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1. High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency–Associated Genomic Instability in Ovarian Cancer

Author

Pfarr, Nicole, von Schwarzenberg, Karin, Zocholl, Dario, Merkelbach-Bruse, Sabine, Siemanowski, Janna, Mayr, Eva-Maria, Herold, Sylvia, Kleo, Karsten, Heukamp, Lukas C., Willing, Eva-Maria, Menzel, Michael, Lehmann, Ulrich, Bartels, Stephan, Chakraborty, Shounak, Baretton, Gustavo, Demes, Melanie C., Döring, Claudia, Kazdal, Daniel, Budczies, Jan, Rad, Roland, Wild, Peter, Christinat, Yann, McKee, Thomas, Schirmacher, Peter, Horst, David, Büttner, Reinhard, Stenzinger, Albrecht, Sehouli, Jalid, Vollbrecht, Claudia, Hummel, Michael, Braicu, Elena I., and Weichert, Wilko

Published
2024
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2. Targeting KDM1A in Neuroblastoma with NCL-1 Induces a Less Aggressive Phenotype and Suppresses Angiogenesis.

Author

Sprüssel, Annika, Suzuki, Takayoshi, Miyata, Naoki, Astrahantseff, Kathy, Szymansky, Annabell, Toedling, Joern, Thole-Kliesch, Theresa M., Ballagee, Annika, Lodrini, Marco, Künkele, Annette, Truss, Matthias, Heukamp, Lukas C., Mathia, Susanne, Hertwig, Falk, Rosenberger, Christian, Eggert, Angelika, Deubzer, Hedwig E., and Schulte, Johannes H.

Subjects
TUMOR growth, CHILDHOOD cancer, NEURONAL differentiation, CELL proliferation, SMALL molecules, NEUROBLASTOMA
Abstract

Background: The KDM1A histone demethylase regulates the cellular balance between proliferation and differentiation, and is often deregulated in human cancers including the childhood tumor neuroblastoma. We previously showed that KDM1A is strongly expressed in undifferentiated neuroblastomas and correlates with poor patient prognosis, suggesting a possible clinical benefit from targeting KDM1A. Methods: Here, we tested the efficacy of NCL-1, a small molecule specifically inhibiting KDM1A in preclinical models for neuroblastoma. Results: NCL-1 mimicked the effects of siRNA-mediated KDM1A knockdown and effectively inhibited KDM1A activity in four neuroblastoma cell lines and a patient-representative cell model. KDM1A inhibition shifted the aggressive tumor cell phenotypes towards less aggressive phenotypes. The proliferation and cell viability was reduced, accompanied by the induction of markers of neuronal differentiation. Interventional NCL-1 treatment of nude mice harboring established neuroblastoma xenograft tumors reduced tumor growth and inhibited cell proliferation. Reduced vessel density and defects in blood vessel construction also resulted, and NCL-1 inhibited the growth and tube formation of HUVEC-C cells in vitro. Conclusions: Inhibiting KDM1A could attack aggressive neuroblastomas two-fold, by re-directing tumor cells toward a less aggressive, slower-growing phenotype and by preventing or reducing the vascular support of large tumors. [ABSTRACT FROM AUTHOR]

Published
2024
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5. ALK alterations in salivary gland carcinomas

Author

Majewska, Hanna, Gorczyński, Adam, Czapiewski, Piotr, Menon, Roopika, Mueller, Judith, Lakis, Sotirios, Heuckmann, Johannes M., Laco, Jan, Gupta, Ruta, Andreasen, Simon, Stodulski, Dominik, Iliszko, Mariola, Dziadziuszko, Rafał, Jassem, Jacek, Heukamp, Lukas C., and Biernat, Wojciech

Published
2021
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6. Diagnostik und Therapie von Tumoren mit NTRK-Genfusionen

Author

Stenzinger, Albrecht, van Tilburg, Cornelis M., Tabatabai, Ghazaleh, Länger, Florian, Graf, Norbert, Griesinger, Frank, Heukamp, Lukas C., Hummel, Michael, Klingebiel, Thomas, Hettmer, Simone, Vokuhl, Christian, Merkelbach-Bruse, Sabine, Overkamp, Friedrich, Reichardt, Peter, Scheer, Monika, Weichert, Wilko, Westphalen, C. Benedikt, Bokemeyer, Carsten, Ivanyi, Philipp, Loges, Sonja, Schirmacher, Peter, Wörmann, Bernhard, Bielack, Stefan, and Seufferlein, Thomas T. W.

