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621 results on '"Hetzel M"'

1. Preparation of mesoscopic atomic ensembles with single-particle resolution

Author

Hüper, A., Pür, C., Hetzel, M., Geng, J., Peise, J., Kruse, I., Kristensen, M., Ertmer, W., Arlt, J., and Klempt, C.

Subjects
Quantum Physics, Condensed Matter - Quantum Gases, Physics - Atomic Physics
Abstract

The analysis of entangled atomic ensembles and their application for interferometry beyond the standard quantum limit requires an accurate determination of the number of atoms. We present an accurate fluorescence detection technique for atoms that is fully integrated into an experimental apparatus for the production of many-particle entangled quantum states. Single-particle resolving fluorescence measurements for $1$ up to $30$ atoms are presented. According to our noise analysis, we extrapolate that the single-atom resolution extends to a limiting atom number of $390(20)$ atoms. We utilize the accurate atom number detection for a number stabilization of the laser-cooled atomic ensemble. For a target ensemble size of $7$ atoms prepared on demand, we achieve a $92(2)\,\%$ preparation fidelity and reach number fluctuations $18(1)\,\mathrm{dB}$ below the shot noise level using real-time feedback on the magneto-optical trap., Comment: 10 pages, 4 figures

Published
2019

2. How technological frames transform : the case of the global microgrid industry

Author

Hetzel, M.

Subjects
T Technology (General)
Abstract

This thesis applies three distinct technology-centred perspectives to explore the mechanisms through which an emergent, complex technology gains acceptance. I develop innovative models to improve our understanding of the processes by which technologies are adopted and institutionalised. This work was motivated by studies that have addressed criticisms to give technology a more central role within the management and organisation science literature and by looking at solutions to the far-reaching consequences of the current energy transition and related problems. The main setting is the global energy sector with a focus on microgrids, which are self-sufficient energy systems. Considering the significance of microgrids for the transformation towards a more sustainable energy sector, they have only received limited attention outside the technical literature. Paper 1 is an in-depth industry study of the emergence of the energy sector and microgrid technologies. It provides the reader with a deeper understanding of microgrid technologies and the markets through which they are bought, sold, and eventually spread. The study integrates the global microgrid industry into the historical context of energy transitions and decentralization and elaborates the technology's relevance in these processes and what tensions exist that might hinder its adoption. The paper's main contribution is to provide a novel perspective on the energy sector and microgrids reflecting recent developments by considering a wide spectrum of data sources. The paper analyses over 245 cited sources reaching from academic journal papers to practitioner industry proceedings, specialist industry publications, news websites and forums, consulting and research reports, as well as company white papers and websites. The engagement with industry experts revealed that non-standardization of microgrid technologies is a key concern. This led to the second study to explore how the interpretation of a technology's capabilities, focusing on standardizability, changes over time and affects the technology's trajectory. Paper 2 extends prior research by introducing the concept of complexity differentials, which describe the difference between the complexity of a technology and the complexity of the technology's environment, to technological frames. Technological frames were introduced as a concept for understanding how organisational stakeholders evaluate and experience technologies. I argue that previous research has not sufficiently examined the role of complexity differentials in determining the usefulness of technological frames. The two-year study of the emerging microgrid industry examines technological frames dynamics by considering the role of complexity. It emphasises the importance of how novel technologies are framed as large deviations between the framing and technology destabilise the frame and thus reduce the understanding and adoption of a technology. I find that technological frames that extensively deviate in complexity from the technology they describe become instable over time, ultimately leading to their transformation or overall replacement. This perspective adds to the literature that examines the limitations of frames such as encouraging overconfidence in a technology, inhibit learning and problem-solving processes, or reinforcing unreflective reliance on established assumptions. The processes studied in paper 2 unveiled that our understanding of how technologies become accepted often does not include the materiality of the technology as a central factor. This led to the third paper, that aims to give the technology itself a more central role in the proposed technology institutionalisation process model. Paper 3 is a conceptual study in form of a multi-level model of technology institutionalisation incorporating micro, meso, and macro-lenses to better explain how novel technologies become widely accepted and taken-for-granted. The paper presents a conceptual model to guide future studies of the technology institutionalisation process. In arguing for a more technology-centred approach to investigate the institutionalisation process of novel technologies, the study conceptualises technology as an independent institution. It addresses the lack of technology-focused studies within institutional theory, as well as the call for multi-level models to explain the technology institutionalisation process. The proposed multi-level model of technology institutionalisation emphasises that micro and macro-level of analysis should be regarded as complementary to each other and that both technological and organisational field-level mechanisms act as moderating forces within the technology institutionalisation process.

