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6. Enhanced Artificial Intelligence Methods for Liver Steatosis Assessment Using Machine Learning and Color Image Processing: Liver Color Project.

Author

Gómez‐Gavara, Concepción, Bilbao, Itxarone, Piella, Gemma, Vazquez‐Corral, Javier, Benet‐Cugat, Berta, Pando, Elizabeth, Molino, José Andrés, Salcedo, María Teresa, Dalmau, Mar, Vidal, Laura, Esono, Daniel, Cordobés, Miguel Ángel, Bilbao, Ángela, Prats, Josa, Moya, Mar, Dopazo, Cristina, Mazo, Christopher, Caralt, Mireia, Hidalgo, Ernest, and Charco, Ramon

Subjects
COLOR image processing, ANALYSIS of colors, TEXTURE analysis (Image processing), FEATURE extraction, BRAIN death
Abstract

Background: The use of livers with significant steatosis is associated with worse transplantation outcomes. Brain death donor liver acceptance is mostly based on subjective surgeon assessment of liver appearance, since steatotic livers acquire a yellowish tone. The aim of this study was to develop a rapid, robust, accurate, and cost‐effective method to assess liver steatosis. Methods: From June 1, 2018, to November 30, 2023, photographs and tru‐cut needle biopsies were taken from adult brain death donor livers at a single university hospital for the study. All the liver photographs were taken by smartphones then color calibrated, segmented, and divided into patches. Color and texture features were then extracted and used as input, and the machine learning method was applied. This is a collaborative project between Vall d'Hebron University Hospital and Barcelona MedTech, Pompeu Fabra University, and is referred to as LiverColor. Results: A total of 192 livers (362 photographs and 7240 patches) were included. When setting a macrosteatosis threshold of 30%, the best results were obtained using the random forest classifier, achieving an AUROC = 0.74, with 85% accuracy. Conclusion: Machine learning coupled with liver texture and color analysis of photographs taken with smartphones provides excellent accuracy for determining liver steatosis. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Outcomes of liver transplantation for non-alcoholic steatohepatitis: A European Liver Transplant Registry study

Author

Haldar, Debashis, Kern, Barbara, Hodson, James, Armstrong, Matthew James, Adam, Rene, Berlakovich, Gabriela, Fritz, Josef, Feurstein, Benedikt, Popp, Wolfgang, Karam, Vincent, Muiesan, Paolo, O'Grady, John, Jamieson, Neville, Wigmore, Stephen J., Pirenne, Jacques, Malek-Hosseini, Seyed Ali, Hidalgo, Ernest, Tokat, Yaman, Paul, Andreas, Pratschke, Johann, Bartels, Michael, Trunecka, Pavel, Settmacher, Utz, Pinzani, Massimo, Duvoux, Christophe, Newsome, Philip Noel, and Schneeberger, Stefan

Published
2019
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20. Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Registry (ELTR): An Extension Study

Author

Adam, René, Karam, Vincent, Cailliez, Valérie, Trunečka, Pavel, Samuel, Didier, Tisone, Giuseppe, Němec, Petr, Soubrane, Olivier, Schneeberger, Stefan, Gridelli, Bruno, Bechstein, Wolf O., Risaliti, Andrea, Line, Pal-Dag, Vivarelli, Marco, Rossi, Massimo, Pirenne, Jacques, Klempnauer, Jurgen L., Rummo, Aleh, Di Benedetto, Fabrizio, Zieniewicz, Krzysztof, Troisi, Roberto, Paul, Andreas, Vali, Toomas, Kollmar, Otto, Boudjema, Karim, Hoti, Emir, Colledan, Michele, Pratschke, Johan, Lang, Hauke, Popescu, Irinel, Ericzon, Bo-Goran, Strupas, Kestutis, De Simone, Paolo, Kochs, Eberhard, Heyd, Bruno, Gugenheim, Jean, Pinna, Antonio D., Bennet, William, Kazimi, Mirjalal, Bachellier, Philippe, Wigmore, Stephen J., Rasmussen, Allan, Clavien, Pierre-Alain, Hidalgo, Ernest, O’Grady, John G., Zamboni, Frausto, Kilic, Murat, and Duvoux, Christophe

Published
2019
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22. AEMET-γSREPS