Published
2021
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7. Comprehensive genomic profiles of small cell lung cancer

Author

George, Julie, Lim, Jing Shan, Jang, Se Jin, Cun, Yupeng, Ozretić, Luka, Kong, Gu, Leenders, Frauke, Lu, Xin, Fernández-Cuesta, Lynnette, Bosco, Graziella, Müller, Christian, Dahmen, Ilona, Jahchan, Nadine S, Park, Kwon-Sik, Yang, Dian, Karnezis, Anthony N, Vaka, Dedeepya, Torres, Angela, Wang, Maia Segura, Korbel, Jan O, Menon, Roopika, Chun, Sung-Min, Kim, Deokhoon, Wilkerson, Matt, Hayes, Neil, Engelmann, David, Pützer, Brigitte, Bos, Marc, Michels, Sebastian, Vlasic, Ignacija, Seidel, Danila, Pinther, Berit, Schaub, Philipp, Becker, Christian, Altmüller, Janine, Yokota, Jun, Kohno, Takashi, Iwakawa, Reika, Tsuta, Koji, Noguchi, Masayuki, Muley, Thomas, Hoffmann, Hans, Schnabel, Philipp A, Petersen, Iver, Chen, Yuan, Soltermann, Alex, Tischler, Verena, Choi, Chang-min, Kim, Yong-Hee, Massion, Pierre P, Zou, Yong, Jovanovic, Dragana, Kontic, Milica, Wright, Gavin M, Russell, Prudence A, Solomon, Benjamin, Koch, Ina, Lindner, Michael, Muscarella, Lucia A, la Torre, Annamaria, Field, John K, Jakopovic, Marko, Knezevic, Jelena, Castaños-Vélez, Esmeralda, Roz, Luca, Pastorino, Ugo, Brustugun, Odd-Terje, Lund-Iversen, Marius, Thunnissen, Erik, Köhler, Jens, Schuler, Martin, Botling, Johan, Sandelin, Martin, Sanchez-Cespedes, Montserrat, Salvesen, Helga B, Achter, Viktor, Lang, Ulrich, Bogus, Magdalena, Schneider, Peter M, Zander, Thomas, Ansén, Sascha, Hallek, Michael, Wolf, Jürgen, Vingron, Martin, Yatabe, Yasushi, Travis, William D, Nürnberg, Peter, Reinhardt, Christian, Perner, Sven, Heukamp, Lukas, Büttner, Reinhard, Haas, Stefan A, Brambilla, Elisabeth, Peifer, Martin, Sage, Julien, and Thomas, Roman K

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Human Genome, Cancer, Rare Diseases, Lung, Lung Cancer, Aetiology, 2.1 Biological and endogenous factors, Alleles, Animals, Cell Line, Tumor, Chromosome Breakpoints, Cyclin D1, DNA-Binding Proteins, Disease Models, Animal, Female, Gene Expression Profiling, Genome, Human, Genomics, Humans, Lung Neoplasms, Male, Mice, Mutation, Neurosecretory Systems, Nuclear Proteins, Receptors, Notch, Retinoblastoma Protein, Signal Transduction, Small Cell Lung Carcinoma, Tumor Protein p73, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, General Science & Technology
Abstract

We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes by complex genomic rearrangements. Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1 gene), revealing an alternative mechanism of Rb1 deregulation. Thus, loss of the tumour suppressors TP53 and RB1 is obligatory in SCLC. We discovered somatic genomic rearrangements of TP73 that create an oncogenic version of this gene, TP73Δex2/3. In rare cases, SCLC tumours exhibited kinase gene mutations, providing a possible therapeutic opportunity for individual patients. Finally, we observed inactivating mutations in NOTCH family genes in 25% of human SCLC. Accordingly, activation of Notch signalling in a pre-clinical SCLC mouse model strikingly reduced the number of tumours and extended the survival of the mutant mice. Furthermore, neuroendocrine gene expression was abrogated by Notch activity in SCLC cells. This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer.

Published
2015

8. Safety and Efficacy of Crizotinib in Patients With Advanced or Metastatic ROS1-Rearranged Lung Cancer (EUCROSS): A European Phase II Clinical Trial

Author

Michels, Sebastian, Massutí, Bartomeu, Schildhaus, Hans-Ulrich, Franklin, Jeremy, Sebastian, Martin, Felip, Enriqueta, Grohé, Christian, Rodriguez-Abreu, Delvys, Abdulla, Diana S.Y., Bischoff, Helge, Brandts, Christian, Carcereny, Enric, Corral, Jesús, Dingemans, Anne-Marie C., Pereira, Eva, Fassunke, Jana, Fischer, Rieke N., Gardizi, Masyar, Heukamp, Lukas, Insa, Amelia, Kron, Anna, Menon, Roopika, Persigehl, Thorsten, Reck, Martin, Riedel, Richard, Rothschild, Sacha I., Scheel, Andreas H., Scheffler, Matthias, Schmalz, Petra, Smit, Egbert F., Limburg, Meike, Provencio, Mariano, Karachaliou, Niki, Merkelbach-Bruse, Sabine, Hellmich, Martin, Nogova, Lucia, Büttner, Reinhard, Rosell, Rafael, and Wolf, Jürgen

Published
2019
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9. PO009/#424 Innovative academic homologous recombination deficiency tests available in advanced ovarian cancer: the European ENGOT initiative

Author

Pujade-Lauraine, Eric, primary, Christinat, Yann, additional, D’Incalci, Maurizio, additional, Schouten, Philip C, additional, Buisson, Adrien, additional, Heukamp, Lukas C, additional, Loverix, Liselore, additional, Callens, Celine, additional, Leman, Raphael, additional, Mckee, Thomas A, additional, Marchini, Sergio, additional, Hahnen, Eric, additional, Saintigny, Pierre, additional, Braicu, Elena Ioana, additional, Gorp, Toon Van, additional, Yaniz-Galende, Elisa, additional, Stern, Marc-Henri, additional, Vaur, Dominique, additional, and Ray-Coquard, Isabelle, additional

