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326 results on '"Hinrichsen, Holger"'

1. Seladelpar efficacy and safety at 3 months in patients with primary biliary cholangitis: ENHANCE, a phase 3, randomized, placebo-controlled study.

Author

Hirschfield, Gideon M, Shiffman, Mitchell L, Gulamhusein, Aliya, Kowdley, Kris V, Vierling, John M, Levy, Cynthia, Kremer, Andreas E, Zigmond, Ehud, Andreone, Pietro, Gordon, Stuart C, Bowlus, Christopher L, Lawitz, Eric J, Aspinall, Richard J, Pratt, Daniel S, Raikhelson, Karina, Gonzalez-Huezo, Maria S, Heneghan, Michael A, Jeong, Sook-Hyang, Ladrón de Guevara, Alma L, Mayo, Marlyn J, Dalekos, George N, Drenth, Joost PH, Janczewska, Ewa, Leggett, Barbara A, Nevens, Frederik, Vargas, Victor, Zuckerman, Eli, Corpechot, Christophe, Fassio, Eduardo, Hinrichsen, Holger, Invernizzi, Pietro, Trivedi, Palak J, Forman, Lisa, Jones, David EJ, Ryder, Stephen D, Swain, Mark G, Steinberg, Alexandra, Boudes, Pol F, Choi, Yun-Jung, McWherter, Charles A, and ENHANCE Study Group*

Subjects
ENHANCE Study Group*, Humans, Liver Cirrhosis, Biliary, Pruritus, Acetates, Ursodeoxycholic Acid, Alkaline Phosphatase, Cholagogues and Choleretics, Digestive Diseases, Liver Disease, Rare Diseases, Clinical Trials and Supportive Activities, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Medical Biochemistry and Metabolomics, Clinical Sciences, Immunology, Gastroenterology & Hepatology
Abstract

Background and aimsENHANCE was a phase 3 study that evaluated efficacy and safety of seladelpar, a selective peroxisome proliferator-activated receptor-δ (PPAR) agonist, versus placebo in patients with primary biliary cholangitis with inadequate response or intolerance to ursodeoxycholic acid (UDCA).Approach and resultsPatients were randomized 1:1:1 to oral seladelpar 5 mg (n=89), 10 mg (n=89), placebo (n=87) daily (with UDCA, as appropriate). Primary end point was a composite biochemical response [alkaline phosphatase (ALP) < 1.67×upper limit of normal (ULN), ≥15% ALP decrease from baseline, and total bilirubin ≤ ULN] at month 12. Key secondary end points were ALP normalization at month 12 and change in pruritus numerical rating scale (NRS) at month 6 in patients with baseline score ≥4. Aminotransferases were assessed. ENHANCE was terminated early following an erroneous safety signal in a concurrent, NASH trial. While blinded, primary and secondary efficacy end points were amended to month 3. Significantly more patients receiving seladelpar met the primary end point (seladelpar 5 mg: 57.1%, 10 mg: 78.2%) versus placebo (12.5%) ( p < 0.0001). ALP normalization occurred in 5.4% ( p =0.08) and 27.3% ( p < 0.0001) of patients receiving 5 and 10 mg seladelpar, respectively, versus 0% receiving placebo. Seladelpar 10 mg significantly reduced mean pruritus NRS versus placebo [10 mg: -3.14 ( p =0.02); placebo: -1.55]. Alanine aminotransferase decreased significantly with seladelpar versus placebo [5 mg: 23.4% ( p =0.0008); 10 mg: 16.7% ( p =0.03); placebo: 4%]. There were no serious treatment-related adverse events.ConclusionsPatients with primary biliary cholangitis (PBC) with inadequate response or intolerance to UDCA who were treated with seladelpar 10 mg had significant improvements in liver biochemistry and pruritus. Seladelpar appeared safe and well tolerated.

Published
2023

2. Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn’s disease

Author

Martini, Gabriela Rios, Tikhonova, Ekaterina, Rosati, Elisa, DeCelie, Meghan Bialt, Sievers, Laura Katharina, Tran, Florian, Lessing, Matthias, Bergfeld, Arne, Hinz, Sophia, Nikolaus, Susanna, Kümpers, Julia, Matysiak, Anna, Hofmann, Philipp, Saggau, Carina, Schneiders, Stephan, Kamps, Ann-Kristin, Jacobs, Gunnar, Lieb, Wolfgang, Maul, Jochen, Siegmund, Britta, Seegers, Barbara, Hinrichsen, Holger, Oberg, Hans-Heinrich, Wesch, Daniela, Bereswill, Stefan, Heimesaat, Markus M., Rupp, Jan, Kniemeyer, Olaf, Brakhage, Axel A., Brunke, Sascha, Hube, Bernhard, Aden, Konrad, Franke, Andre, Iliev, Iliyan D., Scheffold, Alexander, Schreiber, Stefan, and Bacher, Petra

Published
2023
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3. A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B

Author

van Bömmel, Florian, Stein, Kerstin, Heyne, Renate, Petersen, Jörg, Buggisch, Peter, Berg, Christoph, Zeuzem, Stefan, Stallmach, Andreas, Sprinzl, Martin, Schott, Eckart, Pathil-Warth, Anita, von Arnim, Ulrike, Keitel, Verena, Lohmeyer, Jürgen, Simon, Karl-Georg, Trautwein, Christian, Trein, Andreas, Hüppe, Dietrich, Cornberg, Markus, Lammert, Frank, Ingiliz, Patrick, Zachoval, Reinhart, Hinrichsen, Holger, Zipprich, Alexander, Klinker, Hartmuth, Schulze zur Wiesch, Julian, Schmiedeknecht, Anett, Brosteanu, Oana, and Berg, Thomas

Published
2023
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4. Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1–3 Infections

Author

Balavoine, J., Giostra, E., Berning, M., Hampe, J., De Gottardi, A., Rauch, A., Semmo, N., Discher, T., Trauth, J., Fischer, J., Gress, M., Günther, R., Heinzow, H., Schmidt, J., Herrmann, A., Stallmach, A., Hilgard, G., Deterding, K., Lange, C.M., Ciesek, S., Wedemeyer, H., Hoffmann, D., Klinker, H., Schulze, P., Kocheise, F., Müller-Schilling, M., Kodal, A., Kremer, A., Ganslmayer, M., Siebler, J., Lammert, F., Rissland, J., Löbermann, M., Götze, T., Canbay, A., Lohse, A., von Felden, J., Jordan, S., Maieron, A., Moradpour, D., Chave, J.-P., Moreno, C., Müller, T., Muche, M., Epple, H.-J., Port, K., von Hahn, T., Cornberg, M., Manns, M., Reinhardt, L., Ellenrieder, V., Rockstroh, J., Schattenberg, J., Sprinzl, M., Galle, P., Roeb, E., Steckstor, M., Schmiegel, W., Brockmeyer, N.H., Seufferlein, T., Stremmel, W., Strey, B., Thimme, R., Teufel, A., Vogelmann, R., Ebert, M., Tomasiewicz, K., Trautwein, C., Tacke, F., Koenen, T., Weber, T., Zachoval, R., Mayerle, J., Raziorrouh, B., Angeli, W., Beckebaum, S., Doberauer, C., Durmashkina, E., Hackelsberger, A., Erhardt, A., Garrido-Lüneburg, A., Gattringer, H., Genné, D., Gschwantler, M., Gundling, F., Hametner, S., Schöfl, R., Hartmann, C., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschläger, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Audebert, F., Baermann, C., Bästlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtländer, A., Böhm, G., Börner, N., Bohr, U., Bokemeyer, B., Bruch, H.R., Bucholz, D., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Hüppe, D., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H.R., Glas, M., Glaunsinger, T., Goebel, F., Göbel, U., Görlitz, B., Graf, R., Gruber, H., Härter, G., Herder, M., Heuchel, T., Heuer, S., Höffl, K.-H., Hörster, H., Sonne, J.-U., Hofmann, W.P., Holst, F., Hunstiger, M., Hurst, A., Jägel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Klüppelberg, U., Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Körfer, A., Köster, A., Kuhn, M., Langekamp, A., Künzig, B., Link, R., Littman, M., Löhr, H., Lutz, T., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mayer, C., Meister, V., Möller, H., Heyne, R., Moritzen, D., Mroß, M., Mundlos, M., Naumann, U., Nehls, O., Ningel, K.&R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Petersen, J., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rössle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, K.J., Schmidt, W., Schmidt-Heinevetter, G., Schmidtler-von Fabris, J., Schnaitmann, E., Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K.G., Stähler, D., Stenschke, F., Steffens, H., Stein, K., Steinmüller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., Zipf, A., Dietz, Julia, Spengler, Ulrich, Müllhaupt, Beat, Schulze zur Wiesch, Julian, Piecha, Felix, Mauss, Stefan, Seegers, Barbara, Hinrichsen, Holger, Antoni, Christoph, Wietzke-Braun, Perdita, Peiffer, Kai-Henrik, Berger, Annemarie, Matschenz, Katrin, Buggisch, Peter, Backhus, Johanna, Zizer, Eugen, Boettler, Tobias, Neumann-Haefelin, Christoph, Semela, David, Stauber, Rudolf, Berg, Thomas, Berg, Christoph, Zeuzem, Stefan, Vermehren, Johannes, and Sarrazin, Christoph

