10 results on '"Hidetoshi Yanagi"'
Search Results
2. Depressive symptoms interfere with the improvement in exercise capacity by cardiac rehabilitation after left ventricular assist device implantation
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Hidetoshi Yanagi, Rei Ono, Kazufumi Kitagaki, Harumi Konishi, Michio Nakanishi, and Yukihiro Shimada
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Biomedical Engineering ,Medicine (miscellaneous) ,Bioengineering ,Physical strength ,Biomaterials ,Oxygen Consumption ,Quality of life ,Internal medicine ,Humans ,Medicine ,Muscle Strength ,Diuretics ,Depression (differential diagnoses) ,Retrospective Studies ,Cardiac Rehabilitation ,Exercise Tolerance ,Rehabilitation ,Depression ,business.industry ,VO2 max ,General Medicine ,Middle Aged ,Exercise capacity ,Confidence interval ,Ventricular assist device ,Quality of Life ,Cardiology ,Female ,Heart-Assist Devices ,business - Abstract
BACKGROUND Although depressive symptoms are associated with an increased risk of readmission after left ventricular assist device (LVAD) implantation, it is unclear whether they affect the efficacy of exercise-based cardiac rehabilitation (EBCR). This study aimed to investigate the effect of depressive symptoms on EBCR efficacy. METHODS We analyzed 48 patients who participated in EBCR after LVAD implantation (mean age 45 ± 12 years; 60% male). Patients were classified into two groups using the Zung Self-Rating Depression Scale (SDS): depressive group (SDS ≥40, n = 27) and non-depressive group (SDS
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- 2021
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3. Effect of Exercise Training in Heart Failure Patients Without Echocardiographic Response to Cardiac Resynchronization Therapy
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Masahiro Kohzuki, Hidetoshi Yanagi, Saori Yamada, Michio Nakanishi, Noriyuki Fukui, Harumi Konishi, Sayako Fujii, and Kazufumi Kitagaki
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medicine.medical_specialty ,Cardiac resynchronization therapy ,Ejection fraction ,Cardiac Rehabilitation ,business.industry ,medicine.medical_treatment ,Original article ,Exercise therapy ,VO2 max ,Heart failure ,General Medicine ,Isometric exercise ,Exercise capacity ,medicine.disease ,Internal medicine ,cardiovascular system ,Cardiology ,Medicine ,business ,Ventricular dyssynchrony ,Adverse effect ,Peak oxygen uptake - Abstract
Background: Cardiac resynchronization therapy (CRT) is an effective treatment of heart failure (HF) with ventricular dyssynchrony, but not all patients respond to a similar extent. We investigated the efficacy and safety of exercise training (ET) in patients without response to CRT. Methods and Results: Thirty-four patients who participated in a 3-month ET program and underwent cardiopulmonary exercise testing at baseline and after the program were divided into 17 responders and 17 non-responders based on echocardiographic response criteria: either an increase in ejection fraction (EF) ≥10% or a reduction in left ventricular (LV) end-systolic volume ≥10%. Baseline characteristics including peak oxygen uptake (V̇O2) and isometric knee extensor muscle strength (IKEMS) were similar in both groups, but non-responders had lower EF and larger LV. During the ET program, neither group had exercise-related adverse event including life-threatening ventricular arrhythmia. Peak V̇O2 and IKEMS were significantly improved in both groups and there was no significant difference in change in peak V̇O2 or IKEMS between responders and non-responders. On multiple regression analysis, change in IKEMS was an independent predictor of change in peak V̇O2, whereas the response to CRT was not. Conclusions: In HF patients undergoing CRT implantation, ET safely improved exercise capacity regardless of response to CRT, suggesting that even advanced HF patients without response to CRT can possibly benefit from ET.
