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367 results on '"Hirashima K"'

1. Dual-tasking over an extended walking distance is associated with falls among community-dwelling older adults

Author

Hirashima K, Higuchi Y, Imaoka M, Todo E, Kitagawa T, and Ueda T

Subjects
cohort study, community-dwelling older adults, dual-task, falls, Geriatrics, RC952-954.6
Abstract

Kenichi Hirashima,1,2 Yumi Higuchi,1 Masakazu Imaoka,1 Emiko Todo,1 Tomomi Kitagawa,1 Tetsuya Ueda11Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University, Habikino Campus, Habikino City, Osaka, Japan; 2Faculty of Health and Welfare, Department of Physical Therapy, Tokushima Bunri University, Nishihamaboji, Yamashiro Town, Tokushima City, Tokushima, Japan Aim: Dual-task methods, in which walking is the primary task, are not sufficient for accurately screening for the risk of falls among healthy older adults. Therefore, the goal of this research was to investigate whether using a dual-task method over an extended walking distance can predict falls among community-dwelling older adults.Methods: We enrolled independent community-dwelling adults aged ≥65 years. Physical performance, cognitive function, psychological function, and a dual-task test were assessed at baseline. Our dual-task test required the subjects to walk 60 m while stepping over lines. The intervals between the lines ranged from 50–100 cm and were unequal. Falls and fall-related injuries were measured over a 12-month follow-up period using monthly postal surveys. Results: Ninety-two of 118 subjects (mean age, 75.4±5.5 years) completed the 12-month follow-up. Sixteen (17.4%) of fallers had injurious falls or fell more than or equal to two times. There were no significant differences between the fallers and non-fallers, except in age and in the number of missteps during the dual-task test when walking ≥40 m. The Kaplan–Meier analysis revealed that those who had more than one misstep while walking ≥40 m had a significantly higher incidence of injurious or multiple falls than those who had no missteps.Conclusion: Our findings suggest that the dual-task method with an extended walking distance may be able to predict falls among community-dwelling older adults. Keywords: cohort study, community-dwelling older adults, dual-task, falls

Published
2015

17. Characterization of a T cell line specific to an anti-Id antibody related to the carbohydrate antigen, sialyl SSEA-1, and the immundominant T cell antigenic site of the antibody

Author

Tsuyuoka, K., Yago, K., Hirashima, K., Ando, S., Hanai, N., Saito, H., Yamasaki, M., Takahashi, K., Fukuda, Y., Nakao, K., and Reiji Kannagi

Subjects
Immunology, Immunology and Allergy
Abstract

The stage-specific embryonic Ag-1 (SSEA-1) is a carbohydrate Ag and regarded as an onco-developmental Ag. Sialyl SSEA-1 Ag, the sialylated form of SSEA-1, is frequently expressed in human cancer cells as well as in murine cancer cells. A mAb, FH-6, was shown to specifically recognize the Ag. We have generated five anti-Id Abs directed to the paratope-related idiotopes of the FH-6 Ab. One of these anti-Id Abs, Id-F2, increased the survival of host mice that were inoculated with Meth-A cells expressing the sialyl SSEA-1 Ag. To clarify the exact mechanism underlying the antitumor effect of the anti-Id Ab, we established a T cell line that recognized Id-F2 in association with MHC class II molecules. The T cell line was CD4+V beta 8+, and produced IL-2, exhibiting helper activity for B cells. The VH CDR2 region of the Id-F2 amino acid sequences turned out to be strongly immunogenic to T cells. When the immune complexes, consisting of the sialyl SSEA-1 Ag, FH-6, and Id-F2, were formed at the Meth-A cell-surface, the T cell line showed a strong proliferative response. The possible roles played by such T cell subsets in the anti-tumor effect are discussed.

Published
1996
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26. A long term follow-up of a randomized trial comparing interferon-α with busulfan for chronic myelogenous leukemia

Author

Ohnishi, K., primary, Tomonaga, M., additional, Kamada, N., additional, Onozawa, K., additional, Kuramoto, A., additional, Dohy, H., additional, Mizoguchi, H., additional, Miyawaki, S., additional, Tsubaki, K., additional, Miura, Y., additional, Omine, M., additional, Kobayashi, T., additional, Naoe, T., additional, Ohshima, T., additional, Hirashima, K., additional, Ohtake, S., additional, Takahashi, I., additional, Morishima, Y., additional, Naito, K., additional, Asou, N., additional, Tanimoto, M., additional, Sakuma, A., additional, and Ohno, R., additional

Published
1998
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37. Sialyl SSEA-1 antigen as a carbohydrate marker of human natural killer cells and immature lymphoid cells

Author

Ohmori, K, Yoneda, T, Ishihara, G, Shigeta, K, Hirashima, K, Kanai, M, Itai, S, Sasaoki, T, Arii, S, and Arita, H

