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274 results on '"Hidaka, Tomonori"'

1. Impaired humoral immunity following COVID-19 vaccination in HTLV-1 carriers

Author

Kameda, Takuro, Utsunomiya, Atae, Otsuka, Nobuaki, Kubuki, Yoko, Uchida, Taisuke, Shide, Kotaro, Kamiunten, Ayako, Nakano, Nobuaki, Tokunaga, Masahito, Miyazono, Takayoshi, Ito, Yoshikiyo, Yonekura, Kentaro, Kawakita, Toshiro, Akizuki, Keiichi, Tahira, Yuki, Karasawa, Masayoshi, Hidaka, Tomonori, Konagata, Ayaka, Taniguchi, Norifumi, Nagatomo, Yuma, Kogo, Fumiko, Shimizu, Koichiro, Ueno, Hiroaki, Ishizaki, Junzo, Takahashi, Naoya, Ikei, Yoshihiko, Hidaka, Michihiro, Yamaguchi, Hideki, and Shimoda, Kazuya

Published
2024
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2. CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma

Author

Kameda, Takuro, Shide, Kotaro, Kamiunten, Ayako, Kogure, Yasunori, Morishita, Daisuke, Koya, Junji, Tahira, Yuki, Akizuki, Keiichi, Yokomizo-Nakano, Takako, Kubota, Sho, Marutsuka, Kosuke, Sekine, Masaaki, Hidaka, Tomonori, Kubuki, Yoko, Kitai, Yuichi, Matsuda, Tadashi, Yoda, Akinori, Ohshima, Takayuki, Sugiyama, Midori, Sashida, Goro, Kataoka, Keisuke, Ogawa, Seishi, and Shimoda, Kazuya

Published
2022
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3. Whole-genome landscape of adult T-cell leukemia/lymphoma

Author

Kogure, Yasunori, Kameda, Takuro, Koya, Junji, Yoshimitsu, Makoto, Nosaka, Kisato, Yasunaga, Jun-ichirou, Imaizumi, Yoshitaka, Watanabe, Mizuki, Saito, Yuki, Ito, Yuta, McClure, Marni B., Tabata, Mariko, Shingaki, Sumito, Yoshifuji, Kota, Chiba, Kenichi, Okada, Ai, Kakiuchi, Nobuyuki, Nannya, Yasuhito, Kamiunten, Ayako, Tahira, Yuki, Akizuki, Keiichi, Sekine, Masaaki, Shide, Kotaro, Hidaka, Tomonori, Kubuki, Yoko, Kitanaka, Akira, Hidaka, Michihiro, Nakano, Nobuaki, Utsunomiya, Atae, Sica, R. Alejandro, Acuna-Villaorduna, Ana, Janakiram, Murali, Shah, Urvi, Ramos, Juan Carlos, Shibata, Tatsuhiro, Takeuchi, Kengo, Takaori-Kondo, Akifumi, Miyazaki, Yasushi, Matsuoka, Masao, Ishitsuka, Kenji, Shiraishi, Yuichi, Miyano, Satoru, Ogawa, Seishi, Ye, B. Hilda, Shimoda, Kazuya, and Kataoka, Keisuke

Published
2022
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5. Impact of a third dose of anti-SARS-CoV-2 vaccine in hematopoietic cell transplant recipients: A Japanese multicenter observational study

Author

Mori, Yasuo, primary, Uchida, Naoyuki, additional, Wake, Atsushi, additional, Miyawaki, Kohta, additional, Eto, Tetsuya, additional, Nakamura, Takayuki, additional, Iwasaki, Hiromi, additional, Ito, Yoshikiyo, additional, Tanimoto, Kazushi, additional, Katayama, Yuta, additional, Imamura, Yutaka, additional, Takahashi, Tsutomu, additional, Fujisaki, Tomoaki, additional, Kamimura, Tomohiko, additional, Choi, Ilseung, additional, Ishitsuka, Kenji, additional, Yoshimoto, Goichi, additional, Ogawa, Ryosuke, additional, Sugita, Junichi, additional, Takamatsu, Yasushi, additional, Tanimoto, Kazuki, additional, Hidaka, Tomonori, additional, Miyamoto, Toshihiro, additional, Akashi, Koichi, additional, and Nagafuji, Koji, additional

Published
2023
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6. Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma

