Search

Your search keyword '"Hirotada IKEDA"' showing total 36 results
Start Over Author "Hirotada IKEDA"
36 results on '"Hirotada IKEDA"'

1. Trachea enhances neurite regeneration from adult rat nodose ganglia in vitro

Author

Kaori Takeshita, Kazunori Sango, Yoshiaki Ishigatsubo, Hidenori Horie, Yoshihiro Ishikawa, Hirotada Ikeda, and Haruhiro Saito

Subjects
Male, Pathology, medicine.medical_specialty, Neurite, Cell Survival, Biology, General Biochemistry, Genetics and Molecular Biology, Neurites, medicine, Animals, Rats, Wistar, General Pharmacology, Toxicology and Pharmaceutics, Cell survival, Regeneration (biology), Nodose Ganglion, General Medicine, Anatomy, Neurite regeneration, Coculture Techniques, In vitro, Nerve Regeneration, Rats, Vagus nerve, Trachea, Explant culture
Abstract

Trachea is intensely innervated with vagal afferent nerve fibers, and may play an important role in vagus nerve regeneration after axonal injury caused by trauma and surgical operation. We investigated the effects of tracheal tissue on neuronal cell survival and neurite regeneration in adult rat nodose ganglia (NG) in vitro. Co-culture with trachea significantly increased the average number of neurites regenerated from transected nerve terminals of NG explants, from 73.7 to 154.2 after 3 days, from 68 to 186.7 after 5 days, and from 31 to 101.5 after 7 days in culture. Dissociated NG neurons could continue to survive and extend neurites only in the co-existence with satellite cells in collagen gel. Co-cultured trachea improved the ratios of survival and neurite-bearing cells of NG neurons, from 56.7% and 11.1% to 72.3% and 37.6% after 4 days, and from 41.1% and 20.3% to 56.4% and 47.2% after 7 days in culture, respectively. These results imply that tracheal tissue secretes a factor, which could enhance neuronal cell survival and neurite regeneration in NG in the presence of satellite cells in vitro.

Published
2002
Full Text
View/download PDF

2. TachykininsviaTachykinin NK2receptor activation mediate ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs

Author

Takao Okubo, Li Fu, Takeshi Kaneko, Shunsuke Suzuki, Pierangelo Geppetti, Harumi Nishiyama, Marcello Trevisani, Hirotada Ikeda, and Yoshiaki Ishigatsubo

Subjects
Pharmacology, Agonist, medicine.drug_class, Chemistry, Neuropeptide, Substance P, respiratory system, Receptor antagonist, chemistry.chemical_compound, In vivo, Permeability (electromagnetism), Immunology, medicine, Neurokinin A, Receptor
Abstract

1. Acute exposure to ozone is known to cause airway hyperresponsiveness, which, at least in part, seems to result from an increase in the permeability of the airway mucosa. Recently, we demonstrated that depletion of sensory neuropeptides inhibits the ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs. The aim of this study was to determine whether tachykinins mediate ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs. 2. Anaesthetized guinea-pigs were exposed to either 3 p.p.m. ozone or filtered air for 30 min. Immediately after exposure, a tracheal segment was isolated in vivo and administered with horseradish peroxidase (HRP). The permeability was assessed by monitoring the appearance of HRP in the blood. 3. A low dose of NKA increased the permeability of the tracheal mucosa, whereas a low dose of SP was without effect. Low and high doses of the selective NK(3) receptor agonist, senktide, were also without effect. The effect of a low dose of NKA was abolished by the NK(2) receptor antagonist, SR-48,968. A high dose of SP increased the permeability in a manner reversible by the NK(1) receptor antagonist, CP-96,345. 4. Pretreatment with SR-48,968 completely inhibited the ozone-induced increase in the permeability, whereas CP-96,345 had no effect. 5. It is thus concluded that endogenous tachykinins mediate the ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs mainly via NK(2) receptor activation.

Published
2002
Full Text
View/download PDF

3. Enhanced neural regeneration from transected vagus nerve terminals in diabetic mice in vitro

Author

Hidenori Horie, Shuji Inoue, Kazunori Sango, Haruhiro Saito, Yoshiaki Ishigatsubo, Hirotada Ikeda, and Yoshihiro Ishikawa

Subjects
medicine.medical_specialty, Neurite, medicine.medical_treatment, Diabetes Mellitus, Experimental, Mice, Reference Values, Diabetes mellitus, Internal medicine, Neurites, medicine, Animals, Nerve Endings, Denervation, business.industry, General Neuroscience, Regeneration (biology), Vagus Nerve, Nodose Ganglion, medicine.disease, Nerve Regeneration, Vagus nerve, Mice, Inbred C57BL, Endocrinology, Female, Axotomy, business, Neuroscience, Free nerve ending
Abstract

This study examined the effect of diabetes on neural regeneration in vitro. Nodose ganglia (NG) with vagal nerve fibers, dissected from streptozotocin-induced diabetic and normal C57BL/6J mice were embedded in collagen gel. After 3 and 7 days in culture, the numbers of regenerating neurites from transected nerve terminals of NG in diabetic mice were significantly greater than those in controls. Although many studies have revealed diabetes-associated impairment in neural regeneration, the results in the present study suggest that experimental diabetes could induce the potential to enhance regenerative capability of vagal sensory nerves after axotomy.

Published
1999
Full Text
View/download PDF

4. Mucosa-Associated Lymphoid Tissue Lymphoma of the Lung

Author

Takao Okubo, Nobumasa Kakemizu, Masanori Nishikawa, Yohei Miyagi, Heiwa Kanamori, Naomi Kawano, Yukio Nakatani, Takeshi Kaneko, and Hirotada Ikeda

Subjects
Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Lung, business.industry, Mucosa-Associated Lymphoid Tissue Lymphoma, Transbronchial lung biopsy, B-cell proliferation, law.invention, medicine.anatomical_structure, law, Monoclonal, Medicine, business, Polymerase chain reaction
Published
1998
Full Text
View/download PDF

5. Use of a Bipolar Polypectomy Snare through a Flexible Bronchoscope for Partial Resection of Polypoid Tumor in Patients with Obstructing Bronchogenic Carcinomas

Author

Tadashi Akahori, Takao Okubo, Jun Tsukiji, Kyota Iijima, Koichiro Misuta, Nobumasa Kakemizu, Mitsuo Matsuoka, Hidenori Tajima, Hirotada Ikeda, Takao Moroboshi, and Masanori Nishikawa

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, medicine, In patient, Partial resection, business, Flexible bronchoscopy, Polypectomy snare, Surgery
Published
1997
Full Text
View/download PDF

6. A Case of Diffuse Malignant Pleural Mesothelioma which Responded Remarkably to Cisplatin-based Combination Chemotherapy and Thermoradiotherapy

Author

Hirotada Ikeda, Masanori Nishikawa, Hitoshi Kitamura, Yukio Nakatani, Takao Okubo, and Yutaka Matsumoto

Subjects
Pulmonary and Respiratory Medicine, Oncology, Cisplatin, medicine.medical_specialty, business.industry, Pleural mesothelioma, Internal medicine, medicine, Combination chemotherapy, business, medicine.drug
Abstract

症例は49歳, 男性.呼吸困難, 胸痛, 気胸で発症.8ヵ月後, 呼吸困難と咳漱の増悪を主訴に当科を初診.胸部単純写真にて右胸壁腫瘤を認め, 経皮的腫瘍生検にて混合型びまん性悪性胸膜中皮腫と診断した.Cisplatinを主体とした多剤併用化学療法を5クール施行後, 温熱併用放射線療法を追加し, 著明な腫瘍縮小効果を認めた.自覚症状出現後2年5ヵ月, 治療開始後1年8ヵ月の現在, 生存中である.びまん性悪性胸膜中皮腫の予後は一般に不良であるが, 化学療法や温熱併用放射線療法などを組み合わた治療が有効である可能性が示唆された.

Published
1996
Full Text
View/download PDF

7. Platelet-activating factor mediates the ozone-induced increase in airway microvascular leakage in guinea pigs

Author

Takeshi Kaneko, Hirotada Ikeda, Takao Okubo, Harumi Nishiyama, and Li Fu

Subjects
Male, medicine.drug_class, Guinea Pigs, Respiratory System, Bronchi, Receptors, Cell Surface, Platelet Membrane Glycoproteins, In Vitro Techniques, Pharmacology, Toxicology, Receptors, G-Protein-Coupled, Microcirculation, Capillary Permeability, Guinea pig, chemistry.chemical_compound, Ozone, medicine, Animals, Platelet Activating Factor, Evans Blue, Dose-Response Relationship, Drug, Platelet-activating factor, business.industry, Azepines, Triazoles, respiratory system, Receptor antagonist, Pollution, Extravasation, Trachea, medicine.anatomical_structure, Mechanism of action, chemistry, Immunology, Respiratory Physiological Phenomena, Inflammation Mediators, medicine.symptom, business, Respiratory tract
Abstract

In the present study, we asked whether platelet-activating factor (PAF) mediates the ozone-induced increase in airway microvascular leakage. To answer this question, we examined the effect of a PAF receptor antagonist on the ozone-induced increase in airway microvascular leakage quantified by the extravasation of Evans blue dye in the guinea pig trachea and main bronchi. Guinea pigs were pretreated with the PAF receptor antagonist, E6123 (( S )-(+)-6-(2-chlorophenyl)-3-cyclopropane-carbonyl-8,11- dimethyl-2,3,4,5-tetrahydro-8 H -pyrido[4′,3′:4,5]thieno[3,2- f ][1,2,4]triazolo[4,3- a ][1,4]diazepine) (0.01, 0.1 and 1.0 mg/kg i.v.) and then exposed to 3 ppm ozone for 30 min. The PAF receptor antagonist significantly reduced the ozone-induced increase in microvascular leakage in a dose-dependent manner in both the trachea and main bronchi. Our results indicate that PAF mediates the ozone-induced increase in airway microvascular leakage. We therefore suggest that PAF may be involved in ozone-induced airway inflammation.

Published
1995
Full Text
View/download PDF

8. Dose‐response relationship of ozone‐induced airway hyperresponsiveness in unanesthetized guinea pigs

Author

Takao Okubo, Hirotada Ikeda, Tsutomu Fukuda, Masanori Nishikawa, Shunsuke Suzuki, and Junnichi Suzuki

Subjects
medicine.medical_specialty, Time Factors, Ozone, Guinea Pigs, Respiratory System, Toxicology, chemistry.chemical_compound, Internal medicine, medicine, Animals, Methacholine Compounds, Respiratory system, Specific Airway Resistance, Methacholine Chloride, Aerosols, Air Pollutants, Dose-Response Relationship, Drug, Airway Resistance, respiratory system, Pollution, Dose–response relationship, Endocrinology, medicine.anatomical_structure, chemistry, Anesthesia, Toxicity, Respiratory Physiological Phenomena, Breathing, Female, Methacholine, Respiratory tract, medicine.drug
Abstract

The effect of ozone dose (the product of ozone concentration and exposure time) on airway responsiveness was examined in unanesthetized, spontaneously breathing guinea pigs. Airway responsiveness was assessed by measuring specific airway resistance (sRaw) as a function of increasing concentration of inhaled methacholine (Mch) aerosol (the concentration of Mch required in order to double the baseline sRaw: PC200Mch). The airway responsiveness was measured before and at 5 min, 5 h, and 24 h after exposure. A 30-min exposure to 1 ppm ozone (dose 30 ppm.min) did not change PC200Mch at any time after exposure. Both a 90-min exposure to 1 ppm ozone and a 30-min exposure to 3 ppm ozone, which are identical in terms of ozone dose (90 ppm.min), decreased PC200Mch to a similar degree. A 120-min exposure to 3 ppm ozone (360 ppm.min) produced a much greater decrease of PC200Mch at 5 min and 5 h after exposure, compared with low-dose exposure. There was a significant correlation between ozone dose and the change in airway responsiveness. In all groups, the baseline sRaw was increased by approximately 50% at 5 min after exposure, but there was no correlation between the changes in PC200Mch and the baseline sRaw. This study suggests that ozone-induced airway hyperresponsiveness in guinea pigs is closely related to ozone dose.

