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205 results on '"Hibbs D"'

8. Surveillance for azole resistance in clinical and environmental isolates of Aspergillus fumigatus in Australia and cyp51A homology modelling of azole-resistant isolates

Author

Talbot, J., Subedi, S., Halliday, C., Hibbs, D., Lai, F., Lopez-Ruiz, Fran, Harper, L., Park, R., Cuddy, W., Biswas, C., Cooley, L., Carter, D., Sorrell, T., Barrs, V., Chen, S., Talbot, J., Subedi, S., Halliday, C., Hibbs, D., Lai, F., Lopez-Ruiz, Fran, Harper, L., Park, R., Cuddy, W., Biswas, C., Cooley, L., Carter, D., Sorrell, T., Barrs, V., and Chen, S.

Abstract

Background: The prevalence of azole resistance in Aspergillus fumigatus is uncertain in Australia. Azole exposure may select for resistance. We investigated the frequency of azole resistance in a large number of clinical and environmental isolates. Methods: A. fumigatus isolates [148 human, 21 animal and 185 environmental strains from air (n=6) and azole-exposed (n=64) or azole-naive (n=115) environments] were screened for azole resistance using the VIPcheckTM system. MICs were determined using the SensititreTM YeastOne YO10 assay. Sequencing of the Aspergillus cyp51A gene and promoter region was performed for azole-resistant isolates, and cyp51A homology protein modelling undertaken. Results: Non-WT MICs/MICs at the epidemiological cut-off value of one or more azoles were observed for 3/148 (2%) human isolates but not amongst animal, or environmental, isolates. All three isolates grew on at least one azole-supplemented well based on VIPcheckTM screening. For isolates 9 and 32, the itraconazole and posaconazole MICs were 1 mg/L (voriconazole MICs 0.12 mg/L); isolate 129 had itraconazole, posaconazole and voriconazole MICs of >16, 1 and 8 mg/L, respectively. Soil isolates from azole-exposed and azole-naive environments had similar geometric mean MICs of itraconazole, posaconazole and voriconazole (P>0.05). A G54R mutation was identified in the isolates exhibiting itraconazole and posaconazole resistance, and the TR34/L98H mutation in the pan-azole-resistant isolate. cyp51A modelling predicted that the G54R mutation would prevent binding of itraconazole and posaconazole to the haem complex. Conclusions: Azole resistance is uncommon in Australian clinical and environmental A. fumigatus isolates; further surveillance is indicated.

Published
2018

16. Mixed-severity fire regimes: lessons and hypotheses from the Klamath-Siskiyou Ecoregion

Author

Halofsky, J. E., primary, Donato, D. C., additional, Hibbs, D. E., additional, Campbell, J. L., additional, Cannon, M. Donaghy, additional, Fontaine, J. B., additional, Thompson, J. R., additional, Anthony, R. G., additional, Bormann, B. T., additional, Kayes, L. J., additional, Law, B. E., additional, Peterson, D. L., additional, and Spies, T. A., additional

Published
2011
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40. L'aulne rouge. Un espece d'avenir en France

Author

Hibbs, D., TEISSIER Du CROS, Eric, Gauvin, J., Poursat, Patrick, Unité de Recherches Forestières Méditerranéennes (URFM), Institut National de la Recherche Agronomique (INRA), Unité technique biomasse, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Published
1993

46. bis(1,3-Benzothiazole-2-thiolato-S)-mercury(ii)

Author

Sammon, C., Raper, E. S., Mansor, R., Hursthouse, Michael B., Hibbs, D. E., Constable, C. P., Coles, Simon J., Bell, N. A., Sammon, C., Raper, E. S., Mansor, R., Hursthouse, Michael B., Hibbs, D. E., Constable, C. P., Coles, Simon J., and Bell, N. A.

Published
1997
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47. Dibromo-bis(1,3-thiazolidine-2-thione)-mercury(ii)

Author

Sammon, C., Raper, E. S., Mansor, R., Hursthouse, Michael B., Hibbs, D. E., Constable, C. P., Coles, Simon J., Bell, N. A., Sammon, C., Raper, E. S., Mansor, R., Hursthouse, Michael B., Hibbs, D. E., Constable, C. P., Coles, Simon J., and Bell, N. A.

Published
1997
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50. Stable Plant Communities in the Pacific Northwest.

Author

Nesmith, J. C. B., Shatford, J. P., and Hibbs, D. E.

Abstract

The application of stable low-growing plant communities as a tool in right-of-way (ROW) management is new in the Pacific Northwest. The development and use of this approach has been primarily in northeastern North America. We initiated a multi-year program to assess the application of this method to rights-of-way in the highly productive western hemlock zone of the Pacific Northwest. Working in the western Cascade Mountains of Oregon and Washington, we found a mix of deciduous and coniferous trees growing in established electric utility rights-of-way that had been treated 3 to 4 years earlier. To identify types of species that were effective in limiting regeneration of trees, we examined gap closure processes in rights-of-way where trees and tall-growing shrubs had been removed. We also examined the ability of some common low-growing shrub species to form dense thickets of vegetation. Gaps were most quickly closed by species capable of rapid horizontal spread through vegetative reproduction. Several of the common clonal shrubs found on the ROWs were also capable of forming dense thickets of vegetation. Thus, while there are necessarily differences at the species level between the western moist coniferous zone and the eastern deciduous zone, the importance of vegetative reproduction holds. [ABSTRACT FROM AUTHOR]

Published
2008
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