chylorrhea should be initially treated conservatively, with IR performed if conservative treatment is unsuccessful. Surgical treatment should be a last resort. [ABSTRACT FROM AUTHOR]

Published
2025
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5. High presepsin concentrations in bile and its marked elevation in biliary tract diseases: A retrospective analysis

Author

Yamaguchi, Takashi, Ohira, Masahiro, Kawagoe, Naoyuki, Nakamura, Shoko, Tanaka, Sho, Oka, Rena, Watanabe, Yasuhiro, Sato, Yuta, Nagayama, Daiji, Saiki, Atsuhito, Matsuzawa, Yasuo, Bujo, Hideaki, Terai, Kensuke, Hiruta, Nobuyuki, Tatsuno, Ichiro, Nakaseko, Chiaki, Kikuchi, Hidemasa, Matsuoka, Katsuyoshi, Yokota, Hiromitsu, and Shimizu, Naomi

Published
2021
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6. Standardization of evaluation method and prognostic significance of histological response to preoperative chemotherapy in high-grade non-round cell soft tissue sarcomas

Author

Oda, Yoshinao, Tanaka, Kazuhiro, Hirose, Takanori, Hasegawa, Tadashi, Hiruta, Nobuyuki, Hisaoka, Masanori, Yoshimoto, Masato, Otsuka, Hiroshi, Bekki, Hirofumi, Ishii, Takeaki, Endo, Makoto, Kunisada, Toshiyuki, Hiruma, Toru, Tsuchiya, Hiroyuki, Katagiri, Hirohisa, Matsumoto, Yoshihiro, Kawai, Akira, Nakayama, Robert, Kawashima, Hiroyuki, Takenaka, Satoshi, Emori, Makoto, Watanuki, Munenori, Yoshida, Yukihiro, Okamoto, Takeshi, Mizusawa, Junki, Fukuda, Haruhiko, Ozaki, Toshifumi, Iwamoto, Yukihide, and Nojima, Takayuki

Published
2022
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9. Stepwise Transfer of Domain Knowledge for Computer-Aided Diagnosis in Pathology Using Deep Neural Networks

Author

Qu, Jia, Hiruta, Nobuyuki, Terai, Kensuke, Nosato, Hirokazu, Murakawa, Masahiro, Sakanashi, Hidenori, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Kotenko, Igor, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Roque, Ana, editor, Tomczyk, Arkadiusz, editor, De Maria, Elisabetta, editor, Putze, Felix, editor, Moucek, Roman, editor, Fred, Ana, editor, and Gamboa, Hugo, editor

Published
2020
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10. Cervical Mesonephric Adenocarcinoma Treated with Neoadjuvant Chemotherapy: A Case Report and a Literature Review.

Author

Ishida, Hiroaki, Manrai, Megumi, Egashira, Hiroki, Nonaka, Mizuki, Hiruta, Nobuyuki, Watanabe, Reiko, and Takashima, Akiko

Subjects
NEOADJUVANT chemotherapy, MIDDLE-aged women, CERVIX uteri tumors, CANCER invasiveness, SURGICAL margin
Abstract

Introduction: Cervical mesonephric ductal adenocarcinoma (MA) is an HPV-independent adenocarcinoma that occurs in middle-aged women. MA originates from remnants of the Wolffian duct that usually regress in females once the induction of sex differentiation is activated. MA is a rare disease that accounts for less than 1% of all cervical adenocarcinomas. Clinical Case: We report a case of MA in which abdominal radical hysterectomy (ARH) was performed after neoadjuvant chemotherapy (NAC). The patient was a 66-year-old woman with abnormal genital bleeding. A colposcopy examination revealed macroscopic invasive cancer. A pelvic MRI scan revealed a 53 × 26 mm tumor in the cervix, and the histological diagnosis of the cervix was endometrioid carcinoma, with the diagnosis being cervical adenocarcinoma cT1b3N0M0. One course of NAC with paclitaxel-carboplatin (PC) was administered to shrink the tumor and stop the bleeding, and ARH was performed. Postoperative histopathological diagnosis was MA. The surgical margins of the resected specimen were negative, and NAC had been effective, so the patient underwent five courses of PC therapy after surgery. There has been no recurrence 12 months after surgery. Conclusions: There is no established standard treatment, but there are reports that PC therapy is effective. It is necessary to search for effective treatments by following up and accumulating further cases. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Extended 73‐month survival in an elderly patient with BRAF V600E‐mutated lung adenocarcinoma: A case report.

