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Your search keyword '"Hirasaki, Masataka"' showing total 163 results
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163 results on '"Hirasaki, Masataka"'

7. Case report: a rare clinical presentation of a difficult diagnosis of dedifferentiated liposarcoma showing leiomyosarcoma phenotype in the ileocecal region.

Author

Kawasaki, Tomonori, Tashima, Tomoaki, Onohara, Kojiro, Hirano, Yasumitsu, Yamato, Misuzu, Shirotake, Suguru, Torigoe, Tomoaki, Yazawa, Yasuo, Hirasaki, Masataka, Wako, Masanori, Fujimaki, Taro, and Ichikawa, Jiro

Subjects
SARCOMA, FLUORESCENCE in situ hybridization, MAGNETIC resonance imaging, POSITRON emission tomography, GASTROINTESTINAL tumors, LIPOSARCOMA
Abstract

Dedifferentiated liposarcoma is a malignant lipomatous tumor that rarely occurs in the gastrointestinal tract, including the ileocecal region. In this case, computed tomography and magnetic resonance imaging showed no fatty mass located in the mesenteric or submucosal lesion, and positron emission tomography–computed tomography showed a high maximum standardized uptake value, collectively indicating the gastrointestinal stroma tumor and lymphoma. The pathological findings resemble leiomyosarcoma; the immunohistochemistry findings including mouse double minute 2 homolog and cyclin D-dependent kinase-4 and amplification of mouse double minute 2 homolog in fluorescence in situ hybridization just favored the diagnosis of dedifferentiated liposarcoma with leiomyosarcoma phenotype and not leiomyosarcoma. Recently, a new inhibitor for mouse double minute 2 homolog and cyclin D-dependent kinase-4 has been developed, and clinical trials for dedifferentiated liposarcoma are currently ongoing. This could change the treatment strategy drastically compared with other soft tissue sarcomas. Hence, a correct diagnosis of dedifferentiated liposarcoma is required. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Transcriptome Analysis Reveals Enhancement of Cardiogenesis-Related Signaling Pathways by S-Nitroso-N-Pivaloyl-d-Penicillamine: Implications for Improved Diastolic Function and Cardiac Performance

Author

Takenaka, Yasuhiro, Hirasaki, Masataka, Bono, Hidemasa, Nakamura, Shigeo, and Kakinuma, Yoshihiko

Abstract

We previously reported a novel compound called S-nitroso-N-pivaloyl-d-penicillamine (SNPiP), which was screened from a group of nitric oxide donor compounds with a basic chemical structure of S-nitroso-N-acetylpenicillamine, to activate the nonneuronal acetylcholine system. SNPiP-treated mice exhibited improved cardiac output and enhanced diastolic function, without an increase in heart rate. The nonneuronal acetylcholine–activating effects included increased resilience to ischemia, modulation of energy metabolism preference, and activation of angiogenesis. Here, we performed transcriptome analysis of SNPiP-treated mice ventricles to elucidate how SNPiP exerts beneficial effects on cardiac function. A time–course study (24 and 48 hours after SNPiP administration) revealed that SNPiP initially induced Wnt and cyclic guanosine monophosphate–protein kinase G signaling pathways, along with upregulation of genes involved in cardiac muscle tissue development and oxytocin signaling pathway. We also observed enrichment of glycolysis-related genes in response to SNPiP treatment, resulting in a metabolic shift from oxidative phosphorylation to glycolysis, which was suggested by reduced cardiac glucose contents while maintaining adenosine tri-phosphate levels. In addition, SNPiP significantly upregulated atrial natriuretic peptide and sarcolipin, which play crucial roles in calcium handling and cardiac performance. These findings suggest that SNPiP may have therapeutic potential based on the pleiotropic mechanisms elucidated in this study.

Published
2024
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16. PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer: a retrospective study.

