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2. Liquid Biopsy Profiling with Multiple Tests in Patients with Metastatic Breast Cancer

Author

Higa, Nikki, primary, Welter, Lisa, additional, Xu, Liya, additional, Kolatkar, Anand, additional, Bramlett, Kelli S., additional, Gjoerup, Ole V., additional, Graf, Ryon, additional, Huang, Richard S.P., additional, Leary, Rebecca J., additional, Lee, Young, additional, Perkins, Jeremy, additional, Riker, Adam, additional, Singh, Angad P., additional, Tafra, Lorraine, additional, Tweed, Carol K., additional, Shriver, Craig D., additional, Hicks, James, additional, and Kuhn, Peter, additional

Published
2024
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3. Impact of Human Immunodeficiency Virus Drug Resistance Mutations Detected in Women Prior to Antiretroviral Therapy With Efavirenz + Tenofovir Disoproxil Fumarate + Lamivudine (or Emtricitabine).

Author

Boyce, Ceejay L, Sils, Tatiana, Milne, Ross S, Wallner, Jackson J, Hardy, Samantha R, Ko, Daisy, Wong-On-Wing, Annie, Mackey, Malia, Higa, Nikki, Beck, Ingrid A, Styrchak, Sheila M, DeMarrais, Patricia, Tierney, Camlin, Fowler, Mary G, Frenkel, Lisa M, and Team, Promoting Maternal and Infant Survival Everywhere (PROMISE) Study

Subjects
REVERSE transcriptase inhibitors, HIV, HEPATITIS B virus, ANTIRETROVIRAL agents, DRUG resistance
Abstract

Background Two large studies suggest that resistance mutations to only nonnucleoside reverse transcriptase inhibitors (NNRTI) did not increase the risk of virologic failure during antiretroviral therapy (ART) with efavirenz/tenofovir disoproxil fumarate/lamivudine (or emtricitabine). We retrospectively evaluated a third cohort to determine the impact of NNRTI resistance on the efficacy of efavirenz-based ART. Methods Postpartum women living with human immunodeficiency virus (HIV) were studied if they initiated efavirenz-based ART because of the World Health Organization's recommendation for universal ART. Resistance was detected by Sanger genotyping plasma prior to efavirenz-based ART and at virologic failure (HIV RNA >400 copies/mL). Logistic regression examined relationships between pre-efavirenz genotypes and virologic failure. Results Pre-efavirenz resistance was detected in 169 of 1223 (13.8%) participants. By month 12 of efavirenz-based ART, 189 of 1233 (15.3%) participants had virologic failure. Rates of virologic failure did not differ by pre-efavirenz NNRTI resistance. However, while pre-efavirenz nucleos(t)ide reverse transcriptase inhibitors (NRTI) and NNRTI resistance was rare (8/1223 [0.7%]) this genotype increased the odds (adjusted odds ratio, 11.2 [95% confidence interval, 2.21–72.2]) of virologic failure during efavirenz-based ART. Age, time interval between last viremic visit and efavirenz initiation, clinical site, viremia at delivery, hepatitis B virus coinfection, and antepartum regimen were also associated with virologic failure. Conclusions Resistance to NNRTI alone was prevalent and dual-class (NRTI and NNRTI) resistance was rare in this cohort, with only the latter associated with virologic failure. This confirms others' findings that, if needed, efavirenz-based ART offers most people an effective alternative to dolutegravir-based ART. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Cell State and Cell Type: Deconvoluting Circulating Tumor Cell Populations in Liquid Biopsies by Multi-Omics

Author

Welter, Lisa, primary, Zheng, Serena, additional, Setayesh, Sonia Maryam, additional, Morikado, Michael, additional, Agrawal, Arushi, additional, Nevarez, Rafael, additional, Naghdloo, Amin, additional, Pore, Milind, additional, Higa, Nikki, additional, Kolatkar, Anand, additional, Thiele, Jana-Aletta, additional, Sharma, Priyanka, additional, Moore, Halle C. F., additional, Richer, Jennifer K., additional, Elias, Anthony, additional, Pienta, Kenneth J., additional, Zurita, Amado J., additional, Gross, Mitchell E., additional, Shishido, Stephanie N., additional, Hicks, James, additional, Velasco, Carmen Ruiz, additional, and Kuhn, Peter, additional

Published
2023
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5. Abstract P5-05-09: Multianalyte liquid biopsy to aid the diagnostic workup of breast cancer

Author

Shishido, Stephanie, primary, Kuhn, Peter, additional, Mason, Jeremy, additional, Hicks, James, additional, Nevarez, Rafael, additional, Matsumoto, Nicholas, additional, Kolatkar, Anand, additional, Velasco, Carmen Ruiz, additional, Anderson, Amanda, additional, Kidd, Michael, additional, Wilkinson, Kathy, additional, Hwang, E Shelley, additional, Lu, Janice, additional, Nieva, Jorge, additional, Higa, Nikki, additional, Naghdloo, Amin, additional, Hart, Olivia, additional, and Setayesh, Sonia Maryam, additional