Author

Callado I Pallarés, Alfons, primary, Escribà Ayerbe, Pau, additional, García-Moya Zapata, José Antonio, additional, Compte Rovirola, Marc, additional, Gil Oliva, David, additional, Martín, A., additional, Rodríguez, J., additional, and Werner Hidalgo, Ernest, additional

Published
2018
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27. High intrapatient variability of tacrolimus exposure associated with poorer outcomes in liver transplantation

Author

Dopazo, Cristina, primary, Bilbao, Itxarone, additional, García, Sonia, additional, Gómez‐Gavara, Concepción, additional, Caralt, Mireia, additional, Campos‐Varela, Isabel, additional, Castells, Lluis, additional, Hidalgo, Ernest, additional, Moreso, Francisco, additional, Montoro, Bruno, additional, and Charco, Ramón, additional

Published
2022
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28. HCC recurrence in HCV‐infected patients after liver transplantation: SiLVER Study reveals benefits of sirolimus in combination with CNIs – a post‐hoc analysis

Author

Werner, Jens M., Hornung, Matthias, Krah, Rubertha, Götz, Markus, Schnitzbauer, Andreas A., Schlitt, Hans J., Geissler, Edward K., Zülke, Carl, Lamby, Philipp E., Proneth, Andrea, Duvoux, Christophe, Burra, Patrizia, Jauch, Karl‐Walter, Rentsch, Markus, Ganten, Tom M., Schmidt, Jan, Settmacher, Utz, Heise, Michael, Rossi, Giorgio, Cillo, Umberto, Kneteman, Norman, Adam, René, Hoek, Bart, Bachellier, Philippe, Wolf, Philippe, Rostaing, Lionel, Bechstein, Wolf O., Rizell, Magnus, Powell, James, Hidalgo, Ernest, Gugenheim, Jean, Wolters, Heiner, Brockmann, Jens, Roy, André, Mutzbauer, Ingrid, Schlitt, Angela, Beckebaum, Susanne, Graeb, Christian, Nadalin, Silvio, Valente, Umberto, Turrión, Victor Sánchez, Jamieson, Neville, Scholz, Tim, Colledan, Michele, Fändrich, Fred, Becker, Thomas, Söderdahl, Gunnar, Chazouillères, Olivier, Mäkisalo, Heikki, Pageaux, Georges‐Philippe, Steininger, Rudolf, Soliman, Thomas, Jong, Koert P., Pirenne, Jacques, Margreiter, Raimund, Pratschke, Johann, Pinna, Antonio D., Hauss, Johann, Schreiber, Stefan, Strasser, Simone, Klempnauer, Jürgen, Troisi, Roberto I., Bhoori, Sherrie, Lerut, Jan, Bilbao, Itxarone, Klein, Christian G., Königsrainer, Alfred, Otto, Gerd, Mazzaferro, Vincenzo, Neuhaus, Peter, Werner, J, Hornung, M, Krah, R, Gotz, M, Schnitzbauer, A, Schlitt, H, Geissler, E, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Otto, G, Mazzaferro, V, and Neuhaus, P

Subjects
Silver Study, medicine.medical_specialty, Carcinoma, Hepatocellular, Silver, direct-acting antiviral agents, medicine.medical_treatment, 610 Medizin, Subgroup analysis, 030230 surgery, Liver transplantation, Gastroenterology, Group B, 03 medical and health sciences, HEPATOCELLULAR-CARCINOMA, hepatitis C virus infection, hepatocellular carcinoma, liver transplantation, 0302 clinical medicine, Internal medicine, Post-hoc analysis, medicine, Humans, Sirolimus, direct-acting antiviral agent, ddc:610, Transplantation, business.industry, Liver Neoplasms, Immunosuppression, medicine.disease, Hepatitis C, digestive system diseases, Calcineurin, Hepatocellular carcinoma, 030211 gastroenterology & hepatology, Neoplasm Recurrence, Local, business, medicine.drug
Abstract