Author

Kataoka, Keisuke, Iwanaga, Masako, Yasunaga, Jun-ichirou, Nagata, Yasunobu, Kitanaka, Akira, Kameda, Takuro, Yoshimitsu, Makoto, Shiraishi, Yuichi, Sato-Otsubo, Aiko, Sanada, Masashi, Chiba, Kenichi, Tanaka, Hiroko, Ochi, Yotaro, Aoki, Kosuke, Suzuki, Hiromichi, Shiozawa, Yusuke, Yoshizato, Tetsuichi, Sato, Yusuke, Yoshida, Kenichi, Nosaka, Kisato, Hishizawa, Masakatsu, Itonaga, Hidehiro, Imaizumi, Yoshitaka, Munakata, Wataru, Shide, Kotaro, Kubuki, Yoko, Hidaka, Tomonori, Nakamaki, Tsuyoshi, Ishiyama, Ken, Miyawaki, Shuichi, Ishii, Ryohei, Nureki, Osamu, Tobinai, Kensei, Miyazaki, Yasushi, Takaori-Kondo, Akifumi, Shibata, Tatsuhiro, Miyano, Satoru, Ishitsuka, Kenji, Utsunomiya, Atae, Shimoda, Kazuya, Matsuoka, Masao, Watanabe, Toshiki, and Ogawa, Seishi

Published
2018
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7. Early/prefibrotic primary myelofibrosis in patients who were initially diagnosed with essential thrombocythemia

Author

Kamiunten, Ayako, Shide, Kotaro, Kameda, Takuro, Ito, Masafumi, Sekine, Masaaki, Kubuki, Yoko, Hidaka, Tomonori, Akizuki, Keiichi, Tahira, Yuki, Toyama, Takanori, Kawano, Noriaki, Marutsuka, Kousuke, Maeda, Kouichi, Takeuchi, Masanori, Kawano, Hiroshi, Sato, Seiichi, Ishizaki, Junzo, Shimoda, Haruko, Yamashita, Kiyoshi, Matsuoka, Hitoshi, and Shimoda, Kazuya

Published
2018
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8. Table S2 from Single-Cell Analysis of the Multicellular Ecosystem in Viral Carcinogenesis by HTLV-1

Author

Koya, Junji, primary, Saito, Yuki, primary, Kameda, Takuro, primary, Kogure, Yasunori, primary, Yuasa, Mitsuhiro, primary, Nagasaki, Joji, primary, McClure, Marni B., primary, Shingaki, Sumito, primary, Tabata, Mariko, primary, Tahira, Yuki, primary, Akizuki, Keiichi, primary, Kamiunten, Ayako, primary, Sekine, Masaaki, primary, Shide, Kotaro, primary, Kubuki, Yoko, primary, Hidaka, Tomonori, primary, Kitanaka, Akira, primary, Nakano, Nobuaki, primary, Utsunomiya, Atae, primary, Togashi, Yosuke, primary, Ogawa, Seishi, primary, Shimoda, Kazuya, primary, and Kataoka, Keisuke, primary

Published
2023
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9. Supplementary Data from Single-Cell Analysis of the Multicellular Ecosystem in Viral Carcinogenesis by HTLV-1

Author

Koya, Junji, primary, Saito, Yuki, primary, Kameda, Takuro, primary, Kogure, Yasunori, primary, Yuasa, Mitsuhiro, primary, Nagasaki, Joji, primary, McClure, Marni B., primary, Shingaki, Sumito, primary, Tabata, Mariko, primary, Tahira, Yuki, primary, Akizuki, Keiichi, primary, Kamiunten, Ayako, primary, Sekine, Masaaki, primary, Shide, Kotaro, primary, Kubuki, Yoko, primary, Hidaka, Tomonori, primary, Kitanaka, Akira, primary, Nakano, Nobuaki, primary, Utsunomiya, Atae, primary, Togashi, Yosuke, primary, Ogawa, Seishi, primary, Shimoda, Kazuya, primary, and Kataoka, Keisuke, primary

Published
2023
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10. Data from Single-Cell Analysis of the Multicellular Ecosystem in Viral Carcinogenesis by HTLV-1

Author

Koya, Junji, primary, Saito, Yuki, primary, Kameda, Takuro, primary, Kogure, Yasunori, primary, Yuasa, Mitsuhiro, primary, Nagasaki, Joji, primary, McClure, Marni B., primary, Shingaki, Sumito, primary, Tabata, Mariko, primary, Tahira, Yuki, primary, Akizuki, Keiichi, primary, Kamiunten, Ayako, primary, Sekine, Masaaki, primary, Shide, Kotaro, primary, Kubuki, Yoko, primary, Hidaka, Tomonori, primary, Kitanaka, Akira, primary, Nakano, Nobuaki, primary, Utsunomiya, Atae, primary, Togashi, Yosuke, primary, Ogawa, Seishi, primary, Shimoda, Kazuya, primary, and Kataoka, Keisuke, primary