Published
2021
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5. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Author

Gadano, Adrian, Martins, Marcelo, Angus, Peter, Bate, John, Danta, Mark, George, Jacob, Hodge, Alexander, Kontorinis, Nickolas, Roberts, Stuart, Sanagapalli, Santosh, Skoien, Richard, Thompson, Alexander, Zekry, Amany, Stauber, Rudolf, Trauner, Michael, Moreno, Christophe, Reynaert, Hendrik, Verbeke, Len, Silva, Mario Reis Alvares da, Parise, Edison, Oliveira, Claudia Pinto Marques Souza de, Araujo, Roberta Chaves, Martinelli, Ana de Lourdes Candolo, Borman, Meredith, Chandok, Natasha, Elkhashab, Magdy, Fraser, Hughie, Kaita, Kelly, Ma, Mang, Marotta, Paul, Ramji, Alnoor, Tam, Edward, Yoshida, Eric, Swain, Mark, Sebastiani, Giada, Petrunia, Denis, Abergel, Armando, Anty, Rodolphe, Bourlière, Marc, Boursier, Jérôme, Bureau, Christophe, Castera, Laurent, Habersetzer, François, Hézode, Christophe, Ledinghen, Victor De, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Pol, Stanislas, Zoulim, Fabien, Hinrichsen, Holger, Ingiliz, Patrick, Lammert, Frank, Manns, Michael, Schattenberg, Jörn, Schiefke, Ingolf, Trautwein, Christian, Zeuzem, Stefan, Hui, Aric, Li, King-Kong, Wong, Vincent, Acharya, Subrat, Chowdhury, Abhijit, Duseja, Ajay, Kapoor, Dharmesh, Mukewar, Shrikant, Sarin, Shiv, Shah, Samir, Shalimar, Sood, Ajit, Tantry, BV, Ben-Ari, Ziv, Katchman, Helena, Safadi, Rifaat, Veitsman, Ella, Zuckerman, Eli, Brunetto, Maurizia, Lampertico, Pietro, Mangia, Alessandra, Akahane, Takemi, Akuta, Norio, Eguchi, Yuichiro, Fujiyama, Shigetoshi, Genda, Takuya, Hiasa, Yoichi, Ido, Akio, Ikeda, Fusao, Ikegami, Tadashi, Imajo, Kento, Itoh, Yoshito, Iwasa, Motoh, Karino, Yoshiyasu, Kato, Naoya, Kawaguchi, Takumi, Kawanaka, Miwa, Kido, Masahiro, Kobayashi, Tomoo, Kurosaki, Masayuki, Matsuzaki, Yasushi, Mita, Eiji, Mizukoshi, Eishiro, Nakahara, Takashi, Nomura, Hideyuki, Notsumata, Kazuo, Okanoue, Takeshi, Saito, Satoshi, Sakugawa, Hiroshi, Suzuki, Yoshiyuki, Takaguchi, Koichi, Takaki, Akinobu, Takashima, Tomoyuki, Tanaka, Saiyu, Tsuji, Keiji, Ueno, Yoshiyuki, Umemura, Takeji, Uto, Hirofumi, Yamashita, Nobuyuki, Yanase, Mikio, Yatsuhashi, Hiroshi, Yoneda, Masashi, Chan, Wah Kheong, Tan, Soek Siam, Garza, Laura Cisneros, Ladron De Guevara Cetina, Alma, Angeles, Rocio Guadalupe Vargas, Silva, Francisca Martinez, Van Erpecum, Karel, Orr, David, Jabłkowski, Maciej, Jaroszewicz, Jerzy, Ramos, Jose, Ahmed, Taufique, Ang, Tiing, Dan, Yock young, Goh, Boon Bee, Kaliyaperumal, Kalaiyarasi, Yip, Cherng Hann, Baik, Soon Koo, Jang, Byoung Kuk, Jun, Dae Won, Kim, Won, Kim, Hyung Joon, Kim, Ji Hoon, Lee, Kwan Sik, Lee, Chun Kyon, Lim, Young-Suk, Park, Jun Yong, Tak, Won Young, Augustin, Salvador, Perez, Salvador Benlloch, Caballeria, Juan, Luis, Jose, Panero, Calleja, Rodríguez, Jose Carrión, Garcia, Javier Crespo, Samaniego, Javier Garcia, Gibert, Pere Ginès, Prieto, Martin, Gomez, Manuel Romero, Turnes, Juan, Dufour, Jean-Francois, Moriggia, Alberto, Sheen, I-Shyan, Kao, Jia-Horng, Cheng, Pin-Nan, Huang, Jee-Fu, Yang, Sheng-Shun, Su, Wei-Wen, Chen, Chi-Yi, Chien, Rong-Nan, Lo, Gin-Ho, Chu, Chi-Jen, Wang, Horng-Yuan, Hu, Jui-Ting, Huang, Yi Wen, Agarwal, Kosh, Allison, Michael, Anstee, Quentin, Austin, Andrew, Fowell, Andrew, Ch'ng, Chin Lye, Manousou, Pinelopi, Newsome, Philip, Ryder, Stephen, Shankar, Arun, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Alam, Imtiaz, Alba, Laura, Alkhouri, Naim, Allen, Alina, Aqel, Bashar, Balart, Luis, Barritt, A. Sidney, IV, Behari, Jaideep, Bennett, Michael, Bernstein, David, Bhandari, Bal Raj, Bonacini, Maurizio, Borg, Brian, Brown, Kimberly, Bzowej, Natalie, Caldwell, Stephen, Chami, Tawfik, Coates, Allan, Cueli, Adolfo, Davis, Mitchell, deLemos, Andrew, Desai, Archita, Dunn, Winston, Ferreira, Nelson, Fine, Michael, Firpi-Morell, Roberto, Freedland, Curtis, Freilich, Bradley, Fuchs, Michael, Galambos, Michael, Gallegos-Orozco, Juan, Galler, Greg, Ghali, Maged, Ghalib, Reem, Gill, Satinder, Gillis, Marcum, Gilroy, Richard, Gordon, Stuart, Gunn, Nadege, Halegoua-DeMarzio, Dina, Hassan, Mohamed, Hassanein, Tarek, Herring, Robert, Jr., Hong, John, Huang, Jonathan, Kabler, Heidi, Kayali, Zeid, Knapple, Whitfield, Kolli, Geetha, Kowdley, Kris, Krause, Richard, Lawitz, Eric, Lidofsky, Steven, Lim, Joseph, Lipkis, Donald, Loomba, Rohit, Mahgoub, Amar, Malespin, Miguel, Manch, Richard, Mannis, Steven, Manos, Paul, McDonald, Thomas, McKenzie, Mark, Mena, Edward, Merriman, Raphael, Moehlen, Martin William, Montgomery, Richard, Murphy, Robert, Natarajan, Yamini, Neff, Guy, Noureddin, Mazen, Ortiz-Lasanta, Grisell, Pagadala, Mangesh, Patel, Keyur, Patton, Heather, Peyton, Adam, Pimstone, Neville, Poulos, John, Pound, David, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ravendhran, Natarajan, Ravinuthala, Ravi, Reddy, K. Rajendar, Reindollar, Robert, Reynolds, Justin, Rinella, Mary, Rizvi, Syed, Rockey, Don, Rodriguez-Perez, Federico, Ruane, Peter, Rubin, Raymond, Ryan, Michael, Saeian, Kia, Sanyal, Arun, Sarkar, Souvik, Scanga, Andrew, Schiff, Eugene, Schmidt, Warren, Schneider, Jeffrey, Sepe, Thomas, Shah, Dhiren, Shaikh, Obaid, Shankar, Uday, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shiffman, Mitchell, Siddique, Asma, Smith, Matthew, Suarez, Rosa, Talal, Andrew, Te, Helen, Tekola, Bezawit, Tetri, Brent, Thuluvath, Paul, Toro, Doris, Torres, Dawn, Trinh, Huy, Trotter, James, Vento, Angel, Vierling, John, Vuppalanchi, Raj, Waters, Michael, Weisberg, Ilan, Wieland, Amanda, Williams, Alonzo, Younes, Ziad, Adams, Leon, Harding, Damian, Hodge, Alex, Kontorinis, Nick, Strasser, Simone, Thompson, Alex, Horsmans, Yves, Steenkiste, Christophe Van, Bailey, Robert, Giard, Jeanne-Marie, Montano-Loza, Aldo, Puglia, Marco, Tsoi, Keith, Larrey, Dominique, Nguyen-Khac, Eric, Ratziu, Vlad, Spengler, Ulrich, Wiegand, Johannes, Hui, Aric Josun, Acharya, Subrat Kumar, Sarin, Shiv Kumar, Tantry, Vishwanath, Braun, Marius, Hazzan, Rawi, Lurie, Yoav, Colombo, Massimo, Fujii, Hideki, Hashimoto, Etsuko, Kato, Masaki, Ogawa, Koji, Takehara, Tetsuo, Tokushige, Katsutoshi, Garza, Laura Esthela Cisneros, Ladrón De Guevara, Alma Laura, Schultz, Michael, Janczewska, Ewa, Toro, Doris H., Jeong, Sook-Hyang, Kim, Yoon Jun, Lee, Jin-Woo, Ang, Tiing Leong, Bee, George Goh Boon, Benlloch, Salvador, Caballería, Juan, Calleja, José Luis, Rodríguez, Jose A. Carrión, Crespo, Javier, Diago, Moises, Fernandez-Rodriguez, Conrado, García-Samaniego, Javier, Ginès, Pere, Romero, Manuel, Dufour, Jean-François, Alazawi, William, Ch'ng, Chin-Lye, Forton, Daniel, Priest, Matthew, Sheridan, David, Ankoma-Sey, Victor, Balakrishnan, Maya, Bambha, Kiran, Barritt, A. Sidney, Bhandari, Bal, Brandman, Danielle, Chang, Charissa, Corey, Kathleen, Feldman, Michael, Gholam, Pierre, Goff, John, Marzio, Dina Halegoua-De, Harrison, Stephen, Hellstern, Paul, Jr., Herring, Robert, Iyer, Rajalakshmi, Jakiche, Antoine, Kohli, Anita, Krok, Karen, Kugelmas, Marcelo, Kumar, Sonal, Lai, Michelle, Mahmoud, Mitchell, Mantry, Parvez, Marsano, Luis, Nguyen, Tuan, Park, James, Patton, Heather M., Pockros, Paul, Reddy, Rajender, Rodriguez, Miguel, Sarles, Harry, Satapathy, Sanjaya, Sedghi, Shahriar, Shah, Nikunj, Sheikh, Muhammad Yasin, Sigal, Samuel, Stanca, Carmen, Steinbook, Michael, Szabo, Gyongyi, Terrault, Norah, Tong, Myron, Victor, David, Zervos, Xaralambos, Harrison, Stephen A., Wong, Vincent Wai-Sun, Caldwell, Stephen H., Shiffman, Mitchell L., Camargo, Marianne, Li, Georgia, Kersey, Kathryn, Jia, Catherine, Zhu, Yanni, Djedjos, C. Stephen, Subramanian, G. Mani, Myers, Robert P., Anstee, Quentin M., Romero-Gomez, Manuel, Goodman, Zachary, Lawitz, Eric J., and Younossi, Zobair

