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14 results on '"Hirose, Tatsuko"'

2. Retrospective details of false-positive and false-negative results in non-invasive prenatal testing for fetal trisomies 21, 18 and 13

Author

Suzumori, Nobuhiro, Sekizawa, Akihiko, Takeda, Eri, Samura, Osamu, Sasaki, Aiko, Akaishi, Rina, Wada, Seiji, Hamanoue, Haruka, Hirahara, Fumiki, Sawai, Hideaki, Nakamura, Hiroaki, Yamada, Takahiro, Miura, Kiyonori, Masuzaki, Hideaki, Nakayama, Setsuko, Kamei, Yoshimasa, Namba, Akira, Murotsuki, Jun, Yamaguchi, Masayuki, Tairaku, Shinya, Maeda, Kazuhisa, Kaji, Takashi, Okamoto, Yoko, Endo, Masayuki, Ogawa, Masaki, Kasai, Yasuyo, Ichizuka, Kiyotake, Yamada, Naoki, Ida, Akinori, Miharu, Norio, Kawaguchi, Satoshi, Hasuo, Yasuyuki, Okazaki, Tetsuya, Ichikawa, Mayuko, Izumi, Shunichiro, Kuno, Naohiko, Yotsumoto, Junko, Nishiyama, Miyuki, Shirato, Nahoko, Hirose, Tatsuko, and Sago, Haruhiko

Published
2021
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3. Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy

Author

Suzumori, Nobuhiro, Sekizawa, Akihiko, Ebara, Takeshi, Samura, Osamu, Sasaki, Aiko, Akaishi, Rina, Wada, Seiji, Hamanoue, Haruka, Hirahara, Fumiki, Izumi, Haruna, Sawai, Hideaki, Nakamura, Hiroaki, Yamada, Takahiro, Miura, Kiyonori, Masuzaki, Hideaki, Yamashita, Takahiro, Okai, Takashi, Kamei, Yoshimasa, Namba, Akira, Murotsuki, Jun, Tanemoto, Tomohiro, Fukushima, Akimune, Haino, Kazufumi, Tairaku, Shinya, Matsubara, Keiichi, Maeda, Kazutoshi, Kaji, Takashi, Ogawa, Masanobu, Osada, Hisao, Nishizawa, Haruki, Okamoto, Yoko, Kanagawa, Takeshi, Kakigano, Aiko, Kitagawa, Michihiro, Ogawa, Masaki, Izumi, Shunichiro, Katagiri, Yukiko, Takeshita, Naoki, Kasai, Yasuyo, Naruse, Katsuhiko, Neki, Reiko, Masuyama, Hisashi, Hyodo, Maki, Kawano, Yukie, Ohba, Takashi, Ichizuka, Kiyotake, Nagamatsu, Takeshi, Watanabe, Atsushi, Shirato, Nahoko, Yotsumoto, Junko, Nishiyama, Miyuki, Hirose, Tatsuko, and Sago, Haruhiko

Published
2018
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10. Evaluation of the clinical performance of noninvasive prenatal testing at a Japanese laboratory.

Author

Sasaki, Yuna, Yamada, Takahiro, Tanaka, Shiro, Sekizawa, Akihiko, Hirose, Tatsuko, Suzumori, Nobuhiro, Kaji, Takashi, Kawaguchi, Satoshi, Hasuo, Yasuyuki, Nishizawa, Haruki, Matsubara, Keiichi, Hamanoue, Haruka, Fukushima, Akimune, Endo, Masayuki, Yamaguchi, Masayuki, Kamei, Yoshimasa, Sawai, Hideaki, Miura, Kiyonori, Ogawa, Masaki, and Tairaku, Shinya

Subjects
DIAGNOSIS of Down syndrome, PATHOLOGICAL laboratories, PREDICTIVE tests, PRENATAL diagnosis, CONFIDENCE intervals, GENETIC testing, PREGNANT women, HIGH-risk pregnancy, GESTATIONAL age, CHROMOSOME abnormalities, MATERNAL age, DESCRIPTIVE statistics, TRISOMY 18 syndrome, GENETIC counseling
Abstract

