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5 results on '"Hiroshi Negoro"'

2. A case of allochronic liver double cancer resected as minimal liver cancer

Author

Iwao Yabuuchi, Yasuharu Nomura, Toshikazu Itoh, Hiroshi Negoro, Akira Nogami, Yasuo Matsuda, Seiichiro Tarui, and Yoshitaka Ebi

Subjects
Oncology, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, medicine, Double cancer, Liver cancer, medicine.disease, business, Gastroenterology
Abstract

症例は68歳, 男性. C型慢性肝炎で通院中, 1993年5月腹部USにて肝左葉外側域に径1.2cm大の腫瘤を指摘され6月1回目の入院となった. この腫瘤は血管造影では腫瘍濃染像を認めず, 造影エコーにてhypoechoic change with rim signの所見を呈した. 7月肝左葉切除術が施行され, 組織は未分化の胆管細胞癌であった. 術後経過良好であったが, 1995年6月再び腹部USにて肝右葉S7に径1.7cm大の腫瘤が認められ2回目の入院となった. この腫瘤も血管造影陰性であったが, 造影エコーではhyperechoic changeを示した. 10月肝部分切除術が施行され, 組織は高分化型肝細胞癌であった. 原発性肝癌の中で, 同一肝内に肝細胞癌と胆管細胞癌の両者が異所性に認められる重複癌は極めてまれである. 本症例は胆管細胞癌と肝細胞癌が異時性に細小肝癌として発見され切除された興味ある症例と考え報告した.

Published
1997
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3. A case of heptic ciliated cyst

Author

Kiyoshi Kawano, Akira Nogami, Hiroshi Negoro, Yasuo Matsuda, Iwao Yabuuchi, Minoru Nishioka, and Yasuharu Nomura

Subjects
Hepatology, Cutaneous ciliated cyst, medicine, Anatomy, Biology, medicine.disease
Abstract

症例は44歳の男性.人間ドックの超音波検査で胆嚢部異常を指摘され当院受診.理学所見,肝機能検査,睡瘍マーカーなどは正常.超音波検査で肝床部に5×3cm大の嚢胞がみられ,内部に高エコーの腫瘍様病変を認めた.CT検査では不均一なlow densityを,ERCでは胆嚢頸部の圧排像を認め,血管撮影では異常を認めなかった.経皮的嚢胞穿刺で極めて粘稠な粘液を得,造影剤注入前後の超音波検査で腫瘍様病変の移動を確認し,同病変が粘液によるものと判定しえた.しかし造影所見で,卵円形の内腔に小陰影欠損を認め,小腫瘍の存在を否定しえず,拡大胆嚢切除術を施行した.嚢胞は単房性で腫瘤はなく,多列繊毛上皮と平滑筋層を有し,肝繊毛上皮嚢胞と診断した.本症は欧米では現在までに20例前後,本邦では最近10年間に5例しか報告されておらず,稀な疾患と考え報告した.

Published
1990
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4. Elevated serum lipoprotein (a) levels associated with ulcerative colitis in a young Japanese patient

Author

Seiichiro Tarui, Shigeharu Kawabata, Akira Nogami, Hiroshi Negoro, Ryoichi Arima, Masahiro Gomi, Shuichi Katagiri, and Iwao Yabuuchi

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Hyperlipoproteinemias, Rectum, Colonoscopy, Inflammatory bowel disease, Pathogenesis, Thromboembolism, Biopsy, Internal Medicine, medicine, Humans, Thrombus, medicine.diagnostic_test, biology, business.industry, General Medicine, Lipoprotein(a), medicine.disease, Ulcerative colitis, digestive system diseases, medicine.anatomical_structure, Phenotype, biology.protein, Colitis, Ulcerative, business
Abstract

Thromboembolism has been shown to play a role in the pathogenesis of inflammatory bowel disease (IBD). A possibility exists that lipoprotein (a) [Lp(a)], a newly-discovered prothrombotic factor, also participates in the development of at least some cases of IBD. Marked elevation of serum Lp(a) levels was observed in a young patient with ulcerative colitis. A biopsy specimen of the rectal mucosa showed findings compatible with ulcerative colitis, as well as small vessel thrombus occurring within the muscularis mucosa in the rectum. Serum Lp(a) levels were markedly elevated on admission (71 mg/dl), with a gradual decrease to 46 mg/dl on discharge. Moreover, serum Lp(a) levels decreased in parallel with clinical improvement. In the quiescent clinical stage, no small vessel thrombus was observed in the mucosa on follow-up colonoscopy. The association between IBD and hyper-Lp(a)-emia would be presumable but it has been, to our knowledge, previously unreported. The case reported here would be the first young patient, suggesting the presence of hyper-Lp(a)-emia and small vessel thrombus formation occurring in association with the development of ulcerative colitis.

Published
1997

5. Multi-epoch Modeling of TXS 0506+056 and Implications for Long-term High-energy Neutrino Emission.

Author

Maria Petropoulou, Kohta Murase, Marcos Santander, Sara Buson, Aaron Tohuvavohu, Taiki Kawamuro, Georgios Vasilopoulos, Hiroshi Negoro, Yoshihiro Ueda, Michael H. Siegel, Azadeh Keivani, Nobuyuki Kawai, Apostolos Mastichiadis, and Stavros Dimitrakoudis

Subjects
NEUTRINOS, SPECTRAL energy distribution, COMPTON scattering, ELECTRON density, ELECTRON scattering
Abstract

The IceCube report of a excess of 13 ± 5 neutrino events in the direction of the blazar TXS 0506+056 in 2014–2015 and the 2017 detection of a high-energy neutrino event, IceCube-170922A, during a gamma-ray flare from the same blazar, have revived the interest in scenarios for neutrino production in blazars. We perform comprehensive analyses on the long-term electromagnetic emission of TXS 0506+056 using optical, X-ray, and gamma-ray data from the All-Sky Automated Survey for Supernovae, the Neil Gehrels Swift Observatory, Monitor of All-sky X-ray Image, and the Fermi Large Area Telescope. We also perform numerical modeling of the spectral energy distributions (SEDs) in four epochs prior to 2017 with contemporaneous gamma-ray and lower-energy (optical and/or X-ray) data. We find that the multi-epoch SEDs are consistent with a hybrid leptonic scenario, where the gamma-rays are produced in the blazar zone via external inverse Compton scattering of accelerated electrons, and high-energy neutrinos are produced via the photomeson production process of co-accelerated protons. The multi-epoch SEDs can be satisfactorily explained with the same jet parameters and variable external photon density and electron luminosity. Using the maximal neutrino flux derived for each epoch, we put an upper limit of ∼0.4–2 on the muon neutrino number in 10 years of IceCube observations. Our results are consistent with the IceCube-170922A detection, which can be explained as an upper fluctuation from the average neutrino rate expected from the source, but in strong tension with the 2014–2015 neutrino flare. [ABSTRACT FROM AUTHOR]

Published
2020
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