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187 results on '"Hirano, Tomonori"'

1. Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of human pancreatic ductal adenocarcinoma

Author

Tamagawa, Hiroki, Fujii, Masayuki, Togasaki, Kazuhiro, Seino, Takashi, Kawasaki, Shintaro, Takano, Ai, Toshimitsu, Kohta, Takahashi, Sirirat, Ohta, Yuki, Matano, Mami, Kawasaki, Kenta, Machida, Yujiro, Sekine, Shigeki, Machinaga, Akihito, Sasai, Ken, Kodama, Yuzo, Kakiuchi, Nobuyuki, Ogawa, Seishi, Hirano, Tomonori, Seno, Hiroshi, Kitago, Minoru, Kitagawa, Yuko, Iwasaki, Eisuke, Kanai, Takanori, and Sato, Toshiro

Published
2024
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2. Anti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis

Author

Yokode, Masataka, Shiokawa, Masahiro, Kawakami, Hisato, Kuwada, Takeshi, Nishikawa, Yoshihiro, Muramoto, Yuya, Kitamoto, Hiroki, Okabe, Makoto, Yamazaki, Hajime, Okamoto, Norihiro, Morita, Toshihiro, Ohno, Kazuya, Nakanishi, Risa, Takimoto, Ikuhisa, Yasuda, Muneji, Chikugo, Koki, Matsumoto, Shimpei, Yoshida, Hiroyuki, Ota, Sakiko, Nakamura, Takeharu, Okada, Hirokazu, Hirano, Tomonori, Kakiuchi, Nobuyuki, Matsumori, Tomoaki, Yamamoto, Shuji, Uza, Norimitsu, Ooi, Makoto, Kodama, Yuzo, Chiba, Tsutomu, Hayashi, Hidetoshi, and Seno, Hiroshi

Published
2024
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3. Evolutionary histories of breast cancer and related clones

Author

Nishimura, Tomomi, Kakiuchi, Nobuyuki, Yoshida, Kenichi, Sakurai, Takaki, Kataoka, Tatsuki R., Kondoh, Eiji, Chigusa, Yoshitsugu, Kawai, Masahiko, Sawada, Morio, Inoue, Takuya, Takeuchi, Yasuhide, Maeda, Hirona, Baba, Satoko, Shiozawa, Yusuke, Saiki, Ryunosuke, Nakagawa, Masahiro M., Nannya, Yasuhito, Ochi, Yotaro, Hirano, Tomonori, Nakagawa, Tomoe, Inagaki-Kawata, Yukiko, Aoki, Kosuke, Hirata, Masahiro, Nanki, Kosaku, Matano, Mami, Saito, Megumu, Suzuki, Eiji, Takada, Masahiro, Kawashima, Masahiro, Kawaguchi, Kosuke, Chiba, Kenichi, Shiraishi, Yuichi, Takita, Junko, Miyano, Satoru, Mandai, Masaki, Sato, Toshiro, Takeuchi, Kengo, Haga, Hironori, Toi, Masakazu, and Ogawa, Seishi

Published
2023
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4. Anti-integrin αvβ6 autoantibodies in patients with primary sclerosing cholangitis

Author

Yoshida, Hiroyuki, Shiokawa, Masahiro, Kuwada, Takeshi, Muramoto, Yuya, Ota, Sakiko, Nishikawa, Yoshihiro, Maeda, Hirona, Kakiuchi, Nobuyuki, Okamoto, Kanako, Yamazaki, Hajime, Yokode, Masataka, Nakamura, Takeharu, Matsumoto, Shimpei, Hirano, Tomonori, Okada, Hirokazu, Marui, Saiko, Sogabe, Yuko, Matsumori, Tomoaki, Mima, Atsushi, Uza, Norimitsu, Eso, Yuji, Takai, Atsushi, Takahashi, Ken, Ueda, Yoshihide, Kodama, Yuzo, Chiba, Tsutomu, and Seno, Hiroshi

Published
2023
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6. Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations

Author

Nikaido, Mitsuhiro, Kakiuchi, Nobuyuki, Miyamoto, Shin’ichi, Hirano, Tomonori, Takeuchi, Yasuhide, Funakoshi, Taro, Yokoyama, Akira, Ogasawara, Tatsuki, Yamamoto, Yoshihiro, Yamada, Atsushi, Setoyama, Takeshi, Shimizu, Takahiro, Kato, Yukari, Uose, Suguru, Sakurai, Takaki, Minamiguchi, Sachiko, Obama, Kazutaka, Sakai, Yoshiharu, Muto, Manabu, Chiba, Tsutomu, Ogawa, Seishi, and Seno, Hiroshi

Published
2021
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7. Tobacco smoking and somatic mutations in human bronchial epithelium

Author

Yoshida, Kenichi, Gowers, Kate H. C., Lee-Six, Henry, Chandrasekharan, Deepak P., Coorens, Tim, Maughan, Elizabeth F., Beal, Kathryn, Menzies, Andrew, Millar, Fraser R., Anderson, Elizabeth, Clarke, Sarah E., Pennycuick, Adam, Thakrar, Ricky M., Butler, Colin R., Kakiuchi, Noboyuki, and Hirano, Tomonori

Subjects
Tobacco products -- Health aspects, Mutation (Biology) -- Health aspects, Bronchi -- Physiological aspects -- Genetic aspects, Somatic cells -- Physiological aspects -- Genetic aspects, Epithelial cells -- Physiological aspects -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Tobacco smoking causes lung cancer.sup.1-3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA.sup.4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented.sup.6-10, but equivalent data for normal bronchial cells are lacking. Here we sequenced whole genomes of 632 colonies derived from single bronchial epithelial cells across 16 subjects. Tobacco smoking was the major influence on mutational burden, typically adding from 1,000 to 10,000 mutations per cell; massively increasing the variance both within and between subjects; and generating several distinct mutational signatures of substitutions and of insertions and deletions. A population of cells in individuals with a history of smoking had mutational burdens that were equivalent to those expected for people who had never smoked: these cells had less damage from tobacco-specific mutational processes, were fourfold more frequent in ex-smokers than current smokers and had considerably longer telomeres than their more-mutated counterparts. Driver mutations increased in frequency with age, affecting 4-14% of cells in middle-aged subjects who had never smoked. In current smokers, at least 25% of cells carried driver mutations and 0-6% of cells had two or even three drivers. Thus, tobacco smoking increases mutational burden, cell-to-cell heterogeneity and driver mutations, but quitting promotes replenishment of the bronchial epithelium from mitotically quiescent cells that have avoided tobacco mutagenesis. Whole-genome sequencing of normal bronchial epithelium from 16 individuals shows that tobacco smoking increases genomic heterogeneity, mutational burden and driver mutations, whereas stopping smoking promotes replenishment of the epithelium with near-normal cells., Author(s): Kenichi Yoshida [sup.1] , Kate H. C. Gowers [sup.2] , Henry Lee-Six [sup.1] , Deepak P. Chandrasekharan [sup.2] , Tim Coorens [sup.1] , Elizabeth F. Maughan [sup.2] , Kathryn [...]

Published
2020
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8. Development of efficient computational analysis of difference infrared and Raman spectroscopies.

