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6 results on '"Hildebrandt, Friederike"'

2. Distinguishing Early Infections from CRS with Routine and Exploratory Serum Proteomics and the HT10 Score Following CD19 CAR-T for Relapsed/Refractory B-NHL

Author

Rejeski, Kai, primary, Blumenberg, Viktoria, additional, Forsberg, Simon KG, additional, Petrera, Agnese, additional, Mueller, Niklas, additional, Hildebrandt, Friederike, additional, Frölich, Lisa, additional, Karschnia, Philipp, additional, Schmidt, Christian, additional, Dreyling, Martin, additional, von Bergwelt, Michael, additional, Subklewe, Marion, additional, and Buecklein, Veit L, additional

Published
2022
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3. Early Real Time Quantification of CD19. CAR T Cells By Flow Cytometry As a Predictive Biomarker for Response in Patients with R/R LBCL

Author

Blumenberg, Viktoria, primary, Busch, Galina, additional, Baumann, Stephan, additional, Jitschin, Regina, additional, Winkelmann, Michael, additional, Hellwig, Konstantin, additional, Rejeski, Kai, additional, Frölich, Lisa, additional, Tast, Benjamin, additional, Schmidt, Christian, additional, Hildebrandt, Friederike, additional, Dekorsy, Franziska, additional, Schmidkonz, Christian, additional, Bäuerle, Tobias, additional, Kunz, Wolfgang G., additional, Mueller, Fabian, additional, Mougiakakos, Dimitrios, additional, von Bergwelt, Michael, additional, Bücklein, Veit, additional, Mackensen, Andreas, additional, Voelkl, Simon, additional, and Subklewe, Marion, additional

Published
2022
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5. High Bacterial Abundances of Dorea and Pediococcus in the Gut Microbiome Linked to Expansion, Immune Checkpoint Expression and Efficacy of CD19-Directed CAR T-Cells in Patients with r/r DLBCL

Author

Blumenberg, Viktoria, primary, Busch, Galina, additional, Baumann, Stephan, additional, Schmidt, Sabine, additional, Schuhmacher, Hanna, additional, Winkelmann, Michael, additional, Hildebrandt, Friederike, additional, Rejeski, Kai, additional, Vettermann, MD, Franziska J, additional, Kunz, Wolfgang G., additional, von Bergwelt, Michael, additional, Buecklein, Veit, additional, Stein-Thöringer, Christoph, additional, and Subklewe, Marion, additional

Published
2021
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6. High Bacterial Abundances of Doreaand Pediococcusin the Gut Microbiome Linked to Expansion, Immune Checkpoint Expression and Efficacy of CD19-Directed CAR T-Cells in Patients with r/r DLBCL

Author

Blumenberg, Viktoria, Busch, Galina, Baumann, Stephan, Schmidt, Sabine, Schuhmacher, Hanna, Winkelmann, Michael, Hildebrandt, Friederike, Rejeski, Kai, Vettermann, Franziska J, Kunz, Wolfgang G., von Bergwelt, Michael, Buecklein, Veit, Stein-Thöringer, Christoph, and Subklewe, Marion

Abstract

Introduction: The crosstalk of the gut microbiome and the human host can influence T-cell immune responses and has emerged as a modulator in cancer immunotherapy (Gopalakrishnan et al., 2018). Individual bacteria isolated from human fecal specimen were also shown to shape systemic and gut mucosal T cell repertoires (Geva-Zatorsky et al., 2017), and several commensal members of the human gut microbiome were recently associated with the kinetics of the reconstitution of peripheral immune cells after allo-HCT (Schluter et al., 2020). However, in patients treated with CAR T-cells a link between gut microbiome configurations and T-cell characteristics has not been described yet. Recently, we and others could associate low CAR T-cell expansion and dysfunction with treatment failure. Here, we hypothesize that certain gut microbes or even intestinal monodomination of facultative pathogens may correlate with CAR T-cell expansion and expression profile of immune checkpoint molecules which might impact treatment outcome.

Published
2021
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