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432 results on '"Hille B"'

1. RWD87 Retrospective Observational Study of Patients with Metastatic Merkel Cell Carcinoma (mMCC) Using the Caraderm Database Linked to the French National Health Data System (SNDS)

Author

Blom, A., primary, Mortier, L., additional, Kachaner, I., additional, Luciani, L., additional, Cahuzac, C., additional, Van Hille, B., additional, Solbes, M.N., additional, Maillard, C., additional, Bahnini, S., additional, Miotti, H., additional, and Saiag, P., additional

Published
2023
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2. Avélumab en traitement de 1re ligne des patients atteints d’un carcinome à cellules de Merkel métastatique : analyse des données en vie réelle en France à partir de bases de données de cancers rares et du Système National de Données de Santé (SNDS)

Author

Blom, A., Mortier, L., van Hille, B., Pagès, C., Samimi, M., Luciani, L., Cahuzac, C., Robert, C., Quéreux, G., Maubec, E., Maillard, C., Miotti, H., Aubin, F., Arnault, J.P., Dompmartin, A., Mansard, S., Dereure, O., Montaudié, H., Amini-Adle, M., Viguier, M., Kramkimel, N., Granel-Brocard, F., Gaudy-Marqueste, C., Zehou, O., Jeudy, G., Bernard, P., De Quatrebarbes, J., Leccia, M.T., Le Corre, Y., Beneton, N., Wierzbicka-Hainaut, E., Brunet Possenti, F., Lenormand, C., Solbes, M.N., Duval-Modeste, A.B., Kachaner, I., Lebbé, C., Dutriaux, C., and Saiag, P.

Published
2023
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4. O-113 Effectiveness and treatment cost of assisted reproduction technology for women stimulated by gonadotropin in France: A cohort study using the National Health Database

Author

Benchaib, M, primary, Grynberg, M, additional, Cedrin-Durnerin, I, additional, Raguideau, F, additional, Lennon, H, additional, Castello-Bridoux, C, additional, Paillet, S, additional, Porte, F, additional, Verpillat, P, additional, Van Hille, B, additional, Schwarze, J E, additional, and Borget, I, additional

Published
2021
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11. Avélumab en traitement de 1religne des patients atteints d’un carcinome à cellules de Merkel métastatique : analyse des données en vie réelle en France à partir de bases de données de cancers rares et du Système National de Données de Santé (SNDS)

Author

Blom, A., Mortier, L., van Hille, B., Pagès, C., Samimi, M., Luciani, L., Cahuzac, C., Robert, C., Quéreux, G., Maubec, E., Maillard, C., Miotti, H., Aubin, F., Arnault, J.P., Dompmartin, A., Mansard, S., Dereure, O., Montaudié, H., Amini-Adle, M., Viguier, M., Kramkimel, N., Granel-Brocard, F., Gaudy-Marqueste, C., Zehou, O., Jeudy, G., Bernard, P., De Quatrebarbes, J., Leccia, M.T., Le Corre, Y., Beneton, N., Wierzbicka-Hainaut, E., Brunet Possenti, F., Lenormand, C., Solbes, M.N., Duval-Modeste, A.B., Kachaner, I., Lebbé, C., Dutriaux, C., and Saiag, P.

Abstract

Le carcinome à cellules de Merkel (CCM) est un cancer neuroendocrine cutané primitif rare et agressif. L’arrivée des immunothérapies a permis d’améliorer le pronostic. L’avélumab, un anticorps anti–PD-L1, a obtenu une AMM en Europe en septembre 2017 dans le traitement du mCCM à stade III non réséquable ou IV sur la base des résultats de l’essai pivot de phase 2 JAVELIN Merkel 200. La Commission de la transparence a demandé la mise en place d’un registre exhaustif recensant et décrivant tous les patients traités par avélumab en France. L’objectif ici est de présenter des données de vie réelle de patients avec mMCC traités en 1religne (1L) par avélumab.

