Search

Two typical fixed-length random number generation problems in information theory are considered for general sources. One is the source resolvability problem and the other is the intrinsic randomness problem. In each of these problems, the optimum achievable rate with respect to the given approximation measure is one of our main concerns and has been characterized using two different information quantities: the information spectrum and the smooth Rényi entropy. Recently, optimum achievable rates with respect to f-divergences have been characterized using the information spectrum quantity. The f-divergence is a general non-negative measure between two probability distributions on the basis of a convex function f. The class of f-divergences includes several important measures such as the variational distance, the KL divergence, the Hellinger distance and so on. Hence, it is meaningful to consider the random number generation problems with respect to f-divergences. However, optimum achievable rates with respect to f-divergences using the smooth Rényi entropy have not been clarified yet in both problems. In this paper, we try to analyze the optimum achievable rates using the smooth Rényi entropy and to extend the class of f-divergence. To do so, we first derive general formulas of the first-order optimum achievable rates with respect to f-divergences in both problems under the same conditions as imposed by previous studies. Next, we relax the conditions on f-divergence and generalize the obtained general formulas. Then, we particularize our general formulas to several specified functions f. As a result, we reveal that it is easy to derive optimum achievable rates for several important measures from our general formulas. Furthermore, a kind of duality between the resolvability and the intrinsic randomness is revealed in terms of the smooth Rényi entropy. Second-order optimum achievable rates and optimistic achievable rates are also investigated.

1550 nm wavelength photonic-crystal surface-emitting lasers (PCSELs) are attractive for optical communication and eye-safe sensing applications. In this study, we present InP-based PCSELs featuring a double-lattice photonic-crystal structure designed for high-power single-mode operation at a wavelength of 1550 nm. These PCSELs demonstrate output powers exceeding 300 mW under continuous-wave conditions at 25 °C. Additionally, highly stable single-mode oscillation with a side-mode suppression ratio of over 60 dB is verified at temperatures from 15 °C to 60 °C. Measurement and simulation of photonic band structures reveal the impacts of the threshold gain margin and optical coupling coefficient on the single-mode stability.

We introduce the problem of variable-length (VL) source resolvability, in which a given target probability distribution is approximated by encoding a VL uniform random number, and the asymptotically minimum average length rate of the uniform random number, called the VL resolvability, is investigated. We first analyze the VL resolvability with the variational distance as an approximation measure. Next, we investigate the case under the divergence as an approximation measure. When the asymptotically exact approximation is required, it is shown that the resolvability under two kinds of approximation measures coincides. We then extend the analysis to the case of channel resolvability, where the target distribution is the output distribution via a general channel due to a fixed general source as an input. The obtained characterization of channel resolvability is fully general in the sense that, when the channel is just an identity mapping, it reduces to general formulas for source resolvability. We also analyze the second-order VL resolvability.

Objective: The improvements of antitumor effects and tolerability on chemotherapy for advanced hepatocellular carcinoma (HCC) are warranted. Here, we aimed to elucidate the mechanism of the combining effect of tyrosine kinase inhibitor sorafenib (SOR) and iron chelator deferasirox (DFX) in human hepatoma cell lines, HepG2 and Huh-7. Methods: The types of programmed cell deaths (PCDs); necrosis/necroptosis and apoptosis, were evaluated by flow cytometry and fluorescent microscopy. Human cleaved caspase-3 was analyzed by ELISA for apoptosis. GSH assay was used for ferroptosis. PCDs inhibition was analyzed by adding apoptosis inhibitor Z-VAD-FMK, ferroptosis inhibitor ferrostatin-1, necroptosis inhibitor necrosulfonamide, respectively. The expression of NF-κB was quantified by Western blotting. Results: In SOR monotherapy, cleaved caspase-3 expression was increased in all concentrations, confirming the result that SOR induces apoptosis. In SOR monotherapy, GSH/GSSG ratio was decreased on concentration-dependent, showing that SOR also induced ferroptosis. Lipid Peroxidation caused by SOR, corresponding to ferroptosis, was suppressed by DFX. In fluorescence microscopy of SOR monotherapy, apoptosis was observed at a constant rate on all concentrations, while necroptosis and ferroptosis were increased on high concentration. In sorafenib and deferasirox combinations, sub G1 phase increased additively. In SOR and DFX combinations, the cytotoxic effects were not suppressed by ferrostatin-1, but suppressed by Z-VAD-FMK and necrosulfonamide. In each monotherapy, and SOR + DFX combinations, the expression of NF-κB in nucleus was suppressed. Regarding PCD by SOR and DFX combination, ferroptosis was suppressed and both apoptosis and necroptosis became dominant. Conclusion: Suppression of NF-κB is possibly involved in the effect of DFX. As a result, SOR and DFX combination showed additive antitumor effects for HCC through the mechanism of programed cell deaths and NF-kB signal modification.