Published
1990
Full Text
View/download PDF

9. Acute respiratory failure due to military tuberculosis in a patient with idiopathic CD4+ T-lymphocytopaenia

Author

Y. Matsumoto, M. Numata, Yuzo Suzuki, Hirotada Ikeda, J. Suzuki, T. Okubo, and Sayaka Suzuki

Subjects
Male, Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Tuberculosis, Antitubercular Agents, Immunopathology, medicine, Humans, T-Lymphocytopenia, Idiopathic CD4-Positive, Intensive care medicine, Leukopenia, Lung, Tuberculosis, Miliary, business.industry, Respiratory disease, Middle Aged, medicine.disease, medicine.anatomical_structure, Respiratory failure, Acute Disease, Lymphocytopenia, medicine.symptom, Respiratory Insufficiency, business, Complication
Published
1998
Full Text
View/download PDF

10. Large cell carcinoma of the lung metastatic to nuchal muscle

Author

Takao Okubo, Tadashi Akahori, Seiko Kimura, Hirotada Ikeda, Masanori Nishikawa, Nobumasa Kakemizu, Yukio Nakatani, and Hitoshi Kuriyama

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Pathology, Lung Neoplasms, Sensitivity and Specificity, Neck Muscles, medicine, Carcinoma, Humans, Lung cancer, Aged, Muscle Neoplasms, Lung, Percutaneous needle biopsy, medicine.diagnostic_test, business.industry, Large cell, Biopsy, Needle, Skeletal muscle, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Large-cell lung carcinoma, Carcinoma, Large Cell, Radiology, Tomography, X-Ray Computed, business
Abstract

Clinically apparent hematogenous skeletal muscle metastases from lung cancer are extremely rare. We present a 72-year-old man with a large cell lung carcinoma metastatic to nuchal muscle. Cervical computed tomography (CT) and magnetic resonance imaging (MRI) revealed the presence of a well-defined mass in the left splenius capitis muscle. A percutaneous needle biopsy was performed to establish a diagnosis. Localized skeletal muscle swelling may rarely prove to be metastases in patients with lung cancer, but should be investigated in the case of muscle swelling.

Published
1997
Full Text
View/download PDF

11. Long-term induction of beta-CGRP mRNA in rat lungs by allergic inflammation

Author

Eri Hagiwara, Takao Okubo, Takaaki Ito, Hirotada Ikeda, Kazunori Sango, Hitoshi Kitamura, Yoshiaki Ishigatsubo, Haruhiro Saito, Shuji Inoue, Naoko Udaka, Hidenori Horie, Haruaki Kageyama, and Jun Tsukiji

Subjects
Gene isoform, Male, medicine.medical_specialty, Time Factors, Calcitonin Gene-Related Peptide, Neuropeptide, Calcitonin gene-related peptide, Biology, General Biochemistry, Genetics and Molecular Biology, Allergic inflammation, Internal medicine, Ganglia, Spinal, Rats, Inbred BN, medicine, Respiratory Hypersensitivity, Animals, RNA, Messenger, General Pharmacology, Toxicology and Pharmaceutics, Lung, Inflammation, Reverse Transcriptase Polymerase Chain Reaction, General Medicine, Allergens, Immunohistochemistry, Rats, Ovalbumin, Disease Models, Animal, medicine.anatomical_structure, Endocrinology, Calcitonin, biology.protein, Nodose Ganglion
Abstract

Calcitonin gene-related peptide (CGRP) is one of the major neuropeptides released from sensory nerve endings and neuroendocrine cells of the lung. Two CGRP isoforms, alpha-and beta-CGRP, have been identified in rats and humans, but no studies have attempted to reveal direct evidence of differences in action or location of these isoforms in allergic inflammation (AI). We investigated mRNA expressions of alpha-and beta-CGRP in lungs, nodose ganglia (NG), and dorsal root ganglia (DRG) of an animal model for AI of the airways, utilizing a model created by sensitizing Brown Norway (BN) rats with ovalbumin (OVA). By semiquantitative RT-PCR analysis, long-lasting enhanced expression of the beta-CGRP mRNA was shown in the lungs of the AI rats (14.5-fold enhancement at 6 hr, 8.1-fold at 24 hr, and 3.7-fold at 120 hr after OVA-challenge compared to the level in the lungs of phosphate-buffered saline (PBS)-challenged control rats). In contrast, the mRNA expression of the alpha-CGRP in AI lungs showed only a transient increase after OVA-challenge (2.7-fold at 6 hr) followed by a lower level of expression (0.5-fold at 48 hr and 0.6-fold at 120 hr). The mRNA expressions of both isoforms in NG, but not in DRG, were transiently up-regulated at 6 hr after antigen challenge. In situ RT-PCR in combination with immunohistochemical analysis revealed that beta-CGRP was expressed in neuroendocrine cells in clusters (termed neuroepithelial bodies [NEBs]) in AI lungs. These results indicate that the long-term induction of beta-CGRP in NEBs may play an important role in pulmonary AI such as bronchial asthma.

Published
2004

12. Tachykinins via Tachykinin NK(2) receptor activation mediate ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs

Author

Li, Fu, Takeshi, Kaneko, Hirotada, Ikeda, Harumi, Nishiyama, Shunsuke, Suzuki, Takao, Okubo, Marcello, Trevisani, Pierangelo, Geppetti, and Yoshiaki, Ishigatsubo

Subjects
Male, Trachea, Mucous Membrane, Ozone, Neurokinin-1 Receptor Antagonists, Guinea Pigs, Papers, Animals, Receptors, Neurokinin-3, Receptors, Neurokinin-2, respiratory system, Receptors, Neurokinin-1, Permeability
Abstract

1. Acute exposure to ozone is known to cause airway hyperresponsiveness, which, at least in part, seems to result from an increase in the permeability of the airway mucosa. Recently, we demonstrated that depletion of sensory neuropeptides inhibits the ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs. The aim of this study was to determine whether tachykinins mediate ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs. 2. Anaesthetized guinea-pigs were exposed to either 3 p.p.m. ozone or filtered air for 30 min. Immediately after exposure, a tracheal segment was isolated in vivo and administered with horseradish peroxidase (HRP). The permeability was assessed by monitoring the appearance of HRP in the blood. 3. A low dose of NKA increased the permeability of the tracheal mucosa, whereas a low dose of SP was without effect. Low and high doses of the selective NK(3) receptor agonist, senktide, were also without effect. The effect of a low dose of NKA was abolished by the NK(2) receptor antagonist, SR-48,968. A high dose of SP increased the permeability in a manner reversible by the NK(1) receptor antagonist, CP-96,345. 4. Pretreatment with SR-48,968 completely inhibited the ozone-induced increase in the permeability, whereas CP-96,345 had no effect. 5. It is thus concluded that endogenous tachykinins mediate the ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs mainly via NK(2) receptor activation.

Published
2002

13. Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airways through nuclear factor-kappaB activation and IL-8 mRNA expression in guinea pigs in vivo

Author

Naoko Udaka, Takaaki Ito, Takao Okubo, Makoto Kudo, Masanori Nishikawa, Takeshi Kaneko, Hirotada Ikeda, Motoyoshi Suzuki, and Nobumasa Kakemizu

Subjects
Pulmonary and Respiratory Medicine, Male, Neutrophils, Clinical Biochemistry, Guinea Pigs, Molecular Sequence Data, Superoxide dismutase, chemistry.chemical_compound, Cell Movement, Superoxides, Smoke, medicine, Animals, Interleukin 8, RNA, Messenger, Molecular Biology, medicine.diagnostic_test, biology, Base Sequence, Superoxide, Reverse Transcriptase Polymerase Chain Reaction, Superoxide Dismutase, Interleukin-8, NF-kappa B, Cell Biology, respiratory system, medicine.disease, Molecular biology, Immunohistochemistry, Recombinant Proteins, Trachea, Bronchoalveolar lavage, chemistry, Myeloperoxidase, Immunology, Alveolar macrophage, biology.protein, Respiratory epithelium, Infiltration (medical)
Abstract

We examined the hypothesis that superoxide mediates infiltration of neutrophils to the airways through nuclear factor (NF)-kappaB and interleukin-8 (IL-8) after acute exposure to cigarette smoke (CS) in vivo. Male Hartley strain guinea pigs were exposed to air or 20 puffs of CS and killed 5 h after the exposure. The differential cell count of bronchoalveolar lavage fluid and specific myeloperoxidase enzyme assay demonstrated that acute exposure to CS caused neutrophil accumulation to the airways and parenchyma, respectively. Acute exposure to CS increased DNA-binding activity of NF-kappaB in the lung. Acute exposure to CS also increased IL-8 messenger RNA (mRNA) expression in the lung. Pretreatment of guinea pigs with recombinant human superoxide dismutase (rhSOD) aerosols reduced the CS-induced neutrophil accumulation to the airways. Both activation of NF-kappaB and increased IL-8 mRNA expression were also inhibited by the pretreatment of rhSOD aerosols. Strong immunoreactivities for p65 and p50 were detected in the nuclei of alveolar macrophages after acute exposure to CS. The signal for IL-8 mRNA expression was demonstrated in the alveolar space after acute exposure to CS. Neither significant immunoreactivities for p65 and p50 nor IL-8 mRNA signals were observed in airway epithelium. These observations suggest that acute exposure to CS initiates superoxide-dependent mechanism that, through NF-kappaB activation and IL-8 mRNA expression, produces infiltration of neutrophils to the airways in vivo. It was also suggested that the alveolar macrophage is one potential source of NF-kappaB activation and IL-8 mRNA expression after acute exposure to CS.