Author

Hirano, Tomonori, Yazawa, Naoya, Wang, Lin, and Morita, Akihiro

Subjects
*RAMAN spectroscopy, *INFRARED spectroscopy, *INFRARED spectra, *SPECTRUM analysis
Abstract

Computational analysis of difference spectra between two analogous systems is a challenging issue, as reliable estimation of a tiny difference spectrum requires an extraordinary precision of the two original spectra. We have developed an alternative new method to calculate the difference spectra under background-free conditions, which greatly improved the efficiency of computation. In this paper, we report further improvement by using efficient parallel implementation and the time correlation formula based on time derivative quantities. As a consequence, the present work achieved further remarkable acceleration in the calculations of difference infrared and Raman spectra in the order of magnitude and thereby allowed us by analyzing these difference spectra at a practical cost of computation. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Age-related remodelling of oesophageal epithelia by mutated cancer drivers

Author

Yokoyama, Akira, Kakiuchi, Nobuyuki, Yoshizato, Tetsuichi, Nannya, Yasuhito, Suzuki, Hiromichi, Takeuchi, Yasuhide, Shiozawa, Yusuke, Sato, Yusuke, Aoki, Kosuke, Kim, Soo Ki, Fujii, Yoichi, Yoshida, Kenichi, Kataoka, Keisuke, Nakagawa, Masahiro M., Inoue, Yoshikage, Hirano, Tomonori, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Sanada, Masashi, Nishikawa, Yoshitaka, Amanuma, Yusuke, Ohashi, Shinya, Aoyama, Ikuo, Horimatsu, Takahiro, Miyamoto, Shin’ichi, Tsunoda, Shigeru, Sakai, Yoshiharu, Narahara, Maiko, Brown, J. B., Sato, Yoshitaka, Sawada, Genta, Mimori, Koshi, Minamiguchi, Sachiko, Haga, Hironori, Seno, Hiroshi, Miyano, Satoru, Makishima, Hideki, Muto, Manabu, and Ogawa, Seishi

Published
2019
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10. Boundary effects and quadrupole contribution in sum frequency generation spectroscopy.

Author

Hirano, Tomonori and Morita, Akihiro

Subjects
*PHOTON upconversion, *QUADRUPOLES, *CENTER of mass, *WATER masses, *STATISTICAL correlation, *NONLINEAR optical spectroscopy
Abstract

Calculation of time correlation functions is a primary task in the computational analysis of sum frequency generation spectroscopy. This paper resolved basic issues to extract interface signals from the calculation. These issues stem from the boundary to restrict the bulk region, which renders the practical computation feasible at a finite and affordable cost. The boundary is found to have significant influences on the time correlation functions, which is closely related to the quadrupole contribution in the nonlinear susceptibility. Thus, we thoroughly examined these influences to establish a proper treatment in performing reliable spectroscopic analysis. We elucidated the distinction of the present boundary effects from the quadrupole contribution and also established a proper center of molecule to minimize the quadrupole effect in the time correlation functions. In the case of liquid water, the proper center was found to be close to the center of mass of a water molecule. [ABSTRACT FROM AUTHOR]

Published
2022
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11. A rare homozygous variant in TERT gene causing variable bone marrow failure, fragility fractures, rib anomalies and extremely short telomere lengths with high serum IgE.

Author

Elbadry, Mahmoud I., Tawfeek, Ahmed, Hirano, Tomonori, El‐Mokhtar, Mohamed A., Kenawey, Mohamed, Helmy, Ahmed M., Ogawa, Seishi, Mughal, M. Zulf, and Nannya, Yasuhito

Subjects
BONE marrow, CYTOTOXIC T cells, TELOMERES, GENETIC variation, BONE density, IMMUNOGLOBULIN E
Abstract

Summary: By whole exome sequencing, we identified a homozygous c.2086 C→T (p.R696C) TERT mutation in patients who present with a spectrum of variable bone marrow failure (BMF), raccoon eyes, dystrophic nails, rib anomalies, fragility fractures (FFs), high IgE level, extremely short telomere lengths (TLs), and skewed numbers of cytotoxic T cells with B and NK cytopenia. Haploinsufficiency in the other family members resulted in short TL and osteopenia. These patients also had the lowest bone mineral density Z‐score compared to other BMF‐patients. Danazol/zoledronic acid improved the outcomes of BMF and FFs. This causative TERT variant has been observed in one family afflicted with dyskeratosis congenita (DC), and thus, we also define a second report and new phenotype related to the variant which should be suspected in severe cases of DC with co‐existent BMF, FFs, high IgE level and rib anomalies. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Comment on "Sum-frequency vibrational spectroscopy of centrosymmetric molecule at interfaces" [J. Chem. Phys. 158, 074701 (2023)].

Author

Hirano, Tomonori, Kumagai, Koichi, Ishiyama, Tatsuya, and Morita, Akihiro

Subjects
*SPECTROMETRY, *MOLECULES, *NONLINEAR optical spectroscopy
Abstract

The article discusses the debate surrounding the mechanism of sum frequency generation (SFG) signals emitted by liquid benzene. The authors argue that the main signal comes from local modes generated by symmetry breaking, while another paper challenges this view and suggests that the dominant mechanism is the interfacial electric quadrupole. The authors refute this argument, stating that their previous paper considered both symmetry breaking and the electric quadrupole in their calculations, while the opposing paper did not properly examine the effect of symmetry breaking. The authors present evidence of symmetry breaking through computational evaluations and the reversal of symmetry breaking at the silica-benzene interface. They recommend that the opposing authors consider these evidences before drawing their conclusion. [Extracted from the article]

Published
2024
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13. Abstract 1511: Origin of synchronous or metachronous multiple pancreatic cancers

Author

Hirano, Tomonori, primary, Kakiuchi, Nobuyuki, additional, Takeuchi, Yasuhide, additional, Nishimura, Tomomi, additional, Masui, Toshihiko, additional, Nagai, Kazuyuki, additional, Anazawa, Takayuki, additional, Minamigushi, Sachiko, additional, Haga, Hironori, additional, Uza, Norimitsu, additional, Seno, Hiroshi, additional, Kodama, Yuzo, additional, Masuda, Atsuhiro, additional, Tanaka, Takeshi, additional, Ogawa, Seishi, additional, Tanaka, Hiroko, additional, and Miyano, Satoru, additional

Published
2023
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14. Abstract 6066: Genomic analysis of end-stage renal disease

Author

Ieiri, Kosuke, primary, Kakiuchi, Nobuyuki, additional, Hirano, Tomonori, additional, Nishimura, Tomomi, additional, Watanabe, Koichi, additional, Tanaka, Hiroko, additional, Miyano, Satoru, additional, Takamatsu, Dai, additional, Monji, Keisuke, additional, Kashiwagi, Eiji, additional, Shiota, Masaki, additional, Inokuchi, Junichi, additional, Eto, Masatoshi, additional, and Ogawa, Seishi, additional