Published
2020
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6. Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals

Author

Antoni, C., Vogelmann, R., Ebert, M., Backhus, J., Seufferlein, T., Balavoine, J., Giostra, E., Berg, C., Cornberg, M., Wedemeyer, H., Manns, M., De Gottardi, A., Esteban, R., Discher, T., Roeb, E., Gress, M., Günther, R., Wietzke-Braun, P., Herrmann, A., Stallmach, A., Hoffmann, D., Klinker, H., Kodal, A., Lammert, F., Löbermann, M., Schulze zur Wiesch, J., von Felden, J., Piecha, F., Lohse, A., Götze, T., Malfertheiner, P., Mayerle, J., Moradpour, D., Moreno, C., Neumann-Haefelin, C., Thimme, R., Reinhardt, L., Ellenrieder, V., Schattenberg, J., Sprinzl, M., Galle, P., Schmidt, J., Schott, E., Epple, H.-J., Siebler, J., Stauber, R., Steckstor, M., Schmiegel, W., Stremmel, W., Strey, B., Tomasiewicz, K., Trautwein, C., Zachoval, R., Angeli, W., Beckebaum, S., Doberauer, C., Ende, K., Erhardt, A., Garrido-Lüneburg, A., Gattringer, H., Genné, D., Gschwantler, M., Gundling, F., Hartmann, C., Heyer, T., Hirschi, C., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Magenta, L., Terziroli Beretta-Piccoli, B., Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Piso, R., Rambach, W., Reiser, M., Riecken, B., Roth, J., Schöfl, R., Maieron, A., Schneider, A., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Semela, D., Stich, A., Vollmer, C., Brückner, J., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Audebert, F., Baermann, C., Bästlein, E., Barth, R., Barthel, K., Baumgartl, K., Becker, W., Benninger, J., Beyer, T., Bodtländer, A., Böhm, G., Bohr, U., Moll, A., Naumann, U., Börner, N., Bruch, H.R., Busch, N., Burkhard, O., Chirca, C., Dienethal, A., Dietel, P., Dreher, F., Efken, P., Ehrle, U., Emke, F., Fischer, J., Fischer, U., Frederking, D., Frick, B., Gantke B, B., Geyer, P., Glaunsinger, T., Goebel, F., Göbel, U., Graf, R., Herder, M., Heuchel, T., Heuer, S., Heyne, R., Höffl, K.H., Hofmann, W.P., Holst, F., Hörster, H., John, C., Jung, M.C., Kallinowski, B., Kerzel, W., Khaykin, P., Klarhof, M., Knapp, B., Knevels, U., Körfer, A., Köster, A., Künzig, B., Langenkamp, A., Kuhn, M., Littman, M., Löhr, H., Ludwig, L., Lutz, U., Maurer, P., Mayer, C., Meister, V., Moritzen, D., Mroß, M., Mundlos, M., Nehls, O., Ningel, K., Oelmann, A., Olejnik, H., Pascher, E., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rump, A., Schmidt, W., Schmidtler-von Fabris, J., Schneider, L., Schober, A., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K., Stähler, D., Steffens, H., Svensson, K., Tacke, W., Teubner, K., Thieringer, J., Trappe, U., Ullrich, J., Usadel, S., von Lucadou, A., Werheid-Dobers, M., Zehnter, E., Zipf, A., Dietz, Julia, Susser, Simone, Vermehren, Johannes, Peiffer, Kai-Henrik, Grammatikos, Georgios, Berger, Annemarie, Ferenci, Peter, Buti, Maria, Müllhaupt, Beat, Hunyady, Bela, Hinrichsen, Holger, Mauss, Stefan, Petersen, Jörg, Buggisch, Peter, Felten, Gisela, Hüppe, Dietrich, Knecht, Gaby, Lutz, Thomas, Schott, Eckart, Berg, Christoph, Spengler, Ulrich, von Hahn, Thomas, Berg, Thomas, Zeuzem, Stefan, and Sarrazin, Christoph

Published
2018
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8. Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open-label, multicentre phase 3 trial

Author

Forns, Xavier, Lee, Samuel S, Valdes, Joaquin, Lens, Sabela, Ghalib, Reem, Aguilar, Humberto, Felizarta, Franco, Hassanein, Tarek, Hinrichsen, Holger, Rincon, Diego, Morillas, Rosa, Zeuzem, Stefan, Horsmans, Yves, Nelson, David R, Yu, Yao, Krishnan, Preethi, Lin, Chih-Wei, Kort, Jens J, and Mensa, Federico J

Published
2017
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10. Increasing functional cure rate beyond 96 weeks after discontinuation of nucleos (t)ide analogue treatment in HBeAg-negative chronic hepatitis B: follow-up of the stop-NUC trial

Author

van Bömmel, Florian, primary, Stein, Kerstin, additional, Heyne, Renate, additional, Petersen, Jörg, additional, Buggisch, Peter, additional, Berg, Christoph, additional, Zeuzem, Stefan, additional, Stallmach, Andreas, additional, Sprinzl, Martin, additional, Schott, Eckart, additional, Pathil-Warth, Anita, additional, von Arnim, Ulrike, additional, Keitel, Verena, additional, Lohmeyer, Jürgen, additional, Georg, Simon Karl, additional, Trautwein, Christian, additional, Trein, Andreas, additional, Hüppe, Dietrich, additional, Cornberg, Markus, additional, Lammert, Frank, additional, Ingiliz, Patrick, additional, Zachoval, Reinhart, additional, Hinrichsen, Holger, additional, Zipprich, Alexander, additional, Klinker, Hartwig, additional, zur Wiesch, Julian Schulze, additional, Schmiedeknecht, Anett, additional, Brosteanu, Oana, additional, and Berg, Thomas, additional

Published
2023
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11. A phase 3, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of cilofexor in patients with non-cirrhotic primary sclerosing cholangitis (PRIMIS)

Author

Trauner, Michael, primary, Levy, Cynthia, additional, Tanaka, Atsushi, additional, Goodman, Zachary, additional, Thorburn, Douglas, additional, Joshi, Deepak, additional, Salminen, Kimmo, additional, Yimam, Kidist, additional, Isayama, Hiroyuki, additional, Montano-Loza, Aldo J, additional, Danta, Mark, additional, Hinrichsen, Holger, additional, Invernizzi, Pietro, additional, Liu, Xiangyu, additional, Lu, Xiaomin, additional, Alani, Muhsen, additional, Barchuk, William, additional, Watkins, Timothy R., additional, Genovese, Mark, additional, and Bowlus, Christopher, additional

Published
2023
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13. Antiviral Therapy of Chronic Hepatitis D Virus Infection – Addendum to the S3 Guideline "Prophylaxis, Diagnosis and Therapy of Hepatitis B Virus Infection" of the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS) 1.

