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3,290 results on '"Hirata T"'

1. Investigation of chromosome Y loss in men with schizophrenia

Author

Hirata T, Hishimoto A, Otsuka I, Okazaki S, Boku S, Kimura A, Horai T, and Sora I

Subjects
loss of chromosome Y, schizophrenia, disease duration, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Takashi Hirata, Akitoyo Hishimoto, Ikuo Otsuka, Satoshi Okazaki, Shuken Boku, Atsushi Kimura, Tadasu Horai, Ichiro Sora Department of Psychiatry, Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Kobe, Japan Background: Life expectancy is 10–20 years lower in patients with schizophrenia than in the general population. In addition, men with schizophrenia have an earlier age at onset, more pronounced deficit symptoms, poorer course, and poorer response to antipsychotic medications than women. Recent studies have indicated that loss of chromosome Y (LOY) in peripheral blood is associated with an increased risk of all-cause mortality. In order to elucidate the pathophysiology of male-specific features, we investigated the association between LOY and schizophrenia. Materials and methods: The present study included 360 Japanese men (146 patients with schizophrenia vs 214 controls). The relative amount of Y chromosome was defined as the ratio of chromosome Y to chromosome X (Y/X ratio) based on the fluorescent signal of co-amplified short sequences from the Y-X homologous amelogenin genes (AMELY and AMELX). Results: There was no significant difference in the frequency of LOY between the schizophrenia and control groups. However, longer duration of illness was associated with LOY after controlling for age and smoking status in the schizophrenia group (P=0.007, OR =1.11 [95% CI =1.03–1.19]). Conclusion: According to our results, schizophrenia may not have a remarkable effect on blood LOY; however, LOY may be associated with disease course in patients with schizophrenia. Keywords: loss of chromosome Y, schizophrenia, disease duration

Published
2018

2. mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse

Author

Thumkeo, D, Katsura, Y, Nishimura, Y, Kanchanawong, P, Tohyama, K, Ishizaki, T, Kitajima, S, Takahashi, C, Hirata, T, Watanabe, N, Krummel, MF, and Narumiya, S

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Neurosciences, 1.1 Normal biological development and functioning, Underpinning research, Inflammatory and immune system, Actin Cytoskeleton, Actins, Adaptor Proteins, Signal Transducing, Animals, Formins, Gene Expression Regulation, Humans, Immune System, Jurkat Cells, Membrane Proteins, Mice, Mice, Knockout, Phosphorylation, Polymerization, Receptors, Antigen, T-Cell, Signal Transduction, ZAP-70 Protein-Tyrosine Kinase
Abstract

The mechanism by which the cytosolic protein Zap70 physically interacts with and phosphorylates its substrate, the transmembrane protein LAT, upon T cell receptor (TCR) stimulation remains largely obscure. In this study, we found that the pharmacological inhibition of formins, a major class of actin nucleators, suppressed LAT phosphorylation by Zap70, despite TCR stimulation-dependent phosphorylation of Zap70 remaining intact. High-resolution imaging and three-dimensional image reconstruction revealed that localization of phosphorylated Zap70 to the immune synapse (IS) and subsequent LAT phosphorylation are critically dependent on formin-mediated actin polymerization. Using knockout mice, we identify mDia1 and mDia3, which are highly expressed in T cells and which localize to the IS upon TCR activation, as the critical formins mediating this process. Our findings therefore describe previously unsuspected roles for mDia1 and mDia3 in the spatiotemporal control of Zap70-dependent LAT phosphorylation at the IS through regulation of filamentous actin, and underscore their physiological importance in TCR signaling.