Published
2021

5. SEIS: Insight’s Seismic Experiment for Internal Structure of Mars

Author

Lognonné, P., Banerdt, W. B., Giardini, D., Pike, W. T., Christensen, U., Laudet, P., de Raucourt, S., Zweifel, P., Calcutt, S., Bierwirth, M., Hurst, K. J., Ijpelaan, F., Umland, J. W., Llorca-Cejudo, R., Larson, S. A., Garcia, R. F., Kedar, S., Knapmeyer-Endrun, B., Mimoun, D., Mocquet, A., Panning, M. P., Weber, R. C., Sylvestre-Baron, A., Pont, G., Verdier, N., Kerjean, L., Facto, L. J., Gharakanian, V., Feldman, J. E., Hoffman, T. L., Klein, D. B., Klein, K., Onufer, N. P., Paredes-Garcia, J., Petkov, M. P., Willis, J. R., Smrekar, S. E., Drilleau, M., Gabsi, T., Nebut, T., Robert, O., Tillier, S., Moreau, C., Parise, M., Aveni, G., Ben Charef, S., Bennour, Y., Camus, T., Dandonneau, P. A., Desfoux, C., Lecomte, B., Pot, O., Revuz, P., Mance, D., tenPierick, J., Bowles, N. E., Charalambous, C., Delahunty, A. K., Hurley, J., Irshad, R., Liu, Huafeng, Mukherjee, A. G., Standley, I. M., Stott, A. E., Temple, J., Warren, T., Eberhardt, M., Kramer, A., Kühne, W., Miettinen, E.-P., Monecke, M., Aicardi, C., André, M., Baroukh, J., Borrien, A., Bouisset, A., Boutte, P., Brethomé, K., Brysbaert, C., Carlier, T., Deleuze, M., Desmarres, J. M., Dilhan, D., Doucet, C., Faye, D., Faye-Refalo, N., Gonzalez, R., Imbert, C., Larigauderie, C., Locatelli, E., Luno, L., Meyer, J.-R., Mialhe, F., Mouret, J. M., Nonon, M., Pahn, Y., Paillet, A., Pasquier, P., Perez, G., Perez, R., Perrin, L., Pouilloux, B., Rosak, A., Savin de Larclause, I., Sicre, J., Sodki, M., Toulemont, N., Vella, B., Yana, C., Alibay, F., Avalos, O. M., Balzer, M. A., Bhandari, P., Blanco, E., Bone, B. D., Bousman, J. C., Bruneau, P., Calef, F. J., Calvet, R. J., D’Agostino, S. A., de los Santos, G., Deen, R. G., Denise, R. W., Ervin, J., Ferraro, N. W., Gengl, H. E., Grinblat, F., Hernandez, D., Hetzel, M., Johnson, M. E., Khachikyan, L., Lin, J. Y., Madzunkov, S. M., Marshall, S. L., Mikellides, I. G., Miller, E. A., Raff, W., Singer, J. E., Sunday, C. M., Villalvazo, J. F., Wallace, M. C., Banfield, D., Rodriguez-Manfredi, J. A., Russell, C. T., Trebi-Ollennu, A., Maki, J. N., Beucler, E., Böse, M., Bonjour, C., Berenguer, J. L., Ceylan, S., Clinton, J., Conejero, V., Daubar, I., Dehant, V., Delage, P., Euchner, F., Estève, I., Fayon, L., Ferraioli, L., Johnson, C. L., Gagnepain-Beyneix, J., Golombek, M., Khan, A., Kawamura, T., Kenda, B., Labrot, P., Murdoch, N., Pardo, C., Perrin, C., Pou, L., Sauron, A., Savoie, D., Stähler, S., Stutzmann, E., Teanby, N. A., Tromp, J., van Driel, M., Wieczorek, M., Widmer-Schnidrig, R., and Wookey, J.