Author

Mihara, Yoshiaki, Hirasaki, Masataka, Horita, Yosuke, Fujino, Takashi, Fukushima, Hisayo, Kamakura, Yasuo, Uranishi, Kousuke, Hirano, Yasumitsu, Ryozawa, Shomei, Yasuda, Masanori, Makino, Yoshinori, Shibazaki, Satomi, and Hamaguchi, Tetsuya

Subjects
*ADJUVANT chemotherapy, *CANCER chemotherapy, *COLORECTAL cancer, *GENETIC variation, *ANESTHESIA adjuvants, *CANCER relapse
Abstract

Background: Fluoropyrimidine-based postoperative adjuvant chemotherapy is globally recommended for high-risk stage II and stage III colon cancer. However, adjuvant chemotherapy is often associated with severe adverse events and is not highly effective in preventing recurrence. Therefore, discovery of novel molecular biomarkers of postoperative adjuvant chemotherapy to identify patients at increased risk of recurrent colorectal cancer is warranted. Autophagy (including mitophagy) is activated under chemotherapy-induced stress and contributes to chemotherapy resistance. Expression of autophagy-related genes and their single-nucleotide polymorphisms are reported to be effective predictors of chemotherapy response in some cancers. Our goal was to evaluate the relationship between single-nucleotide variants of autophagy-related genes and recurrence rates in order to identify novel biomarkers that predict the effect of adjuvant chemotherapy in colorectal cancer. Methods: We analyzed surgical or biopsy specimens from 84 patients who underwent radical surgery followed by fluoropyrimidine-based adjuvant chemotherapy at Saitama Medical University International Medical Center between January and December 2016. Using targeted enrichment sequencing, we identified single-nucleotide variants and insertions/deletions in 50 genes, including autophagy-related genes, and examined their association with colorectal cancer recurrence rates. Results: We detected 560 single-nucleotide variants and insertions/deletions in the target region. The results of Fisher's exact test indicated that the recurrence rate of colorectal cancer after adjuvant chemotherapy was significantly lower in patients with the single-nucleotide variants (c.1018G > A [p < 0.005] or c.1562A > C [p < 0.01]) of the mitophagy-related gene PTEN-induced kinase 1. Conclusions: The two single-nucleotide variants of PINK1 gene may be biomarkers of non-recurrence in colorectal cancer patients who received postoperative adjuvant chemotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Correction to: Tumor budding and fibrotic focus—proposed grading system for tumor budding in invasive carcinoma no special type of the breast

Author

Hiratsuka, Miyuki, primary, Hasebe, Takahiro, additional, Ichinose, Yuki, additional, Sakakibara, Ayaka, additional, Fujimoto, Akihiro, additional, Wakui, Noriko, additional, Shibasaki, Satomi, additional, Hirasaki, Masataka, additional, Yasuda, Masanori, additional, Nukui, Akemi, additional, Shimada, Hiroko, additional, Yokogawa, Hideki, additional, Matsuura, Kazuo, additional, Hojo, Takashi, additional, Osaki, Akihiko, additional, and Saeki, Toshiaki, additional

Published
2022
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23. PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer

Author

Mihara, Yoshiaki, primary, Hirasaki, Masataka, additional, Horita, Yosuke, additional, Fujino, Takashi, additional, Fukushima, Hisayo, additional, Kamakura, Yasuo, additional, Uranishi, Kousuke, additional, Hirano, Yasumitsu, additional, Ryozawa, Shomei, additional, Yasuda, Masanori, additional, Makino, Yoshinori, additional, Shibasaki, Satomi, additional, and Hamaguchi, Tetsuya, additional

Published
2022
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26. Vimentin‐positive invasive breast carcinoma of no special type: A breast carcinoma with lethal biological characteristics.

Author

Ichinose, Yuki, Hasebe, Takahiro, Hirasaki, Masataka, Sakakibara, Ayaka, Yokogawa, Hideki, Nukui, Asami, Hiratsuka, Miyuki, Fujimoto, Akihiro, Iso, Chihiro, Wakui, Noriko, Shibasaki, Satomi, Kamada, Koichi, Suzuki, Nobuyuki, Kamakura, Yasuo, Yasuda, Masanori, Aya, Asano, Shimada, Hiroko, Matsuura, Kazuo, Ishiguro, Hiroshi, and Osaki, Akihiko

Subjects
BREAST, RNA sequencing, GENE expression, CELLULAR aging, CARCINOMA, CELL proliferation
Abstract