Published
2023
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12. Proximal clustering between BK and Cav1.3 channels promotes functional coupling and BK channel activation at low voltage

Author

Vivas, O, Moreno, CM, Santana, LF, and Hille, B

Abstract

© Vivas et al. CaV-channel dependent activation of BK channels is critical for feedback control of both calcium influx and cell excitability. Here we addressed the functional and spatial interaction between BK and CaV1.3 channels, unique CaV1 channels that activate at low voltages. We found that when BK and CaV1.3 channels were co-expressed in the same cell, BK channels started activating near 50 mV, ~30 mV more negative than for activation of co-expressed BK and high-voltage activated CaV2.2 channels. In addition, single-molecule localization microscopy revealed striking clusters of CaV1.3 channels surrounding clusters of BK channels and forming a multi-channel complex both in a heterologous system and in rat hippocampal and sympathetic neurons. We propose that this spatial arrangement allows tight tracking between local BK channel activation and the gating of CaV1.3 channels at quite negative membrane potentials, facilitating the regulation of neuronal excitability at voltages close to the threshold to fire action potentials.

Published
2017
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14. Injury : State of the Art Report

Author

Weiner, H. L., Arnason, B. G. W., Bauer, H. J., Felgenhauer, K. M. A., Fields, B. N., Gerhard, W. U., Hille, B., Johnson, R. T., Mims, C., Ritchie, J. M., Pappenheimer, A. M., Jr., Sears, T. A., Ter Meulen, V., Waksman, B. H., Bernhard, Silke, editor, and Sears, T. A., editor

Published
1982
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16. Aberglaube

Author

Harmening, D., Schödlbauer, U., Landrock, R., Müller, M., Weyergraf, B., Rytlewski, R., Bleuel, H. P., Körfgen, P., Schnell, R., Müller, B. K., Bolle, M., Grawert-May, E., Tenfelde, K., Pirker, Th., Markmann, H., Gillen, E., Ackermann, M., Kahlenberg, F. P., Kopitzsch, F., v. Engelhardt, M., Schäfer, H.-P., von Kondratowitz, H.-J., Maurer, E., Lehmann, H.-Th., Schulz, G., Hollenstein, E., Hühn, W., Pankoke, E., Skowronek, H., Bintig, A., Gabriel, J., Knopf, J., Arnold, W., Eyssen, J., Seeßlen, G., Schmied, W., Mülhaupt, F., Kröll, F., Franzmann, B., Schweikert, U., Köhler, R., Rucht, D., Fricke, K. W., Häußermann, H. H., Schwarzenbach, R., Pforte, D., Schmitt, H.-J., Fenner, Ch., Beseler, H., Stellmacher, D., Baacke, D., v. Alemann, H., Arens, U., Rossade, W., Best, O. F., Endruweit, G., Wiswede, G., Kutsch, Th., von der Ohe, W., Dräger, H., Waterkamp, D., Wiegelmann, G., Schneider, S., von Kondratowitz, H. J., Hille, B., Hickethier, K., Köstlin, K., Möller, Hildegard, Hömberg, W., Gregor, E. U., Kersten, H., Gaßner, H., Kittsteiner, H. D., Gransow, V., Ibrahim, M., Böckelmann, F., Ziegler, B., Holzweißig, G., Jahn, E., Schulte-Wülwer, U., Hoffmann-Axthelm, D., Möller, Horst, Düßel, R., Lohmann, U., Narr, W.-D., Wilke, M., Greverus, I.-M., Lieber, H.-J., Sembach, K.-J., Sonnenberger, F., Weigand, K. H., Blaum, V., Kuppe, J., Pillau, H., Schönert, J., Hagen, W., Langenbucher, W. R., Jaide, W., Michel, D., Motzkau-Valeton, W., Grünewald, D., Bauer, K. W., Hengst, H., Siefer, G., Lutz, B., v. Bredow, W., v. Ferber, Ch., Maus, C., Spinner, H. F., Richarz, M., v. Beyme, K., Michalsky, H., Jeggle, U., Rüß, G., Lindner, B., Peisert, H., Trommler, F., Glaser, H., Schwenger, H., Becker, H., Lübbe, P., Warneken, B. J., Warneken-Pallowski, K., Thurn, H. P., Kramer, D., Baumhauer, O. A., Osterwold, T., Bussmann, G., v. Wentzel, B., Stänke, H., Spielmann, H., Glatzer, W., Seibel, H. D., Voigt, D., Kühn, G. F., Rodekohr, K., Röttgers, K., Burkhardt, W., Löcher, W., Bosshart, L., Loviscach, P., Markefka, M., de Hipt, M. Opp, Dähn, H., Steiger, H., König, R., Treinen, H., Kühn, H., Mack, D., Schütz, W. W., Sening, Ch., Gruhn, W., Emmerich, W., Schreiber, E., Schmalriede, M., v. Heimburg, S., Duvigneau, V., Muck, M., Keupp, H., Gutzler, H., Sloterdijk, P., Modick, K., Grebing, H., Leitner, O., Dunger, H., Willberg, H. P., Jeschke, W., Hasselblatt, D., Nitzschke, B., Pfister, G., Kaempfert, M., Machule, D., Wittwer, W., zur Lippe, R., Huning, A., Kreidt, D., Peitsch, H., Meyer-Clason, C., Raschke, P., Holtz, C., Klages, H., Burrichter, C., Lipp, M., Blume, A., Wendorff, R., Wilke, J., v. Blücher, G., Kleemann, G., Winter, M., Langenbucher, Wolfgang R., editor, Rytlewski, Ralf, editor, and Weyergraf, Bernd, editor

