132 results on '"Hipopotasemia"'
Search Results
2. Maximum serum K+ concentration within 1 hour with enteral replacement in severe hypokalemia.
- Author
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Yépez Florián, Juan de Dios and Yépez Figueroa, Gabriela Estefanía
- Subjects
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HYPOKALEMIA , *MULTIPLE myeloma , *LUMBOSACRAL plexus , *SYMPTOMS , *POTASSIUM , *SPINE - Abstract
Introduction: we report two cases with severe hypokalemia. Patients and Methods: a 68-year-old woman was admitted with lower limb swelling and urinary symptoms; on the fourth day serum K+ concentration (s[K+]) was 2.3 mmol/L. A 64-year-old woman was admitted with pain in the lumbosacral spine, she was diagnosed with multiple myeloma. After receiving specific therapy she showed s[K+] at 2.4 mmol/L. A KCl solution containing 26.8 mEq of K+ was administered enterally, which increased s[K+] by 0.7 mmol/L within 1 h. Results and Conclusion: these cases reveal that peak s[K+] may be achieved within 1 hour after KCl intake in severe hypokalemia, which is probably faster than IV administration. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Hiperaldosteronismo primario, una patología frecuente e infradiagnosticada: presentación de un caso.
- Author
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González-Clavijo, Angélica María, Buitrago-Bermeo, Andrés Felipe, and Cárdenas-Mesa, Juan Diego
- Subjects
THERAPEUTICS ,ANTIHYPERTENSIVE agents ,CARDIOVASCULAR diseases ,PHYSICIANS ,INTRAVENOUS catheterization - Abstract
Copyright of Médicas UIS is the property of Universidad Industrial de Santander and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
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4. Aproximación terapéutica a los trastornos del potasio.
- Author
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Herrera-Añazco, Percy, Rivas-Nieto, Andrea C., Chang-Dávila, Domingo, and Lluncor Vásquez, Juan
- Abstract
Potassium is an essential cation for multiple physiological processes and potassium disorders, also known as dyskalemias, imply an increased risk of cardiovascular and neurological complications. The present review aims to outline the main strategies for the management of patients with potassium disorders in the hospital setting. For the management of hyperkalemia, we propose that the therapeutic approach should include etiologic evaluation, evidence-based pharmacologic management, monitoring of therapeutic response, and timely decision on initiation of dialysis. For hypokalemia, we suggest initial assessment of severity, pharmacologic management, and monitoring of response to therapy. Despite the limitations of the primary evidence for the management of potassium disorders, the present recommendations emphasize practices based on the best available evidence. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Diagnóstico de parálisis periódica tirotóxica posterior a la administración de corticosteroide sistémico: presentación de un caso.
- Author
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Ochoa-Magdaleno, Jorge, Salgado-Gómez, Eduardo, and Contreras-García, Carlos
- Subjects
HYPERTHYROIDISM diagnosis ,ADRENOCORTICAL hormones ,PARALYSIS ,DEXAMETHASONE ,WATER-electrolyte balance (Physiology) ,GRAVES' disease ,INTRAMUSCULAR injections ,MUSCLE weakness ,HYPOKALEMIA ,THYROID crisis - Abstract
Copyright of Revista Mexicana de Endocrinología, Metabolismo y Nutrición is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
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6. Parálisis periódica hipopotasémica tirotóxica: reporte de un caso.
- Author
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Claros Espinoza, Karen Griselda
- Subjects
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DELAYED diagnosis , *HYPERTHYROIDISM , *SYMPTOMS , *PARALYSIS , *CHRONIC diseases , *HYPOKALEMIA - Abstract
Thyrotoxic Hypokalemic Periodic paralysis (PPHT) is a rare complication of hyperthyroidism. The case of a 50-year-old patient with no previous history of chronic diseases is presented, who presented recurrent episodes of weakness and quadriparesis, with normokalemia and without obvious symptoms of hyperthyroidism, which delayed the diagnosis of thyrotoxic periodic paralysis, until the frank presentation of hypokalemia. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
7. Anomalías bioquímicas y hematológicas en la intoxicación grave por organofosforados. Estudio prospectivo en un solo centro.
- Author
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Hussain Parrey, Ashaq, Kasana, Basharat, Ajaz, Abir, Ismail, Mohd, Koka, Manzoor, Ashraf, Mohd, and Shafi, Isma
- Subjects
OXYGEN saturation ,BLOOD sugar ,POISONING ,HYPOXEMIA ,LEAD poisoning - Abstract
Copyright of Galicia Clínica is the property of Sociedad Gallega de Medicina Interna and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
- Full Text
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8. Hipopotasemia genética refractaria en la edad adulta
- Author
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Adriana Bandeira, Miguel Gonzalez Santos, Behnam Moradi, Alcina Ponte, and Paula Costa
- Subjects
síndrome de bartter ,hipopotasemia ,bsnd ,Medicine ,Internal medicine ,RC31-1245 - Abstract
Hypokalemia, despite its potential seriousness, is frequently encountered in clinical practice; with the majority of cases occurring in adulthood being rationalized by examining the triad losses: diuretics, vomiting and diarrhea, as inherited causes of hypokalemia with later onset are uncommon. Below we report a case of chronic and recurrent mild hypokalemia, in an adult patient with idiopathic congenital deafness. Early clinical and analytical findings pointed to a hereditary syndrome with augmented potassium renal excretion. Suspicion of a likely molecular basis motivated the analysis of the barttin’s gene, revealing a G47R mutation in heterozygosity as well as a second mutation within an usually unaltered area. G47R mutation when in homozygosity is associated with an attenuated BSND (Bartter syndrome accompanied by sensorineural deafness) phenotype, questioning the clinical significance of the second mutation discovered.
- Published
- 2022
- Full Text
- View/download PDF
9. Taquicardia ventricular monomórfica no sostenida asociada con hipopotasemia por uso de fludrocortisona: presentación de caso y revisión de la literatura.
- Author
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Zambrano Jiménez, Rafael Antonio and Niño Mahecha, Freyberson Enrique
- Abstract
Copyright of Universitas Médica is the property of Pontificia Universidad Javeriana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
- Full Text
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10. Refractory genetic hypokalemia in adulthood.
- Author
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Gaspar Bandeira, Adriana Sofia Graça, Costa, Paula, Moradi, Behnam, and Ponte, Alcina
- Subjects
SENSORINEURAL hearing loss ,TREATMENT of hypokalemia ,DIURETICS ,IDIOPATHIC diseases ,GENETICS of deafness ,GENETIC mutation ,HOMOZYGOSITY ,DEAFNESS ,PHENOTYPES ,BARTTER syndrome ,HYPOKALEMIA - Abstract
Hypokalemia, despite its potential seriousness, is frequently encountered in clinical practice; with the majority of cases occurring in adulthood being rationalized by examining the triad losses: diuretics, vomiting and diarrhea, as inherited causes of hypokalemia with later onset are uncommon. Below we report a case of chronic and recurrent mild hypokalemia, in an adult patient with idiopathic congenital deafness. Early clinical and analytical findings pointed to a hereditary syndrome with augmented potassium renal excretion. Suspicion of a likely molecular basis motivated the analysis of the barttin's gene, revealing a G47R mutation in heterozygosity as well as a second mutation within an usually unaltered area. G47R mutation when in homozygosity is associated with an attenuated BSND (Bartter syndrome accompanied by sensorineural deafness) phenotype, questioning the clinical significance of the second mutation discovered. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
