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1. The Role of Preoperative Case Selection in the Training of Surgical Repair of Primary Rhegmatogenous Retinal Detachment

Author

William A, Kuehnel S, Dimopoulos S, Hillenkamp J, and Goebel W

Subjects
primary rhegmatogenous retinal detachment (rrd), pars plana vitrectomy (ppv), encircling band (cb)., Ophthalmology, RE1-994
Abstract

Antony William,1 Sophia Kuehnel,1 Spyridon Dimopoulos,2 Jost Hillenkamp,1 Winfried Goebel1 1Department of Ophthalmology, University Eye Hospital Würzburg, Würzburg, Germany; 2Department of Ophthalmology, University Eye Hospital Tübingen, Tübingen, GermanyCorrespondence: Antony William, Department of Ophthalmology, University Hospital Würzburg, Josef–Schneider Straße 11, Würzburg, 97080, Germany, Tel +4993120120646, Email William_a@ukw.dePurpose: To analyse single-operation anatomical success (SOAS) of primary rhegmatogenous retinal detachment (RRD) repair by junior vitreoretinal surgeons guided by preoperative individual case selection by an experienced mentor vitreoretinal surgeon.Methods: Retrospective, single institute, observational study, included all patients who underwent standard pars plana vitrectomy (PPV) or combined encircling band (CB) and PPV and gas tamponade in the treatment of RRD from November 2021 to December 2022 were included. Preoperative selection for the surgery decision, whether standard PPV or combined CB & PPV was undertaken through the senior surgeon; according to the location and extensions of the RRD, number of retinal tears (RT) and lens status. We excluded patients with tractional retinal detachment, RD with proliferative vitreoretinopathy stage C, giant tears, trauma, previous scleral buckle, schisis RD and RD requiring silicone oil. The primary outcome measure was to evaluate the single-operation anatomic success (SOAS). Secondary outcome measures evaluated whether there was a statistical significant difference between both procedures.Results: Eighty-two eyes were included in the study. Forty-five eyes were selected for combined CB&PPV and 37 eyes for standard PPV. SOAS was achieved in 40 eyes (88.8%) in combined group and 35 eyes (94.5%) in standard PPV group. There was no statistically significant difference in the success rate between both operations, p = 0.65.Conclusion: Structured preoperative selection of standardized surgical techniques according to the degree of complexity of RD together with close supervision enables junior vitreoretinal surgeons in training to achieve re-attachment rates of more than 80% with both types of surgeries.Keywords: primary rhegmatogenous retinal detachment, RRD, pars plana vitrectomy, PPV, encircling band, CB

Published
2023

2. Morphological Macular Changes Under Brolucizumab Treatment for Neovascular Age-Related Macular Degeneration Refractory to Previous Anti-VEGF Treatment Compared with Treatment-Naive Eyes

Author

William A, Verma-Fuehring R, Kuehnel S, Schwabe D, Kampik D, Goebel W, and Hillenkamp J

Subjects
treatment naive (tn) and refractory treatment (rt)., Ophthalmology, RE1-994
Abstract

Antony William, Raoul Verma-Fuehring, Sophia Kuehnel, Dorothee Schwabe, Daniel Kampik, Winfried Goebel, Jost Hillenkamp Department of Ophthalmology, University Hospital Würzburg, Würzburg, GermanyCorrespondence: Antony William, Department of Ophthalmology, University Hospital Würzburg, Joseph–Schneider Straße 11, Würzburg, 97080, Germany, Tel +4993120120646, Email William_a@ukw.dePurpose: To evaluate the morphological macular changes and fluid dynamics under brolucizumab treatment in eyes refractory to previous anti–vascular endothelial growth factor (anti-VEGF) treatment for neovascular age-related macular degeneration (nAMD) compared with treatment-naive eyes.Methods: Retrospective study of all eyes treated with brolucizumab for nAMD between 2020 and 2021 with a fixed injection regimen and one year follow-up. Treatment-naive eyes (TN) were compared with eyes refractory to previous treatment with bevacizumab, ranibizumab, or aflibercept (RT). The primary outcome measure was change of best-corrected visual acuity (BCVA). Secondary outcome measures included foveal central thickness (FCT), presence of intra- or subretinal fluid (IRF, SRF) and presence of pigment epithelial detachment (PED) at any time point during treatment in both groups.Results: Seventeen TN eyes and 17 RT eyes were included. Mean BCVA and mean FCT in TN eyes had significantly improved after 3 months and continued to improve during treatment (p< 0.05 and p=0.001, respectively). In RT eyes, mean BCVA did not change significantly while mean FCT had improved after 3 months of treatment and remained stable thereafter. SRF or PED were more frequent in RT eyes compared with TN eyes (p=0.003 and p=0.005, respectively).Conclusion: After 3 months of treatment, the BCVA increased significantly only in TN eyes, while the FCT was significantly reduced in both groups. IRF appears to be similarly seen in both groups after the loading phase; however, SRF and PED appear to be more frequent in the RT eyes compared with TN eyes.Keywords: treatment naïve, TN, refractory treatment, RT