Published
1983
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25. Aberglaube

Author

Harmening, D., primary, Schödlbauer, U., additional, Landrock, R., additional, Müller, M., additional, Weyergraf, B., additional, Rytlewski, R., additional, Bleuel, H. P., additional, Körfgen, P., additional, Schnell, R., additional, Müller, B. K., additional, Bolle, M., additional, Grawert-May, E., additional, Tenfelde, K., additional, Pirker, Th., additional, Markmann, H., additional, Gillen, E., additional, Ackermann, M., additional, Kahlenberg, F. P., additional, Kopitzsch, F., additional, v. Engelhardt, M., additional, Schäfer, H.-P., additional, von Kondratowitz, H.-J., additional, Maurer, E., additional, Lehmann, H.-Th., additional, Schulz, G., additional, Hollenstein, E., additional, Hühn, W., additional, Pankoke, E., additional, Skowronek, H., additional, Bintig, A., additional, Gabriel, J., additional, Knopf, J., additional, Arnold, W., additional, Eyssen, J., additional, Seeβlen, G., additional, Schmied, W., additional, Mülhaupt, F., additional, Kröll, F., additional, Franzmann, B., additional, Schweikert, U., additional, Köhler, R., additional, Rucht, D., additional, Fricke, K. W., additional, Häuβermann, H. H., additional, Schwarzenbach, R., additional, Pforte, D., additional, Schmitt, H.-J., additional, Fenner, Ch., additional, Beseler, H., additional, Stellmacher, D., additional, Baacke, D., additional, v. Alemann, H., additional, Arens, U., additional, Rossade, W., additional, Endruweit, G., additional, Wiswede, G., additional, Kutsch, Th., additional, von der Ohe, W., additional, Dräger, H., additional, Waterkamp, D., additional, Wiegelmann, G., additional, Schneider, S., additional, Hille, B., additional, Hickethier, K., additional, Köstlin, K., additional, Möller, Hildegard, additional, Hömberg, W., additional, Gregor, E. U., additional, Kersten, H., additional, Gagner, H., additional, Kittsteiner, H. D., additional, Gransow, V., additional, Ibrahim, M., additional, Böckelmann, F., additional, Ziegler, B., additional, Holzweiβig, G., additional, Jahn, E., additional, Schulte-Wülwer, U., additional, Hoffmann-Axthelm, D., additional, Möller, Horst, additional, Düβel, R., additional, Lohmann, U., additional, Narr, W.-D., additional, Wilke, M., additional, Greverus, I.-M., additional, Lieber, H.-J., additional, Sembach, K.-J., additional, Sonnenberger, F., additional, Weigand, K. H., additional, Blaum, V., additional, Kuppe, J., additional, Pillau, H., additional, Hagen, W., additional, Langenbucher, W. R., additional, Blauur, V., additional, Jaide, W., additional, Michel, D., additional, Motzkau-Yaleton, W., additional, Grünewald, D., additional, Bauer, K. W., additional, Hengst, H., additional, Siefer, G., additional, Lutz, B., additional, v. Bredow, W., additional, v. Ferber, Ch., additional, Maus, C., additional, Spinner, H. F., additional, Richarz, M., additional, v. Beyme, K., additional, Michalsky, H., additional, Jeggle, U., additional, Riiβ, G., additional, Lindner, B., additional, Peisert, H., additional, Trommler, F., additional, Glaser, H., additional, Schwenger, H., additional, Becker, H., additional, Lübbe, P., additional, Warneken, B. J., additional, Warneken-Pallowski, K., additional, Thum, H. P., additional, Kramer, D., additional, Baumhauer, O. A., additional, Thurn, H. P., additional, Osterwold, T., additional, Bussmann, G., additional, Haase, H. E., additional, v. Wentzel, B., additional, Stänke, H., additional, Spielmann, H., additional, Glatzer, W., additional, Seibel, H. D., additional, Voigt, D., additional, Kühn, G. F., additional, Rodekohr, K., additional, Schönert, J., additional, Röstgers, K., additional, Burkhardt, W., additional, Löcher, W., additional, Bosshart, L., additional, Loviscach, P., additional, Markefka, M., additional, de Hipt, M. Opp, additional, Dähn, H., additional, Steiger, H., additional, König, R., additional, Treinen, H., additional, Mack, D., additional, Schütz, W. W., additional, Sening, Ch., additional, Gruhn, W., additional, Emmerich, W., additional, Schreiber, E., additional, Wolf, H. E., additional, Schmalriede, M., additional, Gaβner, H., additional, v. Heimburg, S., additional, Duvigneau, V., additional, Muck, M., additional, Keupp, H., additional, Gutzler, H., additional, Sloterdijk, P., additional, Modick, K., additional, Grebing, H., additional, Leitner, O., additional, Dunger, H., additional, Willberg, H. P., additional, Schafer, H.-P., additional, Jeschke, W., additional, Hasselblatt, D., additional, Diiβel, R., additional, Nitzschke, B., additional, Pfister, G., additional, Kaempfert, M., additional, Machule, D., additional, Wittwer, W., additional, zur Lippe, R., additional, Huning, A., additional, Kreidt, D., additional, Peitsch, H., additional, Meyer-Clason, C., additional, Seeelen, G., additional, Raschke, P., additional, Holtz, C., additional, Klages, H., additional, Burrichter, C., additional, Lipp, M., additional, Blume, A., additional, Wendoiff, R., additional, v. Blücher, G., additional, Kleemann, G., additional, and Winter, M., additional

Published
1988
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26. Injury

Author

Weiner, H. L., primary, Arnason, B. G. W., additional, Bauer, H. J., additional, Felgenhauer, K. M. A., additional, Fields, B. N., additional, Gerhard, W. U., additional, Hille, B., additional, Johnson, R. T., additional, Mims, C., additional, Ritchie, J. M., additional, Pappenheimer, A. M., additional, Sears, T. A., additional, Ter Meulen, V., additional, and Waksman, B. H., additional

Published
1982
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27. Fortsetzung von Familien Fuchs'scher Differenzialgleichungen bei Kompaktifizierungen ihrer Parameterräume

Author

Hille, B. (Björn), Hamm, H.A. (Helmut), and Universitäts- und Landesbibliothek Münster

Subjects
gewöhnliche Differentialgleichungen mit Parametern, Fuchs'sche Differentialgleichungen, Gröbner-Basen, konfluente hypergeometrische Differentialgleichung, Kompaktifizierung, ddc:510, Mathematics
Abstract

