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1,501 results on '"Hirata, Yoshihiro"'

3. Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target

Author

Arai, Junya, Hayakawa, Yoku, Tateno, Hiroaki, Murakami, Keita, Hayashi, Takeru, Hata, Masahiro, Matsushita, Yuki, Kinoshita, Hiroto, Abe, Sohei, Kurokawa, Ken, Oya, Yukiko, Tsuboi, Mayo, Ihara, Sozaburo, Niikura, Ryota, Suzuki, Nobumi, Iwata, Yusuke, Shiokawa, Toshiro, Shiomi, Chihiro, Uekura, Chie, Yamamoto, Keisuke, Fujiwara, Hiroaki, Kawamura, Satoshi, Nakagawa, Hayato, Mizuno, Seiya, Kudo, Takashi, Takahashi, Satoru, Ushiku, Tetsuo, Hirata, Yoshihiro, Fujii, Chifumi, Nakayama, Jun, Shibata, Shinsuke, Woods, Susan, Worthley, Daniel L., Hatakeyama, Masanori, Wang, Timothy C., and Fujishiro, Mitsuhiro

Published
2024
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5. Non-Helicobacter pylori Gastric Microbiome Modulates Prooncogenic Responses and Is Associated With Gastric Cancer Risk

Author

Niikura, Ryota, Hayakawa, Yoku, Nagata, Naoyoshi, Miyoshi-Akiayama, Tohru, Miyabayashi, Koji, Tsuboi, Mayo, Suzuki, Nobumi, Hata, Masahiro, Arai, Junya, Kurokawa, Ken, Abe, Sohei, Uekura, Chie, Miyoshi, Kotaro, Ihara, Sozaburo, Hirata, Yoshihiro, Yamada, Atsuo, Fujiwara, Hiroaki, Ushiku, Tetsuo, Woods, Susan L., Worthley, Daniel L., Hatakeyama, Masanori, Han, Yiping W., Wang, Timothy C., Kawai, Takashi, and Fujishiro, Mitsuhiro

Published
2023
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7. SAT-176 Itg-Cre/DTA mice develop the autoimmune biliary disease that serologically and pathogenically models human primary biliary cholangitis

Author

Zhang, Jiaqi, primary, Ouchi, Mayu, additional, Nakagawa, Ryo, additional, Kurosugi, Akane, additional, Chihiro, Goto, additional, Kojima, Ryuta, additional, Kaneko, Tatsuya, additional, Ohta, Yuki, additional, Kan, Motoyasu, additional, Nakamura, Masato, additional, Nakamoto, Shingo, additional, Kato, Jun, additional, Hirata, Yoshihiro, additional, and Kato, Naoya, additional

Published
2024
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9. Students’ Attitudes Towards School Subjects

Author

Hirata, Ken, Hirata, Yoshihiro, Lee, Wing On, Series Editor, Lim, Rebekah Wei Ying, Series Editor, Cheah, Horn Mun, Series Editor, Li, Kam Cheong, editor, Tsang, Eva Yuen Mei, editor, and Wong, Billy Tak Ming, editor

Published
2020
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10. Students’ Assessment of a Communication-Oriented E-Learning Platform

Author

Hirata, Yoko, Hirata, Yoshihiro, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Cheung, Simon K. S., editor, Li, Richard, editor, Phusavat, Kongkiti, editor, Paoprasert, Naraphorn, editor, and Kwok, Lam‑For, editor

Published
2020
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12. Applying 'Sketch Engine for Language Learning' in the Japanese English Classroom

