162 results on '"Hiroyuki, Ohnishi"'
Search Results
2. Successful surgical resection and reconstruction of scrotal elephantiasis
- Author
-
Yuto Hattori, Naoki Hayata, Kenji Nakamura, Takeshi Takahashi, Kenji Mitsumori, and Hiroyuki Ohnishi
- Subjects
elephantiasis ,genitalia ,lymphedema ,reconstructive surgical procedures ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Introduction An enlarged scrotum due to scrotal elephantiasis results in a poor quality of life. This condition is uncommon and challenging to manage for most urologists. We report a case of scrotal elephantiasis treated with resection and scrotal reconstruction. Case presentation A 57‐year‐old man was referred to our hospital with a 6‐year history of scrotal swelling. The scrotum was 20 cm in diameter, stiff, and thick. He was diagnosed with chronic scrotal lymphedema and underwent scrotal resection. The skin and subcutaneous tissues of the scrotum were excised, and the suprapubic skin, which was stretched by the enlarged scrotum, was used for the scrotal reconstruction. The penis was pulled out from this hole in the skin. Conclusion Utilizing suprapubic skin flap for scrotal reconstruction is an effective treatment for scrotal elephantiasis that can result in functionally and cosmetically successful outcomes.
- Published
- 2021
- Full Text
- View/download PDF
3. POSTER: Fine-grained Network Identification and Control Combining Routers and Programmable Switches.
- Author
-
Yuki Takei, Satoshi Nakatsukasa, Masato Nishiguchi, and Hiroyuki Ohnishi
- Published
- 2021
- Full Text
- View/download PDF
4. Endovascular Treatment of Idiopathic Intracranial Hypertension with Stenting of the Transverse Sinus Stenosis
- Author
-
Shigeru Miyachi, Ryo Hiramatsu, Hiroyuki Ohnishi, Kenkichi Takahashi, and Toshihiko Kuroiwa
- Subjects
idiopathic intracranial hypertension ,transvers sinus ,stenting ,Medicine (General) ,R5-920 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
For many years, the pathophysiology of idiopathic intracranial hypertension (IIH) was interpreted as “secondary intracranial hypertension,” and IIH was considered to be caused by brain edema due to obstructive sleep apnea. Another theory proposed cerebrospinal fluid (CSF) absorption impairment due to excessive medication with vitamin A derivatives. Other reports pointed out the importance of obesity, which may cause an impairment of intracranial venous drainage due to elevated right atrial pressure. Patients with medically refractory IIH have traditionally undergone a CSF diversion. Venous outlet impairment on IIH has recently been reported as a causative or contributory cause, and thus focused venoplasty of the stenotic sinus with a stent has emerged as a new treatment strategy. We report the cases of two patients who presented with headache and papilledema with IIH. They successfully underwent stent placement at the stenosis of the transverse sinus and experienced complete resolution of symptoms.
- Published
- 2018
- Full Text
- View/download PDF
5. Method for Estimating Locations of Service Problem Causes in Service Function Chaining.
- Author
-
Aiko Oi, Daiki Endou, Takaaki Moriya, and Hiroyuki Ohnishi
- Published
- 2015
- Full Text
- View/download PDF
6. Usefulness of the Pipeline Embolic Device for Large and Giant Carotid Cavernous Aneurysms
- Author
-
Shigeru Miyachi, Ryo Hiramatsu, Hiroyuki Ohnishi, Ryokichi Yagi, and Toshihiko Kuroiwa
- Subjects
carotid cavernous aneurysm ,endovascular treatment ,flow diverter ,pipeline™ embolic device ,Medicine (General) ,R5-920 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
PurposeConventional coil embolization for large carotid cavernous aneurysms (CCAs) has limited utility due to its inability to prevent recurrences and reduce mass effect. Trapping of the parent artery may have a risk of ischemic complications due to intracranial perfusion disorders. We successfully treated 24 patients with large CCAs using a flow diverter (Pipeline™ embolic device: PED), and this report discusses the safety and efficacy of this method.Materials and MethodsTwenty four patients (23 females, mean age 71.5 years old) with large CCAs, including 6 giant CCAs, were treated with a PED over three years. Under sufficient dual anti-platelet management, the PED was deployed over the orifice of the aneurysm. Two patients required multiple telescoping stents. Clinical and radiological states were checked with MRI at 1, 3 and 6 months post-surgically. Angiographic follow-up was performed at 6 months.ResultsIn all patients, PED was appropriately deployed. Stagnation of contrast with eclipse signs was observed post-angiogram in 21 cases. One patient requiring 5 telescoping stents experienced temporary ischemic symptoms. Fourteen patients experienced improvement of ocular motor impairment deficiency, including 6 patients who recovered. Angiograms at 6 months follow-up showed complete occlusion in 63% (12/19) of patients, and MRI showed reduction of aneurysm volume in 89% (17/19) of patients.ConclusionFlow diverters for large CCAs showed promising clinical and radiological efficacy. They can shrink the aneurysm and improve symptoms without sacrificing the parent artery. It will be necessary to summarize the cases and to verify the long-term results.
- Published
- 2017
- Full Text
- View/download PDF
7. Fast xFlow Proxy: Exploring and Visualizing Deep Inside of Carrier Traffic
- Author
-
Morioka Chiharu, Miyoshi Yuki, Hayashi Yuhei, Shohei Kamamura, Hiroyuki Ohnishi, and Nishioka Takeaki
- Subjects
Computer Networks and Communications ,Computer science ,Real-time computing ,Electrical and Electronic Engineering ,Proxy (statistics) ,Software - Published
- 2022
- Full Text
- View/download PDF
8. Treatment Outcomes of 94 Cases of Pipeline Embolization Device in a Single Center: Predictive Factors of Incomplete Aneurysm Occlusion.
- Author
-
Ryo Hiramatsu, Ryokichi Yagi, Masahiro Kameda, Naosuke Nonoguchi, Motomasa Furuse, Shinji Kawabata, Hiroyuki Ohnishi, Shigeru Miyachi, and Masahiko Wanibuchi
- Subjects
THERAPEUTIC embolization ,INTERNAL carotid artery ,CORONARY angiography ,POSTOPERATIVE period ,MULTIVARIATE analysis - Abstract
Objective: This study aimed to report the outcome of an endovascular treatment with a pipeline embolization device (PED) at a single center. We also examined the predictive factors for an incomplete occlusion after the PED placement. Methods: The subjects were 94 patients with 109 aneurysms who underwent the PED placement at our single center from June 2015 to September 2022. As treatment outcomes, we investigated the PED placement success rate, perioperative morbidity and mortality, postoperative cranial nerve improvement rate, and the classification of angiographic result at 6 months after the PED placement. Furthermore, the predictors of an incomplete occlusion were investigated in detail. Results: One hundred nine aneurysms locations were: C1 (9), C2 (30), C3 (15), C4 (53), and C5 (2) in the internal carotid artery segments. Perioperative morbidity, including the asymptomatic ones, occurred in 10 cases (10.6%). Among these 10 cases, the modified Rankin Scale (mRS) improved to preoperative mRS after 90 days in 9 cases except 1 case. On the other hand, no perioperative mortality was observed. The postoperative cranial nerve improvement rate was 84.4%, and 61.7% of patients had a complete occlusion in the follow-up angiography, 6 months after the PED placement. Predictive factors for an incomplete occlusion after the PED placement were the elderly aged 70 years or older (P-value = 0.0214), the elderly aged 75 years or older (P-value = 0.0009), and the use of anticoagulants (P-value = 0.0388) in an univariate analysis. Further, the multivariate analysis revealed that the elderly aged 75 years or older was a predictive factor of an incomplete occlusion in this study. Conclusion: We summarized the outcomes of the PED treatment at our single center. In this study, the elderly aged 75 years or older was a predictive factor of an incomplete occlusion after the PED placement. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
9. Latest trends of advanced reactor development supporting nuclear innovation (3)
- Author
-
Kazumasa Suyama, Hiroyuki Ohnishi, Kaoru Kurabayashi, Takayuki Nakano, and Satoshi Yonemoto
