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Submitted by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2022-03-03T19:24:44Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ITEM INDISPON??VEL - Solicite c??pia.pdf: 84143 bytes, checksum: bec574cfc2dc76cf8ba0e289d73276b9 (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2022-03-03T19:52:42Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ITEM INDISPON??VEL - Solicite c??pia.pdf: 84143 bytes, checksum: bec574cfc2dc76cf8ba0e289d73276b9 (MD5) Made available in DSpace on 2022-03-03T19:52:42Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ITEM INDISPON??VEL - Solicite c??pia.pdf: 84143 bytes, checksum: bec574cfc2dc76cf8ba0e289d73276b9 (MD5) Previous issue date: 2021-12-21 Objective: to build a nursing protocol that supports nurses' practices in the care of elderly hypertensive individuals within the Amazon context. Method: methodological study with a qualitative approach. The methodological course of this project will consist of 3 stages: in the first stage, the theoretical-scientific basis will be built from the development of an integrative literature review on nursing practices at aimed elderly hypertensive patients in the context of specialized care; in the second stage, systematic observation will be carried out through interviews with professional nurses who work in the specialized care network for the elderly in the city of Manaus, Amazonas; in the third stage, the construction and production of the nursing protocol will be carried out based on the first and second stages. Results: Manuscript presenting theoretical and scientific references, in addition to the contribution of professionals determining the domains as a basis for building the prototype of the protocol. These stages subsidized the technological product to contribute and assist in the professional practice of nurses within the specialized service, helping them to improve the quality of nursing care and decision-making with a view to resolving the provision of care in specialized care. Discussion: It is confirmed that the final product will contribute so that Amazonian and gerontological nursing in the state of Amazonas can be recognized for their best practices, as well as for contributing to the improvement of therapeutic adherence of the elderly person assisted in Specialized Care Centers In Manaus. Conclusion: The technological product is merged as a health assessment instrument and allowed a plurality of information considered essential within the Amazon context, enabling the visualization of actions employed in practices as priorities, which will guide-making and intervention of nursing. The need to deepen this theme is considered, as there are few published works relating to specialized nursing consultations within this context. Objetivo: Elaborar um protocolo de enfermagem como proposta de cuidado para a pessoa idosa com hipertens??o na aten????o especializada no contexto amaz??nico. M??todo: Estudo metodol??gico, que utilizou dados qualitativos, sendo desenvolvida em 3 etapas. Na 1 etapa: foi realizado estudo de revis??o integrativa com o objetivo de sintetizar o conhecimento, referente ??s produ????es cient??ficas sobre os protocolos de enfermagem para a assist??ncia e cuidado na aten????o especializada. Na 2 etapa: foi realizado uma pesquisa descrita, por interm??dio de uma entrevista semiestrurturada com os enfermeiros dos CAIMI???s. Cabe ressaltar que a an??lise dos dados ocorreu por processo de produ????o e an??lise dos dados com o uso IRAMUTEQ que possibilitou uma an??lise lexical para o tratamento do conte??do fornecido pelos participantes, o Corpus passou a ser composto por 5 Classes, e para cada uma delas foi computada e atribu??da uma lista de palavras maissignificativas que astraduzem. Na etapa 3: foi realizado a confec????o do prot??tipo, pautou-se no levantamento das melhores evid??ncias. Cabe ressaltar que esta etapa foi desenvolvida tendo como suporte das etapas 1 e 2, nesta fase contamos com o suporte da designer para melhor apresenta????o do prot??tipo. Resultados: Como produto das etapas da pesquisa apresentada temos na etapa1 a elabora????o de um manuscrito. Na etapa 2, a garantia do conhecimento dos profissionais assistenciais quanto ??s etapas para serem seguidas no protocolo a partir da an??lise dos dados, onde emergiram de 312 segmentos de texto (ST 76,10%), organizadas em 04 dom??nios que balizaram e foram fundamentais para a realiza????o da etapa 3. Sendo na etapa 3 o protocolo apresentado sistematizado na ??ntegra com 61 p??ginas disposto no Ap??ndice D. Conclus??o: Pondera-se que a tecnologia elaborada possa subsidiar os enfermeiros na pr??tica, potencializando o cuidado a pessoa idosa com hipertens??o na rede especializada. Al??m de contribuir para o avan??o das melhores pr??ticas de enfermagem gerontol??gica no contexto amaz??nico.

Submitted by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2021-09-01T02:02:30Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ITEM INDISPON??VEL - Solicite c??pia.pdf: 84143 bytes, checksum: bec574cfc2dc76cf8ba0e289d73276b9 (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2021-09-01T02:03:36Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ITEM INDISPON??VEL - Solicite c??pia.pdf: 84143 bytes, checksum: bec574cfc2dc76cf8ba0e289d73276b9 (MD5) Made available in DSpace on 2021-09-01T02:03:36Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ITEM INDISPON??VEL - Solicite c??pia.pdf: 84143 bytes, checksum: bec574cfc2dc76cf8ba0e289d73276b9 (MD5) Previous issue date: 2021-06-24 Introduction: To better meet the care demands of the sick person, nursing professionals need to constantly improve their technical skills and affective skills. The adoption of a healthy lifestyle, inside and outside the work environment, are important conditions to avoid the development of chronic diseases. General Objective: To verify the association of hypertension with lifestyle, presence of common mental disorder in nursing professionals. Methods: A descriptive, cross-sectional association study with nursing professionals who worked in two public hospitals in the city of Manaus. The data collection period was carried out from January to March 2020 in the first unit and in the second unit from January to July 2020. The sample was representative, considering the shift and professional category involved. Data collection consisted of the application of an instrument composed of sociodemographic variables and personal and family history of cardiovascular health and validated questionnaires called: "International Physical Activity Questionnaire - IPAQ" to verify the level of physical activity, "Alcohol Use Disorders Identification Test - AUDIT ??? to assess alcohol consumption; and ???Self ??? Reporting Questionnaire 20??? for common mental disorder screening. In addition, a casual measurement of systemic blood pressure was performed in order to obtain the prevalence of high blood pressure and/or self-reported hypertension, as well as its relationship with the other variables investigated in the group of professionals. Data were tabulated in the excel 2016 program and the analysis performed using descriptive and inferential statistics. A 95% confidence interval was adopted as a measure of precision to identify variables considered to be a risk or protective factor for hypertension. Results: the prevalence of hypertension among 394 nursing professionals was 22.8%. Among the variables associated with hypertension, the following stand out: age [OR=1.08 (95% CI 1.05-1.12); p

Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2020-05-09T02:45:39Z No. of bitstreams: 1 WashingtonLuizMarianodaSilvaDissertacao2020.pdf: 2237444 bytes, checksum: 78cb64a843f4664c7006ad3247c7938b (MD5) Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2020-05-09T02:46:10Z (GMT) No. of bitstreams: 1 WashingtonLuizMarianodaSilvaDissertacao2020.pdf: 2237444 bytes, checksum: 78cb64a843f4664c7006ad3247c7938b (MD5) Made available in DSpace on 2020-05-09T02:46:11Z (GMT). No. of bitstreams: 1 WashingtonLuizMarianodaSilvaDissertacao2020.pdf: 2237444 bytes, checksum: 78cb64a843f4664c7006ad3247c7938b (MD5) Previous issue date: 2020-03-03 The aim of this study was to verify the cardiovascular responses of elderly hypertensive patients submitted to different models of exercise sessions and the post-exercise hypotension phenomenon. Eighteen hypertensive elderly women, 69.4 ?? 6.9 years, 62.8 ?? 6.7 kg body weight, 125 ?? 14.1 mm Hg of systolic blood pressure (SBP) and 76 ?? 10 mm Hg of diastolic blood pressure (DBP) were submitted to five sessions: i) isometric handgrip (IHG); ii) isometric leg press (ILP); iii) treadmill (EST); iv) MIS of the sessions (MIS); v) control (CTL) without exercise. The isometric exercise sessions, IHG and ILP, were performed at 50% of the maximum voluntary isometric contraction (CVIM), 12 series of 1 'of contraction and 2' of pause between the series. The EST session was performed at 70% of the maximum heart rate, 12 series of 1 'walk and 2' pause. The MIS session consisted of 4 sets of each session (IHG + ILP + EST) with 1 'of exercise and 2' of interval between sets, totaling 12 minutes of exercise. A hydraulic handgrip dynamometer (Jamar, Sammons Preston, Illinois, USA), a load cell load (DinPro, CEFISE, Campinas, SP) was used to determine the CVIM at the IHG and ILP, respectively. Blood pressure (BP) and heart rate (HR) were measured using the oscillometric method on the Microlife?? device, model BP 3AC1-1 (Switzerland) at rest and in recovery at 30 and 60 min post-exercise. The double product (DP) was calculated using the product FC x systolic PA (SBP). Pulse pressure (PP) was determined by SBP - diastolic BP (DBP). There was a reduction in HR in relation to rest (p 0.05). The study demonstrated that in all IHG, ILP, EST and MIS exercise sessions, they induced a significant drop in HR and post-exercise PD in hypertensive elderly women. However, post-exercise we observe significant increases in SBP in the MIS session, and DBP in the IHG session. O objetivo deste estudo foi verificar as respostas cardiovasculares de pacientes idosas hipertensas submetidos a diferentes modelos de sess??es de exerc??cio e o fen??meno hipotens??o p??s-exerc??cios. Dezoito idosas hipertensas, 69,4??6,9 anos, 62,8??6,7 kg peso corporal, 125 ?? 