Published
1999

14. Neuropeptides mediate the ozone-induced increase in the permeability of the tracheal mucosa in guinea pigs

Author

Hirotada Ikeda, Li Fu, Takao Okubo, Takeshi Kaneko, Harumi Nishiyama, Takaaki Ito, and Makoto Kudo

Subjects
Pulmonary and Respiratory Medicine, Atropine, Male, Physiology, Guinea Pigs, Neuropeptide, Propranolol, Pharmacology, Horseradish peroxidase, Models, Biological, Permeability, Guinea pig, chemistry.chemical_compound, Ozone, In vivo, Physiology (medical), Neural Pathways, medicine, Animals, Respiratory system, Horseradish Peroxidase, Mucous Membrane, biology, Chemistry, Neuropeptides, Cell Biology, Trachea, Capsaicin, Anesthesia, biology.protein, Microscopy, Electron, Scanning, medicine.drug
Abstract

We examined the effects of acute exposure to ozone on the permeability of the tracheal mucosa and the contribution of neural pathways to the effects of ozone using horseradish peroxidase (HRP; mol wt 40,000) as a marker of lumen-to-blood transfer of a macromolecule in guinea pigs in vivo. Each guinea pig was anesthetized and exposed for 30 min to either ozone [0.5 or 3 parts/million (ppm)] or air. Immediately after exposure, a tracheal segment was isolated between two polyethylene cannulas in vivo and filled with HRP solution (50 mg/ml). Blood samples were drawn before and 10, 20, 30, and 40 min after the intratracheal instillation of HRP. The plasma levels of HRP in guinea pigs exposed for 30 min to 3 ppm of ozone, but not to 0.5 ppm of ozone, were significantly greater than those in guinea pigs exposed to air. Although the increased plasma HRP levels after exposure to 3 ppm of ozone were unaffected by propranolol or atropine, they were completely inhibited by pretreatment with capsaicin (50 mg/kg sc, injected in two doses). These results suggest that endogenous neuropeptides mediate the ozone-induced increase in the permeability of the tracheal mucosa in guinea pigs in vivo, but neither an adrenergic nor a cholinergic pathway appears to be involved.

Published
1998

15. Role of superoxide anions in airway hyperresponsiveness induced by cigarette smoke in conscious guinea pigs

Author

Takao Okubo, Hirotada Ikeda, Makoto Kudo, Masanori Nishikawa, and Nobumasa Kakemizu

Subjects
Male, Pulmonary and Respiratory Medicine, Bronchoconstriction, Guinea Pigs, Pharmacology, Bronchial Provocation Tests, Bronchoconstrictor Agents, Superoxide dismutase, chemistry.chemical_compound, Superoxides, Administration, Inhalation, medicine, Animals, Enzyme Inhibitors, Specific Airway Resistance, Methacholine Chloride, Aerosols, chemistry.chemical_classification, Phagocytes, Reactive oxygen species, NADPH oxidase, biology, Superoxide Dismutase, Superoxide, Smoking, Acetophenones, Free Radical Scavengers, respiratory system, chemistry, Immunology, Apocynin, biology.protein, Methacholine, Bronchial Hyperreactivity, medicine.symptom, Injections, Intraperitoneal, medicine.drug
Abstract

To investigate the involvement of superoxide in airway hyperresponsiveness and bronchoconstriction induced by cigarette smoke (CS), we evaluated the effects of superoxide dismutase (SOD), a scavenger of superoxide anion, and apocynin, an inhibitor of superoxide anion-generating NADPH oxidase in phagocytes, on the airway responses induced by CS in conscious guinea pigs. Airway responsiveness was assessed by PC2OOMch, the concentration required to produce a doubling in the baseline specific airway resistance (sRaw) to an inhaled methacholine aerosol, in nonanesthetized spontaneously breathing animals. Before being exposed to ten puffs of CS, animals inhaled either SOD (5,000 units/ml or 25,000 units/ml) or vehicle. Although SOD did not affect PC2OOMch, in the air control group, this agent significantly reduced the CS-induced airway hyperresponsiveness. Repeated administration of apocynin (12 mg/kg for 4 days) did not affect PC2OOMch, after exposure to CS. These data suggest that the superoxide from CS was involved in the airway hyperresponsiveness induced by CS, whereas phagocytic reactive oxygen species were not. The data also suggest a potential therapeutic role for antioxidants in airway hyperresponsiveness.

Published
1996
Full Text
View/download PDF

16. Involvement of superoxide anions in ozone-induced airway hyperresponsiveness in unanesthetized guinea pigs

Author

Takao Okubo, Hirotada Ikeda, Makoto Kudo, and Masanori Nishikawa

Subjects
Pharmacology, NADPH oxidase, biology, Chemistry, Superoxide, Health, Toxicology and Mutagenesis, Stimulation, General Medicine, respiratory system, Toxicology, Superoxide dismutase, chemistry.chemical_compound, Immunology, Apocynin, medicine, biology.protein, Methacholine, Specific Airway Resistance, Airway, medicine.drug
Abstract

To evaluate the involvement of superoxide in ozone (O(3))-induced airway hyperresponsiveness, we studied the effects of superoxide dismutase (SOD), a scavenger of superoxide anion, and apocynin, an inhibitor of superoxide anion-generating NADPH oxidase in phagocytes, on the airway responses induced by O(3) in unanesthetized guinea pigs. Airway responsiveness was measured by PC(200)Mch, the concentration required to produce a doubling in the baseline specific airway resistance to an inhaled methacholine aerosol, in spontaneously breathing animals. Before exposure to 3 ppm O(3) for 30 min, animals inhaled either SOD (5000 U/ml) or vehicle for 5 min. Although SOD did not affect PC(200)Mch in the air control group, this agent reduced the O(3)-induced airway hyperresponsiveness. Repeated administration of apocynin (12 mg/kg for 4 days) also attenuated the O(3)-induced airway hyperresponsiveness. These data suggest that superoxide may be involved in the pathogenesis of O(3)-induced airway hyperresponsiveness, possibly through the stimulation of superoxide anions release from bronchoalveolar phagocytes. The data also suggest a potential therapeutic role for antioxidants in oxidant injury by air pollutants.

Published
1996

17. [Study on azithromycin in treatment of diffuse panbronchiolitis]

Author

Hiroyuki KOBAYASHI, Hiroaki TAKEDA, Susumu SAKAYORI, Yoshikazu KAWAKAMI, Yoshinori OTSUKA, Masashi TAMURA, Kazuki KONISHI, Shinichi TANIMOTO, Motonori FUKAKUSA, Kaoru SHIMADA, Yasuyuki SANO, Yasuo ARAI, Harumi SHISHIDO, Hisashi WATANABE, Eriko SAKAMOTO, Koichiro NAKATA, Tatsuo NAKATANI, Nagayasu TSUBOI, Shigeki ODAGIRI, Kaneo SUZUKI, Yasuhiro YOSHIIKE, Yoshihiro HIRAI, Takao OKUBO, Hirotada IKEDA, Masaaki ARAKAWA, Kouichi WADA, Hiroki TSUKADA, Atsuhiko SATO, Kingo CHIDA, Nobuhiro NARITA, Masayoshi SAWAKI, Keiichi MIKASA, Rinzo SOEJIMA, Yoshihito NIKI, Niro OKIMOTO, Takao SASAKI, Yukio MATSUMOTO, Yuji SUGIMOTO, Masamitsu KIDO, Yoshihiko NIKAIDO, Kikuo ARAKAWA, Kenji KOHNO, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Yoshinari KITAHARA, Kohei HARA, Shigeru KOHNO, Junichi KADOTA, Masaru NASU, Yoichiro GOTO, Tohru YAMASAKI, Atsushi SAITO, Hiroshi FUKUHARA, and Jun INADOME

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, medicine.drug_class, Antibiotics, Erythromycin, Azithromycin, Gastroenterology, Drug Administration Schedule, Japan, Clarithromycin, Internal medicine, medicine, Humans, Aged, business.industry, Stomach, General Medicine, Bacterial Infections, Middle Aged, medicine.disease, Rash, medicine.anatomical_structure, Sputum, Bronchiolitis, Female, medicine.symptom, business, Diffuse panbronchiolitis, medicine.drug
Abstract

In the treatment of diffuse panbronchiolitis, azithromycin (AZM), a new macrolide antibiotic with 15-membered lactone ring, was studied for its efficacy and safety. AZM, 250 mg, was intermittently administered to a total of 60 patients twice a weeks, for 3 months as a rule, and its efficacy was clinically evaluated in 52 patients and the safety in 55. The rate of efficacy was 84.6% (44/52). Clinical findings 12 weeks after the start of administration showed a decrease in sputum volume in 30 of 46 patients and amelioration of dyspnea on exertion in 23 of 46 patients, and no worsening of symptoms was observed in the patients. Vital capacity (4/22), FEV1.0 (6/21), cold agglutination reaction (22/28), and CRP (16/36) were also improved. The rate of eradication of organisms isolated from the sputum except for indigenous organisms was 39.5% (15/38); 4 of the 22 strains of Pseudomonas aeruginosa were eradicated. Adverse reactions were observed in 4 of the 55 patients (7.3%), 1 patient each with rash, itching, diarrhea, and a gastric symptom (heavy feeling in the stomach). 4 of the 54 patients (7.4%) exhibited abnormal changes in clinical laboratory test values values. These were an increase in eosinophil count in 2, elevation of GOT in 1, and elevation of Al-P in 1. These adverse reactions and abnormal changes in laboratory tests were mild or moderate. Therefore, long-term intermittent administration of AZM, twice a week, is expected to have the same effect in the treatment of diffuse panbronchiolitis as long-term small-dose administration of 14-membered macrolides such as erythromycin and clarithromycin, whose effects have already been established.

Published
1995

18. Capsaicin reduces ozone-induced airway inflammation in guinea pigs

Author

Takao Okubo, Hiro-O. Yamakawa, Li Fu, Hirotada Ikeda, Harumi Nishiyama, Mitsuo Matsuoka, and Takeshi Kaneko

Subjects
Pulmonary and Respiratory Medicine, Atropine, Male, Time Factors, Guinea Pigs, Neuropeptide, Inflammation, Vascular permeability, Bronchi, Pharmacology, Critical Care and Intensive Care Medicine, Capillary Permeability, Parasympathetic nervous system, chemistry.chemical_compound, Ozone, Medicine, Animals, Drug Interactions, Bronchitis, Analysis of Variance, business.industry, respiratory system, Propranolol, respiratory tract diseases, Capillaries, medicine.anatomical_structure, chemistry, Capsaicin, Anesthesia, Cholinergic, Axon reflex, medicine.symptom, Airway, business, Evans Blue
Abstract

We investigated whether neural pathways are involved in mediating ozone (O3)-induced airway inflammation. To determine this, we studied the contribution of adrenergic and cholinergic pathways to the O3-induced increase in airway vascular permeability, an indicator of airway inflammation, by measuring vascular permeability after giving guinea pigs propranolol or atropine to block these pathways. We also studied the contribution to O3-induced airway inflammation of neuropeptides localized in unmyelinated airway sensory nerves, by measuring vascular permeability after giving capsaicin to deplete neuropeptides from these nerves. We found that capsaicin reduced but did not abolish the increase in airway vascular permeability induced by 3 ppm O3 for 30 min. Propranolol and atropine had no effect on airway vascular permeability. These results indicate that neuropeptides released from sensory nerves, presumably by acting through the axon reflex, partly mediate O3-induced airway inflammation, and that adrenergic and cholinergic pathways are not involved.