- Subjects
Nuclear Energy and Engineering - Published
- 2022
- Full Text
- View/download PDF
10. Rate-equation approach to optimal density ratio of K-Rb hybrid cells for optically pumped atomic magnetometers.
- Author
-
Yosuke Ito, Hiroyuki Ohnishi, Keigo Kamada, and Tetsuo Kobayashi
- Published
- 2013
- Full Text
- View/download PDF
11. Endovascular Therapy in Ischemic Stroke With Acute Large‐Vessel Occlusion: Recovery by Endovascular Salvage for Cerebral Ultra‐Acute Embolism Japan Registry 2
- Author
-
Shinichi Yoshimura, Nobuyuki Sakai, Kazutaka Uchida, Hiroshi Yamagami, Masayuki Ezura, Yasushi Okada, Kazuo Kitagawa, Kazumi Kimura, Makoto Sasaki, Norio Tanahashi, Kazunori Toyoda, Eisuke Furui, Yuji Matsumaru, Kazuo Minematsu, Takeshi Morimoto, Naoya Kuwayama, Kuniaki Ogasawara, Koji Iihara, Masataka Takeuchi, Masafumi Morimoto, Toshiyuki Onda, Masunari Shibata, Takahiro Ohta, Keisuke Imai, Ryo Itabashi, Taro Yamashita, Norihito Fukawa, Naoto Kimura, Ryosuke Doijiri, Hajime Ohta, Yukiko Enomoto, Chisaku Kanbayashi, Ikuya Yamaura, Hideyuki Ishihara, Yuki Kamiya, Makoto Hayase, Kouhei Nii, Junya Kobayashi, Hiroaki Yasuda, Ryushi Kondo, Daisuke Yamamoto, Manabu Sakaguchi, Junichiro Satomi, Yoshiki Yagita, Akira Handa, Atsushi Shindo, Nagayasu Hiyama, Naoki Toma, Tomoyuki Tsumoto, Wataro Tsuruta, Keigo Matsumoto, Yoshihiro Kiura, Takaaki Yamazaki, Taketo Hatano, Yoshihisa Matsumoto, Takao Kojima, Norio Ikeda, Shigeyuki Sakamoto, Hiroyuki Ohnishi, Koichi Haraguchi, and Naoyuki Uchiyama
- Subjects
endovascular therapy ,large‐vessel occlusion ,propensity score ,registry ,stroke ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundEndovascular therapy has been shown to be effective in patients with acute cerebral large‐vessel occlusion, but real‐world efficacies are unknown. Methods and ResultsWe conducted a prospective registry at 46 centers between October 2014 and January 2017. Eligible patients were those who were aged 20 years or older, with acute cerebral large‐vessel occlusion, and who were hospitalized within 24 hours of the onset. We enrolled both consecutive patients who were treated with or without endovascular therapy. Endovascular therapy included thrombectomy, balloon angioplasty, stenting, local fibrinolysis, and piercing. The primary outcome was a favorable outcome as defined by a modified Rankin Scale of 0 to 2 at 90 days after onset. Secondary outcomes were modified Rankin Scale of 0 to 1 and mortality. Safety outcomes were intracerebral hemorrhage or a recurrence of ischemic stroke. We constructed the 2242 (1121 each) propensity score–matched patients cohort based on a propensity score for endovascular therapy and estimated the adjusted odds ratio, followed by sensitivity analyses on original 2399 (1278 in endovascular therapy versus 1121 in no endovascular therapy) patients. In the propensity score–matched cohort, favorable outcomes were observed in 35.3% and 30.7% of patients in the endovascular therapy and no endovascular therapy groups, respectively (P=0.02). The adjusted odds ratio for the favorable outcome was 1.44 (95% confidence interval, 1.10–1.86, P=0.007). The efficacy of endovascular therapy in achieving favorable outcomes did not differ between our subgroups and in the sensitivity analyses. ConclusionsEndovascular therapy decreased disabilities at 90 days in real‐world patients with acute cerebral large‐vessel occlusion. Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02419794.
- Published
- 2018
- Full Text
- View/download PDF
12. Study of Service Processing Agent for Context-Aware Service Coordination.
- Author
-
Yoji Yamato, Hiroyuki Ohnishi, and Hiroshi Sunaga
- Published
- 2008
- Full Text
- View/download PDF
13. Practical Study on Providing Event-Driven Composite Services for Telecom-Enterprise Convergence.
- Author
-
Takaaki Moriya, Yuichi Nakatani, Hiroyuki Ohnishi, Makoto Yoshida, and Miki Hirano
- Published
- 2008
- Full Text
- View/download PDF
14. Efficient Information Searching Methods Based on User Utility in Super Distributed Environments.
- Author
-
Shinji Sugawara, Hiroyuki Ohnishi, and Yutaka Ishibashi
- Published
- 2008
- Full Text
- View/download PDF
15. Development of Service Control Server for Web-Telecom Coordination Service.
- Author
-
Yoji Yamato, Hiroyuki Ohnishi, and Hiroshi Sunaga
- Published
- 2008
- Full Text
- View/download PDF
16. A Method of Bridging and Processing Media Stream on Network.
- Author
-
Satoshi Kondoh, Takaaki Moriya, Hiroyuki Ohnishi, and Miki Hirano
- Published
- 2008
- Full Text
- View/download PDF
17. Service Delivery Platform for Telecom-Enterprise-Internet Combined Services.
- Author
-
Hiroyuki Ohnishi, Yoji Yamato, Masashi Kaneko, Takaaki Moriya, Miki Hirano, and Hiroshi Sunaga