Author

Namba, Kensuke, Isobe, Kazutoshi, Wakabayashi, Hiroki, Ohashi, Ryogo, Sakurai, Hiromasa, Sakai, Daiki, Irie, Yusuke, Takashima, Kenta, Murakami, Yu, Kaneko, Kaichi, Hiruta, Nobuyuki, and Matsuzawa, Yasuo

Subjects
OLDER patients, BRAF genes, PROTEIN kinases, LUNG cancer, CELL proliferation
Abstract

BRAF is a mediator that activates the mitogen‐activated protein kinase pathway. A mutation in BRAF can cause abnormal pathway activation, leading to cell proliferation. In a Phase II study, the combination therapy of the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib was found to be effective in non‐small cell lung cancer (NSCLC) patients with the BRAF mutation. However, this study has limited efficacy and safety data for elderly patients. We present a case of a patient who started treatment at 87 years old and showed a good prognosis, remaining alive 73 months from the start of treatment with no significant adverse events. The patient also maintained a partial response (PR) according to RECIST 1.1 at the last follow‐up. This case suggests that the dabrafenib and trametinib combination therapy is safe and effective for elderly NSCLC patients with the BRAF mutation. [ABSTRACT FROM AUTHOR]

Published
2024
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32. An Extremely Rare Case of Invasive Lobular Carcinoma of the Breast with Metastasis to the Stomach

Author

Arai, Manabu, Yoshida, Yutaka, Tanaka, Hiroshi, Sakakibara, Masahiro, Okazumi, Shinichi, and Hiruta, Nobuyuki

Subjects
immunostaining, breast cancer, metastatic gastric tumor, invasive lobular carcinoma
Abstract

Case Report, Breast cancer metastasis to the stomach is a rare occurrence. Among the breast cancer metastasis to the stomach, invasive lobular carcinoma (ILC) is mainly observed. Most of ILC with gastric metastasis have poor prognosis with metastases to other organs. We encountered a rare case of ILC with only gastric metastasis with long-term survival after multidisciplinary treatment. A 75-year-old woman was diagnosed with synchronous cancer of the breast (T2N1M0/Stage IIB) and stomach (T1N0M0/Stage I). At first, she underwent breast surgery. After chemotherapy and radiotherapy for ILC, distal gastrectomy was performed. Five years later, she was diagnosed with remnant gastric cancer and underwent total resection of the remnant stomach. Immunostaining of both gastric surgery specimens showed ILC metastasis to the stomach. If a gastric lesion is found in a breast cancer patient, we should consider the possibility of metastasis and use immunostaining methods to obtain an accurate pathologic diagnosis.

Published
2021

34. LR11, an LDL Receptor Gene Superfamily Member, Represses the Norepinephrine-Induced Expression of Uncoupling Protein 1 in Primary Cultured Beige Adipocytes

Author

Nakamura, Shoko, Jiang, Meizi, Oka, Rena, Yamaguchi, Takashi, Hiruta, Nobuyuki, Ebinuma, Hiroyuki, Schneider, J, Wolfgang, Tatsuno, Ichiro, and Bujo, Hideaki

Subjects
UCP1, beige, LR11, thermogenesis, adipogenesis
Abstract

Original Article, Introduction: The soluble form of LR11 (sLR11) inhibits thermogenesis via BMPs/TGFβ signaling pathways in adipocytes. Mice lacking LR11 are protected from diet-induced obesity associated with increased browning of subcutaneous white adipose tissue (WAT) and hypermetabolism. However, the mechanism underlying the recruitment of beige adipocytes has not been elucidated. In this paper, we have investigated the expression of LR11 in the differentiation and norepinephrine-induced activation of cultured beige adipocytes. Methods: LR11 mRNA levels were analyzed in cultured beige adipocytes differentiated from human immortalized adipose-derived stromal cells or from the subcutaneous WAT of wild-type (WT) and Lr11-/- mice. The concentrations of sLR11 were measured by an ELISA specific for murine sLR11. Results: In the course of browning adipogenesis of human stromal cells, LR11 mRNA levels decreased at the beginning and subsequently increased together with uncoupling protein (UCP) 1, β3-adrenergic receptor, lipoprotein lipase, and adiponectin. The LR11 transcript levels in the differentiated cells were transiently decreased by incubation with norepinephrine, and this change was in clear contrast to the increase of UCP1 mRNA levels. The mRNA levels of UCP1 in murine Lr11-/- beige adipocytes were significantly increased compared with those in WT beige adipocytes, regardless of norepinephrine stimulation. Finally, the amounts of sLR11 released from murine WT beige adipocytes were decreased by incubation with norepinephrine. Conclusions: LR11 potentially represses the norepinephrine-induced expression of UCP1 in Introduction: The soluble form of LR11 (sLR11) inhibits thermogenesis via BMPs/TGFβ signaling pathways in adipocytes. Mice lacking LR11 are protected from diet-induced obesity associated with increased browning of subcutaneous white adipose tissue (WAT) and hypermetabolism. However, the mechanism underlying the recruitment of beige adipocytes has not been elucidated. In this paper, we have investigated the expression of LR11 in the differentiation and norepinephrine-induced activation of cultured beige adipocytes. Methods: LR11 mRNA levels were analyzed in cultured beige adipocytes differentiated from human immortalized adipose-derived stromal cells or from the subcutaneous WAT of wild-type (WT) and Lr11-/- mice. The concentrations of sLR11 were measured by an ELISA specific for murine sLR11. Results: In the course of browning adipogenesis of human stromal cells, LR11 mRNA levels decreased at the beginning and subsequently increased together with uncoupling protein (UCP) 1, β3-adrenergic receptor, lipoprotein lipase, and adiponectin. The LR11 transcript levels in the differentiated cells were transiently decreased by incubation with norepinephrine, and this change was in clear contrast to the increase of UCP1 mRNA levels. The mRNA levels of UCP1 in murine Lr11-/- beige adipocytes were significantly increased compared with those in WT beige adipocytes, regardless of norepinephrine stimulation. Finally, the amounts of sLR11 released from murine WT beige adipocytes were decreased by incubation with norepinephrine. Conclusions: LR11 potentially represses the norepinephrine-induced expression of UCP1 in differentiated beige adipocytes. The sLR11-mediated repression of the key molecule in thermogenesis may be involved in the sympathetic activation of the recruitment of beige adipocytes in subcutaneous fat.