11. Perfil clínico-epidemiológico de pacientes con parálisis periódica tirotóxica en dos hospitales peruanos.
- Author
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Luis Paz-Ibarra, José, Mabel Sáenz-Bustamante, Sofia, Pilar Ildefonso-Najarro, Sofía, Portillo-Flores, Karina, Alejandra Quispe-Flores, María, Alberto Plasencia-Dueñas, Esteban, and José Concepción-Zavaleta, Marcio
- Abstract
Background: Thyrotoxic Periodic Paralysis (PPT) is an uncommon complication of hyperthyroidism, it is the most frequent cause of acute flaccid paralysis in adults. Material and methods: A retrospective observational study was carried out in 2 reference hospitals of the social security in Lima-Peru, which included 22 patients diagnosed with PPT during the period 2014-2021. Results: the average age at diagnosis was 35.77 ± 9.6 years, all of mixed race, in 82% of the patients the diagnosis of hyperthyroidism was established from this entity, the etiology in 95% was autoimmune (Graves-Basedow) except for one whose etiology was toxic multinodular goiter. The triggering event reported in 54% of patients was the intake of copious food high in carbohydrates, followed by exercise (27%), the most frequent presentation time was during the morning (41% of the cases), the main weakness pattern compromised lower limbs (45% paraplegia, 18% paraparesis), only 36% were diagnosed with PPT in their first episode of motor weakness. Conclusions: We consider that this condition should be suspected in any young male patient of any ethnicity with acute muscle weakness, associated with low serum potassium levels and symptoms of thyrotoxicosis, although its absence should not rule out the diagnosis. The precipitating factor should be identified as much as possible and initial therapy with propanolol with or without intravenous or oral potassium replacement should be established, with adequate subsequent monitoring to minimize the risk of rebound hyperkalemia. [ABSTRACT FROM AUTHOR]
- Published
- 2022
12. Trends of Serum Electrolyte Levels toward Severity Rates in COVID-19 Patients with Type 2 Diabetes Mellitus Comorbidity in Dr. Soetomo Hospital Surabaya.
- Author
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Hamidah, Soelistijo, Soebagijo Adi, Triyono, Erwin Astha, Pranoto, Agung, and Miftahussurur, Muhammad
- Subjects
TYPE 2 diabetes ,TYPE 2 diabetes complications ,COVID-19 ,COVID-19 testing ,COMORBIDITY ,COVID-19 pandemic ,BLOOD serum analysis ,ACUTE kidney failure ,SEVERITY of illness index ,PROTEINURIA - Abstract
Copyright of Gaceta Médica de Caracas is the property of Academia Nacional de Medicina and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
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13. Hipercortisolismo severo e hipocalemia recurrente
- Author
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Alejandro Pinzon-Tovar, Marly Oviedo-Cali, Silvana Jimenez-Salazar, Harold Mendez, and Kenny Buitrago-Toro
- Subjects
Síndrome de Cushing ,Hipersecreción de la Hormona Adrenocorticotrópica Pituitaria (HACT) ,Hipopotasemia ,Adenocorticotropina ,Tumores Neuroendocrinos ,Medicine - Abstract
El síndrome de Cushing endógeno deriva de un aumento crónico, inapropiado y sostenido de glucocorticoides principalmente como respuesta al exceso en las concentraciones séricas elevadas de la hormona adrenocorticotropa (ACTH) desde un tumor adenohipofisiario, enfermedad de Cushing; o producida de forma ectópica por tumores neuroendocrinos. El Cushing suprarrenal se origina por tumores de la corteza adrenal que producen de forma autónoma cortisol y es independiente de ACTH. El curso clínico, tratamiento, pronóstico y posibles complicaciones dependen de identificar de forma correcta la lesión desencadenante; situación que en múltiples ocasiones resulta en una experiencia retadora para los clínicos. Se presenta el caso de una mujer de 62 años, ingresada por síntomas constitucionales con hipocaliemia severa de difícil corrección e hipercortisolismo severo.
- Published
- 2022
- Full Text
- View/download PDF
14. Abordaje de hipertensión secundaria en adultos mayores: reporte de caso.
- Author
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Sofia Palomino-Pacichana, Diana, Mauricio Ocampo-Chaparro, José, Reyes-Ortiz, Carlos A., and Ángela Casas, Luz
- Subjects
MAGNETIC resonance imaging ,BLOOD pressure ,ANTIHYPERTENSIVE agents ,PATHOLOGY ,HYPERALDOSTERONISM ,SYMPTOMS ,HYPOKALEMIA - Abstract
Copyright of Médicas UIS is the property of Universidad Industrial de Santander and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
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15. Hipokalemia y muerte súbita cardiaca en personas sin enfermedad cardiaca estructural: Presentación de caso y revisión sistemática.
- Author
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Dante Meregildo-Rodriguez, Edinson, Genara Asmat-Rubio, Martha, and Adolfo Vásquez-Tirado, Gustavo
- Abstract
Introduction: The aim of this study was to synthesize the evidence on the causes of sudden cardiac death (SCD) associated with hypokalemia in individuals ≥15 to <65 years of age without structural heart disease. Case report. We reported a case and collected SCD cases following the PECO strategy. We conducted a bibliographic search of the literature published up to November 30, 2021. We included 25 cases. The mean age was 33.8 ± 2.4 years. Of the total cases, 60% were male and 60% corresponded to acquired etiologies. Thyrotoxicosis was the etiology of 8% of cases. The QTc interval was prolonged in 90% of the cases in which it could be recorded. Sixty percent of cases occurred out of hospital. Only 24% of episodes resulted in death. Conclusions. Thyrotoxicosis is a rare cause of hypokalemic sudden cardiac arrest (SCA). Hypokalemic SCA seems to be associated with better clinical results compared to SCA associated with hyperkalemia or normokalemia. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
16. Seudohipoparatiroidismo asociado con síndrome de Gitelman. Reporte de un caso.
- Author
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Saavedra-López, Harold Felipe and Meléndez-Rhenals, Sugeich
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SPASMS ,GENETIC disorders ,GENETIC disorder diagnosis ,BLOOD pressure ,HYPOCALCEMIA ,HYPOKALEMIA ,PARESTHESIA - Abstract
Copyright of Revista Facultad de Medicina de la Universidad Nacional de Colombia is the property of Universidad Nacional de Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
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17. Hipercortisolismo severo e hipocalemia recurrente.
- Author
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Pinzon-Tovar, Alejando, Oviedo-Cali, Marly, Jimenez-Salazar, Silvana, Mendez, Harold, and Buitrago-Toro, Kenny
- Subjects
CUSHING'S syndrome ,ADRENAL cortex ,ADRENOCORTICOTROPIC hormone ,ADRENAL tumors ,NEUROENDOCRINE tumors ,HYPOKALEMIA - Abstract
Copyright of Acta Médica Peruana is the property of Colegio Medico del Peru and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
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18. Parálisis periódica hipopotasémica. Presentación de un caso
- Author
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Carlos García Gómez, Samuel Sánchez Sánchez, and Gretel Ruíz Martínez
- Subjects
parálisis periódica hipopotasémica ,enfermedades neuromusculares ,debilidad muscular ,hipopotasemia ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
La parálisis periódica hipopotasémica generalmente es causada por mutaciones autosómicas dominantes en el gen del canal de calcio dependiente del voltaje; las crisis de debilidad, suelen persistir durante horas o días antes de resolverse gradualmente; el nivel de potasio sérico puede estar bajo o normal durante la crisis. Este trastorno puede presentarse de forma adquirida en afecciones como pérdidas digestivas de potasio, diuréticos depletantes de potasio, entre otras. Se describe el caso de un paciente de piel blanca, de 53 años de edad, que acudió a consulta por pérdida de la fuerza muscular en los cuatro miembros, y reflejos osteotendinosos conservados. En los complementarios solo llamó la atención los bajos valores de potasio sérico (1,99 mmol/L). La escasa frecuencia con que se presenta este trastorno, la forma de presentación en este paciente, y la probabilidad de confundirlo con otras enfermedades, motivaron la publicación del artículo.
