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661 results on '"Hirokawa N"'

1. The Transcriptional Landscape of the Mammalian Genome

Author

Carninci, P., Kasukawa, T., Katayama, S., Gough, J., Frith, M. C., Maeda, N., Oyama, R., Ravasi, T., Lenhard, B., Wells, C., Kodzius, R., Shimokawa, K., Bajic, V. B., Brenner, S. E., Batalov, S., Forrest, A. R. R., Zavolan, M., Davis, M. J., Wilming, L. G., Aidinis, V., Allen, J. E., Ambesi-Impiombato, A., Apweiler, R., Aturaliya, R. N., Bailey, T. L., Bansal, M., Baxter, L., Beisel, K. W., Bersano, T., Bono, H., Chalk, A. M., Chiu, K. P., Choudhary, V., Christoffels, A., Clutterbuck, D. R., Crowe, M. L., Dalla, E., Dalrymple, B. P., de Bono, B., Della Gatta, G., di Bernardo, D., Down, T., Engstrom, P., Fagiolini, M., Faulkner, G., Fletcher, C. F., Fukushima, T., Furuno, M., Futaki, S., Gariboldi, M., Georgii-Hemming, P., Gingeras, T. R., Gojobori, T., Green, R. E., Gustincich, S., Harbers, M., Hayashi, Y., Hensch, T. K., Hirokawa, N., Hill, D., Huminiecki, L., Iacono, M., Ikeo, K., Iwama, A., Ishikawa, T., Jakt, M., Kanapin, A., Katoh, M., Kawasawa, Y., Kelso, J., Kitamura, H., Kitano, H., Kollias, G., Krishnan, S. P. T., Kruger, A., Kummerfeld, S. K., Kurochkin, I. V., Lareau, L. F., Lazarevic, D., Lipovich, L., Liu, J., Liuni, S., McWilliam, S., Babu, M. Madan, Madera, M., Marchionni, L., Matsuda, H., Matsuzawa, S., Miki, H., Mignone, F., Miyake, S., Morris, K., Mottagui-Tabar, S., Mulder, N., Nakano, N., Nakauchi, H., Ng, P., Nilsson, R., Nishiguchi, S., Nishikawa, S., Nori, F., Ohara, O., Okazaki, Y., Orlando, V., Pang, K. C., Pavan, W. J., Pavesi, G., Pesole, G., Petrovsky, N., Piazza, S., Reed, J., Reid, J. F., Ring, B. Z., Ringwald, M., Rost, B., Ruan, Y., Salzberg, S. L., Sandelin, A., Schneider, C., Schöbach, C., Sekiguchi, K., Semple, C. A. M., Seno, S., Sessa, L., Sheng, Y., Shibata, Y., Shimada, H., Shimada, K., Silva, D., Sinclair, B., Sperling, S., Stupka, E., Sugiura, K., Sultana, R., Takenaka, Y., Taki, K., Tammoja, K., Tan, S. L., Tang, S., Taylor, M. S., Tegner, J., Teichmann, S. A., Ueda, H. R., van Nimwegen, E., Verardo, R., Wei, C. L., Yagi, K., Yamanishi, H., Zabarovsky, E., Zhu, S., Zimmer, A., Hide, W., Bult, C., Grimmond, S. M., Teasdale, R. D., Liu, E. T., Brusic, V., Quackenbush, J., Wahlestedt, C., Mattick, J. S., Hume, D. A., Kai, C., Sasaki, D., Tomaru, Y., Fukuda, S., Kanamori-Katayama, M., Suzuki, M., Aoki, J., Arakawa, T., Iida, J., Imamura, K., Itoh, M., Kato, T., Kawaji, H., Kawagashira, N., Kawashima, T., Kojima, M., Kondo, S., Konno, H., Nakano, K., Ninomiya, N., Nishio, T., Okada, M., Plessy, C., Shibata, K., Shiraki, T., Suzuki, S., Tagami, M., Waki, K., Watahiki, A., Okamura-Oho, Y., Suzuki, H., and Kawai, J.