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- 2019
4. GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region
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Yuki Ishikawa, Nao Tanaka, Yoshihide Asano, Masanari Kodera, Yuichiro Shirai, Mitsuteru Akahoshi, Minoru Hasegawa, Takashi Matsushita, Kazuyoshi Saito, Sei-ichiro Motegi, Hajime Yoshifuji, Ayumi Yoshizaki, Tomohiro Kohmoto, Kae Takagi, Akira Oka, Miho Kanda, Yoshihito Tanaka, Yumi Ito, Kazuhisa Nakano, Hiroshi Kasamatsu, Akira Utsunomiya, Akiko Sekiguchi, Hiroaki Niiro, Masatoshi Jinnin, Katsunari Makino, Takamitsu Makino, Hironobu Ihn, Motohisa Yamamoto, Chisako Suzuki, Hiroki Takahashi, Emi Nishida, Akimichi Morita, Toshiyuki Yamamoto, Manabu Fujimoto, Yuya Kondo, Daisuke Goto, Takayuki Sumida, Naho Ayuzawa, Hidetoshi Yanagida, Tetsuya Horita, Tatsuya Atsumi, Hirahito Endo, Yoshihito Shima, Atsushi Kumanogoh, Jun Hirata, Nao Otomo, Hiroyuki Suetsugu, Yoshinao Koike, Kohei Tomizuka, Soichiro Yoshino, Xiaoxi Liu, Shuji Ito, Keiko Hikino, Akari Suzuki, Yukihide Momozawa, Shiro Ikegawa, Yoshiya Tanaka, Osamu Ishikawa, Kazuhiko Takehara, Takeshi Torii, Shinichi Sato, Yukinori Okada, Tsuneyo Mimori, Fumihiko Matsuda, Koichi Matsuda, Tiffany Amariuta, Issei Imoto, Keitaro Matsuo, Masataka Kuwana, Yasushi Kawaguchi, Koichiro Ohmura, and Chikashi Terao
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Science - Abstract
Abstract Here we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead SNP is in the FCGR/FCRL region, which shows a penetrating association in the Asian population, while a complete linkage disequilibrium SNP, rs10917688, is found in a cis-regulatory element for IRF8. IRF8 is also a significant locus in European GWAS for systemic sclerosis, but rs10917688 only shows an association in the presence of the risk allele of IRF8 in the Japanese population. Further analysis shows that rs10917688 is marked with H3K4me1 in primary B cells. A meta-analysis with a European GWAS detects 30 additional significant loci. Polygenic risk scores constructed with the effect sizes of the meta-analysis suggest the potential portability of genetic associations beyond populations. Prioritizing the top 5% of SNPs of IRF8 binding sites in B cells improves the fitting of the polygenic risk scores, underscoring the roles of B cells and IRF8 in the development of systemic sclerosis. The results also suggest that systemic sclerosis shares a common genetic architecture across populations.
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- 2024
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5. Effects of exercise training on physical activity in heart failure patients treated with cardiac resynchronization therapy devices or implantable cardioverter defibrillators
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Kazufumi Kitagaki, Saori Yamada, Harumi Konishi, Hidetoshi Yanagi, Taku Harada, Masahiro Kohzuki, and Michio Nakanishi
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Physical activity ,Cardiac resynchronization therapy ,heart failure ,Physical Therapy, Sports Therapy and Rehabilitation ,RM1-950 ,Cardiac Resynchronization Therapy ,defibrillator ,medicine ,Humans ,Cardiac Resynchronization Therapy Devices ,Prospective Studies ,Prospective cohort study ,Depression (differential diagnoses) ,exercise ,business.industry ,Rehabilitation ,General Medicine ,Middle Aged ,medicine.disease ,Physical activity level ,Defibrillators, Implantable ,Heart failure ,Physical therapy ,Observational study ,Female ,Therapeutics. Pharmacology ,business - Abstract
Objective: This study elucidated the effects of exercise training on physical activity, 6-min walk distance, and all-cause hospitalization rates in patients with chronic heart failure, and evaluated factors contributing to changes in physical activity. Design: Prospective cohort observational study. Patients and methods: Patients (n =62) who completed an exercise training programme after implantable cardioverter-defibrillator or cardiac resynchronization therapy treatment between May 2017 and May 2018 were included. Patients exercised for 20–50 min 3–5 times weekly for 3 months and were assigned to the active (≥ 10 min/day) or non-active (
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- 2020
6. Cardiac rehabilitation program improves exercise capacity in heart transplantation recipients regardless of marginal donor factors
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Rei Ono, Hidetoshi Yanagi, Harumi Konishi, Kazufumi Kitagaki, Yukihiro Shimada, and Michio Nakanishi
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Physical strength ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Medicine ,Humans ,030212 general & internal medicine ,Retrospective Studies ,Heart transplantation ,Rehabilitation ,Cardiac Rehabilitation ,Exercise Tolerance ,business.industry ,VO2 max ,Exercise capacity ,Vascular surgery ,Tissue Donors ,Transplant Recipients ,Cardiac surgery ,Exercise Therapy ,Marginal donor ,Cardiology ,Heart Transplantation ,Female ,Cardiology and Cardiovascular Medicine ,business ,Program Evaluation - Abstract
Cardiac rehabilitation (CR) is recommended to improve exercise capacity after heart transplantation (HTx); however, the effects of marginal donor factors are unclear. Forty-one recipients participated in a 3-month CR program early after HTx (mean age 39 ± 14 years; 88% male). Patients were divided into marginal (≥ 2 marginal donor factors; n = 24) and control groups (
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- 2020
7. Predictors of improvements in exercise capacity during cardiac rehabilitation in the recovery phase after coronary artery bypass graft surgery versus acute myocardial infarction
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Hidetoshi Yanagi, Kazufumi Kitagaki, Kenichi Ito, Yoichi Goto, Kazuya Yamamoto, Harumi Konishi, Michio Nakanishi, Yuji Suzuki, Noriyuki Fukui, and Tetsuo Arakawa
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Male ,medicine.medical_specialty ,Anemia ,Myocardial Infarction ,030204 cardiovascular system & hematology ,Electrocardiography ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,Coronary Artery Bypass ,Aged ,Retrospective Studies ,Univariate analysis ,Cardiac Rehabilitation ,Exercise Tolerance ,business.industry ,VO2 max ,Recovery of Function ,Vascular surgery ,medicine.disease ,Brain natriuretic peptide ,Exercise Therapy ,Surgery ,Cardiac surgery ,surgical procedures, operative ,medicine.anatomical_structure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies ,Artery - Abstract
This study aimed to elucidate the predictors of improvements in exercise capacity during cardiac rehabilitation (CR) in the recovery phase after coronary artery bypass graft surgery (CABG) versus acute myocardial infarction (AMI). We studied 152 patients (91 after AMI and 61 after CABG) who participated in a 3-month CR program. All patients underwent a cardiopulmonary exercise test, blood tests, maximal quadriceps isometric strength (QIS) measurement, and bioelectrical impedance body composition measurement at the beginning and end of the 3-month CR program. At baseline, the percentage of predicted peak oxygen uptake (%pred-PVO2), maximal QIS, and hemoglobin (Hb) were significantly lower, while C-reactive protein (CRP) was significantly higher, in the CABG than the AMI group. After the 3-month CR, %change in PVO2 (%ΔPVO2) was significantly greater in the CABG than the AMI group (18 ± 15% vs 11 ± 12%, P
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- 2017
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8. Cholinesterase levels predict exercise capacity in cardiac recipients early after transplantation
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Hidetoshi Yanagi, Kazuya Yamamoto, Rei Ono, Noriyuki Fukui, Michio Nakanishi, Kazufumi Kitagaki, Harumi Konishi, Masanobu Yanase, Yuji Suzuki, and Norihide Fukushima
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Isometric exercise ,030204 cardiovascular system & hematology ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Natriuretic peptide ,medicine ,Cholinesterases ,Humans ,Muscle, Skeletal ,Cholinesterase ,Heart transplantation ,Heart Failure ,Transplantation ,030109 nutrition & dietetics ,Rehabilitation ,Exercise Tolerance ,biology ,business.industry ,VO2 max ,medicine.disease ,Prognosis ,Heart failure ,Cardiology ,biology.protein ,Heart Transplantation ,Female ,business ,human activities ,Follow-Up Studies - Abstract
PURPOSE Although cardiac rehabilitation is recommended for patients early after heart transplantation (HTx), adequate exercise effect cannot always be obtained, partly because in patients with chronic heart failure, exercise capacity is reduced due to malnutrition while waiting for HTx. This study aimed to investigate the relationships between exercise capacity and clinical variables, including nutritional indicators, early after HTx. PATIENTS AND METHODS Forty-three HTx recipients were studied. The mean age at HTx was 38 ± 14 years, and 86% were male. We assessed the relationships between peak oxygen uptake (VO2 ) and clinical variables, including plasma B-type natriuretic peptide (BNP), isometric knee extensor muscle strength (KEMS), and nutritional indicators within 1 week of their respective discharges. RESULTS Peak VO2 correlated positively with isometric KEMS (r = .63, P
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- 2017
9. SAPHO Syndrome Complicated by Lesions of the Central Nervous System Successfully Treated with Brodalumab
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Masahide Funabiki, Masayuki Tahara, Seiko Kondo, Naho Ayuzawa, and Hidetoshi Yanagida
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Diseases of the musculoskeletal system ,RC925-935 - Abstract
Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare disease with an unknown entity that affects the skin and the peripheral and/or axial joints. Here, we report on a patient with SAPHO syndrome complicated by lesions of the central nervous system who was successfully treated with brodalumab, an IL-17 receptor blocker. He had been suffering from arthralgia in the wrists and knees as well as axial symptoms such as back pain and assimilation of cervical vertebrae. He had been treated with corticosteroid, salazosulfapyridine, methotrexate, and bisphosphonate; however, his peripheral and axial articular manifestation were intractable. Recently, biologics predominantly targeting TNF-α is employed for difficult-to-treat SAPHO cases; however, he had been complicated with the lesions of the central nervous system resembling multiple sclerosis (MS), an inflammatory demyelinating disorder in the central nervous system, for which application of TNF-α inhibitor is contraindicated. Alternatively, brodalumab was administered , which promptly ameliorated the articular manifestations without aggravating the lesions of the central nervous system. We propose that this type of IL-17 blockade could be an alternative therapy for DMARDs-resistant SAPHO syndrome.
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- 2023
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10. EFFECTS OF EXERCISE THERAPY ON POLYMYOSITIS COMPLICATED BY POST-MYOCARDITIS CARDIOMYOPATHY: A CASE REPORT.
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Hidetoshi YANAGI and Naohisa SHINDO
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- 2017
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