Published
2019
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6. Multiplexed ddPCR-amplicon sequencing reveals isolated Plasmodium falciparum populations amenable to local elimination in Zanzibar, Tanzania

Author

Holzschuh, A., Lerch, A., Gerlovina, I., Fakih, B. S., Al-Mafazy, A. H., Reaves, E. J., Ali, A., Abbas, F., Ali, M. H., Ali, M. A., Hetzel, M. W., Yukich, J., and Koepfli, C.

Abstract

Zanzibar has made significant progress toward malaria elimination, but recent stagnation requires novel approaches. We developed a highly multiplexed droplet digital PCR (ddPCR)-based amplicon sequencing method targeting 35 microhaplotypes and drug-resistance loci, and successfully sequenced 290 samples from five districts covering both main islands. Here, we elucidate fine-scale Plasmodium falciparum population structure and infer relatedness and connectivity of infections using an identity-by-descent (IBD) approach. Despite high genetic diversity, we observe pronounced fine-scale spatial and temporal parasite genetic structure. Clusters of near-clonal infections on Pemba indicate persistent local transmission with limited parasite importation, presenting an opportunity for local elimination efforts. Furthermore, we observe an admixed parasite population on Unguja and detect a substantial fraction (2.9%) of significantly related infection pairs between Zanzibar and the mainland, suggesting recent importation. Our study provides a high-resolution view of parasite genetic structure across the Zanzibar archipelago and provides actionable insights for prioritizing malaria elimination efforts.

Published
2023

9. Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens

Author

Naung, MT, Martin, E, Munro, J, Mehra, S, Guy, AJ, Laman, M, Harrison, GLA, Tavul, L, Hetzel, M, Kwiatkowski, D, Mueller, I, Bahlo, M, Barry, Alyssa, Naung, MT, Martin, E, Munro, J, Mehra, S, Guy, AJ, Laman, M, Harrison, GLA, Tavul, L, Hetzel, M, Kwiatkowski, D, Mueller, I, Bahlo, M, and Barry, Alyssa

Abstract

Investigation of the diversity of malaria parasite antigens can help prioritize and validate them as vaccine candidates and identify the most common variants for inclusion in vaccine formulations. Studies of vaccine candidates of the most virulent human malaria parasite, Plasmodium falciparum, have focused on a handful of well-known antigens, while several others have never been studied. Here we examine the global diversity and population structure of leading vaccine candidate antigens of P. falciparum using the MalariaGEN Pf3K (version 5.1) resource, comprising more than 2600 genomes from 15 malaria endemic countries. A stringent variant calling pipeline was used to extract high quality antigen gene 'haplotypes' from the global dataset and a new R-package named VaxPack was used to streamline population genetic analyses. In addition, a newly developed algorithm that enables spatial averaging of selection pressure on 3D protein structures was applied to the dataset. We analysed the genes encoding 23 leading and novel candidate malaria vaccine antigens including csp, trap, eba175, ama1, rh5, and CelTOS. Our analysis shows that current malaria vaccine formulations are based on rare haplotypes and thus may have limited efficacy against natural parasite populations. High levels of diversity with evidence of balancing selection was detected for most of the erythrocytic and pre-erythrocytic antigens. Measures of natural selection were then mapped to 3D protein structures to predict targets of functional antibodies. For some antigens, geographical variation in the intensity and distribution of these signals on the 3D structure suggests adaptation to different human host or mosquito vector populations. This study provides an essential framework for the diversity of P. falciparum antigens to be considered in the design of the next generation of malaria vaccines.