- Published
- 2020
19. Gitelman syndrome, a rare cause of refractory hypokalemia. A case report.
- Author
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Zambrano-Urbano, Jose Leonel, Delgado-Truque, Andrés Emilson, Ocampo-Chaparro, José Mauricio, and Castro-Flórez, Ximena
- Subjects
HYPOKALEMIA ,SYNDROMES ,ASYMPTOMATIC patients ,SALT ,EMERGENCY medical services ,DIFFERENTIAL diagnosis - Abstract
Copyright of Revista Facultad de Medicina de la Universidad Nacional de Colombia is the property of Universidad Nacional de Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
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20. Parálisis periódica hipocalémica tirotóxica
- Author
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Jhoan Emmanuel Orjuela Quiroga, Lilibeth Celly Abarca, Bella Halisd Gómez Pérez, Martín Ocampo Posada, and Leopoldo Garcés Villabón
- Subjects
hipopotasemia ,enfermedades neuromusculares ,enfermedades musculares ,hipertiroidismo ,hipocalemia ,parálisis periódica hipocalémica ,Medicine (General) ,R5-920 - Abstract
Introducción: las parálisis periódicas son desórdenes neuromusculares dentro de los cuales se encuentra la hipocalémica, que puede ser primaria o secundaria. De especial interés es la hipocalémica tirotóxica por su baja sospecha en el hemisferio occidental. Presentación: paciente que acudió al servicio de urgencias de una clínica en Cali, Colombia aquejando la triada clásica de esta entidad y quien tras recibir tratamiento óptimo resolvió por completo su cuadro clínico. Discusión: se hace énfasis en los hallazgos en la literatura universal y su similitud con el cuadro del paciente. Conclusión: se destaca la importancia de estudios epidemiológicos que analizan la prevalencia e incidencia de esta enfermedad en nuestro país y la importancia de concebir esta entidad como sospecha clínica dado que se trata de una emergencia médica.
- Published
- 2021
21. Parálisis periódica tirotóxica. Reporte de un caso
- Author
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Patricia Sobarzo and Victor Vergara
- Subjects
hipopotasémia ,tirotoxicosis ,parálisis ,hipertiroidismo. ,Medicine (General) ,R5-920 - Abstract
La parálisis periódica tirotóxica (PPTH) esuna afección esporádica que se presenta con debilidad muscular recurrente y transitoria e hipocalemia severa en pacientes con tirotoxicosis, se presenta este caso ya que es una complicación muy rara del hipertiroidismo más aún cuando se presenta como debut de la enfermedad de Graves Basedow. El objetivo es presentar las características clínicas, tratamiento y la evolución de un paciente con parálisis tirotóxica. El paciente iniciósíntomas de la enfermedad de Graves Basedow, con una parálisis periódica hipopotasémica, que mejorórápidamente con la corrección del déficit de potasio (K+) por vía intravenosa. Se deben identificar correctamente las patologías que se presentan con debilidad de miembros superiores e inferiores, ya que fácilmente se pueden confundir con otras enfermedades que necesitan diagnóstico y tratamiento diferentes y más agresivos.
- Published
- 2020
22. VIPoma: a rare cause of diarrhea. A case report.
- Author
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María Sánchez-Salazar, Sara, Torres-Alzate, Santiago, Marcela Muñoz-Cortés, Viviana, Alfonso Builes-Barrera, Carlos, Iván Gutiérrez-Montoya, Jorge, and Román-González, Alejandro
- Subjects
HYPOKALEMIA ,VASOACTIVE intestinal peptide ,DIARRHEA ,SYMPTOMS ,DELAYED diagnosis ,ACIDOSIS - Abstract
Copyright of Revista Facultad de Medicina de la Universidad Nacional de Colombia is the property of Universidad Nacional de Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
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23. Paro cardiorrespiratorio presuntamente secundario a la administración de ondansetrón en paciente con trastorno electrolítico.
- Author
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Mamani Mamani, Clemente Eloy
- Subjects
- *
VENTRICULAR arrhythmia , *SUDDEN death , *ONDANSETRON , *FLUID therapy , *ANTIEMETICS - Abstract
Ondansetron belongs to a class of medications called 5HT3 receptor antagonists with antiemetic use indicated for the control of nausea induced by chemotherapy, radiotherapy, and surgery. This medication has been associated with very few serious side effects. Currently, Ondansetron has been linked to cases of ventricular arrhythmias and sudden death. This case is of a 67-year-old male patient treated in the emergency department for a chronic hypokalemia, treated with fluid therapy, ranitidine, amlodipine, and ondansetron in a time of 20 minutes, after the administration of the latter, he presented with sudden death. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
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24. Insuficiencia respiratoria asociada con la hipomagnesemia extrema en un paciente con colitis ulcerativa. Reporte de caso y revisión de la literatura.
- Author
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Esteban Arias-Mira, David and Alfonso Camacho-Ojeda, Luis
- Published
- 2021
- Full Text
- View/download PDF
25. Interacciones potenciales entre productos fitoterápicos con laxantes antracénicos y otros fármacos. Detección en farmacias comunitarias de Sevilla
- Author
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Caballero Barbero F, García Giménez MD, and Quílez Guerrero AM
- Subjects
fitoterapia ,farmacología ,atención farmacéutica ,laxantes ,hipopotasemia ,Pharmacy and materia medica ,RS1-441 - Abstract
Introducción: Los productos fitoterápicos más dispensados en España son los laxantes. Los laxantes antracénicos como el acíbar de aloe (Aloe spp.) o la corteza de cáscara sagrada (Rhamnus purshianus), entre otros, podrían estar implicados en interacciones farmacológicas debido al riesgo de hipopotasemia que produce su uso continuado. Objetivos: Realizar un análisis de la situación de dispensación de estos laxantes y detectar potenciales interacciones con otros fármacos en farmacias de la Provincia de Sevilla. Material/Métodos: Estudio descriptivo, observacional, realizado desde 14 farmacias comunitarias, mediante aplicación de un cuestionario acerca del uso de plantas medicinales. Se identificaron las interacciones potenciales descritas en las monografías EMA y ESCOP, y se analizaron los factores de riesgo para las mismas (edad avanzada, polimedicación y frecuencia de consumo). Resultados: La muestra fue constituida por 252 pacientes. El 24,6% (n=62) consumían laxantes antracénicos, más del 50% de forma diaria. El porcentaje de asociación con otros fármacos fue del 70%. Se han identificado potenciales interacciones en el 40% (n=26) de los pacientes, basadas en la asociación del laxante con fármacos diuréticos, con fármacos que podrían prolongar el intervalo QT, o con ambos a la vez. En todos ellos se detectó la existencia de uno o varios Factores de Riesgo para la Interacción (FRI). Conclusiones: Los resultados obtenidos reflejan la necesidad de formación actualizada por parte de los farmacéuticos comunitarios sobre los beneficios y riesgos de estos fitomedicamentos. Su dispensación protocolizada favorecería la identificación de posibles interacciones farmacológicas y su uso seguro y racional.