Factors affecting outcomes in liver transplant (LTx) recipients with hepatocellular carcinoma (HCC) and hepatitis C viral (HCV) infection include the choice of immunosuppression. Here, we analyzed the HCV+ subgroup of patients from the randomized controlled, international SiLVER Study. We performed a post hoc analysis of 166 HCV+ SiLVER Study patients regarding HCC outcome after LTx. Control patients (group A: n=88) received mTOR inhibitor (mTORi)-free, calcineurin inhibitor (CNI)-based versus sirolimus-based immunosuppression (group B: n=78). We found no significant difference regarding HCV-RNA titers between group A and B. Since no effect in group B could be due to variable sirolimus dosing, we split group B into patients receiving sirolimus-based immunosuppression+CNIs for >50% (B1; n=44) or

Published
2020
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30. Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma: A Randomized, Multicenter, Open-Label Phase 3 Trial

Author

Geissler, Edward K., Schnitzbauer, Andreas A., Zülke, Carl, Lamby, Philipp E., Proneth, Andrea, Duvoux, Christophe, Burra, Patrizia, Jauch, Karl-Walter, Rentsch, Markus, Ganten, Tom M., Schmidt, Jan, Settmacher, Utz, Heise, Michael, Rossi, Giorgio, Cillo, Umberto, Kneteman, Norman, Adam, René, van Hoek, Bart, Bachellier, Philippe, Wolf, Philippe, Rostaing, Lionel, Bechstein, Wolf O., Rizell, Magnus, Powell, James, Hidalgo, Ernest, Gugenheim, Jean, Wolters, Heiner, Brockmann, Jens, Roy, André, Mutzbauer, Ingrid, Schlitt, Angela, Beckebaum, Susanne, Graeb, Christian, Nadalin, Silvio, Valente, Umberto, Turrión, Victor Sánchez, Jamieson, Neville, Scholz, Tim, Colledan, Michele, Fändrich, Fred, Becker, Thomas, Söderdahl, Gunnar, Chazouillères, Olivier, Mäkisalo, Heikki, Pageaux, Georges-Philippe, Steininger, Rudolf, Soliman, Thomas, de Jong, Koert P., Pirenne, Jacques, Margreiter, Raimund, Pratschke, Johann, Pinna, Antonio D., Hauss, Johann, Schreiber, Stefan, Strasser, Simone, Klempnauer, Jürgen, Troisi, Roberto I., Bhoori, Sherrie, Lerut, Jan, Bilbao, Itxarone, Klein, Christian G., Königsrainer, Alfred, Mirza, Darius F., Otto, Gerd, Mazzaferro, Vincenzo, Neuhaus, Peter, and Schlitt, Hans J.

Published
2016
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34. Delayed sequential abdominal wall closure in pediatric liver transplantation to overcome “large for size” scenarios

Author

Molino, José Andrés, primary, Hidalgo, Ernest, additional, Quintero, Jesús, additional, Coma, Ana, additional, Ortega, Juan, additional, Juamperez, Javier, additional, Mercadal‐Hally, María, additional, Riera, Lluis, additional, Riaza, Lucia, additional, Bilbao, Itxarone, additional, Dopazo, Cristina, additional, Caralt, Mireia, additional, Pando, Elisabeth, additional, Gómez‐Gavara, Concepción, additional, and Charco, Ramón, additional

Published
2021
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37. Influence of donor and recipient gender on liver transplantation outcomes in Europe

Author

Germani, Giacomo, Zeni, Nicola, Zanetto, Alberto, Adam, René, Karam, Vincent, Belli, Luca S, O'Grady, John, Mirza, Darius, Klempnauer, Jurgen, Cherqui, Daniel, Pratschke, Johann, Jamieson, Neville, Salizzoni, Mauro, Hidalgo, Ernest, Lerut, Jan, Paul, Andreas, Garcia-Valdecasas, Juan Carlos, Rodríguez, Fernando San Juan, Villa, Erica, Burra, Patrizia, European Liver, Intestine Transplant Association (ELITA), UCL - SSS/IREC - Institut de recherche expérimentale et clinique, and UCL - (SLuc) Service de chirurgie et transplantation abdominale

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Medizin, Liver transplantation, Graft loss, outcomes, survival, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Female patient, medicine, gender, Humans, Survival rate, donor, Retrospective Studies, Hepatology, liver transplantation, business.industry, Potential risk, recipient, Graft Survival, Patient survival, Anthropometry, Middle Aged, Tissue Donors, Liver Transplantation, Europe, Survival Rate, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, business
Abstract

