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1. Three Decades of Formal Methods in Business Process Compliance: A Systematic Literature Review

Author

López, Hugo A. and Hildebrandt, Thomas T.

Subjects
Computer Science - Software Engineering, 68N30, D.2.4, D.2.1, H.4
Abstract

Digitalization efforts often face a key challenge: business processes must not only be efficient in achieving their goals but also adhere to legal regulations. Business process compliance refers to aligning processes with these regulations. Numerous frameworks have been developed to address this, with the earliest dating back to 1981. This study focuses on rigorous frameworks using formal methods to verify or ensure compliance. We conducted a systematic literature review (SLR) on process compliance frameworks based on formal models. Our goal was to assess the current state of research on process model compliance and identify gaps and opportunities for future work. Starting with 5018 candidate studies from 1981 to the establishment of GDPR, we selected 46 primary studies. These frameworks were categorized by their phases, the languages used for processes and compliance, and their reasoning techniques. We also examined their practical applicability, the case studies they were tested on, the types of users involved, and the skills needed for compliance. Also, we assessed the maturity of each framework. Our findings reveal strong consensus around verification techniques as central to process compliance, though there is less agreement on the earlier and later phases of compliance. Model checking is the dominant technique, but the compliance and process languages have evolved. Most frameworks are still conceptual with prototype implementations, often failing to account for compliance professionals like legal experts or law changes. In conclusion, there is a need for comprehensive empirical studies to better understand the anatomy and maturity of regulatory compliance frameworks, and for robust evaluation methods to benchmark these frameworks. This review offers valuable insights for researchers and practitioners in process compliance., Comment: 39 pages, 16 Figures, 12 tables

Published
2024

2. Advancing stem cell technologies for conservation of wildlife biodiversity.

Author

Hutchinson, Ashlee M, Appeltant, Ruth, Burdon, Tom, Bao, Qiuye, Bargaje, Rhishikesh, Bodnar, Andrea, Chambers, Stuart, Comizzoli, Pierre, Cook, Laura, Endo, Yoshinori, Harman, Bob, Hayashi, Katsuhiko, Hildebrandt, Thomas, Korody, Marisa L, Lakshmipathy, Uma, Loring, Jeanne F, Munger, Clara, Ng, Alex HM, Novak, Ben, Onuma, Manabu, Ord, Sara, Paris, Monique, Pask, Andrew J, Pelegri, Francisco, Pera, Martin, Phelan, Ryan, Rosental, Benyamin, Ryder, Oliver A, Sukparangsi, Woranop, Sullivan, Gareth, Tay, Nicole Liling, Traylor-Knowles, Nikki, Walker, Shawn, Weberling, Antonia, Whitworth, Deanne J, Williams, Suzannah A, Wojtusik, Jessye, Wu, Jun, Ying, Qi-Long, Zwaka, Thomas P, and Kohler, Timo N

Subjects
In vitro gametogenesis, Biodiversity, Conservation, Disease modelling, IPSC, Stem cells, Animals, Conservation of Natural Resources, Animals, Wild, Stem Cells, Humans, Biological Sciences, Medical and Health Sciences, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Wildlife biodiversity is essential for healthy, resilient and sustainable ecosystems. For biologists, this diversity also represents a treasure trove of genetic, molecular and developmental mechanisms that deepen our understanding of the origins and rules of life. However, the rapid decline in biodiversity reported recently foreshadows a potentially catastrophic collapse of many important ecosystems and the associated irreversible loss of many forms of life on our planet. Immediate action by conservationists of all stripes is required to avert this disaster. In this Spotlight, we draw together insights and proposals discussed at a recent workshop hosted by Revive & Restore, which gathered experts to discuss how stem cell technologies can support traditional conservation techniques and help protect animal biodiversity. We discuss reprogramming, in vitro gametogenesis, disease modelling and embryo modelling, and we highlight the prospects for leveraging stem cell technologies beyond mammalian species.

Published
2024

3. Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts

Author

Ruiz-Orera, Jorge, Miller, Duncan C., Greiner, Johannes, Genehr, Carolin, Grammatikaki, Aliki, Blachut, Susanne, Mbebi, Jeanne, Patone, Giannino, Myronova, Anna, Adami, Eleonora, Dewani, Nikita, Liang, Ning, Hummel, Oliver, Muecke, Michael B., Hildebrandt, Thomas B., Fritsch, Guido, Schrade, Lisa, Zimmermann, Wolfram H., Kondova, Ivanela, Diecke, Sebastian, van Heesch, Sebastiaan, and Hübner, Norbert

Published
2024
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4. Long-term mortality and health-related quality of life with lower versus higher oxygenation targets in intensive care unit patients with COVID-19 and severe hypoxaemia