- Published
- 2007
- Full Text
- View/download PDF
18. Dataflow Generation for Service Composition to Incorporate Web and Telecommunication.
- Author
-
Takaaki Moriya, Hiroyuki Ohnishi, Makoto Yoshida, and Miki Hirano
- Published
- 2007
- Full Text
- View/download PDF
19. A Support System for Designing Ubiquitous Service Composition Scenarios.
- Author
-
Takaaki Moriya, Hiroyuki Ohnishi, Makoto Yoshida, Takeshi Ogawa, and Miki Hirano
- Published
- 2007
- Full Text
- View/download PDF
20. Coil Embolization of Unruptured Distal Anterior Cerebral Artery Aneurysm Using a Marathon Microcatheter
- Author
-
Kenji Fukutome, Hiroyuki Ohnishi, Yoshihiro Kuga, and Hideyuki Ohnishi
- Subjects
General Engineering - Published
- 2022
- Full Text
- View/download PDF
21. Clinical Outcome of Patients With Large Vessel Occlusion and Low National Institutes of Health Stroke Scale Scores
- Author
-
Takuya Saito, Ryo Itabashi, Yukako Yazawa, Kazutaka Uchida, Hiroshi Yamagami, Nobuyuki Sakai, Takeshi Morimoto, Shinichi Yoshimura, Ryosuke Doijiri, Yukiko Enomoto, Masayuki Ezura, Norihito Fukawa, Eisuke Furui, Akira Handa, Koichi Haraguchi, Taketo Hatano, Makoto Hayase, Nagayasu Hiyama, Koji Iihara, Norio Ikeda, Keisuke Imai, Hideyuki Ishihara, Yuki Kamiya, Chisaku Kanbayashi, Kazumi Kimura, Kazuo Kitagawa, Yoshihiro Kiura, Junya Kobayashi, Takao Kojima, Ryushi Kondo, Naoya Kuwayama, Yuji Matsumaru, Keigo Matsumoto, Yoshihisa Matsumoto, Kazuo Minematsu, Masafumi Morimoto, Kohei Nii, Kuniaki Ogasawara, Hiroyuki Ohnishi, Hajime Ohta, Takahiro Ohta, Yasushi Okada, Toshiyuki Onda, Manabu Sakaguchi, Shigeyuki Sakamoto, Makoto Sasaki, Junichiro Satomi, Masunari Shibata, Atsushi Shindo, Masataka Takeuchi, Norio Tanahashi, Naoki Toma, Kazunori Toyoda, Tomoyuki Tsumoto, Wataro Tsuruta, Naoyuki Uchiyama, Yoshiki Yagita, Taro Yamashita, Daisuke Yamamoto, Ikuya Yamaura, Takaaki Yamazaki, and Hiroaki Yasuda
- Subjects
Male ,medicine.medical_specialty ,Multivariate analysis ,Brain Ischemia ,Modified Rankin Scale ,Internal medicine ,Post-hoc analysis ,medicine ,Humans ,Stroke ,Aged ,Advanced and Specialized Nursing ,Stroke scale ,business.industry ,Clinical Studies as Topic ,Endovascular Procedures ,Odds ratio ,Middle Aged ,medicine.disease ,United States ,Intracranial Embolism ,National Institutes of Health (U.S.) ,Tissue Plasminogen Activator ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Plasminogen activator ,Large vessel occlusion - Abstract
Background and Purpose— The treatment and prognosis of acute large vessel occlusion with mild symptoms have not been sufficiently studied. The present study aimed to investigate the clinical or radiological predictors of clinical outcome in patients with stroke with mild symptoms due to acute large vessel occlusion. Methods— Of 2420 patients with acute large vessel occlusion in the RESCUE-Japan Registry 2 (Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism-Japan Registry 2), a multicenter prospective registry in Japan, patients with modified Rankin Scale scores of 0 to 2 before onset and initial National Institutes of Health Stroke Scale (NIHSS) scores of 0 to 5 were examined in post hoc analysis. We examined the clinical and radiological characteristics associated with a favorable outcome (modified Rankin Scale score, 0–2 at 90 days) using multivariate analysis, as well as the factors associated with a favorable outcome in patients treated with endovascular therapy. Results— We analyzed 272 patients (median age, 73 years; median NIHSS score on admission, 3). Eighty-six (31.6%) patients were treated with intravenous recombinant tissue-type plasminogen activator, 54 (19.9%) underwent endovascular therapy, and 208 (76.5%) showed a favorable outcome. In multivariate analysis, age P Conclusions— Younger age, lower initial NIHSS score, intravenous recombinant tissue-type plasminogen activator, and absence of hyperglycemia were independently associated with a favorable outcome in patients with acute large vessel occlusion with low NIHSS scores. Registration— URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02419794.
- Published
- 2020
- Full Text
- View/download PDF
22. A thread of hope for successful revascularization for acute embolic basilar artery occlusion due to miserable vertebral artery stump syndrome. A technical report
- Author
-
Ryosuke Maeoka, Ichiro Nakagawa, Hideyuki Ohnishi, Hiroyuki Ohnishi, Hiroyuki Nakase, and Yoshihiro Kuga
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Vertebral artery ,Embolism ,Revascularization ,Magnetic resonance angiography ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Embolus ,Physiology (medical) ,Internal medicine ,medicine.artery ,Occlusion ,Humans ,Medicine ,In patient ,Lateral Medullary Syndrome ,Vertebral Artery ,Aged ,Thrombectomy ,Cerebral Revascularization ,medicine.diagnostic_test ,business.industry ,Mortality rate ,Basilar artery occlusion ,General Medicine ,Middle Aged ,Stroke ,Neurology ,Basilar Artery ,030220 oncology & carcinogenesis ,Cardiology ,Female ,Surgery ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Acute basilar artery occlusion (BAO) is associated with major morbidities and a high mortality rate. The prevalence of acute BAO is 10.4% among patients treated with thrombectomy for acute large vessel occlusion. Vertebral artery stump syndrome (VASS) reportedly causes ischemic stroke with tandem occlusions as vertebral artery (VA) origin occlusion and BAO. The pathogenesis of ischemic stroke due to VASS can be attributed to thrombi or emboli. Acute embolic BAO due to VASS accounted for 2 of 25 cases (8.0%) of BAO treated using thrombectomy between April 2014 and May 2019 in our registry. VASS must be considered as one cause of BAO. With the initial Magnetic resonance angiography on arrival, it is difficult to distinguish between BAO due to simple cardiogenic embolus and due to embolus caused by VASS rapidly. In patients suffering from acute embolic BAO due to VASS, the presence of VA origin occlusion makes endovascular therapy (EVT) difficult to perform. Here, we report consecutive cases of thrombectomy for acute embolic BAO due to VASS, showing markedly different outcomes. VA origin occlusion severely limits the technical options for EVT. Visualization or conjecture of the origin of both or dominant VAs conceivably offers the possibility of successful EVT and may allow good outcomes.
- Published
- 2020
- Full Text
- View/download PDF
23. A Patient with a Large Aneurysm Complicated by Stenosis of the Internal Carotid Artery Distal to the Aneurysm in Whom Treatment Using a Pipeline Flex Was Performed
- Author
-
Ryokichi Yagi, Ryo Hiramatsu, Shigeru Miyachi, Toshihiko Kuroiwa, Masahiko Wanibuchi, and Hiroyuki Ohnishi
- Subjects
medicine.medical_specialty ,business.industry ,Pipeline (computing) ,Large aneurysm ,medicine.disease ,Stenosis ,Aneurysm ,medicine.artery ,medicine ,FLEX ,Neurology (clinical) ,Radiology ,Internal carotid artery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2020
- Full Text
- View/download PDF
24. Intracerebral Hemorrhage after Endovascular Treatment of Unruptured Intracerebral Aneurysm: A Case Report and Review of the Literature
- Author
-
Toshihiko Kuroiwa, Adam Tucker, Shigeru Miyachi, Hiroyuki Ohnishi, and Ryo Hiramatsu
- Subjects
Intracerebral hemorrhage ,medicine.medical_specialty ,Aneurysm ,business.industry ,medicine ,Endovascular treatment ,medicine.disease ,business ,Surgery ,Flow diverter - Published
- 2020
- Full Text
- View/download PDF
25. Other Hospital-onset Acute Ischemic Stroke Due to Large Vessel Occlusion Treated by Mechanical Thrombectomy after Inter-hospital Transfer
- Author
-
Ryokichi Yagi, Koji Takeuchi, Yuichiro Tsuji, Ryo Hiramatsu, Noriaki Matsubara, Yangtae Park, Shigeru Miyachi, Hiroyuki Ohnishi, and Toshihiko Kuroiwa
- Subjects
Male ,Patient Transfer ,Time Factors ,Medical staff ,thrombectomy-incapable hospital ,Treatment results ,in-hospital stroke ,Time-to-Treatment ,030218 nuclear medicine & medical imaging ,mechanical thrombectomy ,03 medical and health sciences ,0302 clinical medicine ,Modified Rankin Scale ,large vessel occlusion ,Humans ,Medicine ,In hospital stroke ,Stroke ,Acute ischemic stroke ,Aged ,Ischemic Stroke ,Retrospective Studies ,Thrombectomy ,Aged, 80 and over ,business.industry ,Middle Aged ,medicine.disease ,Mechanical thrombectomy ,Cerebrovascular Disorders ,Treatment Outcome ,Anesthesia ,inter-hospital transfer ,Original Article ,Female ,Surgery ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Large vessel occlusion - Abstract
The purpose of this study was to investigate the in-hospital acute ischemic stroke due to large vessel occlusion (LVO) that developed in another thrombectomy-incapable hospital, treated by mechanical thrombectomy after inter-hospital transfer. In eight other hospital-onset LVO patients, clinical characteristics, treatment results, and the timeline of thrombectomy were retrospectively investigated and compared to the results of 17 patients developed LVO at our own hospital and 18 developed in the community. In the analysis of timeline, the mean recognition-to-arrival time in other hospital-onset patients was 169 ± 78 min, significantly longer than for the community-onset patients (79 ± 78 min). Arrival-to-puncture time was 42 ± 19 min, significantly shorter than for the own hospital-onset patients (166 ± 80 min) and the community-onset patients (155 ± 76 min). Recognition-to-puncture times for the other hospital-onset patients, the own hospital-onset patients, and the community-onset patients were 212 ± 74, 166 ± 80, and 216 ± 83 min, respectively, and recognition-to-recanalization times were 285 ± 73, 200 ± 81, and 275 ± 125 min. Both these times were shorter for the own hospital-onset patients. The rates of modified Rankin Scale (mRS) of 0-2 in the three groups were 12%, 30%, and 23%, respectively. The rate of mRS 0-2 was lowest in the other hospital-onset patients. In conclusion, the other hospital-onset patients required additional time for their initial management and inter-hospital transfer although arrival-to-puncture time was shorter. Favorable outcomes were observed less frequently in them. Improving inter-hospital cooperation systems and to educate the medical staff in a thrombectomy-incapable hospital concerning stroke management is important measures for other hospital-onset stroke with LVO.