- Published
- 2018
- Full Text
- View/download PDF
26. Early hypophosphataemia in at risk newborns. Frequency and magnitude
- Author
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Gerardo Bustos Lozano, Álvaro Hidalgo Romero, Ana Melgar Bonis, Noelia Ureta Velasco, Carlos Orbea Gallardo, and Carmen Pallás Alonso
- Subjects
Hipofosforemia ,Nutrición parenteral ,Prematuridad ,Hipercalcemia ,Hipopotasemia ,Recién nacido ,Pediatrics ,RJ1-570 - Abstract
Objective: To determine the frequency and magnitude of neonatal hypophosphataemia (32 weeks with weight 32 semanas con peso
- Published
- 2018
- Full Text
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27. Parálisis periódica hipopotasémica. Presentación de un caso.
- Author
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García Gómez, Carlos, Sánchez Sánchez, Samuel, and Ruíz Martínez, Gretel
- Abstract
Hypokalemic periodic paralysis is generally caused by autosomal dominant mutations in the voltage-dependent calcium channel gene; seizures of weakness usually persist for hours or days before gradually resolving; the serum potassium level may be low or normal during the crisis. This disorder can present in an acquired way in conditions such as digestive losses of potassium, potassium-depleting diuretics, among others. The case of a 53-year-old white-skinned patient who came to the clinic due to loss of muscle strength in all four limbs, and preserved osteotendinous reflexes it is describe. In the tests, only the low serum potassium values (1.99 mmol / L) stand out. The rare frequency with which this disorder occurs, the form of presentation in this patient, and the probability of confusing it with other diseases, motivated the publication of the article. [ABSTRACT FROM AUTHOR]
- Published
- 2020
28. hypokalemic Thyrotoxic periodic paralysis
- Author
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Jhoan Emmanuel Orjuela Quiroga, Lilibeth Celly Abarca, Bella Halisd Gómez Pérez, Martín Ocampo Posada, and Leopoldo Garcés Villabón
- Subjects
enfermedades musculares ,Economics and Econometrics ,hipocalemia ,parálisis periódica hipocalémica ,hypokalemic periodic paralysis ,Forestry ,neuromuscular disorders ,hypocalcemia ,muscle disorders ,hipertiroidismo ,hipopotasemia ,hypokalemia ,Materials Chemistry ,Media Technology ,hyperthyroidism ,enfermedades neuromusculares - Abstract
Introducción: las parálisis periódicas son desórdenes neuromusculares dentro de los cuales se encuentra la hipocalémica, que puede ser primaria o secundaria. De especial interés es la hipocalémica tirotóxica por su baja sospecha en el hemisferio occidental. Presentación: paciente que acudió al servicio de urgencias de una clínica en Cali, Colombia aquejando la triada clásica de esta entidad y quien tras recibir tratamiento óptimo resolvió por completo su cuadro clínico. Discusión: se hace énfasis en los hallazgos en la literatura universal y su similitud con el cuadro del paciente. Conclusión: se destaca la importancia de estudios epidemiológicos que analizan la prevalencia e incidencia de esta enfermedad en nuestro país y la importancia de concebir esta entidad como sospecha clínica dado que se trata de una emergencia médica.
- Published
- 2022
- Full Text
- View/download PDF
29. Hypokalemic coma: in relation to a case report
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Wilber Riverón-Carralero, Annalie Fidelina Rondón-Vázquez, and Onelis Góngora-Gómez
- Subjects
hipopotasemia ,desequilibrio hidroelectrolítico ,coma ,trastornos de la conciencia ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introduction: coma is the extreme degradation of consciousness. A syndrome characterized by a loss of vegetative functions, as an expression of acute and severe brain dysfunction. Presentation of the case: a 65-year-old male patient who two years ago commenced showing signs of loss of consciousness for two days In inter-crisis periods the studies did not confirm positive results. He was brought to the emergency room in a state of hyporeflexic coma. All parameters were normal except for a very discrete metabolic alkalosis and severe hypokalemia with 1,3 millimoles of potassium. General measures and complementary examinations were performed. Potassium values were replenished. As the potassium values standardized, a process of consciousness recovery was initiated. It was interpreted as a hypokalemic coma. Conclusions: hypopotassemia is a common imbalance, with repercussions in the different systems; this imbalance can result in alterations of the cardiovascular dynamics, progressive muscle weakness and coma. Therefore, in case of symptoms similar to hypokalemia, it is required to work on its diagnosis and treatment.
- Published
- 2020
30. Emergencia hipertensiva de origen endocrinológico: una afección rara con alivio quirúrgico.
- Author
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Andrés Páez-Guerra, Camilo, Alberto Flores-Hernández, José, Horacio Torres-López, Irving, and Pérez-Cruz, Elizabeth
- Abstract
BACKGROUND: Arterial hypertension secondary to primary hyperaldosteronism is becoming more frequent. Unilateral adrenal adenoma is a common cause of primary hyperaldosteronism, its clinical and biochemical presentation is similar to that of the aldosterone-producing adenoma. CLINICAL CASE: A 59-year-old male patient who attended to the emergency room due to sudden diminishment of muscle strength of right hemibody, limitation of gait, difficulty for articulating words and deviation of the commissure to the left. In imaging studies, computed tomography of the adrenal glands showed a hypodense image between 8-12 UH compatible with right adrenal adenoma of 12 x 16 x 16 mm. CONCLUSION: Although its diagnosis remains a challenge, the importance in the recognition of this disease is that most of the times it allows a specific therapy of surgical and curable type, thus avoiding the deleterious effects of aldosterone in the cardiovascular system and in the beta cells. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
31. SÍNDROME DE GITELMAN.
- Author
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UNGARO, CATALINA M., SILVINA ODSTRCIL-BOBILLO, M., and RUSSO, PAULA M.
- Abstract
Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
32. Coma hipopotasémico: a propósito de un caso.
- Author
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Jesús Riverón-Carralero, Wilber, Fidelina Rondón-Vázquez, Annalie, and Góngora-Gómez, Onelis
- Abstract
Copyright of Universidad Médica Pinareña is the property of Editorial Ciencias Medicas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
33. Mesa Redonda Residentes de Medicina
- Author
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Julio Pertuze R.
- Subjects
Hiperinsulinismo ,Hipopotasemia ,Fibrosis ,Medicine - Abstract
Sin resumen
- Published
- 2018
34. Tema IV. Aspectos Clínicos del Metabolismo del Potasio.
- Author
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Waldemar Badía C.
- Subjects
Potasio ,Hipopotasemia ,Medicine - Abstract
Sin resumen
- Published
- 2018
35. Hiperaldosteronismo Primario: Causa curable de Hipertensión Arterial e Hipokalemia
- Author
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José Manuel López M.