Author

Crescioli, Elena, Nielsen, Frederik Mølgaard, Bunzel, Anne-Marie, Eriksen, Anne Sofie Broberg, Siegemund, Martin, Poulsen, Lone Musaeus, Andreasen, Anne Sofie, Bestle, Morten Heiberg, Iversen, Susanne Andi, Brøchner, Anne Craveiro, Grøfte, Thorbjørn, Hildebrandt, Thomas, Laake, Jon Henrik, Kjær, Maj-Brit Nørregaard, Lange, Theis, Perner, Anders, Klitgaard, Thomas Lass, Schjørring, Olav Lilleholt, and Rasmussen, Bodil Steen

Published
2024
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5. A Standardized Nomenclature Design for Systematic Referencing and Identification of Animal Cellular Material.

Author

Schrade, Lisa, Mah, Nancy, Bandrowski, Anita, Chen, Ying, Dewender, Johannes, Diecke, Sebastian, Hiepen, Christian, Lancaster, Madeline, Marques-Bonet, Tomas, Martinez, Sira, Mueller, Sabine, Navara, Christopher, Prigione, Alessandro, Seltmann, Stefanie, Sochacki, Jaroslaw, Sutcliffe, Magdalena, Zywitza, Vera, Hildebrandt, Thomas, and Kurtz, Andreas

Subjects
FAIR data, biodiversity, biosample nomenclature, cryobanking, species conservation, standardization, unambiguous identifier, viable cell material, wildlife
Abstract

The documentation, preservation and rescue of biological diversity increasingly uses living biological samples. Persistent associations between species, biosamples, such as tissues and cell lines, and the accompanying data are indispensable for using, exchanging and benefiting from these valuable materials. Explicit authentication of such biosamples by assigning unique and robust identifiers is therefore required to allow for unambiguous referencing, avoid identification conflicts and maintain reproducibility in research. A predefined nomenclature based on uniform rules would facilitate this process. However, such a nomenclature is currently lacking for animal biological material. We here present a first, standardized, human-readable nomenclature design, which is sufficient to generate unique and stable identifying names for animal cellular material with a focus on wildlife species. A species-specific human- and machine-readable syntax is included in the proposed standard naming scheme, allowing for the traceability of donated material and cultured cells, as well as data FAIRification. Only when it is consistently applied in the public domain, as publications and inter-institutional samples and data are exchanged, distributed and stored centrally, can the risks of misidentification and loss of traceability be mitigated. This innovative globally applicable identification system provides a standard for a sustainable structure for the long-term storage of animal bio-samples in cryobanks and hence facilitates current as well as future species conservation and biomedical research.

Published
2024

7. Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals

Author

Liwinski, Timur, Auer, Matthias K., Schröder, Johanna, Pieknik, Ina, Casar, Christian, Schwinge, Dorothee, Henze, Lara, Stalla, Günter K., Lang, Undine E., von Klitzing, Alina, Briken, Peer, Hildebrandt, Thomas, Desbuleux, Jeanne C., Biedermann, Sarah V., Holterhus, Paul-Martin, Bang, Corinna, Schramm, Christoph, and Fuss, Johannes

Published
2024
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9. CLawK: Monitoring Business Processes in Smart Contracts

Author

Eshghie, Mojtaba, Ahrendt, Wolfgang, Artho, Cyrille, Hildebrandt, Thomas Troels, and Schneider, Gerardo

Subjects
Computer Science - Cryptography and Security, Computer Science - Software Engineering
Abstract

Smart contracts embody complex business processes that can be difficult to analyze statically. In this paper, we present CLawK, a runtime monitoring tool that leverages business process specifications written in DCR graphs to provide runtime verification of smart contract execution. We demonstrate how CLawK can detect and flag deviations from specified behaviors in smart contracts deployed in the Ethereum network without code instrumentation and any additional gas costs.

Published
2023

10. Capturing Smart Contract Design with DCR Graphs

Author

Eshghie, Mojtaba, Ahrendt, Wolfgang, Artho, Cyrille, Hildebrandt, Thomas Troels, and Schneider, Gerardo

Subjects
Computer Science - Software Engineering, Computer Science - Computers and Society, Computer Science - Formal Languages and Automata Theory
Abstract

Smart contracts manage blockchain assets and embody business processes. However, mainstream smart contract programming languages such as Solidity lack explicit notions of roles, action dependencies, and time. Instead, these concepts are implemented in program code. This makes it very hard to design and analyze smart contracts. We argue that DCR graphs are a suitable formalization tool for smart contracts because they explicitly and visually capture the mentioned features. We utilize this expressiveness to show that many common high-level design patterns representing the underlying business processes in smart contract applications can be naturally modeled this way. Applying these patterns shows that DCR graphs facilitate the development and analysis of correct and reliable smart contracts by providing a clear and easy-to-understand specification., Comment: Accepted for presentation at SEFM 2023