Published
2023

8. Baseline visual acuity strongly predicts visual acuity gain in patients with diabetic macular edema following anti-vascular endothelial growth factor treatment across trials

Author

Dugel PU, Hillenkamp J, Sivaprasad S, Vögeler J, Mousseau MC, Wenzel A, Margaron P, Hashmonay R, and Massin P

Subjects
aflibercept, anti-vascular endothelial growth factor, best corrected visual acuity, cross-trial comparison, diabetic macular edema, ranibizumab., Ophthalmology, RE1-994
Abstract

Pravin U Dugel,1,2 Jost Hillenkamp,3 Sobha Sivaprasad,4,5 Jessica Vögeler,6 Marie-Catherine Mousseau,7 Andreas Wenzel,8 Philippe Margaron,8 Ron Hashmonay,8 Pascale Massin9 1Retinal Consultants of Arizona LTD, Retinal Research Institute LLC, Phoenix, AZ, 2USC Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; 3Department of Ophthalmology, Julius-Maximilians University, Würzburg, Germany; 4NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, 5King’s College Hospital, London, UK; 6Novartis Pharma GmbH, Nürnberg, Germany; 7Novartis Ireland Limited, Dublin, Ireland; 8Novartis Pharma AG, Basel, Switzerland; 9Department of Ophthalmology, Hôpital Lariboisière, Assistance Publique des Hôpitaux de Paris, Université Paris Diderot, Paris, France Objective: This study was designed to evaluate the correlation of baseline visual acuity (VA) with VA outcome in response to anti-vascular endothelial growth factor (VEGF) in diabetic macular edema using a retrospective analysis of nine clinical trials. The result will help assess the relevance of VA gain comparisons across trials. Methods: A correlation analysis was performed between mean baseline VA and VA gain at month 12 for 1,616 diabetic macular edema patients across nine randomized clinical trials (RESOLVE, RISE, RIDE, RESTORE, RETAIN, DRCR.net Protocol I, DA VINCI, VIVID, VISTA) with anti-VEGF treatment regimens ranibizumab 0.5 mg and aflibercept 2 mg. Results: The mean baseline VA ranged from 56.9 to 64.8 Early Treatment Diabetic Retinopathy Study (ETDRS) letters. The mean VA gain at month 12 ranged from 6.8 to 13.1 ETDRS letters across trials. There was a strong inverse correlation between mean baseline VA and VA gain at month 12 (r=-0.85). The mean VA at 12 months plateaued at ~70 (68.5–73.0) ETDRS letters (20/40 Snellen VA equivalent) for the anti-VEGF treatment groups from all trials, regardless of dosing regimens and agents. Conclusion: Cross-trial comparisons based on changes in best-corrected visual acuity should be done cautiously and only after adjusting for best-corrected visual acuity at baseline. Furthermore, the total VA afforded by treatment appears to be subject to a plateau effect, which warrants further exploration. Keywords: aflibercept, anti-vascular endothelial growth factor, best-corrected visual acuity, cross-trial comparison, diabetic macular edema, ranibizumab

Published
2016

12. Vitrectomy with or without encircling band for pseudophakic retinal detachment: a multi-centre, three-arm, randomised clinical trial. VIPER Study Report No. 1—design and enrolment

