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2. OSARI, an Open-Source Anticipated Response Inhibition Task.

Author

He, JL, Hirst, RJ, Puri, R, Coxon, J, Byblow, W, Hinder, M, Skippen, P, Matzke, D, Heathcote, A, Wadsley, CG, Silk, T, Hyde, C, Parmar, D, Pedapati, E, Gilbert, DL, Huddleston, DA, Mostofsky, S, Leunissen, I, MacDonald, HJ, Chowdhury, NS, Gretton, M, Nikitenko, T, Zandbelt, B, Strickland, L, Puts, NAJ, He, JL, Hirst, RJ, Puri, R, Coxon, J, Byblow, W, Hinder, M, Skippen, P, Matzke, D, Heathcote, A, Wadsley, CG, Silk, T, Hyde, C, Parmar, D, Pedapati, E, Gilbert, DL, Huddleston, DA, Mostofsky, S, Leunissen, I, MacDonald, HJ, Chowdhury, NS, Gretton, M, Nikitenko, T, Zandbelt, B, Strickland, L, and Puts, NAJ

Abstract

The stop-signal paradigm has become ubiquitous in investigations of inhibitory control. Tasks inspired by the paradigm, referred to as stop-signal tasks, require participants to make responses on go trials and to inhibit those responses when presented with a stop-signal on stop trials. Currently, the most popular version of the stop-signal task is the 'choice-reaction' variant, where participants make choice responses, but must inhibit those responses when presented with a stop-signal. An alternative to the choice-reaction variant of the stop-signal task is the 'anticipated response inhibition' task. In anticipated response inhibition tasks, participants are required to make a planned response that coincides with a predictably timed event (such as lifting a finger from a computer key to stop a filling bar at a predefined target). Anticipated response inhibition tasks have some advantages over the more traditional choice-reaction stop-signal tasks and are becoming increasingly popular. However, currently, there are no openly available versions of the anticipated response inhibition task, limiting potential uptake. Here, we present an open-source, free, and ready-to-use version of the anticipated response inhibition task, which we refer to as the OSARI (the Open-Source Anticipated Response Inhibition) task.

Published
2022

5. OSARI, an Open-Source Anticipated Response Inhibition Task

Author

He, JL, Hirst, RJ, Puri, R, Coxon, J, Byblow, W, Hinder, M, Skippen, P, Matzke, D, Heathcote, A, Wadsley, CG, Silk, Tim, Hyde, Christian, Parmar, D, Pedapati, E, Gilbert, DL, Huddleston, DA, Mostofsky, S, Leunissen, I, MacDonald, HJ, Chowdhury, NS, Gretton, M, Nikitenko, T, Zandbelt, B, Strickland, L, Puts, NAJ, He, JL, Hirst, RJ, Puri, R, Coxon, J, Byblow, W, Hinder, M, Skippen, P, Matzke, D, Heathcote, A, Wadsley, CG, Silk, Tim, Hyde, Christian, Parmar, D, Pedapati, E, Gilbert, DL, Huddleston, DA, Mostofsky, S, Leunissen, I, MacDonald, HJ, Chowdhury, NS, Gretton, M, Nikitenko, T, Zandbelt, B, Strickland, L, and Puts, NAJ

Abstract

AbstractThe stop-signal paradigm has become ubiquitous in investigations of inhibitory control. Tasks inspired by the paradigm, referred to as stop-signal tasks, require participants to make responses on go trials and to inhibit those responses when presented with a stop-signal on stop trials. Currently, the most popular version of the stop-signal task is the ‘choice-reaction’ variant, where participants make choice responses, but must inhibit those responses when presented with a stop-signal. An alternative to the choice-reaction variant of the stop-signal task is the ‘anticipated response inhibition’ task. In anticipated response inhibition tasks, participants are required to make a planned response that coincides with a predictably timed event (such as lifting a finger from a computer key to stop a filling bar at a predefined target). Anticipated response inhibition tasks have some advantages over the more traditional choice-reaction stop-signal tasks and are becoming increasingly popular. However, currently, there are no openly available versions of the anticipated response inhibition task, limiting potential uptake. Here, we present an open-source, free, and ready-to-use version of the anticipated response inhibition task, which we refer to as the OSARI (the Open-Source Anticipated Response Inhibition) task.

Published
2021

8. The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial

Author

Tarnow-Mordi, William O, primary, Abdel-Latif, Mohamed E, additional, Martin, Andrew, additional, Pammi, Mohan, additional, Robledo, Kristy, additional, Manzoni, Paolo, additional, Osborn, David, additional, Lui, Kei, additional, Keech, Anthony, additional, Hague, Wendy, additional, Ghadge, Alpana, additional, Travadi, Javeed, additional, Brown, Rebecca, additional, Darlow, Brian A, additional, Liley, Helen, additional, Pritchard, Margo, additional, Kochar, Anu, additional, Isaacs, David, additional, Gordon, Adrienne, additional, Askie, Lisa, additional, Cruz, Melinda, additional, Schindler, Tim, additional, Dixon, Kelly, additional, Deshpande, Girish, additional, Tracy, Mark, additional, Schofield, Deborah, additional, Austin, Nicola, additional, Sinn, John, additional, Simes, R John, additional, Black, R., additional, Nie, W., additional, Reid, S., additional, Michalowski, J., additional, McKeown, L., additional, Koorts, P., additional, Broom, M., additional, Kwan, P., additional, Morris, S., additional, Cornthwaite, K., additional, Tobiansky, R., additional, Darcy, D., additional, Goodchild, L., additional, Collins, C., additional, Noble, E., additional, Lewis, A., additional, Yeomans, E., additional, Hua, C., additional, Hinder, M., additional, Bhaskaracharya, A., additional, Graham, P., additional, Patel, H., additional, Wilkes, N, additional, Marlow, N., additional, Soll, R., additional, McKinlay, C., additional, Modi, N., additional, Marschner, I., additional, Stenson, B., additional, and Espinoza, D., additional

