Search

Your search keyword '"Higano, Nara S"' showing total 163 results
Start Over Author "Higano, Nara S"
163 results on '"Higano, Nara S"'

3. Dynamic imaging using Motion-Compensated SmooThness Regularization on Manifolds (MoCo-SToRM)

Author

Zou, Qing, Torres, Luis A., Fain, Sean B., Higano, Nara S., Bates, Alister J., and Jacob, Mathews

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

We introduce an unsupervised motion-compensated reconstruction scheme for high-resolution free-breathing pulmonary MRI. We model the image frames in the time series as the deformed version of the 3D template image volume. We assume the deformation maps to be points on a smooth manifold in high-dimensional space. Specifically, we model the deformation map at each time instant as the output of a CNN-based generator that has the same weight for all time-frames, driven by a low-dimensional latent vector. The time series of latent vectors account for the dynamics in the dataset, including respiratory motion and bulk motion. The template image volume, the parameters of the generator, and the latent vectors are learned directly from the k-t space data in an unsupervised fashion. Our experimental results show improved reconstructions compared to state-of-the-art methods, especially in the context of bulk motion during the scans.

Published
2021
Full Text
View/download PDF

7. Non-Bronchoscopic Assessment of the Airways

Author

Bates, Alister J., Higano, Nara S., Woods, Jason C., Rounds, Sharon I.S., Series Editor, Dixon, Anne, Series Editor, Schnapp, Lynn M., Series Editor, Goldfarb, Samuel, editor, and Piccione, Joseph, editor

Published
2021
Full Text
View/download PDF

10. Patent Ductus Arteriosus and Lung MRI Phenotype in Moderate and Severe Bronchopulmonary Dysplasia-Pulmonary Hypertension

Author

Bjorkman, Kurt R, primary, Miles, Kimberley G, additional, Bellew, Laura E, additional, Schneider, Kristin A, additional, Magness, S Melissa, additional, Higano, Nara S, additional, Ollberding, Nicholas J, additional, Hoyos Cordon, X, additional, Hirsch, Russel M., additional, Hysinger, Erik B, additional, Woods, Jason C., additional, and Critser, Paul J, additional

Published
2024
Full Text
View/download PDF

13. Patent Ductus Arteriosus and Lung Magnetic Resonance Imaging Phenotype in Moderate and Severe Bronchopulmonary Dysplasia–Pulmonary Hypertension.

Author

Bjorkman, Kurt R., Miles, Kimberley G., Bellew, Laura E., Schneider, Kristin A., Magness, S. Melissa, Higano, Nara S., Ollberding, Nicholas J., Hoyos Cordon, X., Hirsch, Russel M., Hysinger, Erik, Woods, Jason C., and Critser, Paul J.

Subjects
MAGNETIC resonance imaging, PATENT ductus arteriosus, LUNGS, PREMATURE infants, PHENOTYPES, BRONCHOPULMONARY dysplasia, TRACHEOTOMY, FETAL MRI
Abstract

Rationale: Hemodynamically significant patent ductus arteriosus (hsPDA) in premature infants has been associated with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). However, these associations remain incompletely understood. Objectives: To assess the associations between hsPDA duration and clinical outcomes, PH, and phenotypic differences on lung magnetic resonance imaging (MRI). Methods: In this retrospective cohort study, we identified all infants with BPD at <32 weeks' gestation who also underwent research lung MRI at <48 weeks' postmenstrual age (PMA) from 2014 to 2022. Clinical echocardiograms were reviewed for hsPDA and categorized as no hsPDA, hsPDA 1–60 days, and hsPDA >60 days. Outcome variables included BPD severity, PH at 36 weeks' PMA, PH after 36 weeks' PMA in the absence of shunt (PH–pulmonary vascular disease [PVD]), tracheostomy or death, and lung phenotype by MRI via modified Ochiai score, indexed total lung volume, and whole-lung hyperdensity. Logistic regression and ANOVA were used. Measurements and Main Results: In total, 133 infants born at 26.2 ± 1.9 weeks, weighing 776 ± 276 g, were reviewed (47 with no hsPDA, 44 with hsPDA 1–60 days, and 42 with hsPDA >60 d). hsPDA duration > 60 days was associated with BPD severity (P < 0.01), PH at 36 weeks' PMA (adjusted odds ratio [aOR], 9.7 [95% confidence interval (CI), 3.3–28.4]), PH–PVD (aOR, 6.5 [95% CI, 2.3–18.3]), and tracheostomy or death (aOR, 3.0 [95% CI, 1.0–8.8]). Duration of hsPDA > 60 days was associated with higher Ochiai score (P = 0.03) and indexed total lung volume (P = 0.01) but not whole-lung hyperdensity (P = 0.91). Conclusions: In infants with moderate or severe BPD, prolonged exposure to hsPDA is associated with BPD severity, PH–PVD, and increased parenchymal lung disease by MRI. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

