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Yuriko Abe1), Mamoru Ayusawa1), Masataka Kato1), Hirofumi Watanabe1), Ami Cho1), Akiko Komori1), Hiromi Okuma1), Rie Ichikawa1), Hiroshi Kamiyama1), Naokata Sumitomo2), Sango Ito1), and Shori Takahashi1) 1) Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan 2) Department of Pediatric Cardiology, Saitama Medical University International Medical Center, Saitama, Japan

The large HDL subclass is considered to possess cardioprotective properties. The purpose of this study is to determine the relationship among abdominal adiposity, insulin resistance and HDL subclass profiles of Japanese schoolchildren.The study subjects included 164 children (79 boys and 85 girls). We obtained waist to height ratio (WHtR), lipid profile, and HOMA-IR. The HDL subclass profile was analyzed by HPLC.Children of either sex with abdominal obesity (WHtR≥0.5) had reduced concentrations of very large, large, and medium HDLC in conjunction with elevated triglyceride (TG) concentrations and HOMA-IR. WHtR was inversely related to the concentrations of very large (boys: r=-0.5306, p0.0001; girls: r=-0.3483, p=0.0011), large (r=-0.6168, p0.0001; r=-0.4387, p0.0001), and medium (r=-0.4170, p=0.0001; r=-0.4116, p0.0001) HDLC. The multiple regression analyses revealed that WHtR was an independent factor of the concentrations of very large, large, small, and very small HDLC in boys and the concentrations of large and medium HDLC in girls.In Japanese schoolchildren, abdominal obesity is associated with atherogenic HDL subclass profile. Abdominal obesity may be an important target for the prevention and management of HDL subclass alteration, even in children who do not suffer from insulin resistance or hypertriglyceridemia.

We present a case of a 9-month-old girl in whom malignant polymorphic ventricular tachycardia (VT) was successfully controlled by radiofrequency catheter ablation under guidance with a three-dimensional mapping system. The VTs originated from the left ventricular lateral wall, left ventricular anterior wall, and left ventricular apex. At least six types of VTs were documented during the electrophysiology study. All VTs were successfully controlled after two sessions of radiofrequency catheter ablation, and she was discharged from our hospital on propranolol, mexiletine, flecainide, and aprindine.

Background: Alterations in the very low-density lipoprotein (VLDL) subclass profile have been demonstrated in obese and insulin resistant adults; however, little information on VLDL subclasses is available in children. We determined the association between abdominal adiposity, insulin resistance, and triglyceride (TG) levels in each VLDL subclass in Japanese school children. Methods: One hundred sixty-four children (79 boys and 85 girls), 10.9 ± 1.6 years of age (mean ± SD), were recruited. We obtained the waist-to-height ratio (WHtR), lipid profile, and HOMA-R data from all children. The VLDL subclass profile was analyzed by HPLC. Results: Children of either gender with abdominal obesity (WHtR ≥ 0.5) had higher concentrations of large, medium, and small VLDL-TG in conjunction with the shift to larger size and elevated HOMA-R. The WHtR was positively related to concentrations of large (boys: r = 0.5800, p < 0.0001; girls: r = 0.3841, p = 0.0003) and medium (r = 0.5265, p < 0.0001; r = 0.3320, p = 0.0019) VLDL-TG. The small VLDL-TG concentration was positively correlated to the WHtR in boys (r = 0.4902, p < 0.0001), but not girls. In multiple regression analyses, the WHtR was an independent determinant of large, medium, and small VLDL-TG concentrations in boys, but not in girls, taking HOMA-R into account. Conclusions: Abdominal obesity was associated with the VLDL subclass profile in Japanese school children; however, the impact of abdominal adiposity on the VLDL subclass alteration demonstrated a gender difference.

The effects of short naps and exercise on the sleep quality and mental health of elderly people was investigated. 'Interventions' by short naps after lunch and exercise of moderate intensity in the evening were carried out for 4 weeks. After the 'intervention', awake time after sleep onset decreased significantly and sleep efficiency increased significantly, demonstrating that sleep quality had improved. Also, the frequency of nodding in the evening decreased significantly. These results demonstrate that proper awakening maintenance in the evening was effective in improving sleep quality. After the 'intervention', mental health and volition and physical health had also improved with improving sleep quality.