- Subjects
Hiperaldosteronismo ,Hipertensión ,Hipopotasemia ,Medicine - Abstract
Sin resumen
- Published
- 2018
36. Secondary hypertension approach in older adults: a case report
- Author
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Diana Sofia Palomino-Pacichana, José Mauricio Ocampo-Chaparro, Carlos A. Reyes-Ortiz, and Luz Ángela Casas
- Subjects
Hipopotasemia ,Hipertensión ,Anciano ,Hypertension ,Adrenocortical Adenoma ,General Earth and Planetary Sciences ,Hypokalemia ,Adenoma Corticosuprarrenal ,General Environmental Science ,Aged - Abstract
Resumen La hipertensión arterial secundaria es poco frecuente y está asociada con una causa que puede ser tratable, por lo cual su diagnóstico y tratamiento oportuno son importantes. La orientación diagnóstica se hace con base en los datos obtenidos en la anamnesis y examen físico del paciente buscando posibles etiologías. Se presenta el caso de un hombre de 63 años, con hipertensión arterial resistente, sin otra sintomatología ni antecedentes personales o familiares. Se realizaron estudios iniciales que documentaron hipopotasemia, lo que hizo sospechar hiperaldosteronismo primario, se solicitaron pruebas complementarias con aldosterona plasmática elevada, actividad de la renina plasmática baja, además con imagen diagnóstica por resonancia nuclear magnética que mostró nódulo suprarrenal derecho. Se considero llevar a adrenalectomía derecha, con reporte de patología compatible con adenoma cortical adrenal. Durante el seguimiento en atención primaria presento adecuado control en cifras de presión arterial con disminución del número de medicamentos antihipertensivos requeridos. Abstract Secondary arterial hypertension is rare, it is associated with a cause that can be treatable, for which its diagnosis and treatment are not important.The diagnostic orientation is made based on the data obtained in the anamnesis and physical examination of the patient, looking for possible etiologies.We present the case of a 63-year-old man with resistant hypertension, without other symptoms or personal or family history. Initial studies were performed that documented hypokalemia, which led to the suspicion of primary hyperaldosteronism. Complementary tests were requested with high plasma aldosterone, low plasma renin activity, in addition to a diagnostic magnetic resonance imaging that showed an adrenal nodule. A right adrenalectomy was considered, with a report of pathology compatible with adrenal cortical adenoma.During the follow-up in primary care, patient presented adequate control in blood pressure figures with a decrease in the number of antihypertensive drugs required.
- Published
- 2022
37. Hiperaldosteronismo primario asociado a neoplasia adrenal. Reporte de caso
- Author
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Bravo-Zúñiga, Jessica and Neira-Sánchez, Elsa
- Subjects
aldosterone ,Hipopotasemia ,nefrolitiasis ,Hypokalemia ,aldosterona ,nephrolithiasis - Abstract
RESUMEN Se describe el caso de un varón de 68 años con antecedente de hipertensión arterial no tratada, diagnosticada un año antes, que ingresó con un cuadro de anasarca, debilidad muscular y disnea al reposo. Los primeros exámenes realizados mostraron hipopotasemia severa, alcalosis metabólica, litiasis renal y vesical y enfermedad renal crónica. La tomografía abdominal reveló una tumoración suprarrenal derecha, hidronefrosis bilateral y litiasis renal y vesical. Con la sospecha de hiperaldosteronismo primario se completó el estudio, con la determinación de relación aldosterona/concentración de renina directa, que resultó alta. El estudio metabólico arrojó hipercalciuria e hiperuricosuria y la gradiente transtubular de potasio mayor de 7. El paciente fue sometido a tratamiento quirúrgico con nefrectomía derecha, sin embargo, falleció en el postoperatorio inmediato, por shock hipovolémico e insuficiencia respiratoria. SUMMARY We report the case of a 68-year-old male with a history of non-treated arterial hypertension diagnosed the previous year that was admitted with anasarca, muscle weakness and dyspnea at rest. The first laboratory exams showed severe hypopotassemia, metabolic alkalosis, renal and gallbladder lithiasis and chronic renal disease. The abdominal tomography revealed a right suprarenal tumor, bilateral hydronephrosis and renal and gallbladder lithiasis. Under the suspicion of primary hyperaldosteronism, the diagnosis was confirmed with the determination of the relationship between aldosterone/direct renin concentration, which was high. The metabolic study showed hypercalciuria and hyperuricosuria and the potassium trans tubular gradient was above 7. The patient underwent right nephrectomy, nonetheless, died at the immediate post-operatory period due to a hypovolemic shock and respiratory failure.
- Published
- 2022
38. Síndrome de Gitelman, causa rara de hipopotasemia refractaria
- Author
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Zambrano Urbano, Jose Leonel, Delgado-Truque, Andrés Emilson, Ocampo Chaparro, José Mauricio, Castro-Flórez, Ximena, Zambrano Urbano, Jose Leonel, Delgado-Truque, Andrés Emilson, Ocampo Chaparro, José Mauricio, and Castro-Flórez, Ximena
- Abstract
Introduction: Gitelman syndrome is a rare hereditary primary renal tubular disorder, with a prevalence of approximately 1 to 10 cases per 40 000 people. It does not have specific symptoms, so its diagnosis depends on high clinical suspicion by the treating physical and a sequential approach to hypokalemia, especially in young patients. Thus, a diagnostic algorithm is proposed at the end of this report. Case presentation: A 23-year-old woman with a history of hospitalization due to hypokalemia presented to the emergency service with intermittent cramping in her lower limbs, which was exacerbated by gastrointestinal symptoms. Laboratory tests reported the following findings: metabolic alkalosis, elevated levels of potassium, magnesium, chloride and sodium in urine, and reduced levels of calcium in urine. Thus, potassium supplementation and eplerenone administration were started, obtaining the complete resolution of symptoms. At her last follow-up appointment, the patient was asymptomatic, and her serum electrolyte levels were normal. In addition, during her hospital stay and due to the high suspicion of Gitelman syndrome, a genetic study was performed, which reported a mutation of the SCL12A3 gene, confirming the diagnosis. Conclusion: The sequential approach to a patient with recurrent hypokalemia is very important to reach an accurate diagnosis among a wide range of differential diagnoses., A síndrome de Gitelman é um distúrbio tubular renal primário hereditário raro, caracterizado por hipocalemia, hipomagnesemia, alcalose metabólica, normocalcemia e hipocalciúria. A maioria dos pacientes tem um curso benigno. Se presentes, os sintomas incluem fadiga e fraqueza muscular (cãibras), como sintomas mais frequentes e histórico de múltiplas hospitalizações por hipocalemia. O tratamento é baseado em diuréticos poupadores de magnésio, potássio e / ou potássio. Relatamos um caso clínico da síndrome de Gitelman em um paciente de 23 anos que apresenta as características clínicas, laboratoriais e moleculares da doença, enfatizando seu diagnóstico e ações terapêuticas, denotando a importância de uma abordagem adequada para a paciente jovem com hipocalemia, usando um algoritmo de diagnóstico, proposto no final do artigo. É importante conhecer esses casos clínicos, pois amplia a visão geral da hipocalemia e permite fazer um mapa mental dos diferentes diagnósticos diferenciais e como chegar à etiologia e, portanto, ao respectivo tratamento.
- Published
- 2022
39. Seudohipoparatiroidismo asociado con síndrome de Gitelman
- Author
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Saavedra-López, Harold Felipe, Meléndez-Rhenals, Sugeich, Saavedra-López, Harold Felipe, and Meléndez-Rhenals, Sugeich
- Abstract
Introduction: Pseudohypoparathyroidism (PHP) is a genetic disease with a very low prevalence that causes parathyroid hormone (PTH) resistance, in which patients present complications secondary to the resulting hypocalcemia. Clinical case: A 37-year-old man with a history of tetanic seizures since childhood and an imprecise diagnosis of hypokalemic periodic paralysis since 2013 was admitted to the emergency department of a secondary care hospital in Bogotá D.C., Colombia, due to paresthesia in his hands and feet for two days, which worsened to painful intermittent muscle spasms. The patient stated that he had no genetic family history. Laboratory tests showed hypocalcemia, hypomagnesemia, hyperphosphatasemia, hypokalemia, and elevated PTH levels (369 pg/mL). Therefore, after ruling out several causes of secondary hyperparathyroidism, PTH-dependent hypocalcemia compatible with PHP was suspected. Simultaneously, the patient had compensated metabolic alkalosis, increased renal potassium loss, hypocalciuria, and normal blood pressure, raising the possibility of Gitelman syndrome (GS). Taking this into account, calcium, potassium and magnesium supplementation was started, achieving the complete resolution of the symptoms and normal electrolytes levels. However, it should be noted that since the hospital where the patient was treated did not have the necessary means to perform genetic tests, which is common in Colombia, it was not possible to confirm the diagnosis of both conditions. Conclusion: Although genetic confirmation of the PHP and GS diagnoses was not possible in this case, this would be the second case reported in the world of a patient with clinical suspicion of PHP and GS, which could be a new, yet unknown, genetic mutation that explains the simultaneous occurrence of these two conditions., Introducción. El seudohipoparatiroidismo (SPT) es una enfermedad genética con una prevalencia muy baja que causa resistencia a la paratohormona (PTH), con complicaciones subsecuentes a la hipocalcemia resultante. Presentación del caso. Hombre de 37 años con antecedente de crisis tetánicas desde la infancia y con diagnóstico impreciso de parálisis periódica hipocaliémica desde 2013 que ingresó al servicio de urgencias de un hospital de segundo nivel de Bogotá D.C., Colombia, por experimentar parestesias en manos y pies durante dos días, las cuales empeoraron a espasmos dolorosos intermitentes. El paciente negó antecedentes genéticos familiares. En los exámenes de laboratorio se reportó hipocalcemia, hipomagnesemia, hiperfosfatemia e hipocalemia, además de niveles elevados de PTH (369 pg/mL), por lo que, luego de descartarse varias causas de hiperparatiroidismo secundario, se sospechó hipocalcemia dependiente de PTH, compatible con SPT. Al mismo tiempo, el paciente presentó alcalosis metabólica, aumento de pérdidas renales de potasio, hipocalciura y presión arterial normal, por lo que se sospechó síndrome de Gitelman (SG). Teniendo en cuenta lo anterior, se inició suplementación de calcio, potasio y magnesio, obteniéndose una resolución completa de los síntomas y niveles normales de electrolitos. En todo caso, debe mencionarse que debido a que en el hospital no se contaba con los medios necesarios para realizar las pruebas genéticas, algo frecuente en Colombia, no fue posible confirmar el diagnóstico de estas dos condiciones. Conclusión. Si bien en este caso no fue posible obtener la confirmación genética del diagnóstico de SPT y SG, este sería el segundo caso reportado en el mundo de un paciente con sospecha clínica de SPT y SG, lo que podría constituir una nueva mutación genética aún desconocida que explique la ocurrencia simultánea de estas dos condiciones.
- Published
- 2022
40. Hipercortisolismo severo e hipocalemia recurrente
- Author
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Pinzón Tovar, A., Oviedo Cali, M., Jimenez Salazar, S., Mendez, H., Buitrago Toro, Kenny, Pinzón Tovar, A., Oviedo Cali, M., Jimenez Salazar, S., Mendez, H., and Buitrago Toro, Kenny
- Abstract
Endogenous Cushing syndrome derives from a chronic, inappropriate, and sustained increase in glucocorticoids, mainly in response to remarkably high serum concentrations of adrenocorticotropic hormone (ACTH) secreted from an adenohypophyseal tumor, Cushing's disease, or due to ectopic production by neuroendocrine tumors. Adrenal Cushing’s disease is caused by tumors of the adrenal cortex that autonomously produce cortisol and this is independent from ACTH action. Clinical course, treatment, prognosis, and possible complications depend on correctly identifying the triggering lesion; this situation frequently becomes a challenging experience for clinicians. We present the case of a 62-year-old woman, admitted for constitutional symptoms with severe hypokalemia that was difficult to correct and severe hypercortisolism., El síndrome de Cushing endógeno deriva de un aumento crónico, inapropiado y sostenido de glucocorticoides principalmente como respuesta al exceso en las concentraciones séricas elevadas de la hormona adrenocorticotropa (ACTH) desde un tumor adenohipofisiario, enfermedad de Cushing; o producida de forma ectópica por tumores neuroendocrinos. El Cushing suprarrenal se origina por tumores de la corteza adrenal que producen de forma autónoma cortisol y es independiente de ACTH. El curso clínico, tratamiento, pronóstico y posibles complicaciones dependen de identificar de forma correcta la lesión desencadenante; situación que en múltiples ocasiones resulta en una experiencia retadora para los clínicos. Se presenta el caso de una mujer de 62 años, ingresada por síntomas constitucionales con hipocaliemia severa de difícil corrección e hipercortisolismo severo.
- Published
- 2022
41. Símdrome de Gitelman, causa rara de hipopotasemia refractaria. Reporte de caso
- Author
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Zambrano-Urbano, Jose Leonel, Delgado-Truque, Andrés Emilson, Ocampo-Chaparro, José Mauricio, and Castro-Flórez, Ximena
- Subjects
Miembro 3 de la familia de transportadores de soluto 12 ,Síndrome de Gitelman ,Hipopotasemia ,Solute Carrier Family 12, Member 3 ,Hypokalemia ,Deficiencia de magnesio (DeCS) ,Magnesium Deficiency (MeSH) ,Gitelman Syndrome - Abstract
Introduction: Gitelman syndrome is a rare hereditary primary renal tubular disorder, with a prevalence of approximately 1 to 10 cases per 40 000 people. It does not have specific symptoms, so its diagnosis depends on high clinical suspicion by the treating physical and a sequential approach to hypokalemia, especially in young patients. Thus, a diagnostic algorithm is proposed at the end of this report. Case presentation: A 23-year-old woman with a history of hospitalization due to hypokalemia presented to the emergency service with intermittent cramping in her lower limbs, which was exacerbated by gastrointestinal symptoms. Laboratory tests reported the following findings: metabolic alkalosis, elevated levels of potassium, magnesium, chloride and sodium in urine, and reduced levels of calcium in urine. Thus, potassium supplementation and eplerenone administration were started, obtaining the complete resolution of symptoms. At her last follow-up appointment, the patient was asymptomatic, and her serum electrolyte levels were normal. In addition, during her hospital stay and due to the high suspicion of Gitelman syndrome, a genetic study was performed, which reported a mutation of the SCL12A3 gene, confirming the diagnosis. Conclusion: The sequential approach to a patient with recurrent hypokalemia is very important to reach an accurate diagnosis among a wide range of differential diagnoses. Resumen Introducción. El síndrome de Gitelman es un trastorno tubular renal primario hereditario poco frecuente, con una prevalencia aproximada de 1 a 10 casos por cada 40 000 personas; su sintomatologia es inespecífica, por lo que su diagnóstico depende de la alta sospecha clínica por parte del médico tratante y de un abordaje secuencial de la hipopotasemia, sobre todo en pacientes jóvenes, para lo cual se propone un algoritmo diagnóstico al final de este reporte. Presentación de caso. Mujer de 23 años con antecedente de hospitalización por hipopotasemia, quien consultó por calambres musculares intermitentes en miembros inferiores, los cuales se agudizaron debido a síntomas gastrointestinales. En los exámenes de laboratorio se reportaron los siguientes hallazgos: alcalosis metabólica, niveles elevados de potasio, magnesio, cloro y sodio en orina, y niveles reducidos de calcio en orina, por lo que se inició suplementación de potasio y manejo con eplerenona, obteniéndose resolución completa de los síntomas. En su último control, la paciente se encontraba asintomática y sus niveles séricos de electrolitos eran normales. Además, durante la hospitalización, y debido a la alta sospecha de síndrome de Gitelman, se solicitó estudio genético que reportó mutación del gen SCL12A3, confirmándose el diagnóstico. Conclusión. El abordaje secuencial de un paciente con hipopotasemia recurrente es de gran importancia para realizar un diagnóstico certero ante una amplia gama de diagnósticos diferenciales.
