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1. Human Breast Milk Exosomes: Affecting Factors, Their Possible Health Outcomes, and Future Directions in Dietetics.

Author

Çelik, Elif, Cemali, Özge, Şahin, Teslime Özge, Deveci, Gülsüm, Biçer, Nihan Çakır, Hirfanoğlu, İbrahim Murat, Ağagündüz, Duygu, and Budán, Ferenc

Abstract

Background: Human breast milk is a complex biological fluid containing multifaceted biological compounds that boost immune and metabolic system development that support the short- and long-term health of newborns. Recent literature suggests that human breast milk is a substantial source of nutrients, bioactive molecules, and exosomes. Objectives: This review examines the factors influencing exosomes noted in human milk and the impacts of exosomes on infant health. Furthermore, it discusses potential future prospects for exosome research in dietetics. Methods: Through a narrative review of the existing literature, we focused on exosomes in breast milk, exosome components and their potential impact on exosome health. Results: Exosomes are single-membrane extracellular vesicles of endosomal origin, with an approximate radius of 20–200 nm. They are natural messengers that cells secrete to transport a wide range of diverse cargoes, including deoxyribonucleic acid, ribonucleic acid, proteins, and lipids between various cells. Some studies have reported that the components noted in exosomes in human breast milk could be transferred to the infant and cause epigenetic changes. Thus, it can affect gene expression and cellular event regulation in several tissues. Conclusions: In this manner, exosomes are associated with several pathways, including the immune system, oxidative stress, and cell cycle, and they can affect the short- and long-term health of infants. However, there is still much to learn about the functions, effectiveness, and certain impacts on the health of human breast milk exosomes. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Novel Compound Heterozygous Mutations of TGM1 Gene Identified in a Turkish Collodion Baby Diagnosed with Non-Bullous Congenital Ichthyosiform Erythroderma

Author

Gülnerman, Elif Keleş, primary, Hanedan, Nurcan, additional, Akillioglu, Merve, additional, Kayhan, Gülsüm, additional, Adişen, Esra, additional, Erdem, Özlem, additional, Hirfanoğlu, İbrahim Murat, additional, Ergenekon, Ebru, additional, Önal, Eray Esra, additional, Türkyilmaz, Canan, additional, and Koç, Esin, additional

Published
2023
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5. Neonatal Resuscitation Practices in Turkey: A Survey of the Turkish Neonatal Society and the Union of European Neonatal and Perinatal Societies.

Author

Okulu, Emel, Koç, Esin, Erdeve, Ömer, Akdağ, Arzu, Aktaş, Selma, Aydemir, Özge, Aygün, Canan, Bayraktar, Bilge Tanyeri, Cebeci, Burcu, Çelik, Hasan Tolga, Çelik, Kıymet, Engür, Defne, Ertuğrul, Sabahattin, Fettah, Nurdan Dinlen, Gültekin, Nazlı Dilay, Taviloğlu Güçyetmez, Zatigül Şafak, Gülen, Pelin, Hirfanoğlu, İbrahim Murat, İnce, Zeynep, and Kader, Şebnem

Subjects
THERAPEUTIC use of nitric oxide, PROFESSIONAL practice, INDUCED hypothermia, NEONATAL intensive care, SPECIALTY hospitals, NASAL cannula, CROSS-sectional method, CONTINUOUS positive airway pressure, POSITIVE end-expiratory pressure, HOSPITAL birthing centers, FISHER exact test, ARTIFICIAL respiration, PEARSON correlation (Statistics), QUESTIONNAIRES, CHI-squared test, DESCRIPTIVE statistics, INFANT mortality, RESUSCITATION, PRENATAL care, DATA analysis software
Abstract

Objective: Optimal care in the delivery room is important to decrease neonatal morbidity and mortality. We aimed to evaluate neonatal resuscitation practices in Turkish centers. Materials and Methods: A cross-sectional survey consisted of a 91-item questionnaire focused on delivery room practices in neonatal resuscitation and was sent to 50 Turkish centers. Hospitals with <2500 and those with ≥2500 births/year were compared. Results: In 2018, approximately 240 000 births occurred at participating hospitals with a median of 2630 births/year. Participating hospitals were able to provide nasal continuous-positive airway-pressure/high-flow nasal cannula, mechanical ventilation, high-frequency oscillatory ventilation, inhaled nitric oxide, and therapeutic hypothermia similarly. Antenatal counseling was routinely performed on parents at 56% of all centers. A resuscitation team was present at 72% of deliveries. Umbilical cord management for both term and preterm infants was similar between centers. The rate of delayed cord clamping was approximately 60% in term and late preterm infants. Thermal management for preterm infants (<32 weeks) was similar. Hospitals had appropriate equipment with similar rates of interventions and management, except continuous-positive-airway-pressure and positive-end-expiratory-pressure levels (cmH2O) used in preterm infants (P = .021, and P = .032). Ethical and educational aspects were also similar. Conclusions: This survey provided information on neonatal resuscitation practices in a sample of hospitals from all regions of Turkey and allowed us to see weaknesses in some fields. Although adherence to the guidelines was high among centers, further implementations are required in the areas of antenatal counseling, cord management, and circulation assessment in the delivery room. [ABSTRACT FROM AUTHOR]

