1. Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study
- Author
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Shuhei Fukunaga, Ryuichi Nouno, Akihiro Ouchi, Takuji Torimura, Hirohiko Abe, Takumi Kawaguchi, Koutaro Kawaguchi, Tsutomu Nagata, Hidemichi Kawata, Jacob George, Mohammed Eslam, Keiichi Mitsuyama, Hidefumi Kuroki, and Dan Nakano
- Subjects
Male ,Colonoscopy ,thinness ,Disease ,Logistic regression ,Gastroenterology ,0302 clinical medicine ,Risk Factors ,Prevalence ,Biology (General) ,Spectroscopy ,Aged, 80 and over ,medicine.diagnostic_test ,Fatty liver ,General Medicine ,Middle Aged ,Computer Science Applications ,Chemistry ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Female ,Adenoma ,Adult ,medicine.medical_specialty ,QH301-705.5 ,Colorectal adenoma ,Catalysis ,Article ,metabolic syndrome ,Inorganic Chemistry ,liver steatosis ,03 medical and health sciences ,Internal medicine ,Biopsy ,medicine ,Humans ,Physical and Theoretical Chemistry ,QD1-999 ,Molecular Biology ,Aged ,Retrospective Studies ,business.industry ,Organic Chemistry ,non-alcoholic fatty liver disease ,Retrospective cohort study ,colorectal neoplasms ,medicine.disease ,digestive system diseases ,Metabolic syndrome ,business - Abstract
Colorectal adenoma is linked to metabolic dysfunction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has a precise definition and three subtypes, including non-obese MAFLD. We aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to non-alcoholic fatty liver disease (NAFLD) in health check-up examinees. This is a multicenter retrospective study. We enrolled 124 consecutive health check-up examinees who underwent colonoscopy. NAFLD and MAFLD were present in 58 and 63 examinees, respectively. Colorectal adenoma was diagnosed by biopsy. The impact of the MAFLD definition on the prevalence of colorectal adenoma was investigated by logistic regression, decision-tree, and random forest analyses. In logistic regression analysis, MAFLD was identified as the only independent factor associated with the presence of colorectal adenoma (OR 3.191, 95% CI 1.494–7.070, p = 0.003). MAFLD was also identified as the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (29 variable importance value). Among the three subtypes of MAFLD, non-obese MAFLD was the sole independent factor associated with the presence of colorectal adenoma (OR 3.351, 95% CI 1.589–7.262, p ≤ 0.001). Non-obese MAFLD was also the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (31 variable importance value). MAFLD, particularly non-obese MAFLD, is the most important factor associated with the presence of colorectal adenoma rather than NAFLD. Colonoscopy examination should be considered in patients with MAFLD, especially those who are non-obese.
- Published
- 2021
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