Published
1994

19. Combined effects of ozone and cigarette smoke on airway responsiveness and vascular permeability in guinea pigs

Author

Shunsuke Suzuki, Masanori Nishikawa, H. Yamakawa, Takao Okubo, Hirotada Ikeda, and Harumi Nishiyama

Subjects
Pulmonary and Respiratory Medicine, Guinea Pigs, Bronchi, Vascular permeability, Pharmacology, Capillary Permeability, Guinea pig, chemistry.chemical_compound, Ozone, medicine, Animals, Specific Airway Resistance, Evans Blue, Dose-Response Relationship, Drug, business.industry, Airway Resistance, Parallel study, respiratory system, Extravasation, respiratory tract diseases, Trachea, Dose–response relationship, chemistry, Anesthesia, Female, Tobacco Smoke Pollution, Methacholine, Bronchial Hyperreactivity, business, medicine.drug
Abstract

The effects of combined exposure to ozone and cigarette smoke on airway responsiveness and tracheal vascular permeability, compared with those of single exposure were examined in guinea pigs. Airway responsiveness was assessed by measuring the specific airway resistance (sRaw) as a function of increasing concentration of inhaled methacholine aerosol immediately, 5 hr, and 24 hr after exposure. In a parallel study, tracheal vascular permeability was quantified by measuring the tracheal extravasation of intravenously administered Evans blue dye. Neither exposure to 1 ppm ozone for 30 min nor 5 puffs of cigarette smoke increased airway responsiveness or vascular permeability at any time after exposure. Combined exposure to 1 ppm ozone for 30 min and 5 puffs of cigarette smoke caused airway hyper-responsiveness and increased vascular permeability immediately after exposure. Exposure to 1 ppm ozone for 90 min increased both airway responsiveness and vascular permeability immediately after exposure. Exposure to 10 puffs of cigarette smoke increased airway responsiveness but not vascular permeability immediately after exposure. Combined exposure to 1 ppm ozone for 90 min and 10 puffs of cigarette smoke increased both airway responsiveness and vascular permeability immediately after exposure. The combined exposure to ozone and cigarette smoke thus increased both airway responsiveness and tracheal vascular permeability to a greater extent than did exposure to a single agent, suggesting that a combination of air pollutants has a more deleterious effect both on airway responsiveness and on tracheal vascular permeability than does either agent alone in guinea pigs.

Published
1992
Full Text
View/download PDF

20. [A comparative study of cefepime for bacterial pneumonia]

Author

Atsushi SAITO, Yoshiteru SHIGENO, Yuei IRABU, Hiroshi FUKUHARA, Soukichi ONODERA, Hitoshi NAKANO, Tetsuo SHIMIZU, Nobuhiro SASAKI, Hirotaka HASHIZUME, Yuka FUJITA, Takashi HIROSHIMA, Eiichi SAKAI, Akira SAITO, Ichiro NAKAYAMA, Yohmei HIRAGA, Mitsuhide OHMICHI, Kazuo TAKEBA, Ken OSONOI, Miyoko SAITO, Hirohisa KURODA, Masao TAMURA, Kazuki KONISHI, Yoshiaki MORI, Akiho OBARA, Kazuo OBARA, Hitoshi KOBAYASHI, Junichi OGAWA, Kunio KUDO, Munehiko ISHII, Masakichi MOTOMIYA, Akira WATANABE, Yoshihiro HONDA, Yutaka TOKUE, Mitsunobu HONMA, Masataka KATSU, Keisuke KUGA, Junzaburou KABE, Hitoshi ARIOKA, Hiroko ARIOKA, Masaru KOYAMA, Kouichiro NAKATA, Yoshitaka NAKAMORI, Osamu SAKAI, Jingorou SHIMADA, Kohya SHIBA, Masaki YOSHIDA, Hiroichi TANIMOTO, Tetsuo OKAMURA, Hiroyuki KOBAYASHI, Toru SAKAYORI, Hiroshi OSHITANI, Hiroaki TAKEDA, Shoichiro IRIMAJIRI, Yasuo MATSUOKA, Mitsuo OBANA, Takao OKUBO, Hirotada IKEDA, Fumio MATSUMOTO, Iwao SAKURAI, Takayuki TAKAHASHI, Shigeki ODAGIRI, Hiroshi TAKAHASHI, Kenichi TAKAHASHI, Yasutsugu AMANO, Takashi SAKUMA, Masaaki ARAKAWA, Koichi WADA, Takashi KAWASHIMA, Masanaga TAKATO, Shigeyuki HOSHINO, Osamu SEKINE, Yasutoshi SUZUKI, Toshihiko TAKEUCHI, Yoshimitsu HAYASHI, Kazuhide YAMAMOTO, Toshihiko YAMAMOTO, Kanzo SUZUKI, Toru MATSUURA, Satoru ADACHI, Fumiyuki KUZE, Takako MURAYAMA, Nobuo INABA, Yoshio ODA, Akira KAGIOKA, Fumio MIKI, Rinzo SOEJIMA, Yoshihito NIKI, Jiro HINO, Masaru SUMI, Toshiharu MATSUSHIMA, Masayoshi KAWANISHI, Makoto KIMURA, Shunkichi HIRAKI, Yohichi WATANABE, Masashi ARAKI, Takao SASAKI, Yukio MATSUMOTO, Yuji SUGIMOTO, Hidemi TERAMOTO, Michiro YAMAKIDO, Kenji HASEGAWA, Takashi TSUYA, Kenichiro SADAMOTO, Masao KUWABARA, Masanobu OKADA, Kenichi ARITA, Masao DOI, Kazuhiro DAIDO, Jitsuro YANAGIDA, Kenichiro WATANABE, Yuichi ATA, Motohiro SUGIHARA, Masato YUKUTAKE, Kouichi AWAYA, Yoshihisa IHARA, Yoshihiro SAWAE, Nobuyuki SHIMONO, Yukio KUMAGAI, Takahito HIROSE, Kei SATO, Kohtaro OHIZUMI, Youichiro ICHIKAWA, Masako TANAKA, Yoshiyuki MITSUTAKE, Kazuma FUJINO, Mikio KUBUSHIRO, Toshihiro HIGASHI, Kohei HARA, Shigeru KOHNO, Hironobu KOGA, Mitsuo KAKU, Keizo MATSUMOTO, Kazunori OHISHI, Kiyoshi SHIMA, Shinobu TAKENAKA, Masaru NASU, Yoichiro GOTO, Tohru YAMAZAKI, Hiroyuki NAGAI, Takayoshi TASHIRO, Hiroshi NAGAOKA, Kaoru NAKAMA, Nobuya OGAWA, and Nobuchika KUSANO

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, medicine.drug_class, Cefepime, Antibiotics, Ceftazidime, Microbial Sensitivity Tests, Internal medicine, Potency, Medicine, Humans, Aged, business.industry, Incidence (epidemiology), Bacterial pneumonia, General Medicine, Bacterial Infections, Pneumonia, Middle Aged, medicine.disease, Cephalosporins, Female, business, Drip infusion, Abnormal laboratory findings, medicine.drug
Abstract

The efficacy, safety and usefulness of cefepime (CFPM), a new cephem antibiotic, in bacterial pneumonia, were evaluated in a comparative study against ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0 g (nominal potency) twice daily for 14 days, and the following results were obtained. 1. A total of 183 cases were enrolled in this study. Efficacy rates ("good" or better responses) as evaluated by the subcommittee were 90.3% (65/72) in the CFPM group and 94.0% (63/67) in the CAZ group, with no significant difference between the 2 groups. 2. Efficacy rates ("good" or better responses), as evaluated by attending physicians, (in the same bacterial pneumonia cases which were subjected to evaluation by the subcommittee) were 87.5% (63/72) in the CFPM group and 89.6% (60/67) in the CAZ group, with no significant difference between the 2 groups. 3. Bacteriologically, eradication rates were 96.9% (31/32) in the CFPM group and 96.7% (29/30) in the CAZ group with no significant difference between the 2 groups. 4. The incidence of side effects was 5.9% (5/85) in the CFPM group and 4.8% (4/84) in the CAZ group, with no significant difference between the 2 groups. No significant difference was also found between the 2 groups in the incidence of abnormal laboratory findings; 28.4% (23/81) of the case in the CFPM group and 34.1% (28/82) in the CAZ group. 5. As for overall usefulness of the drug in bacterial pneumonia cases, utility rates ("useful" or better evaluations) as evaluated by the subcommittee were 88.9% (64/72) in the CFPM group and 92.5% (62/67) in the CAZ group. The rates as evaluated by investigators (in cases judged as evaluable by the subcommittee) were 87.5% (63/72) and 85.1% (57/67), respectively. There were no significant differences between the 2 groups. These results indicated that CFPM is very useful for the treatment of bacterial pneumonia.

Published
1992

21. [A comparative study of cefepime for chronic respiratory tract infections]

Author

Atsushi SAITO, Yoshiteru SHIGENO, Yuei IRABU, Hiroshi FUKUHARA, Hajime OHSHIRO, Takahiko MIYAKUNI, Jun INATOME, Soukichi ONODERA, Hitoshi NAKANO, Tetsuo SHIMIZU, Nobuhiro SASAKI, Toshiaki FUJIKANE, Yuka FUJITA, Takashi HIROSHIMA, Eiichi SAKAI, Akira SAITO, Yohmei HIRAGA, Mitsuhide OHMICHI, Tsukasa YOSHIDA, Hiromi KANAYAMA, Toshiharu ITO, Tamotsu TAKISHIMA, Yasuo TANNO, Ruriko SATO, Makoto TAKAHASHI, Masaharu SUGIYAMA, Masakichi MOTOMIYA, Akira WATANABE, Yoshihiro HONDA, Yutaka TOKUE, Kazunao NIIZUMA, Shigeo TAKIZAWA, Masataka KATSU, Katsutaka TORIKAI, Susumu SUETSUGU, Shunji YOSHIDA, Kaoru SHIMADA, Yasuyuki SANO, Yasuo ARAI, Takeru KOSHINO, Tetsuhei OGAWA, Yoshio KOBAYASHI, Hiroyuki KOBAYASHI, Takao OKUBO, Hirotada IKEDA, Shigeki ODAGIRI, Masanori MATSUMURA, Yasuhiko ASHIKARI, Yasutsugu AMANO, Akira SHOJI, Takashi SAKUMA, Nobuki AOKI, Kenzo TAKAGI, Kenichi YAMAKI, Kiyoshi SUZUKI, Yasunobu NODA, Hideo GONDA, Toshihiko TAKEUCHI, Johichi KATO, Fumiyuki KUZE, Takako MURAYAMA, Nobuaki IKEDA, Koichi NAKATANI, Kenji BANDO, Souichiro IKEDA, Tadaaki KURODA, Nobuhiro NARITA, Masayoshi SAWAKI, Keiichi MIKASA, Fumio MIKI, Rinzo SOEJIMA, Yoshihito NIKI, Jiro HINO, Masaru SUMI, Toshiharu MATSUSHIMA, Masayoshi KAWANISHI, Makoto KIMURA, Shunkichi HIRAKI, Yohichi WATANABE, Masashi ARAKI, Michiro YAMAKIDO, Kenji HASEGAWA, Takashi TSUYA, Kenichiro SADAMOTO, Masao KUWABARA, Masanobu OKADA, Kenichi ARITA, Masao DOI, Kazuhiro DAIDO, Jitsuro YANAGIDA, Kenichiro WATANABE, Yuichi ATA, Motohiro SUGIHARA, Masato YUKUTAKE, Kouichi AWAYA, Yoshihisa IHARA, Minoru YOSHIDA, Kentaro WATANABE, Takahito HIROSE, Kei SATO, Kohtaro OHIZUMI, Youichiro ICHIKAWA, Masako TANAKA, Kazuma FUJINO, Yoshiyuki MITSUTAKE, Mikio KUBUSHIRO, Toshihiro HIGASHI, Susumu HARADA, Yasuko HARADA, Kohei HARA, Shigeru KOHNO, Hironobu KOGA, Mitsuo KAKU, Keizo MATSUMOTO, Kazunori OHISHI, Hiroshi TANAKA, Kiyoshi SHIMA, Shinobu TAKENAKA, Masaru NASU, Yoichiro GOTO, Tohru YAMAZAKI, Hiroyuki NAGAI, Takayoshi TASHIRO, Nobuya OGAWA, and Nobuchika KUSANO