Published
2023
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14. The prevalence and diagnostic criteria of health-care associated infections in neonatal intensive care units in Turkey: A multicenter point- prevalence study

Author

Bedir Demirdağ, Tuğba, primary, Koç, Esin, additional, Tezer, Hasan, additional, Oğuz, Suna, additional, Satar, Mehmet, additional, Sağlam, Özge, additional, Uygun, Saime Sündüz, additional, Önal, Esra, additional, Hirfanoğlu, İbrahim Murat, additional, Tekgündüz, Kadir, additional, Oygür, Nihal, additional, Bülbül, Ali, additional, Zübarioğlu, Adil Umut, additional, Üstün, Nuran, additional, Ünal, Sezin, additional, Aygün, Canan, additional, Saygılı Karagöl, Belma, additional, Zenciroğlu, Ayşegül, additional, Öncel, M. Yekta, additional, Çakıl Sağlık, Adviye, additional, Okulu, Emel, additional, Terek, Demet, additional, Narlı, Nejat, additional, Aliefendioğlu, Didem, additional, Gürsoy, Tuğba, additional, Ünal, Sevim, additional, Kaynak Türkmen, Münevver, additional, Kaya Narter, Fatma, additional, Aladağ Çiftdemir, Nükhet, additional, Beken, Serdar, additional, Çakır, Salih Çağrı, additional, Yiğit, Şule, additional, Çoban, Asuman, additional, Ecevit, Ayse, additional, Çelik, Yalçın, additional, and Kulalı, Ferit, additional

Published
2021
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17. Breastfeeding In Baby-Friendly NICU and Our Experience

Author

TÜRKYILMAZ, CANAN, KELEŞ, ELİF, KÜREKÇİ, NURTEN, EROĞLU, DONE, AKTAŞ, EMEL, GÖKÇAY, BAŞAK, KENAR, AYTAÇ, HIRFANOĞLU, İBRAHİM MURAT, ONAL, ESRA, ERGENEKON, NURİYE EBRU, and KOC, ESIN

Published
2019

18. Breastfeeding in Baby Friendly NICU and Our Experiences

Author

ONAL, ESRA, canbeyli, fatma, KELEŞ, ELİF, ERGENEKON, NURİYE EBRU, KOC, ESIN, HIRFANOĞLU, İBRAHİM MURAT, KAYA GÜRSOY, BAŞAK, KENAR, AYTAÇ, BAŞ, MEDİNE MÜNEVVER, TAŞ, MELDA, TOKGÖZ, SEMİHA, and TÜRKYILMAZ, CANAN

Published
2019

22. Early neonatal outcomes of very-low-birth-weight infants in Turkey: a prospective multicenter study of the Turkish Neonatal Society

