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3. Recommendation of a standardized broth microdilution method for antimicrobial susceptibility testing of Avibacterium paragallinarum and resistance monitoring

Author

Gütgemann, Franziska, primary, Heuvelink, Annet, additional, Müller, Anja, additional, Churin, Yury, additional, Buter, Rianne, additional, Jung, Arne, additional, Feberwee, Anneke, additional, Wiegel, Jeanine, additional, Kumm, Franziska, additional, Braun, Ann Sophie, additional, Yue, Min, additional, Soriano-Vargas, Edgardo, additional, Swanepoel, Stefan, additional, Botteldoorn, Nadine, additional, Kirchner, Miranda, additional, and Kehrenberg, Corinna, additional

Published
2024
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6. Molecular characterization of the HMTp210 gene of Avibacterium paragallinarum and the proposition of a new genotyping method as alternative for classical serotyping

Author

Buter, Rianne, primary, Feberwee, Anneke, additional, Wit, Sjaak de, additional, Heuvelink, Annet, additional, Silva, Ana da, additional, Gallardo, Rodrigo, additional, Vargas, Edgardo Soriano, additional, Swanepoel, Stefan, additional, Jung, Arne, additional, Tödte, Mathias, additional, and Dijkman, Remco, additional

Published
2023
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7. A Salmonella Pullorum outbreak with neurological signs in adult layers and outbreak investigation using whole genome sequencing.

Author

Molenaar, Robert Jan, Dijkman, Remco, ter Veen, Christiaan, Heuvelink, Annet, van Kaam, Fiona, Augustijn, Marieke, and Feberwee, Anneke

Subjects
WHOLE genome sequencing, SALMONELLA, SALMONELLA enterica, AGGLUTINATION tests, BONE marrow, EGGS, IMMUNOGLOBULINS
Abstract

This report describes a Salmonella enterica subspecies enterica Serovar Gallinarum Biovar Pullorum (SP) outbreak in a Dutch laying flock of 65 weeks of age (W) showing increased mortality, decreased egg production, and neurological signs. The flock was vaccinated three times with a live S. enteritis and S. typhimurium vaccine in the rearing period. At 71 W, as mortality peaked, a live SG 9R vaccine was applied. At 76 W, mortality decreased and egg production stabilized but did not return to a normal level. Post-mortem, histological, bacteriological, and serological examinations were frequently performed. Gross findings in diseased and dead birds were characterized by hepatomegaly, splenomegaly, and oophoritis. SP was frequently isolated from the liver, spleen, ovary, and bone marrow, and the isolation rate did not vary significantly between the different organs. In birds with neurological signs, histological examination and immunostaining showed cerebral granulomas in the presence of Salmonella. Previous Salmonella vaccinations did not hamper the detection of specific SP antibodies (positive at serum dilution ≥ 1:8) using a commercial rapid plate agglutination test. At 85 W, 40 clinically healthy birds were investigated and three had ovarian lesions, explaining egg production not returning to normal. These birds had antibodies against SP, indicating contact with the bacterium, but carrier status could not be confirmed by culture. Phylogenetic analysis showed SP isolates within this outbreak to be clonal and differing from SP isolates from previous outbreaks. Cerebral granulomas are associated with nervous signs in Salmonella Pullorum outbreak. Bone marrow is also a recommended tissue for isolation of Salmonella Pullorum. Rapid plate agglutination test detects Pullorum antibodies in a vaccinated flock. Phylogenetic analysis showed clonality of isolates within the outbreak. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Review and Analysis of National Monitoring Systems for Antimicrobial Resistance in Animal Bacterial Pathogens in Europe: A Basis for the Development of the European Antimicrobial Resistance Surveillance Network in Veterinary Medicine (EARS-Vet)

Author

Mader, Rodolphe, Muñoz Madero, Cristina, Aasmäe, Birgit, Bourély, Clémence, Broens, Els M, Busani, Luca, Callens, Bénédicte, Collineau, Lucie, Crespo-Robledo, Paloma, Damborg, Peter, Filippitzi, Maria-Eleni, Fitzgerald, William, Heuvelink, Annet, van Hout, Jobke, Kaspar, Heike, Norström, Madelaine, Pedersen, Karl, Pohjanvirta, Tarja, Pokludova, Lucie, Dal Pozzo, Fabiana, Slowey, Rosemarie, Teixeira Justo, Cristiana, Urdahl, Anne Margrete, Vatopoulos, Alkiviadis, Zafeiridis, Christos, Madec, Jean-Yves, Amat, Jean-Philippe, Klinische infectiologie en microb. lab., dI&I I&I-4, Klinische infectiologie en microb. lab., and dI&I I&I-4

Subjects
Microbiology (medical), Europe, monitoring, antimicrobial resistance (AMR), antibiotic, surveillance, animal, Antimicrobial resistance, antibiotic, surveillance, animal pathogens, veterinay medicine, veterinary, Microbiology, pathogen
Abstract

The monitoring of antimicrobial resistance (AMR) in bacterial pathogens of animals is not currently coordinated at European level. To fill this gap, experts of the European Union Joint Action on Antimicrobial Resistance and Healthcare Associated Infections (EU-JAMRAI) recommended building the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet). In this study, we (i) identified national monitoring systems for AMR in bacterial pathogens of animals (both companion and food-producing) among 27 countries affiliated to EU-JAMRAI, (ii) described their structures and operations, and (iii) analyzed their respective strengths, weaknesses, opportunities and threats (SWOT). Twelve countries reported having at least one national monitoring system in place, representing an opportunity to launch EARS-Vet, but highlighting important gaps in AMR data generation in Europe. In total, 15 national monitoring systems from 11 countries were described and analyzed. They displayed diverse structures and operations, but most of them shared common weaknesses (e.g., data management and representativeness) and common threats (e.g., economic vulnerability and data access), which could be addressed collectively under EARS-Vet. This work generated useful information to countries planning to build or improve their system, by learning from others’ experience. It also enabled to advance on a pragmatic harmonization strategy: EARS-Vet shall follow the European Committee on Antimicrobial Susceptibility Testing (EUCAST) standards, collect quantitative data and interpret AMR data using epidemiological cut-off values.