Aim: We aimed to evaluate the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of noninvasive prenatal testing (NIPT) in high‐risk pregnant women. Methods: Pregnant women who underwent GeneTech NIPT, the most commonly used NIPT in Japan, between January 2015 and March 2019, at Japan NIPT Consortium medical sites were recruited for this study. The exclusion criteria were as follows: pregnant women with missing survey items, multiple pregnancy/vanishing twins, chromosomal abnormalities in the fetus other than the NIPT target disease, and nonreportable NIPT results. Sensitivity and specificity were calculated from the obtained data, and maternal age‐specific PPV and NPV were estimated. Results: Of the 45 504 cases, 44 263 cases fulfilling the study criteria were included. The mean maternal age and gestational weeks at the time of procedure were 38.5 years and 13.1 weeks, respectively. Sensitivities were 99.78% (95% confidence interval [95% CI]: 98.78–99.96), 99.12% (95% CI: 96.83–99.76), and 100% (95% CI: 88.30–100) for trisomies 21, 18, and 13, respectively. Specificities were more than 99.9% for trisomies 21, 18, and 13, respectively. Maternal age‐specific PPVs were more than 93%, 77%, and 43% at the age of 35 years for trisomies 21, 18, and 13, respectively. Conclusion: The GeneTech NIPT data showed high sensitivity and specificity in the detection of fetal trisomies 21, 18, and 13 in high‐risk pregnant women, and maternal age‐specific PPVs were obtained. These results could provide more accurate and improved information regarding NIPT for genetic counseling in Japan. [ABSTRACT FROM AUTHOR]

Published
2021
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11. Classification of factors involved in nonreportable results of noninvasive prenatal testing (NIPT) and prediction of success rate of second NIPT

Author

Suzumori, Nobuhiro, primary, Sekizawa, Akihiko, additional, Takeda, Eri, additional, Samura, Osamu, additional, Sasaki, Aiko, additional, Akaishi, Rina, additional, Wada, Seiji, additional, Hamanoue, Haruka, additional, Hirahara, Fumiki, additional, Kuriki, Hiroko, additional, Sawai, Hideaki, additional, Nakamura, Hiroaki, additional, Yamada, Takahiro, additional, Miura, Kiyonori, additional, Masuzaki, Hideaki, additional, Yamashita, Takahiro, additional, Kamei, Yoshimasa, additional, Namba, Akira, additional, Murotsuki, Jun, additional, Tanemoto, Tomohiro, additional, Fukushima, Akimune, additional, Haino, Kazufumi, additional, Tairaku, Shinya, additional, Matsubara, Keiichi, additional, Maeda, Kazutoshi, additional, Kaji, Takashi, additional, Ogawa, Masanobu, additional, Osada, Hisao, additional, Nishizawa, Haruki, additional, Okamoto, Yoko, additional, Kanagawa, Takeshi, additional, Kakigano, Aiko, additional, Endo, Masayuki, additional, Kitagawa, Michihiro, additional, Ogawa, Masaki, additional, Izumi, Shunichiro, additional, Katagiri, Yukiko, additional, Takeshita, Naoki, additional, Kasai, Yasuyo, additional, Naruse, Katsuhiko, additional, Neki, Reiko, additional, Masuyama, Hisashi, additional, Hyodo, Maki, additional, Kawano, Yukie, additional, Ohba, Takashi, additional, Ichizuka, Kiyotake, additional, Nagamatsu, Takeshi, additional, Watanabe, Atsushi, additional, Nishikawa, Naomi, additional, Hamajima, Naoki, additional, Shirato, Nahoko, additional, Yotsumoto, Junko, additional, Nishiyama, Miyuki, additional, Koide, Keiko, additional, Hirose, Tatsuko, additional, and Sago, Haruhiko, additional

Published
2019
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12. Postpartum questionnaire survey of women who tested negative in a non-invasive prenatal testing: examining negative emotions towards the test

Author

Hirose, Tatsuko, Shirato, Nahoko, Izumi, Mikiko, Miyagami, Keiko, and Sekizawa, Akihiko

Abstract

Non-invasive prenatal testing (NIPT) is used worldwide to screen for fetal aneuploidy. Although previous studies on the psychosocial aspects of NIPT have focused on satisfaction regarding the test, we surveyed women who experienced negative emotions after receiving NIPT. From January 2018 to March 2019, we surveyed pregnant women whose NIPT results were negative, one year after the test. Of the 526 respondents, 35 (6.7%) regretted receiving NIPT and blamed themselves for taking it. We assigned this 6.7% of respondents to the negative emotion group. Although, 76.5% of the participants in the negative emotion group reported they would like to take NIPT for their next pregnancy, it was significantly lower as compared to the control group (92%). Furthermore, 31.9% of respondents in the control group reported that they would recommend similar tests to their relatives and friends. Conversely, in the negative emotion group, this proportion was lower at 17.1%. This suggests that guilt over testing may be meaningful. Thus, this study showed that some NIPT examinees regretted taking the test and blamed themselves. Respondents reported experiencing stress, anxiety, and depression even before NIPT affirming that it is important to address pregnant women’s psychosocial status during pre-test genetic counseling.