Author

Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Koç, Esin; Demirel, Nihal; Baş, Ahmet Yağmur; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunc, Turan; Sarı, Fatma Nur; Karatekin, Güner; Özdemir, Ramazan; Altunhan, Hüseyin; Çetinkaya, Merih; Özcan, Beyza; Özkiraz, Servet; Çalkavur, Sebnem; Tekgündüz, Kadir Şerafettin; Taştekin, Ayhan; Özlü, Ferda; Özyurt, Banu Mutlu; Özdemir, Ahmet; Çetinkaya, Bilin; Demirelli, Yaşar; Köklü, Esad; Çelik, Ülker; Tarakçı, Nuriye; Armangil, Didem; Okulu, Emel; Narter, Fatma; Mutlu, Birgul; Mert, Mustafa Kurthan; Bülbül, Ali; Asker, Hüseyin Selim; Uygur, ÖzgÜn; Uslu, İlker Sait; Ertuğrul, Sabahattin; Aydemir, Cumhur; Çelik, Hasan Tolga; Küçüktaşçı, Kazım; Arslan, Selda; Ergin, Hacer; Zenciroğlu, Aysegül; Yurttutan, Sadık; Orman, Ayşen; Tuncer, Oğuz; Yaşa, Beril; Acunas, Betül; Takci, Şahin; Gökmen, Zeynel; Özkan, Hilal; Cömert, Serdar; Üstün, Nuran; Mutlu, Mehmet; Bayraktar, Bilge Tanyeri; Bilgin, Leyla; Tuzun, Funda; Aydemir, Özge; Akdağ, Arzu; Memisoğlu, Aslı; Can, Emrah; Terek, Demet; Beken, Serdar; Turan, Özden; Güzoğlu, Nilüfer; Örs, Rahmi; Kale, Yusuf; Hekimoğlu, Berna; Aylanc, Hakan; Eroğlu, Funda; Şahin, Suzan; Konak, Murat; Sarıcı, Dilek; Kılıç, İlknur; Hakan, Nilay, School of Medicine, Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Koç, Esin; Demirel, Nihal; Baş, Ahmet Yağmur; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunc, Turan; Sarı, Fatma Nur; Karatekin, Güner; Özdemir, Ramazan; Altunhan, Hüseyin; Çetinkaya, Merih; Özcan, Beyza; Özkiraz, Servet; Çalkavur, Sebnem; Tekgündüz, Kadir Şerafettin; Taştekin, Ayhan; Özlü, Ferda; Özyurt, Banu Mutlu; Özdemir, Ahmet; Çetinkaya, Bilin; Demirelli, Yaşar; Köklü, Esad; Çelik, Ülker; Tarakçı, Nuriye; Armangil, Didem; Okulu, Emel; Narter, Fatma; Mutlu, Birgul; Mert, Mustafa Kurthan; Bülbül, Ali; Asker, Hüseyin Selim; Uygur, ÖzgÜn; Uslu, İlker Sait; Ertuğrul, Sabahattin; Aydemir, Cumhur; Çelik, Hasan Tolga; Küçüktaşçı, Kazım; Arslan, Selda; Ergin, Hacer; Zenciroğlu, Aysegül; Yurttutan, Sadık; Orman, Ayşen; Tuncer, Oğuz; Yaşa, Beril; Acunas, Betül; Takci, Şahin; Gökmen, Zeynel; Özkan, Hilal; Cömert, Serdar; Üstün, Nuran; Mutlu, Mehmet; Bayraktar, Bilge Tanyeri; Bilgin, Leyla; Tuzun, Funda; Aydemir, Özge; Akdağ, Arzu; Memisoğlu, Aslı; Can, Emrah; Terek, Demet; Beken, Serdar; Turan, Özden; Güzoğlu, Nilüfer; Örs, Rahmi; Kale, Yusuf; Hekimoğlu, Berna; Aylanc, Hakan; Eroğlu, Funda; Şahin, Suzan; Konak, Murat; Sarıcı, Dilek; Kılıç, İlknur; Hakan, Nilay, and School of Medicine

Abstract

Objective: to investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey. Material and methods: a prospective cohort study was performed between April 1, 2016 and April 30, 2017. The study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of.1500 g were collected for infants who survived. Results: data from 69 NICUs were obtained. The mean birth weight and gestational age were 1137 +/- 245 g and 29 +/- 2.4 weeks, respectively. During the study period, 78% of VLBW infants survived to discharge and 48% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7% of infants, necrotizing enterocolitis in 9.1%, blood culture proven late-onset sepsis (LOS) in 21.1%, blood culture negative LOS in 21.3%, severe intraventricular hemorrhage in 5.4% and severe retinopathy of prematurity in 11.1%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8% of infants. Antenatal steroids were administered to 42.9% of mothers. Conclusion: the present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs., Turkish Neonatal Society

Published
2019

23. Body fat in NICU and longterm neurodevelopment

Author

KOÇ, ESİN, TÜRKYILMAZ, CANAN, ülger, meral, HIRFANOĞLU, İBRAHİM MURAT, ALTUNTAŞ, NİLGÜN, AKTAŞ, SELMA, KAZANCI, EBRU, ÜNAL, SEZİN, KULALI, FERİT, BEKEN, SERDAR, ERGENEKON, NURİYE EBRU, soysal, şebnem, and ATALAY, YILDIZ

Published
2018

24. Türkiye’de 31 yenidoğan yoğun bakım ünitesinde nozokomiyal enfeksiyon sıklığı: nokta prevalans çalışması

Author

KOÇ, ESİN, ÖNAL, ERAY ESRA, HİRFANOĞLU, İBRAHİM MURAT, TEKGÜNDÜZ, KADİR ŞERAFETTİN, OYGÜR, NİHAL, BÜLBÜL, ALİ, ZÜBARİOĞLU, ADİL UMUT, ÜSTÜN, NURAN, ÜNAL, SEZİN, AYGÜN, HASİBE CANAN, SAYGILI KARAGÖL, BELMA, ZENCİROĞLU, AYŞEGÜL, ÖNCEL, MEHMET YEKTA, ÇAKIL SAĞLIK, ADVİYE, OKULU, EMEL, TEREK, DEMET, NARLI, NEJAT, ALİEFENDİOĞLU, DİDEM, GÜRSOY, TUĞBA, ÜNAL, SEVİM, KAYNAK TÜRKMEN, MÜNEVVER, KAYA NARTER, FATMA, ALADAĞ ÇİFTDEMİR, NÜKHET, BEKEN, SERDAR, ÇAKIR, SALİH ÇAĞRI, YİĞİT, ŞULE, ÇOBAN, EMİNE ASUMAN, ECEVİT, AYŞE NUR, ÇELİK, YALÇIN, KULALI, FERİT, SATAR, MEHMET, SAĞLAM, ÖZGE, UYGUN, SAİME SÜNDÜS, BEDİR DEMİRDAĞ, TUĞBA, TEZER, HASAN, and OĞUZ, ŞERİFE SUNA