Vimentin is a stable mesenchymal immunohistochemical marker and is widely recognized as a major marker of mesenchymal tumors. The purpose of the present study was to investigate if the vimentin expression status might serve as a significant predictor of outcomes in patients with invasive breast carcinoma of no special type (IBC‐NST) and to investigate, by comprehensive RNA sequencing analyses, the mechanisms involved in the heightened malignant potential of vimentin‐positive IBC‐NSTs. This study, conducted using the data of 855 patients with IBC‐NST, clearly identified vimentin expression status as a very important independent biological parameter for accurately predicting the outcomes in patients with IBC‐NST. RNA sequence analyses clearly demonstrated significant upregulation of coding RNAs known to be closely associated with cell proliferation or cellular senescence, and significant downregulation of coding RNAs known to be closely associated with transmembrane transport in vimentin‐positive IBC‐NSTs. We conclude that vimentin‐positive IBC‐NSTs show heightened malignant biological characteristics, possibly attributable to the upregulation of RNAs closely associated with proliferative activity and cellular senescence, and downregulation of RNAs closely associated with transmembrane transport in IBC‐NSTs. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Two DNAbinding domains of MGAact in combination to suppress ectopic activation of meiosis‐related genes in mouse embryonic stem cells

Author

Uranishi, Kousuke, Hirasaki, Masataka, Kitamura, Yuka, Mizuno, Yosuke, Nishimoto, Masazumi, Suzuki, Ayumu, and Okuda, Akihiko

Abstract

Although the physiological meaning of the high potential of mouse embryonic stem cells (ESCs) for meiotic entry is not understood, a rigid safeguarding system is required to prevent ectopic onset of meiosis. PRC1.6, a non‐canonical PRC1, is known for its suppression of precocious and ectopic meiotic onset in germ cells and ESCs, respectively. MGA, a scaffolding component of PRC1.6, bears two distinct DNA‐binding domains termed bHLHZ and T‐box. However, it is unclear how this feature contributes to the functions of PRC1.6. Here, we demonstrated that both domains repress distinct sets of genes in murine ESCs, but substantial numbers of meiosis‐related genes are included in both gene sets. In addition, our data demonstrated that bHLHZ is crucially involved in repressing the expression of Meiosin, which plays essential roles in meiotic entry with Stra8, revealing at least part of the molecular mechanisms that link negative and positive regulation of meiotic onset. MGA bearing two distinct DNA‐binding domains is a scaffolding component of PRC1.6 that prevents precocious and ectopic onset of meiosis in germ cells and embryonic stem cells (ESCs), respectively. Here, we demonstrate that both Mga domains repress distinct sets of meiosis‐related genes in ESCs. Our data also identified Meiosinas a linchpin molecule between positive and negative regulations of meiotic onset.

Published
2021
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44. Identification of the Coiled-Coil Domain as an Essential Methyl-CpG-Binding Domain Protein 3 Element for Preserving Lineage Commitment Potential of Embryonic Stem Cells

Author

Hirasaki, Masataka, primary, Ueda, Atsushi, additional, Asaka, Masamitsu N., additional, Uranishi, Kousuke, additional, Suzuki, Ayumu, additional, Kohda, Masakazu, additional, Mizuno, Yosuke, additional, Okazaki, Yasushi, additional, Nishimoto, Masazumi, additional, Sharif, Jafar, additional, Koseki, Haruhiko, additional, and Okuda, Akihiko, additional

Published
2018
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45. Abstract 4411: MiR-130b identified by TCGA miRNA-seq data can predict the radio-sensitivity for patients with HPV-negative oropharyngeal squamous cell carcinoma

Author

Hirasaki Masataka, Akihiro Sakai, Akihiko Okuda, Masashi Sugasawa, Yasunao Kogashiwa, Mitsuhiko Nakahira, and Hitoshi Inoue

Subjects
Cancer Research, Oncology, Mir 130b, HPV Negative, microRNA, Cancer research, Oropharyngeal squamous cell carcinoma, Biology, Radio sensitivity
Abstract