Published
2023
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Author

50737880, 80802785, 90839721, 90836032, 30447958, 80760587, 60594372, 90335266, Yoshida, Hiroyuki, Shiokawa, Masahiro, Kuwada, Takeshi, Muramoto, Yuya, Ota, Sakiko, Nishikawa, Yoshihiro, Maeda, Hirona, Kakiuchi, Nobuyuki, Okamoto, Kanako, Yamazaki, Hajime, Yokode, Masataka, Nakamura, Takeharu, Matsumoto, Shimpei, Hirano, Tomonori, Okada, Hirokazu, Marui, Saiko, Sogabe, Yuko, Matsumori, Tomoaki, Mima, Atsushi, Uza, Norimitsu, Eso, Yuji, Takai, Atsushi, Takahashi, Ken, Ueda, Yoshihide, Kodama, Yuzo, Chiba, Tsutomu, Seno, Hiroshi, 50737880, 80802785, 90839721, 90836032, 30447958, 80760587, 60594372, 90335266, Yoshida, Hiroyuki, Shiokawa, Masahiro, Kuwada, Takeshi, Muramoto, Yuya, Ota, Sakiko, Nishikawa, Yoshihiro, Maeda, Hirona, Kakiuchi, Nobuyuki, Okamoto, Kanako, Yamazaki, Hajime, Yokode, Masataka, Nakamura, Takeharu, Matsumoto, Shimpei, Hirano, Tomonori, Okada, Hirokazu, Marui, Saiko, Sogabe, Yuko, Matsumori, Tomoaki, Mima, Atsushi, Uza, Norimitsu, Eso, Yuji, Takai, Atsushi, Takahashi, Ken, Ueda, Yoshihide, Kodama, Yuzo, Chiba, Tsutomu, and Seno, Hiroshi

Published
2023

16. Evolutionary histories of breast cancer and related clones

Author

90839721, 80779158, 40883707, 80766676, 30516927, 10252462, Nishimura, Tomomi, Kakiuchi, Nobuyuki, Yoshida, Kenichi, Sakurai, Takaki, Kataoka, Tatsuki R., Kondoh, Eiji, Chigusa, Yoshitsugu, Kawai, Masahiko, Sawada, Morio, Inoue, Takuya, Takeuchi, Yasuhide, Maeda, Hirona, Baba, Satoko, Shiozawa, Yusuke, Saiki, Ryunosuke, Nakagawa, Masahiro M., Nannya, Yasuhito, Ochi, Yotaro, Hirano, Tomonori, Nakagawa, Tomoe, Inagaki-Kawata, Yukiko, Aoki, Kosuke, Hirata, Masahiro, Nanki, Kosaku, Matano, Mami, Saito, Megumu, Suzuki, Eiji, Takada, Masahiro, Kawashima, Masahiro, Kawaguchi, Kosuke, Chiba, Kenichi, Shiraishi, Yuichi, Takita, Junko, Miyano, Satoru, Mandai, Masaki, Sato, Toshiro, Takeuchi, Kengo, Haga, Hironori, Toi, Masakazu, Ogawa, Seishi, 90839721, 80779158, 40883707, 80766676, 30516927, 10252462, Nishimura, Tomomi, Kakiuchi, Nobuyuki, Yoshida, Kenichi, Sakurai, Takaki, Kataoka, Tatsuki R., Kondoh, Eiji, Chigusa, Yoshitsugu, Kawai, Masahiko, Sawada, Morio, Inoue, Takuya, Takeuchi, Yasuhide, Maeda, Hirona, Baba, Satoko, Shiozawa, Yusuke, Saiki, Ryunosuke, Nakagawa, Masahiro M., Nannya, Yasuhito, Ochi, Yotaro, Hirano, Tomonori, Nakagawa, Tomoe, Inagaki-Kawata, Yukiko, Aoki, Kosuke, Hirata, Masahiro, Nanki, Kosaku, Matano, Mami, Saito, Megumu, Suzuki, Eiji, Takada, Masahiro, Kawashima, Masahiro, Kawaguchi, Kosuke, Chiba, Kenichi, Shiraishi, Yuichi, Takita, Junko, Miyano, Satoru, Mandai, Masaki, Sato, Toshiro, Takeuchi, Kengo, Haga, Hironori, Toi, Masakazu, and Ogawa, Seishi

Abstract

Recent studies have documented frequent evolution of clones carrying common cancer mutations in apparently normal tissues, which are implicated in cancer development1, 2, 3. However, our knowledge is still missing with regard to what additional driver events take place in what order, before one or more of these clones in normal tissues ultimately evolve to cancer. Here, using phylogenetic analyses of multiple microdissected samples from both cancer and non-cancer lesions, we show unique evolutionary histories of breast cancers harbouring der(1;16), a common driver alteration found in roughly 20% of breast cancers. The approximate timing of early evolutionary events was estimated from the mutation rate measured in normal epithelial cells. In der(1;16)(+) cancers, the derivative chromosome was acquired from early puberty to late adolescence, followed by the emergence of a common ancestor by the patient’s early 30s, from which both cancer and non-cancer clones evolved. Replacing the pre-existing mammary epithelium in the following years, these clones occupied a large area within the premenopausal breast tissues by the time of cancer diagnosis. Evolution of multiple independent cancer founders from the non-cancer ancestors was common, contributing to intratumour heterogeneity. The number of driver events did not correlate with histology, suggesting the role of local microenvironments and/or epigenetic driver events. A similar evolutionary pattern was also observed in another case evolving from an AKT1-mutated founder. Taken together, our findings provide new insight into how breast cancer evolves.

Published
2023

17. Data from Expansion of Gastric Intestinal Metaplasia with Copy Number Aberrations Contributes to Field Cancerization

Author

Kumagai, Ken, primary, Shimizu, Takahiro, primary, Takai, Atsushi, primary, Kakiuchi, Nobuyuki, primary, Takeuchi, Yasuhide, primary, Hirano, Tomonori, primary, Takeda, Haruhiko, primary, Mizuguchi, Aya, primary, Teramura, Mari, primary, Ito, Takahiko, primary, Iguchi, Eriko, primary, Nikaido, Mitsuhiro, primary, Eso, Yuji, primary, Takahashi, Ken, primary, Ueda, Yoshihide, primary, Miyamoto, Shin'ichi, primary, Obama, Kazutaka, primary, Ogawa, Seishi, primary, Marusawa, Hiroyuki, primary, and Seno, Hiroshi, primary

Published
2023
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18. Supplementary Data from Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma

Author

Matsumori, Tomoaki, primary, Kodama, Yuzo, primary, Takai, Atsushi, primary, Shiokawa, Masahiro, primary, Nishikawa, Yoshihiro, primary, Matsumoto, Tomonori, primary, Takeda, Haruhiko, primary, Marui, Saiko, primary, Okada, Hirokazu, primary, Hirano, Tomonori, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Kakiuchi, Nobuyuki, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Morita, Toshihiro, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Yamauchi, Yuki, primary, Kuriyama, Katsutoshi, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Marusawa, Hiroyuki, primary, Kageyama, Ryoichiro, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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19. Table. S4 from Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma

Author

Matsumori, Tomoaki, primary, Kodama, Yuzo, primary, Takai, Atsushi, primary, Shiokawa, Masahiro, primary, Nishikawa, Yoshihiro, primary, Matsumoto, Tomonori, primary, Takeda, Haruhiko, primary, Marui, Saiko, primary, Okada, Hirokazu, primary, Hirano, Tomonori, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Kakiuchi, Nobuyuki, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Morita, Toshihiro, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Yamauchi, Yuki, primary, Kuriyama, Katsutoshi, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Marusawa, Hiroyuki, primary, Kageyama, Ryoichiro, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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20. Supplementary Data from Expansion of Gastric Intestinal Metaplasia with Copy Number Aberrations Contributes to Field Cancerization

Author

Kumagai, Ken, primary, Shimizu, Takahiro, primary, Takai, Atsushi, primary, Kakiuchi, Nobuyuki, primary, Takeuchi, Yasuhide, primary, Hirano, Tomonori, primary, Takeda, Haruhiko, primary, Mizuguchi, Aya, primary, Teramura, Mari, primary, Ito, Takahiko, primary, Iguchi, Eriko, primary, Nikaido, Mitsuhiro, primary, Eso, Yuji, primary, Takahashi, Ken, primary, Ueda, Yoshihide, primary, Miyamoto, Shin'ichi, primary, Obama, Kazutaka, primary, Ogawa, Seishi, primary, Marusawa, Hiroyuki, primary, and Seno, Hiroshi, primary

Published
2023
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21. Data from Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma

Author

Matsumori, Tomoaki, primary, Kodama, Yuzo, primary, Takai, Atsushi, primary, Shiokawa, Masahiro, primary, Nishikawa, Yoshihiro, primary, Matsumoto, Tomonori, primary, Takeda, Haruhiko, primary, Marui, Saiko, primary, Okada, Hirokazu, primary, Hirano, Tomonori, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Kakiuchi, Nobuyuki, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Morita, Toshihiro, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Yamauchi, Yuki, primary, Kuriyama, Katsutoshi, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Marusawa, Hiroyuki, primary, Kageyama, Ryoichiro, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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22. Fig. S4 from Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma

Author

Matsumori, Tomoaki, primary, Kodama, Yuzo, primary, Takai, Atsushi, primary, Shiokawa, Masahiro, primary, Nishikawa, Yoshihiro, primary, Matsumoto, Tomonori, primary, Takeda, Haruhiko, primary, Marui, Saiko, primary, Okada, Hirokazu, primary, Hirano, Tomonori, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Kakiuchi, Nobuyuki, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Morita, Toshihiro, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Yamauchi, Yuki, primary, Kuriyama, Katsutoshi, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Marusawa, Hiroyuki, primary, Kageyama, Ryoichiro, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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23. Supplementary Table from Expansion of Gastric Intestinal Metaplasia with Copy Number Aberrations Contributes to Field Cancerization

Author

Kumagai, Ken, primary, Shimizu, Takahiro, primary, Takai, Atsushi, primary, Kakiuchi, Nobuyuki, primary, Takeuchi, Yasuhide, primary, Hirano, Tomonori, primary, Takeda, Haruhiko, primary, Mizuguchi, Aya, primary, Teramura, Mari, primary, Ito, Takahiko, primary, Iguchi, Eriko, primary, Nikaido, Mitsuhiro, primary, Eso, Yuji, primary, Takahashi, Ken, primary, Ueda, Yoshihide, primary, Miyamoto, Shin'ichi, primary, Obama, Kazutaka, primary, Ogawa, Seishi, primary, Marusawa, Hiroyuki, primary, and Seno, Hiroshi, primary

Published
2023
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24. Abstract P5-13-04: Clonal evolution of mammary epithelial cells into breast cancers

Author

Nishimura, Tomomi, primary, Kakiuchi, Nobuyuki, additional, Yoshida, Kenichi, additional, Sakurai, Takaki, additional, Kataoka, Tatsuki R., additional, Kondoh, Eiji, additional, Chigusa, Yoshitsugu, additional, Kawai, Masahiko, additional, Sawada, Morio, additional, Inoue, Takuya, additional, Takeuchi, Yasuhide, additional, Maeda, Hirona, additional, Baba, Satoko, additional, Shiozawa, Yusuke, additional, Saiki, Ryunosuke, additional, Nakagawa, Masahiro M., additional, Nannya, Yasuhito, additional, Ochi, Yotaro, additional, Hirano, Tomonori, additional, Inagaki-Kawata, Yukiko, additional, Aoki, Kosuke, additional, Hirata, Masahiro, additional, Suzuki, Eiji, additional, Takada, Masahiro, additional, Kawashima, Masahiro, additional, Kawaguchi, Kosuke, additional, Chiba, Kenichi, additional, Shiraishi, Yuichi, additional, Takita, Junko, additional, Miyano, Satoru, additional, Mandai, Masaki, additional, Takeuchi, Kengo, additional, Haga, Hironori, additional, Toi, Masakazu, additional, and Ogawa, Seishi, additional

Published
2023
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25. On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma

Author

Kumagai, Ken, primary, Shimizu, Takahiro, additional, Nikaido, Mitsuhiro, additional, Hirano, Tomonori, additional, Kakiuchi, Nobuyuki, additional, Takeuchi, Yasuhide, additional, Minamiguchi, Sachiko, additional, Sakurai, Takaki, additional, Teramura, Mari, additional, Utsumi, Takahiro, additional, Hiramatsu, Yukiko, additional, Nakanishi, Yuki, additional, Takai, Atsushi, additional, Miyamoto, Shin'ichi, additional, Ogawa, Seishi, additional, and Seno, Hiroshi, additional

Published
2023
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26. Recent progress in simulating microscopic ion transport mechanisms at liquid–liquid interfaces.

Author

Morita, Akihiro, Koizumi, Ai, and Hirano, Tomonori

Subjects
LIQUID-liquid interfaces, FREE surfaces, MOLECULAR dynamics, CHARGE exchange, FREE energy (Thermodynamics)
Abstract

Transport of ions through liquid–liquid interfaces is of fundamental importance to a wide variety of applications. However, since it is quite challenging for experimentalists to directly and selectively observe molecules at the interfaces, microscopic mechanisms of ion transport have been largely presumed from kinetic information. This Perspective illustrates recent examples that molecular dynamics simulations with proper free energy surfaces clarified mechanistic pictures of ion transport. The key is a proper choice of coordinates and defining/calculating free energy surfaces in multidimensional space. Once the free energy surfaces for realistic systems are available, they naturally provide new insight into the ion transport in unprecedented details, including water finger, transient ion pairing, and electron transfer. [ABSTRACT FROM AUTHOR]

Published
2021
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28. The landscape of genetic aberrations in myxofibrosarcoma

