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BACKGROUND AND OBJECTIVES: Epilepsies are associated with differences in cortical thickness (TH) and surface area (SA). However, the mechanisms underlying these relationships remain elusive. We investigated the extent to which these phenotypes share genetic influences. METHODS: We analyzed genome-wide association study data on common epilepsies (n = 69,995) and TH and SA (n = 32,877) using Gaussian mixture modeling MiXeR and conjunctional false discovery rate (conjFDR) analysis to quantify their shared genetic architecture and identify overlapping loci. We biologically interrogated the loci using a variety of resources and validated in independent samples. RESULTS: The epilepsies (2.4 k-2.9 k variants) were more polygenic than both SA (1.8 k variants) and TH (1.3 k variants). Despite absent genome-wide genetic correlations, there was a substantial genetic overlap between SA and genetic generalized epilepsy (GGE) (1.1 k), all epilepsies (1.1 k), and juvenile myoclonic epilepsy (JME) (0.7 k), as well as between TH and GGE (0.8 k), all epilepsies (0.7 k), and JME (0.8 k), estimated with MiXeR. Furthermore, conjFDR analysis identified 15 GGE loci jointly associated with SA and 15 with TH, 3 loci shared between SA and childhood absence epilepsy, and 6 loci overlapping between SA and JME. 23 loci were novel for epilepsies and 11 for cortical morphology. We observed a high degree of sign concordance in the independent samples. DISCUSSION: Our findings show extensive genetic overlap between generalized epilepsies and cortical morphology, indicating a complex genetic relationship with mixed-effect directions. The results suggest that shared genetic influences may contribute to cortical abnormalities in epilepsies.

Robotaxi services, or rideshare operated by autonomous vehicles, present an opportunity for independent and convenient transportation for people with disabilities. The proliferation of robotaxis in California has been met with mixed reactions from the disability community. To better understand perceptions of and expectations for robotaxis, this report uses semi-structured interviews with representatives from disability advocacy organizations. For many people with disabilities, especially for people with intellectual, developmental, and/or physical disabilities, robotaxis are inaccessible. Given the intricacies of accommodating a wide audience, not all interviewees were confident that robotaxi design and programming will be inclusive. Some interviewees trusted that autonomous vehicle companies will independently pursue accessibility features in their robotaxis. Other interviewees regarded statewide accessibility standards as essential to ensure accessibility. Overall, interviewees shared that people with disabilities want to be included in the process of designing, testing, and regulating robotaxis. Implications for accessible robotaxi governance in California is presented, with an emphasis on wheelchair access, considering impact on public transportation service, and centering people with disabilities. Interviewees also discussed ideal accommodations that would allow a broad audience to request a ride, board the robotaxi, communicate with the operation system, and exit the vehicle. These findings may be useful to AV companies as they consider how robotaxis can accommodate people with a variety of disabilities.

Biting midge-borne bluetongue virus (BTV), an Orbivirus of the Sedoreoviridae family, can cause epizootic disease in domestic and wild ruminants (2). Bluetongue (BT) is a World Organisation for Animal Health-listed [...]

Emblems (also called conventional gestures) are a powerful, yet often overlooked part of humans' communicative tool-kit. These gestures rapidly express encapsulated messages, such as waving a hand to greet someone and shoulder shrugging to reveal a lack of knowledge. We hypothesized that emblems are shaped by a universal pressure to reveal their communicative purpose, and they should therefore be unconfounded with movement typically produced to accomplish non-communicative goals. We present evidence for this hypothesis using a novel dataset of over 250 emblems from around the world: Over 95% of these gestures have forms that support observers' inferences, suggesting that emblems are shaped to ease observers' inferential burden. Finally, in a gesture-creation experiment, we show that these inference-guiding features emerge spontaneously without the need for observer feedback or cultural transmission. Taken together, these complementary approaches provide insight into how goal inferential processes may explain the shape of communicative actions across cultures.