Published
2022

10. Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens

Author

Wallqvist, A, Naung, MT, Martin, E, Munro, J, Mehra, S, Guy, AJ, Laman, M, Harrison, GLA, Tavul, L, Hetzel, M, Kwiatkowski, D, Mueller, I, Bahlo, M, Barry, AE, Wallqvist, A, Naung, MT, Martin, E, Munro, J, Mehra, S, Guy, AJ, Laman, M, Harrison, GLA, Tavul, L, Hetzel, M, Kwiatkowski, D, Mueller, I, Bahlo, M, and Barry, AE

Abstract

Investigation of the diversity of malaria parasite antigens can help prioritize and validate them as vaccine candidates and identify the most common variants for inclusion in vaccine formulations. Studies of vaccine candidates of the most virulent human malaria parasite, Plasmodium falciparum, have focused on a handful of well-known antigens, while several others have never been studied. Here we examine the global diversity and population structure of leading vaccine candidate antigens of P. falciparum using the MalariaGEN Pf3K (version 5.1) resource, comprising more than 2600 genomes from 15 malaria endemic countries. A stringent variant calling pipeline was used to extract high quality antigen gene 'haplotypes' from the global dataset and a new R-package named VaxPack was used to streamline population genetic analyses. In addition, a newly developed algorithm that enables spatial averaging of selection pressure on 3D protein structures was applied to the dataset. We analysed the genes encoding 23 leading and novel candidate malaria vaccine antigens including csp, trap, eba175, ama1, rh5, and CelTOS. Our analysis shows that current malaria vaccine formulations are based on rare haplotypes and thus may have limited efficacy against natural parasite populations. High levels of diversity with evidence of balancing selection was detected for most of the erythrocytic and pre-erythrocytic antigens. Measures of natural selection were then mapped to 3D protein structures to predict targets of functional antibodies. For some antigens, geographical variation in the intensity and distribution of these signals on the 3D structure suggests adaptation to different human host or mosquito vector populations. This study provides an essential framework for the diversity of P. falciparum antigens to be considered in the design of the next generation of malaria vaccines.

Published
2022

11. Positionspapier zu Ursachen und Diagnostik der Beatmungsabhängigkeit sowie zu praktischer Durchführung und Abrechnung des Weaning-Prozesses

Author

Hetzel M, Michael Westhoff, Dominic Dellweg, J. Geiseler, T. Voshaar, and Michael Pfeifer

Subjects
Pulmonary and Respiratory Medicine, Statement (computer science), business.industry, medicine.disease, language.human_language, law.invention, German, law, Ventilation (architecture), language, Medicine, Weaning, Medical emergency, business, Dependency (project management)
Published
2019
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13. Science Goals and Mission Architecture of the Europa Lander Mission Concept

