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4. Neural responses to syllable-induced P1m and social impairment in children with autism spectrum disorder and typically developing Peers.

Author

Sano, Masuhiko, Hirosawa, Tetsu, Yoshimura, Yuko, Hasegawa, Chiaki, An, Kyung-Min, Tanaka, Sanae, Yaoi, Ken, Naitou, Nobushige, and Kikuchi, Mitsuru

Subjects
*CHILDREN with autism spectrum disorders, *MULTIPLE regression analysis
Abstract

In previous magnetoencephalography (MEG) studies, children with autism spectrum disorder (ASD) have been shown to respond differently to speech stimuli than typically developing (TD) children. Quantitative evaluation of this difference in responsiveness may support early diagnosis and intervention for ASD. The objective of this research is to investigate the relationship between syllable-induced P1m and social impairment in children with ASD and TD children. We analyzed 49 children with ASD aged 40–92 months and age-matched 26 TD children. We evaluated their social impairment by means of the Social Responsiveness Scale (SRS) and their intelligence ability using the Kaufman Assessment Battery for Children (K-ABC). Multiple regression analysis with SRS score as the dependent variable and syllable-induced P1m latency or intensity and intelligence ability as explanatory variables revealed that SRS score was associated with syllable-induced P1m latency in the left hemisphere only in the TD group and not in the ASD group. A second finding was that increased leftward-lateralization of intensity was correlated with higher SRS scores only in the ASD group. These results provide valuable insights but also highlight the intricate nature of neural mechanisms and their relationship with autistic traits. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Effect of transcranial direct current stimulation on the functionality of 40 Hz auditory steady state response brain network: graph theory approach

Author

Hirosawa, Tetsu, primary, Soma, Daiki, additional, Miyagishi, Yoshiaki, additional, Furutani, Naoki, additional, Yoshimura, Yuko, additional, Kameya, Masafumi, additional, Yamaguchi, Yohei, additional, Yaoi, Ken, additional, Sano, Masuhiko, additional, Kitamura, Koji, additional, Takahashi, Tetsuya, additional, and Kikuchi, Mitsuru, additional

Published
2023
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20. Atypical Resting State Functional Neural Network in Children With Autism Spectrum Disorder: Graph Theory Approach

Author

Soma, Daiki, primary, Hirosawa, Tetsu, additional, Hasegawa, Chiaki, additional, An, Kyung-min, additional, Kameya, Masafumi, additional, Hino, Shoryoku, additional, Yoshimura, Yuko, additional, Nobukawa, Sou, additional, Iwasaki, Sumie, additional, Tanaka, Sanae, additional, Yaoi, Ken, additional, Sano, Masuhiko, additional, Shiota, Yuka, additional, Naito, Nobushige, additional, and Kikuchi, Mitsuru, additional

Published
2021
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24. Effect of CNTNAP2 polymorphism on receptive language in children with autism spectrum disorder without language developmental delay.

Author

Shiota, Yuka, Hirosawa, Tetsu, Yoshimura, Yuko, Tanaka, Sanae, Hasegawa, Chiaki, Iwasaki, Sumie, Sano, Masuhiko, An, Kyung‐min, Yokoyama, Shigeru, and Kikuchi, Mitsuru

Abstract

Aim: The receptive language ability of individuals with autism spectrum disorder (ASD) seems to lag behind expressive language ability. Several autism‐related genes may influence this developmental delay. Polymorphism of one such gene, namely, the contactin‐associated protein‐like 2 gene (CNTNAP2), affects receptive language in individuals with language delay. However, the association between CNTNAP2 polymorphism and receptive language in individuals with no language delay remains unclear. Methods: We included 59 children with ASD and 57 children with typical development in this study and investigated this association using coarse‐grained exact matching. Results: We present the first evidence of an association between CNTNAP2 rs2710102 (A‐allele carrier) and reduced receptive language ability in children with ASD whose language development was not delayed. Similarly, among children with typical development, A‐allele carriers had lower receptive language ability, but the difference was non‐significant. Conclusions: It is possible that the effect of rs2710102 on receptive language ability is larger in the presence of autism‐related genes. Consequently, we speculate that the effect of rs2710102 on receptive language ability would be exerted in combination with other genes. These findings provide new insights into the genetic interactions between mutations associated with common language disorders and ASD and identify molecular mechanisms and risk alleles that contribute to receptive vocabulary. These findings also provide practical guidance in terms of providing candidate genetic markers that may provide opportunities for targeted early intervention to stratify risk and improve prognosis for poor receptive language development in children with ASD. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Epileptiform discharges relate to altered functional brain networks in autism spectrum disorders

Author

Hirosawa, Tetsu, primary, An, Kyung-min, additional, Soma, Daiki, additional, Shiota, Yuka, additional, Sano, Masuhiko, additional, Kameya, Masafumi, additional, Hino, Shoryoku, additional, Naito, Nobushige, additional, Tanaka, Sanae, additional, Yaoi, Ken, additional, Iwasaki, Sumie, additional, Yoshimura, Yuko, additional, and Kikuchi, Mitsuru, additional

