Search

Your search keyword '"Hichem Lakhal"' showing total 8 results
Start Over Author "Hichem Lakhal"
8 results on '"Hichem Lakhal"'

1. Triterpenes from Salvia argentea var. aurasiaca and their antibacterial and cytotoxic activities

Author

Sophie C. Gangloff, Hamid Morjani, Hichem Lakhal, Zahia Kabouche, Djemaa Berrehal, Amin Abedini, Meryem Lehbili, Ahmed Kabouche, Sara Bechkri, Laurence Voutquenne-Nazabadioko, Abdulmagid Alabdul Magid, Université frères Mentouri Constantine I (UMC), Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Biomatériaux et inflammation en site osseux - EA 4691 (BIOS), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV), Université de Reims Champagne-Ardenne (URCA), Biospectroscopie Translationnelle - EA 7506 (BIOSPECT), PERRON, Brigitte, Université Mentouri-Constantine (LOST), Département de chimie, SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), and Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Serial dilution, [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, Phytochemicals, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], medicine.disease_cause, 01 natural sciences, Ursane triterpenes, Terpene, chemistry.chemical_compound, Drug Discovery, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Cytotoxic T cell, Salvia, Traditional medicine, biology, Salvia argentea L. var. aurasiaca, [PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Molecular Structure, Chemistry, General Medicine, Anti-Bacterial Agents, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Staphylococcus aureus, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], [SDV.BBM.BP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [SDV.CAN]Life Sciences [q-bio]/Cancer, Antineoplastic Agents, [SDV.CAN] Life Sciences [q-bio]/Cancer, medicine, Acetone, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Humans, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, Pharmacology, Lamiaceae, Bacteria, 010405 organic chemistry, Plant Components, Aerial, biology.organism_classification, Triterpenes, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Salvia argentea, Algeria, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, K562 Cells
Abstract

International audience; Five undescribed ursane-type triterpenes, identified as 1β,3β,15α-trihydroxy-urs-9(11)-12-diene (1), 1β,3β,15α,28-tetrahydroxy-urs-9(11),12-diene (2), 1β,3β-dihydroxy-urs-9(11),12-dien-28-al (3), 1β,3β,7β,15α,28-pentahydroxy-urs-12-ene (4), and 1β,3β,15α-trihydroxy-urs-11-en-28-al (5), together with five known compounds (6–10), were isolated from the acetone extract of the dried aerial parts of Salvia argentea L. var. aurasiaca (Pomel) Batt. et Trab. (Lamiaceae). Structures were elucidated on the basis of extensive spectroscopic analysis including HR-ESI-MS, 1D- and 2D-NMR techniques and comparison with literature data. The antibacterial evaluation of compounds 1–10 of the acetone extract of the dried aerial parts, in addition to nine compounds (11–19) previously isolated from the extract of the fresh aerial parts, by bioautography on Staphylococcus aureus followed by the determination of MIC values of active compounds by serial dilution technique against five bacteria, revealed that two compounds have an antibacterial effect comparable to antibiotics.The cytotoxic activity evaluation of compounds 1–19 showed that Six compounds exhibited an antiproliferative activity against K562 and HT1080 cells with IC50 values ranging from 30.25 to 70.32 μM.

Published
2019
Full Text
View/download PDF

2. Triterpenoids from Salvia argentea var. aurasiaca (Pomel) Batt. & Trab. and their chemotaxonomic significance

Author

Hichem Lakhal, Zahia Kabouche, Dominique Harakat, Ahmed Kabouche, Laurence Voutquenne-Nazabadioko, Abdulmagid Alabdul Magid, Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Mentouri-Constantine (LOST), and Département de chimie

Subjects
Exudate, Molecular Conformation, Trab, Plant Science, Horticulture, Salvia, 01 natural sciences, Biochemistry, Hydroxylation, chemistry.chemical_compound, Triterpenoid, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Botany, medicine, [CHIM]Chemical Sciences, Molecular Biology, biology, Salvia argentea L. var. aurasiaca, 010405 organic chemistry, Ursane triterpenoids, Stereoisomerism, General Medicine, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, biology.organism_classification, Triterpenes, 0104 chemical sciences, Chemotaxonomy, 010404 medicinal & biomolecular chemistry, chemistry, Salvia argentea, medicine.symptom
Abstract