Author

Hand, K. P., primary, Phillips, C. B., additional, Murray, A., additional, Garvin, J. B., additional, Maize, E. H., additional, Gibbs, R. G., additional, Reeves, G., additional, Martin, A. M. San, additional, Tan-Wang, G. H., additional, Krajewski, J., additional, Hurst, K., additional, Crum, R., additional, Kennedy, B. A., additional, McElrath, T. P., additional, Gallon, J. C., additional, Sabahi, D., additional, Thurman, S. W., additional, Goldstein, B., additional, Estabrook, P., additional, Lee, S. W., additional, Dooley, J. A., additional, Brinckerhoff, W. B., additional, Edgett, K. S., additional, German, C. R., additional, Hoehler, T. M., additional, Hörst, S. M., additional, Lunine, J. I., additional, Paranicas, C., additional, Nealson, K., additional, Smith, D. E., additional, Templeton, A. S., additional, Russell, M. J., additional, Schmidt, B., additional, Christner, B., additional, Ehlmann, B., additional, Hayes, A., additional, Rhoden, A., additional, Willis, P., additional, Yingst, R. A., additional, Craft, K., additional, Cameron, M. E., additional, Nordheim, T., additional, Pitesky, J., additional, Scully, J., additional, Hofgartner, J., additional, Sell, S. W., additional, Barltrop, K. J., additional, Izraelevitz, J., additional, Brandon, E. J., additional, Seong, J., additional, Jones, J.-P., additional, Pasalic, J., additional, Billings, K. J., additional, Ruiz, J. P., additional, Bugga, R. V., additional, Graham, D., additional, Arenas, L. A., additional, Takeyama, D., additional, Drummond, M., additional, Aghazarian, H., additional, Andersen, A. J., additional, Andersen, K. B., additional, Anderson, E. W., additional, Babuscia, A., additional, Backes, P. G., additional, Bailey, E. S., additional, Balentine, D., additional, Ballard, C. G., additional, Berisford, D. F., additional, Bhandari, P., additional, Blackwood, K., additional, Bolotin, G. S., additional, Bovre, E. A., additional, Bowkett, J., additional, Boykins, K. T., additional, Bramble, M. S., additional, Brice, T. M., additional, Briggs, P., additional, Brinkman, A. P., additional, Brooks, S. M., additional, Buffington, B. B., additional, Burns, B., additional, Cable, M. L., additional, Campagnola, S., additional, Cangahuala, L. A., additional, Carr, G. A, additional, Casani, J. R., additional, Chahat, N. E., additional, Chamberlain-Simon, B. K., additional, Cheng, Y., additional, Chien, S. A., additional, Cook, B. T., additional, Cooper, M., additional, DiNicola, M., additional, Clement, B., additional, Dean, Z., additional, Cullimore, E. A., additional, Curtis, A. G., additional, Croix, J-P. de la, additional, Pasquale, P. Di, additional, Dodd, E. M., additional, Dubord, L. A., additional, Edlund, J. A., additional, Ellyin, R., additional, Emanuel, B., additional, Foster, J. T., additional, Ganino, A. J., additional, Garner, G. J., additional, Gibson, M. T., additional, Gildner, M., additional, Glazebrook, K. J., additional, Greco, M. E., additional, Green, W. M., additional, Hatch, S. J., additional, Hetzel, M. M., additional, Hoey, W. A., additional, Hofmann, A. E., additional, Ionasescu, R., additional, Jain, A., additional, Jasper, J. D., additional, Johannesen, J. R., additional, Johnson, G. K., additional, Jun, I., additional, Katake, A. B., additional, Kim-Castet, S. Y., additional, Kim, D. I., additional, Kim, W., additional, Klonicki, E. F., additional, Kobeissi, B., additional, Kobie, B. D., additional, Kochocki, J., additional, Kokorowski, M., additional, Kosberg, J. A., additional, Kriechbaum, K., additional, Kulkarni, T. P., additional, Lam, R. L., additional, Landau, D. F., additional, Lattimore, M. A., additional, Laubach, S. L., additional, Lawler, C. R., additional, Lim, G., additional, Lin, J. Y, additional, Litwin, T. E., additional, Lo, M. W., additional, Logan, C. A., additional, Maghasoudi, E., additional, Mandrake, L., additional, Marchetti, Y., additional, Marteau, E., additional, Maxwell, K. A., additional, Namee, J. B. Mc, additional, Mcintyre, O., additional, Meacham, M., additional, Melko, J. P., additional, Mueller, J., additional, Muliere, D. A., additional, Mysore, A., additional, Nash, J., additional, Ono