Published
2018

25. Türkiye’de 31 yenidoğan yoğun bakım ünitesine nozokomiyal enfeksiyon sıklığı: nokta prevelans çalışması

Author

ÜSTÜN, NURAN, BÜLBÜL, ALİ, TEZER, HASAN, KOÇ, ESİN, BEDİR DEMİRAĞ, TUĞBA, OYGÜR, NİHAL, ECEVİT, AYŞE NUR, YİĞİT, ŞULE, BEKEN, SERDAR, ALADAĞ ÇİFTDEMİR, NÜKHET, KAYNAK TÜRKMEN, MÜNEVVER, ÜNAL, SEVİM, GÜRSOY, TUĞBA, ALİEFENDİOĞLU, DİDEM, NARLI, NEJAT, TEREK, DEMET, OKULU, EMEL, ÖNCEL, MEHMET YEKTA, ZENCİROĞLU, AYŞEGÜL, TEKGÜNDÜZ, KADİR ŞERAFETTİN, AYGÜN, HASİBE CANAN, HİRFANOĞLU, İBRAHİM MURAT, ÖNAL, ERAY ESRA, SAĞLAM, ÖZGE, SATAR, MEHMET, OĞUZ, SUNA, ÇELİK, YALÇIN, and ÇOBAN, EMİNE ASUMAN

Published
2018

26. Türkiye’de 31 yenidoğan yoğun bakım ünitesine nozokomiyal enfeksiyon sıklığı: nokta prevelans çalışması

Author

SAĞLAM, ÖZGE, KULALI, FERİT, ÇELİK, YALÇIN, ECEVİT, AYŞE NUR, ÇOBAN, EMİNE ASUMAN, YİĞİT, ŞULE, ÇAKIR, SALİH ÇAĞRI, BEKEN, SERDAR, ALADAĞ ÇİFTDEMİR, NÜKHET, KAYA NARTER, FATMA, KAYNAK TÜRKMEN, MÜNEVVER, ÜNAL, SEVİM, GÜRSOY, TUĞBA, ALİEFENDİOĞLU, DİDEM, NARLI, NEJAT, TEREK, DEMET, OKULU, EMEL, ÇAKIL SAĞLIK, ADVİYE, ÖNCEL, MEHMET YEKTA, ZENCİROĞLU, AYŞEGÜL, SAYGILI KARAGÖL, BELMA, AYGÜN, HASİBE CANAN, ÜNAL, SEZİN, ÜSTÜN, NURAN, ZÜBARİOĞLU, ADİL UMUT, BÜLBÜL, ALİ, OYGÜR, NİHAL, TEKGÜNDÜZ, KADİR ŞERAFETTİN, HİRFANOĞLU, İBRAHİM MURAT, ÖNAL, ERAY ESRA, UYGUN, SAİME SÜNDÜS, SATAR, MEHMET, SUNA, OĞUZ, TEZER, HASAN, KOÇ, ESİN, and DEMİRDAĞ, TUĞBA