Published
2020

9. Wnt7A is a putative prognostic and chemosensitivity marker in human malignant pleural mesothelioma

Author

Jablons, David, Hirata, T, Zheng, Q, Chen, Z, Kinoshita, H, Okamoto, J, Kratz, J, Li, H, Lui, N, Do, H, and Cheng, T

Abstract

Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that has a poor prognosis, limited treatment options, and a worldwide incidence that is expected to increase in the next decade. We evaluated Wnt7A expression in 50 surgically resected tumor

Published
2015

10. A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cancers Harboring HER2 Aberration in Japan (HER2-CS STUDY)

Author

Gemba, K., Ikeda, G., Yasugi, M., Kurimoto, E., Nakano, K., Moritaka, T., Inoue, K., Miyoshi, S., Hamaguchi, N., Ito, R., Sano, Y., Takata, I., Mitani, A., Nishisaka, T., Shoda, H., Nishida, A., Tamamoto, S., Fujitaka, K., Masuda, T., Miyamoto, S., Hattori, N., Sugimoto, K., Fujii, S., Ueda, Y., Sakugawa, M., Fukamatsu, N., Ogata, Y., Bandoh, S., Kanaji, N., Takigawa, N., Yamane, H., Ochi, N., Honda, Y., Oka, M., Kittaka, M., Kubota, T., Yokoyama, A., Yokoyama, T., Sato, E., Shiota, Y., Horita, N., Kanematsu, T., Awaya, Y., Nakamasu, A., Murakami, I., Kuyama, S., Kudo, K., Tamura, T., Umeno, T., Morichika, D., Fujiwara, K., Sato, K., Harada, D., Nogami, N., Nishii, K., Fuchimoto, Y., Kishimoto, T., Kawai, H., Watanabe, K., Tokumo, K., Isobe, T., Tsubata, Y., Inoue, M., Ichikawa, H., Nishioka, Y., Hanibuchi, M., Goto, H., Sumikawa, T., Kodani, M., Suyama, H., Makino, H., Kinosita, N., Shimizu, E., Obata, H., Ikegami, H., Chikamori, K., Maeda, T., Kishino, T., Kamei, H., Ueoka, H., Kunihiro, Y., Kobayashi, T., Ueda, K., Hayashi, M., Kamiya, M., Murakami, J., Sato, A., Ichihara, E., Kubo, T., Ninomiya, T., Hirata, T., Minami, D., Kato, Y., Higo, H., Makimoto, G., Toyota, Y., Oda, N., Nakanishi, M., Kayatani, H., Senoo, S., Kano, H., Watanabe, H., Ando, T., Nakasuka, T., Hara, N., Itano, J., Nakashima, H., Tabata, M., Ninomiya, Kiichiro, Hata, Tae, Yoshioka, Hiroshige, Ohashi, Kadoaki, Bessho, Akihiro, Hosokawa, Shinobu, Ishikawa, Nobuhisa, Yamasaki, Masahiro, Shibayama, Takuo, Aoe, Keisuke, Kozuki, Toshiyuki, Harita, Shingo, Ueda, Yutaka, Murakami, Toshi, Fujimoto, Nobukazu, Yanai, Hiroyuki, Toyooka, Shinichi, Takata, Minoru, Hotta, Katsuyuki, and Kiura, Katsuyuki

Published
2019
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11. Targeting Gli transcription activation by small molecule suppresses tumor growth.

Author

Bosco-Clément, G, Zhang, F, Chen, Z, Zhou, H-M, Li, H, Mikami, I, Hirata, T, Yagui-Beltran, A, Lui, N, Do, H, Cheng, T, Tseng, H-H, Choi, H, Fang, L-T, Kim, I-J, Yue, D, Wang, C, Zheng, Q, Fujii, N, He, B, Jablons, David, and Mann, Michael

Subjects
Animals, Cell Line, Tumor, Cell Proliferation, Female, HCT116 Cells, HEK293 Cells, HT29 Cells, Hedgehog Proteins, Humans, Immunoblotting, Mice, Mice, Nude, NIH 3T3 Cells, Neoplasms, Oligonucleotide Array Sequence Analysis, Protein Binding, Pyrazoles, RNA Interference, Reverse Transcriptase Polymerase Chain Reaction, Small Molecule Libraries, TATA-Binding Protein Associated Factors, Transcription Factor TFIID, Transcription Factors, Transcriptional Activation, Transcriptome, Tumor Burden, Xenograft Model Antitumor Assays, Zinc Finger Protein GLI1
Abstract

Targeted inhibition of Hedgehog signaling at the cell membrane has been associated with anticancer activity in preclinical and early clinical studies. Hedgehog signaling involves activation of Gli transcription factors that can also be induced by alternative pathways. In this study, we identified an interaction between Gli proteins and a transcription coactivator TBP-associated factor 9 (TAF9), and validated its functional relevance in regulating Gli transactivation. We also describe a novel, synthetic small molecule, FN1-8, that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity. More importantly, FN1-8 suppresses cancer cell proliferation in vitro and inhibits tumor growth in vivo. Our results suggest that blocking Gli transactivation, an important control point of multiple oncogenic pathways, may be an effective anticancer strategy.