The utilization of databases such as IoT has progressed, and understanding how to protect the privacy of data is an important issue. As pioneering work, in 1983, Yamamoto assumed the source (database), which consists of public information and private information, and found theoretical limits (first-order rate analysis) among the coding rate, utility and privacy for the decoder in two special cases. In this paper, we consider a more general case based on the work by Shinohara and Yagi in 2022. Introducing a measure of privacy for the encoder, we investigate the following two problems: The first problem is the first-order rate analysis among the coding rate, utility, privacy for the decoder, and privacy for the encoder, in which utility is measured by the expected distortion or the excess-distortion probability. The second task is establishing the strong converse theorem for utility–privacy trade-offs, in which utility is measured by the excess-distortion probability. These results may lead to a more refined analysis such as the second-order rate analysis.

We consider a binary classification problem for a test sequence to determine from which source the sequence is generated. The system classifies the test sequence based on empirically observed (training) sequences obtained from unknown sources P1 and P2. We analyze the asymptotic fundamental limits of statistical classification for sources with multiple subclasses. We investigate the first- and second-order maximum error exponents under the constraint that the type-I error probability for all pairs of distributions decays exponentially fast and the type-II error probability is upper bounded by a small constant. In this paper, we first give a classifier which achieves the asymptotically maximum error exponent in the class of deterministic classifiers for sources with multiple subclasses, and then provide a characterization of the first-order error exponent. We next provide a characterization of the second-order error exponent in the case where only P2 has multiple subclasses but P1 does not. We generalize our results to classification in the case that P1 and P2 are a stationary and memoryless source and a mixed memoryless source with general mixture, respectively.

Study Design Retrospective study. Purpose To examine the relationship between postoperative bowel bladder disorder (BBD) and the efficacy of needle electrodes for the external anal sphincter (EAS) in intraoperative spinal cord monitoring with transcranial muscle action potentials (Tc-MsEP). Overview of Literature Spinal surgery for spina bifida, spinal cord tumor, and spinal tethered cord syndrome has a high rate of postoperative BBD. Monitoring of the EAS with Tc-MsEP is frequently performed during spinal surgery. We initially used plug-surface electrodes for this purpose, but have more recently switched to needle electrodes for the monitoring of the EAS. To date, there has been no comparison between the utility of these electrodes. Methods Waveform derivation, exacerbation of postoperative BBD, and sensitivity and specificity for prediction of BBD by 70% amplitude reduction of EAS activity using needle and plug-surface electrodes were investigated in 239 spine surgeries. The cut-off for the % drop in amplitude for BBD prediction was determined for EAS monitoring using a needle electrode. Results The overall rate of postoperative BBD aggravation was 7.1% (17/239 cases), with the individual rates using needle and plug-surface electrodes being 6.9% (8/116) and 7.3% (9/123), respectively. The waveform derivation rate was significantly higher using needle electrodes (91.3% [106/116] vs. 76.4% [94/123], p

In the present paper, we investigate the fundamental trade-off of identification, secret-key, storage, and privacy-leakage rates in biometric identification systems for remote or hidden Gaussian sources. We use a technique of converting the system to one where the data flow is in one-way direction to derive the capacity region of these rates. Also, we provide numerical calculations of three different examples for the system. The numerical results imply that it seems hard to achieve both high secret-key and small privacy-leakage rates simultaneously.

There are few long-term reports of patients with frequent PVCs in the absence of ischemic heart disease. In 86 patients without ischemic heart disease, who had 1000 or more PVCs in 24-hour Holter ECG, the number of PVCs during 24-hours Holter ECG and echocardiographic parameters were followed at least 1 year (66.5 ± 39.7 months). PVC was significantly reduced in the patients with or without underlying diseases (UD). The reduction rate in the number of PVCs was prominent in patients with UD. PVC was significantly reduced in patients under medication, but not in patients without medication. In the comparison between the initial and follow up observation using Wilcoxon's rank test, the number of PVC was significantly reduced (P < 0.05), and EF was also improved (P < 0.05) in angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) group, and in β-blocker group. In Ca-antagonist group and antiarrhythmic drug group, the number of PVCs was also significantly reduced (P < 0.05). Multivariate analysis revealed significantly higher incidence (60% or more with PVC reduction) in ACEI/ARB group. These results suggest that the administration of ACEI/ARB may contribute to the reduction of PVC in non-ischemic heart disease cases with multiple PVC.