Ziel dieser Arbeit ist es, den Parameterraum einer gegebenen Familie Fuchs'scher Differenzialgleichungen zu kompaktifizieren und die Familie fortzusetzen. Hierzu wird der Parameterraum formal erweitert, indem der Familie ein Graph in einem affinen Raum zugeordnet und im kartesischen Produkt zweier gewichtet-projektiver Räume abgeschlossen wird. Durch Projektion dieser bi-quasi-homogenen Varietät lassen sich die über dem unendlich fernen Teil des Parameterraums entstehenden Differenzialgleichungen ermitteln. Ein wesentliches Hilfsmittel bei der Berechnung sind Gröbner-Basen von Idealen. Unter anderem wird gezeigt, wie mit Hilfe solcher Gröbner-Basen Ideale bi-quasi-homogenisiert werden können. Unter Einsatz des Computer-Algebra-Programms "Singular" wird das beschriebene Verfahren exemplarisch auf die (transformierte) hypergeometrische Differenzialgleichung sowie auf die volle Familie Fuchs'scher Differenzialgleichungen zweiter Ordnung mit zwei endlichen Singularitäten angewendet.

Published
2005

30. mRNA expression, measured by quantitative reverse transcriptase polymerase chain reaction, of five putative drug resistance parameters, in normal and leukaemic peripheral blood and bone marrow

Author

van Hille B, André Tichelli, A Lohri, Richard Herrmann, and J Reuter

Subjects
Adult, Male, Drug Resistance, Gene Expression, Quantitative Reverse Transcriptase PCR, Drug resistance, Biology, Polymerase Chain Reaction, law.invention, law, Bone Marrow, Gene expression, medicine, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, RNA, Messenger, Gene, Polymerase chain reaction, Aged, Glutathione Transferase, Messenger RNA, RNA-Directed DNA Polymerase, Hematology, General Medicine, Middle Aged, Molecular biology, Leukemia, Myeloid, Acute, medicine.anatomical_structure, DNA Topoisomerases, Type II, Proto-Oncogene Proteins c-bcl-2, Female, Bone marrow, Genes, MDR
Abstract

Using a quantitative reverse transcriptase PCR assay, the mRNA expression of five putative drug resistance-related genes were assessed in normal peripheral (n = 14) and bone marrow (n = 4) mononuclear cells from healthy donors and patients with acute myeloid leukaemia (n = 11). The mRNA levels of MDR1, the multidrug resistance-associated protein and glutathione-S-transferase pi were equally expressed in both compartments. Bcl-2 mRNA was slightly higher in the leukaemic marrow samples. However, topoisomerase II alpha mRNA levels were found to be much higher in normal and leukaemic marrow cells compared to peripheral blood (p0.01), which may, in part, reflect the different proliferation pattern of the mononuclear cells in the two compartments. Such findings could be important for researchers using bulk assays in a mix of samples from peripheral blood or bone marrow to investigate prognostic factors in patients with leukaemia.