Author

90839721, 20515514, 60451811, 40402127, 10252462, Takeuchi, Yasuhide, Yoshida, Kenichi, Halik, Adriane, Kunitz, Annegret, Suzuki, Hiromichi, Kakiuchi, Nobuyuki, Shiozawa, Yusuke, Yokoyama, Akira, Inoue, Yoshikage, Hirano, Tomonori, Yoshizato, Tetsuichi, Aoki, Kosuke, Fujii, Yoichi, Nannya, Yasuhito, Makishima, Hideki, Pfitzner, Berit Maria, Bullinger, Lars, Hirata, Masahiro, Jinnouchi, Keita, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Miyano, Satoru, Okamoto, Takeshi, Haga, Hironori, Ogawa, Seishi, Damm, Frederik, 90839721, 20515514, 60451811, 40402127, 10252462, Takeuchi, Yasuhide, Yoshida, Kenichi, Halik, Adriane, Kunitz, Annegret, Suzuki, Hiromichi, Kakiuchi, Nobuyuki, Shiozawa, Yusuke, Yokoyama, Akira, Inoue, Yoshikage, Hirano, Tomonori, Yoshizato, Tetsuichi, Aoki, Kosuke, Fujii, Yoichi, Nannya, Yasuhito, Makishima, Hideki, Pfitzner, Berit Maria, Bullinger, Lars, Hirata, Masahiro, Jinnouchi, Keita, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Miyano, Satoru, Okamoto, Takeshi, Haga, Hironori, Ogawa, Seishi, and Damm, Frederik

Abstract

Myxofibrosarcoma (MFS) is a rare subtype of sarcoma, whose genetic basis is poorly understood. We analyzed 69 MFS cases using whole-genome (WGS), whole-exome (WES) and/or targeted-sequencing (TS). Newly sequenced genomic data were combined with additional deposited 116 MFS samples. WGS identified a high number of structural variations (SVs) per tumor most frequently affecting the TP53 and RB1 loci, 40% of tumors showed a BRCAness-associated mutation signature, and evidence of chromothripsis was found in all cases. Most frequently mutated/copy number altered genes affected known disease drivers such as TP53 (56.2%), CDKN2A/B (29.7%), RB1 (27.0%), ATRX (19.5%) and HDLBP (18.9%). Several previously unappreciated genetic aberrations including MUC17, FLG and ZNF780A were identified in more than 20% of patients. Longitudinal analysis of paired diagnosis and relapse time points revealed a 1.2-fold mutation number increase accompanied with substantial changes in clonal composition over time. Our study highlights the genetic complexity underlying sarcomagenesis of MFS.

Published
2022

29. Abstract 6198: Genetic analysis of synchronous or metachronous multiple pancreatic cancers

Author

Hirano, Tomonori, primary, Kakiuchi, Nobuyuki, additional, Yasuhide, Takeuchi, additional, Nishimura, Tomomi, additional, Masui, Toshihiko, additional, Nagai, Kazuyuki, additional, Anazawa, Takayuki, additional, Minamiguchi, Sachiko, additional, Haga, Hironori, additional, Uza, Norimitsu, additional, Seno, Hiroshi, additional, Kodama, Yuzo, additional, Masuda, Atsuhiro, additional, Tanaka, Takeshi, additional, Shiraishi, Yuichi, additional, Miyano, Satoru, additional, and Ogawa, Seishi, additional

Published
2022
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30. Abstract 6085: Clonal evolution of mammary epithelial cells into breast cancers

Author

Nishimura, Tomomi, primary, Kakiuchi, Nobuyuki, additional, Yoshida, Kenichi, additional, Takeuchi, Yasuhide, additional, Maeda, Hirona, additional, Shiozawa, Yusuke, additional, Nakagawa, Masahiro M., additional, Saiki, Ryunosuke, additional, Ochi, Yotaro, additional, Hirano, Tomonori, additional, Kawata, Yukiko, additional, Aoki, Kosuke, additional, Hirata, Masahiro, additional, Kataoka, Tatsuki R., additional, Sakurai, Takaki, additional, Baba, Satoko, additional, Shiraishi, Yuichi, additional, Chiba, Kenichi, additional, Takeuchi, Kengo, additional, Haga, Hironori, additional, Miyano, Satoru, additional, Toi, Masakazu, additional, and Ogawa, Seishi, additional

Published
2022
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31. The landscape of genetic aberrations in myxofibrosarcoma

Author

Takeuchi, Yasuhide, primary, Yoshida, Kenichi, additional, Halik, Adriane, additional, Kunitz, Annegret, additional, Suzuki, Hiromichi, additional, Kakiuchi, Nobuyuki, additional, Shiozawa, Yusuke, additional, Yokoyama, Akira, additional, Inoue, Yoshikage, additional, Hirano, Tomonori, additional, Yoshizato, Tetsuichi, additional, Aoki, Kosuke, additional, Fujii, Yoichi, additional, Nannya, Yasuhito, additional, Makishima, Hideki, additional, Pfitzner, Berit Maria, additional, Bullinger, Lars, additional, Hirata, Masahiro, additional, Jinnouchi, Keita, additional, Shiraishi, Yuichi, additional, Chiba, Kenichi, additional, Tanaka, Hiroko, additional, Miyano, Satoru, additional, Okamoto, Takeshi, additional, Haga, Hironori, additional, Ogawa, Seishi, additional, and Damm, Frederik, additional

Published
2022
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32. Expansion of Gastric Intestinal Metaplasia with Copy Number Aberrations Contributes to Field Cancerization

Author

Kumagai, Ken, primary, Shimizu, Takahiro, additional, Takai, Atsushi, additional, Kakiuchi, Nobuyuki, additional, Takeuchi, Yasuhide, additional, Hirano, Tomonori, additional, Takeda, Haruhiko, additional, Mizuguchi, Aya, additional, Teramura, Mari, additional, Ito, Takahiko, additional, Iguchi, Eriko, additional, Nikaido, Mitsuhiro, additional, Eso, Yuji, additional, Takahashi, Ken, additional, Ueda, Yoshihide, additional, Miyamoto, Shin'ichi, additional, Obama, Kazutaka, additional, Ogawa, Seishi, additional, Marusawa, Hiroyuki, additional, and Seno, Hiroshi, additional

Published
2022
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33. Abstract 2185: Genetic analysis of metachronous pancreatic cancers

Author

Hirano, Tomonori, primary, Kakiuchi, Nobuyuki, additional, Takeuchi, Yasuhide, additional, Nishimura, Tomomi, additional, Masui, Toshihiko, additional, Minamiguhi, Sachiko, additional, Haga, Hironori, additional, Chiba, Kenichi, additional, Tanaka, Hiroko, additional, Shiraishi, Yuichi, additional, Miyano, Satoru, additional, Norimitsu, Uza, additional, Kodama, Yuzo, additional, Seno, Hiroshi, additional, and Ogawa, Seishi, additional

Published
2021
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34. Abstract 2675: Clonal expansion of skin keratinocyte

Author

Ishida, Yoshihiro, primary, Kakiuchi, Nobuyuki, additional, Fujii, Yoichi, additional, Hirano, Tomonori, additional, Inoue, Yoshikage, additional, Nishimura, Tomomi, additional, Ogasawara, Tatsuki, additional, Maeda, Hirona, additional, Shiraishi, Yuichi, additional, Chiba, Kenichi, additional, Tanaka, Hiroko, additional, Miyano, Satoru, additional, Otsuka, Atsushi, additional, Kabashima, Kenji, additional, and Ogawa, Seishi, additional

Published
2021
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35. This title is unavailable for guests, please login to see more information.

