1. The rare sugar d-tagatose protects plants from downy mildews and is a safe fungicidal agrochemical
- Author
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Ken Izumori, Kenji Gomi, Shigeyuki Tajima, Kazuya Ichimura, Kouhei Ohtani, Keiji Tanaka, Susumu Mochizuki, Kazuya Akimitsu, Takeshi Fukumoto, Yoshio Shigematsu, Koichi Ebihara, Toshiaki Ohara, and Akihide Yoshihara
- Subjects
0106 biological sciences ,0301 basic medicine ,Medicine (miscellaneous) ,Biology ,Protective Agents ,01 natural sciences ,Fructokinase ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Environmental biotechnology ,Plant defense against herbivory ,Hexosephosphates ,Phosphorylation ,Mode of action ,lcsh:QH301-705.5 ,Mannan ,Hexoses ,Plant Diseases ,Natural product ,Fungi ,food and beverages ,Agriculture ,Rare sugar ,Fungicides, Industrial ,Fungicide ,030104 developmental biology ,chemistry ,Biochemistry ,lcsh:Biology (General) ,Downy mildew ,General Agricultural and Biological Sciences ,Agrochemicals ,010606 plant biology & botany - Abstract
The rare sugar d-tagatose is a safe natural product used as a commercial food ingredient. Here, we show that d-tagatose controls a wide range of plant diseases and focus on downy mildews to analyze its mode of action. It likely acts directly on the pathogen, rather than as a plant defense activator. Synthesis of mannan and related products of d-mannose metabolism are essential for development of fungi and oomycetes; d-tagatose inhibits the first step of mannose metabolism, the phosphorylation of d-fructose to d-fructose 6-phosphate by fructokinase, and also produces d-tagatose 6-phosphate. d-Tagatose 6-phosphate sequentially inhibits phosphomannose isomerase, causing a reduction in d-glucose 6-phosphate and d-fructose 6-phosphate, common substrates for glycolysis, and in d-mannose 6-phosphate, needed to synthesize mannan and related products. These chain-inhibitory effects on metabolic steps are significant enough to block initial infection and structural development needed for reproduction such as conidiophore and conidiospore formation of downy mildew., Mochizuki, Fukumoto, Ohara, et al. study the protective role of the rare sugar d-tagatose against plant disease. They focus on its effects against the downy mildews and delineate the metabolic pathway that blocks the initial infection. Their work paves the way for the development of safe fungicidal agrochemicals using natural products.
- Published
- 2020