Published
2022
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14. Review and Analysis of National Monitoring Systems for Antimicrobial Resistance in Animal Bacterial Pathogens in Europe: A Basis for the Development of the European Antimicrobial Resistance Surveillance Network in Veterinary Medicine (EARS-Vet)

Author

Klinische infectiologie en microb. lab., dI&I I&I-4, Mader, Rodolphe, Muñoz Madero, Cristina, Aasmäe, Birgit, Bourély, Clémence, Broens, Els M, Busani, Luca, Callens, Bénédicte, Collineau, Lucie, Crespo-Robledo, Paloma, Damborg, Peter, Filippitzi, Maria-Eleni, Fitzgerald, William, Heuvelink, Annet, van Hout, Jobke, Kaspar, Heike, Norström, Madelaine, Pedersen, Karl, Pohjanvirta, Tarja, Pokludova, Lucie, Dal Pozzo, Fabiana, Slowey, Rosemarie, Teixeira Justo, Cristiana, Urdahl, Anne Margrete, Vatopoulos, Alkiviadis, Zafeiridis, Christos, Madec, Jean-Yves, Amat, Jean-Philippe, Klinische infectiologie en microb. lab., dI&I I&I-4, Mader, Rodolphe, Muñoz Madero, Cristina, Aasmäe, Birgit, Bourély, Clémence, Broens, Els M, Busani, Luca, Callens, Bénédicte, Collineau, Lucie, Crespo-Robledo, Paloma, Damborg, Peter, Filippitzi, Maria-Eleni, Fitzgerald, William, Heuvelink, Annet, van Hout, Jobke, Kaspar, Heike, Norström, Madelaine, Pedersen, Karl, Pohjanvirta, Tarja, Pokludova, Lucie, Dal Pozzo, Fabiana, Slowey, Rosemarie, Teixeira Justo, Cristiana, Urdahl, Anne Margrete, Vatopoulos, Alkiviadis, Zafeiridis, Christos, Madec, Jean-Yves, and Amat, Jean-Philippe

Published
2022

15. Antimicrobial resistance monitoring in commensal and clinical Escherichia coli from broiler chickens: Differences and similarities

Author

FAH Evidence based Veterinary Medicine, dFAH AVR, Klinische infectiologie en microb. lab., dI&I I&I-4, Hesp, Ayla, van Schaik, Gerdien, Wiegel, Jeanine, Heuvelink, Annet, Mevius, Dik, Veldman, Kees, FAH Evidence based Veterinary Medicine, dFAH AVR, Klinische infectiologie en microb. lab., dI&I I&I-4, Hesp, Ayla, van Schaik, Gerdien, Wiegel, Jeanine, Heuvelink, Annet, Mevius, Dik, and Veldman, Kees

Published
2022

16. Review and Analysis of National Monitoring Systems for Antimicrobial Resistance in Animal Bacterial Pathogens in Europe:A Basis for the Development of the European Antimicrobial Resistance Surveillance Network in Veterinary Medicine (EARS-Vet)

Author

Mader, Rodolphe, Muñoz Madero, Cristina, Aasmäe, Birgit, Bourély, Clémence, Broens, Els M., Busani, Luca, Callens, Bénédicte, Collineau, Lucie, Crespo-Robledo, Paloma, Damborg, Peter, Filippitzi, Maria Eleni, Fitzgerald, William, Heuvelink, Annet, van Hout, Jobke, Kaspar, Heike, Norström, Madelaine, Pedersen, Karl, Pohjanvirta, Tarja, Pokludova, Lucie, Dal Pozzo, Fabiana, Slowey, Rosemarie, Teixeira Justo, Cristiana, Urdahl, Anne Margrete, Vatopoulos, Alkiviadis, Zafeiridis, Christos, Madec, Jean Yves, Amat, Jean Philippe, Mader, Rodolphe, Muñoz Madero, Cristina, Aasmäe, Birgit, Bourély, Clémence, Broens, Els M., Busani, Luca, Callens, Bénédicte, Collineau, Lucie, Crespo-Robledo, Paloma, Damborg, Peter, Filippitzi, Maria Eleni, Fitzgerald, William, Heuvelink, Annet, van Hout, Jobke, Kaspar, Heike, Norström, Madelaine, Pedersen, Karl, Pohjanvirta, Tarja, Pokludova, Lucie, Dal Pozzo, Fabiana, Slowey, Rosemarie, Teixeira Justo, Cristiana, Urdahl, Anne Margrete, Vatopoulos, Alkiviadis, Zafeiridis, Christos, Madec, Jean Yves, and Amat, Jean Philippe

Abstract

The monitoring of antimicrobial resistance (AMR) in bacterial pathogens of animals is not currently coordinated at European level. To fill this gap, experts of the European Union Joint Action on Antimicrobial Resistance and Healthcare Associated Infections (EU-JAMRAI) recommended building the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet). In this study, we (i) identified national monitoring systems for AMR in bacterial pathogens of animals (both companion and food-producing) among 27 countries affiliated to EU-JAMRAI, (ii) described their structures and operations, and (iii) analyzed their respective strengths, weaknesses, opportunities and threats (SWOT). Twelve countries reported having at least one national monitoring system in place, representing an opportunity to launch EARS-Vet, but highlighting important gaps in AMR data generation in Europe. In total, 15 national monitoring systems from 11 countries were described and analyzed. They displayed diverse structures and operations, but most of them shared common weaknesses (e.g., data management and representativeness) and common threats (e.g., economic vulnerability and data access), which could be addressed collectively under EARS-Vet. This work generated useful information to countries planning to build or improve their system, by learning from others’ experience. It also enabled to advance on a pragmatic harmonization strategy: EARS-Vet shall follow the European Committee on Antimicrobial Susceptibility Testing (EUCAST) standards, collect quantitative data and interpret AMR data using epidemiological cut-off values.

Published
2022

18. Identification, HPG2 sequence analysis and antimicrobial susceptibility of Avibacterium paragallinarum isolates obtained from outbreaks of infectious coryza in commercial chickens in Sonora State, Mexico

Author

Luna-Castrejon, L, Buter, R., Pantoja, G, Acuna, M, Heuvelink, Annet, de Wit, Sjaak, Soriano-Vargas, Edgardo, Feberwee, A, and FAH veterinaire epidemiologie

Abstract

This is the first extensive report on the identification and characterization of Avibacterium paragallinarum (AVP) isolates obtained from outbreaks of infectious coryza (IC) in IC-vaccinated layer flocks from Sonora State in Mexico. Isolates obtained from IC outbreaks during the years 2007, 2014, 2015, 2017, and 2019 were identified by conventional PCR test and 16S rRNA gene analysis, serotyped by Page serotyping and genotyped by the recently described partial sequence analysis of the HPG2 region. Furthermore, antimicrobial susceptibility profiles were determined by a recently improved minimal inhibitory concentration (MIC) test. The conventional PCR test and the 16S rRNA analyses confirmed the isolates as AVP. Serotyping results showed the involvement of isolates belonging to serotypes A, B, and C in the IC outbreaks. Genotyping of the HPG2 region revealed the presence of sequence type (ST)1, ST4, and ST11, of which the latter has also been identified in Europe. The MIC susceptibility test showed that all tested isolates were susceptible for the majority of tested antimicrobials, including erythromycin and tetracycline, which are important antibiotics for the treatment of IC. The IC situation in Sonora State, Mexico, is complex because of the presence of serotypes A, B, and C. This finding emphasizes the importance of biosecurity in combination with the application of the most optimal vaccination programs in the control of IC in Sonora State, Mexico.

Published
2021

19. Identification, HPG2 sequence analysis and antimicrobial susceptibility of Avibacterium paragallinarum isolates obtained from outbreaks of infectious coryza in commercial chickens in Sonora State, Mexico

Author

FAH veterinaire epidemiologie, Luna-Castrejon, L, Buter, R., Pantoja, G, Acuna, M, Heuvelink, Annet, de Wit, Sjaak, Soriano-Vargas, Edgardo, Feberwee, A, FAH veterinaire epidemiologie, Luna-Castrejon, L, Buter, R., Pantoja, G, Acuna, M, Heuvelink, Annet, de Wit, Sjaak, Soriano-Vargas, Edgardo, and Feberwee, A

Published
2021

20. White Paper: Bridging the gap between surveillance data and antimicrobial stewardship in the animal sector-practical guidance from the JPIAMR ARCH and COMBACTE-MAGNET EPI-Net networks

Author

Compri, Monica, Mader, Rodolphe, Mazzolini, Elena, de Angelis, Giulia, Mutters, Nico T, Babu Rajendran, Nithya, Galia, Liliana, Tacconelli, Evelina, Schrijver, Remco, Adegnika, Ayola Akim, Arieti, Fabiana, Rajendran, Nithya Babu, Bielicki, Julia, Borrmann, Steffen, Carrara, Elena, Cauda, Roberto, De Angelis, Giulia, Filippitzi, Maria-Eleni, Frost, Isabel, Giske, Christian, Göpel, Siri, Guardabassi, Luca, Heuvelink, Annet, Kahlmeter, Gunnar, Kanj, Souha S, Kostyanev, Tomislav, Leibovici, Leonard, Lucet, Jean-Christophe, López-Cerero, Lorena, Mazzaferri, Fulvia, Mendelson, Marc, Murri, Rita, Paul, Mical, Pezzani, Maria Diletta, Presterl, Elisabeth, Renk, Hanna, Song, Le Huu, Sanguinetti, Maurizio, Scudeller, Luigia, Sharland, Mike, Sibani, Marcella, Torumkuney, Didem, Velavan, Thirumalaisamy P, and Voss, Andreas

Subjects
Pharmacology, Microbiology (medical), 0303 health sciences, Infection Control, 030306 microbiology, 040301 veterinary sciences, ANTIBIOTIC-RESISTANCE, 04 agricultural and veterinary sciences, Anti-Bacterial Agents, 0403 veterinary science, 03 medical and health sciences, Antimicrobial Stewardship, Infectious Diseases, AcademicSubjects/MED00290, Anti-Infective Agents, ESCHERICHIA-COLI, Supplement Papers, Magnets, HEALTHMETRICS, Animals, AcademicSubjects/MED00740, Pharmacology (medical), ANTIBIOTIC-RESISTANCE,ESCHERICHIA-COLI,HEALTHMETRICS, AcademicSubjects/MED00230
Abstract