Published
2023

11. Improving Simplicity by Discovering Nested Groups in Declarative Models

Author

Cosma, Vlad Paul, Christfort, Axel Kjeld Fjelrad, Hildebrandt, Thomas T., Lu, Xixi, Reijers, Hajo A., Slaats, Tijs, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, van Leeuwen, Jan, Series Editor, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Kobsa, Alfred, Series Editor, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Nierstrasz, Oscar, Series Editor, Pandu Rangan, C., Editorial Board Member, Sudan, Madhu, Series Editor, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Weikum, Gerhard, Series Editor, Vardi, Moshe Y, Series Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Guizzardi, Giancarlo, editor, Santoro, Flavia, editor, Mouratidis, Haralambos, editor, and Soffer, Pnina, editor

Published
2024
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12. Developing an AI-enabled IIoT platform -- Lessons learned from early use case validation

Author

Eichelberger, Holger, Palmer, Gregory, Reimer, Svenja, Vu, Tat Trong, Do, Hieu, Laridi, Sofiane, Weber, Alexander, Niederée, Claudia, and Hildebrandt, Thomas

Subjects
Computer Science - Artificial Intelligence, Computer Science - Software Engineering
Abstract

For a broader adoption of AI in industrial production, adequate infrastructure capabilities are crucial. This includes easing the integration of AI with industrial devices, support for distributed deployment, monitoring, and consistent system configuration. Existing IIoT platforms still lack required capabilities to flexibly integrate reusable AI services and relevant standards such as Asset Administration Shells or OPC UA in an open, ecosystem-based manner. This is exactly what our next level Intelligent Industrial Production Ecosphere (IIP-Ecosphere) platform addresses, employing a highly configurable low-code based approach. In this paper, we introduce the design of this platform and discuss an early evaluation in terms of a demonstrator for AI-enabled visual quality inspection. This is complemented by insights and lessons learned during this early evaluation activity., Comment: 16 pages, 5 figures

Published
2022

15. Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)

Author

Anthon, Carl Thomas, Pène, Frédéric, Perner, Anders, Azoulay, Elie, Puxty, Kathryn, Van De Louw, Andry, Barratt-Due, Andreas, Chawla, Sanjay, Castro, Pedro, Póvoa, Pedro, Coelho, Luis, Metaxa, Victoria, Kochanek, Matthias, Liebregts, Tobias, Kander, Thomas, Hästbacka, Johanna, Andreasen, Jo Bønding, Péju, Edwige, Nielsen, Lene Bjerregaard, Hvas, Christine Lodberg, Dufranc, Etienne, Canet, Emmanuel, Lundqvist, Linda, Wright, Christopher John, Schmidt, Julien, Uhel, Fabrice, Ait-Oufella, Hafid, Krag, Mette, Cos Badia, Elisabet, Díaz-Lagares, Cándido, Menat, Sophie, Voiriot, Guillaume, Clausen, Niels Erikstrup, Lorentzen, Kristian, Kvåle, Reidar, Hildebrandt, Thomas, Holten, Aleksander Rygh, Strand, Kristian, Tzalavras, Asterios, Bestle, Morten Heiberg, Klepstad, Pål, Fernandez, Sara, Vimpere, Damien, Paulino, Carolina, Graça, Carina, Lueck, Catherina, Juhl, Christian Svendsen, Costa, Carolina, Bådstøløkken, Per Martin, Miranda, Teresa, Lêdo, Lia Susana Aires, Sousa Torres, Joao Carlos, Granholm, Anders, Møller, Morten Hylander, and Russell, Lene

Published
2023
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16. Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock

Author

Kjær, Maj-Brit Nørregaard, Meyhoff, Tine Sylvest, Sivapalan, Praleene, Granholm, Anders, Hjortrup, Peter Buhl, Madsen, Martin Bruun, Møller, Morten Hylander, Egerod, Ingrid, Wetterslev, Jørn, Lange, Theis, Cronhjort, Maria, Laake, Jon Henrik, Jakob, Stephan M., Nalos, Marek, Ostermann, Marlies, Gould, Doug, Cecconi, Maurizio, Malbrain, Manu L. N. G., Ahlstedt, Christian, Kiel, Louise Bendix, Bestle, Morten H., Nebrich, Lars, Hildebrandt, Thomas, Russell, Lene, Vang, Marianne, Rasmussen, Michael Lindhart, Sølling, Christoffer, Brøchner, Anne Craveiro, Krag, Mette, Pfortmueller, Carmen, Kriz, Miroslav, Siegemund, Martin, Albano, Giovanni, Aagaard, Søren Rosborg, Bundgaard, Helle, Crone, Vera, Wichmann, Sine, Johnstad, Bror, Martin, Yvonne Karin, Seidel, Philipp, Mårtensson, Johan, Hollenberg, Jacob, Wistrand, Mats, Donati, Abele, Barbara, Enrico, Karvunidis, Thomas, Hollinger, Alexa, Carsetti, Andrea, Lumlertgul, Nuttha, Joelsson-Alm, Eva, Lambiris, Nikolas, Aslam, Tayyba Naz, Friberg, Fredrik Femtehjell, Vesterlund, Gitte Kingo, Mortensen, Camilla Bekker, Vestergaard, Stine Rom, Caspersen, Sidsel Fjordbak, Jensen, Diana Bertelsen, Borup, Morten, Rasmussen, Bodil Steen, and Perner, Anders

Published
2023
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17. Genomic basis for skin phenotype and cold adaptation in the extinct Steller’s sea cow

Author

Le Duc, Diana, Velluva, Akhil, Cassatt-Johnstone, Molly, Olsen, Remi-Andre, Baleka, Sina, Lin, Chen-Ching, Lemke, Johannes R, Southon, John R, Burdin, Alexander, Wang, Ming-Shan, Grunewald, Sonja, Rosendahl, Wilfried, Joger, Ulrich, Rutschmann, Sereina, Hildebrandt, Thomas B, Fritsch, Guido, Estes, James A, Kelso, Janet, Dalén, Love, Hofreiter, Michael, Shapiro, Beth, and Schöneberg, Torsten

Subjects
Genetics, Animals, Cattle, Dugong, Female, Mammals, Mice, Phenotype
Abstract

Steller's sea cow, an extinct sirenian and one of the largest Quaternary mammals, was described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we complement Steller's descriptions with paleogenomic data from 12 individuals. We identified convergent evolution between Steller's sea cow and cetaceans but not extant sirenians, suggesting a role of several genes in adaptation to cold aquatic (or marine) environments. Among these are inactivations of lipoxygenase genes, which in humans and mouse models cause ichthyosis, a skin disease characterized by a thick, hyperkeratotic epidermis that recapitulates Steller's sea cows' reportedly bark-like skin. We also found that Steller's sea cows' abundance was continuously declining for tens of thousands of years before their description, implying that environmental changes also contributed to their extinction.

Published
2022

18. Declarative Choreographies with Time and Data

Author

Hildebrandt, Thomas T., López, Hugo A., Slaats, Tijs, van der Aalst, Wil, Series Editor, Ram, Sudha, Series Editor, Rosemann, Michael, Series Editor, Szyperski, Clemens, Series Editor, Guizzardi, Giancarlo, Series Editor, Di Francescomarino, Chiara, editor, Burattin, Andrea, editor, Janiesch, Christian, editor, and Sadiq, Shazia, editor

Published
2023
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19. Developing an AI-Enabled IIoT Platform - Lessons Learned from Early Use Case Validation

Author

Eichelberger, Holger, Palmer, Gregory, Reimer, Svenja, Trong Vu, Tat, Do, Hieu, Laridi, Sofiane, Weber, Alexander, Niederée, Claudia, Hildebrandt, Thomas, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Batista, Thais, editor, Bureš, Tomáš, editor, Raibulet, Claudia, editor, and Muccini, Henry, editor

Published
2023
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20. Transforming Dynamic Condition Response Graphs to Safe Petri Nets

Author

Cosma, Vlad Paul, Hildebrandt, Thomas T., Slaats, Tijs, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Gomes, Luis, editor, and Lorenz, Robert, editor

Published
2023
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22. Open science practices for eating disorders research

Author

Burke, Natasha L, Frank, Guido KW, Hilbert, Anja, Hildebrandt, Thomas, Klump, Kelly L, Thomas, Jennifer J, Wade, Tracey D, Walsh, B Timothy, Wang, Shirley B, and Weissman, Ruth Striegel

Subjects
Mental Health, Feeding and Eating Disorders, Humans, clinical trial preregistration, data sharing, eating disorder, material sharing, open access, open science, registered report, replication, reproducibility, transparency, Medical and Health Sciences, Psychology and Cognitive Sciences, Clinical Psychology
Abstract

This editorial seeks to encourage the increased application of three open science practices in eating disorders research: Preregistration, Registered Reports, and the sharing of materials, data, and code. For each of these practices, we introduce updated International Journal of Eating Disorders author and reviewer guidance. Updates include the introduction of open science badges; specific instructions about how to improve transparency; and the introduction of Registered Reports of systematic or meta-analytical reviews. The editorial also seeks to encourage the study of open science practices. Open science practices pose considerable time and other resource burdens. Therefore, research is needed to help determine the value of these added burdens and to identify efficient strategies for implementing open science practices.