Author

50737880, 90839721, 60451811, 90836032, 00789638, 80802785, 30447958, 90335266, Kuwada, Takeshi, Shiokawa, Masahiro, Kodama, Yuzo, Ota, Sakiko, Kakiuchi, Nobuyuki, Nannya, Yasuhito, Yamazaki, Hajime, Yoshida, Hiroyuki, Nakamura, Takeharu, Matsumoto, Shimpei, Muramoto, Yuya, Yamamoto, Shuji, Honzawa, Yusuke, Kuriyama, Katsutoshi, Okamoto, Kanako, Hirano, Tomonori, Okada, Hirokazu, Marui, Saiko, Sogabe, Yuko, Morita, Toshihiro, Matsumori, Tomoaki, Mima, Atsushi, Nishikawa, Yoshihiro, Ueda, Tatsuki, Matsumura, Kazuyoshi, Uza, Norimitsu, Chiba, Tsutomu, Seno, Hiroshi, 50737880, 90839721, 60451811, 90836032, 00789638, 80802785, 30447958, 90335266, Kuwada, Takeshi, Shiokawa, Masahiro, Kodama, Yuzo, Ota, Sakiko, Kakiuchi, Nobuyuki, Nannya, Yasuhito, Yamazaki, Hajime, Yoshida, Hiroyuki, Nakamura, Takeharu, Matsumoto, Shimpei, Muramoto, Yuya, Yamamoto, Shuji, Honzawa, Yusuke, Kuriyama, Katsutoshi, Okamoto, Kanako, Hirano, Tomonori, Okada, Hirokazu, Marui, Saiko, Sogabe, Yuko, Morita, Toshihiro, Matsumori, Tomoaki, Mima, Atsushi, Nishikawa, Yoshihiro, Ueda, Tatsuki, Matsumura, Kazuyoshi, Uza, Norimitsu, Chiba, Tsutomu, and Seno, Hiroshi

Published
2021

36. Identification of an Anti–Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis

Author

Kuwada, Takeshi, primary, Shiokawa, Masahiro, additional, Kodama, Yuzo, additional, Ota, Sakiko, additional, Kakiuchi, Nobuyuki, additional, Nannya, Yasuhito, additional, Yamazaki, Hajime, additional, Yoshida, Hiroyuki, additional, Nakamura, Takeharu, additional, Matsumoto, Shimpei, additional, Muramoto, Yuya, additional, Yamamoto, Shuji, additional, Honzawa, Yusuke, additional, Kuriyama, Katsutoshi, additional, Okamoto, Kanako, additional, Hirano, Tomonori, additional, Okada, Hirokazu, additional, Marui, Saiko, additional, Sogabe, Yuko, additional, Morita, Toshihiro, additional, Matsumori, Tomoaki, additional, Mima, Atsushi, additional, Nishikawa, Yoshihiro, additional, Ueda, Tatsuki, additional, Matsumura, Kazuyoshi, additional, Uza, Norimitsu, additional, Chiba, Tsutomu, additional, and Seno, Hiroshi, additional

Published
2021
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37. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

Author

90839721, 90322651, 20515514, 00789638, 40511829, 80646373, 40883707, 20772403, 70335454, 40402127, 10252462, 10379092, 90335266, Kakiuchi, Nobuyuki, Yoshida, Kenichi, Uchino, Motoi, Kihara, Takako, Akaki, Kotaro, Inoue, Yoshikage, Kawada, Kenji, Nagayama, Satoshi, Yokoyama, Akira, Yamamoto, Shuji, Matsuura, Minoru, Horimatsu, Takahiro, Hirano, Tomonori, Goto, Norihiro, Takeuchi, Yasuhide, Ochi, Yotaro, Shiozawa, Yusuke, Kogure, Yasunori, Watatani, Yosaku, Fujii, Yoichi, Kim, Soo Ki, Kon, Ayana, Kataoka, Keisuke, Yoshizato, Tetsuichi, Nakagawa, Masahiro M., Yoda, Akinori, Nanya, Yasuhito, Makishima, Hideki, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Sanada, Masashi, Sugihara, Eiji, Sato, Taka-aki, Maruyama, Takashi, Miyoshi, Hiroyuki, Taketo, Makoto Mark, Oishi, Jun, Inagaki, Ryosaku, Ueda, Yutaka, Okamoto, Shinya, Okajima, Hideaki, Sakai, Yoshiharu, Sakurai, Takaki, Haga, Hironori, Hirota, Seiichi, Ikeuchi, Hiroki, Nakase, Hiroshi, Marusawa, Hiroyuki, Chiba, Tsutomu, Takeuchi, Osamu, Miyano, Satoru, Seno, Hiroshi, Ogawa, Seishi, 90839721, 90322651, 20515514, 00789638, 40511829, 80646373, 40883707, 20772403, 70335454, 40402127, 10252462, 10379092, 90335266, Kakiuchi, Nobuyuki, Yoshida, Kenichi, Uchino, Motoi, Kihara, Takako, Akaki, Kotaro, Inoue, Yoshikage, Kawada, Kenji, Nagayama, Satoshi, Yokoyama, Akira, Yamamoto, Shuji, Matsuura, Minoru, Horimatsu, Takahiro, Hirano, Tomonori, Goto, Norihiro, Takeuchi, Yasuhide, Ochi, Yotaro, Shiozawa, Yusuke, Kogure, Yasunori, Watatani, Yosaku, Fujii, Yoichi, Kim, Soo Ki, Kon, Ayana, Kataoka, Keisuke, Yoshizato, Tetsuichi, Nakagawa, Masahiro M., Yoda, Akinori, Nanya, Yasuhito, Makishima, Hideki, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Sanada, Masashi, Sugihara, Eiji, Sato, Taka-aki, Maruyama, Takashi, Miyoshi, Hiroyuki, Taketo, Makoto Mark, Oishi, Jun, Inagaki, Ryosaku, Ueda, Yutaka, Okamoto, Shinya, Okajima, Hideaki, Sakai, Yoshiharu, Sakurai, Takaki, Haga, Hironori, Hirota, Seiichi, Ikeuchi, Hiroki, Nakase, Hiroshi, Marusawa, Hiroyuki, Chiba, Tsutomu, Takeuchi, Osamu, Miyano, Satoru, Seno, Hiroshi, and Ogawa, Seishi

Abstract

Chronic inflammation is accompanied by recurring cycles of tissue destruction and repair and is associated with an increased risk of cancer1, 2, 3. However, how such cycles affect the clonal composition of tissues, particularly in terms of cancer development, remains unknown. Here we show that in patients with ulcerative colitis, the inflamed intestine undergoes widespread remodelling by pervasive clones, many of which are positively selected by acquiring mutations that commonly involve the NFKBIZ, TRAF3IP2, ZC3H12A, PIGR and HNRNPF genes and are implicated in the downregulation of IL-17 and other pro-inflammatory signals. Mutational profiles vary substantially between colitis-associated cancer and non-dysplastic tissues in ulcerative colitis, which indicates that there are distinct mechanisms of positive selection in both tissues. In particular, mutations in NFKBIZ are highly prevalent in the epithelium of patients with ulcerative colitis but rarely found in both sporadic and colitis-associated cancer, indicating that NFKBIZ-mutant cells are selected against during colorectal carcinogenesis. In further support of this negative selection, we found that tumour formation was significantly attenuated in Nfkbiz-mutant mice and cell competition was compromised by disruption of NFKBIZ in human colorectal cancer cells. Our results highlight common and discrete mechanisms of clonal selection in inflammatory tissues, which reveal unexpected cancer vulnerabilities that could potentially be exploited for therapeutics in colorectal cancer.

