1. Volatile organic compounds in plasma for the diagnosis of esophageal adenocarcinoma: a pilot study.
- Author
-
Bhatt A, Parsi MA, Stevens T, Gabbard S, Kumaravel A, Jang S, Grove D, Lopez R, Murthy S, Vargo JJ, and Dweik R
- Subjects
- Acetonitriles blood, Acrylonitrile blood, Adenocarcinoma diagnosis, Adult, Aged, Area Under Curve, Butadienes blood, Carbon Disulfide blood, Case-Control Studies, Cross-Sectional Studies, Endoscopy, Digestive System, Esophageal Neoplasms diagnosis, Ethylamines blood, Female, Gastroesophageal Reflux blood, Gastroesophageal Reflux diagnosis, Hemiterpenes blood, Hexanes blood, Humans, Hydrogen Sulfide blood, Logistic Models, Male, Middle Aged, Multivariate Analysis, Pentanes blood, Pilot Projects, Adenocarcinoma blood, Esophageal Neoplasms blood, Volatile Organic Compounds blood
- Abstract
Background and Aims: A noninvasive screening test that can detect esophageal adenocarcinoma (EAC) at an earlier stage could improve the prognosis associated with EAC. The role of plasma volatile organic compounds (VOCs) for the diagnosis of EAC has not been previously studied., Methods: Plasma samples were collected from subjects with EAC and GERD before endoscopy. Twenty-two preselected VOCs were analyzed with selected ion flow tube mass spectrometry., Results: The headspaces from 39 plasma samples (20 EAC, 19 GERD) were analyzed. The levels of 9 VOCs (acetonitrile, acrylonitrile, carbon disulfide, isoprene, 1-heptene, 3-methylhexane, [E]-2-nonene, hydrogen sulfide, and triethylamine) were significantly altered in EAC patients compared with GERD patients. A multivariable logistic regression analysis was performed to build a model for the prediction of EAC. The model identified patients with EAC with an area under the curve of 0.83 (95% confidence interval, 0.67-0.98)., Conclusions: Plasma VOCs may be useful in diagnosing EAC. Larger studies are needed to confirm our pilot study observations., (Copyright © 2016 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF