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Background/Objective Investigate real-world patients receiving faricimab for the treatment of neovascular age-related macular degeneration (nAMD). Subjects/Methods Multicenter, retrospective chart review was conducted on patients treated with faricimab for nAMD from February 2022 to September 2022. Collected data includes background demographics, treatment history, best-corrected visual acuity (BCVA), anatomic changes, and adverse events as safety markers. The main outcome measures are changes in BCVA, changes in central subfield thickness (CST) and adverse events. Secondary outcome measures included treatment intervals and presence of retinal fluid. Results After one injection of faricimab, all eyes (n = 376), previously-treated (n = 337) and treatment-naïve (n = 39) eyes demonstrated a + 1.1 letter (p = 0.035), a + 0.7 letter (p = 0.196) and a + 4.9 letter (p = 0.076) improvement in BCVA, respectively, and a − 31.3 μM (p p p n = 94), previously-treated (n = 81) and treatment-naïve (n = 13) eyes demonstrated a + 3.4 letter (p = 0.03), a + 2.7 letter (p = 0.045) and a + 8.1 letter (p = 0.437) improvement in BCVA, and a − 43.4 μM (p p p Conclusions Faricimab has demonstrated improvement or maintenance of visual acuity for patients with nAMD, along with rapid improvement of anatomical parameters. It has been well-tolerated with low incidence of treatable intraocular inflammation. Future data will continue to investigate faricimab for real-world patients with nAMD.

Purpose: We describe a branch retinal artery occlusion (BRAO) in a pregnant woman and optical coherence tomography angiography (OCTA) as a dye-free alternative to assess retinal vasculature in this population. Methods: Serum lipids, blood sugar, carotid duplex, and transthoracic echocardiogram were collected. Fundus photography, optical coherence tomography, autofluorescence, and OCTA were used as imaging modalities. OCTA demonstrated a flow defect along a cilioretinal artery branch. Results: An atrial septal aneurysm was identified on transthoracic echocardiography. The patient was placed on anticoagulation for the duration of her pregnancy. Transesophageal echocardiogram postpartum revealed an atrial septal defect. Conclusions: Association of BRAO and atrial septal aneurysm with patent foramen ovale have not been described in pregnancy. Furthermore, OCTA has not been used in pregnancy to demonstrate retinal artery occlusion. OCTA can safely characterize retinal vasculature in pregnancy without the use of intravenous dye.

Objective The objective of this study was to review the treatment outcomes of patients with secondary glaucoma in cases of autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV), a hereditary autoimmune uveitis due to mutations in CAPN5. Patients and methods A retrospective, observational case series was assembled from ADNIV patients with secondary glaucoma. The main outcome measures were intraocular pressure (IOP), visual acuity, use of antiglaucoma medications, ocular surgeries, and adverse outcomes. Perimetry and optic disk optical coherence tomography (OCT) were also analyzed. Results Nine eyes of five ADNIV patients with secondary glaucoma were reviewed. Each received a fluocinolone acetonide (FA) implant for the management of posterior uveitis. Following implantation, no eyes developed neovascular glaucoma. Five eyes (in patients 1, 2, and 5) required Ahmed glaucoma valve surgery for the management of steroid-responsive glaucoma. Patient 2 also developed angle closure with iris bombe and underwent laser peripheral iridotomy. Patient 4 had both hypotony and elevated IOP that required periodic antiglaucoma medication in the FA-implanted eye. Patient 3 did not develop steroid-response glaucoma in either eye. Optic disk examinations were obscured by fibrosis and better assessed with OCT. Conclusion ADNIV patients show combined mechanism secondary glaucoma best assessed by OCT of the optic disk. The FA implants have reduced uveitic and neovascular glaucoma. Nevertheless, IOP management remains complex due to steroid-response glaucoma, angle closure glaucoma, and hypotony.

Perifoveal exudative anomalous complex (PEVAC) is an uncommon entity that occurs in isolation or in association with retinal vascular disorders. The authors describe a case of a 47-year-old man presenting with a central scotoma in the left eye found to have an isolated PEVAC. Fundus photography, optical coherence tomography (OCT), and intravenous fluorescein angiography were collected. OCT angiography of the lesion revealed suspended scattered particles in motion, a newly described finding in exudative macular retinopathies. The authors describe the first case of PEVAC with angiographic evidence of suspended scattered particles in motion. [ Ophthalmic Surg Lasers Imaging Retina . 2019;50:796–800.]

Pediatric uveitis is a significant cause of ocular morbidity and poses diagnostic and treatment dilemmas to ophthalmologists. The spectrum of clinical presentation, difficulty in examination of children, and lifetime burden of vision loss without adequate treatment are the main challenges in management of pediatric uveitis. While infectious and noninfectious, systemic autoimmune conditions may be associated with pediatric uveitis, juvenile idiopathic arthritis remains the most common associated disease condition. Coordination with pediatric rheumatologists and primary care physicians is important to provide comprehensive, multidisciplinary care. While traditional disease-modifying antirheumatic drugs such as methotrexate remain a mainstay for noninfectious pediatric uveitis to avoid complications of topical ophthalmic corticosteroids, the biologic agents, notably the anti-tumor necrosis factor-alpha inhibitors adalimumab and infliximab, have been increasingly used given their benefit in the control of ocular inflammation. This chapter summarizes the common causes of pediatric uveitis and the management approach to the spectrum of disease entities.

Microperimetry (fundus-guided perimetry) has been utilized to evaluate and monitor various types of macular diseases. The main advantage is its ability to correlate the morphologic changes to functional aspects of retinal sensitivity. Automated microperimetry has demonstrated a new role in monitoring the progression of various uveitides.