Author

Sandmann, Lisa, Berg, Thomas, Deterding, Katja, Fischer, Nadine, Hinrichsen, Holger, Petersen, Jörg, Tacke, Frank, Cornberg, Markus, BergChristophvan BömmelFlorianBuggischPeterChristensenStefanCiesekSandraDikopoulosNektariosFlemmingGunterGlebeDieterHöner zu SiederdissenChristophIngilizPatrickJochumChristophKlinkerHartwigde ..AUR-Author, Berg, Christoph, van Bömmel, Florian, Buggisch, Peter, Christensen, Stefan, Ciesek, Sandra, Dikopoulos, Nektarios, Flemming, Gunter, Glebe, Dieter, Höner zu Siederdissen, Christoph, Ingiliz, Patrick, and Jochum, Christoph

Published
2023
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14. Addendum „Antivirale Therapie der chronischen Hepatitis-D-Virusinfektion" zur S3-Leitlinie „Prophylaxe, Diagnostik und Therapie der Hepatitis-B-Virusinfektion" der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) 1

Author

Sandmann, Lisa, Berg, Thomas, Deterding, Katja, Fischer, Nadine, Hinrichsen, Holger, Petersen, Jörg, Tacke, Frank, Cornberg, Markus, BergChristophvan BömmelFlorianBuggischPeterChristensenStefanCiesekSandraDikopoulosNektariosFlemmingGunterGlebeDieterzu SiederdissenChristoph HönerIngilizPatrickJochumChristophKlinkerHartwigde, Berg, Christoph, van Bömmel, Florian, Buggisch, Peter, Christensen, Stefan, Ciesek, Sandra, Dikopoulos, Nektarios, Flemming, Gunter, Glebe, Dieter, zu Siederdissen, Christoph Höner, Ingiliz, Patrick, and Jochum, Christoph

Published
2023
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16. Delayed versus immediate treatment for patients with acute hepatitis C: a randomised controlled non-inferiority trial

Author

Deterding, Katja, Grüner, Norbert, Buggisch, Peter, Wiegand, Johannes, Galle, Peter R, Spengler, Ulrich, Hinrichsen, Holger, Berg, Thomas, Potthoff, Andrej, Malek, Nisar, Großhennig, Anika, Koch, Armin, Diepolder, Helmut, Lüth, Stefan, Feyerabend, Sandra, Jung, Maria Christina, Rogalska-Taranta, Magdalena, Schlaphoff, Verena, Cornberg, Markus, Manns, Michael P, and Wedemeyer, Heiner

Published
2013
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17. Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection

Author

Fischer, Janett, Weber, Alexander N R, Böhm, Stephan, Dickhöfer, Sabine, El Maadidi, Souhayla, Deichsel, Danilo, Knop, Viola, Klinker, Hartwig, Möller, Bernd, Rasenack, Jens, Wang, Lisa, Sharma, Manu, Hinrichsen, Holger, Spengler, Ulrich, Buggisch, Peter, Sarrazin, Christoph, Pawlita, Michael, Waterboer, Tim, Wiese, Manfred, Probst-Müller, Elsbeth, Malinverni, Raffaele, Bochud, Pierre-Yves, Gardiner, Clair, OʼFarrelly, Cliona, and Berg, Thomas

Published
2017
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19. Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of Differences Between Alcohol-Related and Non-Alcohol-Related Cirrhosis Candidates

Author

Gundlach, Jan-Paul, primary, Braun, Felix, additional, Mötter, Finn, additional, Bernsmeier, Alexander, additional, Barrio, Pablo, additional, Ehmke, Nicola, additional, Günther, Rainer, additional, Hinrichsen, Holger, additional, Becker, Thomas, additional, Weinmann, Wolfgang, additional, Schröck, Alexandra, additional, Yegles, Michel, additional, and Wurst, Friedrich Martin, additional

Published
2022
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23. Reduced dose and duration of peginterferon alfa-2b and weight-based ribavirin in patients with genotype 2 and 3 chronic hepatitis C

Author

Manns, Michael, Zeuzem, Stefan, Sood, Ajit, Lurie, Yoav, Cornberg, Markus, Klinker, Hartwig, Buggisch, Peter, Rössle, Martin, Hinrichsen, Holger, Merican, Ismail, Ilan, Yaron, Mauss, Stefan, Abu-Mouch, Saif, Horban, Andryes, Müller, Thomas H., Welsch, Christoph, Chen, Rongdean, Faruqi, Rab, Pedicone, Lisa D., and Wedemeyer, Heiner

Published
2011
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24. Randomised clinical trial: alisporivir combined with peginterferon and ribavirin in treatment-naïve patients with chronic HCV genotype 1 infection (ESSENTIAL II)

Author

Zeuzem, S., Flisiak, R., Vierling, J. M., Mazur, W., Mazzella, G., Thongsawat, S., Abdurakhmanov, D., Van Kính, N., Calistru, P., Heo, J., Stanciu, C., Gould, M., Makara, M., Hsu, S.-J., Buggisch, P., Samuel, D., Mutimer, D., Nault, B., Merz, M., Bao, W., Griffel, L. H., Brass, C., Naoumov, N. V., Tanno, Hugo, Bessone, Fernando, Terg, Ruben, Frider, Bernardo, Bertuzzi, Romina, Desmond, Paul, Zekry, Amany, Weltman, Martin, George, Jacob, Crawford, Darrell, Matthews, Gail, Moreno, Christophe, Van Vlierberghe, Hans, Reynaert, Hendrik, Gould, Michael, Lee, Samuel, Ramji, Alnoor, Tam, Edward, Marotta, Paul, Yoshida, Eric, Wong, Florence, Feld, Jordan, Samuel, Didier, Marcellin, Patrick, Alric, Laurent, Zarski, Jean-Pierre, Zoulim, Fabien, Buggisch, Peter, Hinrichsen, Holger, Goeser, Tobias, Zeuzem, Stefan, Galle, Peter, Berg, Thomas, Schott, Eckart, Rasenack, Jens, Gerken, Guido, Wedemeyer, Hans, Tsang, Owen, Yuen, Man-Fung, Chan, Henry, Hui, Aric Josun, Makara, Mihaly, Tornai, Istvan, Gervain, Judit, Szalay, Ferenc, Varga, Marta, Horvath, Gabor, Hunyady, Bela, Vincze, Aron, Mazzella, Giuseppe, Gaeta, Giovanni Battista, Alberti, Alfredo, Colombo, Massimo, Andreone, Pietro, Rizzetto, Mario, Angelico, Mario, Craxi, Antonio, Picciotto, Antonino, Sacchi, Paolo, Vinci, Maria, Invernizzi, Pietro, Bruno, Savino, Heo, Jeong, Lee, Younjae, Cho, Mong, Han, Sangyoung, Lee, Jinwoo, Ahn, Sanghoon, Lim, Youngsuk, Hwang, Seonggyu, Sanchez, Juan, Muñoz, Linda, Maldonado, Hector, Mazur, Wlodzimierz, Flisiak, Robert, Jablkowski, Maciej, Kryczka, Wieslaw, Halota, Waldemar, Calistru, Petre, Prelipcean, Cristina, Musa, Manuela, Stanciu, Carol, Manuc, Mircea, Tanasescu, Coman, Dumitrascu, Dan, Abdurakhmanov, Djamal, Chulanov, Vladimir, Nikitin, Igor, Zhdanov, Konstantin, Esaulenko, Elena, Maevskaya, Marina, Znoyko, Olga, Lamoglia, Ricard Sola, Ferret, Maria Buti, Garcia-Samaniego, Javier, Gomez, Manuel Romero, Diago, Moises, Calleja, Jose Luis, Hsu, Shih-Jer, Chuang, Wan-Long, Hu, Tsung-Hui, Peng, Cheng-Yuan, Chen, Chi-Yi, Kao, Jia-Horng, Thongsawat, Satawat, Sukeepaisarnjaroen, Wattana, Piratvisuth, Teerha, Tanwandee, Tawesak, Komolmit, Piyawat, Agarwal, Kosh, Mutimer, David, Brown, Ashley, Foster, Graham, McPherson, Stuart, Ryder, Stephen, Poulos, John, Rustgi, Vinod, Lyche, Kip, Omarro, Steven, Vierling, John, Ghalib, Reem, Karnam, Umaprasanna, Peine, Craig, Galati, Joseph, Person, John, De La Torre, Andrew, Ravendhran, Natarajan, Mushahwar, Andria, OʼLeary, Jacqueline, Lee, William, Lawitz, Eric, Ankoma-Sey, Victor, King, John, Pound, David, Scarsella, Anthony, Thuluvath, Paul, Pockros, Paul, Mailliard, Mark, Shiffman, Mitchell, Sylvestre, Diana, Heiman, David, Jacobson, Ira, Bacon, Bruce, Dimitroff, James, Reindollar, Robert, Tobias, Hillel, Godofsky, Eliot, Rodriguez-Torres, Maribel, Bennett, Michael, Ben-Zvi, Jeffrey, Van, Kinh Nguyen, Dao, Long, Huu, Hoang Bui, Minh, Yen Lam, Le Thanh, Ly, and Van Long, Dao