- Published
- 2020
- Full Text
- View/download PDF
26. Efforts to shorten time from patient presentation to thrombectomy in acute ischemic stroke
- Author
-
Fumiya Sato, Hiroyuki Ohnishi, Kenkichi Takahashi, Yoshihiro Kuga, Hideyuki Ohnishi, and Ryosuke Maeoka
- Subjects
medicine.medical_specialty ,business.industry ,Emergency medicine ,Medicine ,General Medicine ,Presentation (obstetrics) ,business ,Acute ischemic stroke - Published
- 2020
- Full Text
- View/download PDF
27. Multi-homing for small scale fixed network Using Mobile IP and NEMO.
- Author
-
Kenichi Nagami, Satoshi Uda, Nobuo Ogashiwa, Hiroshi Esaki, Ryuji Wakikawa, and Hiroyuki Ohnishi
- Published
- 2007
- Full Text
- View/download PDF
28. Multilink System with Available Bandwidth Estimation in Nomadic Network Environment.
- Author
-
Takaaki Moriya, Hiroyuki Ohnishi, Takeshi Ogawa, Tadashi Ito, and Miki Hirano
- Published
- 2007
- Full Text
- View/download PDF
29. POSTER: Fine-grained Network Identification and Control Combining Routers and Programmable Switches
- Author
-
Nakatsukasa Satoshi, Masato Nishiguchi, Hiroyuki Ohnishi, and Takei Yuki
- Subjects
Router ,Network packet ,Computer science ,computer.internet_protocol ,business.industry ,Routing table ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Multiprotocol Label Switching ,Access control ,Identification (information) ,Control system ,MPLS VPN ,business ,computer ,Computer network - Abstract
In this paper, we propose a fine-grained packet identification and control technique using a combination of commercial routers and programmable switches in existing IP networks. This technique enhances the control of existing users' communication in large-scale networks such as carrier networks, by utilizing the large amount of user-premises equipment and terminals already installed without modifying as much as possible. The packet identification in commercial routers involves not only identifying the destination address by the routing table but also filtering the arriving packets for access control. However, in large networks, the number of entries in the router can easily exceed the upper limit of the specification due to the bloated number of entries. The purpose of our proposal is to introduce programmable switches to apply fine-grained entries to specific packets roughly identified by commercial routers, thereby distributing the entries and achieving fine-grained packet identification even in large-scale networks. In our demonstration, we will target an MPLS VPN network and demonstrate how to forward packets of only specific users to P4 switches and how to flow only specific applications to high priority paths.
- Published
- 2021
- Full Text
- View/download PDF
30. Successful surgical resection and reconstruction of scrotal elephantiasis
- Author
-
Kenji Mitsumori, Naoki Hayata, Kenji Nakamura, Takeshi Takahashi, Yuto Hattori, and Hiroyuki Ohnishi
- Subjects
Surgical resection ,endocrine system ,medicine.medical_specialty ,endocrine system diseases ,Urology ,medicine.medical_treatment ,Case Report ,Case Reports ,Elephantiasis ,lcsh:RC870-923 ,urologic and male genital diseases ,Scrotum ,SCROTAL ELEPHANTIASIS ,Medicine ,Effective treatment ,elephantiasis ,Suprapubic cystostomy ,urogenital system ,business.industry ,genitalia ,lymphedema ,lcsh:Diseases of the genitourinary system. Urology ,medicine.disease ,reconstructive surgical procedures ,Surgery ,Lymphedema ,medicine.anatomical_structure ,business ,Penis - Abstract
Introduction An enlarged scrotum due to scrotal elephantiasis results in a poor quality of life. This condition is uncommon and challenging to manage for most urologists. We report a case of scrotal elephantiasis treated with resection and scrotal reconstruction. Case presentation A 57-year-old man was referred to our hospital with a 6-year history of scrotal swelling. The scrotum was 20 cm in diameter, stiff, and thick. He was diagnosed with chronic scrotal lymphedema and underwent scrotal resection. The skin and subcutaneous tissues of the scrotum were excised, and the suprapubic skin, which was stretched by the enlarged scrotum, was used for the scrotal reconstruction. The penis was pulled out from this hole in the skin. Conclusion Utilizing suprapubic skin flap for scrotal reconstruction is an effective treatment for scrotal elephantiasis that can result in functionally and cosmetically successful outcomes.
- Published
- 2020
- Full Text
- View/download PDF
31. Overlapping Stents with Coil Sandwich for Ruptured Blood-blister Aneurysm in a Patient with Ipsilateral Persistent Primitive Trigeminal Artery: A Case Report and Review of Literature
- Author
-
Ryosuke Maeoka, Hiroyuki Nakase, Ichiro Nakagawa, and Hiroyuki Ohnishi
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Case Report ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,High morbidity ,0302 clinical medicine ,Aneurysm ,overlapping stent ,medicine.artery ,medicine ,cardiovascular diseases ,Coil sandwich ,business.industry ,Stent ,General Medicine ,Blood flow ,medicine.disease ,ruptured blood-blister aneurysm ,Surgery ,medicine.anatomical_structure ,Blood blister ,Concomitant ,Trigeminal artery ,Internal carotid artery ,business ,030217 neurology & neurosurgery - Abstract
Ruptured blood-blister aneurysms (RBBAs) of the intracranial internal carotid artery (ICA) are associated with high morbidity and mortality. RBBA has been treated with trapping with high-flow bypass avoiding manipulation of RBBA. In case of the presence of persistent primitive trigeminal artery (PPTA), it is necessary to preserve the antegrade blood flow of PPTA because avoiding ischemic complications. Here, we present a case of RBBA concomitant with ipsilateral PPTA successfully treated with multistaged overlapping braided stents maintaining PPTA flow. A 30-year-old woman suffered from headache and was diagnosed RBBA of the intracranial ICA concomitant with ipsilateral PPTA. A reconstructive endovascular treatment using low-profile visualized intraluminal support (LVIS) stent was performed. However, it has recurred, and RBBA has finally been occluded after overlapping LVIS stents with coil sandwich that is not yet reported in the literature. We report the first case of overlapping LVIS stents with coil sandwich for RBBA.