In forming of glasses frame, bending and inverse bending of rim wires with 4 rolls are usually employed. Only an inverse bending roll, the 4th roll, can change the position to control the curvature of the rim wire. A deriving method of inverse bending roll position is proposed in this study. The proposed method requires not the computational simulations but only some simple steady inverse bending experiments to obtain a relationship between inverse bending roll position and bent curvature which depends on machine condition and bent wire. The experimentally obtained relationship is used in the formulation of deriving the inverse bending roll position. To validate the proposed method, a real glasses frame shape is formed by the proposed and conventional methods. The difference between the designed and formed shapes is evaluated by a sum of absolute shape deviation. The value by the proposed method is smaller up to about 75% than that by the conventional method.

No clinically applicable drug is currently available to enhance neurite elongation after nerve injury. To identify a clinically applicable drug, we screened pre-approved drugs for neurite elongation in the motor neuron-like NSC34 cells. We found that zonisamide, an anti-epileptic and anti-Parkinson's disease drug, promoted neurite elongation in cultured primary motor neurons and NSC34 cells in a concentration-dependent manner. The neurite-scratch assay revealed that zonisamide enhanced neurite regeneration. Zonisamide was also protective against oxidative stress-induced cell death of primary motor neurons. Zonisamide induced mRNA expression of nerve growth factors (BDNF, NGF, and neurotrophin-4/5), and their receptors (tropomyosin receptor kinase A and B). In a mouse model of sciatic nerve autograft, intragastric administration of zonisamide for 1 week increased the size of axons distal to the transected site 3.9-fold. Zonisamide also improved the sciatic function index, a marker for motor function of hindlimbs after sciatic nerve autograft, from 6 weeks after surgery. At 8 weeks after surgery, zonisamide was protective against denervation-induced muscle degeneration in tibialis anterior, and increased gene expression of Chrne, Colq, and Rapsn, which are specifically expressed at the neuromuscular junction. We propose that zonisamide is a potential therapeutic agent for peripheral nerve injuries as well as for neuropathies due to other etiologies.

A deriving method of bending roll position in forming of glasses frame is proposed. The proposed method requires not the computational simulations but only some simple bending tests. To obtain a relationship between bending roll position and bent curvature which depends on material and cross-sectional shape of bent wire, simplified bending experiments in steady bending condition for getting constant curvature are carried out. The experimentally obtained relationship is used in the formulation of deriving the bending roll position for forming glasses frame having curvature distribution. To validate the proposed method, three different shapes are formed by the proposed and conventional methods. The difference between the designed and formed shapes is evaluated by a sum of absolute of shape deviation, and the value by the proposed method is smaller up to about 50 % than that by the conventional method.

BACKGROUND: CD44 is a major cellular receptor for hyaluronic acids. The stem structure of CD44 encoded by ten normal exons can be enlarged by ten variant exons (v1-v10) by alternative splicing. We have succeeded in preparing MV5 fully human IgM and its class-switched GV5 IgG monoclonal antibody (mAb) recognizing the extracellular domain of a CD44R1 isoform that contains the inserted region coded by variant (v8, v9 and v10) exons and is expressed on the surface of various human epithelial cancer cells. METHODS AND PRINCIPAL FINDINGS: We demonstrated the growth inhibition of human cancer xenografts by a GV5 IgG mAb reshaped from an MV5 IgM. The epitope recognized by MV5 and GV5 was identified to a v8-coding region by the analysis of mAb binding to various recombinant CD44 proteins by enzyme-linked immunosorbent assay. GV5 showed preferential reactivity against various malignant human cells versus normal human cells assessed by flow cytometry and immunohistological analysis. When ME180 human uterine cervix carcinoma cells were subcutaneously inoculated to athymic mice with GV5, significant inhibition of tumor formation was observed. Furthermore, intraperitoneal injections of GV5markedly inhibited the growth of visible established tumors from HSC-3 human larynx carcinoma cells that had been subcutaneously transplanted one week before the first treatment with GV5. From in vitro experiments, antibody-dependent cellular cytotoxicity and internalization of CD44R1 seemed to be possible mechanisms for in vivo anti-tumor activity by GV5. CONCLUSIONS: CD44R1 is an excellent molecular target for mAb therapy of cancer, possibly superior to molecules targeted by existing therapeutic mAb, such as Trastuzumab and Cetuximab recognizing human epidermal growth factor receptor family.