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, medicine.drug_class, Cefepime, Cephalosporin, Antibiotics, Ceftazidime, Microbial Sensitivity Tests, Internal medicine, medicine, Potency, Humans, Respiratory Tract Infections, Aged, Respiratory tract infections, Bacteria, business.industry, Incidence (epidemiology), Significant difference, General Medicine, Middle Aged, Cephalosporins, Chronic Disease, Female, business, medicine.drug
Abstract

The clinical efficacy, safety and usefulness of Cefepime (CFPM), a new cephem antibiotics, in chronic respiratory infections were evaluated in a comparative study against Ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0 g (nominal potency), twice daily for 14 days, and the following results were obtained: 1. A total of 170 cases were enrolled in this study. Efficacy rates ("good" or better responses) as evaluated by the subcommittee were 86.2% (56/65) in the CFPM group and 84.5% (60/71) in the CAZ group, with no significant difference between the two groups. 2. Efficacy rates ("good" or better responses) as evaluated by attending physicians were 83.3% (55/66) in the CFPM group and 84.5% (60/71) in the CAZ group with no significant difference between the two groups. 3. Bacteriologically, eradication rates were 83.3% (40/48) in the CFPM group and 88.2% (45/51) in the CAZ group, with no significant difference between the two groups. 4. Side effects occurred in none of the patients in the CAZ group and in 4 of the 66 patients in the CFPM group. There was a significant difference between the two groups (Fisher's test p = 0.0489). The incidence of abnormal laboratory findings were 17.6% (12/68) in the CFPM group and 21.1% (16/76) in the CAZ group. There was no significant difference between the two groups. 5. The utility rates evaluated by the subcommittee were 81.8% (54/66) in the CFPM group and 84.5% (60/71) in the CAZ group with no significant difference between the two groups. Only in the incidence of side effects, there was a significant difference between the two groups (Fisher's test p = 0.0489), but there was no significant difference in other items of efficacy, safety and usefulness between the two groups. These results indicate that CFPM is useful for the treatment of chronic respiratory tract infections.

Published
1992

22. Acute exposure to cigarette smoke induces airway hyperresponsiveness without airway inflammation in guinea pigs. Dose-response characteristics

Author

Masanori Nishikawa, Takao Okubo, Hirotada Ikeda, Tsutomu Fukuda, and Shunsuke Suzuki

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Neutrophils, Guinea Pigs, Vascular permeability, Bronchi, Guinea pig, Capillary Permeability, chemistry.chemical_compound, Leukocyte Count, Internal medicine, Smoke, Tobacco, medicine, Animals, Specific Airway Resistance, Evans Blue, Dose-Response Relationship, Drug, business.industry, Airway Resistance, respiratory system, Extravasation, respiratory tract diseases, Trachea, Dose–response relationship, Plants, Toxic, medicine.anatomical_structure, Endocrinology, chemistry, Anesthesia, Methacholine, Female, business, medicine.drug, Respiratory tract, Extravasation of Diagnostic and Therapeutic Materials
Abstract

We examined whether acute exposure to a low dose of cigarette smoke causes an increase in airway responsiveness in guinea pigs and whether the changes in airway responsiveness are accompanied by increased vascular permeability or neutrophil influx in the trachea. Animals were divided into four groups: groups exposed to 5, 10, or 20 puffs of cigarette smoke and a control group. Airway responsiveness was assessed by measuring specific airway resistance (SRaw) as a function of increasing concentration of inhaled methacholine (Mch) aerosol immediately, 5 h, and 24 h after exposure. In parallel studies, tracheal vascular permeability was quantified by measuring the tracheal extravasation of intravenously administered Evans blue dye, and neutrophil influx into the tracheal mucosa was quantified by counting cells within whole mounts of tracheas that were stained with Giemsa. Exposure to 5 puffs of cigarette smoke caused no changes in airway responsiveness. Exposure to 10 puffs induced airway hyperresponsiveness only immediately after exposure. Exposure to 20 puffs induced airway hyperresponsiveness not only immediately but also 5 h after exposure. There was a significant correlation between the dose (puffs) of cigarette smoke and increase in airway responsiveness immediately after exposure (r = 0.77; p less than 0.001). The tracheal extravasation of intravenously administered Evans blue dye and the number of neutrophils in the tracheal mucosa did not differ significantly from the corresponding control values at any time or in any exposed group. Furthermore, none of these changes was observed in the airways distal to the trachea of any animal immediately after exposure to 20 puffs of cigarette smoke.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1990

23. Effects of ozone exposure on experimental asthma in guinea pigs sensitized with ovalbumin through the airway

Author

Masanori Nishikawa, Takao Okubo, Hirotada Ikeda, Midori Sumitomo, Shunsuke Suzuki, Tsutomu Fukuda, and Tamotsu Kaneko

Subjects
Allergy, Ovalbumin, Immunology, Provocation test, Guinea Pigs, Guinea pig, Allergic sensitization, Ozone, medicine, Immunology and Allergy, Animals, Anaphylaxis, Sensitization, biology, business.industry, Immunization, Passive, General Medicine, medicine.disease, Asthma, medicine.anatomical_structure, Immunoglobulin G, biology.protein, Female, Airway, business, Respiratory tract
Abstract

As ozone (O3) is known to cause airway inflammation and hyperresponsiveness, we examined the effects of 03 exposure (1, 3, or 5 ppm, 2 h) on sensitization and provocation in guinea pigs sensitized with ovalbumin (OA) through the airway. In groups exposed to O3 before sensitization, 5 ppm increased the production of IgG1 antibodies and decreased the OA sensitization threshold from 0.01 to 0.002%. In those exposed before provocation, 1, 3, or 5 ppm of O3 decreased the OA provocation threshold from 0.5 to 0.02%, and this enhancement appeared to depend on airway hyperresponsiveness. We conclude that O3 exposure may play an important role in causing asthmatic attacks rather than enhancing allergic sensitization.

Published
1990

24. A Comparative Study Between Cefminox (MT-141) and Cefotaxime in Respiratory Tract Infections

Author

Fumio MIKI, Eiji INOUE, Masakazu TERAGAKI, Kaname AKIOKA, Minoru YOSHIYAMA, Toru HIRAGA, Tetsuto MURATA, Akira SAITO, Akira UJIIE, Morikuni ABE, Yoshinobu TAKASHIRO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Fumio NAGAHAMA, Takehito NAKABAYASHI, Tetsuji KOROKU, Yomei HIRAGA, Katsuo SUZUKI, Hiroshi KON, Yasumasa YOKOTA, Ryoji OHASHI, Jutaro SHIMOMURA, Yoichi GOCHO, Hisashi NISHIHARA, Kazuo TAKEBE, Mitsuo MASUDA, Seiichi MURAKAMI, Yoshihiro KUMASAKA, Mitsuo NAKAMURA, Tatsuro IRIE, Masashi YONEDA, Tamotsu TAKISHIMA, Yasuo TANNO, Kiyoshi KONNO, Kotaru OIZUMI, Seiichi AONUMA, Izumi HAYASHI, Tatsuya ABE, Masataka KATSU, Hisashi TAKIZUKA, Reiko SAITO, Keimei MASHIMO, Tetsuro UKAI, Hiroichi TANIMOTO, Ryuoh NAKATANI, Kunihiko YOSHIMURA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Koichiro NAKATA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Hideo IKEMOTO, Kazuyoshi WATANABE, Atsushi SAITO, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Hiroyuki KOBAYASHI, Kota KONO, Kenji TAKAMURA, Hiroshi OSHITANI, Kokichi FUKUSHIMA, Akira ITO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Keinosuke NOSE, Kazufuto FUKAYA, Tadashi TAKIGAMI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Hajimu TAKEDA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Kaoru OYAMA, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Katsutaka TORIKAI, Mutsumi ASHIHARA, Tatsuo SUGIHARA, Nobuo MAEKAWA, Michiyasu NAKANISHI, Tsuneo MATSUBARA, Nobuaki IKEDA, Ataka SHIBATA, Kenji TAKAMATSU, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Rinzo SOEJIMA, Yoshito NIKI, Chikara NAKAHAMA, Michifumi ADACHI, Osamu KURIMURA, Koji NOMA, Eiro TSUBURA, Masakazu TAMURA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Kenichi MATSUBA, Takahiro NAWATA, Masaro KAJI, Yoichiro ICHIKAWA, Nisaburo TANAKA, Toshiharu HAYASHI, Yoshiyuki MITSUTAKE, Kazuma FUJINO, Kohei HARA, Atushi SAITO, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Isao NAKAMURA, Munetaka KOMORI, Ken SHINZATO, Hirofumi OGATA, Naomi ITO, Keizo MATSUMOTO, Tsuyoshi NAGATAKE, Naoto RIKITOMI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Takashi ITOGA, Masaru NASU, Yoichiro GOTO, Jun GOTO, and Takayoshi TASHIRO

Subjects
Clinical Trials as Topic, medicine.medical_specialty, Cefotaxime, Respiratory tract infections, Cefminox, business.industry, Lung abscess, Pneumonia, General Medicine, medicine.disease, Gastroenterology, Chronic disease, Internal medicine, Chronic Disease, medicine, Humans, Cephamycins, Lung Abscess, business, Respiratory Tract Infections, medicine.drug
Published
1985
Full Text
View/download PDF

25. Comparative Study of the Effectiveness of Lenampicillin and Bacampicillin on Bacterial Pneumonia by Double Blind Method