- Published
- 2019
32. Stent-assisted Coil Embolization Using a Low-profile Visualized Intraluminal Support Device: Characteristics and Outcomes of the Braided Stent
- Author
-
Takahiro Fujishiro, Ryokichi Yagi, Shigeru Miyachi, Ryo Hiramatsu, Yuichiro Tsuji, Hiroyuki Ohnishi, Toshihiko Kuroiwa, Shinji Kawabata, and Noriaki Matsubara
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Medicine ,Stent ,Braided stent ,Radiology ,business ,Coil embolization - Published
- 2019
- Full Text
- View/download PDF
33. Characteristics and Treatment Results of In-hospital Acute Ischemic Stroke due to Large Vessel Occlusion Treated by Mechanical Thrombectomy
- Author
-
Gen Futamura, Shigeru Miyachi, Ryokichi Yagi, Noriaki Matsubara, Yangtae Park, Toshihiko Kuroiwa, Hiroyuki Ohnishi, Shinji Kawabata, Yuichiro Tsuji, and Ryo Hiramatsu
- Subjects
medicine.medical_specialty ,business.industry ,Treatment results ,Mechanical thrombectomy ,Internal medicine ,Ischemic stroke ,Cardiology ,Medicine ,Neurology (clinical) ,In hospital stroke ,Cardiology and Cardiovascular Medicine ,business ,Acute ischemic stroke ,Large vessel occlusion - Published
- 2019
- Full Text
- View/download PDF
34. Magnetic Resonance Imaging-Guided Thrombolysis (0.6 mg/kg) Was Beneficial for Unknown Onset Stroke Above a Certain Core Size: THAWS RCT Substudy
- Author
-
Kazunori Toyoda, Manabu Inoue, Sohei Yoshimura, Hiroshi Yamagami, Makoto Sasaki, Mayumi Fukuda-Doi, Kazumi Kimura, Koko Asakura, Kaori Miwa, Takao Kanzawa, Masafumi Ihara, Rei Kondo, Masayuki Shiozawa, Masafumi Ohtaki, Kenji Kamiyama, Ryo Itabashi, Toru Iwama, Junya Aoki, Kazuo Minematsu, Haruko Yamamoto, Masatoshi Koga, Ban Mihara, Wataru Mouri, Eisuke Furui, Yukako Yazawa, Yukiko Enomoto, Yusuke Egashira, Yusuke Yakushiji, Taizen Nakase, Ryosuke Doijiri, Yasuhiro Ito, Junichiro Suzuki, Yoshinari Nagakane, Eijiro Tanaka, Yasushi Okada, Seiji Gotoh, Shuichi Igarashi, Hideyuki Ohnishi, Hiroyuki Ohnishi, Akira Tsujino, Yohei Tateishi, Shunya Takizawa, Kazunari Homma, Yoshiaki Shiokawa, Rieko Suzuki, Nobuyuki Sakai, Kenichi Todo, Nobuyuki Ohara, Yasuhiro Hasegawa, Naoshi Sasaki, Shuji Arakawa, Masato Osaki, Tsuyoshi Inoue, Yasushi Takagi, Yasuhisa Kanematsu, Shinichi Yoshimura, Yoshikazu Uesaka, Takao Urabe, Masao Watanabe, Toshihiro Ueda, Shoichiro Sato, Toshimitsu Hamasaki, Megimi Sakakibara, Takanari Kitazono, Toshiho Ohtsuki, Wataru Shimizu, Takashi Sozu, Teruyuki Hirano, Kohsuke Kudo, Naomi Morita, Ken Kuwahara, Akira Oita, Kenta Seki, Toshihiro Ide, Takashi Okada, Hajime Ikenouchi, Hiromi Ohara, Mihoko Uotani, Kayo Murata, Shoko Kamiyoshi, Haruka Kanai, Azusa Tokunaga, and Ai Ito
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,law.invention ,Randomized controlled trial ,Fibrinolytic Agents ,law ,Internal medicine ,medicine ,Humans ,Thrombolytic Therapy ,Stroke ,Aged ,Advanced and Specialized Nursing ,Aged, 80 and over ,Core (anatomy) ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Thrombolysis ,medicine.disease ,Diffusion Magnetic Resonance Imaging ,Tissue Plasminogen Activator ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background and Purpose: We determined to identify patients with unknown onset stroke who could have favorable 90-day outcomes after low-dose thrombolysis from the THAWS (Thrombolysis for Acute Wake-Up and Unclear-Onset Strokes With Alteplase at 0.6 mg/kg) database. Methods: This was a subanalysis of an investigator-initiated, multicenter, randomized, open-label, blinded–end point trial. Patients with stroke with a time last-known-well >4.5 hours who showed a mismatch between diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery were randomly assigned (1:1) to receive alteplase at 0.6 mg/kg intravenously or standard medical treatment. The patients were dichotomized by ischemic core size or National Institutes of Health Stroke Scale score, and the effects of assigned treatments were compared in each group. The efficacy outcome was favorable outcome at 90 days, defined as a modified Rankin Scale score of 0 to 1. Results: The median DWI-Alberta Stroke Program Early CT Score (ASPECTS) was 9, and the median ischemic core volume was 2.5 mL. Both favorable outcome (47.1% versus 48.3%) and any intracranial hemorrhage (26% versus 14%) at 22 to 36 hours were comparable between the 68 thrombolyzed patients and the 58 control patients. There was a significant treatment-by-cohort interaction for favorable outcome between dichotomized patients by ASPECTS on DWI ( P =0.026) and core volume ( P =0.035). Favorable outcome was more common in the alteplase group than in the control group in patients with DWI-ASPECTS 5 to 8 (RR, 4.75 [95% CI, 1.33–30.2]), although not in patients with DWI-ASPECTS 9 to 10. Favorable outcome tended to be more common in the alteplase group than in the control group in patients with core volume >6.4 mL (RR, 6.15 [95% CI, 0.87–43.64]), although not in patients with volume ≤6.4 mL. The frequency of any intracranial hemorrhage did not differ significantly between the 2 treatment groups in any dichotomized patients. Conclusions: Patients developing unknown onset stroke with DWI-ASPECTS 5 to 8 showed favorable outcomes more commonly after low-dose thrombolysis than after standard treatment. Registration: URL: https://www.clinicaltrials.gov ; Unique Identifier: NCT02002325. URL: https://www.umin.ac.jp/ctr ; Unique Identifier: UMIN000011630.