Published
2015
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30. Metabolomic tissue signature in human non-alcoholic fatty liver disease identifies protective candidate metabolites

Author

von Schönfels, Witigo, Patsenker, Eleonora, Fahrner, René, Itzel, Timo, Hinrichsen, Holger, Brosch, Mario, Erhart, Wiebke, Gruodyte, Auste, Vollnberg, Bernd, Richter, Klaus, Landrock, Andreas, Schreiber, Stefan, Brückner, Stephan, Beldi, Guido, Sipos, Bence, Becker, Thomas, Röcken, Christoph, Teufel, Andreas, Stickel, Felix, Schafmayer, Clemens, and Hampe, Jochen

Published
2015
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31. Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis

Author

Stickel, Felix, Buch, Stephan, Zoller, Heinz, Hultcrantz, Rolf, Gallati, Sabina, Österreicher, Christoph, Finkenstedt, Armin, Stadlmayr, Andreas, Aigner, Elmar, Sahinbegovic, Enijad, Sarrazin, Christoph, Schafmayer, Clemens, Braun, Felix, Erhart, Wiebke, Nothnagel, Michael, Lerch, Markus M., Mayerle, Julia, Völzke, Henry, Schaller, André, Kratzer, Wolfgang, Boehm, Bernhard O., Sipos, Bence, DʼAmato, Mauro, Torkvist, Leif, Stal, Per, Arlt, Alexander, Franke, Andre, Becker, Thomas, Krawczak, Michael, Zwerina, Jochen, Berg, Thomas, Hinrichsen, Holger, Krones, Elisabeth, Dejaco, Christian, Strasser, Michael, Datz, Christian, and Hampe, Jochen

Published
2014
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33. Barriers to initiation of hepatitis C virus therapy in Germany: A retrospective, case-controlled study

Author

Buggisch, Peter, primary, Heiken, Hans, additional, Mauss, Stefan, additional, Weber, Bernd, additional, Jung, Maria-Christina, additional, Görne, Herbert, additional, Heyne, Renate, additional, Hinrichsen, Holger, additional, Hidde, Dennis, additional, König, Bettina, additional, Pires dos Santos, Ana Gabriela, additional, Niederau, Claus, additional, and Berg, Thomas, additional

Published
2021
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35. Real-Life Experiences with Telaprevir in the Treatment of Chronic Genotype 1 Hepatitis C — The TEPS Study

Author

Berg, Thomas, Buggisch, Peter, Hüppe, Dietrich, Mauss, Stefan, Wedemeyer, Heiner, Teuber, Gerlinde, Lutz, Thomas, Stein, Kerstin, Wegner, Sven, and Hinrichsen, Holger

Subjects
medicine.medical_specialty, shortening of treatment, RC799-869, Telaprevir, Virological response, Therapy naive, Internal medicine, Medicine, media_common.cataloged_instance, Protease inhibitor (pharmacology), In patient, ddc:610, European union, hepatitis c, General Environmental Science, media_common, business.industry, stopping rule, Stopping rule, Hepatitis C, Diseases of the digestive system. Gastroenterology, medicine.disease, sustained virological response (svr), General Earth and Planetary Sciences, business, direct acting antivirals (daa), medicine.drug
Abstract

As one of the first Direct Acting Antivirals (DAA), the protease inhibitor Telaprevir (TVR) was available in the European Union from 9/2011 until 9/2016 as a new treatment option for chronic Hepatitis C.Aim. To assess the implementation of therapy stopping rules or shortening of the treatment and their impact on sustained virological response (SVR), as well as the safety and efficacy of the TVR-based therapy during routine daily treatment of patients in Germany.Materials and Methods. 802 patients were assessed (272 treatment naïve, 520 pre-treated) in the noninterventional, multi-center study.Results. 56.6 % of the patients achieved SVR. SVR rate was higher in patients with relapse after previous treatment (68.0 %) than in patients with a previous null-response (31.1 %) and in previously untreated patients (58.1 %). Stopping rule conditions were fulfilled by 3.2 % of patients and it was implemented in 65.4 % of these. 34.3 % of the patients fulfilled the conditions for a therapy shortening. This rule was adhered to in 48.4 % of these, in 34.5 % it was not adhered to. Thus recommendations were not always being followed. Therapy shortening was considered more frequently in previously untreated (54.8 %) than for previously treated patients (24.2 %). Stopping rule application but not shortened treatment reduced therapy costs.Conclusion. The TVR-based therapy represented a breakthrough at that time. Further DAAs have been added as therapeutic options since, increasing the complexity of treatment choice and correct implementation. They represent both an opportunity and a challenge for all those involved.As one of the first Direct Acting Antivirals (DAA), the protease inhibitor Telaprevir (TVR) was available in the European Union from 9/2011 until 9/2016 as a new treatment option for chronic Hepatitis C.Aim. To assess the implementation of therapy stopping rules or shortening of the treatment and their impact on sustained virological response (SVR), as well as the safety and efficacy of the TVR-based therapy during routine daily treatment of patients in Germany.Materials and Methods. 802 patients were assessed (272 treatment naïve, 520 pre-treated) in the noninterventional, multi-center study.Results. 56.6 % of the patients achieved SVR. SVR rate was higher in patients with relapse after previous treatment (68.0 %) than in patients with a previous null-response (31.1 %) and in previously untreated patients (58.1 %). Stopping rule conditions were fulfilled by 3.2 % of patients and it was implemented in 65.4 % of these. 34.3 % of the patients fulfilled the conditions for a therapy shortening. This rule was adhered to in 48.4 % of these, in 34.5 % it was not adhered to. Thus recommendations were not always being followed. Therapy shortening was considered more frequently in previously untreated (54.8 %) than for previously treated patients (24.2 %). Stopping rule application but not shortened treatment reduced therapy costs.Conclusion. The TVR-based therapy represented a breakthrough at that time. Further DAAs have been added as therapeutic options since, increasing the complexity of treatment choice and correct implementation. They represent both an opportunity and a challenge for all those involved. Ингибитор протеазы Телапревир (ТПВ) является одним из первых противовирусных препаратов прямого действия (ПППД) и применялся в странах Евросоюза при лечении хронического гепатита С в качестве нового метода с сентября 2011 года по сентябрь 2016 года. Цель: Оценить применение правил остановки (прекращения) или сокращения периода терапии и их влияние на устойчивый вирусологический ответ (УВО), а также безопасность и эффективность противовирусной терапии на основе ТПВ при рутинном применении в Германии. Материалы и методы. В неинтервенционном мультицентровом исследовании участвовали 802 пациента (272 пациента, ранее не получавшие, и 520 пациентов, ранее получавшие противовирусные препараты). Результаты. Устойчивый вирусологический ответ (УВО) был достигнут у 56,6 % пациентов. Доля пациентов с УВО среди пациентов с рецидивом после предыдущего лечения была выше (68,0 %), чем у пациентов с предыдущим нулевым ответом (31,1 %) и у пациентов, ранее не получавших противовирусные препараты (58,1 %). Критериям прекращения терапии соответствовали 3,2 % пациентов, из них у 65,4 % лечение было остановлено. Критериям сокращения терапии соответствовали 34,3 % пациентов. Это правило было применено в отношении 48,4 % из них, у 34,5 % оно не соблюдалось. Таким образом, не всегда соблюдались рекомендации по прекращению или сокращению терапии. Чаще терапию сокращали в группе пациентов, ранее не получавших лечения (54,8%), чем в группе пациентов, получавших противовирусную терапию в анамнезе (24,2%). Именно применение правил прекращения терапии, а не сокращение ее продолжительности, позволило снизить затраты на лечение. Заключение. Терапия на основе ТПВ в свое время стала прорывом в лечении гепатита С. Позже были предложены новые варианты ПППД для терапии, что усложнило выбор и точность применения препаратов. ПППД привнесли одновременно как новые возможности, так и новые сложности.