Published
2023
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13. Thrombohemorrhagic events, disease progression, and survival in polycythemia vera and essential thrombocythemia: a retrospective survey in Miyazaki prefecture, Japan

Author

Kamiunten, Ayako, Shide, Kotaro, Kameda, Takuro, Sekine, Masaaki, Kubuki, Yoko, Ito, Masafumi, Toyama, Takanori, Kawano, Noriaki, Marutsuka, Kousuke, Maeda, Kouichi, Takeuchi, Masanori, Kawano, Hiroshi, Sato, Seiichi, Ishizaki, Junzo, Akizuki, Keiichi, Tahira, Yuki, Shimoda, Haruko, Hidaka, Tomonori, Yamashita, Kiyoshi, Matsuoka, Hitoshi, and Shimoda, Kazuya

Published
2018
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14. Integrated genetic and clinical prognostic factors for aggressive adult T-cell leukemia/lymphoma

Author

Kameda, Takuro, primary, Kataoka, Keisuke, additional, Kamiunten, Ayako, additional, Hidaka, Michihiro, additional, Miyoshi, Hiroaki, additional, Nakano, Nobuaki, additional, Nosaka, Kisato, additional, Yoshimitsu, Makoto, additional, Yasunaga, Jun-ichirou, additional, Kogure, Yasunori, additional, Shide, Kotaro, additional, Miyahara, Masaharu, additional, Sakamoto, Takashi, additional, Akizuki, Keiichi, additional, Hidaka, Tomonori, additional, Kubuki, Yoko, additional, Koya, Junji, additional, Kawano, Noriaki, additional, Yamashita, Kiyoshi, additional, Kawano, Hiroshi, additional, Toyama, Takanori, additional, Maeda, Kouichi, additional, Marutsuka, Kosuke, additional, Imaizumi, Yoshitaka, additional, Kato, Koji, additional, Sugio, Takeshi, additional, Tokunaga, Masahito, additional, Tashiro, Yukie, additional, Takaori-Kondo, Akifumi, additional, Miyazaki, Yasushi, additional, Akashi, Koichi, additional, Ishitsuka, Kenji, additional, Matsuoka, Masao, additional, Ohshima, Koichi, additional, Watanabe, Toshiki, additional, Kitanaka, Akira, additional, Utsunomiya, Atae, additional, Ogawa, Seishi, additional, and Shimoda, Kazuya, additional

Published
2023
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15. Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis

Author

Shide, Kotaro, Kameda, Takuro, Kamiunten, Ayako, Oji, Asami, Ozono, Yoshinori, Sekine, Masaaki, Honda, Arata, Kitanaka, Akira, Akizuki, Keiichi, Tahira, Yuki, Nakamura, Kenichi, Hidaka, Tomonori, Kubuki, Yoko, Abe, Hiroo, Miike, Tadashi, Iwakiri, Hisayoshi, Tahara, Yoshihiro, Sueta, Mitsue, Hasuike, Satoru, Yamamoto, Shojiro, Nagata, Kenji, Ikawa, Masahito, and Shimoda, Kazuya

Published
2019
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16. Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator

Author

Kameda, Takuro, Shide, Kotaro, Yamaji, Takumi, Kamiunten, Ayako, Sekine, Masaaki, Taniguchi, Yasuhiro, Hidaka, Tomonori, Kubuki, Yoko, Shimoda, Haruko, Marutsuka, Kousuke, Sashida, Goro, Aoyama, Kazumasa, Yoshimitsu, Makoto, Harada, Taku, Abe, Hiroo, Miike, Tadashi, Iwakiri, Hisayoshi, Tahara, Yoshihiro, Sueta, Mitsue, Yamamoto, Shojiro, Hasuike, Satoru, Nagata, Kenji, Iwama, Atsushi, Kitanaka, Akira, and Shimoda, Kazuya

Published
2015
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17. Predictors of impaired antibody response after SARS‐CoV ‐2 mRNA vaccination in hematopoietic cell transplant recipients: A Japanese multicenter observational study

Author

Mori, Yasuo, primary, Uchida, Naoyuki, additional, Harada, Takuya, additional, Katayama, Yuta, additional, Wake, Atsushi, additional, Iwasaki, Hiromi, additional, Eto, Tetsuya, additional, Morishige, Satoshi, additional, Fujisaki, Tomoaki, additional, Ito, Yoshikiyo, additional, Kamimura, Tomohiko, additional, Takahashi, Tsutomu, additional, Imamura, Yutaka, additional, Tanimoto, Kazushi, additional, Ishitsuka, Kenji, additional, Sugita, Junichi, additional, Kawano, Noriaki, additional, Tanimoto, Kazuki, additional, Yoshimoto, Goichi, additional, Choi, Ilseung, additional, Hidaka, Tomonori, additional, Ogawa, Ryosuke, additional, Takamatsu, Yasushi, additional, Miyamoto, Toshihiro, additional, Akashi, Koichi, additional, and Nagafuji, Koji, additional