- Published
- 2022
42. Acidose tubular renal associada ao novo coronavírus: relato de caso
- Author
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Fagundes, Brunna Izabelle Alves de Oliveira Pereira, Leal, Natália Alencar, Leão, Sura Amélia Barbosa Félix, Fachin, Laercio Pol, Barbosa, Valtuir Félix, and Dantas, Thaís Teixeira
- Subjects
Acidose Tubular Renal ,Cuadriplejia ,Hipopotasemia ,Hypokalemia ,Hipopotassemia ,COVID-19 ,Quadriplegia ,Tubular Acidosis ,Acidosis Tubular - Abstract
A relate of a case of a young patient who presented a diagnosis of quadriplegia and evolved to a cardiorespiratory arrest due to their diagnosis of Distal Renal Tubular Acidosis concomitant with COVID-19.As a consequence of the patient’s serious case of hypokalemia, they needed mechanical ventilation and potassium replacement. It is noted that the infection by the new coronavirus can cause cytopathic harm, rendering the renal buffer system ineffective, and, if not treated properly, can lead to a bad prognosis. Se relata el caso de un paciente joven que presentóun diagnóstico de tetraplejia y evolucionó a un paro cardiorrespiratorio por su diagnóstico de Acidosis Tubular Renal Distal concomitante con COVID-19. Como consecuenciadel grave cuadro de hipopotasemiadel paciente, necesitóventilaciónmecánica y reposición de potasio. Se destaca que lainfección por elnuevocoronaviruspuede causar dañocitopático, volviendo ineficaz el sistema tampón renal y, si no se trata adecuadamente, puedeconducir a un mal pronóstico. Relata-se um caso de um paciente jovem que apresentou quadriplegia e evoluiu com parada cardiorrespiratória, devido ao diagnóstico de Acidose Tubular Renal Distal concomitante ao de COVID-19. Diante disso, em consequência da hipocalemia grave, necessitou de ventilação mecânica e reposição de potássio. Nota-se que a infecção pelo novo coronavírus pode ocasionar um dano citopático, tornando o sistema tampão renal ineficaz, e, se não tratado de forma adequada, pode levar a um mau prognóstico.
- Published
- 2022
43. [Atypical initial manifestation of primary hyperaldosteronism].
- Author
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Arnés-García D, Tornero-Divieso ML, and Rosales-Castillo A
- Subjects
- Humans, Hypokalemia etiology, Hyperaldosteronism complications, Hyperaldosteronism diagnosis, Hypertension complications, Rhabdomyolysis complications
- Abstract
Approximately 10% of cases of arterial hypertension are due to a secondary cause, being among the most frequent primary hyperaldosteronism, characterized by hypertension, metabolic alkalosis and hypokalemia. However, on rare occasions it can present in an atypical way, in the form of muscle weakness and myalgia secondary to rhabdomyolysis due to severe hypokalemia, as in the case described., (Copyright © 2023 SEH-LELHA. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
44. Mujer joven con diarrea crónica
- Author
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María Vares González, Lucía Ferreira González, Lucía Ramos Merino, and Concepción Guillén Blanco
- Subjects
Diarrea crónica ,Tumores neuroendocrinos ,Vipoma ,WDHA ,Hipopotasemia ,Medicine ,Internal medicine ,RC31-1245 - Abstract
La diarrea crónica es una entidad frecuente. Las causas son múltiples, por lo que llegar al diagnóstico definitivo puede resultar complejo acarreando con ello una demora diagnóstica que puede llegar a ser mortal. Se expone el caso de una mujer joven que desarrolla hipopotasemia severa secundaria a un VIPoma, tumor neuroendocrino secretor de péptido intestinal vasoactivo, hormona responsable del cuadro clínico: diarrea acuosa, hipopotasemia y aclorhidria. Chronic diarrhea is frequent. The causes are multiple, so reaching the definitive diagnosis can be complex. The diagnostic delay can be deadly. We describe the case of a young woman who developed severe hypokalemia secondary to VIPoma, neuroendocrine tumor secreting vasoactive intestinal peptide, a hormone responsible for the clinical: watery diarrhea, hypokalemia and achlorhydria
- Published
- 2013
- Full Text
- View/download PDF
45. Hypokalemic periodic paralysis. Presentation of a case
- Author
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Carlos García Gómez, Samuel Sánchez Sánchez, and Gretel Ruíz Martínez
- Subjects
Medicine (General) ,parálisis periódica hipopotasémica ,hipopotasemia ,R5-920 ,enfermedades neuromusculares ,Public aspects of medicine ,RA1-1270 ,debilidad muscular - Abstract
Hypokalemic periodic paralysis is generally caused by autosomal dominant mutations in the voltage-dependent calcium channel gene; seizures of weakness usually persist for hours or days before gradually resolving; the serum potassium level may be low or normal during the crisis. This disorder can present in an acquired way in conditions such as digestive losses of potassium, potassium-depleting diuretics, among others. The case of a 53-year-old white-skinned patient who came to the clinic due to loss of muscle strength in all four limbs, and preserved osteotendinous reflexes it is describe. In the tests, only the low serum potassium values (1.99 mmol / L) stand out. The rare frequency with which this disorder occurs, the form of presentation in this patient, and the probability of confusing it with other diseases, motivated the publication of the article.
- Published
- 2020
46. Parálisis periódica tirotóxica. Reporte de un caso
- Author
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Victor Vergara and Patricia Sobarzo
- Subjects
Medicine (General) ,hipopotasémia ,R5-920 ,tirotoxicosis ,parálisis ,hipertiroidismo - Abstract
La parálisis periódica tirotóxica (PPTH) esuna afección esporádica que se presenta con debilidad muscular recurrente y transitoria e hipocalemia severa en pacientes con tirotoxicosis, se presenta este caso ya que es una complicación muy rara del hipertiroidismo más aún cuando se presenta como debut de la enfermedad de Graves Basedow. El objetivo es presentar las características clínicas, tratamiento y la evolución de un paciente con parálisis tirotóxica. El paciente iniciósíntomas de la enfermedad de Graves Basedow, con una parálisis periódica hipopotasémica, que mejorórápidamente con la corrección del déficit de potasio (K+) por vía intravenosa. Se deben identificar correctamente las patologías que se presentan con debilidad de miembros superiores e inferiores, ya que fácilmente se pueden confundir con otras enfermedades que necesitan diagnóstico y tratamiento diferentes y más agresivos.
- Published
- 2020
- Full Text
- View/download PDF
47. MODIFICĂRILE POTASEMIEI ÎN SEPSIS LA SUGAR ŞI COPILUL MIC
- Author
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Oana-Roxana Ciobotaru, O. Ciobotaru, C. Paiu, Irina-Mihaela Ciomaga, and M. Burlea
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sepsis ,hipopotasemia ,electrocardiograma ,mortalitate ,Medicine ,Pediatrics ,RJ1-570 - Abstract
Obiectiv: Obiectivele acestui studiu au fost cercetarea unor corelaţii între potasemie şi rata mortalităţii, doza de potasiu administrată pe kilogram corp şi pe zi, valoarea pH-ului seric şi modifi cările electrocardiogramei, în sepsis, la sugar şi copilul mic. Material şi metodă: S-a efectuat un studiu retrospectiv pe un număr de 72 de copii (vârsta 1 lună - 7 ani), internaţi cu diagnosticul de sepsis în Secţia de Terapie Intensivă a Spitalului Clinic de Urgenţă „Sf. Maria“ Iaşi în perioada 2007-2009. A fost alcătuit un protocol de analiză a cazuisticii care să permită corelaţii în dinamică a valorilor potasemiei cu alţi parametrii clinici, biologici şi funcţionali. Rezultate: Pe parcursul internării, 48,6% din pacienţi au avut o potasemie normală, 56,9% hipopotasemie moderată, 37,5% kaliemie sub 2,5 mEq/l, 2% hiperpotasemie. Corelaţia Pearson între potasiu seric şi cantitatea de K+ mEq/kg corp/zi pentru întreg lotul studiat a fost - 0,37 (p=0,00), iar în grupul pacienţilor decedaţi, r = – 0,36, (p= 0,002). Pentru toţi pacienţii afl aţi în studiu între kaliemie şi pH-ul seric s-a obţinut un indice de corelaţie de 0,44 (p=0,00); pentru eşantionul pacienţilor decedaţi, r = 0,39, (p=0,015). Hipopotasemia moderată/ severă s-a reflectat prin subdenivelare de ST în 39,7% cazuri, aplatizarea undei T în 77,9% cazuri, iar prezenţa undei U în 72% cazuri. În acest lot nu s-au semnalat tulburări de ritm. Concluzii: Hipopotasemia a fost principala modifi care a kaliemiei la pacienţii cu sepsis dar, din punct de vedere statistic, valoarea serică a potasiului nu a infl uenţat rata mortalităţii. Nu s-a constatat o concordanţă între potasemie şi modifi cările electrocardiogramei.