Abstract

The distribution of a carbohydrate antigen, the sialyl SSEA-1 (sialyl Lex-i), in human lymphoid cells was investigated by flow cytometry with a specific monoclonal antibody, MoAb FH-6. We concluded that the lymphocytes positive for the sialyl SSEA-1 antigen present in normal peripheral blood (PB) are natural killer (NK) cells since the positive cells had an NK activity toward K562 cells, and most of the sialyl SSEA- 1+ cells were simultaneously positive for Leu-11 (CD-16) and Leu-19. Essentially, no T and B cells, defined by Leu-4 (CD3) and Leu-16 (CD20), were positive for the sialyl SSEA-1 antigen in PB samples taken from healthy donors and patients with disorders unrelated to lymphoid malignancies. Among the malignant lymphoid cells, many sialylated SSEA- 1+ cells were observed in large granular lymphocyte (LGL) leukemia cells and some acute lymphoblastic leukemia (ALL) blasts, but not in CLL cells or malignant lymphoma cells. Sialyl SSEA-1 was also positive in some cultured human lymphoid cell lines. We conclude that expression of the sialyl SSEA-1 antigen is strictly limited to a distinct population of NK cells among the mature lymphocytes in normal PB, but the antigen is present in a wide range of immature lymphoblasts of T- and B-cell lineages as well as the NK-cell lineage. The sialyl SSEA-1 antigen disappears from the surface of immature lymphocytes of T- and B- cell lineages during the course of maturation.

Published
1989
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38. Effects of aclacinomycin-A on murine leukemia

Author

Nara, N, Miyamoto, T, Hirashima, K, and Momoi, H

Abstract

Effects of aclacinomycin-A (ACM) on leukemic cells and normal hematopoietic stem cells were studied for the purpose of evaluating the usefulness of this agent as an antileukemic agent. ACM suppressed not only leukemic colony-forming unit (LCFU) in the radiation-induced murine erythroleukemia, but also normal hematopoietic stem cells (CFU- S, CFU-C) in mice. However, LCFU was the most sensitive to ACM. After the administration of ACM at a dose of 5 mg/kg. LCFU was suppressed to 0.02 of the control on day 3 and recovered within 5 days. Splenic CFU-S and CFU-C were suppressed to the nadirs on day 2 and day 1, respectively, and they recovered within 5 days. On the basis of the differences in the sensitivities to ACM and recovery patterns between LCFU and normal hematopoietic stem cells. ACM at a single dose of 5 mg/kg was administered every 3 days (total dose of 25 mg/kg) into leukemic mice, and the increase in mean lifespan obtained 113.9%. Effectiveness of ACM in the treatment of acute leukemia was discussed.

Published
1982
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39. A Randomized Trial Comparing Interferon-α With Busulfan for Newly Diagnosed Chronic Myelogenous Leukemia in Chronic Phase

Author

Ohnishi, K., Ohno, R., Tomonaga, M., Kamada, N., Onozawa, K., Kuramoto, A., Dohy, H., Mizoguchi, H., Miyawaki, S., Tsubaki, K., Miura, Y., Omine, M., Kobayashi, T., Naoe, T., Ohshima, T., Hirashima, K., Ohtake, S., Takahashi, I., Morishima, Y., Naito, K., Asou, N., Tanimoto, M., Sakuma, A., and Yamada, K.

Abstract

A multicentor randomized study was conducted to compare the effect of interferon-α (IFN-α) with that of busulfan in newly diagnosed patients with chronic myelogenous leukemia (CML) in chronic phase. From October 1988 to October 1991, 170 patients were randomized to receive either IFN-α or busulfan. Of 159 eligible patients, 31 (38.8%) of 80 patients in the IFN-α group and 43 (54.4%) of 79 patients in the busulfan group achieved complete hematologic remission, and 38.8% in the IFN-α group and 43.0% in the busulfan group achieved partial hematologic remission. A complete cytogenetic response was induced in seven (8.8%) of 80 patients treated with IFN-α and two (2.5%) of 79 patients treated with busulfan, and a partial cytogenetic response was 7.5% (6/80) and 2.5% (2/79), respectively. The difference in major (complete and partial) cytogenetic response between the two groups was significant (P= .046). At a median follow-up of 50 months, the predicted 5-year survival rate was 54% in the IFN-α group and 32% in the busulfan group (P= .0290), and the predicted 5-year rate of remaining in chronic phase was 41% in the IFN-α group and 29% in the busulfan group (P= .1165). As compared with the patients with no cytogenetic response, the patients with any cytogenetic response (complete, partial or minor) after the IFN-α or busulfan treatment were significantly superior in the duration of chronic phase (IFN-α group; P= .0017, busulfan group; P= .0010) even after correction for the time to response using the landmark analysis. However, there was no significant difference in survival rate in the IFN-α group (P= .1065). There was no significant difference in survival rate (P= .3923) and the duration of chronic phase (P= .6258) between the IFN-α and the busulfan group in the patients with a cytogenetic response (complete, partial or minor). These results demonstrate that IFN-α treatment produces a significantly superior cytogenetic response and survival rate as compared with the busulfan treatment, and unexpectedly, that busulfan can also eliminate Philadelphia chromosome positive clone in a few patients who showed prolonged survival rate and duration of chronic phase.

Published
1995
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46. Discussion of “Finch on Public Works”

Author

Finch, J. K., primary, Dent, Elliott J., additional, Allen, C. Frank, additional, Seitz, Bradley G., additional, Stuart, Alfred Allen, additional, Furber, Pierce P., additional, Bessey, R. F., additional, Baker, Donald M., additional, Henry, Philip W., additional, Barrows, H. K., additional, Wiersema, Harry A., additional, Galloway, J. D., additional, Martin, E. S., additional, Hirashima, K. Bert, additional, Ayres, Louis E., additional, Meursinge, John H., additional, Folk, Samuel B., additional, and Mead, Daniel W., additional

Published
1939
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