Search

Your search keyword '"Higgins, J.P.T. (Julian)"' showing total 5 results
Start Over Author "Higgins, J.P.T. (Julian)"
5 results on '"Higgins, J.P.T. (Julian)"'

1. STrengthening the REporting of Genetic Association studies (STREGA) - An extension of the STROBE statement

Author

Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y. (Guang Yong), Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), Birkett, N. (Nick), Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y. (Guang Yong), Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), and Birkett, N. (Nick)

Abstract

Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the STrengthening the Reporting of OBservational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed, but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct or analysis.

Published
2009
Full Text
View/download PDF

2. STrengthening the REporting of genetic association studies (STREGA)-an extension of the strobe statement

Author

Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y., Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), Birkett, N. (Nick), Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y., Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), and Birkett, N. (Nick)

Abstract

Summary Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic assoc

Published
2009
Full Text
View/download PDF

3. STrengthening the REporting of genetic association studies (STREGA)- An extension of the STROBE statement

Author

Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y., Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), Birkett, N. (Nick), Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y., Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), and Birkett, N. (Nick)

Abstract

Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the STrengthening the Reporting of OBservational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.

Published
2009
Full Text
View/download PDF

4. Strengthening the reporting of genetic association studies (STREGA): An extension of the STROBE statement

Author

Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y., Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), Birkett, N. (Nick), Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y., Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), and Birkett, N. (Nick)

Abstract

Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modeling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.

Published
2009
Full Text
View/download PDF

5. Assessment of cumulative evidence on genetic associations: Interim guidelines

Author

Ioannidis, J.P.A. (John), Boffetta, P. (Paolo), Little, J. (Julian), O'Brien, T.R. (Thomas), Uitterlinden, A.G. (André), Vineis, P. (Paolo), Balding, D.J. (David), Chokkalingam, A. (Anand), Dolan, S.M. (Siobhan), Flanders, W.D. (Dana), Higgins, J.P.T. (Julian), McCarthy, M.I. (Mark), McDermott, D.H. (David), Page, G.P. (Grier), Rebbeck, R. (Timothy), Seminara, D. (Daniela), Khoury, M.J. (Muin Joseph), Ioannidis, J.P.A. (John), Boffetta, P. (Paolo), Little, J. (Julian), O'Brien, T.R. (Thomas), Uitterlinden, A.G. (André), Vineis, P. (Paolo), Balding, D.J. (David), Chokkalingam, A. (Anand), Dolan, S.M. (Siobhan), Flanders, W.D. (Dana), Higgins, J.P.T. (Julian), McCarthy, M.I. (Mark), McDermott, D.H. (David), Page, G.P. (Grier), Rebbeck, R. (Timothy), Seminara, D. (Daniela), and Khoury, M.J. (Muin Joseph)

Abstract

Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semi-quantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generates a composite assessment of 'strong', 'moderate' or 'weak' epidemiological credibility. In addition, we discuss how additional input and guidance can be derived from biological data. Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors.

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results