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- 2010
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48. Infarto agudo de miocardio e hipopotasemia severa por consumo de regaliz durante el confinamiento por COVID-19
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A. Barrio-Rodriguez, V.E. Vallejo-Garcia, and M. Heras-Benito
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Pseudohyperaldosteronism ,Substance-Related Disorders ,Liquorice ,Myocardial Infarction ,Hypokalemia ,Pseudohiperaldosteronismo ,030204 cardiovascular system & hematology ,Pharmacology ,Severity of Illness Index ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Hipertensión ,Severity of illness ,Glycyrrhiza ,Internal Medicine ,Humans ,Medicine ,030212 general & internal medicine ,Myocardial infarction ,Glycyrrhizin ,Active metabolite ,Hypokalaemia ,Aged, 80 and over ,biology ,Regaliz ,business.industry ,COVID-19 ,Prodrug ,medicine.disease ,biology.organism_classification ,chemistry ,Hipopotasemia ,Hypertension ,Quarantine ,Glycyrrhetinic Acid ,Female ,Caso Clínico ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Infarto - Abstract
El regaliz es una es una de las hierbas con propiedades medicinales más antiguas que se conocen y consta de hasta 300 compuestos activos. Se utiliza desde hace milenios por sus propiedades digestivas, antiinflamatorias y antiinfecciosas, pero sus posibles efectos tóxicos fueron descritos hace pocos años y hay creciente interés en los efectos secundarios asociados a su consumo crónico. El principal componente activo del regaliz es el profármaco glicirricina y su metabolito activo, el ácido glicirrético, y es una causa infrecuente de hipopotasemia por supresión del eje renina-angiotensina-aldosterona, que causa pseudohiperaldostenonismo. Describimos un caso inusual de infarto agudo de miocardio secundario en paciente con consumo crónico de regaliz.
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- 2021
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49. A case report of Gitelman syndrome resulting from two novel mutations in SLC12A3 gene.
- Author
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Wolyniec, Wojciech, Kaniuka-Jakubowska, Sonia, Nagel, Mato, Wolyniec, Zuzanna, Obolonczyk, Lukasz, Swiatkowska-Stodulska, Renata, Sworczak, Krzysztof, and Renke, Marcin
- Abstract
Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2016
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50. Gitelman syndrome, a rare cause of refractory hypokalemia. A case repor
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Zambrano-Urbano, Jose Leonel, Delgado-Truque, Andrés Emilson, Ocampo-Chaparro, José Mauricio, Castro-Flórez, Ximena, Zambrano-Urbano, Jose Leonel, Delgado-Truque, Andrés Emilson, Ocampo-Chaparro, José Mauricio, and Castro-Flórez, Ximena
- Abstract
Introduction: Gitelman syndrome is a rare hereditary primary renal tubular disorder, with a prevalence of approximately 1 to 10 cases per 40 000 people. It does not have specific symptoms, so its diagnosis depends on high clinical suspicion by the treating physical and a sequential approach to hypokalemia, especially in young patients. Thus, a diagnostic algorithm is proposed at the end of this report. Case presentation: A 23-year-old woman with a history of hospitalization due to hypokalemia presented to the emergency service with intermittent cramping in her lower limbs, which was exacerbated by gastrointestinal symptoms. Laboratory tests reported the following findings: metabolic alkalosis, elevated levels of potassium, magnesium, chloride and sodium in urine, and reduced levels of calcium in urine. Thus, potassium supplementation and eplerenone administration were started, obtaining the complete resolution of symptoms. At her last follow-up appointment, the patient was asymptomatic, and her serum electrolyte levels were normal. In addition, during her hospital stay and due to the high suspicion of Gitelman syndrome, a genetic study was performed, which reported a mutation of the SCL12A3 gene, confirming the diagnosis. Conclusion: The sequential approach to a patient with recurrent hypokalemia is very important to reach an accurate diagnosis among a wide range of differential diagnoses., Introducción. El síndrome de Gitelman es un trastorno tubular renal primario hereditario poco frecuente, con una prevalencia aproximada de 1 a 10 casos por cada 40 000 personas; su sintomatología es inespecífica, por lo que su diagnóstico depende de la alta sospecha clínica por parte del médico tratante y de un abordaje secuencial de la hipopotasemia, sobre todo en pacientes jóvenes, para lo cual se propone un algoritmo diagnóstico al final de este reporte. Presentación de caso. Mujer de 23 años con antecedente de hospitalización por hipopotasemia, quien consultó por calambres musculares intermitentes en miembros inferiores, los cuales se agudizaron debido a síntomas gastrointestinales. En los exámenes de laboratorio se reportaron los siguientes hallazgos: alcalosis metabólica, niveles elevados de potasio, magnesio, cloro y sodio en orina, y niveles reducidos de calcio en orina, por lo que se inició suplementación de potasio y manejo con eplerenona, obteniéndose resolución completa de los síntomas. En su último control, la paciente se encontraba asintomática y sus niveles séricos de electrolitos eran normales. Además, durante la hospitalización, y debido a la alta sospecha de síndrome de Gitelman, se solicitó estudio genético que reportó mutación del gen SCL12A3, confirmándose el diagnóstico. Conclusión. El abordaje secuencial de un paciente con hipopotasemia recurrente es de gran importancia para realizar un diagnóstico certero ante una amplia gama de diagnósticos diferenciales., A síndrome de Gitelman é um distúrbio tubular renal primário hereditário raro, caracterizado por hipocalemia, hipomagnesemia, alcalose metabólica, normocalcemia e hipocalciúria. A maioria dos pacientes tem um curso benigno. Se presentes, os sintomas incluem fadiga e fraqueza muscular (cãibras), como sintomas mais frequentes e histórico de múltiplas hospitalizações por hipocalemia. O tratamento é baseado em diuréticos poupadores de magnésio, potássio e / ou potássio. Relatamos um caso clínico da síndrome de Gitelman em um paciente de 23 anos que apresenta as características clínicas, laboratoriais e moleculares da doença, enfatizando seu diagnóstico e ações terapêuticas, denotando a importância de uma abordagem adequada para a paciente jovem com hipocalemia, usando um algoritmo de diagnóstico, proposto no final do artigo.É importante conhecer esses casos clínicos, pois amplia a visão geral da hipocalemia e permite fazer um mapa mental dos diferentes diagnósticos diferenciais e como chegar à etiologia e, portanto, ao respectivo tratamento.
- Published
- 2021
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