Published
2021
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13. Current status of non‐invasive prenatal testing in Japan

Author

Samura, Osamu, primary, Sekizawa, Akihiko, additional, Suzumori, Nobuhiro, additional, Sasaki, Aiko, additional, Wada, Seiji, additional, Hamanoue, Haruka, additional, Hirahara, Fumiki, additional, Sawai, Hideaki, additional, Nakamura, Hiroaki, additional, Yamada, Takahiro, additional, Miura, Kiyonori, additional, Masuzaki, Hideaki, additional, Nakayama, Setsuko, additional, Okai, Takashi, additional, Kamei, Yoshimasa, additional, Namba, Akira, additional, Murotsuki, Jun, additional, Tanemoto, Tomohiro, additional, Fukushima, Akimune, additional, Haino, Kazufumi, additional, Tairaku, Shinya, additional, Matsubara, Keiichi, additional, Maeda, Kazuhisa, additional, Kaji, Takashi, additional, Ogawa, Masanobu, additional, Osada, Hisao, additional, Nishizawa, Haruki, additional, Okamoto, Yoko, additional, Kanagawa, Takeshi, additional, Kakigano, Aiko, additional, Kitagawa, Michihiro, additional, Ogawa, Masaki, additional, Izumi, Shunichiro, additional, Katagiri, Yukiko, additional, Takeshita, Naoki, additional, Kasai, Yasuyo, additional, Naruse, Katsuhiko, additional, Neki, Reiko, additional, Masuyama, Hisashi, additional, Hyodo, Maki, additional, Kawano, Yukie, additional, Ohba, Takashi, additional, Ichizuka, Kiyotake, additional, Kido, Yasuhiro, additional, Fukao, Toshiyuki, additional, Miharu, Norio, additional, Nagamatsu, Takeshi, additional, Watanabe, Atsushi, additional, Hamajima, Naoki, additional, Hirose, Masaya, additional, Sanui, Ayako, additional, Shirato, Nahoko, additional, Yotsumoto, Junko, additional, Nishiyama, Miyuki, additional, Hirose, Tatsuko, additional, and Sago, Haruhiko, additional

Published
2017
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14. Impact of the new government‐involved noninvasive prenatal testing certification system on the awareness of pregnant women about noninvasive prenatal testing in Japan.

Author

Shirato, Nahoko, Sekizawa, Akihiko, Miyagami, Keiko, Sakamoto, Miwa, Yamada, Takahiro, Hirose, Tatsuko, Ikebukuro, Shin, Nakamura, Takeshi, Mizutani, Akane, Ikemoto, Mai, Izum, Mikiko, Seino, Hitomi, Yamada, Shigehito, Suzumori, Nobuhiro, Yoshihashi, Hiroshi, Samura, Osamu, Sawai, Hideaki, Sago, Haruhiko, and Okuyama, Torayuki

Subjects
*PREGNANT women, *NURSES, *PRENATAL diagnosis, *GOVERNMENT regulation, *BLOOD sampling, *TEST systems
Abstract

Aim Methods Results Conclusions In Japan, noninvasive prenatal testing (NIPT) has been performed by facilities accredited by the Japanese Society of Obstetrics and Gynecology since 2013. However, since 2016, with the implementation of NIPT, which can only be performed by blood sampling, non‐obstetricians have been involved in prenatal testing. Therefore, in July 2022, a new government‐involved NIPT certification system based on Health Sciences Council guidelines was introduced to ensure access to prenatal testing information for pregnant women.This survey was conducted in February 2023 and was the first survey after the certification system implementation. We conducted a web‐based survey of 1227 pregnant women and nursing mothers who underwent NIPT after July 2022 to evaluate their experiences.Respondents were categorized by certification status as certified (C: 56%), non‐certified (non‐C: 23%), or uncertain (Q: 20%). The C group with a higher mean age at examination (35.0 ± 4.5 years) paid lower examination fees, received longer pre‐ and post‐examination explanations, and underwent more weekday examinations (80%) than the other groups. Most respondents, 67%, 48%, and 53% in the C, non‐C, and Q groups, respectively (p < 0.0001), stated that “NIPT needs to be regulated by the government or academic societies.” The non‐C group was more likely to say, “Insufficient post‐test explanations at the laboratory made me more anxious,” than the other groups when the testing results were non‐negative (p = 0.015).Despite government regulation, some pregnant women choose convenience over certified facilities, risking inadequate care. The government should ensure that NIPT is a safe option for all pregnant women. [ABSTRACT FROM AUTHOR]

Published
2024
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