Published
2019

36. Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1-3 Infections

Author

Dietz, Julia, Spengler, Ulrich, Mullhaupt, Beat, zur Wiesch, Julian Schulze, Piecha, Felix, Mauss, Stefan, Seegers, Barbara, Hinrichsen, Holger, Antoni, Christoph, Wietzke-Braun, Perdita, Peiffer, Kai-Henrik, Berger, Annemarie, Matschenz, Katrin, Buggisch, Peter, Backhus, Johanna, Zizer, Eugen, Boettler, Tobias, Neumann-Haefelin, Christoph, Semela, David, Stauber, Rudolf, Berg, Thomas, Berg, Christoph, Zeuzem, Stefan, Vermehren, Johannes, Sarrazin, Christoph, Balavoine, J., Giostra, E., Berning, M., Hampe, J., De Gottardi, A., Rauch, A., Semmo, N., Discher, T., Trauth, J., Fischer, J., Gress, M., Guenther, R., Heinzow, H., Schmidt, J., Herrmann, A., Stallmach, A., Hilgard, G., Deterding, K., Lange, C. M., Ciesek, S., Wedemeyer, H., Hoffmann, D., Klinker, H., Schulze, P., Kocheise, F., Mueller-Schilling, M., Kodal, A., Kremer, A., Ganslmayer, M., Siebler, J., Lammert, F., Rissland, J., Loebermann, M., Goetze, T., Canbay, A., Lohse, A., von Felden, J., Jordan, S., Maieron, A., Moradpour, D., Chave, J. -P., Moreno, C., Mueller, T., Muche, M., Epple, H. -J., Port, K., von Hahn, T., Cornberg, M., Manns, M., Reinhardt, L., Ellenrieder, V., Rockstroh, J., Schattenberg, J., Sprinzl, M., Galle, P., Roeb, E., Steckstor, M., Schmiegel, W., Brockmeyer, N. H., Seufferlein, T., Stremmel, W., Strey, B., Thimme, R., Teufel, A., Vogelmann, R., Ebert, M., Tomasiewicz, K., Trautwein, C., Tacke, F., Koenen, T., Weber, T., Zachoval, R., Mayerle, J., Raziorrouh, B., Angeli, W., Beckebaum, S., Doberauer, C., Durmashkina, E., Hackelsberger, A., Erhardt, A., Garrido-Luneburg, A., Gattringer, H., Genne, D., Gschwantler, M., Gundling, F., Hametner, S., Schofl, R., Hartmann, C., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschlager, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Baermann, C., Bastlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtlander, A., Bohm, G., Borner, N., Bohr, U., Bokemeyer, B., Bruch, H. R., Bucholz, D., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Huppe, D., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H. R., Glas, M., Glaunsinger, T., Goebel, F., Gobel, U., Gorlitz, B., Graf, R., Gruber, H., Harter, G., Herder, M., Heuchel, T., Heuer, S., Hoffl, K. -H., Horster, H., Sonne, J. -U., Hofmann, W. P., Holst, F., Hunstiger, M., Hurst, A., Jagel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Kluppelberg, U., Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Korfer, A., Koster, A., Kuhn, M., Langekamp, A., Kunzig, B., Link, R., Littman, M., Lohr, H., Lutz, T., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mayer, C., Meister, V., Moller, H., Heyne, R., Moritzen, D., Mross, M., Mundlos, M., Naumann, U., Nehls, O., Ningel, R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Petersen, J., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rossle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, K. J., Schmidt, W., Schmidt-Heinevetter, G., Schmidtler-von Fabris, J., Schnaitmann, E., Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K. G., Stahler, D., Stenschke, F., Steffens, H., Stein, K., Steinmuller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., Zipf, A., Dietz, Julia, Spengler, Ulrich, Mullhaupt, Beat, zur Wiesch, Julian Schulze, Piecha, Felix, Mauss, Stefan, Seegers, Barbara, Hinrichsen, Holger, Antoni, Christoph, Wietzke-Braun, Perdita, Peiffer, Kai-Henrik, Berger, Annemarie, Matschenz, Katrin, Buggisch, Peter, Backhus, Johanna, Zizer, Eugen, Boettler, Tobias, Neumann-Haefelin, Christoph, Semela, David, Stauber, Rudolf, Berg, Thomas, Berg, Christoph, Zeuzem, Stefan, Vermehren, Johannes, Sarrazin, Christoph, Balavoine, J., Giostra, E., Berning, M., Hampe, J., De Gottardi, A., Rauch, A., Semmo, N., Discher, T., Trauth, J., Fischer, J., Gress, M., Guenther, R., Heinzow, H., Schmidt, J., Herrmann, A., Stallmach, A., Hilgard, G., Deterding, K., Lange, C. M., Ciesek, S., Wedemeyer, H., Hoffmann, D., Klinker, H., Schulze, P., Kocheise, F., Mueller-Schilling, M., Kodal, A., Kremer, A., Ganslmayer, M., Siebler, J., Lammert, F., Rissland, J., Loebermann, M., Goetze, T., Canbay, A., Lohse, A., von Felden, J., Jordan, S., Maieron, A., Moradpour, D., Chave, J. -P., Moreno, C., Mueller, T., Muche, M., Epple, H. -J., Port, K., von Hahn, T., Cornberg, M., Manns, M., Reinhardt, L., Ellenrieder, V., Rockstroh, J., Schattenberg, J., Sprinzl, M., Galle, P., Roeb, E., Steckstor, M., Schmiegel, W., Brockmeyer, N. H., Seufferlein, T., Stremmel, W., Strey, B., Thimme, R., Teufel, A., Vogelmann, R., Ebert, M., Tomasiewicz, K., Trautwein, C., Tacke, F., Koenen, T., Weber, T., Zachoval, R., Mayerle, J., Raziorrouh, B., Angeli, W., Beckebaum, S., Doberauer, C., Durmashkina, E., Hackelsberger, A., Erhardt, A., Garrido-Luneburg, A., Gattringer, H., Genne, D., Gschwantler, M., Gundling, F., Hametner, S., Schofl, R., Hartmann, C., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschlager, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Baermann, C., Bastlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtlander, A., Bohm, G., Borner, N., Bohr, U., Bokemeyer, B., Bruch, H. R., Bucholz, D., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Huppe, D., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H. R., Glas, M., Glaunsinger, T., Goebel, F., Gobel, U., Gorlitz, B., Graf, R., Gruber, H., Harter, G., Herder, M., Heuchel, T., Heuer, S., Hoffl, K. -H., Horster, H., Sonne, J. -U., Hofmann, W. P., Holst, F., Hunstiger, M., Hurst, A., Jagel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Kluppelberg, U., Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Korfer, A., Koster, A., Kuhn, M., Langekamp, A., Kunzig, B., Link, R., Littman, M., Lohr, H., Lutz, T., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mayer, C., Meister, V., Moller, H., Heyne, R., Moritzen, D., Mross, M., Mundlos, M., Naumann, U., Nehls, O., Ningel, R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Petersen, J., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rossle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, K. J., Schmidt, W., Schmidt-Heinevetter, G., Schmidtler-von Fabris, J., Schnaitmann, E., Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K. G., Stahler, D., Stenschke, F., Steffens, H., Stein, K., Steinmuller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., and Zipf, A.

Published
2021

37. Real-world clinical management of patients with primary biliary cholangitis - a retrospective multicenter study from Germany

Author

Wilde, Anne-Christin, Lieb, Charlotte, Leicht, Elise, Greverath, Lena Maria, Steinhagen, Lara Marleen, Wald de Chamorro, Nina, Petersen, Jörg, Hofmann, Wolf-Peter, Hinrichsen, Holger, Heyne, Renate, Berg, Thomas, Naumann, Uwe, Schwenzer, Jeannette, Vermehren, Johannes, Geier, Andreas, Tacke, Frank, Müller, Tobias, Wilde, Anne-Christin, Lieb, Charlotte, Leicht, Elise, Greverath, Lena Maria, Steinhagen, Lara Marleen, Wald de Chamorro, Nina, Petersen, Jörg, Hofmann, Wolf-Peter, Hinrichsen, Holger, Heyne, Renate, Berg, Thomas, Naumann, Uwe, Schwenzer, Jeannette, Vermehren, Johannes, Geier, Andreas, Tacke, Frank, and Müller, Tobias