Background: Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) are associated with an increased radio-sensitivity and a favorable outcome compared to HPV-negative OPSCC. To the contrary, HPV-negative patients lack validated prognostic biomarkers. When surgery is selected in the locally advanced HPV-negative OPSCC, the function after surgery may be impaired. Thus, if there is a biomarker to know whether it is radio-sensitive or not, it is useful for treatment selection. It is therefore important to define prognostic biomarkers in this patient population. Method: miRNA sequence (miRNA-seq) and mRNA sequence (mRNA-seq) of the Cancer Genome Atlas (TCGA) data includes 520 HNSCC tumors. Of them, we used gene expression data in HPV-negative OPSCC, which have data on the effects of radiation. We compared the results of miRNA-Seq in two groups of radio-sensitive and radio-resistant, and miRNA whose expression was different between radio-sensitive and radio-resistant HPV-negative OPSCC was selected. To estimate the function of the miRNA, we also performed mRNA-seq analysis. Finally, we validated the miRNA related to the outcome of radiotherapy in our clinical cases. Results: We found that miR-130b is highly expressed in radio-sensitive HPV-negative OPSCC by miRNA-seq. From the mRNA-seq, we identified genes with significantly different expression between radio-resistant and radio-sensitive HPV-negative OPSCC. Clustering analysis and Principal Component Analysis have shown the possibility of discriminating between radio-resistant and radio-sensitive in these gene groups. From the gene ontology (GO) analysis in up regulated genes, we identified GO terms. It is presumed that miR-130b targets several genes related to radio-sensitivity, so it is considered that reduced gene expression in radio-sensitive is related to increased expression of miR130b. Subsequently, we evaluated the expression of miR-130b in our clinical cases. Values of miR130b > 5.372, determined by ROC curves analysis, were associated with significantly longer progression-free survival (p=0.02, log-rank test). Conclusion: The expression change of genes and high expression of miR-130b in radio-sensitive were found by miRNA-seq and mRNA-seq. Our result suggests that miR-130b has a potential to become a biomarker for the radio-sensitivity of HPV-negative OPSCC. The expression of miR-130b as a biomarker for HPV-negative OPSCC requires further evaluation. Citation Format: Hitoshi Inoue, Yasunao Kogashiwa, Hirasaki Masataka, Akihiro Sakai, Mitsuhiko Nakahira, Akihiko Okuda, Masashi Sugasawa. MiR-130b identified by TCGA miRNA-seq data can predict the radio-sensitivity for patients with HPV-negative oropharyngeal squamous cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4411.

Published
2018
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46. Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells

Author

Suzuki, Ayumu, primary, Hirasaki, Masataka, additional, Hishida, Tomoaki, additional, Wu, Jun, additional, Okamura, Daiji, additional, Ueda, Atsushi, additional, Nishimoto, Masazumi, additional, Nakachi, Yutaka, additional, Mizuno, Yosuke, additional, Okazaki, Yasushi, additional, Matsui, Yasuhisa, additional, Belmonte, Juan Carlos Izpisua, additional, and Okuda, Akihiko, additional

Published
2016
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47. Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells

Author

Iseki, Hiroyoshi, primary, Nakachi, Yutaka, additional, Hishida, Tomoaki, additional, Yamashita-Sugahara, Yzumi, additional, Hirasaki, Masataka, additional, Ueda, Atsushi, additional, Tanimoto, Yoko, additional, Iijima, Saori, additional, Sugiyama, Fumihiro, additional, Yagami, Ken-Ichi, additional, Takahashi, Satoru, additional, Okuda, Akihiko, additional, and Okazaki, Yasushi, additional

Published
2015
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49. Functional Compensation Between Myc and PI3K Signaling Supports Self-Renewal of Embryonic Stem Cells

Author

Hishida, Tomoaki, primary, Nakachi, Yutaka, additional, Mizuno, Yosuke, additional, Katano, Miyuki, additional, Okazaki, Yasushi, additional, Ema, Masatsugu, additional, Takahashi, Satoru, additional, Hirasaki, Masataka, additional, Suzuki, Ayumu, additional, Ueda, Atsushi, additional, Nishimoto, Masazumi, additional, Hishida-Nozaki, Yuriko, additional, Vazquez-Ferrer, Eric, additional, Sancho-Martinez, Ignacio, additional, Carlos Izpisua Belmonte, Juan, additional, and Okuda, Akihiko, additional

Published
2015
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