Published
2005

3. Intracellular Transport and Kinesin Superfamily Proteins: Structure, Function and Dynamics

Author

Hirokawa, N., Takemura, R., Beig, R., editor, Beiglböck, W., editor, Domcke, W., editor, Englert, B.-G., editor, Frisch, U., editor, Hänggi, P., editor, Hasinger, G., editor, Hepp, K., editor, Hillebrandt, W., editor, Imboden, D., editor, Jaffe, R. L., editor, Lipowsky, R., editor, Löhneysen, H. v., editor, Ojima, I., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Wess, J., editor, Zittartz, J., editor, Linke, Heiner, editor, and Månsson, Alf, editor

Published
2007
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10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

Author

Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bono, H., Kondo, S., Nikaido, I., Osato, N., Saito, R., Suzuki, H., Yamanaka, I., Kiyosawa, H., Yagi, K., Tomaru, Y., Hasegawa, Y., Nogami, A., Schonbach, C., Gojobori, T., Baldarelli, R., Hill, D. P., Bult, C., Hume, D. A., Quackenbush, J., Schriml, L. M., Kanapin, A., Matsuda, H., Batalov, S., Beisel, K. W., Blake, J. A., Bradt, D., Brusic, V., Chothia, C., Corbani, L. E., Cousins, S., Dalla, E., Dragani, T. A., Fletcher, C. F., Forrest, A., Frazer, K. S., Gaasterland, T., Gariboldi, M., Gissi, C., Godzik, A., Gough, J., Grimmond, S., Gustincich, S., Hirokawa, N., Jackson, I. J., Jarvis, E. D., Kanai, A., Kawaji, H., Kawasawa, Y., Kedzierski, R. M., King, B. L., Konagaya, A., Kurochkin, I. V., Lee, Y., Lenhard, B., Lyons, P. A., Maglott, D. R., Maltais, L., Marchionni, L., McKenzie, L., Miki, H., Nagashima, T., Numata, K., Okido, T., Pavan, W. J., Pertea, G., Pesole, G., Petrovsky, N., Pillai, R., Pontius, J. U., Qi, D., Ramachandran, S., Ravasi, T., Reed, J. C., Reed, D. J., Reid, J., Ring, B. Z., Ringwald, M., Sandelin, A., Schneider, C., Semple, C. A. M., Setou, M., Shimada, K., Sultana, R., Takenaka, Y., Taylor, M. S., Teasdale, R. D., Tomita, M., Verardo, R., Wagner, L., Wahlestedt, C., Wang, Y., Watanabe, Y., Wells, C., Wilming, L. G., Wynshaw-Boris, A., Yanagisawa, M., Yang, I., Yang, L., Yuan, Z., Zavolan, M., Zhu, Y., Zimmer, A., Carninci, P., Hayatsu, N., Hirozane-Kishikawa, T., Konno, H., Nakamura, M., Sakazume, N., Sato, K., Shiraki, T., Waki, K., Kawai, J., Aizawa, K., Arakawa, T., Fukuda, S., Hara, A., Hashizume, W., Imotani, K., Ishii, Y., Itoh, M., Kagawa, I., Miyazaki, A., Sakai, K., Sasaki, D., Shibata, K., Shinagawa, A., Yasunishi, A., Yoshino, M., Waterston, R., Lander, E. S., Rogers, J., Birney, E., and Hayashizaki, Y.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team*; FANTOM Consortium:; Y. Okazaki [1, 2]; M. Furuno [1]; T. Kasukawa [1, 3]; J. [...]

Published
2002
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11. Oligomeric tubulin in large transporting complex is transported via kinesin in squid giant axons

Author

Terada, S., Kinjo, M., and Hirokawa, N.

