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Your search keyword '"Hiroka Komatsu"' showing total 2 results
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2 results on '"Hiroka Komatsu"'

1. Umbilical Cord Blood Transplantation for Myelodysplastic Syndromes with Donor-Specific Anti-HLA Antibodies against HLA-DP.

Author

Yusuke Uchibori, Koichi Onodera, Yasushi Onishi, Hiroka Komatsu, Kenta Takenaka, Yoshihiro Narumi, Tatsuya Watanabe, Hiroshi Nakamura, Kazuki Sakurai, Kazuki Hashimoto, Kyoko Inokura, Satoshi Ichikawa, Noriko Fukuhara, Hisayuki Yokoyama, and Hideo Harigae

Abstract

The presence of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) against anti-HLA-A, -B, -C, and -DRB1 in HLA-mismatched hematopoietic stem cell transplantation (HSCT) is associated with graft failure. DSAs against HLA-A, -B, -C, and -DRB1 with a mean fluorescence intensity (MFI) of greater than > 1,000 was shown to increase the risk of graft failure in single-unit umbilical cord blood transplantation (UCBT). Nevertheless, the impact of DSAs against HLA-DP or -DQ on transplantation outcomes is not fully understood. In this report, we present a case of UCBT in a patient with myelodysplastic syndrome who was positive for DSAs against HLA-DP with MFI of 1,263 before UCBT but successfully achieved neutrophil engraftment. If HLA-DP or -DQ is mismatched in UCBT, evaluating DSAs against HLA-DP or -DQ is crucial to avoid graft failure. However, the criteria for DSAs against HLA-A, -B, -C, and -DRB1 may not be directly applicable to those against HLA-DP or -DQ. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Migratory Aortitis Associated with Granulocyte-colony-stimulating Factor

Author

Hideo Harigae, Hiroshi Fujii, Hiroko Sato, Tomonori Ishii, Hiroka Komatsu, and Tsuyoshi Shirai

Subjects
Aortic arch, Pathology, medicine.medical_specialty, Filgrastim, medicine.medical_treatment, migratory aortitis, Aorta, Thoracic, Case Report, 030204 cardiovascular system & hematology, chemotherapy, Polyethylene Glycols, 03 medical and health sciences, 0302 clinical medicine, medicine.artery, Internal Medicine, Medicine, Humans, Aortitis, Aged, granulocyte-colony-stimulating factor, Chemotherapy, business.industry, Immunosuppression, General Medicine, medicine.disease, Granulocyte colony-stimulating factor, Pancreatic Neoplasms, Descending aorta, 030211 gastroenterology & hepatology, Female, Neoplasm Recurrence, Local, business, Pegfilgrastim, medicine.drug, Granulocytes
Abstract

We herein report a case of migratory aortitis after the administration of granulocyte-colony-stimulating factor (G-CSF) to a 65-year-old woman with a history of pancreatic cancer. She was being administered pegfilgrastim and developed aortitis around the aortic arch. Although it resolved within two weeks, she again developed aortitis around the descending aorta, presenting as migratory aortitis, after pegfilgrastim was resumed. We further experienced three additional cases of G-CSF-induced aortitis that also showed spontaneous resolution, suggesting no or short-term use of immunosuppression. Aortitis due to G-CSF can present as migratory aortitis, since aortitis can quickly resolve and inflammation can recur at a different location.

Published
2020

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