Abstract

Background: Clinical practice guidelines for patients with primary biliary cholangitis (PBC) have been recently revised and implemented for well-established response criteria to standard first-line ursodeoxycholic acid (UDCA) therapy at 12 months after treatment initiation for the early identification of high-risk patients with inadequate treatment responses who may require treatment modification. However, there are only very limited data concerning the real-world clinical management of patients with PBC in Germany. Objective: The aim of this retrospective multicenter study was to evaluate response rates to standard first-line UDCA therapy and subsequent Second-line treatment regimens in a large cohort of well-characterized patients with PBC from 10 independent hepatological referral centers in Germany prior to the introduction of obeticholic acid as a licensed second-line treatment option. Methods: Diagnostic confirmation of PBC, standard first-line UDCA treatment regimens and response rates at 12 months according to Paris-I, Paris-II, and Barcelona criteria, the follow-up cut-off alkaline phosphatase (ALP) ≤ 1.67 × upper limit of normal (ULN) and the normalization of bilirubin (bilirubin ≤ 1 × ULN) were retrospectively examined between June 1986 and March 2017. The management and hitherto applied second-line treatment regimens in patients with an inadequate response to UDCA and subsequent response rates at 12 months were also evaluated. Results: Overall, 480 PBC patients were included in this study. The median UDCA dosage was 13.2 mg UDCA/kg bodyweight (BW)/d. Adequate UDCA treatment response rates according to Paris-I, Paris-II, and Barcelona criteria were observed in 91, 71.3, and 61.3% of patients, respectively. In 83.8% of patients, ALP ≤ 1.67 × ULN were achieved. A total of 116 patients (24.2%) showed an inadequate response to UDCA according to at least one criterion. The diverse second-line treatment regimens applied led to significantly higher response rate

Published
2021

38. Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry

Author

Dultz, Georg, Müller, Tobias, Petersen, Jörg, Mauss, Stefan, Zimmermann, Tim, Muche, Marion, Simon, Karl-Georg, Berg, Thomas, Zeuzem, Stefan, Hüppe, Dietrich, Böker, Klaus, Wedemeyer, Heiner, Welzel, Tania M., Günther, Rainer, Hinrichsen, Holger, Heyne, Renate, Roth, Johannes, Goeser, Tobias, Ullrich, Rainer, John, Christine, Hofmann, Wolf Peter, Teuber, Gerlinde, Möller, Hjördis, Baumgarten, Axel, Schwenzer, Jeannette, Pathil, Anita, Kraus, Michael R., Weber, Andreas, Jung, Maria-Christina, Gerken, Guido, Antoni, Christoph, Doss, Margareta Frank, Schober, Andreas, Hoffstadt, Martin, Lucadou, Armand v., Steffens, Hermann, Klinker, Hartwig, Geier, Andreas, Klausen, Gerd, Buggisch, Peter, Cornberg, Markus, Sarrazin, Christoph, Manns, Michael P., Niederau, Claus, Protzer, Ulla, and Schirmacher, Peter

Subjects
Adult, Male, medicine.medical_specialty, Hepatitis C virus, Medizin, Hepacivirus, medicine.disease_cause, Antiviral Agents, Immunotherapy, Adoptive, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, Germany, Internal medicine, Diabetes mellitus, Humans, Medicine, Pharmacology (medical), Registries, Adverse effect, Aged, business.industry, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, Clinical trial, Treatment Outcome, 030220 oncology & carcinogenesis, Cohort, Drug Therapy, Combination, Female, 030211 gastroenterology & hepatology, Safety, Geriatrics and Gerontology, business, Cohort study
Abstract

With the aging of the hepatitis C virus (HCV)-infected patient cohort and the availability of highly effective and tolerable treatment regimens, an increasing number of elderly patients are now eligible for HCV therapy. This study investigated clinical and epidemiologic characteristics of elderly HCV-infected patients as well as the effectiveness and safety of available therapies. Patients were enrolled into the German Hepatitis C Registry (DHC-R), a prospective, multicenter, real-world cohort study. Patients were treated at the discretion of the physician, and data were collected by a web-based system. Of 7133 patients who initiated treatment, 686 (9.6%) were > 70 years of age. In patients > 70 years, intent-to-treat (ITT) SVR12 was 92.6% (514/555) compared to 90.7% (4521/4985) in patients ≤ 70 years of age. Overall, adverse events (AEs) were reported in 374 (54.5%) and 3435 patients (53.3%) > 70 or ≤ 70 years of age; 7.6% (52) and 3.6% (235) in the respective age groups had a serious AE. Twenty-two (3.2%) and 62 (1.0%) of the patients > 70 or ≤ 70 years discontinued treatment due to AEs. Death was reported in 34 patients, of whom eight were > 70 years of age. Frequent comorbidities in patients > 70 years of age were cardiac disease, renal disease and diabetes. Psychiatric disorders, substance abuse and viral co-infection were more frequent in younger patients. Direct-acting antiviral therapies were well tolerated in patients older than 70 years. SVR12 rates in the elderly patient group were similar to those observed in younger patients. Differences in the prevalence of comorbidities between age groups warrant individualized attention with respect to drug–drug interactions and therapy adherence. The study was registered in the German Clinical Trials Register, DRKS-ID: DRKS00009717.

Published
2018
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40. Real-World Clinical Management of Patients with Primary Biliary Cholangitis—A Retrospective Multicenter Study from Germany

Author

Wilde, Anne-Christin Beatrice, primary, Lieb, Charlotte, additional, Leicht, Elise, additional, Greverath, Lena Maria, additional, Steinhagen, Lara Marleen, additional, Wald de Chamorro, Nina, additional, Petersen, Jörg, additional, Hofmann, Wolf Peter, additional, Hinrichsen, Holger, additional, Heyne, Renate, additional, Berg, Thomas, additional, Naumann, Uwe, additional, Schwenzer, Jeannette, additional, Vermehren, Johannes, additional, Geier, Andreas, additional, Tacke, Frank, additional, and Müller, Tobias, additional

Published
2021
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41. TOP-110 - Increasing functional cure rate beyond 96 weeks after discontinuation of nucleos (t)ide analogue treatment in HBeAg-negative chronic hepatitis B: follow-up of the stop-NUC trial

Author

van Bömmel, Florian, Stein, Kerstin, Heyne, Renate, Petersen, Jörg, Buggisch, Peter, Berg, Christoph, Zeuzem, Stefan, Stallmach, Andreas, Sprinzl, Martin, Schott, Eckart, Pathil-Warth, Anita, von Arnim, Ulrike, Keitel, Verena, Lohmeyer, Jürgen, Georg, Simon Karl, Trautwein, Christian, Trein, Andreas, Hüppe, Dietrich, Cornberg, Markus, Lammert, Frank, Ingiliz, Patrick, Zachoval, Reinhart, Hinrichsen, Holger, Zipprich, Alexander, Klinker, Hartwig, zur Wiesch, Julian Schulze, Schmiedeknecht, Anett, Brosteanu, Oana, and Berg, Thomas

Published
2023
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42. LBO-03 - A phase 3, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of cilofexor in patients with non-cirrhotic primary sclerosing cholangitis (PRIMIS)

Author

Trauner, Michael, Levy, Cynthia, Tanaka, Atsushi, Goodman, Zachary, Thorburn, Douglas, Joshi, Deepak, Salminen, Kimmo, Yimam, Kidist, Isayama, Hiroyuki, Montano-Loza, Aldo J, Danta, Mark, Hinrichsen, Holger, Invernizzi, Pietro, Liu, Xiangyu, Lu, Xiaomin, Alani, Muhsen, Barchuk, William, Watkins, Timothy R., Genovese, Mark, and Bowlus, Christopher

Published
2023
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47. Hepatitis C population in Germany, changing over time: 958

Author

Klass, Dietmar M., Hinrichsen, Holger, Boeker, Klaus H., Teuber, Gerlinde, Naumann, Uwe, von Lucadou, Armand, Antoni, Christoph, Jung, Maria-Christina, Ullrich, Rainer, Herrmann, Andreas, Weber, Andreas, Gösseringer, Roger, Hueppe, Dietrich, and Mauss, Stefan

Published
2012

48. The IL-28B Genotype is not associated with early HCVRNA negativity in Caucasian patients with symptomatic acute HCV infection: 803

Author

Deterding, Katja, Grüner, Norbert, Buggisch, Peter, Wiegand, Johannes, Galle, Peter R., Spengler, Ulrich, Hinrichsen, Holger, Berg, Thomas, Potthoff, Andrej, Malek, Nisar, Grosshennig, Anika, Koch, Armin, Diepolder, Helmut M., Lüth, Stefan, Feyerabend, Sandra, Jung, Maria C., Rogalska-Taranta, Magdalena, Schlaphoff, Verena, Cornberg, Markus, Manns, Michael P., and Wedemeyer, Heiner