Published
2018

28. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units

Author

Uludağ, Günay (ORCID & YÖK ID 175586); Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Baş, Ahmet Yağmur; Demirel, Nihal; Koç, Esin; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunç, Turan; Sarı, Fatma Nur; Karatekin, Güner; Köklü, Esad; Altunhan, Hüseyin; Turgut, Hatice; Narter, Fatma; Tarakçı, Nuriye; Tekgündüz, Kadir Şerafettin; Özkiraz, Servet; Aydemir, Cumhur; Özdemir, Ahmet; Çetinkaya, Bilin; Kazancı, Ebru; Taştekin, Ayhan; Calkavur, Şebnem; Özyurt, Banu Mutlu; Demirelli, Yaşar; Asker, Hüseyin Selim; Mutlu, Birgul; Uygur, Özgün; Özkan, Hilal; Armangil, Didem; Özlü, Ferda; Mert, Mustafa Kurthan; Ergin, Hacer; Özcan, Beyza; Baş, Evrim Kıray; Okulu, Emel; Acunas, Betül; Çelik, Ülker; Uslu, Sait İlker; Mutlu, Mehmet; Demir, Nihat; Eroğlu, Funda; Gökmen, Zeynel; Beken, Serdar; Bayraktar, Bilge Tanyeri; Hakan, Nilay; Küçüktaşçı, Kazım; Orman, Ayşen; Cömert, Serdar; Ertuğrul, Sabahattin; Üstün, Nuran; Şahin, Özlem; Terek, Demet; Kale, Yusuf; Konak, Murat; Yurttutan, Sadık; Aydemir, Özge; Zenciroğlu, Aysegül; Sarıcı, Dilek; Güzoğlu, Nilüfer; Hamilçıkan, Şahin; Tüzün, Funda; Örs, Rahmi; Arslan, Selda; Akdağ, Arzu; Memişoğlu, Aslı; Yasa, Beril; Hekimoğlu, Berna; Turan, Özden; Aylanc, Hakan; Takçı, Şahin; Çelik, Tolga; Şahin, Suzan; Kılıç, İlknur; Kara, Caner; Tunay, Zuhal Özen; Çelik, Gökhan; Gözen, İbrahim; Satırtav, Günhal; Polat, Nihat; Oral, Ayşe Yeşim; Tokgöz, Mine; Keleş, Sadullah; Bilgin, Burak; Uğurbaş, Silay Cantürk; Karaca, Çağatay; Keşkek, Nedime Şahinoğlu; Ekinci, Dilbade Yıldız; Balcı, Özlem; Altan, Emir Volkan; Bakbak, Sevda; Ceylan, Nihan Aksu; Kimyon, Sabit; Alyamaç, Günay; Türe, Gamze; Yıldız, Meral; Çalış, Feyza; Sızmaz, Selçuk; Sukgen, Emine; Çetin, Ebru Nevin; Özçimen, Muammer; Demir, Semra Tiryaki; Atila, Huban; Özal, Altan; Tufaner, Gökhan; Yücel, Özlem Eski; Kola, Mehmet; Seven, Erbil; Özdek, Şengül; Durukan, Ali Hakan; Kal, Ali; Çelebi, Ali Riza Cenk; Koytak, İbrahim Arif; Alaçamlı, Göksu; Esme, Arif; Çatak, Onur; Perente, İrfan; Şahin, Alparslan; Akçakaya, Aylin Ardagil; Kıray, Gülünay; Nalçacı, Serhat; Aksoy, Ümit; Bakbak, Ber, School of Medicine, Department of Internal Medicine, Uludağ, Günay (ORCID & YÖK ID 175586); Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Baş, Ahmet Yağmur; Demirel, Nihal; Koç, Esin; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunç, Turan; Sarı, Fatma Nur; Karatekin, Güner; Köklü, Esad; Altunhan, Hüseyin; Turgut, Hatice; Narter, Fatma; Tarakçı, Nuriye; Tekgündüz, Kadir Şerafettin; Özkiraz, Servet; Aydemir, Cumhur; Özdemir, Ahmet; Çetinkaya, Bilin; Kazancı, Ebru; Taştekin, Ayhan; Calkavur, Şebnem; Özyurt, Banu Mutlu; Demirelli, Yaşar; Asker, Hüseyin Selim; Mutlu, Birgul; Uygur, Özgün; Özkan, Hilal; Armangil, Didem; Özlü, Ferda; Mert, Mustafa Kurthan; Ergin, Hacer; Özcan, Beyza; Baş, Evrim Kıray; Okulu, Emel; Acunas, Betül; Çelik, Ülker; Uslu, Sait İlker; Mutlu, Mehmet; Demir, Nihat; Eroğlu, Funda; Gökmen, Zeynel; Beken, Serdar; Bayraktar, Bilge Tanyeri; Hakan, Nilay; Küçüktaşçı, Kazım; Orman, Ayşen; Cömert, Serdar; Ertuğrul, Sabahattin; Üstün, Nuran; Şahin, Özlem; Terek, Demet; Kale, Yusuf; Konak, Murat; Yurttutan, Sadık; Aydemir, Özge; Zenciroğlu, Aysegül; Sarıcı, Dilek; Güzoğlu, Nilüfer; Hamilçıkan, Şahin; Tüzün, Funda; Örs, Rahmi; Arslan, Selda; Akdağ, Arzu; Memişoğlu, Aslı; Yasa, Beril; Hekimoğlu, Berna; Turan, Özden; Aylanc, Hakan; Takçı, Şahin; Çelik, Tolga; Şahin, Suzan; Kılıç, İlknur; Kara, Caner; Tunay, Zuhal Özen; Çelik, Gökhan; Gözen, İbrahim; Satırtav, Günhal; Polat, Nihat; Oral, Ayşe Yeşim; Tokgöz, Mine; Keleş, Sadullah; Bilgin, Burak; Uğurbaş, Silay Cantürk; Karaca, Çağatay; Keşkek, Nedime Şahinoğlu; Ekinci, Dilbade Yıldız; Balcı, Özlem; Altan, Emir Volkan; Bakbak, Sevda; Ceylan, Nihan Aksu; Kimyon, Sabit; Alyamaç, Günay; Türe, Gamze; Yıldız, Meral; Çalış, Feyza; Sızmaz, Selçuk; Sukgen, Emine; Çetin, Ebru Nevin; Özçimen, Muammer; Demir, Semra Tiryaki; Atila, Huban; Özal, Altan; Tufaner, Gökhan; Yücel, Özlem Eski; Kola, Mehmet; Seven, Erbil; Özdek, Şengül; Durukan, Ali Hakan; Kal, Ali; Çelebi, Ali Riza Cenk; Koytak, İbrahim Arif; Alaçamlı, Göksu; Esme, Arif; Çatak, Onur; Perente, İrfan; Şahin, Alparslan; Akçakaya, Aylin Ardagil; Kıray, Gülünay; Nalçacı, Serhat; Aksoy, Ümit; Bakbak, Ber, School of Medicine, and Department of Internal Medicine