14,1mm Hg de press??o arterial sist??lica (PAS) e 76 ?? 10 mm Hg de press??o arterial diast??lica (PAD) foram submetidas a cinco sess??es: i) isom??trico handgrip (IHG); ii) isom??trico leg press (ILP); iii) esteira (EST); iv) MIS das sess??es (MIS); v) controle (CTL) sem exerc??cio. As sess??es de exerc??cio isom??trico, IHG e ILP, foram realizadas a 50% da contra????o volunt??ria isom??trica m??xima (CVIM), 12 s??ries de 1??? de contra????o e 2??? de pausa entre as s??ries. A sess??o de EST foi realizada a 70% da frequ??ncia card??aca m??xima, 12 s??ries de 1??? de caminhada e 2??? de pausa. A sess??o MIS foi composta por 4 s??ries de cada sess??o (IHG+ILP+EST) com1??? de exerc??cio e 2??? de intervalo entre as s??ries, totalizando 12 minutos de exerc??cio. Foi utilizado um dinam??metro de preens??o palmar hidr??ulico (Jamar, Sammons Preston, Illinois, EUA), uma carga de c??lula de for??a (DinPro, CEFISE, Campinas, SP) para determinar a CVIM no IHG e ILP, respectivamente. A press??o arterial (PA) e a frequ??ncia card??aca (FC) foram mensuradas pelo m??todo oscilom??trico no aparelho da marca Microlife??, modelo BP 3AC1-1 (Su????a) em repouso e na recupera????o aos 30 e 60 min p??s-exerc??cio. O duplo produto (DP) foi calculado pelo produto FC x PA sist??lica (PAS). A press??o de pulso (PP) foi determinada por PAS ??? PA diast??lica (PAD). Houve uma redu????o da FC em rela????o ao repouso (p < 0,05) em todas as sess??es aos 30 e 60 min p??s-exerc??cio. A PAS aumentou aos 30 e 60 minutos p??s-exerc??cio na sess??o MIS (p< 0,05). A PAD aumentou aos 60 min p??s-exerc??cio nas sess??es IHG e MIS. O DP foi menor aos 30 e 60 min. p??s-exerc??cio na sess??o controle. N??o houve diferen??a para as demais vari??veis (p > 0,05). O estudo demonstrou que em todas as sess??es de exerc??cios IHG, ILP, EST e a MIS induziram uma queda significativa na FC e no DP p??s-exerc??cios em idosas hipertensas. No entanto, p??s-exerc??cio observarmos aumentos significativos da PAS na sess??o MIS, e da PAD na sess??o de IHG.

Submitted by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2019-10-09T19:31:20Z No. of bitstreams: 2 Reprodu????o N??o Autorizada.pdf: 47716 bytes, checksum: 0353d988c60b584cfc9978721c498a11 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2019-10-09T20:12:10Z (GMT) No. of bitstreams: 2 Reprodu????o N??o Autorizada.pdf: 47716 bytes, checksum: 0353d988c60b584cfc9978721c498a11 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Made available in DSpace on 2019-10-09T20:12:10Z (GMT). No. of bitstreams: 2 Reprodu????o N??o Autorizada.pdf: 47716 bytes, checksum: 0353d988c60b584cfc9978721c498a11 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2019-07-31 CNPq - Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico CAPES - Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior 92 99290-7681 Introduction: All cardiovascular diseases are the leading cause of death in Brazil and worldwide. The few biomedical studies performed with indigenous village groups reveal that obesity, arterial hypertension and diabetes mellitus are the main risk factors for the development of cardiovascular diseases. However, there are ethnic groups that have not yet been investigated for these risk factors. The present study is part of a universal project titled "Risk Factors for Cardiovascular Diseases in Indigenous Munduruku". Objectives: To compare the cardiovascular risk factors, with emphasis on arterial hypertension, of the Munduruku natives living in the villages of Kwat??, Fronteira, Laranjal and Mucaj??. Specific: Describe the anthropometric, metabolic and pressure variables, with emphasis on arterial hypertension; to describe the socioeconomic characteristics, lifestyle, habits, personal and family history and to identify the possible factor of association of these variables with hypertension. Methodology: Cross-sectional study of a quantitative approach, representative of the ethnic group involved. The study was conducted with 459 indigenous people, aged 18 from the Munduruku ethnic group living in Amazonas, Brazil. An interview was conducted that addressed all the variables of the research. Blood pressure was measured in three measurements and the mean of the last two measurements was used. Physical examination included the following data: weight, height, waist and neck circumference, bioimpedance and capillary measurement of glucose, triglycerides and cholesterol. The analyzes were carried out using software R 3.5.1. The variables were analyzed using a multinomial regression model, the odds ratios with the respective 95% confidence intervals and p - value were presented. The final multiple model revealed the factors associated with hypertension. Results: The prevalence of hypertension was 7.4%. After the adjusted analysis, the variables presented as risk factors were gender, age and waist circumference. The final multiple model revealed that men are 8 times more likely to have prehypertension than women; age showed that with every 1 year increase in age, there is a 10% increase in the chance of hypertension; and people with increased waist circumference are 4 times more likely to have hypertension than those with an adequate waist. Conclusion: Despite the low prevalence of hypertension in the non-indigenous population, the risk factors associated with hypertension that were presented reveal that changes in lifestyle and habits may contribute to the onset of these risk factors and increase the risk of hypertension. cardiovascular diseases among the Munduruku Indians. Therefore, health policies should be directed to indigenous peoples in a way that meets their particularities. Introdu????o: O conjunto das doen??as cardiovasculares representa a primeira causa de morte no Brasil e no mundo. Os poucos estudos biom??dicos realizados com grupos ind??genas aldeados revelam que obesidade, hipertens??o arterial e diabetes melitus s??o os principais fatores de risco para o desenvolvimento das doen??as cardiovasculares. Contudo, h?? grupos ??tnicos que ainda n??o foram investigados quanto a esses fatores de risco. O presente estudo faz parte de um projeto universal intitulado ???Fatores de Risco para Doen??as Cardiovasculares em Ind??genas Munduruku???. Objetivos: Comparar os fatores de risco cardiovascular, com ??nfase na hipertens??o arterial, dos ind??genas Munduruku que vivem nas aldeias de: Kwat??, Fronteira, Laranjal e Mucaj??. Espec??ficos: Descrever as vari??veis antropom??tricas, metab??licas e press??ricas, com ??nfase na hipertens??o arterial; descrever as caracter??sticas socioecon??micas, estilo de vida, h??bitos, antecedentes pessoais e familiares e identificar o poss??vel fator de associa????o dessas vari??veis com a hipertens??o. Metodologia: Estudo transversal de abordagem quantitativa, representativo do grupo ??tnico envolvido. O estudo foi realizado com 459 ind??genas, com idade a partir de 18 da etnia Munduruku que vivem no Amazonas, Brasil. Foi realizada uma entrevista que abordava todas as vari??veis da pesquisa. A press??o arterial foi aferida em tr??s medi????es e foi utilizada a m??dia das duas ??ltimas medi????es. O exame f??sico incluiu os seguintes dados: peso, altura, cincunfer??ncia do pesco??o e da cintura, bioimped??ncia e medi????o capilar de glicose, triglic??rides e colesterol. As an??lises foram feitas com aux??lio do software R 3.5.1. As vari??veis foram analisadas com o uso de um modelo de regress??o multinomial, foram apresentadas as raz??es de chance com os respectivos intervalos de confian??a de 95% e valor - p. O modelo m??ltiplo final revelou os fatores associados ?? hipertens??o. Resultados: A preval??ncia de hipertens??o foi de 7,4%. Ap??s a an??lise ajustada as vari??veis que se apresentaram como fator de risco foram sexo, idade e circunfer??ncia da cintura. O modelo m??ltiplo final revelou que os homens tem 8 vezes a chance de apresentar pr??-hipertens??o em rela????o ??s mulheres; a idade mostrou que a cada aumento em 1 ano na idade, h?? um aumento de 10% na chance de hipertens??o; e pessoas com circunfer??ncia da cintura aumentada tem 4 vezes a chance de hipertens??o em rela????o ??quelas com cintura adequada. Conclus??o: Apesar da preval??ncia baixa de hipertens??o em rela????o a popula????o n??o ind??gena, os fatores de risco associados ?? hipertens??o que foram apresentados revelam que as mudan??as nos h??bitos e no estilo de vida podem contribuir com o aparecimento desses fatores de risco e aumentar o risco de doen??as cardiovasculares entre os ind??genas Munduruku. Portanto, as pol??ticas de sa??de devem ser direcionadas aos povos ind??genas de forma que atenda ??s suas particularidades.

Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2019-06-04T12:55:58Z No. of bitstreams: 1 RafaeldosReisVieiraOlherTese2019.pdf: 5043640 bytes, checksum: 21a726174c04b397bdea8c6c6d7051a7 (MD5) Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2019-06-04T12:56:30Z (GMT) No. of bitstreams: 1 RafaeldosReisVieiraOlherTese2019.pdf: 5043640 bytes, checksum: 21a726174c04b397bdea8c6c6d7051a7 (MD5) Made available in DSpace on 2019-06-04T12:56:30Z (GMT). No. of bitstreams: 1 RafaeldosReisVieiraOlherTese2019.pdf: 5043640 bytes, checksum: 21a726174c04b397bdea8c6c6d7051a7 (MD5) Previous issue date: 2019-02-22 Hypertension is known to be one of the major risk factors for cardiovascular diseases in the world. On the other hand, recent scientific evidence suggests that isometric strength exercise (ISE) could be part of antihypertensive treatment. However, little is known regarding acute cardiovascular responses involving large muscle mass and the possible mechanisms involved in post-isometric exercise hypotension (PIEH) in hypertensive adults. The Nitric oxide (NO-) and oxidative stress (OE) may be important elements involved in the pathophysiology of hypertension. The aim of this study was to investigate the hemodynamic, oxidative stress and plasma concentrations of nitric oxide responses to a submaximal isometric exercise involving large muscle mass in leg press 45?? (LP45) and bench press (BP) equipment. Fourteen hypertensive (HT???7-???, 7-???)age: 35.9 ?? 8.1 years, height: 1.73 ?? 0.10 m, body mass: 78.0 ?? 15.8 kg, systolic blood pressure (SBP): 128.89 ?? 11.95, diastolic blood pressure (DBP) 82.96 ?? 5.08 and 10 normotensive (NT???5-???, 5-???): age: 41.1 ?? 9.4 years, height: 1.71 ?? 0.12 m, body mass: 82.3 ?? 22.4 kg, SBP: 115 ?? 1.65, DBP: 71.75 ?? 6.51 individuals were submitted to two experimental sessions in the LP45 and BP, being: i) control session (without exercise) and ii) experimental session (SEI) with 8 sets x 1-min contraction at 30% maximal voluntary isometric contraction (MVIC) with 2-min rest interval, the sessions were carried out in randomized order. Blood Pressure (BP) was measured rest and during 60-min post-exercise. Blood samples were collected at rest, immediately after the session and 60-min post-exercise. The NO- was obtained through the Griess reaction method. The OS parameters were analyzed using commercial kits. A repeated-measures ANOVA with Bonferroni???s post-hoc was used to analyze all dependent variables. A significant decrease post-exercise in systolic BP was observed only for HT at 45-min (p=0.003, ??%=4.44%) and 60-min (p=0.018, ??%=5.58%) in relation to rest. No significant differences were obtained for NT. With respect to NO- both groups increased the Bioavailability immediately post-exercise. Regarding OS parameters, the analysis of thiobarbituric acid reactive substances (TBARS) presented a significant reduction in relation to the rest at 60-min post-isometric exercise in both groups. Whereas the catalase activity increased in both groups immediately post-exercise, remaining increased after 60-minpost exercise. We can conclude that submaximal isometric exercise with large muscle mass involved promotes an increase in pro-oxidant activity leading to an increase in NO-bioavailability, an increase in antioxidant activity and consequently decrease in pressure levels in hypertensive adults. A Hipertens??o Arterial Sist??mica (HAS) ?? um dos maiores fatores de risco para doen??as cardiovasculares no mundo. Por outro lado, recentes evid??ncias cient??ficas sugerem que o exerc??cio isom??trico (EI) pode ser um importante aliado no tratamento anti-hipertensivo. Entretanto, pouco se sabe sobre as respostas cardiovasculares agudas envolvendo grandes massas musculares e os poss??veis mecanismos envolvidos na hipotens??o p??s-exerc??cio isom??tricos (HPEI) em adultos hipertensos. O ??xido n??trico (NO-) e o estresse oxidativo (EO) podem ser importantes elementos envolvidos na fisiopatologia da hipertens??o. O objetivo desse estudo foi investigar as respostas hemodin??micas, o estresse oxidativo e as concentra????es plasm??ticas de NO- a uma sess??o subm??xima de EI envolvendo uma maior quantidade de massa muscular nos equipamentos legpress 45?? (LP45) e banco supino (SUP). Foram recrutados14 pacientes hipertensos (HT???7-???, 7-???): idade: 35,9 ?? 8,1 anos, estatura: 1,73 ?? 0,10 m, massa corporal total: 78,0 ?? 15,8 kg, press??o arterial sist??lica (PAS): 128,89 ?? 11,95, press??o arterial diast??lica (PAD) 82,96 ?? 5,08, e 10 normotensos (NT???5-???, 5-???): idade: 41,1 ?? 9,4 anos, estatura: 1,71 ?? 0,12 m, massa corporal total: 82,3 ?? 22,4 kg, PAS: 115 ?? 1,65, PAD: 71,75 ?? 6,51. Os participantes foram submetidos a duas sess??es nos aparelhosLP45 e SUP, sendo 1??) sess??o controle (sem exerc??cio) e 2??) sess??o experimental composta por8 s??ries de 1-min de contra????o a 30% da contra????o volunt??ria isom??trica m??xima (CVIM) com 2-min de intervalo de recupera????o, as sess??es foram realizadas de forma aleatorizada. A PA foi mensurada em repouso e durante 60-min p??s-exerc??cio. Amostras de sangue foram coletadas em repouso, imediatamente ap??s e 60-min p??s-exerc??cio. O NO- foi obtido por meio do m??todo de rea????o de Griess. Os par??metros do EO foram analisados utilizando kits comerciais. Uma ANOVA de medidas repetidas com post-hoc de Bonferroni foi utilizada para as an??lises estat??sticas de todas as vari??veis dependentes. Houve uma significante redu????o p??s exerc??cio na PAS observada no grupo HT, nos momentos 45-min (p=0,03, ??%=4,44%) e 60-min (p=0,018, ??%=5,58%) em rela????o ao repouso. N??o houve diferen??a significativa para o grupo NT. Com rela????o ao NO- ambos os grupos apresentaram aumento significativo na biodisponibilidade imediatamente p??s exerc??cio. Em rela????o aos par??metros de EO as an??lises de subst??ncias reativas ao ??cido tiobarbit??rico (TBARS) apresentaram uma diminui????o significativa em rela????o ao repouso aos 60-min p??s-exerc??cio isom??trico em ambos os grupos. Enquanto que a atividade da catalase aumentou em ambos os grupos imediatamente p??s-exerc??cio, permanecendo elevada 60-min p??s exerc??cio. Podemos concluir que exerc??cio isom??trico subm??ximo envolvendo grande massa muscular promove aumento na atividade pr??-oxidante, levando ao aumento na biodisponibilidade de NO-, aumento da atividade antioxidante e consequentemente diminui????o dos n??veis press??ricos em adultos hipertensos.

Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2019-05-17T14:52:59Z No. of bitstreams: 1 DahandaCunhaNascimentoTese2018.pdf: 3512622 bytes, checksum: 79da5438d7933215f1ff83fb3432167c (MD5) Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2019-05-17T14:53:09Z (GMT) No. of bitstreams: 1 DahandaCunhaNascimentoTese2018.pdf: 3512622 bytes, checksum: 79da5438d7933215f1ff83fb3432167c (MD5) Made available in DSpace on 2019-05-17T14:53:09Z (GMT). No. of bitstreams: 1 DahandaCunhaNascimentoTese2018.pdf: 3512622 bytes, checksum: 79da5438d7933215f1ff83fb3432167c (MD5) Previous issue date: 2018-11-26 Hypertension is a prevalent disease in older adults and is associated with increased incidence of coronary artery disease, stroke, and heart failure events. Despite the beneficial effects of resistance training (RT) for the prevention and reduction of blood pressure (BP), reductions in systolic blood pressure (SBP) will occur for subjects who show exceptionally large responses to training when compared with individuals who show small responses to training. Thus, the purpose of the present study was to identify the variability of BP response to 10- week RT program in hypertensive and normotensive elderly women. The second aim of this study was to present statistical procedures for a better data interpretation of responsiveness, explain how to deal with regression to the mean effect (RTM), and describe how to determine clinically important changes in BP from significant real difference (SRD). Twenty-seven untrained hypertensive (age = 68,37 ?? 5,55 years; height = 1,55 ?? 0,05 m; BMI = 27,94 ?? 3,65 kg/m??) and 12 normotensive women (age = 70,00 ?? 7,41 years; height = 1,56 ?? 0,06 m; BMI = 27,34 ?? 5,20 kg/m??) participated in the present study. The RT consisted of a periodized linear model. The exercises performed were: machine leg press, machine chest press, machine leg extension, machine low row, and machine leg curl. The number of repetitions were reduced (maintaining the minimal zone established for each cycle) as the intensity increased. The responsiveness of resting SBP was determined based on the percent decline between the pre- and post-training time points or mesocycles T1 and T4. The term responders was used to describe subjects who exhibited a percent SBP decline ??? -2.58% and the term non-responders for subjects who exhibited a percent SBP decline < -2.58%, respectively. Both the responders and nonresponders in the hypertensive group presented significant changes in SBP (- 7.83 ?? 5.70 mmHg vs. 3.78 ?? 7.42 mmHg), respectively. Moreover, the responders and non-responders in the normotensive group presented significant changes in SBP as well (-8.58 ?? 5.52 mmHg vs. 5.71 ?? 3.84 mmHg). Furthermore, statistical analyses were performed using One-Way Repeated Measures ANOVA, an analysis of covariance (ANCOVA), linear mixed model (LMM), and SRD was also calculated. The results confirmed that initial SBP was the more powerful predictor of post-exercise SBP response, as analyzed by the ANCOVA and LMM. In conclusion, SBP presents a heterogeneous response to a controlled RT program in hypertensive and normotensive elderly women. For the second aim of this study, the importance of incorporating SRD and RTM analysis to determine what should be clinically important from what is known as the error of measurement and to provide a better interpretation of the results was confirmed. A hipertens??o arterial ?? uma doen??a prevalente em idosos e est?? associada com o aumento da incid??ncia de doen??a arterial coronariana, acidente vascular encef??lico e insufici??ncia card??aca. O treinamento de for??a (TF) ?? recomendado como forma de interven????o para a preven????o e redu????o da press??o arterial (PA) e apesar dos efeitos ben??ficos, redu????es na press??o arterial sist??lica (PAS) ocorrer??o para indiv??duos que apresentam respostas excepcionalmente elevadas ao treinamento, quando comparados com indiv??duos que apresentam respostas reduzidas ao treinamento. Com isso, o objetivo do presente estudo foi avaliar o efeito do TF sobre a PA e sua variabilidade ap??s 10 semanas de treinamento em mulheres idosas hipertensas e normotensas. Al??m disso, o segundo objetivo do estudo foi apresentar procedimentos estat??sticos para uma melhor interpreta????o dos dados sobre a responsividade, explicar como lidar com o efeito da regress??o a m??dia (RM) e descrever como determinar altera????es clinicamente importantes na PA pelo c??lculo da diferen??a cl??nica real (DR). Vinte e sete mulheres idosas hipertensas (idade = 68,37 ?? 5,55 anos; = estatura = 1,55 ?? 0,05 m; IMC = 27,94 ?? 3,65 kg/m??) e 12 mulheres idosas normotensas (idade = 70,00 ?? 7,41 anos; estatura = 1,56 ?? 0,06 m; IMC = 27,34 ?? 5,20 kg/m??) sem experi??ncia no TF participaram do estudo. O TF seguiu o modelo de periodiza????o linear e os exerc??cios realizados foram: leg press, supino m??quina, cadeira extensora, remada sentada e cadeira flexora. O n??mero de repeti????es foi reduzido de acordo com o aumento da intensidade (mantendo a zona de repeti????es m??nima para cada ciclo de treinamento). A responsividade da PAS foi determinada com base no decl??nio percentual entre os momentos pr??-treinamento (mesociclo - T1) e p??s-treinamento (mesociclo - T4). O termo responsivo foi utilizado para descrever as idosas que apresentaram um decl??nio percentual da PAS = -2,58% e o termo n??o responsivo foi utilizado para descrever as idosas com decl??nio percentual da PAS < -2,58%. Ambos os grupos de idosas hipertensas responsivas e n??o responsivas apresentaram mudan??as significativas na PAS (-7,83 ?? 5,60 mmHg vs. 3,78 ?? 7,42 mmHg). Ademais, os grupos de idosas normotensas responsivas e n??o-responsivas tamb??m apresentaram mudan??as significativas na PAS (-8,58 ?? 5,52 mmHg vs. 5,71 ?? 3,84 mmHg). Al??m disso, an??lises estat??sticas foram realizadas utilizando a ANOVA de medidas repetidas, an??lise de covari??ncia (ANCOVA) e o modelo linear misto (MLM) para o c??lculo da RM e DR. A PAS inicial foi o preditor mais importante da resposta p??s-exerc??cio da PAS, conforme analisado pela ANCOVA e MLM. As redu????es de -2,24 mmHg n??o foram estatisticamente significativas e nem clinicamente importantes, mas ca??ram dentro do erro de medida. Portanto, a conclus??o do primeiro objetivo do estudo foi que a resposta da PAS ap??s 10 semanas de TF ?? heterog??nea em mulheres idosas hipertensas e normotensas. Por outro lado, para o segundo objetivo do estudo, incluir procedimentos estat??sticos para a melhor an??lise da RM e c??lculo da DR torna-se essencial para determinar o que ?? clinicamente importante, erro de medida e a melhor interpreta????o dos dados.

Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-08-09T14:34:10Z No. of bitstreams: 1 ManuelaSodreCabralDissertacao2018.pdf: 1598588 bytes, checksum: ec1d29656dd8913db6a03cee0051961e (MD5) Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-08-09T14:35:37Z (GMT) No. of bitstreams: 1 ManuelaSodreCabralDissertacao2018.pdf: 1598588 bytes, checksum: ec1d29656dd8913db6a03cee0051961e (MD5) Made available in DSpace on 2018-08-09T14:35:37Z (GMT). No. of bitstreams: 1 ManuelaSodreCabralDissertacao2018.pdf: 1598588 bytes, checksum: ec1d29656dd8913db6a03cee0051961e (MD5) Previous issue date: 2018-06-28 The growth of the elderly population is a worldwide phenomenon with direct consequences in public health systems. In Brazil, the Hyperdia program seeks to control prevention, diagnosis and treatment, as well as the planning of intervention strategies in hypertension and diabetes mellitus, aiming to delay their complications, since these are considered, among the chronic diseases, the most serious. The objective of this study was to compare the level of pain, strength and quality of life among elderly obese hypertensive patients and obese elderly diabetics. It is a quantitative cross-sectional study, carried out at the basic health units of the municipality of Barreiras / BA. The sample consisted of 52 participants, 35 hypertensive elderly obese and 17 obese diabetic elderly. All participants were enrolled with Hiperdia at least six months prior to the survey and respectively hypertensive and diabetic patients had: mean age of 68.3 ?? 6.4 years; 68.6 ?? 5.5 years, BMI 33.1 ?? 4.9 kg/m2; 33.7 ?? 8.8, kg/m2, respectivelly. The instruments applied were anthropometric measurements / body mass index; palmar grip strength; Visual Analogue Scale for Pain (EVA) and Quality of Life-old World Health Organization Questionnaire (WHOQOL-OLD). Results were expressed as mean ?? standard deviation (SD). To observe the normality of the data, the Shapiro-Wilk test was used. The results showed that the level of pain reported by hypertensive elderly patients (5.3 ?? 3.4) was statistically lower (p = 0.026) in the diabetic elderly group (7.4 ?? 2.4). In the parameter of quality of life, obese hypertensive elderly presented better scores in the sensory functioning facets and past, present and future activities. For the other parameters evaluated, no statistically significant differences were observed. This result is due to the problems of diabetes itself. It should be noted that, parameters of strength, pain, anthropometrics and hemodynamics are not related to quality of life, since this evaluation is perceptive and the elderly do not perceive the clinical characteristics as possible negative factors for their quality of life. O crescimento da popula????o idosa ?? um fen??meno mundial com consequ??ncias diretas nos sistemas de sa??de p??blica. No Brasil, por meio do programa Hiperdia, busca-se o controle da preven????o, do diagn??stico e do tratamento, bem como o planejamento de estrat??gias de interven????o na hipertens??o arterial e no diabetes mellitus, visando ao retardo de suas complica????es, uma vez que estas s??o consideradas, dentre as doen??as cr??nicas, as mais graves. O objetivo deste estudo foi comparar o n??vel de dor, for??a e qualidade de vida entre idosos obesos hipertensos e idosos obesos diab??ticos. Trata-se de um estudo quantitativo do tipo transversal realizado nas unidades b??sicas de sa??de do munic??pio de Barreiras/BA. A amostra foi constitu??da por 52 participantes, sendo 35 idosos obesos hipertensos e 17 idosos obesos diab??ticos. Todos os participantes eram cadastrados junto ao Hiperdia, no m??nimo, h?? seis meses anterior ?? pesquisa e hipertensos e diab??ticos possu??am: idade m??dia de 68,3 ?? 6,4 anos; 68,6 ?? 5,5 anos, IMC 33,1 ?? 4,9 kg/m2; 33,7 ?? 8,8 kg/m2, respectivamente. Os instrumentos aplicados foram medidas antropom??tricas/??ndice de massa corporal; for??a de preens??o palmar; Escala Visual Anal??gica (EVA) para dor e Question??rio World Health Organization Quality of Life-old (WHOQOL-OLD). Os resultados foram expressos em m??dia ?? desvio padr??o (DP). Para observar a normalidades dos dados, foi utilizado o teste Shapiro-Wilk. Os resultados demonstraram que o n??vel de dor relatado pelos idosos hipertensos (5,3 ?? 3,4) foi estatisticamente inferior (p = 0,026) ao grupo de idosos diab??ticos (7,4 ?? 2,4). No par??metro de qualidade de vida, os idosos obesos hipertensos apresentaram escores melhores nas facetas funcionamento sens??rio e atividades passadas, presentes e futuras. Para os demais par??metros avaliados, n??o foram observadas diferen??as estatisticamente significativas. Esse resultado se deve aos agravos pr??prios do diabetes. Cabe ressaltar que par??metros de for??a, dor, antropom??tricos e hemodin??micos n??o se relacionam com a qualidade de vida, uma vez que esta avalia????o ?? perceptiva e os idosos n??o percebem as caracter??sticas cl??nicas como poss??veis fatores negativos para sua qualidade de vida.

Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-07-20T20:21:48Z No. of bitstreams: 1 Jos?? Robertto Zaffalon J??nior.pdf: 1226797 bytes, checksum: 98ee59a170b7f0ef47fc560dd2ba5b1f (MD5) Made available in DSpace on 2018-07-20T20:21:48Z (GMT). No. of bitstreams: 1 Jos?? Robertto Zaffalon J??nior.pdf: 1226797 bytes, checksum: 98ee59a170b7f0ef47fc560dd2ba5b1f (MD5) Previous issue date: 2018-03-09 Subjects with a family history of hypertension (SAH) and Type 2 Diabetes Mellitus (DM2) presented early impairment in heart rate variability (HRV) when compared to those without family history. Despite previous studies reporting the benefits of physical exercise in hypertensive and diabetic subjects, the benefits of a physically active lifestyle in subjects with family history SAH and DM2, especially among young women, have not been fully evaluated. Therefore, the aim of this thesis was to analyze metabolic, hemodynamic and autonomic parameters at rest and in response to sympathetic stimulation in sedentary and physically active women with family history of SAH, DM2 or SAH+DM2. We performed a cross-sectional study with 105 women (age: 18 to 30 years). We evaluated: family history of SAH/DM2; level of physical activity; blood pressure; glycemia; HRV in the time and frequency domain by recording the R-R intervals. For better analysis, the thesis was divided in four studies. In the sStudy 1 we analyzed the quality of life and hemodynamic and autonomic parameters at rest and in response to a mental stress test of sedentary (SW=48) and active (AW=48) young women. The results provided evidence that sedentary lifestyles impaired autonomic cardiac modulation both at rest and in response to physiological stress and worsed quality of life. In the Study 2 we analyzed the HRV in offspring: of normotensive and normoglycemic (NND, n=14), of hypertensive (HD, n=13), of diabetic (DD, n=11), and of diabetic and hypertensive (DFD, n=11). The results showed that the family history of SAH and/or DM2 induced impairment in HRV before clinical cardiovascular or glycemic alterations. In the Study 3 we analyzed the impact of lifestyle on the autonomic cardiac modulation in women with a family history of DM2. We compared offspring of: normoglycemic sedentary (SDN, n = 14), diabetic sedentary (DSD, n=11) and diabetic active (DAD, n = 14). We demonstrated that physically active lifestyles improve cardiac autonomic modulation in diabetic offspring. In the Study 4 we evaluated the influence of the family history of hypertension associated to DM2 on HRV at rest and in response to a mental stress test. We evaluated sedentary offspring of normotensive and normoglycemic (SDNN, n=13), sedentary and active offspring of hypertensive (SHD, n=13 and SAH, n=14), and sedentary and active offspring of hypertensive and diabetic (SHD, n=11 and AHD, n=14). We showed that physically active lifestyles induced improvement on cardiac autonomic modulation of women with a family history of SAH, but that the association with the family history of DM2 is responsible for attenuation of these benefits, especially in response to a mental stress test. In summary, our results demonstrated impairment on HRV in women with family history of SAH and DM2, highlight the importance of a physically active lifestyle in the prevention of early autonomic dysfunctions associated with the development of SAH and DM2 in genetically predisposed women, and also reinforced the HRV analysis as a possible early marker of cardiovascular risk in this population. Indiv??duos com hist??rico familiar de hipertens??o arterial sist??mica (HAS) e Diabetes Mellitus do tipo 2 (DM2) apresentam precocemente preju??zo na variabilidade da frequ??ncia card??aca (VFC) quando comparados aos filhos de normotensos/normoglic??micos. Apesar de diversos estudos avaliarem os benef??cios do exerc??cio f??sico em hipertensos e diab??ticos, poucos analisaram a influ??ncia do estilo de vida fisicamente ativo em filhos de pais com HAS e DM2, principalmente entre mulheres jovens. Destarte, o objetivo desta tese foi analisar par??metros metab??licos, hemodin??micos e auton??micos em repouso e em resposta a estimula????o simp??tica de mulheres sedent??rias e fisicamente ativas com hist??rico familiar positivo de HAS, DM2 e HAS+DM2. Foi conduzido um estudo anal??tico transversal, com 105 mulheres (18 a 30 anos de idade). Foi avaliado: hist??rico familiar de HAS/DM2; n??vel de atividade f??sica; press??o arterial; glicemia; VFC no dom??nio do tempo e da frequ??ncia por meio do registro dos intervalos R-R. Os resultados foram divididos em quatro estudos. No estudo 1 foi analisada a qualidade de vida e os par??metros hemodin??micos e auton??micos em repouso e em resposta ao teste de estresse mental em mulheres jovens sedent??rias (MS=48) e fisicamente ativas (MA=48). Os achados evidenciaram que o sedentarismo em mulheres induziu preju??zo na modula????o auton??mica card??aca em repouso e em resposta ao estresse fisiol??gico e piorou a qualidade de vida, antes mesmo de alterar par??metros cl??nicos cardiovasculares ou metab??licos. No Estudo 2, foi comparada a VFC de mulheres filhas: de normotensos e normoglic??micos (FNN, n=14), de hipertensos (FH, n=13), de diab??ticos (FD, n=11) e de diab??ticos e hipertensos (FHD, n=11). Os resultados demonstraram que o hist??rico familiar de HAS e/ou DM2 induziu preju??zo na VFC antes de altera????es cl??nicas cardiovasculares ou glic??micas. No estudo 3 foi avaliado o impacto do estilo de vida sobre a modula????o auton??mica card??aca de mulheres com hist??rico familiar de DM2. Foram avaliadas filhas: sedent??rias de normoglic??micos (FSN, n=14), sedent??rias de diab??ticos (FSD, n=11) e ativas de diab??ticos (FAD, n=14), concluindo que o estilo de vida fisicamente ativo foi associado a melhor modula????o auton??mica card??aca do grupo FAD. No Estudo 4 foi avaliado a influ??ncia do hist??rico familiar de HAS associado ou n??o ?? DM2 sobre a VFC em repouso e em resposta a um teste de estresse mental de mulheres sedent??rias e fisicamente ativas. Foram avaliadas filhas: sedent??rias de normotensos e normoglic??micos (FSNN, n=14), sedent??rias de hipertensos (FSH, n=13), ativas de hipertensos (FAH, n=14); e sedent??rias de hipertensos e diab??ticos (FSHD, n=11) e ativas de hipertensos e diab??ticos (FAHD, n=14). Os achados deste estudo mostraram que o estilo de vida fisicamente ativo ?? respons??vel pela melhor modula????o auton??mica card??aca de mulheres com hist??rico familiar de HAS, mas que a associa????o com o hist??rico de DM2 atenua estes benef??cios, n??o s?? na condi????o de repouso, mas principalmente frente ao teste de estresse mental. Em conjunto nossos resultados evidenciam preju??zo na VFC em mulheres com hist??rico familiar de HAS e/ou DM2, ressaltam a import??ncia de uma vida fisicamente ativa na preven????o de disfun????es auton??micas precoces associadas ao desenvolvimento de HAS e DM2 em mulheres geneticamente predispostas, e refor??am a an??lise da VFC como um poss??vel marcador precoce de risco cardiovascular nessa popula????o.

Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-04-05T20:33:17Z No. of bitstreams: 1 JoseFernandodeOliveiraTese2017.pdf: 2874980 bytes, checksum: 2f96c863658b7f42f17e67ca0b4ea1a1 (MD5) Made available in DSpace on 2017-04-05T20:33:17Z (GMT). No. of bitstreams: 1 JoseFernandodeOliveiraTese2017.pdf: 2874980 bytes, checksum: 2f96c863658b7f42f17e67ca0b4ea1a1 (MD5) Previous issue date: 2016-12-14 Systemic arterial hypertension is a global health problem, affecting even the adolescent population, in this age group, genetic predisposition and biopsychosocial modifications are important factors in the development of hypertension. However, few studies have analyzed and associated the combination of family history, physical activity level, anthropometric profile and physical fitness on blood pressure reactivity and nitric oxide bioavailability in adolescents submitted to the Shuttle Run 20 meters, Cold Pressor Test and palmar grip strength. A total of 172 adolescents (n = 60???, n = 112???), high school students of the Technical College of Campinas-SP, aged 14 to 18 years, were classified into: normotensive children (FN; = 38???, n = 48???) and hypertensive children (FH; n = 22???; n = 64???), subdivided into active and sedentary. All procedures followed the ethical requirements of resolution 466/12 of the National Health Council. The results showed significant differences between FN vs. FH in several parameters of physical fitness, hemodynamic components and in salivary nitrite. Therefore, this study demonstrated that FH adolescents already present a negative influence of anthropometric, cardiovascular and physical activity levels on the bioavailability of salivary nitric oxide in children of hypertensive patients. A hipertens??o arterial sist??mica ?? um problema mundial de sa??de, afetando inclusive a popula????o adolescente, nessa faixa et??ria, a predisposi????o gen??tica e as modifica????es biopsicossociais s??o importantes fatores no que tangem ao desenvolvimento da HAS. Entretanto poucos estudos analisaram e associaram a combina????o do hist??rico familiar, n??vel de atividade f??sica, perfil antropom??trico e a aptid??o f??sica na reatividade press??rica e a biodisponibilidade de ??xido n??trico em adolescentes submetidos ao Shuttle Run 20 metros, Cold Pressor Test e for??a de preens??o palmar. Foram avaliados 172 adolescentes (n=60???; n=112???), alunos do ensino m??dio do Col??gio T??cnico de Campinas-SP, com idades variando entre 14 e 18 anos, os quais foram classificados em: filhos de normotensos (FN; n=38???; n=48???) e filhos de hipertensos (FH; n=22???; n=64???), subdivididos em ativos e sedent??rios. Todos os procedimentos seguiram as exig??ncias ??ticas da resolu????o 466/12 do conselho nacional de sa??de. Os resultados demonstraram diferen??as significativas entre FN vs. FH em diversos par??metros de aptid??o f??sica, componentes hemodin??micos e no nitrito salivar. Portanto, este estudo demonstrou que adolescentes FH j?? apresentam uma influ??ncia negativa de vari??veis antropom??tricas, cardiovasculares e n??vel de atividade f??sica na biodisponibilidade de oxido n??trico salivar em filhos de hipertensos.

Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-04-18T12:39:20Z No. of bitstreams: 1 PauladosSantosSilvaDissertacao2015.pdf: 1389629 bytes, checksum: b4af7cc03bec3563157504471bbec82e (MD5) Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-04-18T12:39:29Z (GMT) No. of bitstreams: 1 PauladosSantosSilvaDissertacao2015.pdf: 1389629 bytes, checksum: b4af7cc03bec3563157504471bbec82e (MD5) Made available in DSpace on 2017-04-18T12:39:29Z (GMT). No. of bitstreams: 1 PauladosSantosSilvaDissertacao2015.pdf: 1389629 bytes, checksum: b4af7cc03bec3563157504471bbec82e (MD5) Previous issue date: 2015-12-09 Longevity has important implications for the quality of life and may cause problems with serious consequences in the different spheres of human life, such as physical, psychological and social. For the elderly with hypertension, uncontrolled, more years lived, can mean more years of suffering, since it becomes necessary to accept the disease and sudden change in lifestyle. Therefore, the objective of this study was to compare the quality of life in normotensive elderly and hypertensive elderly assisted in HIPERDIA Program. It is a quantitative survey of cross-sectional design. The participants were 80 elderly residents in the city of Barreiras-BA, aged over 60 years. Three instruments were used for data collection: WOQOL-OLD questionnaire validated in Brazil by Fleck in 2006, the IPAQ, validated and adapted for the elderly in Brazil Mazo; Benedetti in 2010 and CCEB proposed by the National Association of Companies Research (ANEP) that allowed to evaluate the economic classification of the participants. To compare the quality of life scores, as well as compare the weekly volume of each activity among the groups we used the unpaired t test. The result was that elderly hypertensive patients have impaired quality of life, which corroborates the hypothesis of this study and the two groups can be considered sedentary not shown correlation of physical exercise with the quality of life. As the economic classification, the elderly are poor, framed, therefore, in economy class D. Longevity has important implications for the quality of life and may cause problems with serious consequences in the different spheres of human life, such as physical, psychological and social. For the elderly with hypertension, uncontrolled, more years lived, can mean more years of suffering, since it becomes necessary to accept the disease and sudden change in lifestyle. Therefore, the objective of this study was to compare the quality of life and level of well-being in normotensive elderly and hypertensive elderly assisted in HIPERDIA Program. It is a quantitative survey of cross-sectional design. The participants were 80 elderly residents in the city of Barreiras-BA, aged over 60 years. Three instruments were used for data collection: WOQOL-OLD questionnaire validated in Brazil by Fleck in 2006, the IPAQ, validated and adapted for the elderly in Brazil Mazo& Benedetti in 2010 and CCEB proposed by the Associa????o Nacional de Empresas de Pesquisa (ANEP) that allowed to evaluate the economic classification of the participants. To compare the quality of life scores, as well as compare the weekly volume of each activity among the groups we used the unpaired t test. The result was that elderly hypertensive patients have impaired quality of life, which corroborates the hypothesis of this study and the two groups can be considered sedentary not shown correlation of physical exercise with the quality of life. As the economic classification, the elderly are poor, framed, therefore, in economy class D. A longevidade possui implica????es importantes para a qualidade de vida, podendo acarretar problemas com consequ??ncias s??rias nas diferentes esferas da vida humana, como f??sica, ps??quica e social. Para o idoso com doen??a hipertensiva, n??o controlada, mais anos vividos, podem significar mais anos de sofrimento, uma vez que se torna necess??ria a aceita????o da doen??a e a mudan??a brusca no estilo de vida. Por tanto, o objetivo deste estudo, foi comparar a qualidade de vida de idosos normotensos com idosos hipertensos assistidos no Programa HIPERDIA. Trata-se de uma pesquisa de quantitativa de delineamento transversal. Participaram da pesquisa 80 idosos residentes no munic??pio de Barreiras-BA, com idade igual ou superior a 60 anos. Foram utilizados tr??s instrumentos para a coleta de dados: question??rio WOQOL-OLD, validado no Brasil por Fleck em 2006, o question??rio IPAQ, validado e adaptado para o idoso no Brasil por Mazo; Benedetti em 2010 e CCEB proposto pela Associa????o Nacional de Empresas de Pesquisa (ANEP) que permitiu avaliar a classifica????o econ??mica dos participantes. Para comparar os escores de qualidade de vida, bem como, comparar o volume semanal de cada atividade entre os grupos foi utilizado o teste t n??o pareado. O resultado foi que idosos hipertensos possuem qualidade de vida prejudicada, o que corrobora com a hip??tese deste estudo e os dois grupos podem ser considerados sedent??rios n??o apresentado correla????o do exerc??cio f??sico com a qualidade de vida. Quanto a classifica????o econ??mica, os idosos possu??am baixa renda, enquadrado, por tanto, na classe econ??mica D.