Author

Hirata, Yoko and Hirata, Yoshihiro

Abstract

The application of online authentic language data has played an increasingly important role in language teaching. These include freely available online corpora such as the British National Corpus and the Corpus of Contemporary American English. However, students are easily overwhelmed by the enormous amount of incomplete sentences (concordance lines) contained therein and therefore may fail to consult keywords and expressions as a resource tool. As an alternative resource a new web-based platform for English language learning, called Sketch Engine for Language Learning (SkELL), has been developed. Unlike the aforementioned corpora, SkELL generates sufficient amount of complete sentences which help students learn multiple examples of lexical and grammatical items in context. However, little research has been conducted as to how Japanese students with lower English proficiency assess the efficacy of SkELL. This study aims to examine the potential and limitation of SkELL in the language classroom for Japanese students who have almost no online experience in educational settings. The findings indicate that there is a close relationship between students' view of the utilisation and efficacy of the resource and their attitudes toward English education. The study concludes with a discussion of pedagogical implications of the use of SkELL as a valuable educational tool for students who are accustomed to traditional English language learning.

Published
2019
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15. Students’ Evaluation of SkELL: The ‘Sketch Engine for Language Learning’

Author

Hirata, Yoko, Hirata, Yoshihiro, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Cheung, Simon K.S., editor, Kwok, Lam-for, editor, Kubota, Kenichi, editor, Lee, Lap-Kei, editor, and Tokito, Jumpei, editor

Published
2018
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16. BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice

Author

Hayakawa, Yoku, Tsuboi, Mayo, Asfaha, Samuel, Kinoshita, Hiroto, Niikura, Ryota, Konishi, Mitsuru, Hata, Masahiro, Oya, Yukiko, Kim, Woosook, Middelhoff, Moritz, Hikiba, Yohko, Higashijima, Naoko, Ihara, Sozaburo, Ushiku, Tetsuo, Fukayama, Masashi, Tailor, Yagnesh, Hirata, Yoshihiro, Guha, Chandan, Yan, Kelley S., Koike, Kazuhiko, and Wang, Timothy C.

Published
2019
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17. Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis

Author

Kawamura, Satoshi, Matsushita, Yuki, Kurosaki, Shigeyuki, Tange, Mizuki, Fujiwara, Naoto, Hayata, Yuki, Hayakawa, Yoku, Suzuki, Nobumi, Hata, Masahiro, Tsuboi, Mayo, Kishikawa, Takahiro, Kinoshita, Hiroto, Nakatsuka, Takuma, Sato, Masaya, Kudo, Yotaro, Hoshida, Yujin, Umemura, Atsushi, Eguchi, Akiko, Ikenoue, Tsuneo, Hirata, Yoshihiro, Uesugi, Motonari, Tateishi, Ryosuke, Tateishi, Keisuke, Fujishiro, Mitsuhiro, Koike, Kazuhiko, and Nakagawa, Hayato

Subjects
Binding proteins -- Physiological aspects -- Health aspects, Fatty acids -- Synthesis, Fatty liver -- Development and progression -- Care and treatment, Health care industry
Abstract

Enhanced de novo lipogenesis mediated by sterol regulatory element-binding proteins (SREBPs) is thought to be involved in nonalcoholic steatohepatitis (NASH) pathogenesis. In this study, we assessed the impact of SREBP inhibition on NASH and liver cancer development in murine models. Unexpectedly, SREBP inhibition via deletion of the SREBP cleavage-activating protein (SCAP) in the liver exacerbated liver injury, fibrosis, and carcinogenesis despite markedly reduced hepatic steatosis. These phenotypes were ameliorated by restoring SREBP function. Transcriptome and lipidome analyses revealed that SCAP/SREBP pathway inhibition altered the fatty acid (FA) composition of phosphatidylcholines due to both impaired FA synthesis and disorganized FA incorporation into phosphatidylcholine via lysophosphatidylcholine acyltransferase 3 (LPCAT3) downregulation, which led to endoplasmic reticulum (ER) stress and hepatocyte injury. Supplementation with phosphatidylcholines significantly improved liver injury and ER stress induced by SCAP deletion. The activity of the SCAP/ SREBP/LPCAT3 axis was found to be inversely associated with liver fibrosis severity in human NASH. SREBP inhibition also cooperated with impaired autophagy to trigger liver injury. Thus, excessively strong and broad lipogenesis inhibition was counterproductive for NASH therapy; this will have important clinical implications in NASH treatment., Introduction Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD) that is characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis, which lead to progression of [...]