Published
2021

39. SIGNIFICANCE OF IgG4 IN IDIOPATHIC RETROPERITONEAL FIBROSIS

Author

Sanda, Masaaki, primary, Kamiya, Naoto, additional, Sugizaki, Yuka, additional, Mori, Takamichi, additional, Sugiyama, Masayasu, additional, Kato, Seiji, additional, Oka, Ryo, additional, Utsumi, Takanobu, additional, Endo, Takumi, additional, Yano, Masashi, additional, Hiruta, Nobuyuki, additional, and Suzuki, Hiroyoshi, additional

Published
2021
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40. S100-negative epithelioid malignant peripheral nerve sheath tumor with possible perineurial differentiation

Author

Yamashita, Kyoko, primary, Funauchi, Yuki, additional, Hayakawa, Keiko, additional, Ae, Keisuke, additional, Matsumoto, Seiichi, additional, Ikuta, Kunihiro, additional, Nishida, Yoshihiro, additional, Ueno, Teruko, additional, Shimoyama, Yoshie, additional, Hiruta, Nobuyuki, additional, Machinami, Rikuo, additional, Kawachi, Hiroshi, additional, and Takeuchi, Kengo, additional

Published
2021
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44. Standardization of Evaluation Method and Prognostic Significance of Histological Response to Preoperative Chemotherapy in High-grade Non-round Cell Soft Tissue Sarcomas: a Report From the Central Pathology Review for the Japan Clinical Oncology Group Study JCOG0304

Author

Oda, Yoshinao, primary, Tanaka, Kazuhiro, additional, Hirose, Takanori, additional, Hasegawa, Tadashi, additional, Hiruta, Nobuyuki, additional, Hisaoka, Masanori, additional, Yoshimoto, Masato, additional, Otsuka, Hiroshi, additional, Bekki, Hirofumi, additional, Ishii, Takeaki, additional, Endo, Makoto, additional, Kunisada, Toshiyuki, additional, Hiruma, Toru, additional, Tsuchiya, Hiroyuki, additional, Katagiri, Hirohisa, additional, Matsumoto, Yoshihiro, additional, Kawai, Akira, additional, Nakayama, Robert, additional, Kawashima, Hiroyuki, additional, Takenaka, Satoshi, additional, Emori, Makoto, additional, Watanuki, Munenori, additional, Yoshida, Yukihiro, additional, Okamoto, Takeshi, additional, Mizusawa, Junki, additional, Fukuda, Haruhiko, additional, Ozaki, Toshifumi, additional, Iwamoto, Yukihide, additional, and Nojima, Takayuki, additional

Published
2021
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49. Coexistence of Marfan-like Connective Tissue Disease with Morphologic Left Ventricular Non-compaction

Author

Yashima, Satomi, primary, Takaoka, Hiroyuki, additional, Iwahana, Togo, additional, Takahashi, Manami, additional, Kondo, Yusuke, additional, Ueda, Hideki, additional, Saito, Aya, additional, Ito, Yuya, additional, Motomura, Noboru, additional, Hiruta, Nobuyuki, additional, Ikeda, Jun-ichiro, additional, Matsumiya, Goro, additional, and Kobayashi, Yoshio, additional

Published
2020
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