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347 results on '"Hiraga Y"'

1. Clinical Intervention Using Body Shadows for a Patient with Complex Regional Pain Syndrome Who Reported Severe Pain and Self-Disgust Toward the Affected Site: A Case Report

Author

Hirakawa Y, Fujiwara A, Imai R, Hiraga Y, and Morioka S

Subjects
pain, neglect-like symptoms, physical self-disgust, body shadow intervention, body image, Medicine (General), R5-920
Abstract

Yoshiyuki Hirakawa,1 Akira Fujiwara,2 Ryota Imai,3,4 Yuki Hiraga,1,5 Shu Morioka4,6 1Department of Rehabilitation, Fukuoka Rehabilitation Hospital, Fukuoka City, Fukuoka, Japan; 2Department of Orthopedics, Fukuoka Reha Orthopedic Clinic, Fukuoka City, Fukuoka, Japan; 3School of Rehabilitation, Osaka Kawasaki Rehabilitation University, Kaizuka City, Osaka, Japan; 4Department of Occupational Therapy, International Univesrity of Health and Welfare, Okawa,Fukuoka, Japan; 5Neurorehabilitation Research Centre, Kio University, Nara, City, Nara, Japan; 6Department of Neurorehabilitation, Graduate School of Health Sciences, Kio University, Nara City, Nara, JapanCorrespondence: Yoshiyuki HirakawaDepartment of Rehabilitation, Fukuoka Rehabilitation Hospital, 7-770 Nokata, Nishi-ku, Fukuoka City 819-8551, Fukuoka, JapanTel +81 92 812-1555Fax +81 92 811-0330Email yutsuki0903@yahoo.co.jpAbstract: A woman in her thirties developed complex regional pain syndrome in her left shoulder due to a traffic accident. She demonstrated autonomic nervous symptoms (swelling, sweating, and skin color asymmetry) in her left hand, severe allodynia, neglect-like symptoms (NLS), impaired body image associated with impaired body awareness, and functional impairment of the left shoulder and elbow. She also reported physical self-disgust toward her affected limb, describing it as “reptilian,” as well as aversion to touching others; this body awareness exacerbated her pain and NLS. We therefore conducted stepwise interventions using body shadows. The intervention did not trigger physical self-disgust, enabling formation of body ownership and a body image unaccompanied by pain. Consequently, the patient showed improvements in pain, NLS, and autonomic nervous symptoms.Keywords: pain, neglect-like symptoms, physical self-disgust, body shadow intervention, body image

Published
2020

5. Drug repositioning of antipsychotic drugs for cisplatin-induced pica behavior in mice

Author

Sekiguchi, M., Sagano, N., Kawazoe, H., Hiraga, Y., Jibiki, A., Yokoyama, Y., Suzuki, S., and Nakamura, T.

Abstract

We aimed to clarify whether various antipsychotics ameliorate cisplatin-induced pica behavior in mice using a drug repositioning approach. Mice were administered cisplatin (12.5 mg/kg,i.p.) with or without olanzapine (1 mg/kg,i.p.), asenapine (4 mg/kg,i.p.), mirtazapine (5 mg/kg,i.p.) or standard three-drug antiemetics (granisetron [0.5 mg/kg,i.p.], fosaprepitant [25 mg/kg,i.p.], and dexamethasone [3 mg/kg,i.p.]). Kaolin, food, and water intake, and spontaneous motor activity on the day before and seven consecutive days after the cisplatin administration were measured using a telemetry system. At the primary endpoint, kaolin intake was significantly higher at day three in the cisplatin group than in the pre-treatment and saline groups (p< 0.05). Additionally, kaolin intake was not significantly higher in cisplatin with olanzapine, asenapine, and mirtazapine groups for seven days than in the pre-treatment group. At the secondary endpoint, cisplatin decreased the food and water intake, and spontaneous motor activity in a time-dependent manner. Three antipsychotics failed to improve the cisplatin-induced decrease in food and water intake, and spontaneous motor activity. The findings suggest that prophylactic administration of antipsychotics besides olanzapine may improve cisplatin-induced nausea and vomiting in a delayed phase and de-escalate standard 3-drug antiemetics.