Submitted by Kamila Costa (kamilavasconceloscosta@gmail.com) on 2015-06-24T21:12:18Z No. of bitstreams: 1 Disserta????o-Pedro H D F de Castro.pdf: 2920916 bytes, checksum: f78e41ed3a1933329613eeb2337d5f57 (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2015-07-09T18:56:39Z (GMT) No. of bitstreams: 1 Disserta????o-Pedro H D F de Castro.pdf: 2920916 bytes, checksum: f78e41ed3a1933329613eeb2337d5f57 (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2015-07-09T18:54:32Z (GMT) No. of bitstreams: 1 Disserta????o-Pedro H D F de Castro.pdf: 2920916 bytes, checksum: f78e41ed3a1933329613eeb2337d5f57 (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2015-07-09T19:01:08Z (GMT) No. of bitstreams: 1 Disserta????o-Pedro H D F de Castro.pdf: 2920916 bytes, checksum: f78e41ed3a1933329613eeb2337d5f57 (MD5) Made available in DSpace on 2015-07-09T19:01:08Z (GMT). No. of bitstreams: 1 Disserta????o-Pedro H D F de Castro.pdf: 2920916 bytes, checksum: f78e41ed3a1933329613eeb2337d5f57 (MD5) Previous issue date: 2015-02-27 N??o Informada This was an observational, cross-sectional, descriptive and analytical study, which aimed to estimate the prevalence of dental caries, characterize socioeconomic variables, lifestyle, oral morbidity, use of services and to analyze the association of these variables with impact on oral health-related quality of life (OHRQoL) in hypertensive patients. Data were analyzed using chi-square test, Mann-Whitney and Fisher, followed by logistic regression. The prevalence of impact on OHRQoL was 70%, estimated by OHIP-14. In univariate analysis, there was a statistically significant difference between individuals with and without impact for the variables toothache in the last 6 months (p

Submitted by Nadir Basilio (nadirsb@uninove.br) on 2015-07-20T18:01:54Z No. of bitstreams: 1 Suely Tomimura.pdf: 1781054 bytes, checksum: acaac7dbd088721fbe65530e5cd96c5f (MD5) Made available in DSpace on 2015-07-20T18:01:54Z (GMT). No. of bitstreams: 1 Suely Tomimura.pdf: 1781054 bytes, checksum: acaac7dbd088721fbe65530e5cd96c5f (MD5) Previous issue date: 2013-12-17 Due to the increasing numbers of Systemic Arterial Hypertension (HBP) patients in population and its senescence, steadily increased from 600 million in 1980 to 1.2 billion in 2008. The World Health Organization (WHO) in 2009 attributed to high blood pressure (BP) was the death cause for 9.5 million people worldwide. Currently, the hypertension has become a serious public health problem. This entity is an important risk factor for congestive heart failure, cerebrovascular disease, acute myocardial infarction, nephropathy, retinopathy and peripheral vascular insufficiency. Studies have suggested that laser photobiomulation, employing a low power, acts into the inflammatory and proliferative phases of tissue repair, by modulating the inflammatory mediators synthesis as same as the Reactive Oxygen Species (ROS). According scientific publications indicate that the inflammation component is closely related to systemic arterial hypertension as well as possibly to the oxidative stress, both participates in the Hypertension genesis. The aim of this study was to verify the long-term effects of Low Level Laser Therapy (LLLT) application in Spontaneously Hypertensive Rats-SHR (Spontaneously Hypertensive Rats) through on cardiovascular autonomic modulation and oxidative stress in the blood. The experiment consisted in 3 phases: Phase I ??? LLLT irradiation on SHR: The experiment's phase I consisted of animal???s irradiation, when the laser group received three times LLLT applications weekly for a 7 weeks total; the sham group received three times per week of LLLT simulation for 7 weeks and a total of 21 applications. Prospective, randomized, controlled study, with 16 SHR approximately 2 months age, randomly divided into 2 groups : Sham (n = 8) and Laser (n = 8). The animals were irradiated in a prompt, onto the tail???s dorsal area, using a Diode Laser (MMOptics, S??o Carlos, SP, Brazil) with a wavelength (??) of 780 ?? 2 (nm), output power at 40 mW, with a 0.04 cm2 beam area, dose of 30 J/cm2 power density of 1W/cm2 and irradiation time of 90 s. In Phase II - Hemodynamic and autonomic cardiovascular evaluation: for a period of 7 weeks, consisted in the cannulation procedure, collecting and analysis. The animals were cannulated, evaluated hemodynamically and analyzed the cardiovascular autonomic modulation. Phase III - Oxidative stress analysis, were analyzed: a) protein damage; b) cell membrane damage; c) antioxidant enzyme activity; d) nitrite concentrations. Data from phase II and III were collected and statistically analyzed applying One Way ANOVA test, followed by post hoc Student - Newman Keulls and considering the significance level of p < 0.05, equivalent to an error ?? 0.05. The results demonstraded hemodynamic parameters of group LLLT treated showed a BP reduction, when compared with the Sham group. In laser group the diastolic arterial pressure (DAP) showed a reduction of -14 mmHg (?? 143 * 4 x 157 ?? 3 mmHg Sham) and mean arterial pressure (MAP) - 13mmHg (169 ?? 4 * x 182 ?? 4 mmHg Sham) there were statistically significant difference. Although the value of systolic arterial pressure (SAP) (196 ?? 5 x 207 ?? 4 mmHg) showed no differences. There was a decreased in resting HR with a statistically significant difference in the laser group compared to Sham (312 ?? 14 vs. 361 ?? 13 bpm sham). The spectral reviews in the field of time and frequency showed that the Laser group decreased sympathetic activity on the heart and blood vessels while compared to the Sham group. The heart rate variation was analyzed using the DP-PI ( standard deviation of the pulse interval) VAR-PI components (pulse interval variability) and it demonstrated that LLLT was effective in diminishing variation in heart rate (HR) and sympathetic activity in heart, inducing a substantial fall in blood pressure. Lasertherapy presented a rise in spectral low-frequency component in the pulse interval (LF - IP action of the sympathetic at heart), though the sham group showed up exaggeratedly decreasing (6.77 ?? 4:35 and 2:31 ?? 0:16 ms ?? Sham) as a function of saturation variation. Thus, there was a significant reduction in sympathetic activity after LLLT using. A high-frequency band on interval pulse HF-IP (parasympathetic activity) showed no statistically significant differences between the groups and Laser Sham group. The baroreceptor sensitivity, assessed by the alpha index, signalized a significant increase in the Laser (1:07 ?? 0:23 vs. 0:45 ?? 0:20 ms / mmHg Sham) group, presenting an improvement in the receptors sensitivity. The baroreflex results were associated with other relevant data, the VAR - SAP (49.55 ?? 15.94 * vs 70.51 ?? 13:55 mmHg?? Sham) and SD -SAP (6.94 ?? 1.21 * vs 8.68 ?? 1.11 mmHg Sham) that proved to be diminished in the laser group, indicating baroreflex improvement sensitivity concomitantly to the positive SAP variation reduction of. There were no significant differences in baseline SAP (196 ?? 5 vs. 207 ?? 4 mmHg Sham) between the two groups. The results in the oxidative stress and autonomic analysis demonstrated an association between increased NO production (nitrite 0:36 ?? 0:03 vs 0:26 ?? 0:03 nm / mg Sham) and decreased in the vascular sympathetic (LF - SAP 7.28 ?? 1.63 * vs 9.86 ?? 0.47 Sham), both leading to a profound vasodilatation then a significant fall in of blood pressure. Lasertherapy shown to alter the plasma parameters such as oxidative nitrite, revealing an NO increased metabolism, as described above and, moreover, accounted for a significant reduction in carbonyl plasma concentration (vs 3.93 ?? 0.24, 4.75 ?? 0:26 * nm / mg Sham). Our experimental study indicate that LLLT was able to reduce the oxidative stress parameters through diminishing the damage to the proteins. The enzymatic defense was analyzed by the enzyme SOD concentration in blood plasma, denoted that no significant differences (4:42 ?? 0:10 4:25 ?? 