Published
2021

23. The ethical assessment of Assisted Reproductive Technologies (ART) in wildlife conservation

Author

de Mori, Barbara, Mercugliano, Elena, Biasetti, Pierfrancesco, Pollastri, Ilaria, Spiriti, Maria Michela, Florio, Daniela, Andreucci, Francesco, Göritz, Frank, Holtze, Susanne, Galli, Cesare, Stejskal, Jan, Colleoni, Silvia, Lazzari, Giovanna, Seet, Steven, Zwilling, Jan, Ndeereh, David, Lekolool, Isaac, Ngulu, Stephen, Mijele, Dominic, Čižmár, Daniel, Simone, Raffaella, Schrade, Lisa, Basile, Simone, and Hildebrandt, Thomas B.

Published
2024
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26. DisCoveR: Accurate & Efficient Discovery of Declarative Process Models

Author

Back, Christoffer Olling, Slaats, Tijs, Hildebrandt, Thomas Troels, and Marquard, Morten

Subjects
Computer Science - Machine Learning, Computer Science - Formal Languages and Automata Theory, Computer Science - Software Engineering, Statistics - Machine Learning
Abstract

Declarative process modeling formalisms - which capture high-level process constraints - have seen growing interest, especially for modeling flexible processes. This paper presents DisCoveR, an extremely efficient and accurate declarative miner for learning Dynamic Condition Response (DCR) Graphs from event logs. We precisely formalize the algorithm, describe a highly efficient bit vector implementation and rigorously evaluate performance against two other declarative miners, representing the state-of-the-art in Declare and DCR Graphs mining. DisCoveR outperforms each of these w.r.t. a binary classification task, achieving an average accuracy of 96.2% in the Process Discovery Contest 2019. Due to its linear time complexity, DisCoveR also achieves run-times 1-2 orders of magnitude below its declarative counterparts. Finally, we show how the miner has been integrated in a state-of-the-art declarative process modeling framework as a model recommendation tool, discuss how discovery can play an integral part of the modeling task and report on how the integration has improved the modeling experience of end-users., Comment: Author's original version

Published
2020

33. Correction: Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)

Author

Anthon, Carl Thomas, Pène, Frédéric, Perner, Anders, Azoulay, Elie, Puxty, Kathryn, Van De Louw, Andry, Barratt-Due, Andreas, Chawla, Sanjay, Castro, Pedro, Póvoa, Pedro, Coelho, Luis, Metaxa, Victoria, Kochanek, Matthias, Liebregts, Tobias, Kander, Thomas, Hästbacka, Johanna, Andreasen, Jo Bønding, Péju, Edwige, Nielsen, Lene Bjerregaard, Hvas, Christine Lodberg, Dufranc, Etienne, Canet, Emmanuel, Lundqvist, Linda, Wright, Christopher John, Schmidt, Julien, Uhel, Fabrice, Ait-Oufella, Hafid, Krag, Mette, Cos Badia, Elisabet, Díaz-Lagares, Cándido, Menat, Sophie, Voiriot, Guillaume, Clausen, Niels Erikstrup, Lorentzen, Kristian, Kvåle, Reidar, Hildebrandt, Thomas, Holten, Aleksander Rygh, Strand, Kristian, Tzalavras, Asterios, Bestle, Morten Heiberg, Klepstad, Pål, Fernandez, Sara, Vimpere, Damien, Paulino, Carolina, Graça, Carina, Lueck, Catherina, Juhl, Christian Svendsen, Costa, Carolina, Bådstøløkken, Per Martin, Miranda, Teresa, Lêdo, Lia Susana Aires, Sousa Torres, Joao Carlos, Granholm, Anders, Møller, Morten Hylander, and Russell, Lene

Published
2023
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35. Contributors