Published
2021
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31. S14-3 Long-term effects of interictal epileptiform discharge on cognitive development and sociality in children with ASD

Author

Hirosawa, Tetsu, primary, Sowman, Paul F., additional, Fukai, Mina, additional, Kameya, Masafumi, additional, Soma, Daiki, additional, Hino, Shoryoku, additional, Kitamura, Tatsuru, additional, An, Kyung-Min, additional, Takahashi, Tetsuya, additional, Yoshimura, Yuko, additional, Miyagishi, Yoshiaki, additional, Hasegawa, Chiaki, additional, Saito, Daisuike, additional, Ikeda, Takashi, additional, and Kikuchi, Mitsuru, additional

Published
2020
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33. Different associations between intelligence and social cognition in children with and without autism spectrum disorders

Author

Hirosawa, Tetsu, primary, Kontani, Keiko, additional, Fukai, Mina, additional, Kameya, Masafumi, additional, Soma, Daiki, additional, Hino, Shoryoku, additional, Kitamura, Tatsuru, additional, Hasegawa, Chiaki, additional, An, Kyung-min, additional, Takahashi, Tetsuya, additional, Yoshimura, Yuko, additional, and Kikuchi, Mitsuru, additional

Published
2020
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34. Relationship between epileptiform discharges and social reciprocity or cognitive function in children with and without autism spectrum disorders: An MEG study

Author

Hirosawa, Tetsu, primary, Sowman, Paul F., additional, Fukai, Mina, additional, Kameya, Masafumi, additional, Soma, Daiki, additional, Hino, Shoryoku, additional, Kitamura, Tatsuru, additional, An, Kyung‐min, additional, Yoshimura, Yuko, additional, Hasegawa, Chiaki, additional, Saito, Daisuke, additional, Ikeda, Takashi, additional, and Kikuchi, Mitsuru, additional

Published
2020
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37. Association Between Magnetoencephalographic Interictal Epileptiform Discharge and Cognitive Function in Young Children With Typical Development and With Autism Spectrum Disorders

Author

Hirosawa, Tetsu, primary, Kikuchi, Mitsuru, additional, Fukai, Mina, additional, Hino, Shoryoku, additional, Kitamura, Tatsuru, additional, An, Kyung-Min, additional, Sowman, Paul, additional, Takahashi, Tetsuya, additional, Yoshimura, Yuko, additional, Miyagishi, Yoshiaki, additional, and Minabe, Yoshio, additional

Published
2018
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40. Oxytocin attenuates feelings of hostility depending on emotional context and individuals' characteristics

Author

Hirosawa, Tetsu, Kikuchi, Mitsuru, Higashida, Haruhiro, Okumura, Eiichi, Ueno, Sanae, Shitamichi, Kiyomi, Yoshimura, Yuko, Munesue, Toshio, Tsubokawa, Tsunehisa, Haruta, Yasuhiro, Nakatani, Hideo, Hashimoto, Takanori, Minabe, Yoshio, Hirosawa, Tetsu, Kikuchi, Mitsuru, Higashida, Haruhiro, Okumura, Eiichi, Ueno, Sanae, Shitamichi, Kiyomi, Yoshimura, Yuko, Munesue, Toshio, Tsubokawa, Tsunehisa, Haruta, Yasuhiro, Nakatani, Hideo, Hashimoto, Takanori, and Minabe, Yoshio

Abstract

In humans, oxytocin (OT) enhances prosocial behaviour. However, it is still unclear how the prosocial effects of OT are modulated by emotional features and/or individuals' characteristics. In a placebo-controlled design, we tested 20 healthy male volunteers to investigate these behavioural and neurophysiological modulations using magnetoencephalography. As an index of the individuals' characteristics, we used the empathy quotient (EQ), the autism spectrum quotient (AQ), and the systemising quotient (SQ). Only during the perception of another person's angry face was a higher SQ a significant predictor of OT-induced prosocial change, both in the behavioural and neurophysiological indicators. In addition, a lower EQ was only a significant predictor of OT-induced prosocial changes in the neurophysiological indicators during the perception of angry faces. Both on the behavioural and the neurophysiological level, the effects of OT were specific for anger and correlated with a higher SQ.

Published
2017

41. A custom magnetoencephalography device reveals brain connectivity and high reading/decoding ability in children with autism

Author

Kikuchi, Mitsuru, Yoshimura, Yuko, Shitamichi, Kiyomi, Ueno, Sanae, Hirosawa, Tetsu, Munesue, Toshio, Ono, Yasuki, Tsubokawa, Tsunehisa, Haruta, Yasuhiro, Oi, Manabu, Niida, Yo, Remijn, Gerard B., Takahashi, Tsutomu, Suzuki, Michio, Higashida, Haruhiro, Mianabe, Yoshio, Kikuchi, Mitsuru, Yoshimura, Yuko, Shitamichi, Kiyomi, Ueno, Sanae, Hirosawa, Tetsu, Munesue, Toshio, Ono, Yasuki, Tsubokawa, Tsunehisa, Haruta, Yasuhiro, Oi, Manabu, Niida, Yo, Remijn, Gerard B., Takahashi, Tsutomu, Suzuki, Michio, Higashida, Haruhiro, and Mianabe, Yoshio