19. List of Contributors

Author

Abman, Steven H., primary, Ambalavanan, Namasivayam, additional, Ardini-Poleske, Maryanne E., additional, Aschner, Judy L., additional, Baatz, John E., additional, Baker, Christopher D., additional, Baker, Elizabeth K., additional, Bhandari, Vineet, additional, Bush, Douglas, additional, Cheong, Jeanie L.Y., additional, Chiafery, Marianne C., additional, Collaco, Joseph M., additional, D'Angio, Carl T., additional, Davis, Peter G., additional, Deutsch, Gail H., additional, Dolma, Kalsang, additional, Doyle, Lex W., additional, Dylag, Andrew M., additional, Ekhaguere, Osayame A., additional, Garantziotis, Stavros, additional, Hay, William W., additional, Higano, Nara S., additional, Ibrahim, John, additional, Jensen, Erik A., additional, Keszler, Martin, additional, Kirpalani, Haresh, additional, Kua, K. Lim, additional, Lakshminrusimha, Satyan, additional, Lal, Charitharth Vivek, additional, Leary, Sean, additional, Lynch, Susan K., additional, Malleske, Daniel T., additional, Mandell, Erica W., additional, Mariani, Thomas J., additional, Martin, Richard J., additional, McEvoy, Cindy T., additional, McGrath-Morrow, Sharon A., additional, McKinney, Robin, additional, Misra, Ravi S., additional, Nelin, Leif D., additional, Patel, Ekta U., additional, Pryhuber, Gloria S., additional, Richardson, Colby L. Day, additional, Ryan, Rita M., additional, Savani, Rashmin C., additional, Scheible, Kristin, additional, Schmidt, Barbara, additional, Shepherd, Edward G., additional, Strueby, Lannae, additional, Thébaud, Bernard, additional, Vali, Payam, additional, and Woods, Jason C., additional

Published
2020
Full Text
View/download PDF

22. Initial feasibility and challenges of hyperpolarized 129Xe MRI in neonates with bronchopulmonary dysplasia

Author

Stewart, Neil J., primary, Higano, Nara S., additional, Mukthapuram, Shanmukha, additional, Willmering, Matthew M., additional, Loew, Wolfgang, additional, West, Michael, additional, Arnsperger, Anita, additional, Pratt, Ronald, additional, Rao, Madhwesha R., additional, Schulte, Rolf F., additional, Wild, Jim M., additional, and Woods, Jason C., additional

Published
2023
Full Text
View/download PDF

27. Initial feasibility and challenges of hyperpolarized 129Xe MRI in neonates with bronchopulmonary dysplasia.

Author

Stewart, Neil J., Higano, Nara S., Mukthapuram, Shanmukha, Willmering, Matthew M., Loew, Wolfgang, West, Michael, Arnsperger, Anita, Pratt, Ronald, Rao, Madhwesha R., Schulte, Rolf F., Wild, Jim M., and Woods, Jason C.

Subjects
BRONCHOPULMONARY dysplasia, NEWBORN infants, MAGNETIC resonance imaging, DIFFUSION magnetic resonance imaging, INTENSIVE care patients
Abstract

Purpose: The underlying functional and microstructural lung disease in neonates who are born preterm (bronchopulmonary dysplasia, BPD) remains poorly characterized. Moreover, there is a lack of suitable techniques to reliably assess lung function in this population. Here, we report our preliminary experience with hyperpolarized 129Xe MRI in neonates with BPD. Methods: Neonatal intensive care patients with established BPD were recruited (N = 9) and imaged at a corrected gestational age of median:40.7 (range:37.1, 44.4) wk using a 1.5T neonatal scanner. 2D 129Xe ventilation and diffusion‐weighted images and dissolved phase spectroscopy were acquired, alongside 1H 3D radial UTE. 129Xe images were acquired during a series of short apneic breath‐holds (˜3 s). 1H UTE images were acquired during tidal breathing. Ventilation defects were manually identified and qualitatively compared to lung structures on UTE. ADCs were calculated on a voxel‐wise basis. The signal ratio of the 129Xe red blood cell (RBC) and tissue membrane (M) resonances from spectroscopy was determined. Results: Spiral‐based 129Xe ventilation imaging showed good image quality and sufficient sensitivity to detect mild ventilation abnormalities in patients with BPD. 129Xe ADC values were elevated above that expected given healthy data in older children and adults (median:0.046 [range:0.041, 0.064] cm2s−1); the highest value obtained from an extremely pre‐term patient. 129Xe spectroscopy revealed a low RBC/M ratio (0.14 [0.06, 0.21]). Conclusion: We have demonstrated initial feasibility of 129Xe lung MRI in neonates. With further data, the technique may help guide management of infant lung diseases in the neonatal period and beyond. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

35. Cover Image, Volume 57, Number 4, April 2022

Author

Adaikalam, Stephanie A., primary, Higano, Nara S., additional, Hysinger, Erik B., additional, Bates, Alister J., additional, Fleck, Robert J., additional, Schapiro, Andrew H., additional, House, Melissa A., additional, Nathan, Amy T., additional, Ahlfeld, Shawn K., additional, Brady, Jennifer M., additional, Woods, Jason C., additional, and Kingma, Paul S., additional

Published
2022
Full Text
View/download PDF

36. Tracheostomy prediction model in neonatal bronchopulmonary dysplasia via lung and airway MRI

Author

Adaikalam, Stephanie A., primary, Higano, Nara S., additional, Hysinger, Erik B., additional, Bates, Alister J., additional, Fleck, Robert J., additional, Schapiro, Andrew H., additional, House, Melissa A., additional, Nathan, Amy T., additional, Ahlfeld, Shawn K., additional, Brady, Jennifer M., additional, Woods, Jason C., additional, and Kingma, Paul S., additional

Published
2022
Full Text
View/download PDF

42. Alveolar airspace size in healthy and diseased infant lungs measured via hyperpolarized (3)He gas diffusion MRI

Author

Higano, Nara S., Thomen, Robert P., Quirk, James D., Huyck, Heidie L., Hahn, Andrew D., Fain, Sean B., Pryhuber, Gloria S., and Woods, Jason C.

Subjects
Diffusion Magnetic Resonance Imaging, Infant, Newborn, Humans, Infant, respiratory system, Helium, Lung, Magnetic Resonance Imaging, Article
Abstract

BACKGROUND: Alveolar development and lung parenchymal simplification are not well characterized in vivo in neonatal patients with respiratory morbidities, such as bronchopulmonary dysplasia (BPD). Hyperpolarized (HP) gas diffusion MRI is a sensitive, safe, non-ionizing, and non-invasive biomarker for measuring airspace size in vivo but has not yet been implemented in young infants. OBJECTIVE: This work quantified alveolar airspace size via HP gas diffusion MRI in healthy and diseased explanted infant lung specimens, with comparison to histological morphometry. METHODS: Lung specimens from 8 infants were obtained: 7 healthy left upper lobes (0-16 months, post-autopsy) and 1 left lung with filamin-A mutation, closely representing BPD lung disease (11-months, post-transplantation). Specimens were imaged using HP (3)He diffusion MRI to generate apparent diffusion coefficients (ADC) as biomarkers of alveolar airspace size, with comparison to mean linear intercept (L(m)) via quantitative histology. RESULTS: Mean ADC and L(m) were significantly increased throughout the diseased specimen (ADC=0.26±0.06cm(2)/s, L(m)=587±212μm) compared with healthy specimens (ADC=0.14±0.03cm(2)/s, L(m)=133±37μm; P

Published
2020

43. Quantitative Evaluation of Subglottic Stenosis Using Ultrashort Echo Time MRI in a Rabbit Model

Author

Gandhi, Deep B., primary, Rice, Andrew, additional, Gunatilaka, Chamindu C., additional, Higano, Nara S., additional, Fleck, Robert J., additional, de Alarcon, Alessandro, additional, Hart, Catherine K., additional, Kuo, I‐Chun, additional, Amin, Raouf S., additional, Woods, Jason C., additional, Hysinger, Erik B., additional, and Bates, Alister J., additional

Published
2021
Full Text
View/download PDF

49. Cardiac Magnetic Resonance Imaging Evaluation of Neonatal Bronchopulmonary Dysplasia–associated Pulmonary Hypertension

Author

Critser, Paul J., primary, Higano, Nara S., additional, Tkach, Jean A., additional, Olson, Emilia S., additional, Spielberg, David R., additional, Kingma, Paul S., additional, Fleck, Robert J., additional, Lang, Sean M., additional, Moore, Ryan A., additional, Taylor, Michael D., additional, and Woods, Jason C., additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results