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377 results on '"Higuchi, Toshihiro"'

4. Lower systolic blood pressure levels in early pregnancy are associated with a decreased risk of early-onset superimposed preeclampsia in women with chronic hypertension: a multicenter retrospective study

Author

Ueda, Akihiko, Hasegawa, Masaaki, Matsumura, Noriomi, Sato, Hiroshi, Kosaka, Kenzo, Abiko, Kaoru, Yoshioka, Shinya, Yoshida, Takaaki, Tatsumi, Keiji, Higuchi, Toshihiro, Fujita, Kohei, Sasaki, Shoko, Goto, Masaki, Takai, Hiroshi, Chigusa, Yoshitsugu, Mogami, Haruta, Sagawa, Norimasa, Mandai, Masaki, and Kondoh, Eiji

Published
2022
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14. Vaginal malignant peripheral nerve sheath tumor treated with complete surgical resection and postoperative radiation therapy.

Author

Mizuta, Yuka, Kozono, Yuki, Asai, Mayu, Sekiyama, Kentaro, Yoshioka, Yumiko, and Higuchi, Toshihiro

Subjects
PHYSICAL diagnosis, VULVA, BIOPSY, METASTASIS, NERVOUS system tumors, MAGNETIC resonance imaging, VAGINAL tumors, RECTUM, TREATMENT effectiveness, POSITRON emission tomography, RADIOTHERAPY, COMPUTED tomography, SARCOMA, DISEASE complications
Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) are neoplasms originating from or differentiating into nerve sheaths of peripheral nerves. Vaginal origin is rare, with only six vaginal primary cases reported to date. A 55‐year‐old woman presented to our hospital with a 7 cm vulvar mass. Tumor biopsy results were suspicious of sarcoma, and pelvic magnetic resonance imaging and hysterofiberscopy showed that the tumor originated from the lower vagina. The mass was transvaginally excised, and histological examination confirmed the diagnosis of a vaginal MPNST with negative surgical margins. The patient underwent radiotherapy because the risk of recurrence was high, owing to the large tumor size and high mitotic index. The patient remained recurrence‐free for 1 year after the primary treatment. This is the first case of a high‐risk vaginal MPNST that avoided early disease recurrence with additional radiotherapy after complete tumor resection. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Improvement in regional disparities in prehospital emergency medical care systems using the prehospital care index: how the timing of adrenaline administration by paramedics impacts cerebral functioning prognosis

Author

Ueta, Hiroki, primary, Tanaka, Hideharu, additional, Takyu, Hiroshi, additional, Sagisaka, Ryo, additional, Tanaka, Shota, additional, Higuchi, Toshihiro, additional, Akihama, Hiroyuki, additional, Takahashi, Hiroyuki, additional, Kinoshi, Tomoya, additional, and Sakanashi, Syuji, additional

Published
2023
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19. Trends and future projections of cervical cancer‐related outcomes in Japan: What happens if the HPV vaccine program is not implemented?

Author

Sakakibara, Atsuko, primary, Nakayama, Takeo, additional, Uchida, Hiroyuki, additional, Odagiri, Youichi, additional, Ito, Yuri, additional, Katayama, Toshiro, additional, Ueda, Yutaka, additional, Higuchi, Toshihiro, additional, Terakawa, Koichi, additional, Matsui, Kunihiko, additional, Miyazaki, Kikuko, additional, and Konishi, Ikuo, additional

Published
2022
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22. Trends and future projections of cervical cancer‐related outcomes in Japan: What happens if the HPV vaccine program is not implemented?