- Published
- 2020
35. Effect of Statin Administration After Onset of Acute Ischemic Stroke With Large Vessel Occlusion: Insights From RESCUE‐Japan Registry 2
- Author
-
Kazutaka Uchida, Shinichi Yoshimura, Hirotoshi Imamura, Nobuyuki Ohara, Nobuyuki Sakai, Kanta Tanaka, Hiroshi Yamagami, Yasushi Matsumoto, Masataka Takeuchi, Takeshi Morimoto, Ryosuke Doijiri, Yukiko Enomoto, Masayuki Ezura, Norihito Fukawa, Eisuke Furui, Akira Handa, Koichi Haraguchi, Taketo Hatano, Makoto Hayase, Nagayasu Hiyama, Koji Iihara, Norio Ikeda, Keisuke Imai, Hideyuki Ishihara, Ryou Itabashi, Yuki Kamiya, Chisaku Kanbayashi, Kazumi Kimura, Kazuo Kitagawa, Yoshihiro Kiura, Junya Kobayashi, Takao Kojima, Ryuji Kondo, Naoya Kuwayama, Yuji Matsumaru, Keigo Matsumoto, Yoshihisa Matsumoto, Kazuo Minematsu, Masafumi Morimoto, Kohei Nii, Kuniaki Ogasawara, Hiroyuki Ohnishi, Hajime Ohta, Takahiro Ohta, Yasushi Okada, Toshiyuki Onda, Manabu Sakaguchi, Shigeyuki Sakamoto, Makoto Sasaki, Junichiro Satomi, Masunari Shibata, Atsushi Shindo, Norio Tanahashi, Naoki Toma, Kazunori Toyoda, Tomoyuki Tsumoto, Wataro Tsuruta, Naoyuki Uchiyama, Yoshiki Yagita, Taro Yamashita, Daisuke Yamamoto, Ikuya Yamaura, Takaaki Yamazaki, and Hiroaki Yasuda
- Subjects
Male ,medicine.medical_specialty ,acute ischemic stroke ,Statin ,medicine.drug_class ,Drug Administration Schedule ,statins ,Japan ,Internal medicine ,large vessel occlusion ,medicine ,Humans ,In patient ,cardiovascular diseases ,Registries ,Acute ischemic stroke ,Original Research ,Ischemic Stroke ,Aged ,Retrospective Studies ,business.industry ,Endovascular Procedures ,Recovery of Function ,Middle Aged ,Stroke ,Treatment ,Survival Rate ,functional outcomes ,Treatment Outcome ,Acute Disease ,Cardiology ,Cerebrovascular Disease/Stroke ,Female ,Mortality/Survival ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,business ,Large vessel occlusion - Abstract
Background Statins have been associated with reduced recurrence and better functional outcomes in patients with acute ischemic stroke. However, the effect of statins in patients with acute large vessel occlusion (LVO) is not well scrutinized. Methods and Results RESCUE (Recovery by Endovascular Salvage for Cerebral Ultra‐Acute Embolism)‐Japan Registry 2, a physician‐initiated registry, enrolled 2420 consecutive patients with acute LVO who were admitted to 46 centers across Japan within 24 hours of onset. We compared patients with and without statin use after acute LVO onset (statin group and nonstatin group, respectively) in terms of the modified Rankin scale at 90 days. We estimated that the odds ratios for the primary outcome was modified Rankin scale and we estimated the odds ratios for a 1‐scale lower modified Rankin scale adjusting for confounders. After excluding 12 patients without LVO and 9 patients without follow‐up, the mean age of 2399 patients was 75.9 years; men accounted for 55% of patients. Statins were administered to 447 (19%) patients after acute LVO onset. Patients in the statin group had more atherothrombotic cerebral infarctions (34.2% versus 12.1%, P P P P =0.02). The mortality at 90 days was lower in the statin group (4.7%) than the nonstatin group (12.5%; P P =0.02). Conclusions Statin administration after acute LVO onset is significantly associated with better functional outcome and mortality at 90 days.
- Published
- 2020
36. [A Case of Primary Mediastinal Seminoma Showing Local Increase in Residual Tumor after Chemotherapy]
- Author
-
Yuto, Hattori, Kenji, Mitsumori, Naoki, Hayata, Kenji, Nakamura, Takeshi, Takahashi, Hiroyuki, Ohnishi, and Koji, Kawai
- Subjects
Adult ,Male ,Neoplasm, Residual ,Mediastinum ,Mediastinal Neoplasms ,Seminoma ,Bleomycin ,Young Adult ,Testicular Neoplasms ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Cisplatin ,Neoplasm Recurrence, Local ,Etoposide - Abstract
A 19-year-old man with abnormal findings on his chest X ray was referred to our hospital. A chest computed tomography scan revealed a 57 mm mass in the anterior mediastinum, and percutaneous needle biopsy was performed. Histopathological diagnosis was pure seminoma. Since the serum alphafetoprotein (AFP) level was normal and no abnormal findings were noted in the testis, the patient was diagnosed with mediastinal seminoma [International Germ Cell Consensus Classification (IGCCC) goodrisk group]. After three cycles of chemotherapy with bleomycin/etoposide/cisplatin [BEP], the tumor decreased in size to 32 mm, and a fluorodeoxyglucose-positron emission tomography scan indicated negative tumor findings. After four months, the residual tumor increased in size to 40 mm without any increase in the tumor marker levels. Surgical resection was performed, and the histopathological finding was only mature teratoma. Six months after the operation, there has been no recurrence.
- Published
- 2020
37. Comparison of 3ΛH/4ΛH production cross-section via (K−, π0) reaction at J-PARC
- Author
-
Takaya Akaishi, Hidemitsu Asano, Xurong Chen, Alberto Clozza, Catalina Curceanu, Raffaele Del Grande, Carlo Guaraldo, Chengdong Han, Tadashi Hashimoto, Mihai Iliescu, Kentaro Inoue, Shigeru Ishimoto, Kenta Itahashi, Masahiko Iwasaki, Yue Ma, Rie Murayama, Marco Miliucci, Hiroyuki Noumi, Hiroyuki Ohnishi, Shinji Okada, Haruhiko Outa, Kristian Piscicchia, Yuta Sada, Atsushi Sakaguchi, Fuminori Sakuma, Masaharu Sato, Alessandro Scordo, Diana Sirghi, Florin Sirghi, Kotaro Shirotori, Shoji Suzuki, Kiyoshi Tanida, Taiga Toda, Megumu Tokuda, Masato Tsuruta, Takumi Yamaga, Xiaohua Yuan, Hongqiang Zhang, Pengming Zhang, and Yapeng Zhang
- Abstract
Recent heavy-ion collision experiments reported a surprisingly short lifetime for the hypertriton, which has been recognized as the hypertriton lifetime puzzle. Our J-PARC E73 experiment contributes to solve this puzzle with an independent experimental method by employing 3He(K−, π0) 3ΛH reaction. In this contribution, we will demonstrate our capability to provide 3ΛH binding energy information by deriving the production cross section ratio, σ3ΛH/σ4ΛH. The production cross section data for 3ΛH and 4ΛH are already available as the pilot run of E73 experiment and data analysis is in progress.
- Published
- 2022
- Full Text
- View/download PDF
38. Development of an optically pumped atomic magnetometer using a K-Rb hybrid cell and its application to magnetocardiography
- Author
-
Yosuke Ito, Hiroyuki Ohnishi, Keigo Kamada, and Tetsuo Kobayashi
- Subjects
Physics ,QC1-999 - Abstract
We have developed an optically pumped atomic magnetometer using a hybrid cell of K and Rb. The hybrid optical pumping technique can apply dense alkali-metal vapor to the sensor head and leads to high signal intensity. We use dense Rb vapor as probed atoms, and achieve a sensitivity of approximately 100 fTrms/Hz1/2 around 10 Hz. In this case, the sensitivity is limited by the system noise, and the magnetic linewidth is narrower than that for direct Rb optical pumping. We demonstrated magnetocardiography using the magnetometer and obtained clear human magnetocardiograms.