Published
2021
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10. TBLB as a Diagnostic Procedure for Sarcoidosis in Japan — A Cooperative Study in Twenty-Four Hospitals

Author

Honda, K., Kado, M., Izumi, T., Osaki, T., Hiraga, Y., Iwai, K., Yoneda, R., Washizaki, M., Homma, H., Kabe, J., Osada, H., Okano, H., Furuie, T., Hosoda, H., Ito, Y., Hirasawa, K., Mochizuki, I., Sato, A., Yamamoto, Y., Amitani, R., Mikami, R., Kurihara, N., Tachibana, T., Hitomi, S., Ochi, N., Kitatani, F., Nakai, J., Yamakido, M., Shima, K., Miyagi, S., Nakhosteen, John A., editor, and Maassen, Werner, editor

Published
1981
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11. Familial sarcoidosis in Finland and Hokkaido, Japan–a comparative study

Author

Hiraga Y, Olof Selroos, Anne Pietinalho, Michio Hirasawa, Ohmichi M, and A B Löfroos

Subjects
Adult, Family Health, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Systemic disease, Pediatrics, Sarcoidosis, business.industry, Public health, Disease, medicine.disease, Prognosis, Pedigree, Family member, Japan, Epidemiology, medicine, Humans, Female, business, Finland
Abstract

Two or more cases of sarcoidosis in one family is not unusual. To compare the frequencies of familial sarcoidosis in Finland and Hokkaido, Japan, and to analyse the type of associations reported, we collected data on all patients visiting hospitals for sarcoidosis in 1984 in Finland (1378 patients) and Hokkaido (208 patients), including information about familial sarcoidosis. We also analysed the familial cases seen among 571 sarcoidosis patients diagnosed at the Mjölbolsta hospital in Finland from 1955 to 1987 and among 686 Japanese patients seen in Sapporo from 1964 to 1988.In 1984, 50 sarcoidosis patients visiting Finnish hospitals and nine sarcoidosis patients in Hokkaido reported as familial cases. Of the sarcoidosis patients seen in Finland at the Mjolbolsta hospital in 1955–1987, 27 had a family member with the same disease, while this number was 20 in the Sapporo hospital in 1964–1988.Those surveys give a prevalence of familial sarcoidosis in Finland of 3·6–4·7% and in Hokkaido of 2·9–4·3%. Among familial cases, the dominating relationships were sister–brother and mother–child relationships.

Published
1999
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13. Simplicial elimination schemes, extremal lattices and maximal antichain lattices

Author

O. Selroos, Hiraga Y, A B Löfroos, A Pietinalho, and Ohmichi M

Subjects
Discrete mathematics, Erythema nodosum, medicine.medical_specialty, Algebra and Number Theory, medicine.diagnostic_test, Retrospective cohort study, medicine.disease, Computational Theory and Mathematics, Internal medicine, Joint pain, medicine, Geometry and Topology, Sarcoidosis, Differential diagnosis, medicine.symptom, Stage (cooking), Chest radiograph, Mathematics, Bilateral hilar lymphadenopathy
Abstract

We compared the clinical picture of sarcoidosis in patients diagnosed at Mjolbolsta hospital in Finland in 1955-1987 with those diagnosed in Sapporo in 1964-1988. The female:male ratios showed a slight female predominance. The mean age (SD) at diagnosis was 41.5 (13.0) years at Mjolbolsta and 30.0 (15.4) years in Sapporo. In both series, half of the patients had been detected at mass x-ray surveys. The presenting symptoms varied considerably among the symptomatic patients. At Mjolbolsta hospital, 189 patients (33%) had cough, 21% fever, 21% general malaise, 18% dyspnoea, 18% erythema nodosum, 16% joint pain and only 27 patients (5%) had eye symptoms. In Sapporo, 245 patients (41%) had eye symptoms, 18 (4%) had enlarged peripheral lymph nodes, 14 (3%) had cough, 10 (2%) had fever. Erythema nodosum did not occur as a presenting symptom in Sapporo. The chest radiographs showed bilateral hilar lymphadenopathy (BHL, stage I) in 48% of the Mjolbolsta patients and in 57% of the Sapporo patients. Stage II lesions were seen in 39% and 20%, and stage III lesions in 12% and 5% respectively. Only 1% had a normal chest radiograph at Mjolbolsta hospital as compared with 18% in Sapporo. The Sapporo patients were more obstructive but the proportion of smokers was also higher. No difference in diffusion capacity was seen.

Published
1996

46. Endoscopic treatment of submucosal invasive colorectal carcinoma with special reference to risk factors for lymph node metastasis.