Author

Sakakibara, Atsuko, Nakayama, Takeo, Uchida, Hiroyuki, Odagiri, Youichi, Ito, Yuri, Katayama, Toshiro, Ueda, Yutaka, Higuchi, Toshihiro, Terakawa, Koichi, Matsui, Kunihiko, Miyazaki, Kikuko, and Konishi, Ikuo

Subjects
GENITAL warts, HUMAN papillomavirus vaccines, YOUNG adults, HUMAN papillomavirus, CERVICAL intraepithelial neoplasia, CERVICAL cancer
Abstract

Contrary to other developed countries, in Japan, recent years have seen increases in cervical cancer incidence and mortality among young people. However, the human papillomavirus (HPV) vaccine program, a key measure for avoiding cervical cancer, has been virtually suspended. Temporal changes in cervical cancer profiles in this unique situation have not been fully investigated epidemiologically. Our study aimed to determine the current status and future trends of the incidence and mortality of cervical cancer and precancerous lesions in Japan. Mortality rates of cervical cancer during 1975 to 2016 and incidence rates of cervical cancer and cervical intraepithelial neoplasia (CIN) 3 during 1975 to 2013 were examined using vital statistics and population‐based cancer registry data in Japan. Bayesian age‐period‐cohort analyses were performed to analyze temporal changes of the three cervical cancer‐related outcomes. We also calculated projections to 2028 for the three outcomes, assuming that HPV vaccination coverage and screening rates in Japan would be maintained at the current level after the resumption of the national vaccination program. The risk of occurrence of the three outcomes showed similar changes by birth cohort, peaking in the mid‐1890s to 1900s birth cohorts, declining sharply in the 1940s birth cohort, and persistently increasing in the 1950s and later birth cohorts. Projections to 2028 show increases in cervical cancer incidence and mortality in the 30 to 69 age group, with a particular increase in CIN3 incidence in the 25 to 49 age group, if HPV vaccine programs and screening are not effectively implemented. These findings revealed an increasing cervical disease burden among reproductive age females in Japan. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Functional Connectivity Pattern Using Resting-state fMRI as an Assessment Tool for Spatial Neglect during the Recovery Stage of Stroke: A Pilot Study

Author

Ebisu, Toshihiko, primary, Fukunaga, Masaki, additional, Murase, Tomokazu, additional, Matsuura, Toyoshi, additional, Tomura, Naoya, additional, Miyazaki, Yasuhiro, additional, Osaki, Shinpei, additional, Okada, Tsutomu, additional, Higuchi, Toshihiro, additional, and Umeda, Masahiro, additional

Published
2022
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30. Resting-state functional connectivity predicts recovery from visually induced motion sickness

Author

10332727, Miyazaki, Jungo, Yamamoto, Hiroki, Ichimura, Yoshikatsu, Yamashiro, Hiroyuki, Murase, Tomokazu, Yamamoto, Tetsuya, Umeda, Masahiro, Higuchi, Toshihiro, 10332727, Miyazaki, Jungo, Yamamoto, Hiroki, Ichimura, Yoshikatsu, Yamashiro, Hiroyuki, Murase, Tomokazu, Yamamoto, Tetsuya, Umeda, Masahiro, and Higuchi, Toshihiro

Abstract

Movies depicting certain types of motion often provoke uncomfortable symptoms similar to motion sickness, termed visually induced motion sickness (VIMS). VIMS generally evolves slowly during the viewing of a motion stimulus and, when the stimulus is removed, the recovery proceeds over time. Recent human neuroimaging studies have provided new insights into the neural bases of the evolution of VIMS. In contrast, no study has investigated the neural correlates of the recovery from VIMS. Study of the recovery process is critical for the development of a way to promote recovery and could provide further clues for understanding the mechanisms of VIMS. We thus investigated brain activity during the recovery from VIMS with functional connectivity magnetic resonance imaging. We found enhanced recovery-related functional connectivity patterns involving brain areas such as the insular, cingulate and visual cortical regions, which have been suggested to play important roles in the emergence of VIMS. These regions also constituted large interactive networks. Furthermore, the increase in functional connectivity was correlated with the subjective awareness of recovery for the following five pairs of brain regions: insula–superior temporal gyrus, claustrum–left and right inferior parietal lobules, claustrum–superior temporal gyrus and superior frontal gyrus–lentiform nucleus. Considering the previous findings on the functions of these regions and the present results, it is suggested that the increase in FC may reflect brain processes such as enhanced interoceptive awareness to one’s own bodily state, a neuroplastic change in visual-processing circuits and/or the maintenance of visual spatial memory.