Published
2014

12. Targeting Gli transcription activation by small molecule suppresses tumor growth

Author

Jablons, David, Bosco-Clément, G, Zhang, F, Chen, Z, Zhou, HM, Li, H, Mikami, I, Hirata, T, Yagui-Beltran, A, Lui, N, and Do, HT

Abstract

Targeted inhibition of Hedgehog signaling at the cell membrane has been associated with anticancer activity in preclinical and early clinical studies. Hedgehog signaling involves activation of Gli transcription factors that can also be induced by alternati

Published
2014

14. Down-Regulation of SIX3 is Associated with Clinical Outcome in Lung Adenocarcinoma

Author

Jablons, David, Mo, ML, Okamoto, J, Chen, Z, Hirata, T, Mikami, I, Bosco-Clément, G, Li, H, Zhou, HM, Jablons, DM, and He, B

Abstract

Background:Lung cancer is a common cancer and the leading cause of cancer-related death worldwide. SIX3 is a human homologue of the highly conserved sine oculis gene family essential during embryonic development in vertebrates, and encodes a homeo-domain c

Published
2013

23. ICES-PICES-PAME Working Group on Integrated Ecosystem Assessment (IEA) for the Central Arctic Ocean (WGICA)

Author

Jorgensen, L.L., Saitoh, Sei-Ichi, Bengtson, J., Bluhm, Bodil A., Christensen, T.R., Edelvang, K., Flores, H., Frie, Anne Kirstine, Fukamachi, Y., Gavrilo, M., Gjøsæter, H., Grebmeier, J., Einar, B., Harada, N., Hedges, K., van den Heuvel-Greve, M.J., Hirata, T., Hirawake, T., Hakon Hoel, A., Ingvaldsen, R., Ivanov, V., Lindal Jørgensen, L., Kuletz, K., Larsen, J.R., Snoejis Leonmalm, P., Melnikov, I., Mosbech, A., Mulder, Ingeborg, Niehoff, Barabara, Nishino, S., Ohnishi, F., Otsuka, N., van Pelt, T., von Quillfeldt, C., Chul Shin, Hyoung, Rune Skjoldal, Hein, Speer, L., and Yang, S.

Subjects
Onderz. Form. D, Life Science
Published
2022

24. Topic: Incisional Hernia — “Difficult case” as specialistic case: real loss of substance, multi recurrences, infections, fistulas, lombocel, burst abdomen, reconstruction of the entire wall

