Search

Your search keyword '"Hinman, Andrew"' showing total 11 results
Start Over Author "Hinman, Andrew"
11 results on '"Hinman, Andrew"'

3. Pungent products from garlic activate the sensory ion channel TRPA1

Author

Bautista, Diana M., Movahed, Pouya, Hinman, Andrew, Axelsson, Helena E., Sterner, Olov, Hogestatt, Edward D., Julius, David, Jordt, Sven-Eric, and Zygmunt, Peter M.

Subjects
Garlic -- Research, Inflammation -- Research, Blood vessels -- Dilatation, Blood vessels -- Research, Science and technology
Abstract

Garlic belongs to the Allium family of plants that produce organosulfur compounds, such as allicin and diallyl disulfide (DADS), which account for their pungency and spicy aroma. Many health benefits have been ascribed to Allium extracts, including hypotensive and vasorelaxant activities. However, the molecular mechanisms underlying these effects remain unknown. Intriguingly, allicin and DADS share structural similarities with allyl isothiocyanate, the pungent ingredient in wasabi and other mustard plants that induces pain and inflammation by activating TRPA1, an excitatory ion channel on primary sensory neurons of the pain pathway. Here we show that allicin and DADS excite an allyl isothiocyanate-sensitive subpopulation of sensory neurons and induce vasodilation by activating capsaicin-sensitive perivascular sensory nerve endings. Moreover, allicin and DADS activate the cloned TRPA1 channel when expressed in heterologous systems. These and other results suggest that garlic excites sensory neurons primarily through activation of TRPA1. Thus different plant genera, including Allium and Brassica, have developed evolutionary convergent strategies that target TRPA1 channels on sensory nerve endings to achieve chemical deterrence. inflammation | pain | TRP channel | vasodilation | natural products

Published
2005

4. Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy

Author

Kahn-Kirby, Amanda H., primary, Amagata, Akiko, additional, Maeder, Celine I., additional, Mei, Janet J., additional, Sideris, Steve, additional, Kosaka, Yuko, additional, Hinman, Andrew, additional, Malone, Stephanie A., additional, Bruegger, Joel J., additional, Wang, Leslie, additional, Kim, Virna, additional, Shrader, William D., additional, Hoff, Kevin G., additional, Latham, Joey C., additional, Ashley, Euan A., additional, Wheeler, Matthew T., additional, Bertini, Enrico, additional, Carrozzo, Rosalba, additional, Martinelli, Diego, additional, Dionisi-Vici, Carlo, additional, Chapman, Kimberly A., additional, Enns, Gregory M., additional, Gahl, William, additional, Wolfe, Lynne, additional, Saneto, Russell P., additional, Johnson, Simon C., additional, Trimmer, Jeffrey K., additional, Klein, Matthew B., additional, and Holst, Charles R., additional

Published
2019
Full Text
View/download PDF

5. Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase

Author

Hinman, Andrew, primary, Holst, Charles R., additional, Latham, Joey C., additional, Bruegger, Joel J., additional, Ulas, Gözde, additional, McCusker, Kevin P., additional, Amagata, Akiko, additional, Davis, Dana, additional, Hoff, Kevin G., additional, Kahn-Kirby, Amanda H., additional, Kim, Virna, additional, Kosaka, Yuko, additional, Lee, Edgar, additional, Malone, Stephanie A., additional, Mei, Janet J., additional, Richards, Steve James, additional, Rivera, Veronica, additional, Miller, Guy, additional, Trimmer, Jeffrey K., additional, and Shrader, William D., additional

Published
2018
Full Text
View/download PDF

6. A stereoselective synthesis of (-)- tetrodotoxin

Author

Hinman, Andrew and Bois, J. Du

Subjects
Tetrodotoxin -- Research, Chemistry
Abstract

The asymmetric synthesis of (-)-tetrodotoxin (TTX) is discussed. It is possible to enrich the ratio of TTX to ~4:1 by standing in aqueous acid for 5 days.

Published
2003

9. EPI-743 reverses the progression of the pediatric mitochondrial disease—Genetically defined Leigh Syndrome

Author

Martinelli, Diego, primary, Catteruccia, Michela, additional, Piemonte, Fiorella, additional, Pastore, Anna, additional, Tozzi, Giulia, additional, Dionisi-Vici, Carlo, additional, Pontrelli, Giuseppe, additional, Corsetti, Tiziana, additional, Livadiotti, Susanna, additional, Kheifets, Viktoria, additional, Hinman, Andrew, additional, Shrader, William D., additional, Thoolen, Martin, additional, Klein, Matthew B., additional, Bertini, Enrico, additional, and Miller, Guy, additional

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results