Author

Adamovicz, Laura A., primary, Ahlstrom, Christina A., additional, Allender, Matthew C., additional, Anderson, Neil E., additional, Arnemo, Jon M., additional, Atwood, Todd C., additional, Backues, Kay A., additional, Baitchman, Eric, additional, Ballard, Jennifer R., additional, Barbon, Alberto Rodriguez, additional, Binkley, Laura E., additional, Blyde, David, additional, Brenner, Deena, additional, Brock, A. Paige, additional, Buss, Peter E., additional, Calderón-Hernández, Alejandra, additional, Carpenter, James W., additional, Catenacci, Lilian Silva, additional, Causton, Charlotte, additional, Chai, Norin, additional, Charpentier, Thomas, additional, Chinnadurai, Sathya K., additional, Clancy, Meredith M., additional, Clauss, Marcus, additional, Clifford, Deana L., additional, Conde, Dalia A., additional, Cranfield, Michael, additional, Cushing, Andrew, additional, Dadone, Liza, additional, David, Hugo, additional, Deem, Sharon L., additional, Desbiez, Arnaud L.J., additional, Dislich, Mathias, additional, Dowling, Katherine, additional, Drew, Mark L., additional, Lawrenz, Arne, additional, Duncan, Mary, additional, Edes, Ashley N., additional, Epstein, Jonathan H., additional, Reiss, Andrea Evlyn, additional, Ferrell, Shannon T., additional, Fessl, Birgit, additional, Fidgett, Andrea L., additional, Fox, Kami Z., additional, Foxworth, Steve, additional, Gamble, Kathryn C., additional, Gebreyes, Wondwossen A., additional, Georges, Jean-Yves, additional, Goe, Alexandra, additional, Goeritz, Frank, additional, González-Barrientos, Rocío, additional, de Graaff, Nicolas, additional, Greenwood, Alex D., additional, Greenwood, Andrew, additional, Grimaldi, Wray, additional, Hadfield, Catherine, additional, Hampton, Jordan O., additional, Hanley, Christopher S., additional, Harms, Craig A., additional, Harrison, Tara M., additional, Hernández-Mora, Gabriela, additional, Hermes, Robert, additional, Heatley, J. Jill, additional, Hernández, Benjamín E. Alcántar, additional, Hildebrandt, Thomas Bernd, additional, Hilsenroth, Robert, additional, Hilton, Clayton D., additional, Hoang, Thuy Thi Thu, additional, Holliday, Dawn K., additional, Hyndman, Timothy H., additional, Jakob-Hoff, Richard, additional, Janssen, Donald L., additional, Jennings, Jonathan, additional, Jensen, Trine Hammer, additional, Johnson, Gary, additional, Kalogeropoulu, Szilvia Kalliopi, additional, Kasielke, Susie, additional, Kemp, Lucy, additional, Kertesz, Peter, additional, Kinney, Matthew E., additional, Kluyber, Danilo, additional, Koeppel, Katja N., additional, Krol, Lana, additional, Kuiken, Thijs, additional, Lamberski, Nadine, additional, Langan, Jennifer N., additional, Latimer, Erin E., additional, Leach, Kathryn S., additional, Leclerc, Antoine, additional, Ling, Paul, additional, Lung, Nancy P., additional, Lécu, Alexis, additional, Marinkovich, Matt, additional, Marschang, Rachel E., additional, Masters, Nic, additional, Masuda, Bryce, additional, Mathur, Vibhu Prakash, additional, McLellan, William A., additional, McLelland, David J., additional, Meegan, Jennifer M., additional, Mendoza, Ana Patricia, additional, Meyerson, Randi, additional, Miller, Michael W., additional, Miller, Michele A., additional, Milnes, Ellie L., additional, Moore, Michael J., additional, Moriarty, Megan E., additional, Murphy, Lisa, additional, Murray, Michael J., additional, Mutlow, Adrian, additional, Myers, Debbie, additional, Myers, Gwen, additional, Nevitt, Benjamin, additional, Di Nucci, Dante L., additional, Orozco, María Marcela, additional, Padilla, Luis R., additional, Painer-Gigler, Johanna, additional, Pas, An, additional, Pelton, Craig A., additional, Pereira, Nuno M., additional, Petit, Thierry, additional, Pinter, Adriano, additional, Plangsangmas, Tithipong, additional, Prittie, Jennifer, additional, Quintard, Benoit, additional, Raath, Jacobus P., additional, Ramer, Jan, additional, Ramey, Andrew M., additional, Raphael, Bonnie L., additional, Ratanakorn, Parntep, additional, Rivera, Sam, additional, Rodriguez, Carlos, additional, Rooney, Tess, additional, Rousselet, Estelle, additional, S, Ilayaraja., additional, Sailler, Anaïs, additional, Sanderson, Stephanie, additional, Schiffmann, Christian, additional, Seeber, Peter A., additional, Semjonov, Aleksandr, additional, Sha, Arun A., additional, Sharp, Sarah, additional, Shaw, Michelle E., additional, Sheldon, Julie D., additional, Shopland, Sara, additional, Sleeman, Jonathan M., additional, Smith, Cynthia R., additional, Smith, Joseph A., additional, Soares-Neto, Lauro L., additional, Sripiboon, Supaphen, additional, Stratton, Karin, additional, Swanson, William F., additional, Sós-Koroknai, Viktória, additional, Sós, Endre, additional, Taylor-Cousar, Jennifer L., additional, Teare, J. Andrew, additional, Terio, Karen A., additional, Terrell, Scott P., additional, Thompson, Steve B., additional, Thongthip, Nikorn, additional, Torres, Rodrigo S. Garcés, additional, Tubbs, Christopher W., additional, Vicino, Greg A., additional, Vilchez-Delgado, Fernando Javier, additional, Wack, Raymund F., additional, Wahltinez, Sarah, additional, Walsh, Michael T., additional, Walzer, Chris, additional, Wenker, Christian John, additional, Wiedner, Ellen, additional, Wolfe, Barbara A., additional, Wolfe, Lisa L., additional, Wolfe, Tammy Culpepper, additional, Wyatt, Jeff, additional, Xie, Shangzhe, additional, Yanong, Roy, additional, and Yarto-Jaramillo, Enrique, additional