Author

Mazinani, B, Baumgarten, S, Schiller, P, Agostini, H, Helbig, H, Limburg, E, Hellmich, M, Walter, P, Aisenbrey, S, Bartz-Schmidt, U, Bornfeld, N, Clemens, C, Dahlke, C, Eter, N, Fauser, S, Feltgen, N, Gamulescu, MA, Gök, M, Hillenkamp, J, Holz, F, Jochmann, C, Joussen, A, Junker, B, Kirchhof, B, Lappas, A, Lommatzsch, A, Lüke, M, Meier, P, Ne, T, Nestler, A, Partsch, M, Pielen, A, Rasche, W, Ritzau-Tondrow, U, Rössler, G, Roider, J, Rudolf, M, Uhlig, C, Wiedemann, P, Pfeiffer, A, and Wei, C

Published
2016
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13. HIOP-Reader: Automated Data Extraction for the Analysis of Manually Recorded Nycthemeral IOPs and Glaucoma Progression

Author

Puppe F, Schoen J, Agorastou, Dakroub M, Hillenkamp J, Loewen Na, and Verma-Fuehring R

Subjects
genetic structures, Computer science, business.industry, Extraction (chemistry), Glaucoma, IOPS, Pattern recognition, medicine.disease, eye diseases, Automated data, Text mining, medicine, sense organs, Artificial intelligence, business
Abstract

Purpose: Nycthemeral (24-hour) glaucoma inpatient intraocular pressure (IOP) monitoring has been used in Europe for more than 100 years to detect peaks missed during regular office hours. Data supporting this practice is lacking, partially because it is difficult to correlate manually drawn IOP curves to objective glaucoma progression. To address this, we deployed automated IOP data extraction tools and tested for a correlation to a progressive retinal nerve fiber layer loss on spectral-domain optical coherence tomography (SDOCT). Methods: We created and deployed a machine-learning image analysis software to extract IOP data from hand-drawn, nycthemeral IOP curves of 225 retrospectively identified glaucoma patients. The relationship between demographic parameters, IOP and mean ocular perfusion pressure (MOPP) data to SDOCT data was analyzed. Sensitivities and specificities for the historical cut-off values of 15 mmHg and 22 mmHg in detecting glaucoma progression were calculated. Results: IOP data could be extracted efficiently. The IOP average was 15.2±4.0 mmHg, nycthemeral IOP variation was 6.9±4.2 mmHg, and MOPP was 59.1±8.9 mmHg. Peak IOP occurred at 10 AM and trough at 9 PM. Disease progression occurred mainly in the temporal-superior and -inferior SDOCT sectors. No correlation could be established between demographic, IOP, or MOPP parameters and SDOCT disease progression. The sensitivity and specificity of both cut-off points (15 and 22 mmHg) were insufficient to be clinically useful. Outpatient IOPs were non-inferior to nycthemeral IOPs. Conclusion: IOP data obtained during a single visit make for a poor diagnostic tool, no matter whether obtained using nycthemeral measurements or during outpatient hours.

Published
2021

33. 3-year results of the German nationwide survey on eye injuries caused by fireworks