Abstract

Background to evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition. Methods: a prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)=1500 g or gestational age (GA)<= 32 weeks and those with a BW> 1500 g or GA> 32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses. Results: the TR-ROP study included 6115 infants: 4964 (81%) with a GA <= 32 weeks and 1151 (19%) with a GA>32 weeks. Overall, 27% had any stage of ROP and 6.7% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW=1500 g. Of all infants, 414 needed treatment and 395 (95.4%) of the treated infants had a BW <= 1500 g. Sixty-six (16%) of the treated infants did not fulfil the Early Treatment for Retinopathy of Prematurity requirements for treatment. Conclusions: screening of infants with a GA <= 34 weeks or a BW<1700 g appears to be appropriate in Turkey. Monitoring standards of neonatal care and conducting quality improvement projects across the country are recommended to improve neonatal outcomes in Turkish NICUs., NA

Published
2018

29. The protective effects of acetyl L - carnitine which added into Histidine - Tryptophan - Ketoglutarate solution on donor uterus

Author

DEMİRCAN, İlkay, ÖZOĞUL, Candan, AKYOL, Seda Nur, İLHAN, Mustafa Necmi, KAVUTÇU, Mustafa, BARUN, Süreyya, BİLGE, Mustafa, and HİRFANOĞLU, İbrahim Murat

Subjects
acetyl L-carnitine,uterus,transplantation,infertility
Abstract

Objective: At the present times uterus transplantation is an alternative therapy for women with untreatable uterine-based infertility factors. Before transplantation, the donor organ must stored in some solutions, but they may not adequate for protection. In this study, we investigated the potential protective effects of acetyl L-carnitine, added into histidine-tryptophanketoglutarate (HTK) solution, on rat uterus.Methods: We divided 24 female Wistar Albino rats into four groups (n=6). Their uterine tissues were stored into four different solutions at different periods at 4oC ; Group 1 HTK, 4 hours; Group 2. HTK + acetyl L- carnitine, 4 hours, Group 3. HTK, 24 hours; Group 4. HTK + acetyl L- carnitine, 24 hours. Then tissues from uterus were used for histological and biochemical examination.Results: In the study the number of TUNEL positive cells in group 4 was lower than group 3. Biochemically evaluated TBARS and NOS levels were highest in group 3 however CAT level was highest in group 2.Conclusion: In conclusion, addition of acetyl L-carnitine to HTK solution reversed the histological alterations after 24 hours cold storage on rat uterus.

Published
2017

30. Immunohistochemical study of Osteopontin and Bcl-2 gene expression in kidney tissue in histidine-tryptophan-ketoglutarate (HTK) solution prepared with N-acetyl-L-carnitine

Author

EMNİYET, ASİYE ASLI, KAÇAMAK, PINAR, BARUN, SÜREYYA, SARIBAŞ, GÜLİSTAN SANEM, Bilge, Mustafa, HIRFANOĞLU, İBRAHİM MURAT, AKYOL, SEDA NUR, İLHAN, MUSTAFA NECMİ, KAVUTÇU, MUSTAFA, Başer Demircan, İlkay, and ÖZOĞUL, CANDAN

Subjects
Pathology, medicine.medical_specialty, Kidney, biology, Chemistry, HTK solution, Molecular biology, Histidine-tryptophan-ketoglutarate, medicine.anatomical_structure, Gene expression, medicine, biology.protein, Acetyl-L-carnitine, Immunohistochemistry, Osteopontin
Published
2017
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31. Severe IUGR and Long Duration of Antibiotic Treatment may Overcome the Benefits of Appropriate Feeeding Strategies to Prevent Necrotising Enterocolitis

Author

HIRFANOĞLU, İBRAHİM MURAT, TÜRKYILMAZ, CANAN, AKTAS, Selma, Ergenekon, Ebru, KOÇ, ESİN, Onal, Esra, Altuntas, Nilgun, Unal, Sezin, Atalay, Yildiz, Kazanci, Ebru, and Kulali, Ferit

Subjects
General Medicine, digestive system diseases
Abstract

Aim: To compare the characteristic features of premature neonates who developed necrotizing enterocolitis (NEC) or not and review the risks for NEC in our neonatal intensive care unit.