International audience; Ten triterpenoids were isolated from the exudate of Salvia argentea L. var. aurasiaca (Pomel) Batt. & Trab. Their structures were elucidated by 1D and 2D NMR and HRESIMS analyses as 11α-methoxyurs-12-ene-1β,3β,15α-triol (1), urs-12-ene-1β,3β,11α,15α-tetraol (2), 11α-methoxyurs-12-ene-1β,3β-diol (3), 1β,3β,15α-trihydroxy-11α-methoxyurs-12-en-28-al (4), 1β,3β,15α-trihydroxyurs-12-en-28-al (5), urs-12-ene-1β,3β,15α,28-tetraol (6), 11α-methoxyurs-12-ene-1β,3β,28-triol (7), 13β,28-epoxyurs-12-ene-1β,3β-diol (8), urs-12-ene-3β,7β,15α,28-tetraol (9) and olean-12-ene-3β,7β,15α,28-tetraol (10). A chemotaxonomic survey of the triterpenoids of Salvia species show that triterpenoids from the exudate of S. argentea var. aurasiaca (Pomel) Batt. & Trab., provide some features, such as hydroxylation at C-15, and hydroxylation at C-7. On this basis, S. argentea L. var. aurasiaca (Pomel) Batt. & Trab., is quite different from S. argentea L.

Published
2014
Full Text
View/download PDF

3. ANTIOXIDANT ACTIVITY AND FLAVONOIDS OF Stachys ocymastrum

Author

Zahia Kabouche, Gulacti Topcu, S. Laggoune, Ahmed Kabouche, Tarek Boudiar, Hichem Lakhal, and TOPÇU, GÜLAÇTI

Subjects
Antioxidant, Traditional medicine, Chemistry, LAKHAL H., BOUDIAR T., KABOUCHE A., LAGGOUNE S., KABOUCHE Z., Topcu G., -ANTIOXIDANT ACTIVITY AND FLAVONOIDS OF Stachys ocymastrum-, CHEMISTRY OF NATURAL COMPOUNDS, cilt.46, ss.964-965, 2011, medicine.medical_treatment, medicine, Plant Science, General Chemistry, Stachys ocymastrum, General Biochemistry, Genetics and Molecular Biology
Published
2011

4. New sesquiterpene lactone and other constituents from Centaurea sulphurea (Asteraceae)

Author

Hichem, Lakhal, Tarek, Boudiar, Ahmed, Kabouche, Zahia, Kabouche, Rachid, Touzani, and Christian, Bruneau

Subjects
Flavonoids, Molecular Structure, Centaurea, Sesquiterpenes
Abstract

Five known flavonoids (1-5) and three sesquiterpene lactones (6-8) are reported for the first time from the endemic species Centaurea sulphurea Willd. (Asteraceae). Compound 7 is a new heliangolide (6R, 7R, 8S, 3'R)-8alpha-(3',4'-dihydroxy-methylene-2'-butanoyloxy)-15-oxo-helianga-1 (10), 4(5), 11(13)-trien-6,12-olide, named as sulphurein.

Published
2010

5. A New Alkaloid and Flavonoids from the Aerial Parts of Euphorbia guyoniana

Author

Boudiar, Tarek, Hichem, Lakhal, Khalfallah, A., Kabouche, Ahmed, Kabouche, Zahia, Zahia, Brouard, Ignacio, Bermejo, Jaime, Bruneau, Christian, Boudiar, Tarek, Hichem, Lakhal, Khalfallah, A., Kabouche, Ahmed, Kabouche, Zahia, Zahia, Brouard, Ignacio, Bermejo, Jaime, and Bruneau, Christian

Abstract

One novel alkaloid, 1,5-diphenyl-3-styryl-2-pyrazoline 1, in addition with six known flavonoids namely, kaempferol, kaempferol 3-O-glucoside, kaempferol 3-rutinoside, quercetin, quercetin 3-O-glucoside, and rutin, were isolated from the aerial parts of Euphorbia guyoniana. Their structures were established on the basis of physical and spectroscopic analysis, and by comparison with the literature data.

Published
2010

8. New Sesquiterpene Lactone and Other Constituents from Centaurea sulphurea (Asteraceae)

Author

Ahmed Kabouche, Hichem Lakhal, Rachid Touzani, Tarek Boudiar, Christian Bruneau, and Zahia Kabouche

Subjects
Pharmacology, chemistry.chemical_classification, Plant composition, Plant Science, General Medicine, Biology, Asteraceae, Sesquiterpene, biology.organism_classification, Sesquiterpene lactone, Centaurea sulphurea, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Centaurea, Drug Discovery, Botany, Endemism
Abstract

Five known flavonoids (1-5) and three sesquiterpene lactones (6-8) are reported for the first time from the endemic species Centaurea sulphurea Willd. (Asteraceae). Compound 7 is a new heliangolide (6 R, 7 R, 8 S, 3' R)-8α-(3’,4’-dihydroxy-methylene-2’-butanoyloxy)-15-oxo-helianga-1(10), 4(5), 11(13)-trien-6,12-olide, named as sulphurein.

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results