Author

Gabel-Pfisterer, A., Boehringer, D., Agostini, H., Fuest, M., Walter, P., Botros, Y., Mueller, A., Al-Ashi, N., Lenglinger, M., Mueller, B., Schoenfeld, S., Seibel, I., Joussen, A., Breuss, H., Kuchenbecker, J., Foerster, M. H., Berthold, A., Wirbelauer, C., Hofmayer, H., Wachtlin, J., Palka, K., Niemeyer, M., Walla, T., Pham, D., Aisenbrey, S., Tatsiou, A., Walch, A., Burk, R., Schultz, T., Tsiampalis, N., Rehmann, J., Sliwowska, U., Schojai, M., Schulze, K., Kamguia, N., Wirtz, C., Dick, B., Voelker, D., Wintergerst, M., Pfau, M., Melzer, C., Hoegen, D., Bosch, F., Andresen, J. C., Krohne, T., Holz, F., Kathke, M., Sturm, A., Noske, W., Huebner, T., Brandner, S., Feldmann, M., Morsek, J., Rainer, O., Bartsch, H., Ewald, K., Chankiewitz, E., Siegmund, T., Bohlen, A., Mohr, A., Hecker, J., Strassburger, P., Furashova, O., Engelmann, K., Krieb, A., Emmerich, K., Grajewski, L., Krause, L., Jabur, A., Ruediger, K., Lehmann, F., Sachs, H., Matthee, E., Steindorf, F., Schnitzler, C., Neumann, I., Korbmacher, J., Geerling, G., Doulgkeridis, J., Erhard, J., Dahms-Dowidat, K., Kotiasvili, T., Jagow, B. V., Lieder, A., Blum, M., Westerkemper, H., Boehm, M., Bornfeld, N., Bechrakis, N., Schultheiss, M., Scheider, A., Mueller, M., Kohnen, T., Eckert, T., Eckardt, C., Wisniewska, M., Just, A., Jehle, V., Reinhard, T., Seewald, J., Mais, C., Basiakos, S., Osman, B., Xanthopoulou, E., Friedburg, B., Graef, M., Lorenz, B., Just, U., Naxer, S., Oterendorp, C., Bemme, S., Callizo, J., Feltgen, N., Hoerauf, H., Menges, A., Tost, F., Stahl, A., Huth, A., Viestenz, A., Bertram, P., Skevas, C., Kromer, R., Casagrande, M., Grohmann, C., Mehlan, J., Schindler, P., Spitzer, M., Schargus, M., Eddy, M., Schumacher, S., Keserue, M., Scheler, A., Stemplewitz, B., Schaudig, U., Abou Moulig, W., Framme, C., Rosenthal, A., Hesse, L., Kunz, L., Spira, C., Suffo, S., Seitz, B., Wietstock, G., Augsten, R., Meller, D., Mayer, M., Vanselow, K., Lieb, W., Beutner, A., Effert, R., Ehlken, C., Roider, J., Hueber, A., Cursiefen, K., Schrage, N., Kroeger, M., Viehweg, N., Meier, P., Unterlauft, J. D., Wiedemann, P., Hattenbach, L., Kakkassery, V., Ranjbar, M., Mohi, A., Grisanti, S., Bastron, I., Sarac, S., Kaskel-Paul, S., Stoffelns, B., Schuster, A., Pfeiffer, N., Schulze, S., Praskevas, A., Sekundo, W., Weigel, M., Thieme, H., Wolf, A., Vounotrypidis, E., Priglinger, S., Bechstein, L., Maier, M., Lohmann, C., Haritoglu, C., Alten, F., Eter, N., Klishko, V., Holland, U., Medra, A., Weber, A., Hoeh, H., Schmidbauer, J., RiveraGomez, C., Plantzas, K., Weiss, M., Hille, K., Hoehn, F., Schrader, M., Napholz, A., Tandogan, T., Walter, C., Zuehlsdorff-Uthke, M., Liekfeld, A., Blecha, C., Barth, T., Helbig, H., Juenemann, A., Decker, A., Kuehn, M., Ladewig, M., Lenhard, K., Lackner, B., Gekeler, F., Holzschuh, I., Boden, K. T., Szurmann, P., Faul, D., May-Endres, K., Press, U., Luttke, J., Ziemssen, F., Bartz-Schmidt, U., Cordes, J., Raber, F., Mikielewicz, M., Kammerer, J., Kupferschmid, S., Buchwald, H., Werner, J., Kampmeier, J., Bula, A., Krauss, P., Strzalkowski, P., Hillenkamp, J., Gabel-Pfisterer, A., Boehringer, D., Agostini, H., Fuest, M., Walter, P., Botros, Y., Mueller, A., Al-Ashi, N., Lenglinger, M., Mueller, B., Schoenfeld, S., Seibel, I., Joussen, A., Breuss, H., Kuchenbecker, J., Foerster, M. H., Berthold, A., Wirbelauer, C., Hofmayer, H., Wachtlin, J., Palka, K., Niemeyer, M., Walla, T., Pham, D., Aisenbrey, S., Tatsiou, A., Walch, A., Burk, R., Schultz, T., Tsiampalis, N., Rehmann, J., Sliwowska, U., Schojai, M., Schulze, K., Kamguia, N., Wirtz, C., Dick, B., Voelker, D., Wintergerst, M., Pfau, M., Melzer, C., Hoegen, D., Bosch, F., Andresen, J. C., Krohne, T., Holz, F., Kathke, M., Sturm, A., Noske, W., Huebner, T., Brandner, S., Feldmann, M., Morsek, J., Rainer, O., Bartsch, H., Ewald, K., Chankiewitz, E., Siegmund, T., Bohlen, A., Mohr, A., Hecker, J., Strassburger, P., Furashova, O., Engelmann, K., Krieb, A., Emmerich, K., Grajewski, L., Krause, L., Jabur, A., Ruediger, K., Lehmann, F., Sachs, H., Matthee, E., Steindorf, F., Schnitzler, C., Neumann, I., Korbmacher, J., Geerling, G., Doulgkeridis, J., Erhard, J., Dahms-Dowidat, K., Kotiasvili, T., Jagow, B. V., Lieder, A., Blum, M., Westerkemper, H., Boehm, M., Bornfeld, N., Bechrakis, N., Schultheiss, M., Scheider, A., Mueller, M., Kohnen, T., Eckert, T., Eckardt, C., Wisniewska, M., Just, A., Jehle, V., Reinhard, T., Seewald, J., Mais, C., Basiakos, S., Osman, B., Xanthopoulou, E., Friedburg, B., Graef, M., Lorenz, B., Just, U., Naxer, S., Oterendorp, C., Bemme, S., Callizo, J., Feltgen, N., Hoerauf, H., Menges, A., Tost, F., Stahl, A., Huth, A., Viestenz, A., Bertram, P., Skevas, C., Kromer, R., Casagrande, M., Grohmann, C., Mehlan, J., Schindler, P., Spitzer, M., Schargus, M., Eddy, M., Schumacher, S., Keserue, M., Scheler, A., Stemplewitz, B., Schaudig, U., Abou Moulig, W., Framme, C., Rosenthal, A., Hesse, L., Kunz, L., Spira, C., Suffo, S., Seitz, B., Wietstock, G., Augsten, R., Meller, D., Mayer, M., Vanselow, K., Lieb, W., Beutner, A., Effert, R., Ehlken, C., Roider, J., Hueber, A., Cursiefen, K., Schrage, N., Kroeger, M., Viehweg, N., Meier, P., Unterlauft, J. D., Wiedemann, P., Hattenbach, L., Kakkassery, V., Ranjbar, M., Mohi, A., Grisanti, S., Bastron, I., Sarac, S., Kaskel-Paul, S., Stoffelns, B., Schuster, A., Pfeiffer, N., Schulze, S., Praskevas, A., Sekundo, W., Weigel, M., Thieme, H., Wolf, A., Vounotrypidis, E., Priglinger, S., Bechstein, L., Maier, M., Lohmann, C., Haritoglu, C., Alten, F., Eter, N., Klishko, V., Holland, U., Medra, A., Weber, A., Hoeh, H., Schmidbauer, J., RiveraGomez, C., Plantzas, K., Weiss, M., Hille, K., Hoehn, F., Schrader, M., Napholz, A., Tandogan, T., Walter, C., Zuehlsdorff-Uthke, M., Liekfeld, A., Blecha, C., Barth, T., Helbig, H., Juenemann, A., Decker, A., Kuehn, M., Ladewig, M., Lenhard, K., Lackner, B., Gekeler, F., Holzschuh, I., Boden, K. T., Szurmann, P., Faul, D., May-Endres, K., Press, U., Luttke, J., Ziemssen, F., Bartz-Schmidt, U., Cordes, J., Raber, F., Mikielewicz, M., Kammerer, J., Kupferschmid, S., Buchwald, H., Werner, J., Kampmeier, J., Bula, A., Krauss, P., Strzalkowski, P., and Hillenkamp, J.