Published
1997

31. Climate Change and the Integrity of Science

Author

Gleick, P. H., primary, Adams, R. M., additional, Amasino, R. M., additional, Anders, E., additional, Anderson, D. J., additional, Anderson, W. W., additional, Anselin, L. E., additional, Arroyo, M. K., additional, Asfaw, B., additional, Ayala, F. J., additional, Bax, A., additional, Bebbington, A. J., additional, Bell, G., additional, Bennett, M. V. L., additional, Bennetzen, J. L., additional, Berenbaum, M. R., additional, Berlin, O. B., additional, Bjorkman, P. J., additional, Blackburn, E., additional, Blamont, J. E., additional, Botchan, M. R., additional, Boyer, J. S., additional, Boyle, E. A., additional, Branton, D., additional, Briggs, S. P., additional, Briggs, W. R., additional, Brill, W. J., additional, Britten, R. J., additional, Broecker, W. S., additional, Brown, J. H., additional, Brown, P. O., additional, Brunger, A. T., additional, Cairns, J., additional, Canfield, D. E., additional, Carpenter, S. R., additional, Carrington, J. C., additional, Cashmore, A. R., additional, Castilla, J. C., additional, Cazenave, A., additional, Chapin, F. S., additional, Ciechanover, A. J., additional, Clapham, D. E., additional, Clark, W. C., additional, Clayton, R. N., additional, Coe, M. D., additional, Conwell, E. M., additional, Cowling, E. B., additional, Cowling, R. M., additional, Cox, C. S., additional, Croteau, R. B., additional, Crothers, D. M., additional, Crutzen, P. J., additional, Daily, G. C., additional, Dalrymple, G. B., additional, Dangl, J. L., additional, Darst, S. A., additional, Davies, D. R., additional, Davis, M. B., additional, de Camilli, P. V., additional, Dean, C., additional, Defries, R. S., additional, Deisenhofer, J., additional, Delmer, D. P., additional, Delong, E. F., additional, Derosier, D. J., additional, Diener, T. O., additional, Dirzo, R., additional, Dixon, J. E., additional, Donoghue, M. J., additional, Doolittle, R. F., additional, Dunne, T., additional, Ehrlich, P. R., additional, Eisenstadt, S. N., additional, Eisner, T., additional, Emanuel, K. A., additional, Englander, S. W., additional, Ernst, W. G., additional, Falkowski, P. G., additional, Feher, G., additional, Ferejohn, J. A., additional, Fersht, A., additional, Fischer, E. H., additional, Fischer, R., additional, Flannery, K. V., additional, Frank, J., additional, Frey, P. A., additional, Fridovich, I., additional, Frieden, C., additional, Futuyma, D. J., additional, Gardner, W. R., additional, Garrett, C. J. R., additional, Gilbert, W., additional, Goldberg, R. B., additional, Goodenough, W. H., additional, Goodman, C. S., additional, Goodman, M., additional, Greengard, P., additional, Hake, S., additional, Hammel, G., additional, Hanson, S., additional, Harrison, S. C., additional, Hart, S. R., additional, Hartl, D. L., additional, Haselkorn, R., additional, Hawkes, K., additional, Hayes, J. M., additional, Hille, B., additional, Hokfelt, T., additional, House, J. S., additional, Hout, M., additional, Hunten, D. M., additional, Izquierdo, I. A., additional, Jagendorf, A. T., additional, Janzen, D. H., additional, Jeanloz, R., additional, Jencks, C. S., additional, Jury, W. A., additional, Kaback, H. R., additional, Kailath, T., additional, Kay, P., additional, Kay, S. A., additional, Kennedy, D., additional, Kerr, A., additional, Kessler, R. C., additional, Khush, G. S., additional, Kieffer, S. W., additional, Kirch, P. V., additional, Kirk, K., additional, Kivelson, M. G., additional, Klinman, J. P., additional, Klug, A., additional, Knopoff, L., additional, Kornberg, H., additional, Kutzbach, J. E., additional, Lagarias, J. C., additional, Lambeck, K., additional, Landy, A., additional, Langmuir, C. H., additional, Larkins, B. A., additional, Le