Oxford Street is the western boundary of University of California, Berkeley campus and connects the university to downtown Berkeley and the BART station. Oxford for All is a vision developed by the UC Berkeley Department of City and Regional Planning Transportation Studio that envisions an Oxford Street that seeks to serve all users, regardless of ability or mode choice.To better understand the planning context and needs of the corridor’s residents, the project team conducted the following: Historical context research, Academic literature review, Review of relevant planning documents and plans, Interviews with professional and academic subject matter experts, Case studies of other urban university campuses, Review of planned developments, Pedestrian and cyclist counts, Community outreach event, Survey of businesses.This work revealed that Oxford Street does not serve all road users adequately. The street design prioritizes driving, with wide streets, narrow sidewalks, and poor facilities for pedestrians and bicyclists. The lack of character means the street is a psychological boundary between Berkeley’s downtown and campus.

Abstract Objective The Salzburg EEG criteria for nonconvulsive status epilepticus (NCSE) have been proposed as consensus criteria for NCSE. We aimed to perform an independent study of their diagnostic accuracy. Methods A prospective study was carried out at Oslo University Hospital, including all consecutive patients ≥15 years old who were referred for an EEG with an explicit or implicit question of NCSE from February 2020 to February 2022. Two independent EEG readers scored the included EEGs according to the Salzburg criteria and blinded to the clinical data. The reference standard was defined as the clinical diagnosis the patient received based on all available clinical and paraclinical data. Diagnostic accuracy in identifying “certain/possible NCSE” was assessed by calculating sensitivity, specificity, positive predictive value, and negative predictive value with their 95% confidence intervals. Results In total, 469 patients/EEGs were included in the study. The prevalence of NCSE according to the reference standard was 11% (n = 53). The criteria showed a sensitivity of 94% (95% CI: 92–96%), a specificity of 77% (95% CI: 73–81%), a positive predictive value of 34% (95% CI: 30–39%), and a negative predictive value of 99% (95% CI: 98–100%). False positives for “certain NCSE” (n = 16) included many serial seizures and stimulus‐induced rhythmic and periodic discharges (SIRPIDs), as well as a focal cortical dysplasia. False positives for “possible NCSE” (n = 79) were mainly represented by different encephalopathies and postictality. Interpretation The low specificity of the Salzburg criteria calls for refinement before implementation into daily clinical practice.

Abstract Background Society is experiencing an increasing shift in the age distribution and accordingly, increased resuscitation rates of patients over 80 years and older. In 2022, more than 34% of people resuscitated in Germany were older than 80 years, although older age is considered a poor predictor for the outcome of cardiopulmonary resuscitation (CPR). Professional societies provide ethical recommendations on when resuscitation may be considered futile and should be terminated. However, the extent to which these recommendations are implemented is unclear. Methods Retrospective evaluation of pre-hospital documentation of out-of-hospital resuscitations in patients ≥ 80 years of age in the period 01/01/2014–12/31/2022 in one German county combined with data of the German Resuscitation Registry. For statistical testing, the significance level was set at p

The Alpine nappe stack in the Penninic-Austroalpine boundary zone in the Rätikon (Austria) contains a 4×1 km tectonic sliver of meta-diorite, known as the Schwarzhorn Amphibolite. It was deformed and metamorphosed in the amphibolite facies and is unconformably overlain by unmetamorphic Lower Triassic sandstone, indicating pre-Triassic metamorphism. Cataclastic deformation and brecciation of the amphibolite is related to normal faulting and block tilting during Jurassic rifting. Zircon dating of the Schwarzhorn Amphibolite using LA-ICP-MS gave a U-Pb age of 529+9/-8 Ma, interpreted as the crystallization age of the protolith. Geochemical characteristics indicate formation of the magmatic protolith in a supra-subduction zone setting. The Cambrian protolith age identifies the Schwarzhorn Amphibolite as a pre-Variscan element within the Austroalpine basement. Similar calc-alkaline igneous rocks of Late Neoproterozoic to Early Cambrian age are found in the Upper Austroalpine Silvretta Nappe nearby and in several other Variscan basement units of the Alps, interpreted to have formed in a peri-Gondwanan active-margin or island-arc setting.