Published
2021

46. Left Ventricular Diastolic Function during the Normal Peripartum Period

Author

30583877, Kimura, Yuki, Kato, Takao, Miyata, Hiromi, Sasaki, Issei, Minamino-Muta, Eri, Nagasawa, Yoshinori, Numao, Shigeharu, Nagano, Tadayoshi, Higuchi, Toshihiro, Inoko, Moriaki, 30583877, Kimura, Yuki, Kato, Takao, Miyata, Hiromi, Sasaki, Issei, Minamino-Muta, Eri, Nagasawa, Yoshinori, Numao, Shigeharu, Nagano, Tadayoshi, Higuchi, Toshihiro, and Inoko, Moriaki

Abstract

Background:Because cardiovascular function and hemodynamics markedly change during pregnancy, our aim was to elucidate left ventricular (LV) diastolic function in pregnant women. Methods and Results:We prospectively collected the data of 397 pregnant women treated between 2012 and 2013. We evaluated their LV systolic and diastolic functions via echocardiography during the 3rd trimester (28–30 weeks’ gestation) and within 4 days of delivery. Additionally, we analyzed the cardiac geometry: relative wall thickness and LV mass index (LVMI). Diastolic dysfunction was defined as early diastolic mitral annulus velocity (e’) <7 cm/s and peak early filling velocity (E)/e’ ratio >15. The pregnant women were 33.7±5.0 years old and the prevalence of hypertensive disorders in pregnancy (HDP) was 4.0%. LV systolic function was preserved in all pregnant women. However, diastolic function significantly decreased after delivery (mean e’: 12.6 vs. 11.6 cm/s, P<0.0001; median E/e’ ratio: 6.4 vs. 7.3, P<0.0001). Diastolic function after delivery was associated with the prevalence of HDP (P=0.035) and was correlated with age (R=−0.17, P=0.0009) and LVMI (R=−0.30, P<0.0001). However, these changes in diastolic function remained within the normal range and only 1 woman (1/397, 0.3%) had LV diastolic dysfunction after delivery. Conclusions:LV diastolic function decreased after delivery in pregnant women but was within the normal range.

Published
2019

47. Factors Associated with Increased Levels of Brain Natriuretic Peptide and Cardiac Troponin I during the Peripartum Period

Author

30583877, Kimura, Yuki, Kato, Takao, Miyata, Hiromi, Sasaki, Issei, Minamino-Muta, Eri, Nagasawa, Yoshinori, Numao, Shigeharu, Nagano, Tadayoshi, Higuchi, Toshihiro, Inoko, Moriaki, 30583877, Kimura, Yuki, Kato, Takao, Miyata, Hiromi, Sasaki, Issei, Minamino-Muta, Eri, Nagasawa, Yoshinori, Numao, Shigeharu, Nagano, Tadayoshi, Higuchi, Toshihiro, and Inoko, Moriaki

Abstract

Background: We aimed to investigate the values and the changes of brain natriuretic peptide (BNP) and cardiac troponin in pregnant women. Methods and results: We prospectively collected the data of 405 pregnant women who were treated at Japanese general hospital between 2012 and 2013. We analyzed their laboratory data and echocardiographic findings during the third trimester (28–30 weeks’ gestation) and within 4 days of delivery. In addition, we evaluated the factors associated with elevation of BNP and cardiac troponin I (cTnI) levels. The pregnant women were 33.8 ± 5.0 years old and the prevalence of pregnancy induced hypertension (PIH) and placental abnormality was 4.2% and 2.5%, respectively. BNP levels increased after delivery (13.2 pg/mL vs. 23.5 pg/mL; P <0.001), correlated with increased left ventricular diastolic dimension (P = 0.035), left atrial dimension (P <0.001), and decreased hemoglobin (P <0.001). Moreover, cTnI levels increased to over 0.015 ng/mL after delivery in 4.0% of pregnant women. In multivariate analysis, PIH (OR: 18.71, P = 0.003), placental abnormality (OR: 26.78, P = 0.007), and decreased hemoglobin after delivery (OR: 2.59, P <0.001) were the factors associated with elevated cTnI. Conclusions: BNP levels increased in association with cardiac chamber enlargement and decreased hemoglobin after delivery. Additionally, the factors affecting elevated cTnI levels were related to labor and delivery.

Published
2019

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