Published
2017

33. Türkiye sarılık veri tabanı ön inceleme raporu

Author

Çalkavur, Şebnem, ATASAY, FATMA BEGÜM, ARSAN, SAADET, GÜLTEKİN, NAZLI, AKIN, YASEMİN, TANRIVERDİ, SEMA, HANTA, DENİZ, KILIÇ, İLKNUR, ULUBAŞ IŞIK, DİLEK, GÖKMEN, ZEYNEL, ALYAMAÇ DİZDAR, EVRİM, BAŞ, AHMET YAĞMUR, NARTER, FATMA, DEMİREL, NİHAL, HIRFANOĞLU, İBRAHİM MURAT, ERDEVE, ÖMER, TUNÇ, GAFFARİ, ALAN, SERDAR, POLAT, ADEM, ÇETİNKAYA, MERİH, BÜYÜKKALE, GÖKHAN, AKDUMAN, HASAN, OKULU, EMEL, TUNÇ, TURAN, and OLUKMAN, ÖZGÜR

Published
2016

34. Nitric Oxide Metabolites and Asymmetric Dimethylarginine Concentrations in Breast Milk

Author

Öztürk, Hakan, primary, Koç, Esin, additional, Özgürtaş, Taner, additional, Yeşildal, Fatih, additional, Kazancı, Ebru, additional, Aksu, Meltem, additional, Özcan, Ebru Kudret, additional, Hirfanoğlu, İbrahim Murat, additional, Önal, Esra, additional, Türkyılmaz, Canan, additional, Ergenekon, Ebru, additional, and Atalay, Yıldız, additional

Published
2017
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38. PREDICTORS FOR EPILEPSY AFTER NEONATAL SEIZURES

Author

GÖKDOĞAN, GÜNTÜLÜ, ÖNAL, ERAY ESRA, ÖZTÜRK, ZEYNEP, HIRFANOĞLU, TUĞBA, SEZİN, ÜNAL, KOÇ, ESİN, ERGENEKON, NURİYE EBRU, ATALAY, YILDIZ, and HIRFANOĞLU, İBRAHİM MURAT

Published
2015

39. Brain death and organ donation of children

Author

KALKAN, GÖKHAN, Ayar, Ganime, Oden Akman, Alkım, Hirfanoğlu, İbrahim Murat, Gündüz, Ramiz Coşkun, Şahin, Sanliay, UYSAL YAZICI, MUTLU, and YAKUT, HALİL İBRAHİM

Abstract

We aimed to define the demographic characteristics, clinical features and outcome of patients with brain death, and to emphasize the importance of organ donation from children. Data for the period from September 2009 to October 2012 were collected retrospectively. Twenty children who were diagnosed as brain death were included. Data including demographics, major cause leading to brain death, duration of brain death evaluation, ancillary tests used to confirm brain death, complications and outcome, duration of hospitalization and organ donation were collected for statistical evaluation. The mean age was 6.2 years, and the male/female ratio 1.85. The major cause leading to brain death was most often traumatic brain injury, seen in 11 patients (55%). The mean duration of brain death evaluation was 6.7 and 1.7 days in Centers I and II respectively. The mean duration of hospitalization was 12.5 days. Electroencephalography (EEG) was used in 18 patients (90%). Complications included hyperglycemia in 13 cases and diabetes incipitus in 7 cases (65% and 35%, respectively). Mean duration of survival was 9.8 days. In Center I, one of the patients' parents gave consent to organ donation, while four parents in Center II agreed to organ donation. The study demonstrated that the duration of brain death evaluation was longer in Center I than in Center II (p0.05). Early diagnosis of brain death and prompt evaluation of patients by ICU physicians once the diagnosis is taken into consideration will probably yield better organs and reduce costs. Training PICU physicians, nurses and organ donation coordinators, and increasing children's awareness of the need for organ donation via means of public communication may increase families' rate of agreement to organ donation in the future.

Published
2014

43. Retrospective analysis on transient tachypnea of the newborn: İs it associated with spinal anesthesia after cesarean section?

Author

GUNAYDIN, Berrin, TAS, Ayca, AKSAKAL, Nur, FAYDACI, Fatma, and HIRFANOĞLU, İbrahim Murat

