1. Renal failure suppresses muscle irisin expression, and irisin blunts cortical bone loss in mice
- Author
-
Naoyuki Kawao, Miku Kawaguchi, Takashi Ohira, Hiroki Ehara, Yuya Mizukami, Yoshimasa Takafuji, and Hiroshi Kaji
- Subjects
Renal failure ,Irisin ,Osteopenia ,Muscle wasting ,Diseases of the musculoskeletal system ,RC925-935 ,Human anatomy ,QM1-695 - Abstract
Abstract Background Chronic renal failure induces bone mineral disorders and sarcopenia. Skeletal muscle affects other tissues, including bone, by releasing myokines. However, the effects of chronic renal failure on the interactions between muscle and bone remain unclear. Methods We investigated the effects of renal failure on bone, muscle, and myokines linking muscle to bone using a mouse 5/6 nephrectomy (Nx) model. Muscle mass and bone mineral density (BMD) were analysed by quantitative computed tomography 8 weeks after Nx. Results Nephrectomy significantly reduced muscle mass in the whole body (12.1% reduction, P
- Published
- 2022
- Full Text
- View/download PDF