Published
2023
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39. Pregnancy length and health in giant pandas: What can metabolic and urinary endocrine markers unveil?

Author

Wauters, Jella, Wilson, Kirsten S., Cools, Tom, Vancsok, Catherine, Bouts, Tim, Mulot, Baptiste, Leclerc, Antoine, Haapakoski, Marko, Kok, José, Kühne, Ragnar, Ochs, Andreas, Duncan, W. Colin, Girling, Simon J., Hildebrandt, Thomas B., Zhou, Qiang, Li, Rengui, Zhou, Yingmin, Cai, Kailai, Liu, Yuliang, Hou, Rong, Rae, Mick, Valentine, Iain, Vanhaecke, Lynn, and Li, Desheng

Published
2023
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43. Adapting family-based treatment for paediatric obesity: A randomized controlled pilot trial.

Author

Loeb, Katharine L, Le Grange, Daniel, Celio Doyle, Angela, Crosby, Ross D, Glunz, Catherine, Laraque-Arena, Danielle, Hildebrandt, Thomas, Bacow, Terri, Vangeepuram, Nita, and Gault, Allison

Subjects
Humans, Treatment Outcome, Pilot Projects, Family Therapy, Adolescent, Female, Male, Pediatric Obesity, adolescence, family-based treatment, overweight, paediatric obesity, Nutrition, Pediatric, Clinical Trials and Supportive Activities, Obesity, Prevention, Clinical Research, 7.1 Individual care needs, Management of diseases and conditions, Oral and gastrointestinal, Stroke, Cancer, Cardiovascular, Metabolic and endocrine, Clinical Sciences, Psychology, Clinical Psychology
Abstract

ObjectiveThis pilot study aimed to refine and test an adaption of family-based treatment (FBT) for eating disorders that addressed the distinct clinical needs of adolescents with overweight or obesity in the absence of eating disorder pathology. Our hypothesis was that FBT for paediatric obesity (FBT-PO) would be feasible to implement and superior to a nutrition education counselling (NEC) condition delivered to both parents and patients, thereby controlling for key information dissemination across groups while manipulating active therapeutic content and strategy.MethodSeventy-seven adolescents were randomized to FBT-PO or NEC across two sites.ResultsResults supported our core prediction, in that weight status among adolescent study participants receiving FBT-PO remained stable while increasing among participants randomized to NEC. Attrition was high in both conditions.ConclusionsFBT-PO, while not seeming to yield a marked decrease in body mass index z-score, may arrest an otherwise-occurring weight-gain trajectory for these adolescents. This efficacy finding is consistent with the overall PO literature supporting parental involvement in the treatment of PO. Future research efforts should address retention in FBT-PO.