Pichon, X. T., additional, Lenski, R. E., additional, Leopold, E. B., additional, Levin, S. A., additional, Levitt, M., additional, Likens, G. E., additional, Lippincott-Schwartz, J., additional, Lorand, L., additional, Lovejoy, C. O., additional, Lynch, M., additional, Mabogunje, A. L., additional, Malone, T. F., additional, Manabe, S., additional, Marcus, J., additional, Massey, D. S., additional, McWilliams, J. C., additional, Medina, E., additional, Melosh, H. J., additional, Meltzer, D. J., additional, Michener, C. D., additional, Miles, E. L., additional, Mooney, H. A., additional, Moore, P. B., additional, Morel, F. M. M., additional, Mosley-Thompson, E. S., additional, Moss, B., additional, Munk, W. H., additional, Myers, N., additional, Nair, G. B., additional, Nathans, J., additional, Nester, E. W., additional, Nicoll, R. A., additional, Novick, R. P., additional, O'Connell, J. F., additional, Olsen, P. E., additional, Opdyke, N. D., additional, Oster, G. F., additional, Ostrom, E., additional, Pace, N. R., additional, Paine, R. T., additional, Palmiter, R. D., additional, Pedlosky, J., additional, Petsko, G. A., additional, Pettengill, G. H., additional, Philander, S. G., additional, Piperno, D. R., additional, Pollard, T. D., additional, Price, P. B., additional, Reichard, P. A., additional, Reskin, B. F., additional, Ricklefs, R. E., additional, Rivest, R. L., additional, Roberts, J. D., additional, Romney, A. K., additional, Rossmann, M. G., additional, Russell, D. W., additional, Rutter, W. J., additional, Sabloff, J. A., additional, Sagdeev, R. Z., additional, Sahlins, M. D., additional, Salmond, A., additional, Sanes, J. R., additional, Schekman, R., additional, Schellnhuber, J., additional, Schindler, D. W., additional, Schmitt, J., additional, Schneider, S. H., additional, Schramm, V. L., additional, Sederoff, R. R., additional, Shatz, C. J., additional, Sherman, F., additional, Sidman, R. L., additional, Sieh, K., additional, Simons, E. L., additional, Singer, B. H., additional, Singer, M. F., additional, Skyrms, B., additional, Sleep, N. H., additional, Smith, B. D., additional, Snyder, S. H., additional, Sokal, R. R., additional, Spencer, C. S., additional, Steitz, T. A., additional, Strier, K. B., additional, Sudhof, T. C., additional, Taylor, S. S., additional, Terborgh, J., additional, Thomas, D. H., additional, Thompson, L. G., additional, Tjian, R. T., additional, Turner, M. G., additional, Uyeda, S., additional, Valentine, J. W., additional, Valentine, J. S., additional, van Etten, J. L., additional, van Holde, K. E., additional, Vaughan, M., additional, Verba, S., additional, von Hippel, P. H., additional, Wake, D. B., additional, Walker, A., additional, Walker, J. E., additional, Watson, E. B., additional, Watson, P. J., additional, Weigel, D., additional, Wessler, S. R., additional, West-Eberhard, M. J., additional, White, T. D., additional, Wilson, W. J., additional, Wolfenden, R. V., additional, Wood, J. A., additional, Woodwell, G. M., additional, Wright, H. E., additional, Wu, C., additional, Wunsch, C., additional, and Zoback, M. L., additional