Published
2020
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17. Upregulation of cortico-cerebellar functional connectivity after motor learning

Author

Mehrkanoon, S, Boonstra, TW, Breakspear, M, Hinder, M, Summers, JJ, Mehrkanoon, S, Boonstra, TW, Breakspear, M, Hinder, M, and Summers, JJ

Abstract

Interactions between the cerebellum and primary motor cortex are crucial for the acquisition of new motor skills. Recent neuroimaging studies indicate that learning motor skills is associated with subsequent modulation of resting-state functional connectivity in the cerebellar and cerebral cortices. The neuronal processes underlying the motor-learning-induced plasticity are not well understood. Here, we investigate changes in functional connectivity in source-reconstructed electroencephalography (EEG) following the performance of a single session of a dynamic force task in twenty young adults. Source activity was reconstructed in 112 regions of interest (ROIs) and the functional connectivity between all ROIs was estimated using the imaginary part of coherence. Significant changes in resting-state connectivity were assessed using partial least squares (PLS). We found that subjects adapted their motor performance during the training session and showed improved accuracy but with slower movement times. A number of connections were significantly upregulated after motor training, principally involving connections within the cerebellum and between the cerebellum and motor cortex. Increased connectivity was confined to specific frequency ranges in the mu- and beta-bands. Post hoc analysis of the phase spectra of these cerebellar and cortico-cerebellar connections revealed an increased phase lag between motor cortical and cerebellar activity following motor practice. These findings show a reorganization of intrinsic cortico-cerebellar connectivity related to motor adaptation and demonstrate the potential of EEG connectivity analysis in source space to reveal the neuronal processes that underpin neural plasticity.

Published
2016

19. 9C.04

Author

Wang, T.D., primary, Tan, R.S., additional, Lee, H., additional, Ihm, S.H., additional, Rhee, M.Y., additional, Tomlinson, B., additional, Pal, P., additional, Yang, F., additional, Hirschhorn, B., additional, Hinder, M., additional, and Langenickel, T.H., additional

Published
2015
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20. PP.07.24

Author

Wang, T.D., primary, Tan, R.S., additional, Lee, H., additional, Ihm, S.H., additional, Rhee, M.Y., additional, Tomlinson, B., additional, Pal, P., additional, Yang, F., additional, Hirschhorn, B., additional, Prescott, M., additional, Hinder, M., additional, and Langenickel, T.H., additional

Published
2015
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31. Pharmacokinetic/pharmacodynamic relationships for otamixaban, a direct factor Xa inhibitor, in healthy subjects.

Author

Paccaly A, Frick A, Ozoux ML, Chu V, Rosenburg R, Hinder M, Shukla U, and Jensen BK

Abstract

Direct pharmacokinetic/pharmacodynamic relationships for otamixaban were investigated after rising doses in healthy subjects using mixed-effect modeling. Activated partial thromboplastin time, prothrombin time, dilute prothrombin time, and Russell's viper venom-induced clotting time (RVVT) related linearly, whereas Heptest clotting time (HCT) followed a sigmoidal E(max) model. The pharmacokinetic/pharmacodynamic response (slope) and their corresponding interindividual variability (seconds per ng/mL, [% coefficient of variation]) were 0.263 (29%) for Russell's viper venom-induced clotting time, 0.117 (10%) for dilute prothrombin time, 0.058 (19%) for activated partial thromboplastin time, and 0.021 (11%) for prothrombin time. For Heptest clotting time, the parameter estimates with their corresponding interindividual variability (% coefficient of variation) were 71 ng/mL (30%) for EC(50), 186 seconds (64%) for E(max), and 17 seconds (16%) for E(0). The model predicted otamixaban plasma concentrations to double the clotting times that were close to those observed. These pharmacokinetic/pharmacodynamic relationships, together with the predictable pharmacokinetics, allowed the anticoagulant effect at given doses of otamixaban to be foreseen in healthy subjects. [ABSTRACT FROM AUTHOR]

Published
2006

32. Pharmacokinetics of otamixaban, a direct factor Xa inhibitor, in healthy male subjects: pharmacokinetic model development for phase 2/3 simulation of exposure.

Author

Paccaly A, Frick A, Rohatagi S, Liu J, Shukla U, Rosenburg R, Hinder M, and Jensen BK

Abstract

The pharmacokinetics of otamixaban was investigated in healthy male subjects over a wide range of intravenous doses, with duration of administration varying between 1-minute infusions (bolus dose) and 24-hour infusions, using noncompartmental and multicompartmental methods. A global compartmental analysis (2 and 3 compartments) generated a single set of pharmacokinetic parameters, regardless of infusion rate and duration, and took into account the 30% decrease in clearance and volume of distribution observed over the dose range. The 2-compartment model was retained to predict bolus plus 3-hour-infusion doses of otamixaban for future phase (2/3) studies. Otamixaban exhibited in healthy subjects several interesting pharmacokinetic features in view of its potential therapeutic use in coronary thrombosis: a rapid plasma distribution and elimination, a well-described dose-exposure relationship, a low intersubject variability in plasma exposure, and a mixed renal and biliary excretion with constant renal clearance. [ABSTRACT FROM AUTHOR]

Published
2006

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