Published
2019

46. Atrial Fibrillation (AFIB) in the ICU: Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study*

Author

Wetterslev, Mik, Hylander Møller, Morten, Granholm, Anders, Hassager, Christian, Haase, Nicolai, Lange, Theis, Myatra, Sheila N., Hästbacka, Johanna, Arabi, Yaseen M., Shen, Jiawei, Cronhjort, Maria, Lindqvist, Elin, Aneman, Anders, Young, Paul J., Szczeklik, Wojciech, Siegemund, Martin, Koster, Thijs, Aslam, Tayyba Naz, Bestle, Morten H., Girkov, Mia S., Kalvit, Kushal, Mohanty, Rakesh, Mascarenhas, Joanne, Pattnaik, Manoranjan, Vergis, Sara, Haranath, Sai Praveen, Shah, Mehul, Joshi, Ziyokov, Wilkman, Erika, Reinikainen, Matti, Lehto, Pasi, Jalkanen, Ville, Pulkkinen, Anni, An, Youzhong, Wang, Guoxing, Huang, Lei, Huang, Bin, Liu, Wei, Gao, Hengbo, Dou, Lin, Li, Shuangling, Yang, Wanchun, Tegnell, Emily, Knight, Agnes, Czuczwar, Miroslaw, Czarnik, Tomasz, Perner, Anders, Al Humedi, Haifaa Ibrahim, Zellweger, Nuria, Nuciforo, Chiara, Deng, Yanjun, Luo, Hua, Yan, Miao, Engstrøm, Janus, Krag, Mette, Bestle, Frederik H, Poulsen, Lone M, Hildebrandt, Thomas, Sofie Andreasen, Anne, Tjelle Kristiansen, Klaus, Mohr, Thomas, Møller-Sørensen, Hasse, Møller, Kirsten, Gorade, Manoj, Gandhi, Bhavesh, Jha, Tanya, Tisekar, Owais, Kar, Aparjeet, Nimavat, Balkrishan, Lappi, Elina, Heinonen, Jonna, Pettilä, Leena, Iso-Ketola, Maria, Saario, Minttu, Suhonen, Tarja, Vaskelainen, Eija, Halonen, Elina, Rahikainen, Sari, Julkunen, Sonja, Salkio, Sinikka, Mäkinen, Sanna, Ristimäki, Sanna, Hartikainen, Juho, Inkinen, Nina, Tolmunen, Sinikka, Oras, Jonatan, Delaney, Kirsha, Navarra, Leanlove, Cruz, Raulle, Olatunji, Shaanti, Bombinska, Marta, Laake, Jon, Keus, Frederik, and Eck, Ruben

Published
2023
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49. Elephant Gestation: Insights Into Idiopathic Abortions and Stillbirth.

Author

Huijsmans, Tim E. R. G., Van Soom, Ann, Smits, Katrien, Wauters, Jella, Hagan, David, and Hildebrandt, Thomas B.

Abstract

The declining African and Asian elephant populations emphasize the importance of a backup population. Successful reproduction in captivity plays a key role in maintaining such a genetically diverse ex situ population but is challenged by reproductive loss in the form of abortions and stillbirths. The elephants' biphasic prolactin pattern led us to predict a higher incidence of abortions during the time of reduced prolactin concentrations. Therefore, this study focuses on the identification of months during elephant gestation which are prone to loss of pregnancy. A metric was developed to identify the fetal age of aborted calves based on the fetal mass using a regression model. Data on idiopathic abortions in captive and wild elephants collected from zoos, tourist camps, semi‐captive, and free‐ranging populations since 1974 were analyzed, revealing a significantly higher prevalence of abortions during the 15th and 17th month of gestation. Additionally, the prevalence of stillbirths in the 22nd month of gestation between 2000 and 2023 was assessed. Although stillbirths showed a declining trend over time, the average prevalence between 2019 and 2023 was still 2.8%. Consequently, the 15th, 17th, and 22nd month of gestation were identified as stages prone to pregnancy loss. These findings underscore the necessity of researching risk factors and preventative measures for pregnancy loss in these 3 months, especially exploring a possible link with prolactin during the 15th and 17th month of gestation. The identification of stages prone to fetal loss is a key step towards enhancing elephant reproductive success and welfare. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Advanced assisted reproduction technologies in endangered mammalian species.

Author

Hildebrandt, Thomas Bernd and Holtze, Susanne

Subjects
*SEXUAL cycle, *FERTILIZATION in vitro, *ARTIFICIAL insemination, *EMBRYO transfer, *WILDLIFE conservation, *BIOLOGICAL extinction, *REPRODUCTIVE technology
Abstract

A new synergistic approach of classical conservation strategies combined with advanced assisted reproduction technologies (aART) allows for protection and rescue of endangered keystone species at the brink of extinction, which can help to safeguard complex ecosystems. Reproduction biology and management in mammal species is not only challenging in regards to their diverging sizes, anatomy, and often unknown physiology; it also requires customized training or chemical restraint protocols for safe handling. Besides these general challenges, there are several new assisted reproduction techniques (ART) specifically tailored to critically endangered mammals. The current portfolio of ART in these mammalian taxa is ranging from sexual cycle characterization and manipulation, semen collection and cryopreservation, artificial insemination, biobanking of living cells, oocyte collection, in vitro fertilization (IVF), and embryo production, embryo transfer as well as stem cell‐derived in vitro gametogenesis for generating gametes in culture. The article covers advanced assisted reproduction technologies (aART), success and challenges, as well as ethical implications. [ABSTRACT FROM AUTHOR]

Published
2024
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