Subjects
Cytochemistry -- Research, Axons -- Physiological aspects, Cytosol -- Physiological aspects, Tubulins -- Physiological aspects, Squids -- Physiological aspects, Biological sciences
Abstract

Oligomeric tubulin in large transporting complex has been found to be transported via kinesin in squid giant axons. The movement of fluorescence was monitored with confocal laser scanning microscopy and fluorescence correlation spectroscopy after injection of the axons with fluorescence-labeled tubulin

Published
2000

16. Altered microtubule organization in small-calibre axons of mice lacking tau protein

Author

Harada, A., Oguchi, K., Okabe, S., Kuno, J., Terada, S., Ohshima, T., Sato-Yoshitake, R., Takei, Y., Noda, T., and Hirokawa, N.

Subjects
Tubulins -- Research, Axons -- Research, Mice -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Gene tau-encoding protein Tau is vital for neuronal cell morphogenesis, as tau is a major microtubule (MT)-associated protein that stabilizes and organizes microtubules by its microtubule-binding and tubulin-polymerizing activities. In large-caliber axons, loss of tau does not affect MT stability, whereas in small-caliber axons, the loss of tau greatly affects the MT stability. A microtubule-associated protein 1A executes the function of tau in large-caliber axons.

Published
1994

17. Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

Author

Chen, J., Kanai, Y., Cowan, N.J., and Hirokawa, N.

Subjects
Tubulins -- Research, Microtubules -- Research, Neurons -- Research, Dendrites -- Research, Axons -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Dendrites and axons are processes of neurons which contain microtubules and microtubule-associated proteins (MAPs). Insect ovarian Sf9 cells were used to study the effect on their microtubule morphology and arrangement of the expression of the three MAPs: MAP2, MAP2C and tau. The Sf9 cells were caused to synthesize these proteins by infection with a virus containing recombinant sequence encoding them. Cells expressing MAP2 were found to have microtubules arranged as they are in dendrites while cells expressing MAP2C and tau were found to have microtubules spaced as in axons.

Published
1992

24. Gene expression alterations in tau-deficient mice

Author

Oyama F., Kotliarova, S.E., Harada, A., Ito, M., Ueyama, Y., Hirokawa, N., Nukina, N., and Ihara, Y.

Subjects
Human genetics -- Research, Genetic disorders -- Research, Kaons -- Genetic aspects, Inflammation -- Physiological aspects, Biological sciences
Published
2001

25. KIF2beta , a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation

Author

Santama, Niovi, Krijnse-Ĺocker, J., Griffiths, G., Noda, Y., Hirokawa, N., Dotti, C. G., and Santama, Niovi [0000-0002-8370-8674]

Subjects
Intracellular Fluid, nervous system development, hippocampus, Cellular differentiation, complementary DNA, Kinesins, animal cell, Motor proteins, alternative rna splicing, kinesin, Microtubules, Hippocampus, fibroblast, Mice, newborn, animal, genetics, membrane protein, rat, Cells, Cultured, Neurons, General Neuroscience, article, Gene Expression Regulation, Developmental, Cell Differentiation, gene expression regulation, 3T3 Cells, Lamp-1,2, Immunohistochemistry, Kif2b protein, mouse, Cell biology, Isoenzymes, medicine.anatomical_structure, Endocytic vesicle, priority journal, immunohistochemistry, lysosome, protein transport, Kinesin, nerve cell, isoenzyme, Research Article, DNA, Complementary, messenger rna, Endosome, enzymology, Molecular Sequence Data, DNA sequence, embryo, Biology, General Biochemistry, Genetics and Molecular Biology, intracellular fluid, detergent, Microtubule, Lysosome, medicine, Animals, controlled study, cell strain 3T3, Amino Acid Sequence, immunofluorescence, protein expression, endosome, Molecular Biology, mouse, centrifugation, Cell Nucleus, cell culture, nonhuman, electron microscopy, Base Sequence, General Immunology and Microbiology, isolation and purification, cell nucleus, nucleotide sequence, Sequence Analysis, DNA, Fibroblasts, protein family, amino acid sequence, cell differentiation, Membrane protein, molecular genetics, physiology, Axoplasmic transport, pathology, genetic transfection, biosynthesis, Lysosomes, metabolism
Abstract