Published
2010
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37. Sensitization of transformed rat cells to parvovirus MVMp is restricted to specific oncogenes

Author

Salomé N, van Hille B, Duponchel N, Guerrino Meneguzzi, Cuzin F, Rommelaere J, and Jj, Cornelis

Subjects
DNA Replication, Cell Transformation, Neoplastic, Phenotype, Gene Amplification, Animals, Oncogenes, Simian virus 40, Virus Replication, Parvoviridae, Bovine papillomavirus 1, Rats
Abstract

The rat cell line FR3T3 was transformed with the retroviral oncogenes v-myc or v-src, with the DNA tumor viruses SV40 or bovine papilloma virus strain 1 (BPV-1) or with the 69% transforming region of BPV-1. The transformants were compared with the uncloned parental line for their susceptibility to the lytic effect and to the replication of MVMp, an autonomous parvovirus. Expression of v-myc and v-src proteins and of SV40 large T antigen correlated with a greater cell susceptibility to MVMp-induced killing. Thus, the expression of both cytoplasmic and nuclear oncogene products may sensitize rat fibroblasts to MVMp. In contrast, cell lines transformed by BPV-1, including highly tumorigenic and tumor-derived clones, were on the average as resistant as the parental cell line to MVMp infection. A similar resistance to MVMp-induced killing was displayed by BPV-1-transformed NIH3T3 cells. However, supertransformation of one of the BPV-1-transformants by the human EJ-Harvey ras-1 oncogene, known to sensitize FR3T3 and NIH3T3 cells, correlated with an increase in susceptibility to MVMp. Therefore, the failure of BPV-1 transformation to sensitize murine cells to parvoviral attack may be ascribed to the tumor virus rather than to the cells undergoing transformation. Hence, cell sensitization to MVMp appears to be oncogene-specific and cannot be taken as an absolute correlative with neoplastic transformation.

Published
1990

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