Published
2020

38. Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma

Author

Matsumori, Tomoaki, primary, Kodama, Yuzo, additional, Takai, Atsushi, additional, Shiokawa, Masahiro, additional, Nishikawa, Yoshihiro, additional, Matsumoto, Tomonori, additional, Takeda, Haruhiko, additional, Marui, Saiko, additional, Okada, Hirokazu, additional, Hirano, Tomonori, additional, Kuwada, Takeshi, additional, Sogabe, Yuko, additional, Kakiuchi, Nobuyuki, additional, Tomono, Teruko, additional, Mima, Atsushi, additional, Morita, Toshihiro, additional, Ueda, Tatsuki, additional, Tsuda, Motoyuki, additional, Yamauchi, Yuki, additional, Kuriyama, Katsutoshi, additional, Sakuma, Yojiro, additional, Ota, Yuji, additional, Maruno, Takahisa, additional, Uza, Norimitsu, additional, Marusawa, Hiroyuki, additional, Kageyama, Ryoichiro, additional, Chiba, Tsutomu, additional, and Seno, Hiroshi, additional

Published
2020
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40. A novel technique for mapping biopsy of bile duct cancer

Author

Okada, Hirokazu, additional, Uza, Norimitsu, additional, Matsumori, Tomoaki, additional, Matsumoto, Shimpei, additional, Muramoto, Yuya, additional, Ota, Sakiko, additional, Nakamura, Takeharu, additional, Yoshida, Hiroyuki, additional, Hirano, Tomonori, additional, Kuwada, Takeshi, additional, Marui, Saiko, additional, Sogabe, Yuko, additional, Morita, Toshihiro, additional, Kakiuchi, Nobuyuki, additional, Mima, Atsushi, additional, Ueda, Tatsuki, additional, Nishikawa, Yoshihiro, additional, Tsuda, Motoyuki, additional, Maruno, Takahisa, additional, Shiokawa, Masahiro, additional, Takahashi, Ken, additional, Taura, Kojiro, additional, Minamiguchi, Sachiko, additional, Kodama, Yuzo, additional, and Seno, Hiroshi, additional

Published
2020
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41. Abstract 5875: Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals frequent mutations affecting IL-17 signaling pathway and novel cancer vulnerability

Author

Kakiuchi, Nobuyuki, primary, Yoshida, Kenichi, additional, Uchino, Motoi, additional, Kihara, Takako, additional, Kotaro, Akaki, additional, Inoue, Yoshikage, additional, Kawada, Kenji, additional, Nagayama, Satoshi, additional, Yokoyama, Akira, additional, Hirano, Tomonori, additional, Takeuchi, Yasuhide, additional, Miyoshi, Hiroyuki, additional, Sakai, Yoshiharu, additional, Haga, Hironori, additional, Hirota, Seiichi, additional, Ikeuchi, Hiroki, additional, Takeuchi, Osamu, additional, Miyano, Satoru, additional, Seno, Hiroshi, additional, and Ogawa, Seishi, additional

Published
2020
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42. Abstract 2342: Tobacco exposure and somatic mutations in normal bronchial epithelia

Author

Yoshida, Kenichi, primary, Gowers, Kate HC, additional, Lee-Six, Henry, additional, Chandrasekharan, Deepak P., additional, Coorens, Tim, additional, Maughan, Elizabeth F., additional, Beal, Kathryn, additional, Menzies, Andrew, additional, Millar, Fraser R., additional, Anderson, Elizabeth, additional, Clarke, Sarah E., additional, Pennycuick, Adam, additional, Thackeray, Ricky M., additional, Butler, Colin R., additional, Kakiuchi, Nobuyuki, additional, Hirano, Tomonori, additional, Hynds, Robert E., additional, Stratton, Michael R., additional, Martincorena, Inigo, additional, Janes, Sam M., additional, and Campbell, Peter J., additional

Published
2020
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43. Utility of laser-cut covered self-expandable metal stents for unresectable malignant distal biliary obstruction: a single-center experience

Author

Marui, Saiko, additional, Uza, Norimitsu, additional, Yamazaki, Hajime, additional, Ota, Sakiko, additional, Nakamura, Takeharu, additional, Yoshida, Hiroyuki, additional, Okada, Hirokazu, additional, Hirano, Tomonori, additional, Kuwada, Takeshi, additional, Sogabe, Yuko, additional, Tomono, Teruko, additional, Matsumori, Tomoaki, additional, Morita, Toshihiro, additional, Nishikawa, Yoshihiro, additional, Tsuda, Motoyuki, additional, Maruno, Takahisa, additional, Shiokawa, Masahiro, additional, Kodama, Yuzo, additional, and Seno, Hiroshi, additional

Published
2020
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46. Abstract 5877: Genetic analysis of metachronous pancreatic cancers

Author

Seishi Ogawa, Yoichi Fujii, Satoru Miyano, Kenichi Chiba, Hiroko Tanaka, Nobuyuki Kakiuchi, Hiroshi Seno, Hirano Tomonori, Sachiko Minamiguchi, Yasuhide Takeuchi, Hironori Haga, Yoshikage Inoue, Toshihiko Masui, Hideki Makishima, Akira Yokoyama, Norimitsu Uza, Yuzo Kodama, Yuichi Shiraishi, Shinji Uemoto, and Tomomi Nishimura

Subjects
Cancer Research, Oncology, Cancer research, Biology, Genetic analysis
Abstract

[Introduction] Early detection of pancreatic cancer is a key to curable surgery. However, many patients are diagnosed in an advanced stage and even in those cases who had a surgical resection of early stage tumors, metachronous pancreatic cancer in residual pancreas prevents cure. Thus, it is important to control metachronous tumors to improve clinical outcomes, whose pathogenesis is poorly understood. In this study, we aimed to reveal the origin of metachronous pancreatic cancers using an unbiased detection of somatic mutations in primary and metachronous cancers as well as adjacent precursor lesions. [Methods] Serially obtained formalin-fixed paraffin-embedded surgical specimens from 8 patient who had undergone curative surgery for an early stage pancreatic cancer were subjected to laser microdissection for the enrichment of tumor and PanIN lesions, from which DNA was extracted and analyzed for somatic mutations of each lesion by whole-exome sequencing (WES) with matched normal DNA. Based on shared and private mutations across different samples, we interrogated history of clonal evolution of these lesions. [Results] Pathology for primary cancer were margin-negative in all patients. The median interval between the initial and second surgery was 29.8 months (23 - 64.4 months). We analyzed a median of two cancer and one PanIN samples (0-5), from which we identified a median number of 45(range: 26-69) and 20 (14-42) somatic mutations using WES, respectively. None of the patients have known pathogenic germline variants. All samples had one or more driver mutations. In each patient, all driver mutations and more than half of passenger mutations were shared between primary and metachronous cancer samples, suggesting that those metachronous tumors are evolutionally closely related to the primary cancer. Negative pathology of the margins at the initial surgery suggested that those metachronous lesions originated from distant dissemination or metastasis, rather than contiguous, intraductal invasion. By contrast, none of the mutations other than hotspot KRAS mutations were shared between precursor lesions and cancer samples. Despite multiple independent clones in the precancerous lesion, all metachronous tumors originated from the primary lesions in this study. [Conclusions] Our study suggests that even early pancreatic cancer might be disseminated within the pancreas and contribute to metachronous cancers, suggesting the importance of close monitoring of the recurrence in the residual pancreas. Citation Format: Hirano Tomonori, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Yoshikage Inoue, Tomomi Nishimura, Yoichi Fujii, Akira Yokoyama, Hideki Makishima, Toshihiko Masui, Shinji Uemoto, Sachiko Minamiguchi, Hironori Haga, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Satoru Miyano, Norimitsu Uza, Yuzo Kodama, Hiroshi Seno, Seishi Ogawa. Genetic analysis of metachronous pancreatic cancers [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5877.