Author

Fumio MIKI, Yosiyasu IKUNO, Eiji INOUE, Minoru YOSIYAMA, Tetsuto MURATA, Shin-ichi TANIZAWA, Kazuo SAKAMOTO, Hirozumi SAKAI, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Osamu YAJIMA, Akira UJIIE, Kazuo TAKEBE, Mitsuo MASUDA, Seiichi MURAKAMI, Takeshi OSONOI, Toshikazu MAEDA, Kazuo SASAKI, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Kosaku NAGAI, Tsukasa YOSHIDA, Syuji CHIBA, Kazuo SATO, Teruo HASUIKE, Shigeru TAMAKI, Izumi HAYASHI, Tadashi MIYAHARA, Atsushi SAITO, Hideo IKEMOTO, Kazuyoshi WATANABE, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Masataka KATSU, Hiroharu OGIHARA, Fuyuhiko HIGASHI, Toshio SEKIMOTO, Takeshi KAWAI, Akio ONAKA, Atsushi AJISAWA, Tetsuji KATAYAMA, Hayato MIYAJI, Yumiko MURAYAMA, Keimei MASHIMO, Chizuru ITO, Hiroichi TANIMOTO, Kunihiko YOSHIMURA, Naohiko CHONABAYASI, Tatsuo NAKATANI, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Ippei FUJIMORI, Yoshio KOBAYASHI, Yasushi NAKAMURA, Takao OKUBO, Akira ITO, Fumio MATSUMOTO, Kazufuto FUKAYA, Shigeki ODAGIRI, Hirotada IKEDA, Keinosuke NOSE, Kou MUROHASHI, Shin-ichiro WATANABE, Hajimu TAKEDA, Koichi WADA, Tomoko KABASAWA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Nobuki AOKI, Kaoru OYAMA, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Ikuji USAMI, Hirohiko NAGASAKA, Yasuo YAMADA, Tsuyoshi ITO, Naohiko TERAO, Hideaki KUROKI, Toshiyuki YAMAMOTO, Nobuo MAEKAWA, Michiyasu NAKANISHI, Hideki NISHIYAMA, Takayoshi YAMAMOTO, Yasutaku SHIBATA, Hiroyuki TSUJINO, Riichiro MIKAMI, Masayoshi SAWAKI, Yuruko OKAMOTO, Yube IIDA, Keigo MAEHARA, Hiroshi OKUBO, Yoshihiro UEDA, Kenji TAKAMATSU, Rinzo SOEJIMA, Yoshihito NIKI, Yukio NISHIMOTO, Akimitsu KAMITSUNA, Shigekiyo NAKANISHI, Michio YAMAKIDO, Kenji HASEGAWA, Kazumasa NOUMI, Osamu KURIMURA, Tadashi MASUDA, Eiro TSUBURA, Masakazu TAMURA, Tadashi NAKAYAMA, Etsuo SENOO, Kenji TANI, Yuji HIGUCHI, Toshihiko KAMEI, Yoshiro SAWAE, Kaoru OKADA, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Kazuhiro OKUNO, Rokushi OKA, Keizo MATSUMOTO, Tsuyoshi MAGATAKE, Naoto RIKITOMI, Masato HAYASHI, Ken-ichi HOSOYA, Kiyoshi ZAYASU, Yoshiro ARAKI, Masayuki ANDO, Mineharu SUGIMOTO, Hiroaki NAOE, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, Kiyoshi SHIMA, Sadanobu HIGUCHI, Takashi ITOGA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Kazumine KOBARI, and Masao NAKATOMI

Subjects
Adult, Male, Clinical Trials as Topic, medicine.medical_specialty, Adolescent, business.industry, Pneumonia, General Medicine, Middle Aged, medicine.disease, Gastroenterology, Double-Blind Method, Bacampicillin, Internal medicine, Humans, Medicine, Ampicillin, Female, business, Lenampicillin, Aged, medicine.drug
Published
1985
Full Text
View/download PDF

26. Comparative Study of the Effectiveness of Enoxacin and Amoxicillin on Bacterial Pneumonia by Double Blind Method

Author

Fumio MIKI, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Kazuo TAKEBE, Tamotsu TAKASHIMA, Shiroh IDA, Kiyoshi KONNO, Kotaro OIZUMI, Masako SASAKI, Akira WATANABE, Kikuo ONUMA, Seiichi AONUMA, Masataka KATSU, Yumiko MURAYAMA, Teruo AOYAGI, Mantaro HANYA, Hoichi NAGATOMI, Tadashi MIYAHARA, Kohya SHIBA, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Shin KAWAI, Kaoru SHIMADA, Takashi INAMATSU, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Junzabro KABE, Hiroyoshi ISHIBASHI, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Yoshitaka NAKAMORI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Koichiro NAKATA, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Kazufuto FUKAYA, Fumio MATSUMOTO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Hazimu TAKEDA, Osamu SEKINE, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OYAMA, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Toshiyuki YAMAMOTO, Nobuo MAEKAWA, Michiyasu NAKANISHI, Makoto MUTO, Takako MURAYAMA, Yasutaku SHIBATA, Riichiro MIKAMI, Masayoshi SAWAKI, Mikikazu KUNIMATSU, Kaoru HAMADA, Masashi FUJIMURA, Sumito CHOU, Yuruko OKAMOTO, Keigo MAEHARA, Yoshiro UEDA, Hiroshi OKUBO, Kenji TAKAMATSU, Rinzo SOEJIMA, Yoshihito NIKI, Tadakazu AISAKA, Eiro TUBURA, Masakazu TAMURA, Hidetoshi OGUCHI, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Kohei HARA, Atsushi SAITO, Kinichi IZUMIKAWA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Koichi WATANABE, Munetaka KOMORI, Kyoko YAMASHITA, Yukishige MIYAZAKI, Toshiyuki OE, Rokushi OKA, Kazuhiro OKUNO, Masao SAI, Yasuko UEDA, Keizo MATSUMOTO, Hiroshi SUZUKI, Harumi SHISHIDO, Kenji TSUCHIHASHI, Naoto RIKITOMI, Yoshiro ARAKI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Kiyoshi SHIMA, Sadanobu HIGUCHI, Shinobu TAKENAKA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Takashi ITOGA, Yuei IRABU, Yutoku KINJO, Masao NAKATOMI, Kazumine KOBARI, and Izumi HAYASHI

Subjects
Adult, Enoxacin, Male, medicine.medical_specialty, Gastroenterology, Double blind, Double-Blind Method, Internal medicine, Humans, Medicine, Naphthyridines, Aged, Clinical Trials as Topic, Bacteria, business.industry, Bacterial pneumonia, Amoxicillin, Bacterial Infections, Pneumonia, General Medicine, Middle Aged, medicine.disease, Anti-Bacterial Agents, Female, business, medicine.drug
Published
1984
Full Text
View/download PDF

27. Comparison of DL-8280 and Amoxicillin in the Treatment of Respiratory Tract Infections

Author

Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kota KONO, Sokichi ONODERA, Nobuhiro SASAKI, Fumio NAGAHAMA, Yoshikazu KAWAKAMI, Yukihiko HONMA, Michiyuki MATSUZAKI, Kazunori TANIMURA, Mikio INOUE, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Kazuo TAKEBE, Tomio ONUMA, Toyokazu TAMURA, Shuichiro YOSHIDA, Shigeru OCHIAI, Katsutoshi KARIYA, Akiko YAMANAKA, Naoyoshi MASAKI, Katsuhiro OKAMOTO, Masao TAMURA, Takashi ITO, Yoshikatsu NEMOTO, Seiki SATOH, Shiroh IDA, Tamotsu TAKISHIMA, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Izumi HAYASHI, Tatsuya ABE, Teruo AOYAGI, Yuichi KOIZUMI, Masataka KATSU, Masanori ADACHI, Hajimu TAKEDA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Isao NITTA, Kyoko WATANABE, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Atsushi SAITO, Kohya SHIBA, Tadashi MIYAHARA, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Ko FUKUI, Keimei MASHIMO, Yoshiji YAMANE, Kazuaki HANAOKA, Hiroichi TANIMOTO, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Ryuo NAKATANI, Koichiro NAKATA, Hideo IKEMOTO, Kazuyoshi WATANABE, Kaoru SHIMADA, Kyoko URAYAMA, Takashi INAMATSU, Yuzo FUNATSU, Fuyuhiko HIGASHI, Takao TAKIZAWA, Jun TAMAOKI, Junzaburo KABE, Hiroyoshi ISHIBASHI, Masako KATO, Toshio ITO, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Kazufuto FUKAYA, Fumio MATSUMOTO, Kaoru OYAMA, Kuninori SUZUKI, Kaoru SHIMOKATA, Keisuke NISHIWAKI, Shuzo SAKAI, Masanori MORISE, Yasunobu TOTANI, Masahito KATO, Toshihiko TAKEUCHI, Hidekazu HANAKI, Saburo KITAURA, Toshiyuki YAMAMOTO, Katsutaka TORIKAI, Yoichi ABE, Nobuo MAEKAWA, Michiyasu NAKANISHI, Takekuni IWATA, Kazukiyo OIDA, Ryoichi AMITANI, Yoshiro MOCHIZUKI, Yoshio TAGUCHI, Nobuo INABA, Yoshiro ODA, Akira KAGIOKA, Hiroyuki TSUJINO, Hitoshi NAKAI, Kyosuke ISHIHARA, Hiroko SAKAMOTO, Yoko YAMAGATA, Fumio MIKI, Kenji TAKAMATSU, Yuruko OKAMOTO, Keigo MAEHARA, Muneto YOSHIOKA, Yube IIDA, Kohjiro YASUNAGA, Hiroshi OKUBO, Yoshihiro UEDA, Rinzo SOEJIMA, Yoshito NIKI, Chikara NAKAHAMA, Masatoshi WATANABE, Jiro HINO, Osamu KURIMURA, Yoshihiko ARATANI, Hideo SASAKI, Hirofumi FUKUHARA, Yukio NISHIMOTO, Michio YAMAKIDO, Keiko IWAMOTO, Naomi KODOMARI, Eiro TSUBURA, Masakazu TAMURA, Hidetoshi OHGUCHI, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Hitoshi NAGANO, Hideto TSURUTANI, Reiko KISHIKAWA, Takashi ITOGA, Masaru NASU, Jun GOTO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Koichi WATANABE, Masamoto NAKANO, Akira IKEBE, Makoto Ishizaki, Tsunetoshi KOTEDA, Keizo MATSUMOTO, Harumi SHISHIDO, Kunio KUDO, Hisao KIMURA, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, Haruhiko TOKUOMI, Kiyoshi SHIMA, Sadanobu HIGUCHI, Shinobu TAKENAKA, Kazumine KOBARI, Masao NAKATOMI, and Yuei IRABU

Subjects
Adult, Male, Ofloxacin, medicine.medical_specialty, Haemophilus Infections, Gastroenterology, Anti-Infective Agents, Double-Blind Method, Internal medicine, Oxazines, medicine, Humans, Pseudomonas Infections, Bronchitis, Respiratory Tract Infections, Aged, Clinical Trials as Topic, Respiratory tract infections, business.industry, Amoxicillin, Pneumonia, General Medicine, Middle Aged, Bronchiectasis, Female, business, medicine.drug
Published
1984
Full Text
View/download PDF

28. [Comparative study of TMS-19-Q and midecamycin for respiratory tract infection by double-blind method]

Author

Hiroyuki KOBAYASHI, Tomoko NIHEI, Hiroaki TAKEDA, Kohta KOHNO, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Kazuo TAKEBE, Shiro KOSAKA, Teruo NAKAMURA, Shuichiro YOSHIDA, Masao TAMURA, Takashi ITO, Taro CHIBA, Ryoji OGATA, Kazuo TANIFUJI, Kotaro ITAKURA, Kiyoshi KONNO, Kotaro OIZUMI, Kosaku NAGAI, Izumi HAYASHI, Tatsuya ABE, Masataka KATSU, Shinji OKUI, Masanori ADACHI, Atsushi SAITO, Kohya SHIBA, Tadashi MIYAHARA, Tetsuro UGAI, Yoshiji YAMANE, Keimei MASHIMO, Keiichi NAKAGAWA, Masaru KOYAMA, Ryuji AKIYOSHI, Ichiro MURATA, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Fumio MATSUMOTO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Kaoru OYAMA, Toshiyuki YAMAMOTO, Masahito KATO, Kunio NANJO, Motoko YAMAMOTO, Hidekazu HANAKI, Hirohiko NAGASAKA, Tsuyoshi ITO, Toshihiko TAKEUCHI, Masakazu KOHNO, Fumio MIKI, Kenji TAKAMATSU, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Yoshihito NIKI, Hiroshi KAWANE, Masayoshi KAWANISHI, Chikara NAKAHAMA, Masatoshi WATANABE, Jiro HINO, Michio YAMAKIDO, Yuzo ODA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Masakazu TAMURA, Toshihiro GOTO, Eiro TSUBURA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Kohei HARA, Kinichi IZUMIKAWA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Munetaka KOMORI, Naomi ITO, Masao SAI, Hiromaru IWASAKI, Koichi WATANABE, Akira IKEBE, Kozo YAMADA, Keizo MATSUMOTO, Yoshio UZUKA, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Shukuro ARAKI, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, Haruhiko TOKUOMI, Takashi ITOGA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Kazumine KOBARI, Yuei IRABU, Yutoku KINJO, Masao NAKATOMI, and Tsuneo TANAKA