Lysosomes concentrate juxtanuclearly in the region around the microtubule-organizing center by interaction with microtubules. Different experimental and physiological conditions can induce these organelles to move to the cell periphery by a mechanism implying a plus-end-directed microtubule-motor protein (a kinesin-like motor). The responsible kinesin-superfamily protein, however, is unknown. We have identified a new mouse isoform of the kinesin superfamily, KIF2β, an alternatively spliced isoform of the known, neuronal kinesin, KIF2. Developmental expression pattern and cell-type analysis in vivo and in vitro reveal that KIF2β is abundant at early developmental stages of the hippocampus but is then downregulated in differentiated neuronal cells, and it is mainly or uniquely expressed in non-neuronal cells while KIF2 remains exclusively neuronal. Electron microscopy of mouse fibroblasts and immunofluorescence of KIF2β-transiently-transfected fibroblasts show KIF2 and KIF2β primarily associated with lysosomes, and this association can be disrupted by detergent treatment. In KIF2β-overexpressing cells, lysosomes (labeled with anti-lysosome-associated membrane protein-1) become abnormally large and peripherally located at some distance from their usual perinuclear positions. Overexpression of KIF2 or KIF2β does not change the size or distribution of early, late and recycling endosomes nor does overexpression of different kinesin superfamily proteins result in changes in lysosome size or positioning. These results implicate KIF2β as a motor responsible for the peripheral translocation of lysosomes. 17 5855 5867 Cited By :50

Published
1998

35. Neuroendocrinology

Author

Swaab, D.F., Lucassen, P.J., Binder, M.D., Hirokawa, N., Windhorst, U., and Structural and Functional Plasticity of the nervous system (SILS, FNWI)

Published
2009

37. Neuroendocrinology of psychiatric disorders

Author

Bao, A.M, Lucassen, P.J., Swaab, D.F., Binder, M.D., Hirokawa, N., Windhorst, U., and Structural and Functional Plasticity of the nervous system (SILS, FNWI)

Published
2009

38. Neuroendocrinology of tumors

Author

Swaab, D.F., Lucassen, P.J., Binder, M.D., Hirokawa, N., Windhorst, U., Nederlands Herseninstituut (NIN), and Structural and Functional Plasticity of the nervous system (SILS, FNWI)

Published
2009

44. Hypothalamo-neurohypophysial system

Author

Swaab, D.F., Lucassen, P.J., Binder, M.D., Hirokawa, N., Windhorst, U., and Structural and Functional Plasticity of the nervous system (SILS, FNWI)

Published
2009

45. Drinking disorders and osmoregulation

Author

Swaab, D.F., Lucassen, P.J., Binder, M.D., Hirokawa, N., Windhorst, U., Structural and Functional Plasticity of the nervous system (SILS, FNWI), and Nederlands Herseninstituut (NIN)

Published
2009

46. Cortical development - Disorders

Author

Lucassen, P.J., Boekhoorn, K., Francis, F., Binder, M.D., Hirokawa, N., Windhorst, U., and Structural and Functional Plasticity of the nervous system (SILS, FNWI)

Published
2009

47. Muscle

Author

Heckman, C.J., Perreault, E.J., Sandercock, T.G., Maas, H., Binder, M.D., Hirokawa, N., Windhors, U., Kinesiology, and Research Institute MOVE

Published
2009

48. Neuroendocrinology of eating disorders

Author

Swaab, D.F., Lucassen, P.J., Binder, M.D., Hirokawa, N., Windhorst, U., Nederlands Herseninstituut (NIN), and Structural and Functional Plasticity of the nervous system (SILS, FNWI)

Published
2009

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