Published
2020
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47. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

Author

Kakiuchi, Nobuyuki, primary, Yoshida, Kenichi, additional, Uchino, Motoi, additional, Kihara, Takako, additional, Akaki, Kotaro, additional, Inoue, Yoshikage, additional, Kawada, Kenji, additional, Nagayama, Satoshi, additional, Yokoyama, Akira, additional, Yamamoto, Shuji, additional, Matsuura, Minoru, additional, Horimatsu, Takahiro, additional, Hirano, Tomonori, additional, Goto, Norihiro, additional, Takeuchi, Yasuhide, additional, Ochi, Yotaro, additional, Shiozawa, Yusuke, additional, Kogure, Yasunori, additional, Watatani, Yosaku, additional, Fujii, Yoichi, additional, Kim, Soo Ki, additional, Kon, Ayana, additional, Kataoka, Keisuke, additional, Yoshizato, Tetsuichi, additional, Nakagawa, Masahiro M., additional, Yoda, Akinori, additional, Nanya, Yasuhito, additional, Makishima, Hideki, additional, Shiraishi, Yuichi, additional, Chiba, Kenichi, additional, Tanaka, Hiroko, additional, Sanada, Masashi, additional, Sugihara, Eiji, additional, Sato, Taka-aki, additional, Maruyama, Takashi, additional, Miyoshi, Hiroyuki, additional, Taketo, Makoto Mark, additional, Oishi, Jun, additional, Inagaki, Ryosaku, additional, Ueda, Yutaka, additional, Okamoto, Shinya, additional, Okajima, Hideaki, additional, Sakai, Yoshiharu, additional, Sakurai, Takaki, additional, Haga, Hironori, additional, Hirota, Seiichi, additional, Ikeuchi, Hiroki, additional, Nakase, Hiroshi, additional, Marusawa, Hiroyuki, additional, Chiba, Tsutomu, additional, Takeuchi, Osamu, additional, Miyano, Satoru, additional, Seno, Hiroshi, additional, and Ogawa, Seishi, additional

Published
2019
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48. Abstract 3429: Genetic analysis of pancreatic neuroendocrine neoplasms grade 3

Author

Kakiuchi, Nobuyuki, primary, Yoshida, Kenichi, additional, Shiozawa, Yusuke, additional, Yokoyama, Akira, additional, Kataoka, Keisuke, additional, Inoue, Yoshikage, additional, Takeuchi, Yasuhide, additional, Hirano, Tomonori, additional, Fujii, Yoichi, additional, Ueno, Hiroo, additional, Hijioka, Susumu, additional, Mizuno, Nobumasa, additional, Hosoda, Waki, additional, Yatabe, Yasushi, additional, Chiba, Kenichi, additional, Tanaka, Hiroko, additional, Shiraishi, Yuichi, additional, Miyano, Satoru, additional, Masui, Toshihiko, additional, Uemoto, Shinji, additional, Yoshizawa, Akihiko, additional, Haga, Hironori, additional, Uza, Norimitsu, additional, Seno, Hiroshi, additional, Kodama, Yuzo, additional, and Ogawa, Seishi, additional

Published
2019
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49. Abstract 3322: Chronology and risk-dependence of age-related remodelling of oesophageal epithelia

Author

Yokoyama, Akira, primary, Kakiuchi, Nobuyuki, additional, Yoshizato, Tetsuichi, additional, Nannya, Yasuhito, additional, Suzuki, Hiromichi, additional, Takeuchi, Yasuhide, additional, Shiozawa, Yusuke, additional, Sato, Yusuke, additional, Aoki, Kosuke, additional, kim, Soo, additional, Fujii, Yoichi, additional, Yoshida, Kenichi, additional, Kataoka, Keisuke, additional, Nakagawa, Masahiro M., additional, Inoue, Yoshikage, additional, Hirano, Tomonori, additional, Shiraishi, Yuichi, additional, Chiba, Kenichi, additional, Tanaka, Hiroko, additional, Sanada, Masashi, additional, Ohashi, Shinya, additional, Miyamoto, Shin’ichi, additional, Tsunoda, Shigeru, additional, Mimori, Koshi, additional, Minamiguchi, Sachiko, additional, Miyano, Satoru, additional, Makishima, Hideki, additional, Muto, Manabu, additional, and Ogawa, Seishi, additional

Published
2019
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50. A novel technique for mapping biopsy of bile duct cancer.

Author

Okada, Hirokazu, Uza, Norimitsu, Matsumori, Tomoaki, Matsumoto, Shimpei, Muramoto, Yuya, Ota, Sakiko, Nakamura, Takeharu, Yoshida, Hiroyuki, Hirano, Tomonori, Kuwada, Takeshi, Marui, Saiko, Sogabe, Yuko, Morita, Toshihiro, Kakiuchi, Nobuyuki, Mima, Atsushi, Ueda, Tatsuki, Nishikawa, Yoshihiro, Tsuda, Motoyuki, Maruno, Takahisa, and Shiokawa, Masahiro

Subjects
CHOLANGIOCARCINOMA, INTRAHEPATIC bile ducts, BIOPSY, BILE duct tumors, ENDOSCOPIC retrograde cholangiopancreatography, BILE ducts
Abstract

BACKGROUND : Accurate preoperative assessment of the longitudinal extension of perihilar cholangiocarcinoma (PHCC) is essential for treatment planning. Mapping biopsies for PHCC remain challenging owing to technical difficulties and insufficient sample amounts. The aim of this study was to investigate the usefulness of a novel technique for mapping biopsies of PHCC. METHODS : Our novel method focused on a biliary stent delivery system for mapping biopsies. Fifty patients with PHCC undergoing endoscopic transpapillary mapping biopsy using the novel method were reviewed from August 2015 to June 2019. RESULTS : The median number of biopsy samples was six (range 1 - 17), and the rate of adequate sampling was 91.4 % (266 /291). Biopsy from the intrahepatic bile duct was possible in 82.0 % of patients (41 /50), and negative margins were confirmed in the resected specimens from 34 /39 patients who underwent surgery (87.2 %). None of the patients had post-endoscopic retrograde cholangiopancreatography pancreatitis. CONCLUSIONS : With our novel method, accurate assessment of the longitudinal extension of PHCC might be expected with minimal trauma to the duodenal papilla. [ABSTRACT FROM AUTHOR]

Published
2021
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