Subjects
medicine.medical_specialty, Clinical Trials as Topic, business.industry, General Medicine, Bacterial Infections, Pneumonia, Gastroenterology, Leucomycins, Midecamycin, Double blind, medicine.anatomical_structure, Double-Blind Method, Internal medicine, Pneumonia, Mycoplasma, Medicine, Humans, Miocamycin, business, medicine.drug, Respiratory tract
Published
1985

29. Danazol (an antigonadotropin) in the treatment of catamenial pneumothorax

Author

Hiroshi Minaguchi, Akemi JVIatsuyama, Tsuguo Uemura, and Hirotada Ikeda

Subjects
Adult, medicine.medical_specialty, media_common.quotation_subject, Diaphragm, Endometriosis, Catamenial pneumothorax, Asymptomatic, Menstruation, Antigonadotropin, Pneumoperitoneum, Pregnadienes, medicine, Humans, Ovulation, media_common, Danazol, business.industry, Obstetrics and Gynecology, Pneumothorax, Thoracic Neoplasms, medicine.disease, Surgery, Anesthesia, Female, medicine.symptom, business, medicine.drug
Abstract

Two cases of catamenial pneumothorax treated with danazol, an isoxazole derivative of 17α-ethinyl testosterone, are reported. The first patient, a 44-year-old woman who had had 31 attacks of spontaneous pneumothorax at the onset of menstruation in the past 7 years, was given 400 mg danazol daily for 6 months. Episodes did not reoccur during the treatment or for 5 months after the treatment, though ovulation was observed in the first menstrual cycle after the treatment. The second patient was a 33-year-old woman who had had recurrent right-sided chest pains related to the onset of menses. The endometrial implants in the diaphragm were excised but a right pneumothorax recurred at the first menstrual period after operation. After 4 months of therapy with danazol she has been asymptomatic for 20 months. Danazol therapy seems to be more effective on this disease and to have less side effects than other ovulation inhibiting drugs.

Published
1985

30. The effects of freeze-substitution media on the ultrastructure of inclusion bodies in type II pneumocytes of mouse lung processed by the cryofixation method

Author

Misao Ichikawa, Hirotada Ikeda, and Atsushi Ichikawa

Subjects
Inclusion Bodies, Male, Pathology, medicine.medical_specialty, Mice, Inbred C3H, Type-II Pneumocytes, Cytological Techniques, Lamellar granule, Biology, Inclusion bodies, Cryofixation, Mice, Microscopy, Electron, Freeze substitution, Freezing, Biophysics, medicine, Ultrastructure, Animals, Female, Mouse Lung, Instrumentation, Lung
Published
1984

31. [A well-controlled comparative study on ceftriaxone with cefotaxime in respiratory tract infections]

Author

Hiroyuki KOBAYASHI, Kenji TAKAMURA, Hiroshi OSHITANI, Tomoko NIHEI, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Kiyofumi ISHIKAWA, Morikuni ABE, Yoshihiko KURODA, Hiroyuki KUMANO, Yoshio KURIHARA, Tuyoshi KIKUIRI, Shuzaburo FUKUYAMA, Fumio NAGAHAMA, Shinya YASUDA, Akira SUZUKI, Yomei HIRAGA, Mitsuharu OGI, Akihiko KUZE, Hiroshi KON, Katsuo SUZUKI, Rensuke KURODA, Jutaro SHIMOMURA, Kazuo TAKEBE, Seiichi MURAKAMI, Morio SAGARA, Masahiro TSUTSUI, Shunichi MAEDA, Seiichi OHHIRA, Mitsuo MASUDA, Yuzo MORI, Kazuo SASAKI, Mitsuo SUZUKI, Makoto NAKAZONO, Kiyohito TAKAHASHI, Hisashi NAKAHATA, Shirou KOSAKA, Masao TAMURA, Takashi ITO, Takehisa MURAKAMI, Kohtaro ITAKURA, Tamotsu TAKISHIMA, Shiroh IDA, Kiyoshi KONNO, Kikuo ONUMA, Kotaro OIZUMI, Masako SASAKI, Akira WATANABE, Seiichi AONUMA, Reiko SASAKI, Izumi HAYASHI, Masataka KATSU, Keimei MASHIMO, Yoshiji YAMANE, Sumio YAMAOKA, Atsushi SAITO, Jingoro SHIMADA, Koya SHIBA, Takehisa YAMAJI, Toshio HOJO, Masanobu KAJI, Tadashi MIYAHARA, Hideo IKEMOTO, Kazuyoshi WATANABE, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IJIMA, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroichi TANIMOTO, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Naohiko CHONABAYASHI, Yoshitaka NAKAMORI, Koichiro NAKATA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Ippei FUJIMORI, Yoshio KOBAYASHI, Akio ONAKA, Kazufuto FUKAYA, Shigeki ODAGIRI, Kouu MUROHASHI, Hirotada IKEDA, Kaneo SUZUKI, Tamotsu KANEKO, Toshihiko TAKEUCHI, Toshiyuki YAMAMOTO, Masahito KATO, Kouichi WADA, Masaaki ARAKAWA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OYAMA, Nobuo MAEKAWA, Michiyasu NAKANISHI, Yujiro SUZUKI, Keijyu LEE, Hiroshi OKUBO, Yoshihiro UEDA, Yuruko OKAMOTO, Keigo MAEHARA, Seibun YONEZU, Yube IIDA, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Minoru YOSHIYAMA, Tetsuto MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Rinzo SOEJIMA, Yoshito NIKI, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Eiro TSUBURA, Masakazu TAMURA, Masaru NAKAGAWA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Hitoshi NAGANO, Chiharu KUBO, Takashi ITOGA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Toshiyuki OYE, Hiromaru IWASAKI, Toshiaki HAYASHI, Keizo MATSUMOTO, Yukio NOGUCHI, and Mikio TAGUCHI

Subjects
Adult, Male, medicine.medical_specialty, Cefotaxime, Respiratory tract infections, business.industry, Ceftriaxone, General Medicine, Middle Aged, Internal medicine, Medicine, Drug Evaluation, Humans, Female, business, Respiratory Tract Infections, medicine.drug, Aged
Published
1986

32. [Comparative clinical study of ceftazidime and cefotiam for respiratory tract infections by a double-blind method]

Author

Kohei HARA, Atsushi SAITO, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Isao NAKAMURA, Toshiro ODA, Kazuhiro OKUNO, Hiromaru IWASAKI, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Shinya YASUDA, Takehito NAKABAYASHI, Tetsuji KOROKU, Takahisa SAITO, Hiromichi HORIKAWA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Mitsunari NAKAMURA, Mitsuo ASAKAWA, Akira SUZUKI, Yoshiro ISHII, Kazuo TAKEBE, Morio SAGARA, Shuichiro YOSHIDA, Toyokazu TAMURA, Hideya MURABAYASHI, Naoki TAMAZAWA, Tomio ONUMA, Osamu UEHARA, Gen ENOOKA, Katsuhiro OKAMOTO, Naoyoshi MASAKI, Shigetoshi YANAGIYA, Hiroshi TAKAHASHI, Mitsunobu HONMA, Tomohiro KANAZAWA, Keiji TAKAHASHI, Hideki SASAKI, Shoji YASUI, Shiro IDA, Kiyo NISHIOKA, Tamotsu TAKISHIMA, Seiichi AONUMA, Kikuo ONUMA, Akira WATANABE, Masako SASAKI, Kotaro OIZUMI, Kiyoshi KONNO, Izumi HAYASHI, Tatsuya ABE, Shigeru TAMAKI, Masataka KATSU, Shinji OKUI, Mieko KAWAI, Fuyuhiko HIGASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Keimei MASHIMO, Tetsuro UKAI, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroichi TANIMOTO, Tatsuo NAKATANI, Koichiro NAKATA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Yasushi UEDA, Jingoro SHIMADA, Kohya SHIBA, Takehisa YAMAJI, Hironobu IHARA, Tadashi MIYAHARA, Keiichi NAKAGAWA, Masaru KOYAMA, KOUJIN KIN, Fukuo IIJIMA, Ryuji AKIYOSHI, Hiroyuki KAWAHARA, Takashi YAMAMOTO, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kohta KOHNO, Seiji MITA, Yoshio KOBAYASHI, Ippei FUJIMORI, Akira ITO, Kunihiko SHINDO, Jun CHIBA, Shohei NAGAOKA, Kokichi FUKUSHIMA, Hideyuki HASEGAWA, Makio KURIHARA, Shigeki ODAGIRI, Hirotada IKEDA, Kohu MUROHASHI, Kaneo SUZUKI, Tamotsu KANEKO, Kazufuto FUKAYA, Fumio MATSUMOTO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Hajimu TAKEDA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Yasuko YUASA, Isao NITTA, Kyoko WATANABE, Kaoru OYAMA, Ryusaku SHIMIZU, Kuninori SUZUKI, Fumio MIKI, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Muneto YOSHIOKA, Kojiro YASUNAGA, Yoshihiro UEDA, Hiroshi OKUBO, Rinzo SOEJIMA, Yoshihito NIKI, Osamu KURIHARA, Hideo SASAKI, Masao MIKITANI, Yoshihiko ARATANI, Eiji KANETO, Eiro TSUBURA, Toshihiro GOTO, Masakazu TAMURA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Nobuyuki HIROSE, Nobuaki SHIGEMATSU, Hitoshi NAGANO, Hiromi KIHARA, Masaro KAJI, Yoichiro ICHIKAWA, Fumio TANAKA, Syunji HAYASHI, Yoshiyuki MITSUTAKE, Kazuma FUJINO, Keizo MATSUMOTO, Tomoyuki HARADA, Takeshi ISHIZAKI, Taketsune MATSUMOTO, Tsunetoshi KOTEDA, Shigeru KOHNO, Masaru NASU, Jun GOTO, Takashi ITOGA, Tsutomu YAMAZAKI, Kunio NOMURA, Shigetake MIYAZAKI, Junichi SUETSUNA, Kazumine KOBARI, Masao NAKATOMI, Yutoku KINJO, Yoshio AOKI, and Kenji MARUMO

Subjects
Adult, Male, medicine.medical_specialty, Clinical Trials as Topic, Respiratory tract infections, Cefotiam, business.industry, Ceftazidime, General Medicine, Cefotaxime, Middle Aged, Double blind, Clinical study, Double-Blind Method, medicine, Humans, Female, Intensive care medicine, business, Respiratory Tract Infections, medicine.drug, Aged
Published
1984

34. [Comparative clinical study of ofloxacin and cefaclor in bacterial bronchitis]

