986 results on '"Higgs, Douglas"'
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2. Direct correction of haemoglobin E β-thalassaemia using base editors
3. Reactivation of a developmentally silenced embryonic globin gene.
4. Super-enhancers include classical enhancers and facilitators to fully activate gene expression
5. RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation
6. Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder
7. The α-globin super-enhancer acts in an orientation-dependent manner.
8. The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin
9. Testing the super-enhancer concept
10. The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization
11. Enhancers predominantly regulate gene expression during differentiation via transcription initiation
12. The characteristics of CTCF binding sequences contribute to enhancer blocking activity.
13. An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells
14. The relationship between genome structure and function
15. Genetic dissection of the α-globin super-enhancer in vivo
16. A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells
17. A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker
18. Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate
19. Loss-of-Function Variants in SUPT5H as Modifying Factors in Beta-Thalassemia.
20. The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice
21. Molecular Basis and Genetic Modifiers of Thalassemia
22. Phenotypic and molecular characterization of a serum-free miniature erythroid differentiation system suitable for high-throughput screening and single-cell assays
23. The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist
24. 1005 – SWITCHING GENES ON AND OFF DURING HAEMATOPOIESIS
25. Coregulated Human Globin Genes Are Frequently in Spatial Proximity when Active
26. Annotation of Cis-Regulatory Elements by Identification, Subclassification, and Functional Assessment of Multispecies Conserved Sequences
27. DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease
28. Sir David John Weatherall. 9 March 1933—8 December 2018
29. Loop extrusion by cohesin plays a key role in enhancer-activated gene expression during differentiation
30. The characteristics of CTCF binding sequences contribute to enhancer blocking activity
31. An international registry of survivors with Hb Bart's hydrops fetalis syndrome
32. Dynamics of the 4D genome during in vivo lineage specification and differentiation
33. Identification of a Conserved Erythroid Specific Domain of Histone Acetylation across the α-Globin Gene Cluster
34. Publisher Correction: The relationship between genome structure and function
35. Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains
36. Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants
37. A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
38. Testing the super-enhancer concept
39. Cross-species regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes
40. RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation
41. An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference
42. Author Correction: Enhancer–promoter interactions and transcription
43. α-Globin as a molecular target in the treatment of β-thalassemia
44. ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes
45. Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin
46. The chromatin remodelling factor ATRX suppresses R‐loops in transcribed telomeric repeats
47. A Regulatory SNP Causes a Human Genetic Disease by Creating a New Transcriptional Promoter
48. Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression
49. How to Tackle Challenging ChIP-Seq, with Long-Range Cross-Linking, Using ATRX as an Example
50. A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions
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