Author

Tanaka, Shinji, Haruma, Ken, Teixeira, Claudio, Tatsuta, Shigehiko, Ohtsu, Naoya, Hiraga, Yuko, Yoshihara, Masaharu, Sumii, Koji, Kajiyama, Goro, Shimamoto, Fumio, Tanaka, S, Haruma, K, Teixeira, C R, Tatsuta, S, Ohtsu, N, Hiraga, Y, Yoshihara, M, Sumii, K, Kajiyama, G, and Shimamoto, F

Abstract

A clinicopathological analysis of the risk factors for lymph node metastasis was performed in 177 patients with submucosal invasive colorectal carcinoma (CRC). The submucosal deepest invasive portion was histologically subclassified as well (W), moderately (M), or poorly (Por) differentiated. M type was further subdivided into moderately-well (Mw) and moderately-poorly (Mp) differentiated. The pattern of tumor growth was classified as polypoid growth (PG) and non-polypoid growth (NPG). Lymph node metastasis was detected in 21 (12%) of the 177 patients. Macroscopically, type IIc and IIa + IIc lesions showed a significantly higher incidence of lymph node metastasis (44% and 30%) than type IIa and I (4% and 8%). Regarding the histologic subclassification, Por and Mp lesions showed a significantly higher incidence of lymph node metastasis (67% and 37%) than W and Mw lesions (4% and 14%). NPG tumors showed a significantly higher incidence of lymph node metastasis (29%) than PG tumors (7%). The depth of submucosal invasion and lymphatic invasion (ly) were also significantly correlated with the incidence of lymph node metastasis (submucosal scanty (sm-s) invasion 4%, massive invasion 20%; ly(+) 23%, ly(-) 5%). None of the lesions with both sm-s invasion and of W or Mw type showed lymph node metastasis. These results indicate that submucosal invasive CRC with both sm-s invasion and of W or Mw type, which shows no ly, is the appropriate indication for endoscopic curative treatment. [ABSTRACT FROM AUTHOR]

Published
1995
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47. Subretinal neovascularisation and snow banking in a case of sarcoidosis: case report.

Author

Pellegrini, V., Ohno, S., Hirose, S., Matsuda, H., and Hiraga, Y.

Abstract

A 49-year-old Japanese man presented with chronic granulomatous uveitis in his left eye. Later he developed macular subretinal neovascularisation. The chest x-ray showed bilateral hilar lymphadenopathy. Bronchoscopy and gallium-67 scanning were positive, PPD skin test negative, and serum angiotensin converting enzyme (ACE) levels increased. Ophthalmoscopy and fluorescein angiography of the left eye showed perivasculitis, retinochoroidal exudates, snow banking, and vitreous opacity. On these findings, the diagnosis of sarcoidosis was made. Treatment was based on topical corticosteroids, mydriatics, beta blockers, and oral carbonic anhydrase inhibitors. After 15 months the visual acuity decreased in the left eye, and a neovascular membrane was observed in the macula. Fluorescein angiography confirmed subretinal neovascularisation. Almost two years later the patient still has the neovascular membrane in his left eye. [ABSTRACT FROM PUBLISHER]

Published
1986

48. Comparative Clinical Study of Cefcapene Pivoxil and Cefteram Pivoxil in Chronic Respiratory Tract Infections by a Double-blind Method

Author

Saito, A, Hiraga, Y, Watanabe, A, Saito, A, Shimada, K, Kobayashi, H, Odagiri, S, Miki, F, Soejima, R, Oizumi, K, Hara, K, Nakashima, M, and Sasaki, Shimaru

Abstract

In a double-blind study, the efficacy and safety of the novel cephem antibiotic cefcapene pivoxil (CFPN-PI; 450 mg/day) was compared with cefteram pivoxil (CFTM-PI; 600 mg/day) in 171 patients with chronic respiratory tract infections. There was no significant difference between the clinical efficacy of the two drugs (80.2% for CFPN-PI versus 78.9% for CFTM-PI). There was no significant difference in the rate of elimination of the causative bacteria (60.5% for CFPN-PI versus 65.9% for CFTM-PI). Side-effects were observed in 6.0% of patients treated with CFPN-PI compared with 6.4% of patients treated with CFTM-PI. There were no significant differences in incidence of abnormal laboratory findings following treatment with the two drugs (13.9% for each), and none of the side-effects was severe. We conclude that CFPN-PI (450 mg/day) was as effective and as well tolerated as CFTM-PI (600 mg/day) in the treatment of chronic respiratory tract infections.

Published
2004
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