Author

Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Kazuo TAKEBE, Tomio ONUMA, Shuichiro YOSHIDA, Yoshihiro KUMAZAKA, Shigeru OCHIAI, Mitsuo NAKAMURA, Tatsuro IRIE, Masashi YONEDA, Katsuhiro OKAMOTO, Shuichi TAKAHASHI, Masao TAMURA, Takashi ITO, Izumi HAYASHI, Tatsuya ABE, Teruo AOYAGI, Yuichi KOIZUMI, Masataka KATSU, Masanori ADACHI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Isao NITTA, Kyoko WATANABE, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Takao TAKIZAWA, Jun TAMAOKI, Atsushi SAITO, Kohya SHIBA, Takehisa YAMAJI, Masanobu KAJI, Tadashi MIYAHARA, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Kazuaki HANAOKA, Yoshiji YAMANE, Keimei MASHIMO, Hiroichi TANIMOTO, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Ryuo NAKATANI, Koichiro NAKATA, Hideo IKEMOTO, Kazuyoshi WATANABE, Tsuneo HAMAMOTO, Yuzo FUNATSU, Fuyuhiko HIGASHI, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Masako KATO, Takeshi KAWAI, Takashi KAMO, Hiroshi UCHIDA, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kota KONO, Shohei WATANABE, Ruey-Mei CHEN, Noriko MURAKI, Keiichi NAGAO, Harushige KANNO, Hirotaka TAKIZAWA, Norio KIKUCHI, Takeshi MITSUI, Akira ITO, Kunihiko SHINDO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Kazufuto FUKAYA, Fumio MATSUMOTO, Kaoru OYAMA, Katsutaka TORIKAI, Shinichi INADA, Yoichi ABE, Kunihiro ISHITANI, Nobuo MAEKAWA, Michiyasu NAKANISHI, Takekuni IWATA, Kazukiyo OIDA, Yoshio TAGUCHI, Kohei AOKI, Fumio MIKI, Kenji TAKAMATSU, Rinzo SOEJIMA, Yoshito NIKI, Masayasu KAWANISHI, Masatoshi WATANABE, Jiro HINO, Osamu KURIMURA, Yoshihiko ARATANI, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Takashi ITOGA, Masaru NASU, Jun GOTO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Yoshiaki FUKUDA, Masamoto NAKANO, Akira IKEBE, Makoto ISHIZAKI, Tsunetoshi KOTEDA, Mikio OKA, Keizo MATSUMOTO, Harumi SHISHIDO, Kenji TSUCHIHASHI, Naoto RIKITOMI, Hisao KIMURA, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, and Haruhiko TOKUOMI

Subjects
Adult, Male, medicine.medical_specialty, Ofloxacin, Clinical study, Double blind study, Anti-Infective Agents, Double-Blind Method, Internal medicine, Oxazines, Medicine, Humans, Cefaclor, Bronchitis, Aged, Cephalexin, Clinical Trials as Topic, business.industry, General Medicine, Bacterial Infections, Middle Aged, medicine.disease, Clinical trial, Female, Bacterial bronchitis, business, medicine.drug
Published
1984

35. [Double-blind comparative study of roxithromycin (RU 28965) and midecamycin acetate (MOM) in the treatment of pneumonia]

Author

Rinzo SOEJIMA, Yoshihito NIKI, Jiro HINO, Toshio KISHIMOTO, Yoshihisa NAKAGAWA, Masaru SUMI, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Yomei HIRAGA, Susumu ITO, Masao TAMURA, Takashi ITO, Takashi TUSRUYA, Hitoshi KOBAYASHI, Hiroshi KURAMITSU, Kazutoshi GOMI, Tamotsu TAKISHIMA, Shiroh IDA, Isao OHNO, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Seiichi AONUMA, Yushi NAKAI, Kousaku NAGAI, Kazuo SATOH, Izumi HAYASHI, Osamu SEKINE, Nobuki AOKI, Masataka KATSU, Shinji OKUI, Hisashi TAKIZUKA, Koichiro ASANO, Rieko AMAGAI, Kaoru SHIMADA, Yasuyuki SANO, Yasuhumi MIYAMOTO, Tadashi MIYAHARA, Jingoro SHIMADA, Kohya SHIBA, Hideo IKEMOTO, Kazuyoshi WATANABE, Junzaburo KABE, Koichiro KUDOH, Hiroichi TANIMOTO, Koichiro NAKATA, Yoshitaka NAKAMORI, Tatsuo NAKATANI, Naohiko CHONABAYASHI, Kentaro WATANABE, Masaru KOYAMA, Tatsuo KATO, Toshiaki TOMI, Hiroyuki KOBAYASHI, Hiroaki TAKEDA, Masahide KAWAHIRA, Ippei FUJIMORI, Mitsuo OBANA, Takao OKUBO, Akira ITOH, Hirotada IKEDA, Fumio MATSUMOTO, Kaoru OYAMA, Toshihiko TAKEUCHI, Masahito KATO, Yoshihiro UEDA, Hiroshi OKUBO, Hidekazu HANAKI, Fumio MIKI, Keiji KOBAYASHI, Yoji SHIMIZU, Kenzo SHIOTA, Michio YAMAKIDO, Kenji HASEGAWA, Koichi AWAYA, Toyofumi MITSUYAMA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Yoshiro SAWAE, Koji TAKAGI, Osamu KOHASHI, Nobuaki SHIGEMATSU, Masayuki MIYAZAKI, Katsuro YAGAWA, Ken-ichi OGATA, Toshihiko KOGA, Masahide TAKII, Hidenobu SHIGEOKA, Yoshihiro KATOH, Masaru NASU, Hideaki SHIGENO, Jun GOTO, Takayoshi TASHIRO, Kohei HARA, Keizo YAMAGUCHI, Shigeru KOHNO, Toshiaki HAYASHI, Hiroshi TOMITA, Naoshi SUYAMA, Akira YASUOKA, Kazuo SASAYAMA, Kiyokazu KOMORI, Toshiyuki OHE, Kin-ichi IZUMIKAWA, Hideo MASUMOTO, Mitsuo KAKU, Keizo MATSUMOTO, Naoto RIKITOMI, Tsuyoshi NAGATAKE, Masakazu TAKASUGI, Harumi SISIDO, Kiyoshi SHIMA, Taeo TAKENAKA, Atsushi SAITO, Yoshiteru SHIGENO, Yuei IRABU, and Kazunori TAMAKI

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Gastroenterology, Leucomycins, Double blind, Double blind study, Double-Blind Method, Japan, Internal medicine, medicine, Humans, Multicenter Studies as Topic, In patient, Clinical efficacy, Aged, Aged, 80 and over, Clinical Trials as Topic, business.industry, Roxithromycin, Significant difference, General Medicine, Pneumonia, Middle Aged, medicine.disease, Midecamycin acetate, Female, business, medicine.drug
Abstract

The clinical efficacy and safety of Roxithromycin (RU) were compared with those of Midecamycin acetate (MOM) in patients with pneumonia in a double blind study. RU and MOM were administered orally for 14 days with daily doses of 300 mg (150 mg b.i.d.) and 600 mg (200 mg t.i.d.), respectively. The following results were obtained. 1. RU and MOM were administered to a total of 204 patients (RU: 101, MOM: 103). The clinical efficacy was judged in 150 patients (RU: 70, MOM: 80), with 54 of the patients excluded from the total by the committee. 2. The clinical efficacy rates were 81.4% for RU and 70.0% for MOM on the basis of the committee's judgement. There was no significant difference between the two groups. In the evaluation of the clinical efficacy by the doctors in charge, the efficacy rates were 81.4% for RU and 67.5% for MOM, which constitutes a significant difference between the two groups (p less than 0.05). 3. No significant difference was found between the two drugs in bacteriological efficacy. 4. No significant differences were observed in either the incidence of side effects between RU (4.3%) and MOM (4.0%) or in abnormal changes in the laboratory findings. 5. Regarding the clinical usefulness judged by the committee, RU showed a significantly higher rate than MOM (79.2% vs. 67.9%). There was no significant difference in the judgement by the doctors in charge. From the above results, it was concluded that a daily dosage of 300 mg of RU was equal in usefulness to 600 mg daily of MOM in the treatment of mild to moderate pneumonia.

Published
1989

36. [Comparative clinical study of enoxacin (AT-2266, ENX) and cefaclor (CCL) in chronic respiratory tract infections by a double-blind method]

Author

Kohei HARA, Atsushi SAITO, Kinichi IZUMIKAWA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Koichi WATANABE, Munetaka KOMORI, Kyoko YAMASHITA, Yukishige MIYAZAKI, Toshiyuki OE, Masao SAI, Yasuko UEDA, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Kazuo TAKEBE, Tamotsu TAKISHIMA, Shiroh IDA, Kiyoshi KONNO, Kotaro OIZUMI, Masako SASAKI, Akira WATANABE, Kikuo ONUMA, Seiichi AONUMA, Izumi HAYASHI, Tatsuya ABE, Masataka KATSU, Yumiko MURAYAMA, Teruo AOYAGI, Mantaro HANYA, Hoichi NAGATOMI, Tadashi MIYAHARA, Kohya SHIBA, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Shin KAWAI, Keimei MASHIMO, Yoshiji YAMANE, Koichi MATSUMOTO, Kaoru SHIMADA, Takashi INAMATSU, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Yoshitaka NAKAMORI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Koichiro NAKATA, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Kazufuto FUKAYA, Fumio MATSUMOTO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Hazimu TAKEDA, Osamu SEKINE, Nobuki AOKI, Fusanosuke YAMASAKU, Kaoru OYAMA, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Toshiyuki YAMAMOTO, Nobuo MAEKAWA, Michiyasu NAKANISHI, Yasutaku SHIBATA, Hideki NISHIYAMA, Riichiro MIKAMI, Masayoshi SAWAKI, Mikikazu KUNIMATSU, Kaoru HAMADA, Masashi FUJIMURA, Sumito CHOU, Fumio MIKI, Yuruko OKAMOTO, Hiroshi OKUBO, Keigo MAEHARA, Kenji TAKAMATSU, Rinzo SOEJIMA, Yoshihito NIKI, Tsutomu NAKAHAMA, Masatoshi WATANABE, Michio YAMAKIDO, Fumiaki TSUKIYAMA, Toshiya NOMURA, Tadakazu AISAKA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Eiro TUBURA, Masakazu TAMURA, Hidetoshi OGUCHI, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Keizo MATSUMOTO, Hiroshi SUZUKI, Harumi SHISHIDO, Kenji TSUCHIHASHI, Naoto RIKITOMI, Yoshiro ARAKI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Kiyoshi SHIMA, Sadanobu HIGUCHI, Shinobu TAKENAKA, Masaru NASU, Juyn GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Yuuei IRABU, Masao NAKATOMI, and Kazumine KOBARI

Subjects
Adult, Enoxacin, Male, medicine.medical_specialty, Gastroenterology, Double blind, Clinical study, Double-Blind Method, Internal medicine, Medicine, Humans, Cefaclor, Naphthyridines, Respiratory Tract Infections, Aged, Cephalexin, Clinical Trials as Topic, Respiratory tract infections, Bacteria, business.industry, General Medicine, Middle Aged, Anti-Bacterial Agents, Chronic disease, Chronic Disease, Female, business, medicine.drug
Published
1984

Catalog

Books, media, physical & digital resources
See catalog results