Background & Aims The impact of gender and donor/recipient gender mismatch on LT outcomes is controversial. The aim of this study was to compare outcomes of LT in Europe, using the ELTR database, between male and female recipients, including donor/recipient gender mismatch. Methods Recipient, donor and transplant characteristics were compared between male and female patients. Patient survival was compared between groups, and the impact of donor/recipient gender matching as well as donor and recipient anthropometric characteristics were evaluated as potential risk factors for post-LT death/graft loss. Results A total of 46,334 LT patients were evaluated (70.5% men and 29.5% women). Ten-year survival rate was significantly higher in female than in male recipients (66% vs 59%, P < .0001). At multivariate analysis, adjusted for indication to LT and type of graft, donor/recipient gender mismatch (HR 1.12, 95% CI 1.04-1.2; P = .003), donor age > 60 years (HR 1.09, 95% CI 1.01-1.18; P = .027) and recipient age (HR 1.02, 95% CI 1.1-1.02; P < .0001) were significantly associated with post-LT lower survival rate in men. Conversely in female recipients, donor BMI > 30 (HR 1.32, 95% CI 1.09-1.6; P = .005), donor age > 60 years (HR 1.15, 95% CI 1.01-1.32; P = .027) and recipient age (HR 1.02, 95% CI 1.01-1.02; P < .0001) were significantly associated with lower post-LT survival rate. Conclusions Donor/recipient gender mismatch in male recipients and the use of obese donor in female recipients are associated with reduced survival after LT. Therefore, the incorporation of donor and recipient anthropometric quantities in the allocation process should be a matter of further studies, as their matching can significantly influence long-term outcomes.

Published
2020

42. Invasión de polvo en la península ibérica: del 14 al 16 de marzo de 2022.

Author

CALBET, XAVIER, MARTÍNEZ RUBIO, MIGUEL ÁNGEL, ANDRÉS GARCÍA-VALERO, JUAN, GARCÍA-CASTRILLO RUIZ, GERARDO, HIDALGO, ERNEST WERNER, and BAÑÓN PEREGRÍN, LUIS MARIA

Subjects
PENINSULAS, WINDSTORMS, DUST, ISLANDS, METEOROLOGICAL precipitation, METEOROLOGY, MINERAL dusts, DUST storms
Abstract

Copyright of Tiempo y Clima is the property of Asociacion Meteorologica Espanola and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

46. Recurrent Pyogenic Cholangitis as an Unusual Indication for Liver Transplantation in a Center of a Western Country

Author

Gómez-Gavara, Concepción, primary, Gómez-Gavara, Concepción, additional, Castells, Lluís, additional, Campos-Varela, Isabel, additional, Pares Bofill, Berta, additional, Martín, Rocío, additional, Curell, Anna, additional, Dopazo, Cristina, additional, Pando, Elizabeth, additional, Caralt, Mireia, additional, Salcedo, M. Teresa, additional, Hidalgo, Ernest, additional, Bilbao, Itxarone, additional, and Charco, Ramón, additional

Published
2020
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47. Long-term patient and graft survival after liver transplantation for autoimmune hepatitis

Author

Heinemann, Melina, primary, Adam, René, additional, Haym, Marina Berenguer, additional, Mirza, Darius F., additional, Malek-Hosseini, Seyed Ali, additional, O’Grady, John G., additional, Hidalgo, Ernest, additional, Pratschke, Johann, additional, Boudjema, Karim, additional, Paul, Andreas, additional, Zieniewicz, Krzysztof, additional, Fronek, Jiri, additional, Weiss, Karl Heinz, additional, Karam, Vincent, additional, Duvoux, Christophe, additional, Lohse, Ansgar, additional, and Schramm, Christoph, additional

Published
2020
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48. Recipient Age for Liver Transplantation: Should It Be Limited? A Propensity Score Matching Analysis of a Large European Series

Author

Gómez-Gavara, Concepción, primary, Charco, Ramón, additional, Tapiolas, Ingrid, additional, Ridaura, Núria, additional, Campos-Varela, Isabel, additional, Dopazo, Cristina, additional, Pando, Elizabeth, additional, Caralt, Mireia, additional, Hidalgo, Ernest, additional, Castells, Lluís, additional, and Bilbao, Itxarone, additional

Published
2020
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