Published
2023
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12. Development of the NOGGO GIS v1 Assay, a Comprehensive Hybrid-Capture-Based NGS Assay for Therapeutic Stratification of Homologous Repair Deficiency Driven Tumors and Clinical Validation

Author

Willing, Eva-Maria, primary, Vollbrecht, Claudia, additional, Vössing, Christine, additional, Weist, Peggy, additional, Schallenberg, Simon, additional, Herbst, Johanna M., additional, Schatz, Stefanie, additional, Jóri, Balázs, additional, Bataillon, Guillaume, additional, Harter, Philipp, additional, Salutari, Vanda, additional, Martin, Antonio Gonzáles, additional, Vergote, Ignace, additional, Colombo, Nicoletta, additional, Roeper, Julia, additional, Berg, Tobias, additional, Berger, Regina, additional, Kah, Bettina, additional, Noettrup, Trine Jakobi, additional, Falk, Markus, additional, Arndt, Kathrin, additional, Polten, Andreas, additional, Ray-Coquard, Isabelle, additional, Selzam, Franziska, additional, Pirngruber, Judith, additional, Schmidt, Stefanie, additional, Hummel, Michael, additional, Tiemann, Markus, additional, Horst, David, additional, Sehouli, Jalid, additional, Pujade-Lauraine, Eric, additional, Tiemann, Katharina, additional, Braicu, Elena Ioana, additional, and Heukamp, Lukas C., additional

Published
2023
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15. Synaptopodin-2 Isoforms Have Specific Binding Partners and Display Distinct, Muscle Cell Type-Specific Expression Patterns.

Author

Lohanadan, Keerthika, Assent, Marvin, Linnemann, Anja, Schuld, Julia, Heukamp, Lukas C., Krause, Karsten, Vorgerd, Matthias, Reimann, Jens, Schänzer, Anne, Kirfel, Gregor, Fürst, Dieter O., and Van der Ven, Peter F. M.

Subjects
MUSCLE cells, GENE expression, INTERMEDIATE filament proteins, ALTERNATIVE RNA splicing, STRIATED muscle, SKELETAL muscle, HEART, DEVELOPMENTAL neurobiology
Abstract

Synaptopodin-2 (SYNPO2) is a protein associated with the Z-disc in striated muscle cells. It interacts with α-actinin and filamin C, playing a role in Z-disc maintenance under stress by chaperone-assisted selective autophagy (CASA). In smooth muscle cells, SYNPO2 is a component of dense bodies. Furthermore, it has been proposed to play a role in tumor cell proliferation and metastasis in many different kinds of cancers. Alternative transcription start sites and alternative splicing predict the expression of six putative SYNPO2 isoforms differing by extended amino- and/or carboxy-termini. Our analyses at mRNA and protein levels revealed differential expression of SYNPO2 isoforms in cardiac, skeletal and smooth muscle cells. We identified synemin, an intermediate filament protein, as a novel binding partner of the PDZ-domain in the amino-terminal extension of the isoforms mainly expressed in cardiac and smooth muscle cells, and demonstrated colocalization of SYNPO2 and synemin in both cell types. A carboxy-terminal extension, mainly expressed in smooth muscle cells, is sufficient for association with dense bodies and interacts with α-actinin. SYNPO2 therefore represents an additional and novel link between intermediate filaments and the Z-discs in cardiomyocytes and dense bodies in smooth muscle cells, respectively. In pathological skeletal muscle samples, we identified SYNPO2 in the central and intermediate zones of target fibers of patients with neurogenic muscular atrophy, and in nemaline bodies. Our findings help to understand distinct functions of individual SYNPO2 isoforms in different muscle tissues, but also in tumor pathology. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Cellular immune responses against the tumour associated polymorphic epithelial mucin MUC1

Author

Heukamp, Lukas Carl

Subjects
616.994
Abstract

The human epithelial mucin MUC1 is expressed on the apical surface of a large number of normal epithelial tissues, including the ducts of the breast, ovary, pancreas, lung and colon. Adenocarcinomata that arise from these tissues can show marked over expression of MUC1, as well as aberrant glycosylation and loss of apical distribution of this mucin. These observations led to the attempt to use MUC1 a potential target for tumour immunotherapy. The work described in this thesis aims to evaluate cellular immune responses directed against the MUC1 antigen, using mouse model systems. The project addresses fundamental questions relating to the feasibility of using MUC1-based antigens for tumour immunotherapy, and has led to the identification of MHC class I-restricted epitopes both in mice and in humans; that may have clinical relevance. Firstly, the induction of MUC1-specific CTL lines and their characterisation in a C57BL/6 mouse model is described. This includes mapping of the dominant CTL epitope recognised by MUC1-specific CTL and analysis of anti-tumour effects of these CTL in vivo. Adoptive transfer of CTL cultured in vitro into MUC1 transgenic mice, where human MUC1 is expressed as a self antigen, has allowed evaluation of immunogenicity and tumour protection in a setting in which autoimmunity may occur. The results demonstrate that the host can tolerate effective anti-tumour immune responses to MUC1 without induction of autoimmunity. The second major part of the work aimed to identify human MHC class I-restricted MUC1-derived epitopes. The merits of the different possible approaches for epitope identification are discussed and the identification of HLA A*0201-restricted epitopes is described. Potential MHC binding peptides were identified by motif scoring. These peptides were then analysed for binding and complex stability with HLA-A*0201. The immunogenicity and physiological relevance of these peptides is shown by induction of CTL responses and tumour protection in a transgenic mouse model expressing HLA A*0201-Kb.