Published
2022
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18. Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers

Author

Kataoka, Keisuke, Shiraishi, Yuichi, Takeda, Yohei, Sakata, Seiji, Matsumoto, Misako, Nagano, Seiji, Maeda, Takuya, Nagata, Yasunobu, Kitanaka, Akira, Mizuno, Seiya, Tanaka, Hiroko, Chiba, Kenichi, Ito, Satoshi, Watatani, Yosaku, Kakiuchi, Nobuyuki, Suzuki, Hiromichi, Yoshizato, Tetsuichi, Yoshida, Kenichi, Sanada, Masashi, Itonaga, Hidehiro, Imaizumi, Yoshitaka, Totoki, Yasushi, Munakata, Wataru, Nakamura, Hiromi, Hama, Natsuko, Shide, Kotaro, Kubuki, Yoko, Hidaka, Tomonori, Kameda, Takuro, Masuda, Kyoko, Minato, Nagahiro, Kashiwase, Koichi, Izutsu, Koji, Takaori-Kondo, Akifumi, Miyazaki, Yasushi, Takahashi, Satoru, Shibata, Tatsuhiro, Kawamoto, Hiroshi, Akatsuka, Yoshiki, Shimoda, Kazuya, Takeuchi, Kengo, Seya, Tsukasa, Miyano, Satoru, and Ogawa, Seishi

Subjects
Gene expression -- Health aspects, Ligands (Biochemistry) -- Properties, Genetic variation -- Health aspects, Cancer -- Care and treatment, Molecular targeted therapy, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Successful treatment of many patients with advanced cancer using antibodies against programmed cell death 1 (PD-1; also known as PDCD1) and its ligand (PD-L1; also known as CD274) has highlighted the critical importance of PD-1/PD-L1-mediated immune escape in cancer development (1-6). However, the genetic basis for the immune escape has not been fully elucidated, with the exception of elevated PD-L1 expression by gene amplification and utilization of an ectopic promoter by translocation, as reported in Hodgkin and other B-cell lymphomas, as well as stomach adenocarcinoma (6-10). Here we show a unique genetic mechanism of immune escape caused by structural variations (SVs) commonly disrupting the 3' region of the PD-L1 gene. Widely affecting multiple common human cancer types, including adult T-cell leukaemia/lymphoma (27%), diffuse large B-cell lymphoma (8%), and stomach adenocarcinoma (2%), these SVs invariably lead to a marked elevation of aberrant PD-L1 transcripts that are stabilized by truncation of the 3'-untranslated region (UTR). Disruption of the Pd-l1 3'-UTR in mice enables immune evasion of EG7-OVA tumour cells with elevated Pd-l1 expression in vivo, which is effectively inhibited by Pd-1/Pd-l1 blockade, supporting the role of relevant SVs in clonal selection through immune evasion. Our findings not only unmask a novel regulatory mechanism of PD-L1 expression, but also suggest that PD-L1 3'-UTR disruption could serve as a genetic marker to identify cancers that actively evade anti-tumour immunity through PD-L1 overexpression., Structural variations, including translocations, inversions, tandem duplications, and deletions, are widely observed across cancer genomes (11,12). Of particular interest are those involving non-coding sequences recently reported for activation of several [...]

Published
2016

19. Efficacy of upfront high-dose chemotherapy plus rituximab followed by autologous peripheral blood stem cell transplantation for untreated high-intermediate-, and high-risk diffuse large B-cell lymphoma: a multicenter prospective phase II study (JSCT-NHL04)

Author

Murayama, Tohru, Fukuda, Takahiro, Okumura, Hirokazu, Sunami, Kazutaka, Sawazaki, Aiko, Maeda, Yoshinobu, Tsurumi, Hisashi, Uike, Naokuni, Hidaka, Tomonori, Takatsuka, Yoshifusa, Eto, Tetsuya, Tsuda, Hiroyuki, Fujisaki, Tomoaki, Miyamoto, Toshihiro, Tsuneyoshi, Naoko, Iyama, Satoshi, Nagafuji, Koji, and Harada, Mine

Published
2016
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20. Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma

Author

Kameda, Takuro, primary, Shide, Kotaro, additional, Tahira, Yuki, additional, Sekine, Masaaki, additional, Sato, Seiichi, additional, Ishizaki, Junzo, additional, Takeuchi, Masanori, additional, Akizuki, Keiichi, additional, Kamiunten, Ayako, additional, Shimoda, Haruko, additional, Toyama, Takanori, additional, Maeda, Kouichi, additional, Yamashita, Kiyoshi, additional, Kawano, Noriaki, additional, Kawano, Hiroshi, additional, Hidaka, Tomonori, additional, Yamaguchi, Hideki, additional, Kubuki, Yoko, additional, Kitanaka, Akira, additional, Matsuoka, Hitoshi, additional, and Shimoda, Kazuya, additional

Published
2022
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21. The effect of CARD11 mutation and HBZ expression accelerated lymphoproliferative diseases and formed the pathological basis for adult T-cell leukemia/lymphoma

Author

Shimoda, Kazuya, primary, Kameda, Takuro, additional, Shide, Kotaro, additional, Kamiunten, Ayako, additional, Kogure, Yasunori, additional, Morishita, Daisuke, additional, Koya, Junji, additional, Tahira, Yuki, additional, Akizuki, Keiichi, additional, Yokomizo-Nakano, Takako, additional, Kubota, Sho, additional, Marutsuka, Kosuke, additional, Sekine, Masaaki, additional, Hidaka, Tomonori, additional, Kubuki, Yoko, additional, Yoda, Akinori, additional, Ohshima, Takayuki, additional, Sugiyama, Midori, additional, Sashida, Goro, additional, Kataoka, Keisuke, additional, and Ogawa, Seishi, additional

Published
2022
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23. Single-Cell Analysis of the Multicellular Ecosystem in Viral Carcinogenesis by HTLV-1

Author

Koya, Junji, primary, Saito, Yuki, additional, Kameda, Takuro, additional, Kogure, Yasunori, additional, Yuasa, Mitsuhiro, additional, Nagasaki, Joji, additional, McClure, Marni B., additional, Shingaki, Sumito, additional, Tabata, Mariko, additional, Tahira, Yuki, additional, Akizuki, Keiichi, additional, Kamiunten, Ayako, additional, Sekine, Masaaki, additional, Shide, Kotaro, additional, Kubuki, Yoko, additional, Hidaka, Tomonori, additional, Kitanaka, Akira, additional, Nakano, Nobuaki, additional, Utsunomiya, Atae, additional, Togashi, Yosuke, additional, Ogawa, Seishi, additional, Shimoda, Kazuya, additional, and Kataoka, Keisuke, additional

Published
2021
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24. Potentiated activation of VLA-4 and VLA-5 accelerates proplatelet-like formation

Author

Matsunaga, Takuya, Fukai, Fumio, Kameda, Takuro, Shide, Kotaro, Shimoda, Haruko, Torii, Eri, Kamiunten, Ayako, Sekine, Masaaki, Yamamoto, Shojirou, Hidaka, Tomonori, Kubuki, Yoko, Yokokura, Shigeyuki, Uemura, Makiko, Matsuoka, Akihito, Waki, Fusako, Matsumoto, Kensuke, Kanaji, Nobuhiro, Ishii, Tomoya, Imataki, Osamu, Dobashi, Hiroaki, Bandoh, Shuji, and Shimoda, Kazuya

Published
2012
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26. Acute myeloid leukemia in clinical practice: a retrospective population-based cohort study in Miyazaki Prefecture, Japan

Author

Matsunaga, Takuya, Yamashita, Kiyoshi, Kubuki, Yoko, Toyama, Takanori, Imataki, Osamu, Maeda, Kouichi, Kawano, Noriaki, Satou, Seiichi, Kawano, Hiroshi, Ishizaki, Junzo, Yoshida, Shuro, Kameda, Takuro, Sasaki, Tadashi, Sekine, Masaaki, Kamiunten, Ayako, Taniguchi, Yasuhiro, Hidaka, Tomonori, Katayose, Keiko, K-Shimoda, Haruko, Shide, Kotaro, Yamamoto, Shojiro, Moritake, Hiroshi, Nunoi, Hiroyuki, Makino, Shigeyoshi, Kitanaka, Akira, Matsuoka, Hitoshi, and Shimoda, Kazuya

Published
2012
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27. Clinical features and treatment outcomes of isolated secondary central nervous system lymphomas in Miyazaki Prefecture

Author

Kawano, Noriaki, Ochiai, Hidenobu, Yoshida, Shuro, Yamashita, Kiyoshi, Shide, Kotaro, Shimoda, Haruko, Hidaka, Tomonori, Kubuki, Yoko, Katayose, Keiko, Toyama, Takanori, Kawano, Hiroshi, Matsuoka, Hitoshi, Ishizaki, Junzo, Maeda, Koichi, Satou, Seiichi, Yano, Tatsuhiko, Yamaguchi, Kenichiro, Takenaka, Katsuto, Shimao, Yoshiya, Oshima, Koichi, Ueda, Akira, and Shimoda, Kazuya