Subjects
Sezaryen,spinal anestezi,yenidoğan geçici takipnesi (YGT)
Abstract

We investigated whether maternal gestation, newborn gender, delivery times and cord blood gas and pH might play a role in the increased risk of transient tachypnea of the newborn (TTN) after cesarean section (C/S). Data from 114 term parturients scheduled for elective C/S under spinal anesthesia were retrospectively analyzed according to having a newborn with TTN or not. Presence of TTN, neonatal Apgar scores, umbilical artery (UA) and umbilical venous (UV) blood gas analysis and pH, total amount of fluid and ephedrine administered, time intervals related to delivery were documented. TTN was observed in 15 out of 114 cases (13.2%). No significant differences were observed in gestation age, Apgar scores, newborn gender, amount of ephedrine and fluid administered between newborns with or without TTN. Mean UA PO2 tensions of TTNs were significantly lower than in newborns without TTN (p=0.043). Time interval from spinal block to skin incision was significantly longer in newborns with TTN than without TTN (p=0.046). In conclusion, TTN might be associated with spinal anesthesia for C/S. Therefore, reducing the time interval from spinal block to onset of surgery might be one of the important factors to decrease the incidence of TTN after elective C/S under spinal anesthesia., Sezaryenden sonra görülen yenidoğan geçici takipnesi (YGT) riskindeki artışta gebelik haftası, yenidoğan cinsiyeti, doğum süreleri ve kord kan gazı ve pH’nın rolünü gözden geçirdik. Spinal anestezi altında elektif sezaryen uygulanan 114 term gebe, YGT’li yenidoğanı olanlar ya da olmayanlar olarak retrospektif incelendi. YGT bulunması, neonatal Apgar skorları, umbilikal arter (UA) ve umbilikal ven (UV) kan gazı incelemesi ve pH, uygulanan toplam sıvı ve efedrin miktarları, doğum ile ilişkili süreler incelendi. YGT, 114 olgunun 15’inde tespit edildi (%13,2). Gebelik haftası, Apgar skorları, yenidoğan cinsiyeti, efedrin ve sıvı uygulama miktarları bakımından YGT olan ve olmayan yenidoğanlar arasında anlamlı fark yoktu. YGT bulunanlarda ortalama UA PO2 düzeyleri YGT bulunmayanlardan anlamlı derecede düşüktü (p=0.043). Spinal blok ile cilt insizyonu arasındaki süre, YGT bulunanlarda YGT bulunmayanlara göre daha uzundu (p=0.046). Sonuç olarak, YGT sezaryende uygulanan spinal anestezi ile ilişkili olabilir. Bu nedenle, spinal blok ile cerrahiye başlama arasındaki süreyi azaltmak, spinal anestezi altındaki elektif sezaryenlerden sonra görülen YGT insidansını azaltmadaki önemli faktörlerden biri olabilir.

Published
2014

45. Comparing the fatty acid levels of preterm and term breast milk in Turkish women

Author

AYDIN, İbrahim, TURAN, Özden, AYDIN, Fevzi Nuri, KOÇ, Esin, HİRFANOĞLU, İbrahim Murat, AKYOL, Mesut, ÖZTOSUN, Muzaffer, AKGÜL, Emin Özgür, DEMİRİN, Hilmi, KILIÇ, Selim, ERBİL, Mehmet Kemal, and ÖZGÜRTAŞ, Taner

Subjects
medicine.medical_specialty, Breast milk, Population, Breastfeeding, Key words: Breast milk,fatty acid,preterm,term, chemistry.chemical_compound, Lactation, Internal medicine, medicine, education, skin and connective tissue diseases, Cerrahi, chemistry.chemical_classification, education.field_of_study, business.industry, Fatty acid, food and beverages, General Medicine, medicine.anatomical_structure, Endocrinology, chemistry, Myristoleic acid, Term Birth, lipids (amino acids, peptides, and proteins), fatty acid, business, preterm, Breast feeding, term
Abstract

WOS: 000329790100022 PubMed: 25536741 Aim: Lipids are the main source of calories and considered very important in infant growth. We aimed to compare fatty acid composition of term and preterm breast milk. This is the first study that compares the fatty acid levels of preterm and term breast milk in Turkish women. Materials and methods: Breast milk samples were obtained from mothers of term (n = 15) and preterm (n = 15) infants on postnatal days 3, 7, and 28. Fatty acid composition of human breast milk was determined longitudinally by gas-chromatography/mass spectrometry. Results: There were 31 fatty acids measured in the milk samples. In the first month, 17 fatty acid levels had significant differences. In group comparison, some fatty acids (C14:0, C16:0, C18:1 and C20:5) had significantly increased in the preterm group (P = 0.041, P = 0.046, P = 0.027, P = 0.033, respectively), whereas myristoleic acid (C14: 1) and eicosanoic acid (C20: 0) had significantly increased in the term group (P = 0.015, P = 0.048, respectively). Conclusion: Term and preterm milk have different compositions of fatty acids. Breast milk composition changes over time. As a general conclusion, breast milk provides the lipid requirements of infants.

Published
2014

46. USMLE REHBERİ

Author

HIRFANOĞLU, İBRAHİM MURAT and AKSAKAL, MEHMET

Published
2014

49. Familyal glukokortikoid eksikliği olgu sunumu. PS-228

Author

KOÇ, ESİN, ATALAY, YILDIZ, AKTAŞ, SELMA, TÜRKYILMAZ, CANAN, ÖNAL, ERAY ESRA, BİDECİ, AYSUN, ÜNAL, SEZİN, KAZANCI, EBRU, KULALI, FERİT, DÖGER, ESRA, and HIRFANOĞLU, İBRAHİM MURAT

Published
2013

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