Abstract

Background On festive days worldwide eyes are severely injured by fireworks. The data on the number and severity are to date not registered in Germany. Objective How frequent are firework-induced injuries in Germany, who are the affected, how serious are the injuries, which forms of treatment are necessary and how frequent are accompanying injuries? Method A German nationwide online-based survey was carried out in all inpatient eye departments and data over the last 3 consecutive years were descriptively analyzed. Results From New Years Eve 2016/2017, when 41 eye departments sent in data, the participation could be increased to 51 eye departments in 2018/2019. More than one third (33-39%) of all 1356 patients over 3 years were minors, 60% were younger than 25 years old and roughly 60% of patients were injured as bystanders or in an unclear situation. In total 25% of all eye injuries were considered severe and required inpatient treatment. Accompanying injuries of the other eye, the face and hands were more frequent in minors than in adults. Eyeball ruptures were reported in 10 minors and 38 adults over the 3 years. Conclusion Particularly minors and bystanders need better protection.

Published
2019

35. Ein retinologisches Therapiekonzept für das dekompensierte Neovaskularisationsglaukom

Author

Hillenkamp, J, Ach, T, Göbel, W, Rosentreter, A, and Strzalkowski, P

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Ein Neovaskularisationsglaukom (NVG) hat einen oft deletären Verlauf. Diese fortlaufende konsekutive Fallserie untersucht Wirksamkeit und Sicherheit eines umfassenden chirurgischen Therapieansatzes. Methoden: Alle Augen mit dekompensiertem NVG (intraokularer Druck IOP, >21[zum vollständigen Text gelangen Sie über die oben angegebene URL], 31. Jahrestagung der Retinologischen Gesellschaft

Published
2018
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36. Vitrectomy with or without encircling band for pseudophakic retinal detachment: a multi-centre, three-arm, randomised clinical trial. VIPER Study Report No. 1—design and enrolment

Author

Mazinani, Babac Arisa Ebrahim, Baumgarten, Sabine, Schiller, P., Agostini, H., Helbig, H., Limburg, E., Hellmich, M., Walter, Peter, VIPER Study Group, Aisenbrey, S., Bartz-Schmidt, Karl Ulrich, Bornfeld, N., Clemens, C., Dahlke, C., Eter, N., Fauser, S., Feltgen, N., Gamulescu, M. A., Gök, M., Hillenkamp, J., Holz, F., Jochmann, C., Joussen, A., Junker, B., Kirchhof, B., Lappas, A., Lommatzsch, A., Lüke, M., Mazinani, B., Meier, P., Neß, T., Nestler, A., Partsch, M., Pielen, A., Rasche, W., Ritzau-Tondrow, U., Rössler, G., Roider, J., Rudolf, M., Uhlig, C., Walter, A., Wiedemann, P., Pfeiffer, A., and Weiß, C.

Subjects
Adult, Male, medicine.medical_specialty, Visual acuity, Pseudophakia, medicine.medical_treatment, Visual Acuity, Vitrectomy, Retina, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Ophthalmology, Treatment Surgery, medicine, Clinical endpoint, Humans, Prospective Studies, Prospective cohort study, business.industry, Patient Selection, Retinal Detachment, Retinal detachment, Clinical Science, medicine.disease, Sensory Systems, Surgery, Clinical trial, Scleral Buckling, Research Design, 030221 ophthalmology & optometry, Female, medicine.symptom, business, Vitreous base, 030217 neurology & neurosurgery, Ophthalmologic Surgical Procedure
Abstract

British journal of ophthalmology : BJO 100(3), 405-410 (2016). doi:10.1136/bjophthalmol-2015-306732, Published by BMJ Publ. Group, London

Published
2015

37. Hochaufgelöste Darstellung autofluoreszierender Granula von RPE-Zellen: Grundlage für detaillierte intrazelluläre Analysen

Author

Ach, Thomas, Hong, S., Heintzmann, R., Hillenkamp, J., Curcio, C.A., Gerig, G., and Bermond, K.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Die intrazelluläre Anreicherung autofluoreszierender Granula (Lipofuszin LF, Melanolipofuszin MLF, Melanosomen M) in Zellen des humanen retinalen Pigmentepithels (RPE) lässt sich zeitlebens nachweisen und histologisch darstellen. Eine hochauflösende mikroskopische Darstellung[zum vollständigen Text gelangen Sie über die oben angegebene URL], 30. Jahrestagung der Retinologischen Gesellschaft

Published
2017
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38. Supplementary Material for: Thinning of Inner Retinal Layers after Vitrectomy with Silicone Oil versus Gas Endotamponade in Eyes with Macula-Off Retinal Detachment

Author

Purtskhvanidze, K., Hillenkamp, J., Tode, J., Junge, O., Hedderich, J., Roider, J., and Treumer, F.

Subjects
genetic structures, sense organs, eye diseases
Abstract

Purpose: To evaluate retinal layer thickness with optical coherence tomography (OCT) in eyes with macula-off retinal detachment after silicone oil (SiO) or gas endotamponade. Procedures: Cross-sectional study of 40 eyes with macula-off rhegmatogenous retinal detachment that underwent vitrectomy. 20 eyes received SiO tamponade and 20 matched eyes received gas. 33 healthy fellow eyes served as controls. Macular spectral domain OCT was performed with automated layer detection in the 5 inner subfields of the Early Treatment Diabetic Retinopathy Study (ETDRS) map. Results: Comparing the SiO group with the gas group, the ganglion cell layer showed a significant thinning in all fields of the inner ring of the ETDRS map, the inner plexiform layer in the nasal, superior and temporal quadrants, and the outer plexiform layer in the nasal quadrant. Conclusions: Inner retinal layers in the fovea/parafovea were significantly thinner in the SiO group. Prospective studies are warranted to further elucidate possible retinal adverse effects of SiO tamponade.