Published
2012

49. Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1–3 Infections

Author

Dietz, Julia, primary, Spengler, Ulrich, additional, Müllhaupt, Beat, additional, Schulze zur Wiesch, Julian, additional, Piecha, Felix, additional, Mauss, Stefan, additional, Seegers, Barbara, additional, Hinrichsen, Holger, additional, Antoni, Christoph, additional, Wietzke-Braun, Perdita, additional, Peiffer, Kai-Henrik, additional, Berger, Annemarie, additional, Matschenz, Katrin, additional, Buggisch, Peter, additional, Backhus, Johanna, additional, Zizer, Eugen, additional, Boettler, Tobias, additional, Neumann-Haefelin, Christoph, additional, Semela, David, additional, Stauber, Rudolf, additional, Berg, Thomas, additional, Berg, Christoph, additional, Zeuzem, Stefan, additional, Vermehren, Johannes, additional, Sarrazin, Christoph, additional, Balavoine, J., additional, Giostra, E., additional, Berning, M., additional, Hampe, J., additional, De Gottardi, A., additional, Rauch, A., additional, Semmo, N., additional, Discher, T., additional, Trauth, J., additional, Fischer, J., additional, Gress, M., additional, Günther, R., additional, Heinzow, H., additional, Schmidt, J., additional, Herrmann, A., additional, Stallmach, A., additional, Hilgard, G., additional, Deterding, K., additional, Lange, C.M., additional, Ciesek, S., additional, Wedemeyer, H., additional, Hoffmann, D., additional, Klinker, H., additional, Schulze, P., additional, Kocheise, F., additional, Müller-Schilling, M., additional, Kodal, A., additional, Kremer, A., additional, Ganslmayer, M., additional, Siebler, J., additional, Lammert, F., additional, Rissland, J., additional, Löbermann, M., additional, Götze, T., additional, Canbay, A., additional, Lohse, A., additional, von Felden, J., additional, Jordan, S., additional, Maieron, A., additional, Moradpour, D., additional, Chave, J.-P., additional, Moreno, C., additional, Müller, T., additional, Muche, M., additional, Epple, H.-J., additional, Port, K., additional, von Hahn, T., additional, Cornberg, M., additional, Manns, M., additional, Reinhardt, L., additional, Ellenrieder, V., additional, Rockstroh, J., additional, Schattenberg, J., additional, Sprinzl, M., additional, Galle, P., additional, Roeb, E., additional, Steckstor, M., additional, Schmiegel, W., additional, Brockmeyer, N.H., additional, Seufferlein, T., additional, Stremmel, W., additional, Strey, B., additional, Thimme, R., additional, Teufel, A., additional, Vogelmann, R., additional, Ebert, M., additional, Tomasiewicz, K., additional, Trautwein, C., additional, Tacke, F., additional, Koenen, T., additional, Weber, T., additional, Zachoval, R., additional, Mayerle, J., additional, Raziorrouh, B., additional, Angeli, W., additional, Beckebaum, S., additional, Doberauer, C., additional, Durmashkina, E., additional, Hackelsberger, A., additional, Erhardt, A., additional, Garrido-Lüneburg, A., additional, Gattringer, H., additional, Genné, D., additional, Gschwantler, M., additional, Gundling, F., additional, Hametner, S., additional, Schöfl, R., additional, Hartmann, C., additional, Heyer, T., additional, Hirschi, C., additional, Jussios, A., additional, Kanzler, S., additional, Kordecki, N., additional, Kraus, M., additional, Kullig, U., additional, Wollschläger, S., additional, Magenta, L., additional, Beretta-Piccoli, B. Terziroli, additional, Menges, M., additional, Mohr, L., additional, Muehlenberg, K., additional, Niederau, C., additional, Paulweber, B., additional, Petrides, A., additional, Pinkernell, M., additional, Piso, R., additional, Rambach, W., additional, Reiser, M., additional, Riecken, B., additional, Rieke, A., additional, Roth, J., additional, Schelling, M., additional, Schlee, P., additional, Schneider, A., additional, Scholz, D., additional, Schott, E., additional, Schuchmann, M., additional, Schulten-Baumer, U., additional, Seelhoff, A., additional, Stich, A., additional, Stickel, F., additional, Ungemach, J., additional, Walter, E., additional, Weber, A., additional, Winzer, T., additional, Abels, W., additional, Adler, M., additional, Audebert, F., additional, Baermann, C., additional, Bästlein, E., additional, Barth, R., additional, Barthel, K., additional, Becker, W., additional, Behrends, J., additional, Benninger, J., additional, Berger, F., additional, Berzow, D., additional, Beyer, T., additional, Bierbaum, M., additional, Blaukat, O., additional, Bodtländer, A., additional, Böhm, G., additional, Börner, N., additional, Bohr, U., additional, Bokemeyer, B., additional, Bruch, H.R., additional, Bucholz, D., additional, Burkhard, O., additional, Busch, N., additional, Chirca, C., additional, Delker, R., additional, Diedrich, J., additional, Frank, M., additional, Diehl, M., additional, Dienethal, A., additional, Dietel, P., additional, Dikopoulos, N., additional, Dreck, M., additional, Dreher, F., additional, Drude, L., additional, Ende, K., additional, Ehrle, U., additional, Baumgartl, K., additional, Emke, F., additional, Glosemeyer, R., additional, Felten, G., additional, Hüppe, D., additional, Fischer, U., additional, Frederking, D., additional, Frick, B., additional, Friese, G., additional, Gantke, B., additional, Geyer, P., additional, Schwind, H.R., additional, Glas, M., additional, Glaunsinger, T., additional, Goebel, F., additional, Göbel, U., additional, Görlitz, B., additional, Graf, R., additional, Gruber, H., additional, Härter, G., additional, Herder, M., additional, Heuchel, T., additional, Heuer, S., additional, Höffl, K.-H., additional, Hörster, H., additional, Sonne, J.-U., additional, Hofmann, W.P., additional, Holst, F., additional, Hunstiger, M., additional, Hurst, A., additional, Jägel-Guedes, E., additional, John, C., additional, Jung, M., additional, Kallinowski, B., additional, Kapzan, B., additional, Kerzel, W., additional, Khaykin, P., additional, Klarhof, M., additional, Klüppelberg, U., additional, Klugewitz, K., additional, Knapp, B., additional, Knevels, U., additional, Kochsiek, T., additional, Körfer, A., additional, Köster, A., additional, Kuhn, M., additional, Langekamp, A., additional, Künzig, B., additional, Link, R., additional, Littman, M., additional, Löhr, H., additional, Lutz, T., additional, Knecht, G., additional, Lutz, U., additional, Mainz, D., additional, Mahle, I., additional, Maurer, P., additional, Mayer, C., additional, Meister, V., additional, Möller, H., additional, Heyne, R., additional, Moritzen, D., additional, Mroß, M., additional, Mundlos, M., additional, Naumann, U., additional, Nehls, O., additional, Ningel, K.&R., additional, Oelmann, A., additional, Olejnik, H., additional, Gadow, K., additional, Pascher, E., additional, Petersen, J., additional, Philipp, A., additional, Pichler, M., additional, Polzien, F., additional, Raddant, R., additional, Riedel, M., additional, Rietzler, S., additional, Rössle, M., additional, Rufle, W., additional, Rump, A., additional, Schewe, C., additional, Hoffmann, C., additional, Schleehauf, D., additional, Schmidt, K.J., additional, Schmidt, W., additional, Schmidt-Heinevetter, G., additional, Schmidtler-von Fabris, J., additional, Schnaitmann, E., additional, Schneider, L., additional, Schober, A., additional, Niehaus-Hahn, S., additional, Schwenzer, J., additional, Seidel, T., additional, Seitel, G., additional, Sick, C., additional, Simon, K.G., additional, Stähler, D., additional, Stenschke, F., additional, Steffens, H., additional, Stein, K., additional, Steinmüller, M., additional, Sternfeld, T., additional, Svensson, K., additional, Tacke, W., additional, Teuber, G., additional, Teubner, K., additional, Thieringer, J., additional, Tomesch, A., additional, Trappe, U., additional, Ullrich, J., additional, Urban, G., additional, Usadel, S., additional, von Lucadou, A., additional, Weinberger, F., additional, Werheid-Dobers, M., additional, Werner, P., additional, Winter, T., additional, Zehnter, E., additional, and Zipf, A., additional

Published
2021
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50. Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians

Author

Stickel, Felix, Buch, Stephan, Lau, Katharina, zu Schwabedissen, Henriette Meyer, Berg, Thomas, Ridinger, Monika, Rietschel, Marcella, Schafmayer, Clemens, Braun, Felix, Hinrichsen, Holger, Günther, Rainer, Arlt, Alexander, Seeger, Marcus, Müller, Sebastian, Seitz, Helmut Karl, Soyka, Michael, Lerch, Markus, Lammert, Frank, Sarrazin, Christoph, Kubitz, Ralf, Häussinger, Dieter, Hellerbrand, Claus, Bröring, Dieter, Schreiber, Stefan, Kiefer, Falk, Spanagel, Rainer, Mann, Karl, Datz, Christian, Krawczak, Michael, Wodarz, Norbert, Völzke, Henry, and Hampe, Jochen

Published
2011
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