Published
2000

18. Data from CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, primary, Osada, Hirotaka, primary, Sun, Ruping, primary, Menon, Roopika, primary, Leenders, Frauke, primary, Ortiz-Cuaran, Sandra, primary, Peifer, Martin, primary, Bos, Marc, primary, Daßler, Juliane, primary, Malchers, Florian, primary, Schöttle, Jakob, primary, Vogel, Wenzel, primary, Dahmen, Ilona, primary, Koker, Mirjam, primary, Ullrich, Roland T., primary, Wright, Gavin M., primary, Russell, Prudence A., primary, Wainer, Zoe, primary, Solomon, Benjamin, primary, Brambilla, Elisabeth, primary, Nagy-Mignotte, Hélène, primary, Moro-Sibilot, Denis, primary, Brambilla, Christian G., primary, Lantuejoul, Sylvie, primary, Altmüller, Janine, primary, Becker, Christian, primary, Nürnberg, Peter, primary, Heuckmann, Johannes M., primary, Stoelben, Erich, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Sänger, Jörg, primary, Muscarella, Lucia A., primary, la Torre, Annamaria, primary, Fazio, Vito M., primary, Lahortiga, Idoya, primary, Perera, Timothy, primary, Ogata, Souichi, primary, Parade, Marc, primary, Brehmer, Dirk, primary, Vingron, Martin, primary, Heukamp, Lukas C., primary, Buettner, Reinhard, primary, Zander, Thomas, primary, Wolf, Jürgen, primary, Perner, Sven, primary, Ansén, Sascha, primary, Haas, Stefan A., primary, Yatabe, Yasushi, primary, and Thomas, Roman K., primary

Published
2023
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20. Data from Cell-Autonomous and Non–Cell-Autonomous Mechanisms of Transformation by Amplified FGFR1 in Lung Cancer

Author

Malchers, Florian, primary, Dietlein, Felix, primary, Schöttle, Jakob, primary, Lu, Xin, primary, Nogova, Lucia, primary, Albus, Kerstin, primary, Fernandez-Cuesta, Lynnette, primary, Heuckmann, Johannes M., primary, Gautschi, Oliver, primary, Diebold, Joachim, primary, Plenker, Dennis, primary, Gardizi, Masyar, primary, Scheffler, Matthias, primary, Bos, Marc, primary, Seidel, Danila, primary, Leenders, Frauke, primary, Richters, André, primary, Peifer, Martin, primary, Florin, Alexandra, primary, Mainkar, Prathama S., primary, Karre, Nagaraju, primary, Chandrasekhar, Srivari, primary, George, Julie, primary, Silling, Steffi, primary, Rauh, Daniel, primary, Zander, Thomas, primary, Ullrich, Roland T., primary, Reinhardt, H. Christian, primary, Ringeisen, Francois, primary, Büttner, Reinhard, primary, Heukamp, Lukas C., primary, Wolf, Jürgen, primary, and Thomas, Roman K., primary

Published
2023
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21. Supplementary Tables from CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, primary, Osada, Hirotaka, primary, Sun, Ruping, primary, Menon, Roopika, primary, Leenders, Frauke, primary, Ortiz-Cuaran, Sandra, primary, Peifer, Martin, primary, Bos, Marc, primary, Daßler, Juliane, primary, Malchers, Florian, primary, Schöttle, Jakob, primary, Vogel, Wenzel, primary, Dahmen, Ilona, primary, Koker, Mirjam, primary, Ullrich, Roland T., primary, Wright, Gavin M., primary, Russell, Prudence A., primary, Wainer, Zoe, primary, Solomon, Benjamin, primary, Brambilla, Elisabeth, primary, Nagy-Mignotte, Hélène, primary, Moro-Sibilot, Denis, primary, Brambilla, Christian G., primary, Lantuejoul, Sylvie, primary, Altmüller, Janine, primary, Becker, Christian, primary, Nürnberg, Peter, primary, Heuckmann, Johannes M., primary, Stoelben, Erich, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Sänger, Jörg, primary, Muscarella, Lucia A., primary, la Torre, Annamaria, primary, Fazio, Vito M., primary, Lahortiga, Idoya, primary, Perera, Timothy, primary, Ogata, Souichi, primary, Parade, Marc, primary, Brehmer, Dirk, primary, Vingron, Martin, primary, Heukamp, Lukas C., primary, Buettner, Reinhard, primary, Zander, Thomas, primary, Wolf, Jürgen, primary, Perner, Sven, primary, Ansén, Sascha, primary, Haas, Stefan A., primary, Yatabe, Yasushi, primary, and Thomas, Roman K., primary