BackgroundThe JPIAMR ARCH and COMBACTE-MAGNET EPI-Net networks have joined efforts to formulate a set of target actions to link the surveillance of antimicrobial usage (AMU) and antimicrobial resistance (AMR) with antimicrobial stewardship (AMS) activities in four different settings. This White Paper focuses on the veterinary setting and embraces the One Health approach.MethodsA review of the literature was carried out addressing research questions in three areas: AMS leadership and accountability; AMU surveillance and AMS; and AMR surveillance and AMS. Consensus on target actions was reached through a RAND-modified Delphi process involving over 40 experts in infectious diseases, clinical microbiology, AMS, veterinary medicine and public health, from 18 countries.Results/discussionForty-six target actions were developed and qualified as essential or desirable. Essential actions included the setup of AMS teams in all veterinary settings, building government-supported AMS programmes and following specific requirements on the production, collection and communication of AMU and AMR data. Activities of AMS teams should be tailored to the local situation and capacities, and be linked to local or national surveillance systems and infection control programmes. Several research priorities were also identified, such as the need to develop more clinical breakpoints in veterinary medicine.ConclusionsThis White Paper offers a practical tool to veterinary practitioners and policy makers to improve AMS in the One Health approach, thanks to surveillance data generated in the veterinary setting. This work may also be useful to medical doctors wishing to better understand the specificities of the veterinary setting and facilitate cross-sectoral collaborations.

Published
2020
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22. Development and evaluation of 4 loop-mediated isothermal amplification assays to detect mastitis-causing bacteria in bovine milk samples

Author

Griffioen, Karien, Cornelissen, Jan, Heuvelink, Annet, Adusei, Daniela, Mevius, Dik, Jan van der Wal, Fimme, Griffioen, Karien, Cornelissen, Jan, Heuvelink, Annet, Adusei, Daniela, Mevius, Dik, and Jan van der Wal, Fimme

Abstract

Farmers prefer fast, sensitive, and on-site tests for treatment decisions on mastitis. Due to the time to results of the currently available diagnostic tools, these are rarely used for that purpose. Genotypic tests that do not require a growth step may be suitable for on-site testing, for example loop-mediated isothermal amplification (LAMP), which has been described as a sensitive test that can be used on-site. Therefore, this study aimed to develop and evaluate LAMP assays for the detection of a subset of mastitis-causing pathogens, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Streptococcus spp., in milk from cows with clinical mastitis. Furthermore, a generic nucleic acid lateral flow immunoassay (NALFIA) was evaluated as a potential on-site readout of the LAMP assays. For each assay of LAMP and NALFIA, the limit of detection and analytical specificity were determined using isolates, and the diagnostic specificity was determined using selected samples with known etiology. In addition, the diagnostic specificity of LAMP was determined using field samples with unknown etiology at testing. Bacteriological culture with identification by mass spectrometry was used as a reference method. The 4 assays had a kappa ≥0.73 with the reference method when testing the selected samples, but ≥0.47 when testing field samples. After correcting for prevalence, kappa was ≥0.80 for the E. coli, K. pneumoniae, and Staph. aureus assays. The Streptococcus spp. assay had a kappa of 0.47 (0.48 after correction) with the reference method, probably caused by the assay broadly targeting a genus instead of a particular species. The NALFIA readout was found to have kappa ≥0.81 for the E. coli, Staph. aureus, and Streptococcus spp. assays at a generic runtime, but for the K. pneumoniae assay a shorter runtime could be used. In conclusion, LAMP is a promising method for fast on-site tests for mastitis-causing pathogens if the current elaborate method for sample preparation

Published
2020

23. Development and evaluation of 4 loop-mediated isothermal amplification assays to detect mastitis-causing bacteria in bovine milk samples

Author

dFAH AVR, Klinische infectiologie en microb. lab., dI&I I&I-4, Griffioen, Karien, Cornelissen, Jan, Heuvelink, Annet, Adusei, Daniela, Mevius, Dik, Jan van der Wal, Fimme, dFAH AVR, Klinische infectiologie en microb. lab., dI&I I&I-4, Griffioen, Karien, Cornelissen, Jan, Heuvelink, Annet, Adusei, Daniela, Mevius, Dik, and Jan van der Wal, Fimme

Published
2020

24. Antimicrobial use in dairy cattle in the Netherlands

Author

FAH veterinaire epidemiologie, dFAH AVR, FAH Evidence based Veterinary Medicine, Lam, Theo J G M, Heuvelink, Annet E, Gonggrijp, Maaike A, Santman-Berends, Inge M G A, FAH veterinaire epidemiologie, dFAH AVR, FAH Evidence based Veterinary Medicine, Lam, Theo J G M, Heuvelink, Annet E, Gonggrijp, Maaike A, and Santman-Berends, Inge M G A

Published
2020

25. Molecular relatedness of ESBL/AmpC-producing Escherichia coli from humans, animals, food and the enviroment : a pooled analysis

Author

Dorado-García, Alejandro, Smid, Joost H, van Pelt, Wilfrid, Bonten, Marc J M, Fluit, Ad C, van den Bunt, Gerrita, Wagenaar, Jaap A, Hordijk, Joost, Dierikx, Cindy M, Veldman, Kees T, de Koeijer, Aline, Dohmen, Wietske, Schmitt, Heike, Liakopoulos, Apostolos, Pacholewicz, Ewa, Lam, Theo J G M, Velthuis, Annet G J, Heuvelink, Annet, Gonggrijp, Maaike A, van Duijkeren, Engeline, van Hoek, Angela H A M, de Roda Husman, Ana Maria, Blaak, Hetty, Havelaar, Arie H, Mevius, Dik J, Heederik, Dick J J, LS Klinisch Onderzoek Wagenaar, LS GZ Landbouwhuisdieren, dIRAS RA-I&I RA, One Health Microbieel, Sub Algemeen Artificial Intelligence, dI&I I&I-4, dIRAS RA-I&I I&I, Sub RIVM, Dep IRAS, Dep Infectieziekten Immunologie, LS IRAS VPH MBR (microbiol.risico sch.), LS Klinisch Onderzoek Wagenaar, LS GZ Landbouwhuisdieren, dIRAS RA-I&I RA, One Health Microbieel, Sub Algemeen Artificial Intelligence, dI&I I&I-4, dIRAS RA-I&I I&I, Sub RIVM, Dep IRAS, Dep Infectieziekten Immunologie, and LS IRAS VPH MBR (microbiol.risico sch.)