Published
2023
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6. Contrived Materials and a Data Set for the Evaluation of Liquid Biopsy Tests

Author

Hernandez, Kyle M., primary, Bramlett, Kelli S., additional, Agius, Phaedra, additional, Baden, Jonathan, additional, Cao, Ru, additional, Clement, Omoshile, additional, Corner, Adam S., additional, Craft, Jonathan, additional, Dean, Dennis A., additional, Dry, Jonathan R., additional, Grigaityte, Kristina, additional, Grossman, Robert L., additional, Hicks, James, additional, Higa, Nikki, additional, Holzer, Timothy R., additional, Jensen, Jeffrey, additional, Johann, Donald J., additional, Katz, Sigrid, additional, Kolatkar, Anand, additional, Keynton, Jennifer L., additional, Lee, Jerry S.H., additional, Maar, Dianna, additional, Martini, Jean-Francois, additional, Meyer, Christopher G., additional, Roberts, Peter C., additional, Ryder, Matt, additional, Salvatore, Lea, additional, Schageman, Jeoffrey J., additional, Somiari, Stella, additional, Stetson, Daniel, additional, Stern, Mark, additional, Xu, Liya, additional, and Leiman, Lauren C., additional

Published
2023
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7. Implementation of an interactive mobile application to pilot a rapid assay to detect HIV drug resistance mutations in Kenya

Author

Vrana, Justin D., primary, Panpradist, Nuttada, additional, Higa, Nikki, additional, Ko, Daisy, additional, Ruth, Parker, additional, Kanthula, Ruth, additional, Lai, James J., additional, Yang, Yaoyu, additional, Sakr, Samar R., additional, Chohan, Bhavna, additional, Chung, Michael H., additional, Frenkel, Lisa M., additional, Lutz, Barry R., additional, Klavins, Eric, additional, and Beck, Ingrid A., additional

Published
2022
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8. Implementation of an interactive mobile application to pilot a rapid assay to detect HIV drug resistance mutations in Kenya

Author

Vrana, Justin D., primary, Panpradist, Nuttada, additional, Higa, Nikki, additional, Ko, Daisy, additional, Ruth, Parker, additional, Kanthula, Ruth, additional, Lai, James J., additional, Yang, Yaoyu, additional, Sakr, Samar R., additional, Chohan, Bhavna, additional, Chung, Michael H., additional, Frenkel, Lisa M., additional, Lutz, Barry R., additional, Klavins, Eric, additional, and Beck, Ingrid A., additional

Published
2021
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9. OLA-Simple: A software-guided HIV-1 drug resistance test for low-resource laboratories

Author

Panpradist, Nuttada, primary, Beck, Ingrid A., additional, Vrana, Justin, additional, Higa, Nikki, additional, McIntyre, David, additional, Ruth, Parker S., additional, So, Isaac, additional, Kline, Enos C., additional, Kanthula, Ruth, additional, Wong-On-Wing, Annie, additional, Lim, Jonathan, additional, Ko, Daisy, additional, Milne, Ross, additional, Rossouw, Theresa, additional, Feucht, Ute D., additional, Chung, Michael, additional, Jourdain, Gonzague, additional, Ngo-Giang-Huong, Nicole, additional, Laomanit, Laddawan, additional, Soria, Jaime, additional, Lai, James, additional, Klavins, Eric D., additional, Frenkel, Lisa M., additional, and Lutz, Barry R., additional

Published
2019
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10. Association of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment

Author

Higa, Nikki, primary, Pelz, Amy, primary, Birch, Donald, primary, Beck, Ingrid A, primary, Sils, Tatiana, primary, Samson, Pearl, primary, Bwakura-Dangarembizi, Mutsawashe, primary, Bolton-Moore, Carolyn, primary, Capparelli, Edmund, primary, Chadwick, Ellen, primary, and Frenkel, Lisa M, primary

Published
2019
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11. Association of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment.

Author

Higa, Nikki, Pelz, Amy, Birch, Donald, Beck, Ingrid A, Sils, Tatiana, Samson, Pearl, Bwakura-Dangarembizi, Mutsawashe, Bolton-Moore, Carolyn, Capparelli, Edmund, Chadwick, Ellen, and Frenkel, Lisa M

Subjects
*DRUG therapy for tuberculosis, *DRUG resistance, *HIV infections, *TREATMENT effectiveness, *EFAVIRENZ, *PRENATAL exposure delayed effects, *MIXED infections, *CHILDREN
Abstract

Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non–nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occurred in 2 of these children; they were last tested at 16 and 24 weeks of ART. Pre-ART NNRTI resistance was not associated with virologic failure. [ABSTRACT FROM AUTHOR]

Published
2020
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12. The Other Pain.

Author

Higa, Nikki

Subjects
TRAFFIC accidents, THERAPEUTICS
Abstract

A personal narrative is presented which explores the author's experience of figuring in a car accident and the therapy for his injuries that followed.

Published
2013

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