- Published
- 2012
- Full Text
- View/download PDF
39. Protection from acetaminophen-induced hepatotoxicity by post-administration of 1O, 20O-diacetyl kamebakaurin in mice
- Author
-
Naohito Ohno, Koichi Takeya, Yoshiyuki Adachi, Ming-Yu Gui, Yukio Hitotsuyanagi, Nobuhiko Miura, Hiroki Yoshioka, Xuwen Li, Yutaka Aoyagi, Hiroyuki Ohnishi, Masae Yoshikawa, and Yongri Jin
- Subjects
chemistry.chemical_compound ,chemistry ,medicine ,Kamebakaurin ,Pharmacology ,Diacetyl ,Acetaminophen ,medicine.drug - Published
- 2018
- Full Text
- View/download PDF
40. 1O, 20O-diacetyl kamebakaurin protects against acetaminophen-induced hepatotoxicity in mice
- Author
-
Yoshiyuki Adachi, Masae Yoshikawa, Hiroki Yoshioka, Nobuhiko Miura, Ming-Yu Gui, Hiroyuki Ohnishi, Yongri Jin, Naohito Ohno, Nobuyuki Fukuishi, Yutaka Aoyagi, Tsunemasa Nonogaki, Xuwen Li, Koichi Takeya, and Yukio Hitotsuyanagi
- Subjects
0301 basic medicine ,Antioxidant ,Ethanol ,Kinase ,medicine.medical_treatment ,CYP1A2 ,Chromosomal translocation ,General Medicine ,Pharmacology ,medicine.disease_cause ,General Biochemistry, Genetics and Molecular Biology ,Acetaminophen ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,Cytokine ,chemistry ,030220 oncology & carcinogenesis ,medicine ,Oxidative stress ,medicine.drug - Abstract
The present study aimed to investigate the protective effects of kamebakaurin (KA) and 1O, 20O-diacetyl kamebakaurin (Ac2KA) on acetaminophen (APAP)-induced hepatotoxicity and compare the hepatoprotective mechanisms of the two chemicals. Seven-week-old male C57BL/6J mice were orally administered KA, Ac2KA, or an ethanol/olive oil emulsion once per day for 7-days. Twenty-four hours after the final administration, the mice were fasted and then intraperitoneally injected with 450 mg/kg APAP or saline. At 16 h after injection, the mice were euthanized and blood samples were collected for plasma analysis. Pretreatment with KA and Ac2KA significantly attenuated APAP-induced hepatic injury. The protective effect of Ac2KA was stronger than that of KA. These two chemicals attenuated oxidative stress, inflammatory cytokine production, c-jun N-terminal kinase activation, and receptor-interacting protein (RIP)-3 activation. Ac2KA also decreased APAP-induced RIP-1 activation and nuclear factor kappa B (NF-κB) p65 translocation. Moreover, Ac2KA repressed mRNA expression of Cyp1a2/2e1 in the liver. Our results showed that KA and Ac2KA exerted protective effects against APAP-induced hepatotoxicity. The responsible mechanisms may be related to the chemicals' antioxidant activity and the inhibition of c-jun N-terminal kinase activation and RIP-3 activation. The effects of Ac2KA included those of KA, as well as RIP-1 inactivation, NF-κB inhibition, and Cyp inhibition.
- Published
- 2018
- Full Text
- View/download PDF
41. Effects of sacha inchi oil intake on lifestyle-related diseases in mice
- Author
-
Hiroyuki Ohnishi, Yukiko Naito, and Naoki Ohara
- Subjects
Applied Mathematics ,General Mathematics ,Oil intake ,Food science - Published
- 2018
- Full Text
- View/download PDF
42. Flow Diverter for Large Carotid Cavernous Aneurysms
- Author
-
Ryo Hiramatsu, Toshihiko Kuroiwa, Shigeru Miyachi, Hiroyuki Ohnishi, and Ryokichi Yagi
- Subjects
03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,medicine ,Radiology ,business ,030217 neurology & neurosurgery ,030218 nuclear medicine & medical imaging ,Flow diverter - Published
- 2018
- Full Text
- View/download PDF
43. TNF Type-I Receptor Inhibitor, R-7050 Attenuates Acute Kidney Injury in a Mouse Model of Crush Syndrome
- Author
-
Eriko Osaki, Hiroyuki Ohnishi, and Shinya Mizuno
- Subjects
Kidney ,biology ,Hyperkalemia ,urogenital system ,business.industry ,Acute kidney injury ,Pharmacology ,urologic and male genital diseases ,medicine.disease ,female genital diseases and pregnancy complications ,Pathogenesis ,medicine.anatomical_structure ,medicine ,biology.protein ,Tumor necrosis factor alpha ,medicine.symptom ,Crush syndrome ,Interleukin 6 ,business ,Rhabdomyolysis - Abstract
Crush syndrome (CS) is caused by severe and extensive muscular skeletal damages, and acute kidney injury (AKI) with hyperkalemia is one of the most lethal factors of this syndrome. Especially under natural disasters of earthquake, many persons die due to AKI and hyperkalemia-induced cardiac arrest, but there has been no pathogenesis-based drugs for preventing CS-induced AKI. Pro-inflammatory cytokines, such as TNF-α and IL-6, play a critical role for induction of AKI during CS development. Glycerol-injected mice are used as an experimental tool for reflecting pathological events of human CS. Using this popular model, we provide evidence to show that TNF type-I receptor (TNFR1) inhibitor, R-7050 significantly attenuates the onset of AKI after the muscular destruction. In this process, R-7050 treatment suppressed the NF-κB activation in the affected kidney, and this was associated with a decrease in blood IL-6, a downstream target of NF-κB. As a result, renal tubular apoptosis became milder in the R-7050-treated CS mice. These findings suggest that induction of IL-6 via sequential events of TNF-α a TNFR1 a NF-κB is contributable for renal tubular apoptosis, a histological hallmark of AKI. Thus, TNFR1-selective inhibition can be a pharmacological strategy to attenuate the onset of AKI immediately after the clinical manifestation of rhabdomyolysis.
- Published
- 2018
- Full Text
- View/download PDF
44. Canola oil toxicity in SHRSP and its sex difference
- Author
-
Kenjiro Tatematsu, Yukiko Naito, Naoki Ohara, Hiroyuki Ohnishi, Harumi Okuyama, Yoshiaki Saito, Daisuke Miyazawa, Yoko Hashimoto, Mai Nishikawa, and Risako Ninomiya
- Subjects
Animal science ,food.ingredient ,food ,Applied Mathematics ,General Mathematics ,Biology ,Canola ,Oil toxicity - Published
- 2018
- Full Text
- View/download PDF
45. Tied Pipeline: A Case of Rare Complication
- Author
-
Toshihiko Kuroiwa, Shigeru Miyachi, Ryokichi Yagi, Hiroyuki Ohnishi, and Ryo Hiramatsu
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Case Report ,complication ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Aneurysm ,medicine ,Humans ,cardiovascular diseases ,Endovascular treatment ,Flow diverter ,business.industry ,Endovascular Procedures ,flow diverter ,Stent ,Intracranial Aneurysm ,Middle Aged ,medicine.disease ,Embolization, Therapeutic ,Surgery ,Catheter ,surgical procedures, operative ,aneurysm ,cardiovascular system ,Female ,Stents ,Neurology (clinical) ,Complication ,business ,Carotid Artery, Internal ,030217 neurology & neurosurgery - Abstract
A 48-year-old female with a symptomatic giant carotid cavernous aneurysm underwent endovascular treatment with multiple Pipeline Flex embolic devices (PED). The delivery catheter had to take a complicated course of multiple turns to cross the aneurysm, and its loop was tied in the aneurysm. When the catheter was to be withdrawn, it was apparent that the tied catheter had made a tight knot that bound the tail of the previous PED together. We successfully retrieved all of the system including the tied PED, and we used telescoping stents with five PEDs in the next operation. Although this is a rare complication, it is worth noting and checking to make sure that there is no knot before deploying the stent.