, H., additional, Parker, J. M., additional, Perkins, R. C., additional, Petropoulos, A. E, additional, Gaut, A., additional, Gomez, M. Y. Piette, additional, Casillas, R. P., additional, Preudhomme, M., additional, Pyrzak, G., additional, Rapinchuk, J., additional, Ratliff, J. M., additional, Ray, T. L., additional, Roberts, E. T., additional, Roffo, K., additional, Roth, D. C., additional, Russino, J. A., additional, Schmidt, T. M., additional, Schoppers, M. J., additional, Senent, J. S., additional, Serricchio, F., additional, Sheldon, D. J., additional, Shiraishi, L. R., additional, Shirvanian, J., additional, Siegel, K. J., additional, Singh, G., additional, Sirota, A. R., additional, Skulsky, E. D., additional, Stehly, J. S., additional, Strange, N. J., additional, Stevens, S. U., additional, Sunada, E. T., additional, Tepsuporn, S. P., additional, Tosi, L. P. C., additional, Trawny, N., additional, Uchenik, I., additional, Verma, V., additional, Volpe, R. A., additional, Wagner, C. T., additional, Wang, D., additional, Willson, R. G., additional, Wolff, J. L., additional, Wong, A. T., additional, Zimmer, A. K., additional, Sukhatme, K. G., additional, Bago, K. A., additional, Chen, Y., additional, Deardorff, A. M., additional, Kuch, R. S., additional, Lim, C., additional, Syvertson, M. L., additional, Arakaki, G. A., additional, Avila, A., additional, DeBruin, K. J., additional, Frick, A., additional, Harris, J. R., additional, Heverly, M. C., additional, Kawata, J. M., additional, Kim, S.-K., additional, Kipp, D. M., additional, Murphy, J., additional, Smith, M. W., additional, Spaulding, M. D., additional, Thakker, R., additional, Warner, N. Z., additional, Yahnker, C. R., additional, Young, M. E., additional, Magner, T., additional, Adams, D., additional, Bedini, P., additional, Mehr, L., additional, Sheldon, C., additional, Vernon, S., additional, Bailey, V., additional, Briere, M., additional, Butler, M., additional, Davis, A., additional, Ensor, S., additional, Gannon, M., additional, Haapala-Chalk, A., additional, Hartka, T., additional, Holdridge, M., additional, Hong, A., additional, Hunt, J., additional, Iskow, J., additional, Kahler, F., additional, Murray, K., additional, Napolillo, D., additional, Norkus, M., additional, Pfisterer, R., additional, Porter, J., additional, Roth, D., additional, Schwartz, P., additional, Wolfarth, L., additional, Cardiff, E. H., additional, Grob, E. W., additional, Adam, J. R., additional, Betts, E., additional, Norwood, J., additional, Heller, M. M., additional, Voskuilen, T., additional, Sakievich, P., additional, Gray, L., additional, Hansen, D. J., additional, Irick, K. W., additional, Hewson, J. C., additional, Lamb, J., additional, Stacy, S. C., additional, Brotherton, C. M., additional, Tappan, A. S, additional, Benally, D., additional, Thigpen, H., additional, Ortiz, E., additional, Sandoval, D., additional, Ison, A. M., additional, Warren, M., additional, Stromberg, P. G., additional, Thelen, P. M., additional, Blasy, B., additional, Nandy, P., additional, Haddad, A. W., additional, Trujillo, L. B., additional, Wiseley, T. H., additional, Bell, S. A., additional, Teske, N. P., additional, Post, C., additional, Torres-Castro, L., additional, Grosso, C., additional, and Wasiolek, M., additional

Published
2022
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29. Leserbrief zu M. Bitzer. Hohe Luftverschmutzung begünstigt das Auftreten von Lungenemphysemen. Pneumologie 2020; 74: 7–8 und F. Klein. Stickoxide schädigen Schulkinderlungen unabhängig von Vorerkrankungen. Pneumologie 2020: 74: 8–9

Author

Köhler, D., additional, Hetzel, M., additional, Klingner, M., additional, Koch, T., additional, Ewig, S., additional, Becher, G., additional, Lindemann, H., additional, Voshaar, T., additional, and Costabel, U., additional

Published
2020
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40. Albinismus und Lungenfibrose

Author

Ewers, T., primary, Schwaderer, P., additional, Soerensen, A., additional, Zenner, M., additional, Hetzel, K., additional, Würth, H., additional, and Hetzel, M., additional

Published
2019
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