Published
2023
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23. Supplementary Methods and Legends from Cell-Autonomous and Non–Cell-Autonomous Mechanisms of Transformation by Amplified FGFR1 in Lung Cancer

Author

Malchers, Florian, primary, Dietlein, Felix, primary, Schöttle, Jakob, primary, Lu, Xin, primary, Nogova, Lucia, primary, Albus, Kerstin, primary, Fernandez-Cuesta, Lynnette, primary, Heuckmann, Johannes M., primary, Gautschi, Oliver, primary, Diebold, Joachim, primary, Plenker, Dennis, primary, Gardizi, Masyar, primary, Scheffler, Matthias, primary, Bos, Marc, primary, Seidel, Danila, primary, Leenders, Frauke, primary, Richters, André, primary, Peifer, Martin, primary, Florin, Alexandra, primary, Mainkar, Prathama S., primary, Karre, Nagaraju, primary, Chandrasekhar, Srivari, primary, George, Julie, primary, Silling, Steffi, primary, Rauh, Daniel, primary, Zander, Thomas, primary, Ullrich, Roland T., primary, Reinhardt, H. Christian, primary, Ringeisen, Francois, primary, Büttner, Reinhard, primary, Heukamp, Lukas C., primary, Wolf, Jürgen, primary, and Thomas, Roman K., primary

Published
2023
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25. Supplementary Figures S1-S14 from Cell-Autonomous and Non–Cell-Autonomous Mechanisms of Transformation by Amplified FGFR1 in Lung Cancer

Author

Malchers, Florian, primary, Dietlein, Felix, primary, Schöttle, Jakob, primary, Lu, Xin, primary, Nogova, Lucia, primary, Albus, Kerstin, primary, Fernandez-Cuesta, Lynnette, primary, Heuckmann, Johannes M., primary, Gautschi, Oliver, primary, Diebold, Joachim, primary, Plenker, Dennis, primary, Gardizi, Masyar, primary, Scheffler, Matthias, primary, Bos, Marc, primary, Seidel, Danila, primary, Leenders, Frauke, primary, Richters, André, primary, Peifer, Martin, primary, Florin, Alexandra, primary, Mainkar, Prathama S., primary, Karre, Nagaraju, primary, Chandrasekhar, Srivari, primary, George, Julie, primary, Silling, Steffi, primary, Rauh, Daniel, primary, Zander, Thomas, primary, Ullrich, Roland T., primary, Reinhardt, H. Christian, primary, Ringeisen, Francois, primary, Büttner, Reinhard, primary, Heukamp, Lukas C., primary, Wolf, Jürgen, primary, and Thomas, Roman K., primary

Published
2023
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27. Supplementary Figures from CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, primary, Osada, Hirotaka, primary, Sun, Ruping, primary, Menon, Roopika, primary, Leenders, Frauke, primary, Ortiz-Cuaran, Sandra, primary, Peifer, Martin, primary, Bos, Marc, primary, Daßler, Juliane, primary, Malchers, Florian, primary, Schöttle, Jakob, primary, Vogel, Wenzel, primary, Dahmen, Ilona, primary, Koker, Mirjam, primary, Ullrich, Roland T., primary, Wright, Gavin M., primary, Russell, Prudence A., primary, Wainer, Zoe, primary, Solomon, Benjamin, primary, Brambilla, Elisabeth, primary, Nagy-Mignotte, Hélène, primary, Moro-Sibilot, Denis, primary, Brambilla, Christian G., primary, Lantuejoul, Sylvie, primary, Altmüller, Janine, primary, Becker, Christian, primary, Nürnberg, Peter, primary, Heuckmann, Johannes M., primary, Stoelben, Erich, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Sänger, Jörg, primary, Muscarella, Lucia A., primary, la Torre, Annamaria, primary, Fazio, Vito M., primary, Lahortiga, Idoya, primary, Perera, Timothy, primary, Ogata, Souichi, primary, Parade, Marc, primary, Brehmer, Dirk, primary, Vingron, Martin, primary, Heukamp, Lukas C., primary, Buettner, Reinhard, primary, Zander, Thomas, primary, Wolf, Jürgen, primary, Perner, Sven, primary, Ansén, Sascha, primary, Haas, Stefan A., primary, Yatabe, Yasushi, primary, and Thomas, Roman K., primary

Published
2023
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28. Supplementary Figure 3 from Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors

Author

Ortiz-Cuaran, Sandra, primary, Scheffler, Matthias, primary, Plenker, Dennis, primary, Dahmen, llona, primary, Scheel, Andreas H., primary, Fernandez-Cuesta, Lynnette, primary, Meder, Lydia, primary, Lovly, Christine M., primary, Persigehl, Thorsten, primary, Merkelbach-Bruse, Sabine, primary, Bos, Marc, primary, Michels, Sebastian, primary, Fischer, Rieke, primary, Albus, Kerstin, primary, König, Katharina, primary, Schildhaus, Hans-Ulrich, primary, Fassunke, Jana, primary, Ihle, Michaela A., primary, Pasternack, Helen, primary, Heydt, Carina, primary, Becker, Christian, primary, Altmüller, Janine, primary, Ji, Hongbin, primary, Müller, Christian, primary, Florin, Alexandra, primary, Heuckmann, Johannes M., primary, Nuernberg, Peter, primary, Ansén, Sascha, primary, Heukamp, Lukas C., primary, Berg, Johannes, primary, Pao, William, primary, Peifer, Martin, primary, Buettner, Reinhard, primary, Wolf, Jürgen, primary, Thomas, Roman K., primary, and Sos, Martin L., primary

Published
2023
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29. MYCN targets OTX015_BRD4 and gene expression from Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition

Author

Henssen, Anton, primary, Althoff, Kristina, primary, Odersky, Andrea, primary, Beckers, Anneleen, primary, Koche, Richard, primary, Speleman, Frank, primary, Schäfers, Simon, primary, Bell, Emma, primary, Nortmeyer, Maike, primary, Westermann, Frank, primary, De Preter, Katleen, primary, Florin, Alexandra, primary, Heukamp, Lukas, primary, Spruessel, Annika, primary, Astrahanseff, Kathy, primary, Lindner, Sven, primary, Sadowski, Natalie, primary, Schramm, Alexander, primary, Astorgues-Xerri, Lucile, primary, Riveiro, Maria E., primary, Eggert, Angelika, primary, Cvitkovic, Esteban, primary, and Schulte, Johannes H., primary

Published
2023
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30. Supplementary Figure 2. from Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition

Author

Henssen, Anton, primary, Althoff, Kristina, primary, Odersky, Andrea, primary, Beckers, Anneleen, primary, Koche, Richard, primary, Speleman, Frank, primary, Schäfers, Simon, primary, Bell, Emma, primary, Nortmeyer, Maike, primary, Westermann, Frank, primary, De Preter, Katleen, primary, Florin, Alexandra, primary, Heukamp, Lukas, primary, Spruessel, Annika, primary, Astrahanseff, Kathy, primary, Lindner, Sven, primary, Sadowski, Natalie, primary, Schramm, Alexander, primary, Astorgues-Xerri, Lucile, primary, Riveiro, Maria E., primary, Eggert, Angelika, primary, Cvitkovic, Esteban, primary, and Schulte, Johannes H., primary

Published
2023
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31. Supplemental Table 8 from Clinical and Pathological Characteristics of KEAP1- and NFE2L2-Mutated Non–Small Cell Lung Carcinoma (NSCLC)

Author

Frank, Rieke, primary, Scheffler, Matthias, primary, Merkelbach-Bruse, Sabine, primary, Ihle, Michaela A., primary, Kron, Anna, primary, Rauer, Michael, primary, Ueckeroth, Frank, primary, König, Katharina, primary, Michels, Sebastian, primary, Fischer, Rieke, primary, Eisert, Anna, primary, Fassunke, Jana, primary, Heydt, Carina, primary, Serke, Monika, primary, Ko, Yon-Dschun, primary, Gerigk, Ulrich, primary, Geist, Thomas, primary, Kaminsky, Britta, primary, Heukamp, Lukas C., primary, Clement-Ziza, Mathieu, primary, Büttner, Reinhard, primary, and Wolf, Jürgen, primary

Published
2023
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32. Supplementary Figure Legends 1-7 from Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants

Author

Heuckmann, Johannes M., primary, Balke-Want, Hyatt, primary, Malchers, Florian, primary, Peifer, Martin, primary, Sos, Martin L., primary, Koker, Mirjam, primary, Meder, Lydia, primary, Lovly, Christine M., primary, Heukamp, Lukas C., primary, Pao, William, primary, Küppers, Ralf, primary, and Thomas, Roman K., primary

Published
2023
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33. Supplementary Figure 2 from Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors

Author

Ortiz-Cuaran, Sandra, primary, Scheffler, Matthias, primary, Plenker, Dennis, primary, Dahmen, llona, primary, Scheel, Andreas H., primary, Fernandez-Cuesta, Lynnette, primary, Meder, Lydia, primary, Lovly, Christine M., primary, Persigehl, Thorsten, primary, Merkelbach-Bruse, Sabine, primary, Bos, Marc, primary, Michels, Sebastian, primary, Fischer, Rieke, primary, Albus, Kerstin, primary, König, Katharina, primary, Schildhaus, Hans-Ulrich, primary, Fassunke, Jana, primary, Ihle, Michaela A., primary, Pasternack, Helen, primary, Heydt, Carina, primary, Becker, Christian, primary, Altmüller, Janine, primary, Ji, Hongbin, primary, Müller, Christian, primary, Florin, Alexandra, primary, Heuckmann, Johannes M., primary, Nuernberg, Peter, primary, Ansén, Sascha, primary, Heukamp, Lukas C., primary, Berg, Johannes, primary, Pao, William, primary, Peifer, Martin, primary, Buettner, Reinhard, primary, Wolf, Jürgen, primary, Thomas, Roman K., primary, and Sos, Martin L., primary