- Published
- 2018
- Full Text
- View/download PDF
46. Catastrophic Multiple Microbleeds Caused by Infective Endocarditis Following Intravenous Thrombolysis and Endovascular Thrombectomy
- Author
-
Hiroyuki Nakase, Ichiro Nakagawa, Ryosuke Maeoka, Hideyuki Ohnishi, Kenkichi Takahashi, and Hiroyuki Ohnishi
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Brain Ischemia ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Humans ,Medicine ,Thrombolytic Therapy ,Acute ischemic stroke ,Thrombectomy ,medicine.diagnostic_test ,business.industry ,Endovascular Procedures ,Rehabilitation ,Magnetic resonance imaging ,Endocarditis, Bacterial ,Thrombolysis ,Middle Aged ,medicine.disease ,Cerebral Angiography ,Stroke ,Diffusion Magnetic Resonance Imaging ,Treatment Outcome ,Hemorrhagic complication ,Infective endocarditis ,Ischemic stroke ,Cardiology ,Surgery ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Intracranial Hemorrhages ,Magnetic Resonance Angiography ,030217 neurology & neurosurgery ,After treatment ,Large vessel occlusion - Abstract
Ischemic stroke is one of the most common complications of infective endocarditis (IE). IE must be considered as one of the causes of acute ischemic stroke (AIS) with emergent large vessel occlusion (ELVO), but early diagnosis of IE is difficult. AIS with ELVO must be treated using endovascular thrombectomy (EVT), with or without intravenous thrombolysis (IVT). IVT for AIS due to IE is not well established and remains controversial because of the risk of intracranial hemorrhage. A 42-year-old man suffered from right hemiparesis and disorientation, and AIS with ELVO was diagnosed. EVT with IVT was successfully performed and recanalization was achieved, but catastrophic multiple cerebral microbleeds appeared after treatment. EVT without IVT could be chosen for AIS caused by IE to avoid hemorrhagic complications. Hypointense signal spots on T2*-weighted magnetic resonance imaging (MRI) and susceptibility-weighted MRI could facilitate early diagnosis of IE.
- Published
- 2019
- Full Text
- View/download PDF
47. Mobile IP Route Optimization Method for a Carrier-Scale IP Network.
- Author
-
Takeshi Ihara, Hiroyuki Ohnishi, and Yasushi Takagi
- Published
- 2000
- Full Text
- View/download PDF
48. Staged strategy using a transcarotid approach for acute tandem occlusions with left common carotid artery origin steno-occlusive lesion
- Author
-
Ryosuke Maeoka, Hideyuki Ohnishi, Ichiro Nakagawa, and Hiroyuki Ohnishi
- Subjects
Acute tandem occlusion ,medicine.medical_specialty ,business.industry ,Case Report ,Intracranial Artery ,medicine.disease ,Lesion ,Stenosis ,Retrograde transcarotid approach ,medicine.artery ,Occlusion ,medicine ,Ica occlusion ,Surgery ,Neurology (clinical) ,Common carotid artery ,Radiology ,medicine.symptom ,Internal carotid artery ,Endovascular treatment ,business ,Staged strategy ,Left common carotid artery origin steno-occlusive lesions - Abstract
Background: Endovascular treatment for acute tandem occlusion (ATO) of the combination of an ipsilateral extracranial internal carotid artery (ICA) steno-occlusive lesion with concurrent intracranial artery occlusion is challenging. Whether extracranial lesions, especially in cases of the left common carotid artery (LCCA) origin steno-occlusive lesions, should be treated after recanalization of an occluded intracranial artery by mechanical thrombectomy simultaneously in the same session has not been established. We report two cases of successful ATO with LCCA origin steno-occlusive lesions treated by staged retrograde transcarotid LCCA stenting followed emergent mechanical thrombectomy in two sessions because of the tortuous aortic arch. Case Description: A 61-year-old man with left ICA occlusion and an 82-year-old woman with left middle cerebral artery occlusion underwent emergent mechanical thrombectomy for ATO with LCCA origin stenoocclusive lesions. We achieved recanalization of large vessels, but severe stenosis of LCCAs remained. Because of the tortuous aortic arch, we decided to treat LCCA origin steno-occlusive lesions with staged stenting in the other session followed emergent mechanical thrombectomy. Postoperative courses were uneventful, and their symptoms improved. We performed stenting using a transcarotid approach through CCA cut down for LCCA steno-occlusive lesions without any complications. Conclusion: The staged strategy leaving LCCA origin stenosis seems to offer a better strategy than the simultaneous strategy for ATO with LCCA origin steno-occlusive lesions. A retrograde transcarotid approach through CCA cut down is recommended for LCCA stenting.
- Published
- 2021
- Full Text
- View/download PDF
49. Usefulness of the Pipeline Embolic Device for Large and Giant Carotid Cavernous Aneurysms
- Author
-
Ryokichi Yagi, Shigeru Miyachi, Toshihiko Kuroiwa, Hiroyuki Ohnishi, and Ryo Hiramatsu
- Subjects
endovascular treatment ,medicine.medical_specialty ,Ocular motor ,Parent artery ,lcsh:RC321-571 ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Aneurysm ,Complete occlusion ,medicine ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Flow diverter ,Coil embolization ,Original Paper ,lcsh:R5-920 ,business.industry ,flow diverter ,carotid cavernous aneurysm ,medicine.disease ,Radiological weapon ,Radiology ,lcsh:Medicine (General) ,business ,Perfusion ,030217 neurology & neurosurgery ,pipeline™ embolic device - Abstract
Purpose Conventional coil embolization for large carotid cavernous aneurysms (CCAs) has limited utility due to its inability to prevent recurrences and reduce mass effect. Trapping of the parent artery may have a risk of ischemic complications due to intracranial perfusion disorders. We successfully treated 24 patients with large CCAs using a flow diverter (Pipeline™ embolic device: PED), and this report discusses the safety and efficacy of this method. Materials and methods Twenty four patients (23 females, mean age 71.5 years old) with large CCAs, including 6 giant CCAs, were treated with a PED over three years. Under sufficient dual anti-platelet management, the PED was deployed over the orifice of the aneurysm. Two patients required multiple telescoping stents. Clinical and radiological states were checked with MRI at 1, 3 and 6 months post-surgically. Angiographic follow-up was performed at 6 months. Results In all patients, PED was appropriately deployed. Stagnation of contrast with eclipse signs was observed post-angiogram in 21 cases. One patient requiring 5 telescoping stents experienced temporary ischemic symptoms. Fourteen patients experienced improvement of ocular motor impairment deficiency, including 6 patients who recovered. Angiograms at 6 months follow-up showed complete occlusion in 63% (12/19) of patients, and MRI showed reduction of aneurysm volume in 89% (17/19) of patients. Conclusion Flow diverters for large CCAs showed promising clinical and radiological efficacy. They can shrink the aneurysm and improve symptoms without sacrificing the parent artery. It will be necessary to summarize the cases and to verify the long-term results.
- Published
- 2017
- Full Text
- View/download PDF
50. Safety and Usefulness of Endovascular Treatment for Cerebral Unruptured Aneurysms in Elderly Patients: Efficacy of a Flow Diverter for Large Carotid Cavernous Aneurysms
- Author
-
Toshihiko Kuroiwa, Takashi Izumi, Shigeru Miyachi, Ryo Hiramatsu, Noriaki Matsubara, Hiroyuki Ohnishi, and Ryokichi Yagi
- Subjects
medicine.medical_specialty ,business.industry ,030218 nuclear medicine & medical imaging ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Unruptured aneurysm ,Endovascular treatment ,Complication ,Elderly patient ,business ,030217 neurology & neurosurgery ,Flow diverter - Published
- 2017
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.