Published
2017
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40. Makulachirurgie: Langzeitverlauf und histologische Analyse

Author

Hillenkamp, J

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Nach Makulachirurgie bei idiopathischer epiretinaler Membran (IEM) und bei durchgreifendem Makulaforamen wurde der best-korrigierte Fernvisus erhoben. Mit hochauflösender optischer Kohärenztomographie (OCT) wurde die foveale Mikrostruktur untersucht und die Dicke der einzelnen Netzhautschichten[zum vollständigen Text gelangen Sie über die oben angegebene URL], Jahrestagung der Vereinigung Bayerischer Augenärzte BayOG 2016|49. Weihnachtssitzung der Münchner Ophthalmologischen Gesellschaft MOG 2016

Published
2016
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41. Erste Ergebnisse therapeutischer Hydrogele als Alternative zur Amnionmembrantransplantation bei kornealer Wundheilungsstörung

Author

Tarau, I.-S., Lotz, C., Groeber, F., Lorson, T., Luxenhofer, R., Walles, H., and Hillenkamp, J.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Wundheilungsstörungen der Kornea sind ein schwerwiegendes klinisches Problem. Der derzeitige klinische Goldstandard ist die Amnionmembrantransplantation. Der Erfolg dieser Therapie ist jedoch von Verfügbarkeit und Qualität des Spendergewebes abhängig. Ziel dieser Studie[zum vollständigen Text gelangen Sie über die oben angegebene URL], Jahrestagung der Vereinigung Bayerischer Augenärzte BayOG 2016|49. Weihnachtssitzung der Münchner Ophthalmologischen Gesellschaft MOG 2016

Published
2016

47. Einfluss der Thermischen Stimulationstherapie der Retina (TS-R) auf die Sekretion von Zellmediatoren

Author

Richert, E, Koinzer, S, Klettner, A, Brinkmann, R, Hillenkamp, J, and Roider, J

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Es wurde der Einfluss der TS-R auf AMD-relevante Zellmediatoren wie Matrixmetalloproteasen (MMPs), der Pigment Epithelium Derived Factor (PEDF) und Vascular Endothelial Growth Factor (VEGF), nach Behandlung mit unterschiedlichen Spotgrößen, untersucht. Methodik: Porcine Explantate[zum vollständigen Text gelangen Sie über die oben angegebene URL], 66. Tagung der Vereinigung Norddeutscher Augenärzte

Published
2016
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48. As the bright light dims: loss of lipofuscin-attributable autofluorescence from RPE in aging and AMD

Author

Ach, T, Smith, RT, Ablonczy, Z, Hillenkamp, J, Heintzmann, R, Sloan, KR, and Curcio, CA

Subjects
ddc: 610, genetic structures, sense organs, 610 Medical sciences, Medicine, eye diseases
Abstract

Background: In healthy persons, fundus autofluorescence (AF) intensity diminishes after age 70 [ref:1], with the underlying mechanisms still unknown. In age-related macular degeneration (AMD), hypoautofluorescent areas in fundus AF-imaging are often referred to as retinal pigment epithelium[for full text, please go to the a.m. URL], VI. International Symposium on AMD – Age-Related Macular Degeneration – Emerging Concepts – Exploring known and Identifying new Pathways

Published
2015
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49. Einfluss der selektiven Retina-Lasertherapie (SRT) auf Zellmediatoren

Author

Richert, E, Koinzer, S, Hillenkamp, J, Roider, J, and Klettner, A

Subjects
ddc: 610, sense organs, 610 Medical sciences, Medicine
Abstract

Einleitung: Es wurde der Einfluss der SRT-Laserbehandlung auf AMD-relevante Mediatoren wie Matrixmetalloproteasen (MMPs), Vascular Endothelial Growth Factor (VEGF) und Pigment Epithelium Derived Factor (PEDF) unter Verwendung unterschiedlicher Läsionsgrößen untersucht. Methodik: Porcine[for full text, please go to the a.m. URL], 65. Tagung der Vereinigung Norddeutscher Augenärzte

Published
2015
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