Author

Tuveri, M., Tuveri, A., Nicolo, E., Tsuruma, T., Nagayama, M., Nakano, S., Trombetta, F., Moscato, R., Ghiglione, F., Ciamporcero, T., Galasso, E., Morino, M., Tharao, M., Ndungu, B., Saidi, H., Mwige, P., Gichere, J., Skipworth, J., Younis, I., Floyd, D., Shankar, A., Sarangi, Rathindra, Morehead, P., Williams, J., Minamimura, K., Mafune, K., Irie, S., Kobayashi, T., Hirata, T., Matapurkar, B., Bhargave, A., Lopez-Monclus, J., Garcia-Ureña, M. A., Blazquez-Hernando, L. A., Melero-Montes, D. A., Robin, A., Jimenez-Ceinos, C., Becerra-Ortiz, R., Aguilera, A., Moreno, A., González, E., Light, D., Horgan, L., Lambrecht, J., Skauby, M., Trondsen, E., Vaktskjold, A., Øyen, O., Kulic, V., Matkovic, M., Knaapen, L., Lomme, R., Goor van, H., Iudica, F., Cingolani, P., Isemer, F., Sohlbach, D., Gregorczyk, M., Barski, K., Gogia, B., Alyautdinov, R., Forgione, U., Damiano, G., Palumbo, V. D., Spinelli, G., Ficarella, S., Buscemi, S., Sinagra, E., Marrazzo, A., Lo Monte, A. I., Naranjo-Fernandez, J. R., Soriano, A. Cuado, Orta, E. Martin, Valera-Sanchez, Z., Intantes-Ormad, M., Piñan-Diez, J., Dominguez-Amodeo, A., Ruiz-Zafra, A., Navarrete-Carcer, E., Olivia-Mompean, F., Padillo-Ruiz, J., Cijan, V., Scepanovic, M., Bojovic, P., Bustos-Jimenez, M., Tamayo-López, M. J., MartÜn-Cartes, J. A., Rapoport, A., Waksman, I., Efremov, O., Bukin, A., Biswas, S., Birolini, C., Miranda, J. S., Utiyama, E. M., Rasslan, S., Birolini, D., Bertoglio, C., Magistro, C., De Martini, P., Lo Conte, D., Di Lernia, S., Ferrari, G., Pugliese, R., Bendavid, Y., Dépeault, A., Baik, Y., Oh, Mingu, Park, Youngjin, Choi, Wonyoung, Han, Inwoong, Lee, Changhyung, Chen, F. Q., Shen, Y. M., and Chen, J.

Published
2015
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25. Topic: Rare and Special Cases, The Real “Strange Cases”

Author

Zarrinkhoo, E., Miller, J., Walker, A., Weisman, M., Towfigh, S., Tushev, R., Petkov, I., Tsutsumi, G., Leija, C., Castillo, E., Moncada, F., Mendoza, M., Morua, A. Garcia, Bravo, R., Azcarate, A., Zavala, H., Coman, I. S., Radu, E. V., David, O. I., Stoian, A. R., Strambu, V. E., Iancu, C., Gheorghiu, L. I., Grigorean, V. T., Sinescu, D. R., Plesa, E., Lupascu, C., Straja, D. N., Iacobini, M. A., Ponten, J., Luyer, M., Nienhuijs, S., Permekerlis, A., Petousis, S., Miroforidis, A., Milias, K., Kouridakis, P., Park, J., Kim, D., Nakata, R., Chihara, N., Suzuki, H., Watanabe, M., Uchida, E., Nakanaga, H., Irie, S., Endo, Y., Sonoda, H., Minamimura, K., Kobayashi, T., Hirata, T., Mafune, K., Milosevic, P., Babovic, M., Sorat, D., Light, D., Aawsaj, Y., Horgan, L., Latham, L., Ceriani, I., Livraghi, L., Berselli, M., Gambitta, B., Galvanin, J., Cotronea, C., Pagano, G., Farassino, L., Ambrosoli, A., Crespi, A., Cocozza, E., Kulic, V., Matkovic, M., Percevic, G., Katayama, T., Kumata, Y., Ogawa, E., Horikawa, M., Yaguchi, Y., Inaba, T., Fukushima, R., Jaroszewski, D., Johnson, K., Harold, K., Mori, M., Kumata, M., Guarnieri, F., Smaldone, W., Gaspard, M., Bomben, F., Ceranto, S., Gamarra, M. Florez, Soria, M. Peña, Olivero, C. Fraile, Martinez, M. Josa, Contin, M. Perez, Gómez, J. Cabeza, Jiménez-Valladolid, D., Torres García, A., Descloux, A., Pohle, S., Schramm, B., Schneider, U., Nocito, A., Navarrete, M. Cesardo, Solis, A., Ortega, N., Bergamini, S., Semeraro, C., Armengol, M., Cano, M. Lopez, Torrecilla, N. Ortega, Cavallaro, G., Iorio, O., Avallone, M., Ruscio, S., Rizzello, M., Silecchia, G., Butron, T., Rubio, E., Passas, J., Sopeña, R., Lagaron, E., Silan, F., Garcia, V., Bernal, J., Ortiz, M., Guadarrama, J., Shirai, K., Lomas, M., Shah, B. Bc, and Degloorkar, S. Sarang

Published
2015
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