Subjects
0301 basic medicine, Swine, Epidemiology, extended-spectrum beta-lactamases, medicine.disease_cause, Poultry, Plasmid, Environmental Microbiology, polycyclic compounds, Pharmacology (medical), Replicon, Escherichia coli Infections, Netherlands, Genetics, education.field_of_study, Infectious Diseases, Pooled analysis, Livestock, escherichia coli, farm animals, Microbiology (medical), plasmids, Bioinformatica & Diermodellen, 030106 microbiology, Population, Coronacrisis-Taverne, Biology, beta-Lactamases, Birds, 03 medical and health sciences, Bio-informatics & Animal models, medicine, Disease Transmission, Infectious, Life Science, Animals, Humans, Epidemiology, Bio-informatics & Animal models, education, Escherichia coli, Pharmacology, Epidemiologie, business.industry, food, Genetic Variation, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Carriage, Epidemiologie, Bioinformatica & Diermodellen, Food Microbiology, WIAS, bacteria, business, Food contaminant, replicon
Abstract

Background: In recent years, ESBL/AmpC-producing Escherichia coli (ESBL/AmpC-EC) have been isolated with increasing frequency from animals, food, environmental sources and humans. With incomplete and scattered evidence, the contribution to the human carriage burden from these reservoirs remains unclear. Objectives: To quantify molecular similarities between different reservoirs as a first step towards risk attribution. Methods: Pooled data on ESBL/AmpC-EC isolates were recovered from 35 studies in the Netherlands comprising >27 000 samples, mostly obtained between 2005 and 2015. Frequency distributions of ESBL/AmpC genes from 5808 isolates and replicons of ESBL/AmpC-carrying plasmids from 812 isolates were compared across 22 reservoirs through proportional similarity indices (PSIs) and principal component analyses (PCAs). Results: Predominant ESBL/AmpC genes were identified in each reservoir. PCAs and PSIs revealed close human-animal ESBL/AmpC gene similarity between human farming communities and their animals (broilers and pigs) (PSIs from 0.8 to 0.9). Isolates from people in the general population had higher similarities to those from human clinical settings, surface and sewage water and wild birds (0.7-0.8), while similarities to livestock or food reservoirs were lower (0.3-0.6). Based on rarefaction curves, people in the general population had more diversity in ESBL/AmpC genes and plasmid replicon types than those in other reservoirs. Conclusions: Our 'One Health' approach provides an integrated evaluation of the molecular relatedness of ESBL/AmpC-EC from numerous sources. The analysis showed distinguishable ESBL/AmpC-EC transmission cycles in different hosts and failed to demonstrate a close epidemiological linkage of ESBL/AmpC genes and plasmid replicon types between livestock farms and people in the general population.

Published
2018
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26. Defining the scope of the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet): a bottom-up and One Health approach

Author

Mader, Rodolphe, primary, Bourély, Clémence, additional, Amat, Jean-Philippe, additional, Broens, Els M., additional, Busani, Luca, additional, Callens, Bénédicte, additional, Crespo, Paloma, additional, Damborg, Peter, additional, Filippitzi, Maria-Eleni, additional, Fitzgerald, William, additional, Grönthal, Thomas, additional, Haenni, Marisa, additional, Heuvelink, Annet, additional, van Hout, Jobke, additional, Kaspar, Heike, additional, Munoz, Cristina, additional, Norström, Madelaine, additional, Pedersen, Karl, additional, Pokludova, Lucie, additional, Pozzo, Fabiana Dal, additional, Slowey, Rosemarie, additional, Urdahl, Anne Margrete, additional, Vatopoulos, Alkiviadis, additional, Zafeiridis, Christos, additional, and Madec, Jean-Yves, additional

Published
2021
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28. Identification, HPG2 Sequence Analysis, and Antimicrobial Susceptibility of Avibacterium paragallinarum Isolates Obtained from Outbreaks of Infectious Coryza in Commercial Layers in Sonora State, Mexico

Author

Luna-Castrejón, Linda Patricia, primary, Buter, Rianne, additional, Pantoja-Nuñez, Gabriel Iván, additional, Acuña-Yanes, Martín, additional, Ceballos-Valenzuela, Karla, additional, Talavera-Rojas, Martín, additional, Salgado-Miranda, Celene, additional, Heuvelink, Annet, additional, de Wit, Sjaak, additional, Soriano-Vargas, Edgardo, additional, and Feberwee, Anneke, additional

Published
2020
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31. Defining the scope of the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet): a bottom-up and One Health approach.