Published
2012
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28. CD3 and EBER double positive cells in bone marrow are a diagnostic aid for EBV-positive T-cell lymphoproliferative disorders of childhood

Author

Yamada, Yuri, Kamiunten, Ayako, Hidaka, Tomonori, Sekine, Masafumi, Marutsuka, Kousuke, Katayose, Keiko, Kubuki, Yoko, Iwakiri, Hisanori, Hasuike, Satoru, Tsuchimochi, Mai, Nakamura, Kenichi, Yamamoto, Shojirou, Otsubo, Yoshinori, Kusumoto, Norihisa, Eto, Toshiharu, Nagata, Kenji, Kitanaka, Akira, and Shimoda, Kazuya

Published
2012
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31. Real-World Data on Clinical Features, Outcomes, and Prognostic Factors in Multiple Myeloma from Miyazaki Prefecture, Japan

Author

Akizuki, Keiichi, primary, Matsuoka, Hitoshi, additional, Toyama, Takanori, additional, Kamiunten, Ayako, additional, Sekine, Masaaki, additional, Shide, Kotaro, additional, Kameda, Takuro, additional, Kawano, Noriaki, additional, Maeda, Kouichi, additional, Takeuchi, Masanori, additional, Kawano, Hiroshi, additional, Sato, Seiichi, additional, Ishizaki, Junzo, additional, Tahira, Yuki, additional, Shimoda, Haruko, additional, Hidaka, Tomonori, additional, Yamashita, Kiyoshi, additional, Kubuki, Yoko, additional, and Shimoda, Kazuya, additional

Published
2020
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32. Higher average chemotherapy dose intensity improves prognosis in patients with aggressive adult T‐cell leukemia/lymphoma

Author

Sekine, Masaaki, primary, Kameda, Takuro, additional, Shide, Kotaro, additional, Maeda, Kouichi, additional, Toyama, Takanori, additional, Kawano, Noriaki, additional, Takeuchi, Masanori, additional, Kawano, Hiroshi, additional, Sato, Seiichi, additional, Ishizaki, Junzo, additional, Kukita, Toshimasa, additional, Kamiunten, Ayako, additional, Akizuki, Keiichi, additional, Tahira, Yuki, additional, Shimoda, Haruko, additional, Hidaka, Tomonori, additional, Yamashita, Kiyoshi, additional, Matsuoka, Hitoshi, additional, Kitanaka, Akira, additional, Kubuki, Yoko, additional, and Shimoda, Kazuya, additional

Published
2020
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33. Whole-Genome Analysis of Adult T-Cell Leukemia/Lymphoma

Author

Kogure, Yasunori, primary, Kameda, Takuro, additional, Koya, Junji, additional, Kamiunten, Ayako, additional, Shide, Kotaro, additional, Hidaka, Tomonori, additional, Kubuki, Yoko, additional, Yoshimitsu, Makoto, additional, Nosaka, Kisato, additional, Imaizumi, Yoshitaka, additional, Watanabe, Mizuki, additional, Saito, Yuki, additional, McClure, Marni B, additional, Tabata, Mariko, additional, Shingaki, Sumito, additional, Yoshifuji, Kota, additional, Shiraishi, Yuichi, additional, Hidaka, Michihiro, additional, Utsunomiya, Atae, additional, Shah, Urvi A., additional, Acuna-Villaorduna, Ana, additional, Shastri, Aditi, additional, Sica, R. Alejandro, additional, Janakiram, Murali, additional, Ramos, Juan Carlos, additional, Shibata, Tatsuhiro, additional, Takaori-Kondo, Akifumi, additional, Miyazaki, Yasushi, additional, Matsuoka, Masao, additional, Ishitsuka, Kenji, additional, Ogawa, Seishi, additional, Ye, B. Hilda, additional, Shimoda, Kazuya, additional, and Kataoka, Keisuke, additional

Published
2020
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35. Corrigendum to “Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphomaˮ [Biochem. Biophys. Res. Commun. 485 (1) 2017 144–151]

Author

Shimosaki, Shunsuke, primary, Nakahata, Shingo, additional, Ichikawa, Tomonaga, additional, Kitanaka, Akira, additional, Kameda, Takuro, additional, Hidaka, Tomonori, additional, Kubuki, Yoko, additional, Kurosawa, Gene, additional, Zhang, Lilin, additional, Sudo, Yukio, additional, Shimoda, Kazuya, additional, and Morishita, Kazuhiro, additional

Published
2020
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36. Clinical characteristics of adult T-cell leukemia/lymphoma infiltration in the gastrointestinal tract