Published
2023
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34. Supplementary Data from Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors

Author

Ortiz-Cuaran, Sandra, primary, Scheffler, Matthias, primary, Plenker, Dennis, primary, Dahmen, llona, primary, Scheel, Andreas H., primary, Fernandez-Cuesta, Lynnette, primary, Meder, Lydia, primary, Lovly, Christine M., primary, Persigehl, Thorsten, primary, Merkelbach-Bruse, Sabine, primary, Bos, Marc, primary, Michels, Sebastian, primary, Fischer, Rieke, primary, Albus, Kerstin, primary, König, Katharina, primary, Schildhaus, Hans-Ulrich, primary, Fassunke, Jana, primary, Ihle, Michaela A., primary, Pasternack, Helen, primary, Heydt, Carina, primary, Becker, Christian, primary, Altmüller, Janine, primary, Ji, Hongbin, primary, Müller, Christian, primary, Florin, Alexandra, primary, Heuckmann, Johannes M., primary, Nuernberg, Peter, primary, Ansén, Sascha, primary, Heukamp, Lukas C., primary, Berg, Johannes, primary, Pao, William, primary, Peifer, Martin, primary, Buettner, Reinhard, primary, Wolf, Jürgen, primary, Thomas, Roman K., primary, and Sos, Martin L., primary

Published
2023
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35. Supplementary Figures 1-7, Table 1 from Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants

Author

Heuckmann, Johannes M., primary, Balke-Want, Hyatt, primary, Malchers, Florian, primary, Peifer, Martin, primary, Sos, Martin L., primary, Koker, Mirjam, primary, Meder, Lydia, primary, Lovly, Christine M., primary, Heukamp, Lukas C., primary, Pao, William, primary, Küppers, Ralf, primary, and Thomas, Roman K., primary

Published
2023
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36. Supplement from Clinical and Pathological Characteristics of KEAP1- and NFE2L2-Mutated Non–Small Cell Lung Carcinoma (NSCLC)

Author

Frank, Rieke, primary, Scheffler, Matthias, primary, Merkelbach-Bruse, Sabine, primary, Ihle, Michaela A., primary, Kron, Anna, primary, Rauer, Michael, primary, Ueckeroth, Frank, primary, König, Katharina, primary, Michels, Sebastian, primary, Fischer, Rieke, primary, Eisert, Anna, primary, Fassunke, Jana, primary, Heydt, Carina, primary, Serke, Monika, primary, Ko, Yon-Dschun, primary, Gerigk, Ulrich, primary, Geist, Thomas, primary, Kaminsky, Britta, primary, Heukamp, Lukas C., primary, Clement-Ziza, Mathieu, primary, Büttner, Reinhard, primary, and Wolf, Jürgen, primary

Published
2023
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37. CCR Translation for This Article from Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants

Author

Heuckmann, Johannes M., primary, Balke-Want, Hyatt, primary, Malchers, Florian, primary, Peifer, Martin, primary, Sos, Martin L., primary, Koker, Mirjam, primary, Meder, Lydia, primary, Lovly, Christine M., primary, Heukamp, Lukas C., primary, Pao, William, primary, Küppers, Ralf, primary, and Thomas, Roman K., primary

Published
2023
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38. Supplementary Figure 4 from Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors

Author

Ortiz-Cuaran, Sandra, primary, Scheffler, Matthias, primary, Plenker, Dennis, primary, Dahmen, llona, primary, Scheel, Andreas H., primary, Fernandez-Cuesta, Lynnette, primary, Meder, Lydia, primary, Lovly, Christine M., primary, Persigehl, Thorsten, primary, Merkelbach-Bruse, Sabine, primary, Bos, Marc, primary, Michels, Sebastian, primary, Fischer, Rieke, primary, Albus, Kerstin, primary, König, Katharina, primary, Schildhaus, Hans-Ulrich, primary, Fassunke, Jana, primary, Ihle, Michaela A., primary, Pasternack, Helen, primary, Heydt, Carina, primary, Becker, Christian, primary, Altmüller, Janine, primary, Ji, Hongbin, primary, Müller, Christian, primary, Florin, Alexandra, primary, Heuckmann, Johannes M., primary, Nuernberg, Peter, primary, Ansén, Sascha, primary, Heukamp, Lukas C., primary, Berg, Johannes, primary, Pao, William, primary, Peifer, Martin, primary, Buettner, Reinhard, primary, Wolf, Jürgen, primary, Thomas, Roman K., primary, and Sos, Martin L., primary

Published
2023
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39. Supplementary Figure 5. from Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition

Author

Henssen, Anton, primary, Althoff, Kristina, primary, Odersky, Andrea, primary, Beckers, Anneleen, primary, Koche, Richard, primary, Speleman, Frank, primary, Schäfers, Simon, primary, Bell, Emma, primary, Nortmeyer, Maike, primary, Westermann, Frank, primary, De Preter, Katleen, primary, Florin, Alexandra, primary, Heukamp, Lukas, primary, Spruessel, Annika, primary, Astrahanseff, Kathy, primary, Lindner, Sven, primary, Sadowski, Natalie, primary, Schramm, Alexander, primary, Astorgues-Xerri, Lucile, primary, Riveiro, Maria E., primary, Eggert, Angelika, primary, Cvitkovic, Esteban, primary, and Schulte, Johannes H., primary