0:06 vs usod / mg) between groups. Thus, low level laser therapy has shown to improve cardiovascular autonomic activity as well as oxidative parameters which resulted in steadily staggeringly reduce the blood pressure of hypertensive animals. Em raz??o do aumento populacional e a senesc??ncia, o n??mero de indiv??duos com Hipertens??o Arterial Sist??mica (HAS) cresceu de 600 milh??es em 1980 para 1,2 bilh??es (OMS 2011). Lim (2012) atribuiu que a press??o arterial (PA) elevada fosse a causa mortis de 9,5 milh??es de indiv??duos ao redor do mundo. Atualmente, a HAS tornou-se um grave problema de sa??de p??blica. A hipertens??o ?? um importante fator de risco para insufici??ncia card??aca congestiva, doen??as cerebrovasculares, infarto agudo do mioc??rdio, nefropatia, insufici??ncia vascular perif??rica e retinopatia hipertensiva. Considerando publica????es cient??ficas que demonstram que o componente da inflama????o e do estresse oxidativo est??o intimamente relacionados ?? g??nese da hipertens??o arterial sist??mica (HAS), e que o laser com pot??ncia baixa tem efeito positivo no estresse oxidativo e apresenta a????o antiinflamat??ria eficaz, desta forma buscamos estudar a resposta da Laserterapia na HAS. In??meros estudos v??m sugerindo, ao longo de d??cadas, que a fotobiomula????o pelo laser empregado uma pot??ncia baixa, atua durante as fases inflamat??rias e proliferativas da repara????o tissular, modulando s??ntese de mediadores inflamat??rios e esp??cies reativas de oxig??nio (ROS). O objetivo deste estudo foi analisar os efeitos da aplica????o do laser de baixa intensidade em ratos espontaneamente hipertensos SHR (Spontaneously Hypertensive Rats) em longo prazo na modula????o auton??mica cardiovascular e no estresse oxidativo sang??ineo. Estudo prospectivo, randomizado e controlado com 16 ratos SHR, divididos aleatoriamente em 2 grupos: Sham (n=8) e Laser (n=8).O experimento foi dividido em tr??s fases: Fase I ??? Irradia????o dos animais: constituiu-se na irradia????o com laser nos animais SHR, onde o grupo Laser recebeu tr??s aplica????es semanais de LBI durante sete semanas; j?? no grupo Sham foram realizados tr??s simula????es de aplica????o semanais de Laser de Baixa Intensidade (LBI) durante 7 semanas, totalizando 21 aplica????es de LBI. Os animais foram irradiados pontualmente, na regi??o dorsal da cauda, utilizando um Laser Diodo (MMOptics, S??o Carlos, SP, Brasil) com comprimento de onda de ?? = 780 ?? 2 (nm); pot??ncia de 40 mW, ??rea do feixe de 0,04 cm2, densidade de energia de 30 J/cm2, densidade de pot??ncia de 1W/cm2, tempo total de irradia????o de 90 s de exposi????o. Fase II ??? Avalia????o hemodin??mica e auton??mica cardiovascular: constituiu-se nos procedimento de canula????o, registro de dados e coleta de material, teve inicio ap??s sete semanas de irradia????o. Os animais canulados foram avalidados de forma hemodin??mica, bem como analisada a modula????o auton??mica cardiovascular. Fase III ??? An??lises do estresse oxidativo, foram analisadas: a) danos ?? prote??na; b) danos ?? membrana celular; c) atividade enzim??tica; d) concentra????o de nitrito. Os dados da fase II e III foram coletados e analisados estatisticamente atrav??s dos testes Anova One Way, seguido de Post Hoc de Student Newman-Keulls, considerando-se o n??vel de signific??ncia p < 0,05, equivalendo a um erro ?? de 0.05. Os resultados hemodin??micos do grupo tratado com LLLT denotaram um decr??scimo significativo da PA quando comparado com o grupo Sham. A press??o arterial diast??lica (PAD) do grupo Laser revelou uma redu????o de -14 mmHg (143?? 4*vs157??3 mmHg Sham) e a press??o arterial m??dia (PAM) -13mmHg (169??4*vs182??4 mmHg Sham), a frequ??ncia card??aca (FC) em repouso (312??14*vs361??13 bpm Sham) revelando uma diferen??a estatisticamente significante, por??m o valor da press??o arterial sist??lica(PAS) n??o mostrou (196??5 x 207??4 mmHg) altera????es entre os grupos. As avalia????es espectrais no dom??nio do tempo e da frequencia demostraram que o grupo Laser reduziu a atividade simp??tica sobre o cora????o e vasos sangu??neos quando comparados ao grupo Sham. A varia????o frequ??ncia card??aca foi analisada atrav??s dos componentes VAR-IP (variabilidade do intervalo de pulso) e o DP-IP (desvio do intervalo de pulso) que evidenciaram que o LBI foi eficaz no decr??scimo varia????o da FC e da atividade simp??tica no cora????o, induzindo assim a queda das press??es arteriais. A laserterapia mostrou um incremento no componente espectral baixa frequ??ncia no intervalo de pulso (BF-IP a????o do simp??tico no cora????o), por??m o grupo Sham apresentou-se exacerbadamente diminu??do (6.77 ?? 4.35 e 2.31??0.16 ms?? Sham) em fun????o da satura????o da varia????o desse componente que foi reduzido. Desta forma, houve um importante decr??scimo da atividade simp??tica com o uso do LBI, significando uma importante diminui????o dos n??veis press??ricos. A banda de alta frequ??ncia (AF-IP atividade parassimp??tica card??aca) n??o mostrou diferen??as estat??sticas significantes entre os grupos Laser e grupo Sham. A sensibilidade dos barorreceptores, avaliada pelo ??ndice alfa, demonstrou um significativo incremento da resposta no grupo Laser (1.07 ?? 0.23 vs 0.45 ?? 0.20 ms/mmHg Sham), revelando uma melhora na sensibilidade destes receptores. Os resultados dos barorreflexos encontravam-se associados a outro dado relevante, o componente VAR-PAS (49.55 ?? 15.94* vs 70.51 ?? 13.55 mmHg?? Sham) e DP-PAS (6.94 ?? 1.21* vs 8.68 ?? 1.11 mmHg Sham) que mostrou-se diminu??do no grupo Laser, indicando que a melhora da sensibilidade barorreflexa ocorreu, concomitantemente, ?? redu????o positiva da varia????o da PAS. N??o houve diferen??as estat??sticas significantes na PAS basal (196??5 vs 207 ?? 4 mmHg Sham) entre os dois grupos. J?? os resultados encontrados na an??lise do estresse oxidativo e auton??mica demonstraram uma associa????o entre o incremento da produ????o do ??xido nitrico (NO) (nitrito 0.36 ?? 0.03 vs 0.26 ?? 0.03 nm/mg Sham) e redu????o do simp??tico vascular (BF-PAS 7.28 ?? 1.63* vs 9.86 ?? 0.47 Sham), ambos levando a uma vasodilata????o com consequente queda dos n??veis press??ricos arteriais. A laserterapia mostrou alterar par??metros oxidativos como as esp??cies reativas de nitrog??nio (RNS reactive nitrogen species), o nitrito plasm??tico, revelando um aumento do metabolismo do NO, como j?? descrito anteriormente e denotou uma diminui????o significativa da concentra????o de carbonilas plasm??ticas (3.93 ?? 0.24 * vs 4.75 ?? 0.26 nm/mg Sham). A defesa enzim??tica foi analisada atrav??s da concentra????o da enzima SOD no plasma sangu??neo, que n??o apontou diferen??as significativas (4.42 ?? 0.10 vs 4.25 ?? 0.06 usod/mg) entre os grupos. Evidenciamos que o LBI foi capaz de reduzir este par??metro oxidativo, reduzindo os danos ??s prote??nas decorrente do estresse. Desta forma, conclu??mos que a laserterapia demonstrou resposta positiva ao melhorar a atividade auton??mica cardiovascular e par??metros oxidativos que resultaram na redu????o dos n??veis press??ricos dos animais hipertensos.

Submitted by Nadir Basilio (nadirsb@uninove.br) on 2015-07-27T14:59:47Z No. of bitstreams: 1 Josiane Motta e Motta.pdf: 1112413 bytes, checksum: 56336232aa8fd9a87ed00d49c5689dd5 (MD5) Made available in DSpace on 2015-07-27T14:59:47Z (GMT). No. of bitstreams: 1 Josiane Motta e Motta.pdf: 1112413 bytes, checksum: 56336232aa8fd9a87ed00d49c5689dd5 (MD5) Previous issue date: 2013-01-13 The scientific literature confirms that metabolic, autonomic and anthropometric changes are commonly present in patients with arterial hypertension (AH). Offspring of hypertensive parents show since childhood some metabolic and autonomic changes, like glucose intolerance, increased lipid and catecholamines levels and a higher blood pressure than offspring of normotensive parents. Few studies have evaluated the heart rate variability in sons of hypertensive parents.Objective. The aim of this prospective randomized study was to assess anthropometric, hemodynamic and metabolic changes as well as changes in sympathetic-vagal imbalances after carbohydrate overload in offspring of hypertensive parents. Methods. In phase one, 200 volunteers were prospectively evaluated. Their hemodynamic variables were probed with HDI (Hypertension Diagnosis Incorporation, CR2000, Eagan, USA), a stress analysis was done through social readjustment scale of Holmes-Rahe and anthropometric assessment included measurement of cervical and abdominal circumferences, evaluation of lean and fat body mass and metabolic rate through bioimpedance. Part of the group as submitted to a carbohydrates overload to evaluate the autonomic imbalance. Results. Data did not meet statistical differences in lean and fat mass as well as in neck circumference and stress evaluation for offspring of hypertensive parents and the control group. However, offspring of hypertensive parents showed higher (p