Author

Miike, Tadashi, primary, Kawakami, Hiroshi, additional, Kameda, Takuro, additional, Yamamoto, Shojiro, additional, Tahara, Yoshihiro, additional, Hidaka, Tomonori, additional, Kubuki, Yoko, additional, Yorita, Kenji, additional, Akiyama, Yutaka, additional, Arimura, Yasuji, additional, Kubota, Yoshimasa, additional, Kataoka, Hiroaki, additional, and Shimoda, Kazuya, additional

Published
2020
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37. Neoplastic fibrocytes play an essential role in bone marrow fibrosis in Jak2V617F-induced primary myelofibrosis mice

Author

Ozono, Yoshinori, primary, Shide, Kotaro, additional, Kameda, Takuro, additional, Kamiunten, Ayako, additional, Tahira, Yuki, additional, Sekine, Masaaki, additional, Akizuki, Keiichi, additional, Nakamura, Kenichi, additional, Iwakiri, Hisayoshi, additional, Sueta, Mitsue, additional, Hidaka, Tomonori, additional, Kubuki, Yoko, additional, Yamamoto, Shojiro, additional, Hasuike, Satoru, additional, Sawaguchi, Akira, additional, Nagata, Kenji, additional, and Shimoda, Kazuya, additional

Published
2020
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38. Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms

Author

Shide, Kotaro, primary, Kameda, Takuro, primary, Kamiunten, Ayako, primary, Ozono, Yoshinori, primary, Tahira, Yuki, primary, Yokomizo-Nakano, Takako, primary, Kubota, Sho, primary, Ono, Masaya, primary, Ikeda, Kazuhiko, primary, Sekine, Masaaki, primary, Akizuki, Keiichi, primary, Nakamura, Kenichi, primary, Hidaka, Tomonori, primary, Kubuki, Yoko, primary, Iwakiri, Hisayoshi, primary, Hasuike, Satoru, primary, Nagata, Kenji, primary, Sashida, Goro, primary, and Shimoda, Kazuya, primary

Published
2020
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39. Diffuse large B-cell lymphoma of the gallbladder arised 8 years after malignant lymphoma of the right testis: A case report and literature review

Author

Kai, Kengo, primary, Hamada, Takeomi, additional, Hiyoshi, Masahide, additional, Imamura, Naoya, additional, Yano, Koichi, additional, Nagano, Motoaki, additional, Kai, Masahiro, additional, Hidaka, Tomonori, additional, Shimoda, Kazuya, additional, Haruyama, Yukihiro, additional, Kataoka, Hiroaki, additional, and Nanashima, Atsushi, additional

Published
2020
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40. Uterine relapse of Philadelphia chromosome-negative acute lymphoblastic leukemia

Author

Kawano, Noriaki, primary, Maeda, Tetsuo, additional, Kawano, Sayaka, additional, Naghiro, Yuri, additional, Takami, Akiyoshi, additional, Tochigi, Taro, additional, Nakaike, Takashi, additional, Yamashita, Kiyoshi, additional, Kodama, Takao, additional, Marutsuka, Kosuke, additional, Sugimoto, Yuka, additional, Imamura, Toshihiko, additional, Mori, Yasuo, additional, Ochiai, Hidenobu, additional, Hidaka, Tomonori, additional, Shimoda, Kazuya, additional, Mashiba, Koichi, additional, and Kikuchi, Ikuo, additional

Published
2020
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41. Depletion of Neoplastic CD11b Positive Cells in Jak2V617F Mutant Mice Reduced Fibrocytes in Bone Marrow and Improved Myelofibrosis

Author

Ozono, Yoshinori, primary, Shide, Kotaro, primary, Kameda, Takuro, primary, Kamiunten, Ayako, primary, Tahira, Yuki, primary, Sekine, Masaaki, primary, Akizuki, Keiichi, primary, Nakamura, Kenichi, primary, Iwakiri, Hisayoshi, primary, Hidaka, Tomonori, primary, Kubuki, Yoko, primary, Hasuike, Satoru, primary, Toyoshima, Fumiyo, primary, Sawaguchi, Akira, primary, Nagata, Kenji, primary, and Shimoda, Kazuya, primary

Published
2019
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42. The Role of Calreticulin in Normal Hematopoiesis and Neoplastic Hematopoiesis of Myeloproliferative Neoplasms

Author

Shide, Kotaro, primary, Kameda, Takuro, primary, Kamiunten, Ayako, primary, Ozono, Yoshinori, primary, Tahira, Yuki, primary, Sekine, Masaaki, primary, Ono, Masaya, primary, Yokomizo, Takako, primary, Kubota, Sho, primary, Akizuki, Keiichi, primary, Kubuki, Yoko, primary, Hidaka, Tomonori, primary, Sashida, Goro, primary, and Shimoda, Kazuya, primary