Abstract

A subset of individuals with autism spectrum disorder (ASD) performs more proficiently on certain visual tasks than may be predicted by their general cognitive performances. However, in younger children with ASD (aged 5 to 7), preserved ability in these tasks and the neurophysiological correlates of their ability are not well documented. In the present study, we used a custom child-sized magnetoencephalography system and demonstrated that preserved ability in the visual reasoning task was associated with rightward lateralisation of the neurophysiological connectivity between the parietal and temporal regions in children with ASD. In addition, we demonstrated that higher reading/decoding ability was also associated with the same lateralisation in children with ASD. These neurophysiological correlates of visual tasks are considerably different from those that are observed in typically developing children. These findings indicate that children with ASD have inherently different neural pathways that contribute to their relatively preserved ability in visual tasks.

Published
2017

44. A pilot study of serotonergic modulation after long‐term administration of oxytocin in autism spectrum disorder

Author

Hirosawa, Tetsu, primary, Kikuchi, Mitsuru, additional, Ouchi, Yasuomi, additional, Takahashi, Tetsuya, additional, Yoshimura, Yuko, additional, Kosaka, Hirotaka, additional, Furutani, Naoki, additional, Hiraishi, Hirotoshi, additional, Fukai, Mina, additional, Yokokura, Masamichi, additional, Yoshikawa, Etsuji, additional, Bunai, Tomoyasu, additional, and Minabe, Yoshio, additional

Published
2017
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46. Atypical Bilateral Brain Synchronization in the Early Stage of Human Voice Auditory Processing in Young Children with Autism

Author

Kurita, Toshiharu, primary, Kikuchi, Mitsuru, additional, Yoshimura, Yuko, additional, Hiraishi, Hirotoshi, additional, Hasegawa, Chiaki, additional, Takahashi, Tetsuya, additional, Hirosawa, Tetsu, additional, Furutani, Naoki, additional, Higashida, Haruhiro, additional, Ikeda, Takashi, additional, Mutou, Kouhei, additional, Asada, Minoru, additional, and Minabe, Yoshio, additional

Published
2016
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47. Attentional Control and Interpretation of Facial Expression after Oxytocin Administration to Typically Developed Male Adults

Author

Hirosawa, Tetsu, primary, Kikuchi, Mitsuru, additional, Okumura, Eiichi, additional, Yoshimura, Yuko, additional, Hiraishi, Hirotoshi, additional, Munesue, Toshio, additional, Takesaki, Natsumi, additional, Furutani, Naoki, additional, Ono, Yasuki, additional, Higashida, Haruhiro, additional, and Minabe, Yoshio, additional

Published
2015
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48. Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder

Author

Kikuchi, Mitsuru, primary, Yoshimura, Yuko, additional, Shitamichi, Kiyomi, additional, Ueno, Sanae, additional, Hiraishi, Hirotoshi, additional, Munesue, Toshio, additional, Hirosawa, Tetsu, additional, Ono, Yasuki, additional, Tsubokawa, Tsunehisa, additional, Inoue, Yoshihiro, additional, Oi, Manabu, additional, Niida, Yo, additional, Remijn, Gerard B., additional, Takahashi, Tsutomu, additional, Suzuki, Michio, additional, Higashida, Haruhiro, additional, and Minabe, Yoshio, additional

Published
2013
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49. A custom magnetoencephalography device reveals brain connectivity and high reading/decoding ability in children with autism

Author

Kikuchi, Mitsuru, primary, Yoshimura, Yuko, additional, Shitamichi, Kiyomi, additional, Ueno, Sanae, additional, Hirosawa, Tetsu, additional, Munesue, Toshio, additional, Ono, Yasuki, additional, Tsubokawa, Tsunehisa, additional, Haruta, Yasuhiro, additional, Oi, Manabu, additional, Niida, Yo, additional, Remijn, Gerard B., additional, Takahashi, Tsutomu, additional, Suzuki, Michio, additional, Higashida, Haruhiro, additional, and Minabe, Yoshio, additional

Published
2013
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50. Altered brain connectivity in 3-to 7-year-old children with autism spectrum disorder

Author

Kikuchi, Mitsuru, primary, Shitamichi, Kiyomi, additional, Yoshimura, Yuko, additional, Ueno, Sanae, additional, Hiraishi, Hirotoshi, additional, Hirosawa, Tetsu, additional, Munesue, Toshio, additional, Nakatani, Hideo, additional, Tsubokawa, Tsunehisa, additional, Haruta, Yasuhiro, additional, Oi, Manabu, additional, Niida, Yo, additional, Remijn, Gerard B., additional, Takahashi, Tsutomu, additional, Suzuki, Michio, additional, Higashida, Haruhiro, additional, and Minabe, Yoshio, additional

Published
2013
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