Author

Mader, Rodolphe, EU-JAMRAI, Bourély, Clémence, Amat, Jean-Philippe, Broens, Els M, Busani, Luca, Callens, Bénédicte, Crespo-Robledo, Paloma, Damborg, Peter, Filippitzi, Maria-Eleni, Fitzgerald, William, Grönthal, Thomas, Haenni, Marisa, Heuvelink, Annet, Hout, Jobke van, Kaspar, Heike, Madero, Cristina Muñoz, Norström, Madelaine, Pedersen, Karl, and Pokludova, Lucie

Subjects
DRUG resistance in microorganisms, ACTINOBACILLUS pleuropneumoniae, STREPTOCOCCUS suis, MANNHEIMIA haemolytica, PASTEURELLA multocida, STREPTOCOCCUS pneumoniae, TURKEYS, VETERINARY medicine, CATTLE, POULTRY, ANIMAL experimentation, CATS, SWINE, RESEARCH funding, DOGS
Abstract

Background: Building the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet) was proposed to strengthen the European One Health antimicrobial resistance (AMR) surveillance approach.Objectives: To define the combinations of animal species/production types/age categories/bacterial species/specimens/antimicrobials to be monitored in EARS-Vet.Methods: The EARS-Vet scope was defined by consensus between 26 European experts. Decisions were guided by a survey of the combinations that are relevant and feasible to monitor in diseased animals in 13 European countries (bottom-up approach). Experts also considered the One Health approach and the need for EARS-Vet to complement existing European AMR monitoring systems coordinated by the ECDC and the European Food Safety Authority (EFSA).Results: EARS-Vet plans to monitor AMR in six animal species [cattle, swine, chickens (broilers and laying hens), turkeys, cats and dogs], for 11 bacterial species (Escherichia coli, Klebsiella pneumoniae, Mannheimia haemolytica, Pasteurella multocida, Actinobacillus pleuropneumoniae, Staphylococcus aureus, Staphylococcus pseudintermedius, Staphylococcus hyicus, Streptococcus uberis, Streptococcus dysgalactiae and Streptococcus suis). Relevant antimicrobials for their treatment were selected (e.g. tetracyclines) and complemented with antimicrobials of more specific public health interest (e.g. carbapenems). Molecular data detecting the presence of ESBLs, AmpC cephalosporinases and methicillin resistance shall be collected too.Conclusions: A preliminary EARS-Vet scope was defined, with the potential to fill important AMR monitoring gaps in the animal sector in Europe. It should be reviewed and expanded as the epidemiology of AMR changes, more countries participate and national monitoring capacities improve. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Identification and characterization of Dutch Avibacterium paragallinarum isolates and the implications for diagnostics

Author

Feberwee, Anneke, Dijkman, Remco, Buter, Rianne, Soriano-Vargas, Edgardo, Morales-Erasto, Vladimir, Heuvelink, Annet, Fabri, Teun, Bouwstra, Ruth, de Wit, Sjaak, and FAH veterinaire epidemiologie

Subjects
Serotype, food.ingredient, 040301 veterinary sciences, Sequence analysis, Avibacterium paragallinarum, Virulence, Biology, Avibacterium, Microbiology, law.invention, 0403 veterinary science, Intergenic region, food, Food Animals, law, Genotype, Genotyping, Polymerase chain reaction, General Immunology and Microbiology, 0402 animal and dairy science, 04 agricultural and veterinary sciences, 040201 dairy & animal science, serotyping, virulence, genotyping, Diagnostic tests, Animal Science and Zoology, Dutch
Abstract

This study reports the results of diagnostic and molecular typing methods for 18 Avibacterium paragallinarum isolates obtained from outbreaks of infectious coryza in commercial layer flocks in the Netherlands. Isolation, biochemical identification, species-specific PCR tests and classical serotyping were performed. In addition, molecular typing by Enterobacterial Repetitive Intergenic Consensus-Based Polymerase Chain Reaction (ERIC-PCR) and sequence analysis of the partial HPG2 region of A. paragallinarum were applied and results of both techniques were compared. Moreover, the pathogenicity of an isolate of the most common genotype detected in the Netherlands was determined in an animal experiment. All 18 Avibacterium isolates were nicotinamide adenine dinucleotide-dependent. All isolates were detected by the species-specific conventional PCR while 33% of the isolates were missed by the species-specific real-time PCR. Sequence analysis showed a probe mismatch as a result of a single nucleotide polymorphism (G1516A). Modification of the probe of the real-time PCR was necessary to overcome false negative results. Molecular typing showed that sequence analysis of the partial HPG2 region was in concordance with ERIC-PCR results and indicated the presence of two major genotypes. Serotyping showed the presence of serovars A-1, A-2 and B-1. There was no correlation between genotyping results and serotyping results. Inoculation of an isolate of the most prevalent genotype, and belonging to serovar A-1, into brown layer hens demonstrated the pathogenicity of this isolate.

Published
2019

34. Antimicrobial use in dairy cattle in the Netherlands

Author

Lam, Theo J G M, Heuvelink, Annet E, Gonggrijp, Maaike A, Santman-Berends, Inge M G A, FAH veterinaire epidemiologie, dFAH AVR, and FAH Evidence based Veterinary Medicine

Subjects
Veterinary medicine, Antimicrobial use, Genetics, Animal Science and Zoology, Perspectives of Antimicrobial Use in Livestock Production, General Medicine, Biology, Dairy cattle, Food Science
Published
2019

35. Diagnostiek Ontwikkeling en Toepassing voor het optimaliseren van uiergezondheid

Author

Griffioen, Karien, Velthuis, A.G.J., van der Wal, F.J., Mevius, D.J., Achterberg, R.P., Cornelissen, J.B.W.J., Dijkman, Remco, Heuvelink, Annet E., Hop, G.E., Holstege, Manon M.C., Scherpenzeel, Christian, and Lam, Theo

Subjects
Epidemiologie, Bioinformatica & Diermodellen, Bacteriologie, Host Pathogen Interactie & Diagnostiek, Life Science, Epidemiology, Bio-informatics & Animal models, Bacteriology, Host Pathogen Interaction & Diagnostics
Published
2019

38. Identification and characterization of Dutch Avibacterium paragallinarum isolates and the implications for diagnostics