Published
2019
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46. Haploinsufficiency of CALR Confers Hematopoietic Stem Cells (HSCs) with a Clonal Advantage over Wild-Type Cells, and, in Setting of Myeloproliferative Neoplasms, Compensates for the Functions of HSCs Impaired By the Calr Mutation

Author

Shide, Kotaro, primary, Kameda, Takuro, additional, Kamiunten, Ayako, additional, Sekine, Masaaki, additional, Ozono, Yoshinori, additional, Yokomizo, Takako, additional, Akizuki, Keiichi, additional, Tahira, Yuki, additional, Kubuki, Yoko, additional, Hidaka, Tomonori, additional, Sashida, Goro, additional, and Shimoda, Kazuya, additional

Published
2018
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47. TET2 Mutation Associated with Organ Infiltrations in ATLL

Author

Kameda, Takuro, primary, Shide, Kotaro, additional, Kamiunten, Ayako, additional, Tahira, Yuki, additional, Akizuki, Keiichi, additional, Sekine, Masaaki, additional, Hidaka, Tomonori, additional, Kubuki, Yoko, additional, Hidaka, Michihiro, additional, Utsunomiya, Atae, additional, Ohshima, Takayuki, additional, Kataoka, Keisuke, additional, Ogawa, Seishi, additional, and Shimoda, Kazuya, additional

Published
2018
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48. Higher average chemotherapy dose intensity improves prognosis in patients with aggressive adult T‐cell leukemia/lymphoma.

Author

Sekine, Masaaki, Kameda, Takuro, Shide, Kotaro, Maeda, Kouichi, Toyama, Takanori, Kawano, Noriaki, Takeuchi, Masanori, Kawano, Hiroshi, Sato, Seiichi, Ishizaki, Junzo, Kukita, Toshimasa, Kamiunten, Ayako, Akizuki, Keiichi, Tahira, Yuki, Shimoda, Haruko, Hidaka, Tomonori, Yamashita, Kiyoshi, Matsuoka, Hitoshi, Kitanaka, Akira, and Kubuki, Yoko

Subjects
ADULT T-cell leukemia, CANCER chemotherapy, T-cell lymphoma, LYMPHOMAS, PROGNOSIS
Abstract

Objective and Method: Adult T‐cell leukemia/lymphoma (ATL) is an aggressive peripheral T‐cell lymphoma with poor prognosis. We retrospectively reviewed the medical records of 312 patients with aggressive ATL and analyzed the effect of chemotherapy dose intensity on prognosis in clinical practice. Result: As first‐line therapy, 62 patients underwent best supportive care (BSC) or single‐agent chemotherapy, and 235 underwent intensive chemotherapy. The median survival time (MST) was 0.58 years in the 312 total patients, and 0.13 years and 0.75 years in the BSC/single‐agent chemotherapy group and intensive chemotherapy group, respectively. The median average relative dose intensity (ARDI) of patients who received intensive chemotherapy was 60%. We divided patients into 3 groups according to ARDI. Those in the top tertile of ARDI (ARDI ≥ 75%, n = 82) had better overall survival compared with those in the intermediate tertile (45% ≤ ARDI < 75%, n = 79) (P <.0001), with MSTs of 4.69 and 0.75 years, respectively. The occurrence of organ dysfunction and infectious complications was comparable between the two ARDI groups. Conclusion: Higher ARDI improves prognosis in patients with aggressive ATL in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Ursodeoxycholic acid markedly promotes the absorption of microemulsion‐formulated cyclosporine A: A case report.

Author

Takeshima, Hidemi, Yoshikawa, Naoki, Akizuki, Keiichi, Hidaka, Tomonori, Shimoda, Kazuya, and Ikeda, Ryuji

Subjects
APLASTIC anemia, CYCLOSPORINE, BILE acids, DRUG interactions, DRUG monitoring
Abstract

What is known and objective: Cyclosporine A (CyA) causes intrahepatic biliary stasis via inhibition of bile acid excretion through the bile salt export pump. We report a case of a patient in whom ursodeoxycholic acid (UDCA) markedly promoted the absorption of microemulsion‐formulated CyA. Case summary: The patient was a 22‐year‐old Japanese man diagnosed with stage 3 aplastic anaemia. He was treated with CyA, and 2 h post‐dose (C2) was increased by UDCA. What is new and conclusion: A remarkable interaction was observed between CyA and UDCA. This is a valuable finding for improving the treatment strategies for haematological disorders. [ABSTRACT FROM AUTHOR]

Published
2022
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