Published
2023
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40. Supplementary Figure Legends from Transient Antiangiogenic Treatment Improves Delivery of Cytotoxic Compounds and Therapeutic Outcome in Lung Cancer

Author

Chatterjee, Sampurna, primary, Wieczorek, Caroline, primary, Schöttle, Jakob, primary, Siobal, Maike, primary, Hinze, Yvonne, primary, Franz, Thomas, primary, Florin, Alexandra, primary, Adamczak, Joanna, primary, Heukamp, Lukas C., primary, Neumaier, Bernd, primary, and Ullrich, Roland T., primary

Published
2023
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41. Supplementary Figure 2 from SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells

Author

Michels, Sebastian, primary, Trautmann, Marcel, primary, Sievers, Elisabeth, primary, Kindler, Dagmar, primary, Huss, Sebastian, primary, Renner, Marcus, primary, Friedrichs, Nicolaus, primary, Kirfel, Jutta, primary, Steiner, Susanne, primary, Endl, Elmar, primary, Wurst, Peter, primary, Heukamp, Lukas, primary, Penzel, Roland, primary, Larsson, Olle, primary, Kawai, Akira, primary, Tanaka, Shinya, primary, Sonobe, Hiroshi, primary, Schirmacher, Peter, primary, Mechtersheimer, Gunhild, primary, Wardelmann, Eva, primary, Büttner, Reinhard, primary, and Hartmann, Wolfgang, primary

Published
2023
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45. Data from SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells

Author

Michels, Sebastian, primary, Trautmann, Marcel, primary, Sievers, Elisabeth, primary, Kindler, Dagmar, primary, Huss, Sebastian, primary, Renner, Marcus, primary, Friedrichs, Nicolaus, primary, Kirfel, Jutta, primary, Steiner, Susanne, primary, Endl, Elmar, primary, Wurst, Peter, primary, Heukamp, Lukas, primary, Penzel, Roland, primary, Larsson, Olle, primary, Kawai, Akira, primary, Tanaka, Shinya, primary, Sonobe, Hiroshi, primary, Schirmacher, Peter, primary, Mechtersheimer, Gunhild, primary, Wardelmann, Eva, primary, Büttner, Reinhard, primary, and Hartmann, Wolfgang, primary

Published
2023
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46. Data from The Prosurvival IKK-Related Kinase IKKϵ Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine

Author

Göktuna, Serkan Ismail, primary, Shostak, Kateryna, primary, Chau, Tieu-Lan, primary, Heukamp, Lukas C., primary, Hennuy, Benoit, primary, Duong, Hong-Quan, primary, Ladang, Aurélie, primary, Close, Pierre, primary, Klevernic, Iva, primary, Olivier, Fabrice, primary, Florin, Alexandra, primary, Ehx, Grégory, primary, Baron, Frédéric, primary, Vandereyken, Maud, primary, Rahmouni, Souad, primary, Vereecke, Lars, primary, van Loo, Geert, primary, Büttner, Reinhard, primary, Greten, Florian R., primary, and Chariot, Alain, primary

Published
2023
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48. Supplementary Figure Legend from SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells

Author

Michels, Sebastian, primary, Trautmann, Marcel, primary, Sievers, Elisabeth, primary, Kindler, Dagmar, primary, Huss, Sebastian, primary, Renner, Marcus, primary, Friedrichs, Nicolaus, primary, Kirfel, Jutta, primary, Steiner, Susanne, primary, Endl, Elmar, primary, Wurst, Peter, primary, Heukamp, Lukas, primary, Penzel, Roland, primary, Larsson, Olle, primary, Kawai, Akira, primary, Tanaka, Shinya, primary, Sonobe, Hiroshi, primary, Schirmacher, Peter, primary, Mechtersheimer, Gunhild, primary, Wardelmann, Eva, primary, Büttner, Reinhard, primary, and Hartmann, Wolfgang, primary

Published
2023
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50. Supplementary Tables 1 - 2 from SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells

Author

Michels, Sebastian, primary, Trautmann, Marcel, primary, Sievers, Elisabeth, primary, Kindler, Dagmar, primary, Huss, Sebastian, primary, Renner, Marcus, primary, Friedrichs, Nicolaus, primary, Kirfel, Jutta, primary, Steiner, Susanne, primary, Endl, Elmar, primary, Wurst, Peter, primary, Heukamp, Lukas, primary, Penzel, Roland, primary, Larsson, Olle, primary, Kawai, Akira, primary, Tanaka, Shinya, primary, Sonobe, Hiroshi, primary, Schirmacher, Peter, primary, Mechtersheimer, Gunhild, primary, Wardelmann, Eva, primary, Büttner, Reinhard, primary, and Hartmann, Wolfgang, primary

Published
2023
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