Author

FAH veterinaire epidemiologie, Feberwee, Anneke, Dijkman, Remco, Buter, Rianne, Soriano-Vargas, Edgardo, Morales-Erasto, Vladimir, Heuvelink, Annet, Fabri, Teun, Bouwstra, Ruth, de Wit, Sjaak, FAH veterinaire epidemiologie, Feberwee, Anneke, Dijkman, Remco, Buter, Rianne, Soriano-Vargas, Edgardo, Morales-Erasto, Vladimir, Heuvelink, Annet, Fabri, Teun, Bouwstra, Ruth, and de Wit, Sjaak

Published
2019

39. Samenvatting ESBL-Attributieanalyse (ESBLAT) : Op zoek naar de bronnen van antibioticaresistentie bij de mens

Author

Mevius, Dik, Heederik, Dick, Duijkeren, Engeline, Veldman, Kees, van Essen, Alieda, Kant, Arie, Liakopoulos, Apostolos, Geurts, Yvon, van Pelt, Wilfrid, Mughini Gras, Lapo, Schmitt, Heike, Dierikx, Cindy, van Hoek, Angela, Evers, Eric, de Roda Husman, Annemaria, Blaak, Hetty, van Dissel, Jaap, Smid, Joost, Dohmen, Wietske, Dorado-Garcia, Alejandro, Havelaar, Arie, Hordijk, Joost, Wagenaar, Jaap, Fluit, Ad, van den Bunt, Gerrita, Bonten, Marc, Velthuis, Annet, Heuvelink, Annet, Buter, Rianne, Gonggrijp, Maaike, Santman-Berends, Inge, Lam, Theo, Urlings, Bert, Heres, Lourens, Bouwknecht, Martijn, and de Groot, Jacques

Subjects
Epidemiologie, Bioinformatica & Diermodellen, Life Science, Epidemiology, Bio-informatics & Animal models
Published
2018

40. Rapport ESBL-Attributieanalyse (ESBLAT) : Op zoek naar de bronnen van antibioticaresistentie bij de mens

Author

Mevius, Dik, Heederik, Dick, Duijkeren, Engeline, Veldman, Kees, van Essen, Alieda, Kant, Arie, Liakopoulos, Apostolos, Geurts, Yvon, van Pelt, Wilfrid, Mughini Gras, Lapo, Schmitt, Heike, Dierikx, Cindy, van Hoek, Angela, Evers, Eric, de Roda Husman, Annemaria, Blaak, Hetty, van Dissel, Jaap, Smid, Joost, Dohmen, Wietske, Dorado-Garcia, Alejandro, Havelaar, Arie, Hordijk, Joost, Wagenaar, Jaap, Fluit, Ad, van den Bunt, Gerrita, Bonten, Marc, Velthuis, Annet, Heuvelink, Annet, Buter, Rianne, Gonggrijp, Maaike, Santman-Berends, Inge, Lam, Theo, Urlings, Bert, Heres, Lourens, Bouwknecht, Martijn, and de Groot, Jacques

Subjects
Epidemiologie, Bioinformatica & Diermodellen, Life Science, Epidemiology, Bio-informatics & Animal models
Published
2018

44. Molecular relatedness of ESBL/AmpC-producing Escherichia coli from humans, animals, food and the environment: a pooled analysis

Author

LS Klinisch Onderzoek Wagenaar, LS GZ Landbouwhuisdieren, dIRAS RA-I&I RA, One Health Microbieel, Sub Algemeen Artificial Intelligence, dI&I I&I-4, dIRAS RA-I&I I&I, Sub RIVM, Dep IRAS, Dep Infectieziekten Immunologie, LS IRAS VPH MBR (microbiol.risico sch.), Dorado-García, Alejandro, Smid, Joost H, van Pelt, Wilfrid, Bonten, Marc J M, Fluit, Ad C, van den Bunt, Gerrita, Wagenaar, Jaap A, Hordijk, Joost, Dierikx, Cindy M, Veldman, Kees T, de Koeijer, Aline, Dohmen, Wietske, Schmitt, Heike, Liakopoulos, Apostolos, Pacholewicz, Ewa, Lam, Theo J G M, Velthuis, Annet G J, Heuvelink, Annet, Gonggrijp, Maaike A, van Duijkeren, Engeline, van Hoek, Angela H A M, de Roda Husman, Ana Maria, Blaak, Hetty, Havelaar, Arie H, Mevius, Dik J, Heederik, Dick J J, LS Klinisch Onderzoek Wagenaar, LS GZ Landbouwhuisdieren, dIRAS RA-I&I RA, One Health Microbieel, Sub Algemeen Artificial Intelligence, dI&I I&I-4, dIRAS RA-I&I I&I, Sub RIVM, Dep IRAS, Dep Infectieziekten Immunologie, LS IRAS VPH MBR (microbiol.risico sch.), Dorado-García, Alejandro, Smid, Joost H, van Pelt, Wilfrid, Bonten, Marc J M, Fluit, Ad C, van den Bunt, Gerrita, Wagenaar, Jaap A, Hordijk, Joost, Dierikx, Cindy M, Veldman, Kees T, de Koeijer, Aline, Dohmen, Wietske, Schmitt, Heike, Liakopoulos, Apostolos, Pacholewicz, Ewa, Lam, Theo J G M, Velthuis, Annet G J, Heuvelink, Annet, Gonggrijp, Maaike A, van Duijkeren, Engeline, van Hoek, Angela H A M, de Roda Husman, Ana Maria, Blaak, Hetty, Havelaar, Arie H, Mevius, Dik J, and Heederik, Dick J J

Published
2018

45. Molecular relatedness of ESBL/AmpC-producing Escherichia coli from humans, animals, food and the environment: a pooled analysis