Published
2022
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20. Japanese Students’ Utilization of Courseware in a Blended Learning Environment

Author

Hirata, Yoko, Hirata, Yoshihiro, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cheung, Simon K.S., editor, Kwok, Lam-for, editor, Ma, Will W.K., editor, Lee, Lap-Kei, editor, and Yang, Harrison, editor

Published
2017
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23. New Integrable Family in the n-Dimensional Homogeneous Lotka-Volterra Systems with Abelian Lie Algebra

Author

Imai, Kenji and Hirata, Yoshihiro

Subjects
Nonlinear Sciences - Exactly Solvable and Integrable Systems
Abstract

We present an n-dimensional integrable homogeneous Lotka--Volterra system, which has $(n^2-1)$-dimensional Lie symmetry algebra. Moreover a wider integrable family is derived from the structure of the Lie algebra., Comment: 6 pages, AMS Latex

Published
2002
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24. The Intersection Angles between N-Dimensional Stable and Unstable Manifolds in 2N-Dimensional Symplectic Mappings

Author

Hirata, Yoshihiro, Nozaki, Kazuhiro, and Konishi, Tetsuro

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

We asymptotically compute the intersection angles between N-dimensional stable and unstable manifolds in 2N-dimensional symplectic mappings. There exist particular 1-dimensional stable and unstable sub-manifolds which experience exponentially small splitting of separatrix in our models. We show that the angle between the sub-manifolds is exponentially small with respect to the perturbation parameter $\epsilon$, and the other angles are $O(\epsilon^2)$., Comment: 8 pages, LaTeX

Published
1999
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25. Exponentially small oscillation of 2-dimensional stable and unstable manifolds in 4-dimensional symplectic mappings

Author

Hirata, Yoshihiro, Nozaki, Kazuhiro, and Konishi, Tetsuro

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

Homoclinic bifurcation of 4-dimensional symplectic mappings is asymptotically studied. We construct the 2-dimensional stable and unstable manifolds near the sub-manifolds which experience exponentially small splitting, and successfully obtain exponentially small oscillating terms in the 2-dimensional manifolds., Comment: 6 pages, LaTeX

Published
1999
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31. Asymptotic expansion of 1-dimensional sub-manifolds of stable and unstable manifolds in a 4-dimensional symplectic mapping

Author

Hirata, Yoshihiro and Konishi, Tetsuro

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

We analytically compute asymptotic expansions of a 1-dimensional sub-manifold of stable and unstable manifolds in a 4-dimensional symplectic mapping by using the method called asymptotic expansions beyond all orders. This method enables us to capture exponentially small splitting of separatrices and also to obtain explicit functional approximations of the sub-manifolds. In addition, we show the condition with which homoclinic structure caused by crossing between the stable and unstable sub-manifolds is regarded as a direct product of 2-dimensional mappings., Comment: 20 pages, 8 Encapsulated Postscript figures, LaTeX, corrected some typos, removed some figures

Published
1998

42. Utilization of COCA by Japanese Students

Author

Hirata, Yoko, Hirata, Yoshihiro, Diniz Junqueira Barbosa, Simone, Series editor, Chen, Phoebe, Series editor, Du, Xiaoyong, Series editor, Filipe, Joaquim, Series editor, Kara, Orhun, Series editor, Kotenko, Igor, Series editor, Liu, Ting, Series editor, Sivalingam, Krishna M., Series editor, Washio, Takashi, Series editor, Lam, Jeanne, editor, Ng, Kwan Keung, editor, Cheung, Simon K.S., editor, Wong, Tak Lam, editor, Li, Kam Cheong, editor, and Wang, Fu Lee, editor

Published
2015
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