Author

Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, Dorado-García, Alejandro, Smid, Joost H, van Pelt, Wilfrid, Bonten, Marc J M, Fluit, Ad C., van den Bunt, Gerrita, Wagenaar, Jaap A., Hordijk, Joost, Dierikx, Cindy M, Veldman, Kees T, de Koeijer, Aline A., Dohmen, Wietske, Schmitt, Heike, Liakopoulos, Apostolos, Pacholewicz, Ewa, Lam, Theo J G M, Velthuis, Annet G, Heuvelink, Annet, Gonggrijp, Maaike A, van Duijkeren, Engeline, van Hoek, Angela H A M, de Roda Husman, Ana Maria, Blaak, Hetty, Havelaar, Arie H., Mevius, Dik J, Heederik, Dick J J, Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, Dorado-García, Alejandro, Smid, Joost H, van Pelt, Wilfrid, Bonten, Marc J M, Fluit, Ad C., van den Bunt, Gerrita, Wagenaar, Jaap A., Hordijk, Joost, Dierikx, Cindy M, Veldman, Kees T, de Koeijer, Aline A., Dohmen, Wietske, Schmitt, Heike, Liakopoulos, Apostolos, Pacholewicz, Ewa, Lam, Theo J G M, Velthuis, Annet G, Heuvelink, Annet, Gonggrijp, Maaike A, van Duijkeren, Engeline, van Hoek, Angela H A M, de Roda Husman, Ana Maria, Blaak, Hetty, Havelaar, Arie H., Mevius, Dik J, and Heederik, Dick J J

Published
2018

46. Molecular relatedness of ESBL/AmpC-producing Escherichia coli from humans, animals, food and the environment: a pooled analysis

Author

One Health Microbieel, Sub Algemeen Artificial Intelligence, LS Klinisch Onderzoek Wagenaar, dI&I I&I-4, Dep Infectieziekten Immunologie, dIRAS RA-I&I I&I, LS IRAS VPH MBR (microbiol.risico sch.), LS GZ Landbouwhuisdieren, dIRAS RA-I&I RA, Sub RIVM, Dep IRAS, Dorado-García, Alejandro, Smid, Joost H, van Pelt, Wilfrid, Bonten, Marc J M, Fluit, Ad C, van den Bunt, Gerrita, Wagenaar, Jaap A, Hordijk, Joost, Dierikx, Cindy M, Veldman, Kees T, de Koeijer, Aline, Dohmen, Wietske, Schmitt, Heike, Liakopoulos, Apostolos, Pacholewicz, Ewa, Lam, Theo J G M, Velthuis, Annet G J, Heuvelink, Annet, Gonggrijp, Maaike A, van Duijkeren, Engeline, van Hoek, Angela H A M, de Roda Husman, Ana Maria, Blaak, Hetty, Havelaar, Arie H, Mevius, Dik J, Heederik, Dick J J, One Health Microbieel, Sub Algemeen Artificial Intelligence, LS Klinisch Onderzoek Wagenaar, dI&I I&I-4, Dep Infectieziekten Immunologie, dIRAS RA-I&I I&I, LS IRAS VPH MBR (microbiol.risico sch.), LS GZ Landbouwhuisdieren, dIRAS RA-I&I RA, Sub RIVM, Dep IRAS, Dorado-García, Alejandro, Smid, Joost H, van Pelt, Wilfrid, Bonten, Marc J M, Fluit, Ad C, van den Bunt, Gerrita, Wagenaar, Jaap A, Hordijk, Joost, Dierikx, Cindy M, Veldman, Kees T, de Koeijer, Aline, Dohmen, Wietske, Schmitt, Heike, Liakopoulos, Apostolos, Pacholewicz, Ewa, Lam, Theo J G M, Velthuis, Annet G J, Heuvelink, Annet, Gonggrijp, Maaike A, van Duijkeren, Engeline, van Hoek, Angela H A M, de Roda Husman, Ana Maria, Blaak, Hetty, Havelaar, Arie H, Mevius, Dik J, and Heederik, Dick J J

Published
2018

47. Identification, HPG2 Sequence Analysis, and Antimicrobial Susceptibility of Avibacterium paragallinarum Isolates Obtained from Outbreaks of Infectious Coryza in Commercial Layers in Sonora State, Mexico.

Author

Luna-Castrejón, Linda Patricia, Buter, Rianne, Pantoja-Nuñez, Gabriel Iván, Acuña-Yanes, Martín, Ceballos-Valenzuela, Karla, Talavera-Rojas, Martín, Salgado-Miranda, Celene, Heuvelink, Annet, de Wit, Sjaak, Soriano-Vargas, Edgardo, and Feberwee, Anneke

Subjects
COMMON cold, SEQUENCE analysis, ERYTHROMYCIN, SEROTYPING, RIBOSOMAL RNA
Abstract

Copyright of Avian Diseases is the property of American Association of Avian Pathologists, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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50. Prevalence and genetic characterization of Shiga toxin-producing Escherichia coli isolates from slaughtered animals in Bangladesh

Author

Islam, Mohammad A., Mondol, Abdus S., de Boer, Enne, Beumer, Rijkelt R., Zwietering, Marcel H., Talukder, Kaisar A., and Heuvelink, Annet E.

Subjects
Escherichia coli -- Research, Escherichia coli -- Risk factors, Meat -- Contamination, Biological sciences
Abstract

The prevalence of Shiga toxin (Stx)-producing Escherichia coli (STEC) in feces collected from buffalo, cows and goats slaughtered for meat production in Bangladesh is determined. The results have shown that slaughtered animals like buffalo, cows and goats in Bangladesh are reservoirs for STEC, which has included the potentially virulent STEC strain O157.

Published
2008

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